US010111822B2 (12 ) United States Patent ( 10) Patent No. : US 10 , 111, 822 B2 Shibuya et al. (45 ) Date of Patent: Oct. 30 , 2018 (54 ) EXTERNAL DERMAL COMPOSITION FOR A61Q 19 /02 (2013 .01 ) ; A61Q 19 / 08 ANTI - AGEING AND METHOD FOR ( 2013 .01 ) ; A61K 2800 /5922 (2013 . 01) ; A61K PRODUCING THE SAME 2800/ 805 ( 2013 .01 ) (58 ) Field of Classification Search (71 ) Applicant: Hayashibara Co ., Ltd ., Okayama ( JP ) None ( 72 ) Inventors: Takashi Shibuya , Okayama ( JP ) ; See application file for complete search history . Akiko Miyake , Okayama ( JP ) ; Tatsuya Ishihara , Okayama ( JP ); Masaki Miyake, Okayama (JP ); Hitomi Wake , (56 ) References Cited Okayama ( JP ) U . S . PATENT DOCUMENTS (73 ) Assignee : HAYASHIBARA CO . , LTD ., Okayama 5 ,084 , 563 A * 1 /1992 Sakai ...... A61K 8 /67 (JP ) 424 /60 5 , 137 , 723 A 8 / 1992 Yamamoto et al . ( * ) Notice : Subject to any disclaimer, the term of this 5 ,882 ,658 A 3 / 1999 Simon et al. patent is extended or adjusted under 35 6 ,437 ,002 B18 /2002 Ito et al. U . S .C . 154 (b ) by 0 days . 2001/ 0051711 Al 12/ 2001 Yamasaki et al . 2003/ 0130331 A1* 7/ 2003 Donsbach ...... CO7D 235 / 20 514 /394 (21 ) Appl. No. : 14 /655 , 068 2007 /0066565 A1 3 /2007 Mukai et al . 2007 /0248633 Al 10 /2007 Baldo ( 22 ) PCT Filed : Dec. 26 , 2013 2009/ 0041848 AL 2 /2009 Ain et al. ( 86 ) PCT No. : PCT/ JP2013/ 084817 2011/ 0091726 A1 4 / 2011 Shibuya et al . $ 371 ( c ) ( 1 ), FOREIGN PATENT DOCUMENTS (2 ) Date : Jun . 24 , 2015 CA 2828516 Al 9 / 2012 CN 1300215 A 6 / 2001 ( 87 ) PCT Pub . No. : W02014 /104171 FR 2924335 A1 6 / 2009 59 - 10505 A 1 / 1984 PCT Pub. Date : Jul. 3 , 2014 61 - 152613 A 7 / 1986 3 - 135992 A 6 / 1991 (65 ) Prior Publication Data 3 - 139288 A 6 / 1991 US 2015 /0342854 A1 Dec . 3 , 2015 (Continued ) (30 ) Foreign Application Priority Data OTHER PUBLICATIONS Dec . 27 , 2012 (JP ) ...... 2012 - 285949 JP 06 - 220081; machine translation ( 1994 ) ). * Dec . 27 , 2012 ( JP ) ...... 2012 - 285958 Oct. 11 , 2013 (WO ) ...... PCT /JP2013 /077768 (Continued ) (51 ) Int. CI. A61K 8 /67 ( 2006 .01 ) Primary Examiner — Jake M Vu A610 19 /02 ( 2006 .01 ) (74 ) Attorney , Agent, or Firm — Browdy and Neimark , A61K 8 /92 ( 2006 .01 ) PLLC A61K 8 / 98 ( 2006 .01 ) A61K 8 / 64 ( 2006 . 01 ) A61K 8 / 49 ( 2006 .01 ) (57 ) ABSTRACT A61K 8 /34 ( 2006 .01 ) A610 19 /08 ( 2006 . 01 ) The present invention has an object to provide an external A61K 8 /97 ( 2017 .01 ) dermal composition for anti -ageing , which prevents or A61K 31/ 7048 ( 2006 . 01 ) improves apparent skin problems such as wrinkles , fine A610 19 / 00 ( 2006 .01 ) wrinkles , blemishes , and saggings caused by increasing age AIK 8 /60 ( 2006 . 01 ) A61K 8 /9789 ( 2017 . 01 ) or ageing ; and maintains or improves the barrier function A61K 8 /9771 ( 2017 .01 ) and the hyaluronic acid production in the skin . The object is (52 ) U . S . CI. solved by providing an external dermal composition for CPC ...... A61K 8 /676 (2013 .01 ) ; A61K 8 /345 anti- ageing, which contains an aqueous medium as a base ( 2013 .01 ) ; A61K 8 /498 ( 2013 .01 ) ; A61K 8 / 4926 ( 2013 .01 ) ; A61K 8 /4953 ( 2013 .01 ) ; material and one or more ingredients selected from L - ascor A61K 8 /602 ( 2013 . 01 ) ; A61K 8 /64 ( 2013 . 01) ; bic acid , derivatives thereof, and their salts as an effective A61K 8 /922 ( 2013 . 01 ) ; A61K 8 /97 ( 2013 . 01 ) ; ingredient( s ) . A61K 8 / 9771 ( 2017 .08 ) ; A61K 8 /9789 ( 2017 . 08 ) ; A61K 8 /988 ( 2013 .01 ) ; A6IK 31/ 7048 ( 2013 . 01 ) ; A61Q 19/ 00 ( 2013. 01 ) ; 10 Claims, 3 Drawing Sheets US 10 ,111 ,822 B2 Page 2
References Cited JP 2010 - 195686 A 9 /2010 (56 ) JP 2012 -67013 A 4 / 2012 WO 99 /59580 A1 11 / 1999 FOREIGN PATENT DOCUMENTS WO 20110361 A1 2 / 2002 wo 2005034938 A1 4 / 2005 05 - 339123 A 12 / 1993 WO 2007011066 A1 1 / 2007 6220081 8 / 1994 Wo 2007094312 A1 8 / 2007 6 - 247956 A 9 / 1994 WO 2012033218 A1 3 / 2012 06 - 263790 A 9 / 1994 WO 2012121297 AL 9 /2012 63 - 104971 A 5 / 1998 2002 -003330 A 1 / 2002 2002 - 88095 A 3 /2002 OTHER PUBLICATIONS 2004 - 331524 A 11 / 2004 2005 - 95148 A 4 / 2005 Scifinder ( 20126 ) . * 2006 - 063060 A 3 / 2006 Schnider et al. , Effects of age and diabetes mellitus on the solubility 2006 - 063067 A 3 / 2006 and nonenzymatic glucosylation of human skin collagen , J. Clin . 2007291102 A 11 / 2007 2008 - 169196 A 7 / 2008 Invest. , 67: 1630 - 1635 ( 1981) . 2008 - 255020 A 10 / 2008 Shin -Keshouhin -Handbook , pp . 518 - 539 , Nikko Chemicals Co . , 2008 -260721 A 10 / 2008 Ltd .; published by Chou Printing Co . Ltd . (Oct . 30 , 2006 ) with 2009 - 040690 A 2 / 2009 English language translation of excerpt. WO2007011066 A1 2 /2009 2009 - 249306 A 10 /2009 * cited by examiner U . S . Patent Oct. 30 , 2018 Sheet 1 of 3 US 10 , 111 ,822 B2
