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Letter Without Tagline
CH D Press release DONGBAO TO ACQUIRE FERRING’S MALMÖ MANUFACTURING OPERATION Saint Prex, Switzerland and Shanghai, China, Friday 17 November, 2006 – Ferring Pharmaceuticals and Shanghai Dongbao Biopharmaceutical Company announced today the signing of an agreement by which Dongbao Biopharmaceutical will purchase Ferring’s manufacturing operation at Malmö in Sweden. Earlier this year, Ferring informed staff of its plan to cease manufacturing at Malmö by the end of March 2008. However, the acquisition by Dongbao Biopharmaceutical has secured the jobs of around 50 members of staff. The agreement will become effective on 1 January, 2007. “From the very beginning, our aim has been to find a solution which would maintain the Malmö production site,” commented Ferring Pharmaceuticals Chief Operating Officer, Michel Pettigrew. “This agreement is a boost for the local community and has secured the long-term future of the factory for around 50 employees, whose experience will be invaluable to Dongbao Biopharmaceutical.” “We see great potential for the manufacturing centre at Malmö,” added Dr George Li, President of Dongbao Biopharmaceutical. “The site is technically very developed and the current team, who will be an important part of our future business development, offer a lot of knowledge and competencies.” Ends Ferring International Center S.A., Chemin de la Vergognausaz 50, 1162 Saint‐Prex, Switzerland Tel: +41 58 301 00 00, Fax: +41 58 301 00 10, www.ferring.com CH About Ferring: Ferring is a Swiss-based research driven, speciality biopharmaceutical group active in global markets. The company identifies, develops and markets innovative products in the areas of endocrinology, gastroenterology, gynaecology, fertility and urology. -
Triptorelin Pamoate (Subcutaneous Injection) for Prostate Cancer NIHRIO (HSRIC) ID: 20540 NICE ID: 9841
NIHR Innovation Observatory Evidence Briefing: May 2018 Triptorelin pamoate (subcutaneous injection) for prostate cancer NIHRIO (HSRIC) ID: 20540 NICE ID: 9841 LAY SUMMARY Prostate cancer is cancer of the prostate gland (a small organ in a man’s pelvis) and is the second most common cancer in the UK. There are three stages: localised, locally‐advanced and advanced (or metastatic) prostate cancer. The symptoms of prostate cancer may vary depending on the stage of cancer but can include pain, tiredness, problems emptying the bladder and the bowels. About half of men diagnosed with locally‐advanced prostate cancer will see their cancer spread to other body organs (i.e. becoming metastatic). Triptorelin is being developed as an injection under the skin (subcutaneous) for the treatment of locally advanced or metastatic prostate cancer. It is already marketed for this condition but is given by injection deep into the muscles (intramuscular). Triptorelin is an artificial analogue of natural gonadotropin‐releasing hormone that acts to slowly reduce the level of testosterone in the body. The first administration of triptorelin stimulates an increase in testosterone levels but prolonged administration leads to a fall in plasma testosterone or oestradiol to castrate levels which is maintained for as long as the product is administered. Triptorelin as a subcutaneous injection formulation has the potential advantage of improved safety and local tolerability when compared to intramuscular injection formulation. This briefing reflects the evidence available at the time of writing. A version of the briefing was sent to the company for a factual accuracy check. The company was available to provide comment. -
REKOVELLE®, the First Recombinant Follicle Stimulating Hormone Derived
REKOVELLE®, the first recombinant follicle stimulating hormone derived from a human cell line, is now available for Canadian women undergoing IVF and other assisted reproductive technologies REKOVELLE® helps women achieve a more predictable and targeted ovarian response Toronto, Ontario – 29 October 2018 – Ferring Pharmaceuticals announced that REKOVELLE® (follitropin delta injection), the first recombinant FSH for controlled ovarian stimulation derived from a human cell line, is now available in Canada for women undergoing assisted reproductive technologies such as in vitro fertilization (IVF).1 Ovarian response to stimulation varies considerably from woman to woman,2 and unexpected extreme responses have implications on efficacy and safety.3,4 REKOVELLE® is the first gonadotropin to use an evidence-based, personalized dosing algorithm based on a woman’s anti-Müllerian hormone (AMH) level and body weight to achieve a predictable ovarian response.1 “One in six Canadian couples experience infertility and many couples feel anxious about the unknowns of reproductive medicine when they go through IVF for the first time,” says Dr. Al Yuzpe, Reproductive Endocrinologist, Co-Founder and Co-Director of Olive Fertility Centre in Vancouver. “REKOVELLE® provides a more predictable and personalized option considering each woman’s AMH and body weight. We finally have an FSH preparation that is dosed based on scientific evidence, removing the subjective decision of choosing the appropriate dosage of FSH for each woman.” REKOVELLE® was approved by Health Canada on March 22, 2018, and is the first gonadotropin to be granted Innovative Drug status by Health Canada.5 “We are proud to lead the way towards a more innovative and personalized care approach for women undergoing IVF,” said Lee Ferreira, General Manager, Ferring Pharmaceuticals. -
