Program (preliminary):

Wenesday Thursday Friday

7:30-8:20 - Registration

8:20-8:30 - Opening

8:30-10:30 – Actin I 8:30-10:30 – Tissues / 8:30-10:30 – Actin II Koenderink Cancer Bassereau Lenz Friedl Steinem Janshoff Charras Blanchoin Bernheim Betz Merkel Thirumalai

10:30-11:00 Coffee 10:30-11:00 Coffee 10:30-11:00 Coffee

11:00-13:00 – Immune Cells 11:00-12:30 – Cell State 11:00-13:00 Sengupta Huang Theodoly Emonet 2 x 8 Contributed talks Lenon-Dumenil – Membrane Paszek proteins Hummer

13:00-14:00 – Lunch Buffet 12:30-13:30 - Lunch Buffet 13:00-14:00 – Lunch Buffet & Poster & Poster & Poster

14:00-15:00 13:30-15:00 14:00-17:00 - Microtubules Svitkina 2 x 4 Contributed talks 2 x 6 Contributed talks Bershadsky Janke Tolic

15:00-15:20 – Coffee 15:00-15:20 - Coffee 17:00 - FIN

15:20-16:20 15:20-16:20

2 x 4 Contributed talks 2 x 4 Contributed talks

16:30-17:30 – Cell nucleus 16:30-17:30 – Adhesion Hawkins Smith Discher Gaub

17:30-19:00 17:30-19:00

Posters & Snacks Posters & Snacks

19:00 - … Social dinner 19:00 - … Social dinner (Aula) (Tent) List of invited speakers (with title)

Patricia Bassereau (Institut Curie, Paris, France) Linkers at the membrane-cortical actin interface: only linkers? Anne Bernheim (Ben Gurion University, Israel) Spontaneous shape transitions of active contractile sheets Alexander Bershadsky (National University of Singapore, Singapore) Crosstalk between myosin IIA filaments, integrin-mediated cell-matrix adhesions, and microtubules Timo Betz (University of Münster, ) Walk my way: Collective migration in development and cancer Laurent Blanchoin, (Biosciences & Biotech. Institute, Grenoble, France) Reconstitution of the dynamic steady state of actin networks. Guillaume Charras (University College London, UK) Dissecting the intercellular forces shaping tissues Dennis Discher (University of Pennsylvania, Philadelphia, USA) Curvature induced rupture of nuclei Thierry Emonet (, New Haven CT, USA) Individual variability and spatiotemporal organization in motile populations Peter Friedl (Radboud University, Nijmegen, Netherlands) Jamming transitions of cancer cells during tissue invasion Hermann Gaub (Ludwig Maximilian University of Munich, Germany) Molecular Mechanisms of Extreme Mechanostability in Microbial Adhesion Rhoda Hawkins (University of Sheffield, UK) Force exertion on the cell nucleus Sui Huang (Institute for Systems , Seattle, USA) Dynamics of cell state transitions – theory & single-cell transcriptomics Gerhard Hummer (MPI Biophysics, , Germany) t.b.a. Carsten Janke (Institut Curie, Orsay, France) The tubulin code – a mechanism to control microtubule properties Andreas Janshoff (University of Göttingen, Germany) Viscoelastic properties of cells and cellular cortices Gijsje Koenderink (Delft University of Technology, Netherlands) From mechanical resilience to active material properties in biopolymer networks Ana-Maria Lennon-Duménil (Institut Curie, Paris, France) t.b.a. Martin Lenz (Paris-Sud University, France) Elasticity from entanglements in branched actin Rudolf Merkel (Forschungszentrum Jülich, Jülich, Germany) Cyclic Stretch is a Potent Cue for Animal Cells Pawel Paszek (University of Manchester, UK) Dynamics and heterogeneity of inflammatory signaling in cells and tissues Kheya Sengupta (Aix-Marseille University, France) Morphodynamics and mechanosensitivity of spreading T cells Ana-Sunčana Smith (University of Erlangen–Nürnberg, Germany) Physical effects catalyzing cell adhesion: from mimetic systems to cell adhesion Claudia Steinem (University of Göttingen, Germany) The architecture and mechanics of ezrin-linked minimal actin cortices Tatyana Svitkina (University of Pennsylvania, Philadelphia, USA) How microtubules induce local membrane protrusion Olivier Théodoly (INSERM Marseille, France) Directed migration of lymphocytes by integrins Dave Thirumalai (University of Texas, Austin, USA) Cell growth rate dictates the onset of glass to fluid-like transition and long time super-diffusion in an evolving cell colony Iva Tolić (Ruđer Bošković Institute, Zagreb , Croatia) Torques and forces in the mitotic spindle