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FIG . 5 US 10 , 111 , 822 B2 EXTERNAL DERMAL COMPOSITION FOR turnover rate is fast, the level of melanin pigment, produced ANTI -AGEING AND METHOD FOR by melanocytes, for absorbing ultraviolet rays in the skin PRODUCING THE SAME will increase ; and this accelerates cosmetically -unfavorable melanin pigmentation by ultraviolet rays . TECHNICAL FIELD 5 It is said that, as a recent finding, in vivo glycation in the skin ( simply called “ glycation ” , hereinafter ) relates to the The present invention relates to an external dermal com delaying of skin turnover rate and associates with skin position for anti -ageing and a method for producing the ageing . Glycation may be also called Maillard reaction ( or same, more particularly , to an external dermal composition browning reaction ) and meant as a process ranging from the for anti -ageing that prevents or improves wrinkles , fine 10 bindingbin of reducing saccharides such as glucose and fructose wrinkles , blemishes, or saggings in the skin , as well as to a with the epidermis ( collagen ) or the keratinous layer (kera basic skin care containing the external dermal composition tin ) to the formation of substances called advanced glycation and a method for producing these compositions. end products , i. e . AGEs . It is recognized that AGEs deposit on skin tissues and bind to a receptor for AGEs called BACKGROUND ART RAGE ; induce an inflammatory change in the skin or other Desire to be youthful to the end of time is a humans' tissues ; form disorganized linkages in collagen intra - and common and universal desire , however, all humankind have inter- molecularly during the formation of AGEs to induce experienced for long to have appeared wrinkles , fine physical or physiological changes (deteriorations ) on colla wrinkles , blemishes , or saggings in the skin as they become 20 gen ; and cause skin ageing such as wrinkles, rough skin , older. Ageing also causes skin ageing , and the appearance of saggings , or the reduction of skin firmness . It is also said that apparent changes such as wrinkles, fine wrinkles , blemishes , collagen , wherein disorganized linkages are formed intra - or or saggings in the skin has been recognized to be so called inter- molecularly through glycation , would lose elasticity natural providence as an unavoidable thing . and become to be hardly decomposed by in vivo proteases, Recently , however, causatives or mechanisms of apparent 25 resulting in a delaying of skin turnover rate ( see Non Patent changes such as wrinkles , blemishes, or saggings in the skin Literature 1 ) . with ageing are gradually being revealed as the progress of As described above , since the delaying of skin turnover researches on the structure and the metabolic mechanism of rate with ageing is said to induce wrinkles, saggings , or human skin . As well known , the skin is constructed by the rough skin , if any means for making up for a delayed outer thin epidermis ( epithelium tissue) and the lower lay - 30 turnover rate with ageing would be avairable , even though ered thick dermis ( connective tissue ) ; and the epidermis , as it is really hard to catch up the delayed turnover rate of the the outermost layer , protects living bodies from the outside skin of a so called pre - ageing generation , including those in world and prevents the leakage of internal moisture and the around 30 - to 50 - year -old age group who start worrying nutrients to the outside of the bodies. While , the dermis is a aboutthe above - identified skin conditions, to the level of the connective tissue having the structure , where fibroblasts , 35 twenties as the normal skin turnover rate , it would possibly collagens, elastins, proteoglycans and the like mainly spread effectively improve such wrinkles , saggings, or rough skin . complexly and three -dimensionally , which has roles for From this aspect, turnover rate may possibly be improved by imparting strength , extensibility , and elasticity to the skin ; either accelerating the turnover rate through the promotion however , the moisture - retaining ability of the cuticle in the of at least one step among sequential series of proliferation , skin surface will be lost as the decrease of sebum and 40 migration , differentiation , and desquamation ; or inhibiting moisture contents in the skin with ageing and it may become glycation recognized as to induce the delaying of turnover to easily induce fine wrinkles and rough skin due to dryness r ate ; however, any actual means for solving it has not yet of the skin or the like . been provided . Human epidermis , which is constructed by “ keratinous W hen fibroblasts and hyaluronic acid in the dermis may layer” ( stratum corneum ), " granular layer” , “ stratum spino - 45 be reduced with ageing or the breakage of collagen and the sum ” , and “ stratum germinativum ” located in this order deterioration of elastin may be induced with ageing , from the outersurface , is finally cast