Circulation Journal Supplementary File Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp Circ J 2014; 78: 882 – 889 Long-Term Outcome of the Carpentier-Edwards Pericardial Valve in the Aortic Position in Japanese Patients Kenji Minakata, MD, PhD; Shiro Tanaka, PhD; Yohei Okawa, MD, PhD; Mitsuomi Shimamoto, MD, PhD; Tatsuo Kaneko, MD, PhD; Yoshiharu Takahara, MD, PhD; Hitoshi Yaku, MD, PhD; Kazuo Yamanaka, MD, PhD; Akihiko Usui, MD, PhD; Nobushige Tamura, MD, PhD; Ryuzo Sakata, MD, PhD

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Appendix S1. Participating Hospitals and Investigators Appendix S2. Independent Clinical Research Coordinators Cardiovascular Center Hokkaido Ohno Hospital (Sapporo), Gunma Car- Yui Kinoshita, Yumika Fujino, Miya Hanazawa (Research Institute for diovascular Center (Maebashi), Funabashi Municipal Medical Center Production Development, Kyoto, Japan). (Funabashi), Shizuoka City Shizuoka Hospital (Shizuoka), Nagoya Uni- versity Hospital (Nagoya), Tenri Hospital (Tenri), University Hospital, Kyoto Prefectural University of Medicine (Kyoto), Kyoto University Appendix S3. Independent Clinical Events Evaluation Committee Hospital (Kyoto), Kumamoto Central Hospital (Kumamoto). Takeshi Kimura, MD, PhD, Jun-ichi Tasaki, MD (Department of Cardiol- Shuichi Okonogi, MD (Maebashi), Hajime Matsuura, MD (Funabashi), ogy, Kyoto University Graduate School of Medicine), Riki Matsumoto, Yasuhiko Terai, MD (Shizuoka), Hiroki Hori, MD (Tenri), Kiyoshi Doi, MD, PhD (Department of Neurology, Kyoto University Graduate School MD (Kyoto), Shigeki Yanagi, MD (Kumamoto). of Medicine), Kazumichi Yoshida, MD, PhD (Department of Neurosur- gery, Kyoto University Graduate School of Medicine).

Table S1. Freedom From Events (%) Event 5 years (95% CI) 10 years (95% CI) 15 years (95% CI) All-cause death 78.9 (75.4–82.4) 56.8 (52.4–61.2) 36.2 (30.9–41.6) Valve-related death 98.1 (96.8–99.3) 93.1 (90.4–95.8) 90.8 (87.5–94.1) Thromboembolic event 96.8 (95.1–98.4) 92.3 (89.6–95.1) 87.5 (82.8–92.3) Bleeding event 95.8 (93.9–97.7) 90.3 (87.3–93.3) 83.2 (77.4–89.1) Prosthetic valve endocarditis 98.9 (97.9–99.9) 98.2 (96.9–99.6) 97.5 (95.6–99.4) Reoperation due to SVD 99.3 (98.6–100.0) 96.7 (94.7–98.6) 87.5 (81.4–93.6) Reoperation due to SVD (age ≥65) 99.3 (98.4–100.0) 97.4 (95.6–99.2) 94.4 (90.4–98.3) CI, confidence interval; SVD, structural valve deterioration.

Circulation Journal Vol.78, April 2014