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MPM XXX 2019 15-19 S E P T molecular parasitology meeting marine biological laboratory woods hole, ma 1 2019 - 30th Annual Molecular Parasitology Meeting Sunday, September 15 2:00-5:00p Registration Swope Center 5:00-6:30p Dinner Swope Dining Hall 6:45-7:00p Welcome to MPM Lillie Auditorium 7:00-9:00p Session I Lillie Auditorium 9:00-11:00p Mixer Swope Meigs Room Monday, September 16 7:00-8:30a Breakfast Swope Dining Hall 9:00-10:10a Session II Lillie Auditorium 10:10-10:30a Coffee Break 10:30-11:30a Session III Lillie Auditorium 11:30a-1:00p Lunch Swope Dining Hall 1:00-2:15p Session IV Lillie Auditorium 2:15-2:30p Coffee Break 2:30-3:30p Session V Lillie Auditorium 3:30-5:00p Free Time/ Parasite Games with Selina & Omar 5:00p-7:00p BBQ Dinner Swope Dining Hall 7:00-9:00p Poster Session: A Swope Center 8:00-10:00p Mixer Swope Meigs Room Tuesday, September 17 7:00-8:30a Breakfast Swope Dining Hall 9:00-10:15a Session VI Lillie Auditorium 10:15-10:30a Coffee Break 10:30-11:30a Session VII Lillie Auditorium 11:30-1:00p Lunch Swope Dining Hall 1:00-2:15p Session VIII Lillie Auditorium 2:15-2:30p Coffee Break 2:30-3:30P Session IX Lillie Auditorium 3:30-5:00p Free Time Power hour: 3pm-4pm with Kirk Deitsch and Nina Papavasiliou An informal session for all attendees to discuss challenges women face in science: Data on disparity will be presented, and then assigned to breakout groups to discuss and solicit solutions for group discussion. 5:00p-7:00p Dinner Swope Dining Hall 7:00-9:00p Poster Session: B Swope Center 8:00-10:00p Mixer Swope Meigs Room 2 Wednesday, September 18 7:00-8:30a Breakfast Swope Dining Hall 9:00-10:15a Session X Lillie Auditorium 10:15-10:30a Coffee Break 10:30-11:30a Session XI Lillie Auditorium 11:30-1:00p Lunch Swope Dining Hall 1:00-3:00p Free Time 3:00-5:00p Poster Session: C Swope Center 4:00-5:30p Mixer Swope Meigs Room 5:30p-7:00p Keynote Lecture Lillie Auditorium 7:30-9:00p Lobster Banquet Swope Dining Hall 9:00-12:00a Dance Party/Mixer Captain Kidd Thursday, September 19 7:00-8:30a Breakfast Swope Terrace 10:00a Housing Checkout by 10:00a 9:00-10:10a Session XII Lillie Auditorium 10:10-10:30a Coffee Break 10:30-11:30a Session XIII Lillie Auditorium 11:30-1:00p Lunch & Departure Swope Dinning Hall *Note: Please remove your Poster by Lunch time the day following your presentation. 3 Science at the 2019 Molecular Parasitology Meeting Code of Conduct PRINCIPLES: Scientific meetings are important mechanisms for rapid advancement and dissemination of new ways of thinking, particularly for pressing public health challenges such as parasitology. Clarity and openness from meeting participants is necessary for useful community feedback, appreciation, and debate. THE CODE: To meet the goals of this meeting, it is each presenter’s responsibility and duty to make claims that are exact and transparent. These claims should be supported with as much specific documentation as possible, within the time frame of the presentations. SPECIFIC EXAMPLES: Conclusive functional genetic studies should be accompanied by gene names and database references. Discovery of new inhibitors or drug candidates should be accompanied by structures and quantitative descriptions of potency and selectivity. New diagnostic approaches should be accompanied by actual names, structures, or signatures of key analytes, when known. It should be possible to evaluate the value of new experimental methods for manipulating cells or analyzing their content, based on the experimental details provided. WHY A CODE? The organizers merely offer some reminders for scientific conduct based on some time-proven principles. The 2007 MPM involved passionate pleas from many for more openness in some basic research presentations. Others argued for the need to protect potentially important intellectual property (IP). This simple code was assembled in close consultation with key leaders in the molecular parasitology community. INTELLECTUAL PROPERTY AND CHOICES: In an age of translational research, the community fully recognizes the need for IP protection. Important data, or an experimental approach, that is not ready for disclosure can be protected until it is time. Yet, one cannot have it both ways: Vague descriptions of critical data or method should not be the central part of one’s premature published abstract or public presentation. REWARDS AND PENALTIES: The MPM is organized and supported by practicing scientists who choose to engage. No individual has judicial powers. Abstracts and talks that lack specifics, and merely posture, may meet community-wide disappointment. In contrast, detailed presentations which offer new insights of general use have always been promoted and celebrated. We hope an understanding and regular observance of this code of conduct will add to another exciting scientific meeting. Boris Striepen, Manoj Duraisingh, Nina Papavasiliou 4 ACKNOWLEDGEMENTS: The organizers appreciate and thank the following: • Susan Waddington-Pilder (Penn) for organization • Omar Harb (Penn) and Selina Bopp (Harvard) for polling and activities • Caroline Keroack (Harvard) for T-Shirt design Site support at the MBL, Woods Hole, MA: • Nipam Patel, Director, Marine Biological Laboratory; • Kerri Mills and Paul Anderson for Conference support; • Cathy Ham, Suzanne Livingstone, Beth Sexany, Barbara Stackhouse and Nancy Hadway for Housing and the Front Office; • Erin Hummetolgu and Sodexo Dining Services staff; • Chad Baptiste, Jessica Berrios, Crystal Santiago, Cathy Hannigan, and all of the staff in Housekeeping; • Richard Boudreau of the IT/AV Department