off as a result of wrinkles are allegedly formed or the elasticity of the skin are keratinocyte generated in the stratum germinativum , and said to be lowered to cause dull or rough skin . There is also sequentially moved to the outer surface . In particular , kera - a finding that a non -smooth egestion of melanin excreted tinocyte is proliferated in the stratum germinativum located 50 from melanocytes to epidermal cells may be causative for st of the epidermis , differentiated , moved pigmentation ( blemishes ) and dullness of the skin . upward , finally turned into the keratinous layer located in the Based on these research results and findings, at present, outermost of the keratinous layer ( stratum corneum ) , and there can be seen proposals ( see , for example , Patent Lit then desquamated as scurf. Such serial process of prolifera - eratures 1 to 7 ) so called external dermal agents for anti tion , movement, differentiation , and desquamation is called 55 ageing that theoretically prevent or improve the apparent turnover , where the skin homeostasis is retained by newly changes such as wrinkles , fine wrinkles , blemishes , saggings rebirthing keratinocyte at a constant cycle that may induce in the skin , or the like in the skin with ageing , in terms of wrinkles , saggings , and rough skin by delaying the turnover scientific point of view , whereby humans are getting nearer rate of the skin with ageing . Though the turnover rate of the to the realization of the desire to keep youthfulness to the skin varies depending on the sites of the body , it is said that 60 end of time step by step . Currently -proposed external dermal healthy teenagers have a turnover rate of about 20 days ; agents for anti - ageing , however, have only pursued and twenties , about 28 days ; thirties , about 40 days ; forties , realized quite partial possibilities from among many possi about 55 days as roughly two times of that of twenties ; and bilities. Accordingly , there is still desired a providing of a fifties, about 75 days . By the way , even if the turnover rate novel external dermal agent for anti -ageing from different of the skin becomes fast or slow , it should not be preferable , 65 angles , including distinctly differentmechanisms of exerting while the normal skin turnover rate is recognized to be 28 anti - ageing effects from currently - proposed external dermal days as that of twenties . The reason is that, when the agents for anti- ageing , which have been merely realized as US 10 , 111 , 822 B2 a result of pursuing only a part of various possibilities , L - ascorbic acid or derivatives thereof can be in a salt form . conveniences , and production feasibilities. L - Ascorbic acid is released from such salts of L - ascorbic acid in an aqueous medium , while salts of L -ascorbic acid PRIOR ART LITERATURES derivatives release L - ascorbic acid derivatives in an aqueous medium , whereby the released L - ascorbic acid derivatives Patent Literatures further release L - ascorbic acid via the action of an enzyme present in living human bodies when applied to the skin . Patent Literature 1 : Japanese Republication No. WO2007 / Accordingly , in addition to L - ascorbic acid , one or more 011066 members selected from derivatives and salts of L - ascorbic Patent Literature 2 : Japanese Patent KokaiNo . 2007 - 291102 10 acid are used in the external dermal composition and the PatentLiterature 3 : Japanese Patent Kokai No. 2008 - 169196 basic skin care of the present invention as an effective Patent Literature 4 : Japanese Patent Kokai No . 2008 - 255020 ingredient( s ) having an anti -ageing effect of preventing or Patent Literature 5 : Japanese Patent Kokai No . 2008 -260721 improving wrinkles , fine wrinkles , blemishes, saggings, etc ., Patent Literature 6 : Japanese Patent Kokai No . 2009 -040690 appeared in the skin with ageing . Patent Literature 7 : Japanese Patent Kokai No. 2009 - 249306 15 Glycosyl- , acyl- , or phosphoryl- derivatives of L -ascorbic acid are preferably used as L - ascorbic acid derivatives; Non - Patent Literature among which 2 - 0 - C - D - glucosyl- L - ascorbic acid or sodium salt thereof as a glycosyl derivative of L - ascorbic acid is Non - Patent Literature 1 : The Journal of Clinical Investiga - more preferably used because it is quite stable and exerts a tion , Schneider , S . L ., et al. , Vol. 67 , pp . 1630 - 1635 , 1981 20 remarkable anti -ageing effect when incorporated in the external dermal composition or the basic skin cares of the DISCLOSURE OF INVENTION present invention . Such 2 - 0 - C - D -glucosyl - L -ascorbic acid and sodium salt Object of the Invention thereof are preferably used in a crystalline form . Examples 25 of suitably used crystalline 2 - 0 - a - D - glucosyl- L -ascorbic The present invention, which was made based on the acid include , for example , a particulate composition con current state of the above prior art , aims to provide a novel taining anhydrous crystalline 2 - 0 - a - D - glucosyl - L - ascorbic external dermal composition for anti -ageing and a basic skin acid as disclosed in Japanese Patent Kokai Nos . 