Table S8. positively selected (PSGs) identified in glyptosternoid and yellowhead catfish lineages.

Lineage ID Gene name Gene description P-value Corrected P-value

G. maculatum ENSDARG00000000001 slc35a5 solute carrier family 35, member A5 0 0 G. maculatum ENSDARG00000000656 psmb9a proteasome (prosome, macropain) subunit, beta type, 9a 0 0 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde G. maculatum ENSDARG00000016649 akr7a3 0 0 reductase) G. maculatum ENSDARG00000017422 apmap adipocyte plasma membrane associated 0 0 G. maculatum ENSDARG00000003813 srp54 signal recognition particle 54 0 0 G. maculatum ENSDARG00000016173 cct3 chaperonin containing TCP1, subunit 3 (gamma) 0.012102523 0.049848505 G. maculatum ENSDARG00000018049 sf3b2 splicing factor 3b, subunit 2 0 0 G. maculatum ENSDARG00000004581 sel1l sel-1 suppressor of lin-12-like (C. elegans) 0.004079946 0.01759805 G. maculatum ENSDARG00000020344 slc2a8 solute carrier family 2 (facilitated glucose transporter), member 8 0.00E+00 0 G. maculatum ENSDARG00000011885 mitochondrial L19 0 0 G. maculatum ENSDARG00000012640 cideb cell death-inducing DFFA-like effector b 0.00112672 0.005077819 G. maculatum ENSDARG00000003127 zgc:123105 zgc:123105 0 0 G. maculatum ENSDARG00000012929 eif2d eukaryotic 2D 0.001049906 0.004752953 G. maculatum ENSDARG00000012947 SKA2 spindle and associated complex subunit 2 0 0 G. maculatum ENSDARG00000015851 pnn pinin, desmosome associated protein 0 0 G. maculatum ENSDARG00000011418 sigmar1 sigma non-opioid intracellular receptor 1 0.00E+00 0 G. maculatum ENSDARG00000006926 btd biotinidase 0 0 G. maculatum ENSDARG00000012674 rpusd4 RNA pseudouridylate synthase domain containing 4 0.00E+00 0 G. maculatum ENSDARG00000017389 igfbp7 insulin-like growth factor binding protein 7 1.05E-02 0.043622349 G. maculatum ENSDARG00000013478 rrp15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000015221 nsrp1 nuclear speckle splicing regulatory protein 1 0.00E+00 0 G. maculatum ENSDARG00000021439 ncoa4 nuclear receptor coactivator 4 0 0 G. maculatum ENSDARG00000001897 man2b1 mannosidase, alpha, class 2B, member 1 0 0 G. maculatum ENSDARG00000019772 C2 complement component 2 0 0 G. maculatum ENSDARG00000010312 cp ceruloplasmin 0 0 G. maculatum ENSDARG00000010108 bri3bp bri3 binding protein 0 0 G. maculatum ENSDARG00000006005 nudcd3 NudC domain containing 3 0.00E+00 0 G. maculatum ENSDARG00000008395 snupn snurportin 1 0 0 G. maculatum ENSDARG00000021120 ndc1 NDC1 transmembrane nucleoporin 0.008300323 0.035049683 G. maculatum ENSDARG00000013016 POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 0 0 G. maculatum ENSDARG00000019732 mtch2 mitochondrial carrier homolog 2 0.00E+00 0 G. maculatum ENSDARG00000013542 lpgat1 lysophosphatidylglycerol acyltransferase 1 0 0 G. maculatum ENSDARG00000020895 bag1 BCL2-associated athanogene 1 0 0 G. maculatum ENSDARG00000004665 hspa5 heat shock protein 5 0 0 G. maculatum ENSDARG00000012777 nucks1b nuclear casein kinase and cyclin-dependent kinase substrate 1b 0 0 G. maculatum ENSDARG00000003940 mtfr1l mitochondrial fission regulator 1-like 0 0 G. maculatum ENSDARG00000017046 wbp11 WW domain binding protein 11 0.000825745 0.003824303 G. maculatum ENSDARG00000018953 gclm glutamate-cysteine ligase, modifier subunit 0 0 UDP-N-acetyl-alpha-D-galactosamine:polypeptide G. maculatum ENSDARG00000003829 galnt2 0 0 N-acetylgalactosaminyltransferase 2 SWI/SNF related, matrix associated, actin dependent regulator of G. maculatum ENSDARG00000016871 smarce1 1.18E-05 5.71E-05 chromatin, subfamily e, member 1 G. maculatum ENSDARG00000004470 prkcsh protein kinase C substrate 80K-H 0.00E+00 0 G. maculatum ENSDARG00000012066 dcn decorin 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000010021 grpel1 GrpE-like 1, mitochondrial 0.00E+00 0 G. maculatum ENSDARG00000011958 ctnnbl1 catenin, beta like 1 0 0 G. maculatum ENSDARG00000012256 taldo1 transaldolase 1 0.00E+00 0 G. maculatum ENSDARG00000014472 initiation factor 4A, isoform 3 0.00E+00 0 G. maculatum ENSDARG00000009868 dcaf11 ddb1 and cul4 associated factor 11 0 0 G. maculatum ENSDARG00000008292 eukaryotic translation initiation factor 2, subunit 3 gamma 0 0 G. maculatum ENSDARG00000025538 TMEM254 transmembrane protein 254 0 0 G. maculatum ENSDARG00000024818 rilpl2 Rab interacting lysosomal protein-like 2 2.50E-09 1.24E-08 G. maculatum ENSDARG00000025421 tdrd3 tudor domain containing 3 0.002871064 0.012655348 G. maculatum ENSDARG00000025269 pdcd6ip programmed cell death 6 interacting protein 0.00E+00 0 G. maculatum ENSDARG00000026149 slc46a1 solute carrier family 46, member 1 0 0 G. maculatum ENSDARG00000020323 nup153 nucleoporin 153 0.010289313 0.043086496 G. maculatum ENSDARG00000052374 faf2 Fas associated factor family member 2 0 0 G. maculatum ENSDARG00000026892 gpatch11 G patch domain containing 11 5.25E-08 2.57E-07 G. maculatum ENSDARG00000027078 cnppd1 cyclin Pas1/PHO80 domain containing 1 0.00E+00 0 G. maculatum ENSDARG00000022340 ufc1 ubiquitin-fold modifier conjugating enzyme 1 0 0 G. maculatum ENSDARG00000023309 spryd4 SPRY domain containing 4 0 0 G. maculatum ENSDARG00000022232 ppan peter pan homolog (Drosophila) 0.00091226 0.004186396 G. maculatum ENSDARG00000025635 atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 0 0 G. maculatum ENSDARG00000032769 slc38a9 solute carrier family 38, member 9 0.00E+00 0 G. maculatum ENSDARG00000034568 fitm2 fat storage-inducing transmembrane protein 2 0 0 G. maculatum ENSDARG00000028889 ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0 0 G. maculatum ENSDARG00000033586 ryroxd1 pyridine nucleotide-disulphide oxidoreductase domain 1 0 0 G. maculatum ENSDARG00000075380 kri1 KRI1 homolog 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000016132 keap1a kelch-like ECH-associated protein 1a 0 0 G. maculatum ENSDARG00000002830 trmt2a trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae) 0 0 G. maculatum ENSDARG00000023583 coq9 coenzyme Q9 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000030949 srprb signal recognition particle receptor, B subunit 0 0 G. maculatum ENSDARG00000030585 rpl13 ribosomal protein L13 0 0 G. maculatum ENSDARG00000029874 khk ketohexokinase 0 0 G. maculatum ENSDARG00000029724 pqbp1 polyglutamine binding protein 1 0 0 G. maculatum ENSDARG00000015179 mfsd8 major facilitator superfamily domain containing 8 0 0 G. maculatum ENSDARG00000036438 ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1 0 0 G. maculatum ENSDARG00000036784 commd7 COMM domain containing 7 0 0 G. maculatum ENSDARG00000051971 arl6ip4 ADP-ribosylation-like factor 6 interacting protein 4 0.00026288 0.001240347 G. maculatum ENSDARG00000037191 ttr transthyretin (prealbumin, amyloidosis type I) 0 0 G. maculatum ENSDARG00000037423 SMIM19 small integral membrane protein 19 0 0 G. maculatum ENSDARG00000004726 trappc11 trafficking protein particle complex 11 0 0 G. maculatum ENSDARG00000037906 alkbh7 alkB, alkylation repair homolog 7 (E. coli) 0 0 G. maculatum ENSDARG00000037955 pih1d1 PIH1 domain containing 1 3.00E-09 1.48E-08 G. maculatum ENSDARG00000073858 pex26 peroxisomal biogenesis factor 26 0.005419477 0.02317691 G. maculatum ENSDARG00000063446 iba57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000038399 polr3h polymerase (RNA) III (DNA directed) polypeptide H 0.001401418 0.006259667 G. maculatum ENSDARG00000039456 acbd6 acyl-Coenzyme A binding domain containing 6 0 0 G. maculatum ENSDARG00000042630 hebp2 heme binding protein 2 0 0 G. maculatum ENSDARG00000040555 bckdha branched chain keto acid dehydrogenase E1, alpha polypeptide 0 0 G. maculatum ENSDARG00000040620 psmg1 proteasome (prosome, macropain) assembly chaperone 1 0 0 G. maculatum ENSDARG00000040730 wdr75 WD repeat domain 75 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000041088 tufm Tu translation , mitochondrial 0.003994488 0.017303707 G. maculatum ENSDARG00000041338 mitochondrial ribosomal protein L15 0 0 G. maculatum ENSDARG00000041362 chmp7 CHMP family, member 7 0 0 G. maculatum ENSDARG00000041575 trmt10c tRNA methyltransferase 10 homolog C (S. cerevisiae) 0 0 G. maculatum ENSDARG00000041830 tsn translin 0 0 G. maculatum ENSDARG00000042458 rfc4 replication factor C (activator 1) 4 0 0 G. maculatum ENSDARG00000042780 apoba apolipoprotein Ba 0 0 G. maculatum ENSDARG00000042821 agps alkylglycerone phosphate synthase 0 0 G. maculatum ENSDARG00000043105 qtrt1 queuine tRNA-ribosyltransferase 1 0 0 G. maculatum ENSDARG00000043457 gapdh glyceraldehyde-3-phosphate dehydrogenase 0.004176678 0.017938294 G. maculatum ENSDARG00000043467 ndufb11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 0 0 G. maculatum ENSDARG00000043502 ccdc124 coiled-coil domain containing 124 0 0 G. maculatum ENSDARG00000017864 txnrd1 thioredoxin reductase 1 0 0 G. maculatum ENSDARG00000044097 stoml2 stomatin (EPB72)-like 2 0 0 G. maculatum ENSDARG00000044402 nop16 NOP16 nucleolar protein homolog (yeast) 0 0 G. maculatum ENSDARG00000044405 ttc4 tetratricopeptide repeat domain 4 0.000856454 0.003948332 G. maculatum ENSDARG00000044853 rrp7a ribosomal RNA processing 7 homolog A (S. cerevisiae) 0 0 G. maculatum ENSDARG00000045399 cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.000633581 0.002947912 TAF3 RNA polymerase II, TATA box binding protein G. maculatum ENSDARG00000045513 taf3 0 0 (TBP)-associated facto G. maculatum ENSDARG00000045516 itih2 inter-alpha (globulin) inhibitor H2 0 0 G. maculatum ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 0 0 G. maculatum ENSDARG00000045658 msrb3 methionine sulfoxide reductase B3 0.005573157 0.023733147 G. maculatum ENSDARG00000045692 pphln1 periphilin 1 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000045847 si:ch211-214j24.10 si:ch211-214j24.10 0 0 G. maculatum ENSDARG00000045976 sidt2 SID1 transmembrane family, member 2 0 0 G. maculatum ENSDARG00000056165 C19H6orf136 6 open 136 0 0 G. maculatum ENSDARG00000052696 bdh2 3-hydroxybutyrate dehydrogenase, type 2 0 0 G. maculatum ENSDARG00000052815 alad aminolevulinate dehydratase 0 0 G. maculatum ENSDARG00000014945 znf598 zinc finger protein 598 0 0 G. maculatum ENSDARG00000070261 crlf3 cytokine receptor-like factor 3 0 0 G. maculatum ENSDARG00000054540 imp4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) 0 0 G. maculatum ENSDARG00000054807 sec13 SEC13 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000055314 mcmbp minichromosome maintenance complex binding protein 