List of contributed talks (with title)

Mohammad Abu Hamed (Technion - Israel Institute of Technology ) A simple model of keratocyte interface dynamics Dalia Alansary ( University, Homburg) Biochemical and electrophysiological approaches for studying the stoichiometry of ORAI channels Fern Armistead (University of Leed) Mechanical phenotyping of single cells using shear and inertial microfluidics Christian Bächer () Blood platelet formation - a biological Rayleigh-Plateau instability Luca Barberi (LPTMS, CNRS, Université Paris-Sud, Université Paris-Saclay Orsay) ESCRT-III helical polymers deform membranes into helical tubes Tobias Büscher (Forschungszentrum Jülich, Institute of Complex Systems II) Tissue Competition: Coexistence and Tumor Heterogeneity Clément Campillo (Université d'Evry) Morphology and mechanics of membrane nanotubes interacting with reconstituted actin networks Chii Chan (EMBL Heidelberg) A bottom-up approach to study the interplay between signaling and mechanics in early mammalian embryogenesis Saptarshi Chatterjee (Indian Association for the Cultivation of Science, Kolkata) Microtubule search-and-capture mechanism orchestrates MTOC clustering and nuclear division via proper spindle positioning in yeast Indra Navina Dahmke (INM-Leibniz Institute for New Materials , Saarbrücken) Association of signaling active ErbB2 homodimers with actin-rich membrane structures of cancer cells revealed by liquid phase electron microscopy Christian Dietz (Institute of Materials Science, Technische Universität Darmstadt) Nanomechanical sub-surface mapping of living biological cells by force microscopy Oded Farago (Ben Gurion University, Beer Sheva) Interplay between membrane elasticity and active cytoskeleton forces regulates the aggregation dynamics of the immunological synapse Daniel Flormann (INM-Leibniz Institute for New Materials , Saarbrücken) Structural analysis of the actin cortex and its correlation to cell mechanics in adhered and suspended states Joel Forster (University College London) Relating Surface Structure to Function in Cell Membrane Penetrating Nanoparticles Thierry Fredrich (, Saarbrücken) Fine-grained simulation of the microenvironment of vascularized tumors Bob Fregin (University of ) Dynamic real-time deformability cytometry: High-throughput single cell rheology in complex samples Sadegh Ghorbani (iNANO/CellPAT Center, ) Restricting desmosomal assembly in interfollicular stem cells (IFSCs) via desmosomal protein nanopatterns Pau Guillamat (Université de Genève) Integer topological defects steer cell flows during tissue morphogenesis Anne Hafner (University College London) Physical modelling of ESCRT-III mediated cell division in archaea Hendrik Hähl (Saarland University, Saarbrücken) Hydrophobins: Model proteins and building blocks for lipid-free membranes and vesicles Mitchell Han (INM-Leibniz Institute for New Materials, Saarbrücken) Optoregulated force application to individual cellular receptors using molecular motors Stephanie Hoehn (University of Cambridge) Morphogenesis is stressful – Elasticity and Mechanics of Folding Cell Sheets Miloš Ivanović (Saarland University. Saarbrücken) Interpretation of SAXS data using MD simulations: Detergent micelles and ion cloud of charged proteins Satoru Kidoaki (IMCE, Kyushu University Fukuoka) Exercising mesenchymal stem cells through nomadic culture on heterogeneous field of matrix e lasticity Yesaswini Komaragiri (Universität Greifswald) Role of oxidative stress on the