135992 /91 , care which contains the same directed to prevent or improve 2012 -67013 , etc . , applied by the same applicant as the skin changes such as wrinkles, fine wrinkles, blemishes , 30 present invention . saggings in the skin that are inducible with ageing ; and to While , examples of crystals of sodium salt of 2 - 0 - C - D provide a method for producing the same. glucosyl -L - ascorbic acid include a hydrous crystal thereof having diffraction peaks at diffraction angles ( 20 ) of 6 .8° , Means to Attain the Object 8 . 2° , 14 . 3°, 17 .8° , and 18 .4° , or an anhydrous crystal thereof 35 having diffraction peaks at diffraction angles ( 20 ) of 8 . 0°, The present inventors have eagerly researched and made 9 .0° , 16 . 4° , 17 .9° , and 20 .8° . These hydrous and anhydrous efforts to solve the above objects . As a result, they found that crystalline sodium salts of 2 - 0 - C - D - glucosyl- L -ascorbic L - ascorbic acid , derivatives thereof, and their salts have acid , which are novel crystals constructed by the present remarkable anti- ageing effects , i. e ., effects of improving the inventors , can be advantageously , particularly , suitably used skin turnover, maintaining or improving the barrier function 40 in the present invention as the effective ingredient ( s ) of the of the skin , and maintaining or improving the production of present invention because they are easily highly -purified by hyaluronic acid in the skin ; resulting in preventing or crystallization and easily confirmed their properties , effec improving wrinkles , fine wrinkles , blemishes , saggings , etc ., tiveness , and safeness , as well as being advantageously , in the skin that are appeared with ageing ; and found that an relatively easily prepared into high -purity preparations for external dermal composition that exerts the above effects 45 use as the effective ingredients of the present invention . can be easily produced by a production method containing For reference , 2 - 0 - a - D - glucosyl- L -ascorbic acid as a a step of mixing the above L - ascorbic acid , derivatives glycosyl derivative of L - ascorbic acid exhibits a relatively thereof , or their salts with an aqueous medium used as a base strong acidity in an aqueous medium and it usually essen material. Thus, they accomplished the present invention . tially requires a step of neutralizing it with an appropriate The present invention solves the above objects by pro - 50 alkali to give a pH of around 5 to 9 when incorporated into viding an external dermal composition for anti -ageing , external dermal agents or cosmetics to be applied to the skin . which contains an aqueous medium as a base material and The above -mentioned hydrous and anhydrous crystalline one or more members selected from L -ascorbic acid , sodium salts of 2 - 0 -a - D - glucosyl- L -ascorbic acid , how L -ascorbic acid derivatives , and their salts as an effective ever, exhibit alkalinity in an aqueousmedium , and therefore, ingredient( s ) ; and a basic skin care containing the external 55 the combination use of 2 - 0 - C - D - glucosyl- L - ascorbic acid dermal composition . The present invention also solves the and its crystalline sodium salt can produce external dermal above objects by providing a method for producing an compositions or basic skin cares having a pH within the external dermal composition for anti -ageing or a basic skin desired pH range without neutralizing 2 - O - a - D - glucosyl- L care, which contains a step of mixing one or more members ascorbic acid with an alkali as a quite advantageous merit by selected from L -ascorbic acid , L -ascorbic acid derivatives , 60 appropriately controlling the composition ratio of them . and their salts with an aqueous medium as a base material. When used in combination , 2 - 0 - a - D - glucosyl- L - ascorbic The effective ingredient( s ) for the external dermal com - acid and hydrous and / or anhydrous crystalline sodium salt position and the basic skin care of the present invention thereof can be conveniently incorporated into a composition is / are basically L -ascorbic acid . Since L - ascorbic acid has for use in an appropriate ratio to give a predetermined reducibility and easily loses its physiological activity due to 65 desired pH range after being mixed with an aqueous its high unstableness , derivatives of L -ascorbic acid are medium . In the case of an external dermal composition or a more preferably used than L -ascobic acid per se . Such basic skin care such as a face wash , which is allowed to have US 10 , 111 , 822 B2 an alkaline pH , it goes without saying that hydrous and /or membrane , which is composed of proteins such as involu anhydrous crystals of sodium salt of 2 - 0 - a - D - glucosyl- L crin , called as a cornified envelope (CE ) that protects the ascorbic acid can be used alone as an effective ingredient inside of corneocytes . The above - identified CE and TJ play without being used in combination with 2 - 0 - a - D - glucosyl important roles in skin barrier function . When the skin L -ascorbic acid . 