0 0 G. maculatum ENSDARG00000055472 nubp1 nucleotide binding protein 1 (MinD homolog, E. coli) 0.006367526 0.027001534 G. maculatum ENSDARG00000055477 pelo pelota homolog (Drosophila) 0 0 G. maculatum ENSDARG00000056167 hspe1 heat shock 10 protein 1 (chaperonin 10) 0 0 CCZ1 vacuolar protein trafficking and biogenesis associated G. maculatum ENSDARG00000056559 ccz1 0 0 homolog (S. cerevisiae) G. maculatum ENSDARG00000071671 nudt22 nudix (nucleoside diphosphate linked moiety X)-type motif 22 0 0 hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A G. maculatum ENSDARG00000057147 hadhb thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta 0 0 subunit G. maculatum ENSDARG00000058005 hgd homogentisate 1,2-dioxygenase 0 0 G. maculatum ENSDARG00000058297 timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0 0 G. maculatum ENSDARG00000058560 adrm1 adhesion regulating molecule 1 0 0 G. maculatum ENSDARG00000058622 bloc1s5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0 0 G. maculatum ENSDARG00000059394 SUGCT succinyl-CoA:glutarate-CoA transferase 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000076486 acp1 acid phosphatase 1, soluble 0 0 G. maculatum ENSDARG00000033259 dis3l2 DIS3 mitotic control homolog (S. cerevisiae)-like 2 0 0 G. maculatum ENSDARG00000059866 cactin cactin 0.002312346 0.010237479 G. maculatum ENSDARG00000060501 dpcd deleted in a mouse model of primary ciliary dyskinesia 0 0 G. maculatum ENSDARG00000060554 mut methylmalonyl Coenzyme A mutase 0 0 G. maculatum ENSDARG00000079605 prmt5 protein arginine methyltransferase 5 0 0 G. maculatum ENSDARG00000061761 opa3 optic atrophy 3 0 0 G. maculatum ENSDARG00000062209 mitochondrial ribosomal protein S5 0.000516566 0.002425927 G. maculatum ENSDARG00000062837 spata13 spermatogenesis associated 13 0 0 G. maculatum ENSDARG00000067607 srebf1 sterol regulatory element binding transcription factor 1 0 0 G. maculatum ENSDARG00000063572 perp PERP, TP53 apoptosis effector 0 0 G. maculatum ENSDARG00000063624 gfm1 G elongation factor, mitochondrial 1 0 0 G. maculatum ENSDARG00000063663 CR855307.1 Uncharacterized protein 0 0 G. maculatum ENSDARG00000068261 pros1 protein S (alpha) 0 0 G. maculatum ENSDARG00000068289 eukaryotic translation initiation factor 3, subunit K 0 0 G. maculatum ENSDARG00000067805 ggcx gamma-glutamyl carboxylase 0 0 G. maculatum ENSDARG00000069092 xrn2 5'-3' exoribonuclease 2 0.001150022 0.005159695 G. maculatum ENSDARG00000069099 tmco1 transmembrane and coiled-coil domains 1 0 0 G. maculatum ENSDARG00000069113 dbn1 drebrin 1 7.32E-07 3.55E-06 G. maculatum ENSDARG00000069313 oxa1l oxidase (cytochrome c) assembly 1-like 0 0 G. maculatum ENSDARG00000041085 C18H15orf38 C15orf38-AP3S2 readthrough 0 0 G. maculatum ENSDARG00000003382 cwc25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000019231 spna2 spectrin alpha 2 0 0 G. maculatum ENSDARG00000069977 C11H12orf10 chromosome 12 open reading frame 10 0.003311249 0.014406081 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000069980 lman1 lectin, mannose-binding, 1 0 0 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A G. maculatum ENSDARG00000070029 ehhadh 0 0 dehydrogenase G. maculatum ENSDARG00000019743 dctn1a dynactin 1a 0 0 G. maculatum ENSDARG00000070284 sft2d3 SFT2 domain containing 3 0 0 G. maculatum ENSDARG00000070387 NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 0 0 G. maculatum ENSDARG00000057255 emc1 ER membrane protein complex subunit 1 0 0 G. maculatum ENSDARG00000032277 rars2 arginyl-tRNA synthetase 2, mitochondrial (putative) 0 0 G. maculatum ENSDARG00000071017 nt5e 5'-nucleotidase, ecto (CD73) 0.001483531 0.006597116 G. maculatum ENSDARG00000071087 slc35b4 solute carrier family 35, member B4 0.008916219 0.037492885 G. maculatum ENSDARG00000071116 eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 0.000929155 0.004225343 G. maculatum ENSDARG00000071500 fam207a family with sequence similarity 207, member A 0 0 G. maculatum ENSDARG00000071774 eukaryotic translation elongation factor 1 epsilon 1 3.83E-05 0.000183951 G. maculatum ENSDARG00000079687 rnf10 ring finger protein 10 0 0 G. maculatum ENSDARG00000011299 blzf1 basic leucine zipper nuclear factor 1 0 0 G. maculatum ENSDARG00000076066 6-Mar membrane-associated ring finger (C3HC4) 6 0.011285612 0.04667506 G. maculatum ENSDARG00000075677 mitochondrial ribosomal protein L17 0 0 G. maculatum ENSDARG00000034178 cpsf1 cleavage and polyadenylation specific factor 1 0 0 G. maculatum ENSDARG00000075936 sugp1 SURP and G patch domain containing 1 0 0 G. maculatum ENSDARG00000074060 MAP3K14 (2 of 2) mitogen-activated protein kinase kinase kinase 14 0.000228524 0.001083331 G. maculatum ENSDARG00000012820 nop56 NOP56 ribonucleoprotein homolog 0.000535504 0.002503168 G. maculatum ENSDARG00000014817 ranbp1 RAN binding protein 1 0 0 G. maculatum ENSDARG00000075693 NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0 0 G. maculatum ENSDARG00000003384 akap17a A kinase (PRKA) anchor protein 17A 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value CZv9_NA991H1orf G. maculatum ENSDARG00000077566 open reading frame 52 0 0 52 G. maculatum ENSDARG00000075215 vetz vezatin, adherens junctions transmembrane protein 