for Web booths and other support, and all the staff in the Information Technology Department. Award sponsors: • Travel Awards: Special thanks to all the participants who donated during registration. • The American Society for Tropical Medicine and Hygiene and Burroughs Wellcome Fund facilitated travel and speaking slots at ASTMH meetings. • The Bill and Melinda Gates Foundation supported travel in particular for attendees from disease endemic countries • Travel and Cash awards: PLos Pathogens and PLos Biology 5 In Memoriam: Paul T. Englund, Ph.D. 1938 - 2019 “Paul was the consummate scientist, mentor, colleague and human being.” Dr. Paul T. Englund, professor emeritus and Johns Hopkins scientist, passed away January 12, 2019. While most of Paul’s fifty- year career focused on research involving the African trypanosome, the many contributions he made had implications beyond the field of molecular and biochemical parasitology and have altered the way we think about important cellular processes. These include advances in understanding the biosynthetic pathway of GPI anchors and fatty acids and deep insight into DNA replication, particularly of mitochondrial DNAs in kinetoplastid parasites. Paul was a brilliant and creative scientist whose excitement and enthusiasm for research never diminished. The impact of this work has been recognized by his many awards including Paul being elected to the National Academy of Sciences in 2012. Paul's educational efforts included leadership, for seven years, of the NIH- funded Biochemistry, Cellular and Molecular Biology (BCMB) training program at John Hopkins, and co-directorship, of the Marine Biological Laboratory summer course in the Biology of Parasitism (1993-1994). In 2016, the remarkable contributions of his trainees and colleagues established an endowed Paul and Christine Englund Professorship in the Department of Biological Chemistry and an endowed lectureship in the Biology of Parasitism course at MBL. Paul’s influence and impact on molecular parasitology was immeasurable, not only because of his expertise and passion for science, but most importantly because of his thoughtful, nonjudgmental, supportive mentoring style. For many, the deep and booming voice of a question from the audience in Lilly auditorium was the first encounter they had with Paul. While this could initially be intimidating, the legion of trainees that passed through Paul’s lab as fellows or students will attest to the depth of Paul’s warmth and generosity. He encouraged curiosity, and celebrated successes, and he will be missed greatly. Michele Klingbell, James Morris and Jayne Raper 6 Molecular Parasitology Keynote Lectures 2019: When you come to a fork in the road, take it! New paradigms emerging from Leishmania glycobiology and virology Stephen Beverley, Washington University, St Louis 2018: The Hidden Life of African Trypanosomes Stephen L Hajduk, Department of Biochemistry & Molecular Biology University of Georgia 2017: African trypanosomes and the art of being social Isabel Roditi, Institute of Cell Biology, University of Bern 2016: Malaria sexual development: A challenging journey from the shadows into the spotlight Robert Sinden Emeritus Proefssor, Imperial College, London UK 2015: A Physician-scientist’s investigtion of amebiasis Bill Petri University of Virginia, Charlottesville, VA. 2014: Molecular Malariology and Global Health: Discoveries, Predictions, Tests of Time Thomas Wellems NIAID, NIH, 2013: Navigating the trypanosome RNA jungle. Elisabetta Ullu Yale School of Medicine, 2012: Pit bull or poodle? How are different breeds and developmental forms of Toxoplasma perfectly suited (or not.) to the challenge de jour. John Boothroyd Stanford School of Medicine 2011: Antigenic variation: it's all about persistence. George Cross The Rockefeller University, 2010: The Major Challenges to Global Health in the Tropics & Beyond— from Insect Vectors of Malaria & of Other Parasitic or Viral Diseases
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  • The Trypanosoma Brucei Subpellicular Microtubule Array Is Organized Into Functionally Discrete

    The Trypanosoma Brucei Subpellicular Microtubule Array Is Organized Into Functionally Discrete

    bioRxiv preprint doi: https://doi.org/10.1101/2020.11.09.375725; this version posted November 9, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete 2 subdomains defined by microtubule associated proteins 3 4 Amy N. Sinclair1,#, Christine T. Huynh1, Thomas E. Sladewski1, Jenna L. Zuromski2, Amanda E. 5 Ruiz2, and Christopher L. de Graffenried1,†,* 6 7 1. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, 8 02912 9 2. Department of Pathology and Laboratory Medicine, Center for International Health Research, 10 Brown University, Providence, RI 02903 11 *To whom correspondence should be addressed. Phone: +1 (401) 863-6148 E-mail: 12 [email protected]. 13 #. ORCID: 0000-0001-6688-6754 14 †. ORCID: 0000-0003-3386-6487 15 16 Short title: Subpellicular array subdomains in T. brucei 17 18 Abbreviations: Flagellum attachment zone (FAZ), microtubule associated protein (MAP), 19 nucleus (N), kinetoplast (K), immunogold electron microscopy (iEM), transmission electron 20 microscopy (TEM), RNA interference (RNAi), mNeonGreen (mNG), maltose binding protein 21 (MBP), total internal reflection fluorescence microscopy (TIRF) 22 23 Keywords: cytoskeleton, microtubules, microtubule associated proteins, subpellicular 24 microtubule array, trypanosomatid, cell morphology bioRxiv preprint doi: https://doi.org/10.1101/2020.11.09.375725; this version posted November 9, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.