5 barrier function lowers , collagen , elastin , hyaluronan Although the external dermal composition of the present (hyaruronic acid ) , etc . , which exist in the dermis , will be damaged by the exposure of ultraviolet rays , particularly , invention can be used alone as an external dermal compo ultraviolet A ( long - wave ) that reaches up to the dermis ; also sition for anti -ageing , it can be preferably used as basic skin such lowering may be known to induce skin dryness and cares after the addition of commonly used appropriate excessive sebum secretion to induce adults acne or may cosmetic ingredients . For example , the external dermal 10 induce any disorder of turnover. With ageing , skin barrier composition for anti- ageing of the present invention can be function will lower, resulting in inducing wrinkles, fine made into a cosmetic lotion after the addition of ethanol and wrinkles , blemishes, saggings , etc . , in the skin . a humectant , and the resulting cosmetic lotion can be Further , the term “ maintaining or improving the produc incorporated with one or more astringents , cuticles softener, tion of hyaluronic acid ” as referred to in the present inven emollients, and surfactants . Such cosmetic lotion can be 15 tion means an enhancement of the production level of arbitrarily incorporated with one or more flavors , pigments , hyaluronic acid from hyaluronic acid - producing cells in the antiseptics , ultraviolet - ray - absorbing agents , sequestering skin , resulting in maintaining and improving skin barrier agents , and buffers . function and then imparting an anti - ageing effect. The external dermal composition for anti - ageing of the Also , the term " inhibiting glycation ” as referred to in the present invention can be made into a face -wash by the 20 present invention means to inhibit a reaction ( also called addition of an alkaline salt of a higher fatty acid ( a soap ) , and Maillard reaction or browning reaction ) , where reducing needless to say that it can be incorporated with one or more saccharides such as glucose , fructose , and the like non flavors , pigments , antioxidants , and sequestering agents . enzymatically bind to the dermis (collagen ) or the keratinous Needless to add , glycerin , ethanol, sugar, polyalcohols , or layer (keratin ) to form substances called advanced glycation antiseptics can be further added to such a face -wash . 25 end products ( AGES ). AGEs are known to induce skin The external dermal composition for anti - ageing of the ageing such as wrinkles , rough skin , dullness , and reduction present invention can be made into a serum by the addition of firmness . of a humectant and emollient , and such a serum can be incorporated with one or more flavors , ultraviolet -ray - ab Effect of the Invention sorbing agents , skin - whiteners , anti -inflammatories , antisep - 30 tics, and bactericides . Also , the external dermal composition According to the external dermal composition for anti for anti -ageing of the present invention can be made into a ageing and the basic skin cares containing the same of the milky lotion by the addition of an appropriate oily ingredient present invention , changes in the skin with ageing such as and surfactant, and such a milky lotion can be incorporated wrinkles , fine wrinkles , blemishes , and saggings in the skin with one or more appropriate humectants, emollients , blood 35 can be effectively prevented or improved as advantageous circulation accelerators , and high molecular substances. merits . Particularly, in the case of using 2 - 0 - a - D - glucosyl Further the external dermal composition for anti- ageing of L -ascorbic acid or sodium salt thereof as a glycosyl deriva the present invention can be made into a cream by the tive of L -ascorbic acid as an effective ingredient, there can addition of an appropriate oily ingredient and surfactant, and be exerted an advantageous merit that the effective ingredi the cream can be appropriately incorporated with sperma - 40 ents are highly stably retained in the resulting external ceti , cetanol, lanolin , liquid paraffin , petrolatum , glycerin , or d ermal compositions and basic skin cares to exert a distinct squalane . anti -ageing effect when applied to the skin . In the case of The term “ skin -turnover - improving ” as referred to in the using 2 - 0 - C - D - glucosyl- L - ascorbic acid and / or sodium salt present invention means to maintain a series of steps ( turn - thereof