0 0 G. maculatum ENSDARG00000077265 WDR89 WD repeat domain 89 0 0 G. maculatum ENSDARG00000074028 ZNFX1 zinc finger, NFX1-type containing 1 0 0 G. maculatum ENSDARG00000077607 dus2 dihydrouridine synthase 2 0.010413172 0.043424221 G. maculatum ENSDARG00000063069 gripap1 GRIP1 associated protein 1 0 0 C22H10orf76 (1 of G. maculatum ENSDARG00000030790 chromosome 10 open reading frame 76 0 0 2) G. maculatum ENSDARG00000075025 cdc123 cell division cycle 123 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000079870 ncdn neurochondrin 0 0 G. maculatum ENSDARG00000040005 scfd2 sec1 family domain containing 2 0 0 G. maculatum ENSDARG00000077081 slc38a10 solute carrier family 38, member 10 0 0 G. maculatum ENSDARG00000091079 MALSU1 mitochondrial assembly of ribosomal large subunit 1 0 0 G. maculatum ENSDARG00000029215 ube2z ubiquitin-conjugating enzyme E2Z 0 0 G. maculatum ENSDARG00000016177 eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 0 0 G. maculatum ENSDARG00000091001 mycbp c-myc binding protein 0.003289546 0.014373886 G. maculatum ENSDARG00000037965 srrm2 serine/arginine repetitive matrix 2 6.01E-05 0.000287523 G. maculatum ENSDARG00000035564 dgcr8 DiGeorge syndrome critical region gene 8 0 0 G. maculatum ENSDARG00000043624 pqlc2 PQ loop repeat containing 2 0 0 G. maculatum ENSDARG00000059835 zfyve27 zinc finger, FYVE domain containing 27 0 0 G. maculatum ENSDARG00000053504 cog3 component of oligomeric golgi complex 3 0 0 G. maculatum ENSDARG00000069373 crcp calcitonin gene-related peptide-receptor component protein 0 0 G. maculatum ENSDARG00000008735 atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value G. maculatum ENSDARG00000089976 spcs3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000061770 abcd4 ATP-binding cassette, sub-family D (ALD), member 4 0 0 G. maculatum ENSDARG00000040815 tsku tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) 0 0 G. maculatum ENSDARG00000031153 mrps15 mitochondrial ribosomal protein S15 0 0 G. maculatum ENSDARG00000089453 PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0 0 G. maculatum ENSDARG00000016443 eukaryotic translation initiation factor 3, subunit C 0 0 G. maculatum ENSDARG00000087950 IWS1 IWS1 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000001244 srrm1 serine/arginine repetitive matrix 1 0.000928678 0.004225343 G. maculatum ENSDARG00000068415 ptgesl prostaglandin E synthase 2-like 0 0 G. maculatum ENSDARG00000090401 CABZ01020840.1 Uncharacterized protein 0 0 G. maculatum ENSDARG00000037935 aldh16a1 aldehyde dehydrogenase 16 family, member A1 0 0 G. maculatum ENSDARG00000051800 fnbp4 formin binding protein 4 0 0 G. maculatum ENSDARG00000039400 polr1c polymerase (RNA) I polypeptide C 0 0 G. maculatum ENSDARG00000089828 C12H10orf88 chromosome 10 open reading frame 88 0 0 G. maculatum ENSDARG00000087545 fbxo42 F-box protein 42 0 0 G. maculatum ENSDARG00000038870 slu7 SLU7 splicing factor homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000042005 elp3 elongation protein 3 homolog (S. cerevisiae) 0 0 G. maculatum ENSDARG00000062374 leng9 leukocyte receptor cluster (LRC) member 9 0 0 G. maculatum ENSDARG00000037713 pcnp PEST proteolytic signal containing nuclear protein 0 0 G. maculatum ENSDARG00000020527 nup62l nucleoporin 62 like 0 0 G. maculatum ENSDARG00000056258 cdc27 cell division cycle 27 0 0 G. maculatum ENSDARG00000063344 fam162a family with sequence similarity 162, member A 0 0 growth arrest and DNA-damage-inducible, gamma interacting G. maculatum ENSDARG00000039338 gadd45gip1 0 0 protein 1 Lineage Gene ID Gene name Gene description P-value Corrected P-value protein kinase, interferon-inducible double stranded RNA dependent G. maculatum ENSDARG00000076718 prkra 0 0 activator G. maculatum ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0 0 G. maculatum ENSDARG00000025554 WDR83OS WD repeat domain 83 opposite strand 0 0 G. maculatum ENSDARG00000062916 mitochondrial ribosomal protein L37 0 0 G. maculatum ENSDARG00000042977 nfil3 nuclear factor, interleukin 3 regulated 0.003042945 0.013354407 G. maculatum ENSDARG00000014646 aoc2 amine oxidase, copper containing 2 0 0 G. maculatum ENSDARG00000057299 pbdc1 polysaccharide biosynthesis domain containing 1 0 0 G. maculatum ENSDARG00000042933 bloc1s6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0 0 G. maculatum ENSDARG00000074170 FBXO4 F-box protein 4 0 0 G. maculatum ENSDARG00000091931 gpatch4 G patch domain containing 4 4.09E-07 1.99E-06 G. maculatum ENSDARG00000004343 nelfe negative elongation factor complex member E 0.000133109 0.000634003 G. maculatum ENSDARG00000095817 ZNHIT6 zinc finger, HIT-type containing 6 0 0 G. maculatum ENSDARG00000051853 galns galactosamine (N-acetyl)-6-sulfate sulfatase 0 0 G. maculatum ENSDARG00000096597 ATP5SL ATP5S-like 0 0 G. maculatum ENSDARG00000096668 MZT1 mitotic spindle organizing protein 1 0 0 G. maculatum ENSDARG00000075953 ddx24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 0 0 G. maculatum ENSDARG00000003675 cryl1 crystallin, lambda 1 0 0 G. maculatum ENSDARG00000091932 C19H6orf47 chromosome 6 open reading frame 47 0 0 P. sinensis ENSDARG00000008502 pno1 partner of NOB1 homolog (S. cerevisiae) 7.51E-06 0.000503583

