Therapeutic Microbiology PROBIOTICS AND RELATED STRATEGIES This page intentionally left blank Therapeutic Microbiology PROBIOTICS AND RELATED STRATEGIES Edited by James Versalovic Department of Pathology, Texas Childrens Hospital, Houston Michael Wilson Eastman Dental Institute, University College London, London, United Kingdom Washington, DC Copyright © 2008 ASM Press American Society for Microbiology 1752 N Street, N.W. Washington, DC 20036-2904 Library of Congress Cataloging-in-Publication Data Therapeutic microbiology : probiotics and related strategies / [edited by] James Versalovic, Michael Wilson. p. ; cm. Includes bibliographical references and index. ISBN 978-1-55581-403-8 1. Probiotics. 2. Microorganisms—Therapeutic use. I. Versalovic, James. II. Wilson, Michael, 1947 Apr. 12– [DNLM: 1. Probiotics—therapeutic use. 2. Gastrointestinal Diseases—prevention & control. 3. Gastrointestinal Diseases—therapy. 4. Intestines—immunology. 5. Intestines—microbiology. QU 145.5 T398 2008] RM666.P835T54 2008 615Ј.329––dc22 2008016646 All Rights Reserved Printed in the United States of America 10 9 8 7 6 5 4 3 2 1 Address editorial correspondence to: ASM Press, 1752 N St., N.W., Washington, DC 20036-2904, U.S.A. Send orders to: ASM Press, P.O. Box 605, Herndon, VA 20172, U.S.A. Phone: 800-546-2416; 703-661-1593 Fax: 703-661-1501 Email:
[email protected] Online: estore.asm.org Contents Contributors ix Preface xv 1. Introduction 1 1 Introduction 3 Mary Ellen Sanders 2. Basic Biology 7 2.1. The Indigenous Microbiota 9 2 Role of the Indigenous Microbiota in Health and Disease 9 Gerald W. Tannock 2.2. Biology of Effector Organisms for Probiotic and Replacement Therapy 19 3 Lactobacilli 19 Covadonga Barbés 4 Bifi dobacteria: the Model Human Gut Commensal 35 Marco Ventura, Francesca Turroni, Angela Ribbera, Elena Foroni, and Douwe van Sinderen 5 Saccharomyces spp.