Ferring Pharmaceuticals and Kyowa Kirin Announce Termination the License Agreement and the Supply and Co-Promotion Agreement Of
Ferring Pharmaceuticals and Kyowa Kirin Announce Termination the License Agreement and the Supply and Co-Promotion Agreement of Pharmaceutical Products of Desmopressin Tokyo, February 25, 2020 — Ferring Pharmaceuticals Co., Ltd. (Tokyo Japan; President and CEO: Mark Noggle, “Ferring”) and Kyowa Kirin Co., Ltd., (Tokyo Japan; President and CEO:Masashi Miyamoto, “Kyowa Kirin”) today announced that Kyowa Kirin transfers all marketing authorizations for the products of desmopressin*1 (generic name: Desmopressin Acetate Hydrate) to Ferring effective on and from April 27, 2020, and they terminate the license agreement and the supply and co-promotion agreement about these products of desmopressin and MINIRINMELT®OD Tablet (Desmopressin Acetate Hydrate Orally Disintegrating Tablet) on the same day. The seven products subjected to the termination are listed below. Ferring and Kyowa Kirin have co-promoted for the seven products and Kyowa Kirin has distributed them. Kyowa Kirin terminates to distribute the products on April 26,2020 upon termination of the license agreement. Product Listing Generic name Product name Main indication Supplier Distributor Desmopressin MINIRINMELT®OD Central diabetes Ferring Kyowa Kirin Acetate Tablet Insipidus*2 Pharmaceuticals Co., Ltd. Hydrate (60 ㎍/120 ㎍/240 ㎍) Co., Ltd. DESMOPRESSIN Central diabetes Kyowa Kirin Co., Intranasal 0.01% Insipidus Ltd. Kyowa DESMOPRESSIN・ Spray 2.5 Kyowa DESMOPRESSIN・ Nocturnal enuresis / *3 Spray 10 Kyowa bedwetting DESMOPRESSIN Hemophillia A Injection 4 Kyowa von Willebrand’s disease *1 About Desmopressin Desmopressin is a synthetic analog of antidiuretic hormone (vasopressin), an artificial peptide consisting of 8 amino acids. The drug has a strong antidiuretic action that concentrates the urine and decreases urine output. *2 About central diabetes insipidus Central diabetes insipidus is a disease caused by reduced or absent synthesis or secretion of antidiuretic hormone known as arginine vasopressin (AVP) that causes symptoms such as excessive urination as well as extreme thirst and increased fluid intake. -
Tractocile, Atosiban
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE MEDICINAL PRODUCT Tractocile 6.75 mg/0.9 ml solution for injection 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each vial of 0.9 ml solution contains 6.75 mg atosiban (as acetate). For a full list of excipients, see section 6.1. 3. PHARMACEUTICAL FORM Solution for injection (injection). Clear, colourless solution without particles. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Tractocile is indicated to delay imminent pre-term birth in pregnant adult women with: regular uterine contractions of at least 30 seconds duration at a rate of 4 per 30 minutes a cervical dilation of 1 to 3 cm (0-3 for nulliparas) and effacement of 50% a gestational age from 24 until 33 completed weeks a normal foetal heart rate 4.2 Posology and method of administration Posology Treatment with Tractocile should be initiated and maintained by a physician experienced in the treatment of pre-term labour. Tractocile is administered intravenously in three successive stages: an initial bolus dose (6.75 mg), performed with Tractocile 6.75 mg/0.9 ml solution for injection, immediately followed by a continuous high dose infusion (loading infusion 300 micrograms/min) of Tractocile 37.5 mg/5 ml concentrate for solution for infusion during three hours, followed by a lower dose of Tractocile 37.5 mg/5 ml concentrate for solution for infusion (subsequent infusion 100 micrograms/min) up to 45 hours. The duration of the treatment should not exceed 48 hours. The total dose given during a full course of Tractocile therapy should preferably not exceed 330.75 mg of atosiban. -
Actual Place of Diuretics in Hypertension Treatment