P. sinensis ENSDARG00000009470 hnf1a HNF1 homeobox a 0.000340827 0.013761998

P. sinensis ENSDARG00000018049 sf3b2 splicing factor 3b, subunit 2 0.001593995 0.044219606

P. sinensis ENSDARG00000012947 SKA2 spindle and kinetochore associated complex subunit 2 5.37E-05 0.003084137 Lineage Gene ID Gene name Gene description P-value Corrected P-value

P. sinensis ENSDARG00000015851 pnn pinin, desmosome associated protein 0 0

P. sinensis ENSDARG00000009449 PDCL3 phosducin-like 3 0.000249976 0.011172538

P. sinensis ENSDARG00000013961 slc31a1 solute carrier family 31 (copper transporters), member 1 0.000567764 0.020762079

P. sinensis ENSDARG00000052462 pisd phosphatidylserine decarboxylase 0.000121686 0.006315896

P. sinensis ENSDARG00000021120 ndc1 NDC1 transmembrane nucleoporin 0.001060864 0.031609803

P. sinensis ENSDARG00000012777 nucks1b nuclear casein kinase and cyclin-dependent kinase substrate 1b 5.00E-10 1.01E-07

P. sinensis ENSDARG00000009754 zc3h11a zinc finger CCCH-type containing 11A 0 0

P. sinensis ENSDARG00000020323 nup153 nucleoporin 153 0 0

P. sinensis ENSDARG00000022232 ppan peter pan homolog (Drosophila) 9.69E-06 0.000623841

P. sinensis ENSDARG00000027182 rnf25 ring finger protein 25 4.78E-06 0.000349702

P. sinensis ENSDARG00000023111 plg plasminogen 0.000321596 0.013761998

P. sinensis ENSDARG00000033987 rsrc1 arginine/serine-rich coiled-coil 1 0.000444964 0.017046359

P. sinensis ENSDARG00000015179 mfsd8 major facilitator superfamily domain containing 8 0.000633833 0.022170359

P. sinensis ENSDARG00000035264 riok2 RIO kinase 2 (yeast) 0.000190917 0.0093101

P. sinensis ENSDARG00000035763 CABZ01086801.1 Uncharacterized protein 0.000336818 0.013761998

P. sinensis ENSDARG00000035853 cdkn2aip CDKN2A interacting protein 0.000193279 0.0093101

P. sinensis ENSDARG00000040072 scpep1 serine carboxypeptidase 1 4.10E-06 0.000329443

P. sinensis ENSDARG00000040350 rpp38 ribonuclease P/MRP 38 subunit 5.39E-06 0.000376961

P. sinensis ENSDARG00000040666 nifk nucleolar protein interacting with the FHA domain of MKI67 0.000196733 0.0093101

P. sinensis ENSDARG00000040730 wdr75 WD repeat domain 75 0 0 Lineage Gene ID Gene name Gene description P-value Corrected P-value

P. sinensis ENSDARG00000058257 slc39a1 solute carrier family 39 (zinc transporter), member 1 9.28E-07 8.78E-05

P. sinensis ENSDARG00000042724 supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.000398418 0.015635477

P. sinensis ENSDARG00000042821 agps alkylglycerone phosphate synthase 0.001397139 0.039438538

P. sinensis ENSDARG00000042962 dgcr2 DiGeorge syndrome critical region gene 2 4.65E-06 0.000349702

P. sinensis ENSDARG00000043502 ccdc124 coiled-coil domain containing 124 0.000342126 0.013761998 ribosomal RNA processing 9, small subunit (SSU) processome P. sinensis ENSDARG00000041991 rrp9 0.00021945 0.010088407 component, homolog (yeast) P. sinensis ENSDARG00000045249 nif3l1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 1.62E-05 0.000992187