in a crystalline form , they can be made into a over ) of proliferation , migration , differentiation , and desqua - 45 distinctly high purity 2 - 0 - a - D - glucosyl- L -ascorbic acid mation of epidermal cells (keratinocytes ) as the origin of the and / or sodium salt thereof by excluding impurities contained skin composed of “ keratinous layer ( stratum corneum ) ”, their materials as much as possible for use as effective " layer of corneocytes ” , “ stratum spinosum ” , and “ basal ingredients for the external dermal compositions and the layer” at its healthy conditions . More concretely, it means to basic skin cares , while ensuring a distinctly high safeness improve the reduction of turnover rate of the skin with 50 and applicability to the skin with safeness as advantageous ageing . merits . When 2 - 0 - a - D - glucosyl- L -ascorbic acid and The term “ maintaining or improving the barrier function sodium salt thereof are used in combination for producing in the skin ” as referred to in the present invention means that the external dermal composition for anti -ageing and the maintaining or improving the function of a keratinous layer basic skin cares containing the same according to the present called as a secondary barrier, which corresponds to the 55 invention , 2 - 0 - a - D - glucosyl - L -ascorbic acid exhibits a function of a sebum barrier called as a primary barrier; the relatively strong acidity but the sodium salt exhibits an function of protecting either the invasion of foreign sub alkalinity when they are mixed with an aqueous medium ; stances into living bodies from the outside of the bodies or there can be exerted an advantageous merit that an external the release of an excessive amount of moisture from the dermal composition and the basic skin cares with a pH internal of the bodies to the external thereof, and the 60 within a desired pH range without neutralizing 2 - 0 - a - D maintenance or the improvement of the function of separat- glucosyl - L - ascorbic acid with any alkali by appropriately ing the inside of living bodies from the outside thereof by controlling their ratio . adherens junction structure called tight junction ( TJ) that exists in a granular layer of epidermis adjacent to a kerati BRIEF DESCRIPTION OF DRAWINGS nous layer. For reference , such a keratinous layer is a layer 65 composed of corneocytes piled up in multiple layers , FIG . 1 A microscopic photograph of a crystalline sodium wherein in the outermost layer thereof there exists a tight salt of ascorbic acid 2 - glucoside ( hydrous crystal ) . US 10 , 111, 822 B2 FIG . 2 A microscopic photograph of a crystalline sodium composition of the present invention can be listed as gly salt of ascorbic acid 2 - glucoside ( anhydrous crystal) . cosyl derivatives, acyl derivatives , and phosphoryl deriva FIG . 3 A figure that compares an FT- IR spectrum for an tives of L -ascorbic acid . anhydrous crystalline sodium salt of ascorbic acid 2 - gluco - Examples of the glycosyl derivatives of L -ascorbic acid side ( A ) with the one for an anhydrous crystalline ascorbic 5 include the one , wherein a glycosyl group binds to the C - 2 acid 2 - glucoside as a control ( B ) . position of L - ascorbic acid , suitably used because of its high FIG . 4 A figure that compares, with each other , powder stableness . Examples of such derivatives can be listed as 2 - 0 - a -glycosyl - L -ascorbic acid (ascorbic acid 2 - glucoside) , X - ray diffraction figures for a hydrous crystalline sodium wherein a series of glycosyl groups such as glucosyl- , salt of ascorbic acid 2 - glucoside ( A ) , anhydrous crystalline 10 maltosyl- , and maltotriosyl- groups bind to the C - 2 position sodium salt of ascorbic acid 2 - glucoside (B ) , hydrous crys of L - ascorbic acid via an a - fashion as disclosed in Japanese talline ascorbic acid 2 - glucoside as Control 1 ( C ), and Patent Kokai Nos. 135992 /91 , 139288 /91 , etc . ; and 2 - 0 -B anhydrous crystalline ascorbic acid 2 - glucoside as Control 2 D - galactosyl- L - ascorbic acid (ascorbic acid 2 - galactoside ) , ( D ). wherein a galactosyl group binds to the C - 2 position of FIG . 5 A single - crystal X - ray diffraction patterntem for a 1515 L - ascorbic acid via a B - fashion as disclosed , for example , in hydrous crystalline sodium salt of ascorbic acid 2 - glucoside . Japanese Patent Kokai No . 263790 /94 . Examples of the acyl derivatives (or fatty acid ester BEST MODE FOR CARRYING OUT THE derivatives) of L - ascorbic acid include ascorbic acid palmi INVENTION tate ester, ascorbic acid dipalmitate ester , ascorbic acid 20 tetrahexyldecanoic acid ester , ascorbic acid cholesterol ester, The present invention relates to an external dermal com - etc ., as disclosed in Japanese Patent Kokai Nos . 