G C A T T A C G G C A T genes Review Comprehensive History of CSP Genes: Evolution, Phylogenetic Distribution and Functions 1, 1, 2 3 3 Guoxia Liu y, Ning Xuan y, Balaji Rajashekar , Philippe Arnaud , Bernard Offmann and Jean-François Picimbon 1,4,* 1 Biotechnology Research Center, Shandong Academy of Agricultural Sciences, Jinan 250100, China;
[email protected] (G.L.);
[email protected] (N.X.) 2 Institute of Computer Science, University of Tartu, Tartu 50090, Estonia;
[email protected] 3 Protein Engineering and Functionality Unit, University of Nantes, 44322 Nantes, France;
[email protected] (P.A.); bernard.off
[email protected] (B.O.) 4 School of Bioengineering, Qilu University of Technology, Jinan 250353, China * Correspondence:
[email protected]; Tel.: +86-531-89631190 Same contribution: G.L. (Bemisia), Ning Xuan (Bombyx). y Received: 10 February 2020; Accepted: 6 April 2020; Published: 10 April 2020 Abstract: In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction. Here, we focus on direct functional consequences on protein function depending on duplication, expression and RNA editing. The result of our analysis is important for understanding the significance of RNA-editing on functionality of CSP genes, particularly in the brain tissue. Keywords: tandem duplication; RNA mutation; adaptive process; lipid transport; xenobiotic resistance; neuroplasticity This report reviews duplication, expression, evolution and RNA editing of CSP genes for neofunctionalization in insecticide resistance and neuroplasticity, with a particular special interest in functional properties of insect chemosensory proteins (CSPs).