P. sinensis ENSDARG00000027310 LSP1 lymphocyte-specific protein 1 0 0

P. sinensis ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 2.47E-06 0.000209085

P. sinensis ENSDARG00000051888 ist1 increased sodium tolerance 1 homolog (yeast) 2.93E-07 3.14E-05

P. sinensis ENSDARG00000053225 gnl2 guanine nucleotide binding protein-like 2 (nucleolar) 0.000727843 0.023899971

P. sinensis ENSDARG00000054191 pgk1 phosphoglycerate kinase 1 0.001264717 0.036998706

P. sinensis ENSDARG00000055868 RSL1D1 ribosomal L1 domain containing 1 0 0

P. sinensis ENSDARG00000076486 acp1 acid phosphatase 1, soluble 4.45E-08 5.97E-06

P. sinensis ENSDARG00000059866 cactin cactin 6.40E-08 7.92E-06

P. sinensis ENSDARG00000019707 C21H9orf114 chromosome 9 open reading frame 114 0.000632891 0.022170359

P. sinensis ENSDARG00000070607 mrpl36 mitochondrial ribosomal protein L36 8.44E-05 0.004524991

P. sinensis ENSDARG00000071087 slc35b4 solute carrier family 35, member B4 2.02E-06 0.000180208

P. sinensis ENSDARG00000079687 rnf10 ring finger protein 10 1.78E-07 2.04E-05 Lineage Gene ID Gene name Gene description P-value Corrected P-value

P. sinensis ENSDARG00000074060 MAP3K14 (2 of 2) mitogen-activated protein kinase kinase kinase 14 1.05E-08 1.54E-06

P. sinensis ENSDARG00000007901 crnkl1 crooked neck pre-mRNA splicing factor-like 1 (Drosophila) 0.000934937 0.028929108

P. sinensis ENSDARG00000003384 akap17a A kinase (PRKA) anchor protein 17A 7.93E-05 0.004400199

P. sinensis ENSDARG00000078338 XPO5 exportin 5 1.66E-05 0.000992187

P. sinensis ENSDARG00000016345 ncoa5 nuclear receptor coactivator 5 0 0

P. sinensis ENSDARG00000090219 wdr45 WD repeat domain 45 0.000683201 0.023388732 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. P. sinensis ENSDARG00000008947 rtf1 0.000722669 0.023899971 cerevisiae) P. sinensis ENSDARG00000043970 lrpprc leucine-rich PPR-motif containing 0.000931196 0.028929108