Mini Review J Cardiol & Cardiovasc Ther Volume 3 Issue 4 - March 2017 Copyright © All rights are reserved by Farouk Abcha DOI: 10.19080/JOCCT.2017.03.555616 Actual Place of Diuretics in Hypertension Treatment Farouk Abcha, Marouane Boukhris*, Zied Ibn Elhadj, Lobna Laroussi, Faouzi Addad, Afef Ben Halima and Salem Kachboura Cardiology Department of Abderrahmen Mami Hospital, University of Tunis El Manar, Tunisia Submission: February 03, 2017; Published: March 07, 2017 *Corresponding author: Marouane Boukhris, Cardiology Department of Abderrahmen Mami Hospital, Ariana, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia, Tel: ; Email: Abstract Diuretics represent a large and heterogeneous class of drugs, differing from each other by structure, site and mechanism of action. Diuretics are widely used, and have several indications in different cardiovascular disorders, particularly in hypertension and heart failure. Despite the large number of available anti-hypertensive drugs, diuretics remained a cornerstone of hypertension treatment. In the current editorial, we assessed the actual place of different diuretics in the hypertension guidelines focusing on the concept of tailored approach in prescribing them for hypertensive patients. Keywords: Diuretics; Hypertension; Hydrochlorothiazide; Indapamide; Guidelines Introduction Diuretics represent a large and heterogeneous class of drugs, differing from each other by structure, site and mechanism of action. Diuretics are widely used, and have several indications in different cardiovascular disorders, particularly in hypertension and heart failure. Despite the large number of available anti-hypertensive drugs, diuretics remained a cornerstone of hypertension treatment [1]. Indeed, they are the second most commonly prescribed class of antihypertensive medication. For instance, 12% of US adults were prescribed a diuretic, and the relative increase in prescriptions from 1999 through 2012 was 1.4 [2]. -
Approach to Managing Patients with Sulfa Allergy Use of Antibiotic and Nonantibiotic Sulfonamides
CME Approach to managing patients with sulfa allergy Use of antibiotic and nonantibiotic sulfonamides David Ponka, MD, CCFP(EM) ABSTRACT OBJECTIVE To present an approach to use of sulfonamide-based (sulfa) medications for patients with sulfa allergy and to explore whether sulfa medications are contraindicated for patients who require them but are allergic to them. SOURCES OF INFORMATION A search of current pharmacology textbooks and of MEDLINE from 1966 to the present using the MeSH key words “sulfonamide” and “drug sensitivity” revealed review articles, case reports, one observational study (level II evidence), and reports of consensus opinion (level III evidence). MAIN MESSAGE Cross-reactivity between sulfa antibiotics and nonantibiotics is rare, but on occasion it can affect the pharmacologic and clinical management of patients with sulfa allergy. CONCLUSION How a physician approaches using sulfa medications for patients with sulfa allergy depends on the certainty and severity of the initial allergy, on whether alternatives are available, and on whether the contemplated agent belongs to the same category of sulfa medications (ie, antibiotic or nonantibiotic) as the initial offending agent. RÉSUMÉ OBJECTIF Proposer une façon d’utiliser les médicaments à base de sulfamides (sulfas) chez les patients allergiques aux sulfas et vérifier si ces médicaments sont contre-indiqués pour ces patients. SOURCES DE L’INFORMATION Une consultation des récents ouvrages de pharmacologie et de MEDLINE entre 1966 et aujourd’hui à l’aide des mots clés MeSH «sulfonamide» et «drug sensitivity» a permis de repérer plusieurs articles de revue et études de cas, une étude d’observation et des rapports d’opinion consensuelles (preuves de niveau III). -
Estonian Statistics on Medicines 2016 1/41
Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole -
Diuretics for Hypertension
The Rx Files: Q&A Summary March 1998, LDR DIURETICS IN THE TREATMENT OF HYPERTENSION: CURRENT STATUS 1. When are thiazide diuretics considered first line antihypertensives? Antihypertensive therapy should be individualized by choosing agents that have favorable effects on comorbid conditions. The recent JNC VI report1 recommends thiazides (or â Blockers) as first line agents in the treatment of uncomplicated hypertension except where contraindicated, not tolerated, or concurrent medical conditions favor use of alternate agents (see Appendix 1).1 Thiazide diuretics and â Blockers are the only antihypertensives that have been well documented in long-term controlled trials to reduce cardiovascular morbidity and mortality, particularly MI and stroke.2 Current large-scale trials are underway to determine if other classes of antihypertensives have similar benefits. Thiazides are particularly effective in elderly patients with isolated systolic hypertension.1 They also have favorable effects in patients at risk of osteoporosis. When not used for initial monotherapy, addition of a low dose diuretic as the second agent is recommended unless contraindicated.1 2. Are low dose thiazides as effective in treating hypertension as higher doses? Doses as low as 12.5-25mg of hydrochlorothiazide (HCT), given once daily, have been as effective in lowering blood pressure as higher doses.3 In fact, doses above 25mg have little added benefit but greater incidence of adverse effects.3,7 A dose of 6.25mg HCT can often significantly augment the response of other antihypertensives when used in combination. 3. What about the adverse metabolic effects of thiazides? In doses of 25mg or less, incidence of hypokalemia is <5%, and few patients will actually require potassium supplementation or addition of a K+ sparing diuretic. -