cell mechanical properties of suspended and adherent cells Julia Kraxner (Universität Göttingen) Recovery Behavior of Single Vimentin Filaments Aldo Leal-Egana (Universität Erlangen-Nürnberg) Confining cancer cells in 3D tumor-like microcapsules: A new strategy to induce tumor heterogeneity in vitro, and to enhance extravasation capabilities in vivo. Ayelet Lesman (School of Mechanical Engineering, Tel-Aviv University) Mechanical interactionbetween cells in fibrous environments Charlotta Lorenz (University of Göttingen) Lateral Subunit Coupling Determines Intermediate Filament Mechanics Gabriele Lubatti (Helmholtz Zentrum Munich) Cell competition in mouse embryo Karol Makuch (Institute of Physical , Polish Academy of Sciences, Warsaw) Stokes' in complex liquids and inside cell cytoplasm Matthieu Mangeat (Saarland University, Saarbrücken) The narrow escape problem in a circular domain with radial piecewise constant diffusivity Daniel Alejandro Matoz-Fernandez (School of Life Sciences, University of Dundee) Growth, form and active mechanics in biology Cornelia Monzel (Universität Düsseldorf) Subcellular Transfer of Nanoparticles and Targeting of Organelles Javad Najafi (Saarland University, Saarbrücken) Flagellar number governs bacterial spreading and transport efficiency Daniel Pearce (University of Geneva) Geometry and mechanics of growing bacterial suspensions Audrey Prunet (Institut Lumière Matière, Lyon) Soft cell confiner development to decipher the impact of mechanical stimuli on cancer cells Jakob Rosenbauer (Forschungszentrum Jülich) Multiscale Modeling of Tumor Development Naruemon Rueangkham (The University of Sheffield) Intracellular transport by molecular motors: the effect of number of binding sites Shrikrishnan Sankaran (INM - Leibiniz Institute for New Materials, Saarbrücken) Bacterial confinement in hydrogels to develop living therapeutic materials Anna Schepers (University ofcGöttingen) Tuning the mechanics of single intermediate filaments Reza Shaebani (Saarland University, Saarbrücken) Dynamics, correlations, and search optimization in active processes with distinct motility states Ewa Sitarska (EMBL Heidelberg) Towards understanding the role of BAR domain proteins in membrane tension sensing Kristina Sliogeryte (Queen Mary University of London) Cell mechanical properties in keratinocytes are regulated by cell-cell adhesions Christian Spengler (Saarland University, Saabrücken) Single-Cell Force Spectroscopy to Study Bacterial Adhesion: Fundamental Mechanisms and Effect of Substrate Nano-Topography Baeckkyoung Sung (KIST , Saarbrücken) Dynamics of immune cell morphology and motility on a topographical surface with controlled elasticity Hans van Oosterwyck (KU Leuven) Sprouting angiogenesis relies on tip cell pulling forces Diego Vargas (KU Leuven) Effect of substrate stiffness on balance of active cell-cell and cell-ECM forces studied through a computational model of a deformable cell pair Gerrit Vliegenthart (Institute for Advanced Simulation, Forschungszentrum Jülich) Filamentous Active Matter: Band Formation, Bending, Buckling, and Defects Andreas Weber (University of Natural Resources and Life Sciences Vienna) Does estrogen receptor drug binding influence breast cancer cell viscoelasticity? Jiawei Yan (Harvard University, Cambridge) Kinetic uncertainty relations in stochastic control Guanming Zhang (University of Oxford) Collective behaviour of epithelial cells under different coordinated dynamics of cell polarisation