10505 /84 . position for anti - ageing , which contains an aqueous medium 104971 / 88 , 247956 / 94 , 2004 - 331524 , etc . Examples of as a base material and one or more ingredients selected from phosphoryl derivatives of L - ascorbic acid include ascorbic L - ascorbic acid , derivatives thereof , and their salts as an acid 2 -phosphoric ester and metal salts thereof as disclosed effective ingredient( s ) ; a basic skin care containing the 25 in Japanese Patent Kokai Nos . 152613 / 86 , 339123 / 93 , 2002 external dermal composition ; and a method for producing 3330 , 2006 -63060 , etc . the same. Hereinafter , the above external dermal composi- Among the above -mentioned derivatives of L -ascorbic tion of the present invention is firstly explained and then the acid , glycosyl derivatives of L -ascorbic acid are most favor basic skin care and the method of the same according to the ably used because of their high stableness , and among which present invention are explained . 30 2 - O - a - D - glucosyl- L - ascorbic acid , wherein a glucosyl A . External Dermal Composition for Anti - Ageing group binds to the C - 2 position of L - ascorbic acid via an The external dermal composition for anti - ageing of the a - fashion (abbreviated as " ascorbic acid 2 - glucoside " present invention ( called simply " external dermal composi- throughout the specification , hereinafter ) is most preferable . tion " , hereinafter ) contains one or more ingredients selected Ascorbic acid 2 - glucoside is a derivative of L - ascorbic acid , from L -ascorbic acid , derivatives thereof, and their salts as 35 which was explored to overcome the above - identified defect an effective ingredient( s ) . L -Ascorbic acid is a compound of L -ascorbic acid , has groundbreaking properties of show that exerts an important physiological function in living ing no reducibility , having stableness, and exerting the bodies as vitamin C and it has been also used as an intrinsic physiological activities of L - ascorbic acid after antioxidant and anti - inflammatory ; and it has been widely being decomposed into L -ascorbic acid and D - glucose by in used as a useful component in a cosmetic field because of its 40 vivo enzymes in living bodies . As disclosed , for example , in skin -whitening effect and collagen -production - enhancing Japanese Patent Kokai Nos. 135992 / 91, 139288 / 91, etc . , action . Since L -ascorbic acid effectively prevents or ascorbic acid 2 - glucoside can be produced on an industrial improves wrinkles , fine wrinkles, blemishes , and saggings in scale by a method of allowing cyclomaltodextrin glucano the skin when incorporated in external dermal compositions , transferase as a saccharide - transferring enzyme to act on a it can be used as an effective ingredient in the external 45 solution containing L -ascorbic acid and amylaceous sub dermal composition of the present invention . stance , and then allowing glucoamylase to act on the result L - Ascorbic acid , however, has a defect that it is quite ing ascorbic acid 2 - glycoside . unstable and susceptive to oxidation decomposition to lose Suitable examples of such ascorbic acid 2 - glucoside are its physiological activities due to its reducibility . Because of those in a partially or wholly crystalline form ; the higher the this, L -ascorbic acid requires extreme caution in storing and 50 ratio of crystals in the whole ascorbic acid 2 - glucoside used , handling , and it should be foreseen the amount that will be the higher the purity of ascorbic acid 2 - glucoside and further decomposed by oxidation before its use and should be the more stable the property thereof. The whole content of incorporated in an amount that far exceeds its possible ascorbic acid 2 - glucoside used , however, should not neces requisite amount. Accordingly , more preferable examples of sarily be in a wholly crystalline form and it can be in the the effective ingredients used in the external dermal com - 55 form of a particulate composition containing crystals par position of the present invention are derivatives of L - ascor- tially coexisted with amorphous ascorbic acid 2 - glucoside . It bic acid and salts thereof that are more stable than L -ascor - is well known that ascorbic acid 2 - glucoside exists in an bic acid per se and capable of exerting the intrinsic functions anhydrous crystalline form . Examples of crystals of ascorbic of L - ascorbic acid released therefrom in vivo . acid 2 - glucoside suitably used in the present invention Any derivatives of L -ascorbic acid suitably used as the 60 include a particulate composition containing anhydrous effective ingredients of the external dermal composition of crystalline 2 - 0 - C - D - glucosyl- L -ascorbic acid as disclosed the present invention should not specifically be restricted to in Japanese Patent Kokai No. 135992 / 91 and International specific ones as long as they in themselves are more stable Patent Publication No . WO2012 / 121297 . Examples of com than L - ascorbic