PHRP March 2015
March 2015; Vol. 25(2):e2521518 doi: http://dx.doi.org/10.17061/phrp2521518 www.phrp.com.au Research Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study Danijela Gnjidica,b,i, Sallie-Anne Pearsona,c, Sarah N Hilmerb,d, Jim Basilakise, Andrea L Schaffera, Fiona M Blythb,f,g and Emily Banksg,h, on behalf of the High Risk Prescribing Investigators a Faculty of Pharmacy, University of Sydney, NSW, Australia b Sydney Medical School, University of Sydney, NSW, Australia c Sydney School of Public Health, University of Sydney, NSW, Australia d Royal North Shore Hospital and Kolling Institute of Medical Research, Sydney, NSW, Australia e School of Computing, Engineering and Mathematics, University of Western Sydney, NSW, Australia f Centre for Education and Research on Ageing (CERA), Concord Hospital, Sydney, NSW, Australia g The Sax Institute, Sydney, NSW, Australia h National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT i Corresponding author: [email protected] Article history Abstract Publication date: March 2015 Background: Increasingly, automated methods are being used to code free- Citation: Gnjidic D, Pearson S, Hilmer S, text medication data, but evidence on the validity of these methods is limited. Basilakis J, Schaffer AL, Blyth FM, Banks E. To examine the accuracy of automated coding of previously keyed Manual versus automated coding of free-text Aim: in free-text medication data compared with manual coding of original self-reported medication data in the 45 and Up Study: a validation study. Public Health handwritten free-text responses (the ‘gold standard’). -
Efficacy of Indapamide 1.5 Mg, Sustained Release, in the Lowering of Systolic Blood Pressure
Journal of Human Hypertension (2004) 18, S9–S14 & 2004 Nature Publishing Group All rights reserved 0950-9240/04 $30.00 www.nature.com/jhh ORIGINAL ARTICLE Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure GM London Service de ne´phrologie, Hoˆpital Manhe`s, Ste Genevie`ve des Bois, France The relationship between the increase in blood pressure indapamide SR resulted in a better or equivalent control and the incidence of cardiovascular disease is well of SBP than treatment with a standard dose of a true recognized today. Studies have shown that more thiazide diuretic (hydrochlorothiazide), a calcium chan- attention should be paid to systolic blood pressure nel blocker (amlodipine), and an angiotensin-converting (SBP) in relation to cardiovascular risk and that enzyme inhibitor (enalapril). No therapeutic escape was therapeutic interventions should preferably focus on observed. All treatments showed good acceptability reducing SBP. The antihypertensive efficacy of indapa- with no unexpected adverse event. In conclusion, mide 1.5 mg sustained release (indapamide SR), a low- indapamide SR is very effective in lowering SBP—a dose thiazide-type diuretic, was assessed on SBP. Three major independent cardiovascular risk factor—notably randomized, double-blind, controlled studies were con- in hypertensive high-risk patients with LVH, the elderly ducted with indapamide SR, over a period of 3 to 12 and diabetics, when compared to major antihyperten- months. Elderly patients or patients with target-organ sive treatments. This SBP-lowering effect is maintained damage, hypertension and left ventricular hypertrophy over the long term. (LVH) (LIVE study) or with type II diabetes with micro- Journal of Human Hypertension (2004) 18, S9–S14. -
INDAPAMIDE 2.5MG TABLETS Indapamide Read All of This Leaflet Carefully Before You Start Taking This Medicine Because It Contains Important Information for You
287.5 x 207 mm - side1 PACKAGE LEAFLET: INFORMATION FOR THE USER INDAPAMIDE 2.5MG TABLETS Indapamide Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again • If you have any further questions, ask your doctor or pharmacist • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4 • Diuretics or “water tablets”, such as bumetanide, furosemide, thiazides and What is in this leaflet xipamide 1. What Indapamide Tablets are and what they are used for • Diuretics or “water tablets” such as amiloride, spironolactone and triamterene 2. What you need to know before you take Indapamide Tablets which increase the flow of urine without excessive loss of potassium 3. How to take Indapamide Tablets • Lithium, an antidepressant due to the risk of increased level of lithium in the blood 4. Possible side effects • Quinidine or cardioglycosides, such as digoxin, disopyramide, amiodarone 5. How to store Indapamide Tablets and sotalol, ibutilide, dofetilite, digitalis which are used to treat abnormal 6. Contents of the pack and other information heart beat • Lidocaine, flecainide and mexiletine (to treat irregular heart beat) • Intravenous erythromycin, an antibiotic 1. WHAT INDAPAMIDE TABLETS ARE AND WHAT THEY • Pentamidine (used in the treatment of protozoal infections) • Prazosin, which is used to treat high blood pressure ARE USED FOR • Antiepileptics such as oxcarbazepine The name of your medicine is Indapamide 2.5mg Tablets.