P. sinensis ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 1.00E-09 1.79E-07

P. sinensis ENSDARG00000003189 psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.000511911 0.019154977

P. sinensis ENSDARG00000059634 thumpd3 THUMP domain containing 3 2.00E-09 3.22E-07

P. sinensis ENSDARG00000092836 jmy junction mediating and regulatory protein, p53 cofactor 0.000850888 0.027381576

P. sinensis ENSDARG00000074170 FBXO4 F-box protein 4 0.001304361 0.037477087

P. sinensis ENSDARG00000091931 gpatch4 G patch domain containing 4 4.33E-07 4.35E-05

P. sinensis ENSDARG00000004343 nelfe negative elongation factor complex member E 0.001048829 0.031609803 P. macrotrema ENSDARG00000020218 amfr autocrine motility factor receptor 0 0 ATP synthase, H+ transporting, mitochondrial F1 complex, O P. macrotrema ENSDARG00000001788 atp5o 0.00042067 0.01618576 subunit P. macrotrema ENSDARG00000021107 sf3a2 splicing factor 3a, subunit 2 9.04E-05 0.004424632 P. macrotrema ENSDARG00000018904 cstf3 cleavage stimulation factor, 3' pre-RNA, subunit 3 0.000358011 0.014463624 Lineage Gene ID Gene name Gene description P-value Corrected P-value P. macrotrema ENSDARG00000011841 atp5l ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g 0.00094061 0.029231265 P. macrotrema ENSDARG00000007955 iars isoleucyl-tRNA synthetase 0.000107783 0.005122839 P. macrotrema ENSDARG00000015851 pnn pinin, desmosome associated protein 3.33E-05 0.001793329 P. macrotrema ENSDARG00000013478 rrp15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0.000122756 0.005667797 P. macrotrema ENSDARG00000021439 ncoa4 nuclear receptor coactivator 4 3.00E-09 3.73E-07 P. macrotrema ENSDARG00000002710 ncl nucleolin 0.001371119 0.038872412 P. macrotrema ENSDARG00000016080 nob1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0 0 P. macrotrema ENSDARG00000013961 slc31a1 solute carrier family 31 (copper transporters), member 1 2.46E-05 0.001422282 P. macrotrema ENSDARG00000022675 otud6b OTU domain containing 6B 0.001677695 0.044445166 P. macrotrema ENSDARG00000024116 vamp8 vesicle-associated membrane protein 8 (endobrevin) 5.58E-05 0.002907028 P. macrotrema ENSDARG00000027046 scyl3 SCY1-like 3 (S. cerevisiae) 0 0 P. macrotrema ENSDARG00000011186 zfpl1 zinc finger protein-like 1 2.05E-08 2.37E-06 P. macrotrema ENSDARG00000028517 hbp1 HMG-box transcription factor 1 0.000928284 0.029231265 P. macrotrema ENSDARG00000031261 sap30bp SAP30 binding protein 8.61E-07 6.95E-05 P. macrotrema ENSDARG00000032769 slc38a9 solute carrier family 38, member 9 1.09E-07 1.04E-05 P. macrotrema ENSDARG00000075380 kri1 KRI1 homolog 0.000662282 0.022771211 P. macrotrema ENSDARG00000034777 txn2 thioredoxin 2 8.30E-08 8.38E-06 P. macrotrema ENSDARG00000058221 ugcg UDP-glucose ceramide glucosyltransferase 0.001461277 0.040024129 P. macrotrema ENSDARG00000013058 ascc2 activating signal cointegrator 1 complex subunit 2 0.00141277 0.039362681 P. macrotrema ENSDARG00000035570 C5H9orf85 chromosome 9 open reading frame 85 0.000568166 0.020403454 P. macrotrema ENSDARG00000035853 cdkn2aip CDKN2A interacting protein 2.29E-05 0.001422018 P. macrotrema ENSDARG00000040666 nifk nucleolar protein interacting with the FHA domain of MKI67 0.000393248 0.015499726 P. macrotrema ENSDARG00000040853 shoc2 soc-2 suppressor of clear homolog (C. elegans) 1.14E-06 8.40E-05 P. macrotrema ENSDARG00000041088 tufm Tu translation elongation factor, mitochondrial 0.001750829 0.045634498 Lineage Gene ID Gene name Gene description P-value Corrected P-value mediator of RNA polymerase II transcription, subunit 18 homolog P. macrotrema ENSDARG00000041237 med18 3.25E-05 0.001793329 (yeast) P. macrotrema ENSDARG00000042344 trmt6 tRNA methyltransferase 6 homolog (S. cerevisiae) 0.000753428 0.024847731 P. macrotrema ENSDARG00000043854 ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 5.00E-10 8.08E-08 P. macrotrema ENSDARG00000006666 BUD13 BUD13 homolog (S. cerevisiae) 0 0 ribosomal RNA processing 9, small subunit (SSU) processome P. macrotrema ENSDARG00000041991 rrp9 0.00025145 0.010693221 component, homolog (yeast) P. macrotrema ENSDARG00000045249 nif3l1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 0 0 P. macrotrema ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 0.000653476 0.022771211 P. macrotrema ENSDARG00000045847 si:ch211-214j24.10 si:ch211-214j24.10 6.57E-06 0.000424459 P. macrotrema ENSDARG00000052344 tbl3 transducin (beta)-like 3 0.000506543 0.018603943 P. macrotrema ENSDARG00000060494 eprs glutamyl-prolyl-tRNA synthetase 0 0 P. macrotrema ENSDARG00000055743 ankrd54 ankyrin repeat domain 54 0.001661142 0.044445166 P. macrotrema ENSDARG00000070097 vimp VCP-interacting membrane protein 0.0004467 0.016787591 P. macrotrema ENSDARG00000061023 C8H17orf59 chromosome 17 open reading frame 59 1.50E-09 2.20E-07 P. macrotrema ENSDARG00000061231 tinagl1 tubulointerstitial nephritis antigen-like 1 0.000279927 0.011599006 P. macrotrema ENSDARG00000062834 ecsit ECSIT homolog (Drosophila) 3.69E-07 3.31E-05 P. macrotrema ENSDARG00000063195 pxk PX domain containing serine/threonine kinase 0.001064649 0.032461751 P. macrotrema ENSDARG00000045207 camlg calcium modulating ligand 9.54E-07 7.34E-05 P. macrotrema ENSDARG00000013670 hyou1 hypoxia up-regulated 1 2.95E-08 3.18E-06 P. macrotrema ENSDARG00000069980 lman1 lectin, mannose-binding, 1 0.000217545 0.009501425 P. macrotrema ENSDARG00000079687 rnf10 ring finger protein 10 6.04E-06 0.000406693 P. macrotrema ENSDARG00000077614 C13H6orf203 chromosome 6 open reading frame 203 0.000178752 0.008023979 P. macrotrema ENSDARG00000078008 ATG7 autophagy related 7 2.43E-05 0.001422282 Lineage Gene ID Gene name Gene description P-value Corrected P-value P. macrotrema ENSDARG00000014817 ranbp1 RAN binding protein 1 0.001847976 0.047402038 P. macrotrema ENSDARG00000003384 akap17a A kinase (PRKA) anchor protein 17A 1.32E-06 9.24E-05 P. macrotrema ENSDARG00000079881 TCAIM T cell activation inhibitor, mitochondrial 0 0 excision repair cross-complementing rodent repair deficiency, P. macrotrema ENSDARG00000002402 ercc3 0.001202327 0.035980749 complementation group 3 P. macrotrema ENSDARG00000044567 ttc1 tetratricopeptide repeat domain 1 0.000678777 0.022852159 P. macrotrema ENSDARG00000087194 agxt2 alanine-glyoxylate aminotransferase 2 0.001331459 0.038872412 P. macrotrema ENSDARG00000043970 lrpprc leucine-rich PPR-motif containing 7.14E-07 6.07E-05 P. macrotrema ENSDARG00000030241 vbp1 von Hippel-Lindau binding protein 1 0.000901794 0.029145982 P. macrotrema ENSDARG00000070452 tmem66 transmembrane protein 66 0 0 P. macrotrema ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0 0 P. macrotrema ENSDARG00000074170 FBXO4 F-box protein 4 0.001365027 0.038872412 P. macrotrema ENSDARG00000091931 gpatch4 G patch domain containing 4 3.00E-09 3.73E-07 P. macrotrema ENSDARG00000075953 ddx24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 6.80E-05 0.003434934 P. fulvidraco ENSDARG00000011521 upb1 ureidopropionase, beta 5.00E-10 1.17E-07 P. fulvidraco ENSDARG00000052623 bsdc1 BSD domain containing 1 0.000651643 0.026570743 P. fulvidraco ENSDARG00000021107 sf3a2 splicing factor 3a, subunit 2 5.12E-04 0.023201337 P. fulvidraco ENSDARG00000018049 sf3b2 splicing factor 3b, subunit 2 0.000257404 0.013542745 P. fulvidraco ENSDARG00000018020 pepd peptidase D 0.001232409 0.042767197 P. fulvidraco ENSDARG00000012947 SKA2 spindle and kinetochore associated complex subunit 2 0.00016035 0.009686298 P. fulvidraco ENSDARG00000002710 ncl nucleolin 0.00E+00 0 P. fulvidraco ENSDARG00000001929 pink1 PTEN induced putative kinase 1 0.001019035 0.036550338 P. fulvidraco ENSDARG00000013961 slc31a1 solute carrier family 31 (copper transporters), member 1 0.000306229 0.015135112 P. fulvidraco ENSDARG00000018491 pdia4 protein disulfide isomerase associated 4 5.49E-04 0.024214928 Lineage Gene ID Gene name Gene description P-value Corrected P-value P. fulvidraco ENSDARG00000004727 cmss1 cms1 ribosomal small subunit homolog (yeast) 3.11E-07 4.22E-05 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 P. fulvidraco ENSDARG00000004527 pin4 7.05E-08 1.15E-05 (parvulin) P. fulvidraco ENSDARG00000004891 pex19 peroxisomal biogenesis factor 19 1.11E-04 0.006943449 P. fulvidraco ENSDARG00000025421 tdrd3 tudor domain containing 3 9.04E-05 0.005895119 P. fulvidraco ENSDARG00000009754 zc3h11a zinc finger CCCH-type containing 11A 4.91E-05 0.003483568 P. fulvidraco ENSDARG00000025269 pdcd6ip programmed cell death 6 interacting protein 6.22E-04 0.026012882 P. fulvidraco ENSDARG00000020323 nup153 nucleoporin 153 3.39E-07 4.25E-05 P. fulvidraco ENSDARG00000027046 scyl3 SCY1-like 3 (S. cerevisiae) 1.80E-05 0.001395903 P. fulvidraco ENSDARG00000058221 ugcg UDP-glucose ceramide glucosyltransferase 0.000506149 0.023201337 asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase P. fulvidraco ENSDARG00000031202 alg11 5.00E-10 1.17E-07 homolog (yeast) P. fulvidraco ENSDARG00000029043 nupl2 nucleoporin like 2 0.000381231 0.018287851 P. fulvidraco ENSDARG00000033735 ncf1 neutrophil cytosolic factor 1 6.11E-06 0.000553589 P. fulvidraco ENSDARG00000035763 CABZ01086801.1 Uncharacterized protein 6.77E-07 7.36E-05 P. fulvidraco ENSDARG00000051971 arl6ip4 ADP-ribosylation-like factor 6 interacting protein 4 0.000983523 0.036457391 P. fulvidraco ENSDARG00000037259 ndufb6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 7.39E-04 0.028482362 P. fulvidraco ENSDARG00000038905 hectd3 HECT domain containing 3 0.00030033 0.015135112 P. fulvidraco ENSDARG00000075768 sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.21E-06 0.000116473 P. fulvidraco ENSDARG00000027310 LSP1 lymphocyte-specific protein 1 5.00E-10 1.17E-07 P. fulvidraco ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 8.56E-07 8.73E-05 P. fulvidraco ENSDARG00000054574 znhit1 zinc finger, HIT-type containing 1 0.001439472 0.048912042 P. fulvidraco ENSDARG00000056099 gtf2h5 general transcription factor IIH, polypeptide 5 2.13E-05 0.001579846 P. fulvidraco ENSDARG00000059836 ddit3 DNA-damage-inducible transcript 3 1.00E-09 2.04E-07 Lineage Gene ID Gene name Gene description P-value Corrected P-value P. fulvidraco ENSDARG00000059866 cactin cactin 0 0 P. fulvidraco ENSDARG00000062335 nudt14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 5.80E-05 0.003940088 P. fulvidraco ENSDARG00000062506 zc3h18 zinc finger CCCH-type containing 18 0.0002356 0.012867475 P. fulvidraco ENSDARG00000063252 prcc papillary renal cell carcinoma (translocation-associated) 0.00103085 0.036550338 P. fulvidraco ENSDARG00000013670 hyou1 hypoxia up-regulated 1 0.000678452 0.026989152 P. fulvidraco ENSDARG00000032277 rars2 arginyl-tRNA synthetase 2, mitochondrial (putative) 0.000750915 0.028482362 P. fulvidraco ENSDARG00000076761 ftsj FtsJ homolog 3 (E. coli) 5.00E-10 1.17E-07 P. fulvidraco ENSDARG00000068814 spata2l spermatogenesis associated 2-like 0.000202414 0.011790616 P. fulvidraco ENSDARG00000015653 tnip1 TNFAIP3 interacting protein 1 9.82E-06 0.000801106 P. fulvidraco ENSDARG00000075936 sugp1 SURP and G patch domain containing 1 1.50E-09 2.72E-07 P. fulvidraco ENSDARG00000078418 meaf6 MYST/Esa1-associated factor 6 1.08E-07 1.60E-05 P. fulvidraco ENSDARG00000077081 slc38a10 solute carrier family 38, member 10 0.00023668 0.012867475 P. fulvidraco ENSDARG00000057648 dnttip2 deoxynucleotidyltransferase, terminal, interacting protein 2 0.00058004 0.024895906 P. fulvidraco ENSDARG00000093188 si:dkey-75a21.2 si:dkey-75a21.2 6.51E-07 7.36E-05 P. fulvidraco ENSDARG00000062916 mrpl37 mitochondrial ribosomal protein L37 7.25E-06 0.000621969 P. fulvidraco ENSDARG00000075953 ddx24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 0 0