acid and capable of exerting the intrinsic mercialized ones include " AA2G ” , a product name of a functions of L - ascorbic acid after releasing L - ascorbic acid 65 particulate composition containing anhydrous crystalline in vivo . Examples of such derivatives of L - ascorbic acid ascorbic acid 2 - glucoside , commercialized by Hayashibara usable as the effective ingredients of the external dermal Co ., Ltd ., Okayama, Japan . US 10 , 111 , 822 B2 10 The L -ascorbic acid or the derivatives thereof used as the group of Pbca ( # 61) and a lattice constant of a = 6 .9733 Å , effective ingredient( s) of the external dermal composition of b = 14 .4839 Å , c = 19 .3221 Å , when determined on X - ray the present invention can be those in a salt form as long as crystal structural analysis . they are dissociated into L -ascorbic acid or derivatives For comparison , according to the later described induc thereof when mixed with an aqueous medium . 5 tively - coupled plasma emission spectrometry , the sodium Examples of salts particularly preferably used as the content in the anhydrous crystalline sodium salt was about effective ingredient( s ) in the external dermal composition of 8 . 7 % by mass. While , the theoretical sodium content is 8 . 8 % by mass which well coincides with the measured value , on the present invention include sodium salt of ascorbic acid the assumption that the above - identified anhydrous crystal is 2 - glucoside . Such sodium salt of ascorbic acid 2 -glucoside 10 composed of ascorbic acid 2 - glucoside and sodium salt and can be obtained , for example , by neutralizing an aqueous the quantitative ratio is an atom of sodium and 1/ 2 molecule solution of ascorbic acid 2 - glucoside with an alkali, and of sodium hydroxide against one molecule of ascorbic acid drying the resulting mixture . Varying depending on pH , 2 - glucoside . At this point, the molar ratio of ascorbic acid since at least a part of sodium salt of ascorbic acid 2 - glu 2 - glucoside to sodium is about 1 : 1. 5 , meaning that two coside is dissociated into ascorbic acid 2 - glucoside and 15 molecules of ascorbic acid 2 - glucoside contain three mol sodium when dissolved in an aqueous medium , it can be ecules of sodium . As shown in the later described result in particularly preferably used in the present invention simi the measurement of moisture content, the hydrous crystal larly as ascorbic acid 2 - glucoside. line sodium salt of ascorbic acid 2 - glucoside has a moisture Similarly as in ascorbic acid 2 - glucoside , sodium salt of content of about 15 % by mass. Assuming that the hydrous ascorbic acid 2 - glucoside can be more preferably used in a 20 crystal contains ascorbic acid 2 - glucoside, sodium , and crystalline form . A crystalline sodium salt of ascorbic acid sodium hydroxide in the same molar ratio as in the anhy 2 - glucoside is a novel crystal created by the present inven - drous crystal , the molar ratio of ascorbic acid 2 - glucoside tors . Although crystalline powders of aluminum salt or zinc and water molecule is about 1 :4 , indicating that the hydrous salt of ascorbic acid 2 - glucoside have been reported in crystal contains four molecules of crystallization water Japanese Patent Kokai No . 220081/ 94 , there exists no report 25 against one molecule of ascorbic acid 2 - glucoside . on crystalline sodium salt of ascorbic acid 2 - glucoside . In In general , organic compounds are said to have crystal the above - identified patent publication , crystalline powders polymorphism , and even the same compound , it can take of aluminum salt or zinc salt of ascorbic acid 2 - glucoside are plurality of different crystalline structures and may have reported to have respectively obtained by dissolving ascor - different properties , including solubility depending on the bic acid 2 - glucoside and an aluminum compound in cold 30 crystalline structures . In the case of using organic com water, stirring the resulting solution , centrifuging the solu - pounds, for example , using them as effective ingredients of tion , and either freeze- drying the resulting supernatant or external dermal compositions and basic skin cares , it is quite adding NaOH to the resulting zinc compound , followed by beneficial to obtain their crystals , when they can exist in a stirring the mixture , centrifuging the resultant, adding the crystalline form , and to reveal their crystalline structures for resulting precipitate to an aqueous solution of ascorbic acid 35 the sake of stably maintaining and securing properties 2 - glucoside, filtering the aqueous solution , and freeze - dry - suitable for their applications . The external dermal compo ing the filtrate . The present inventors repeated similar meth - sition and the basic skin care of the present invention use ods as those of the above patent publication to obtain a sodium salt of ascorbic acid 2 - glucoside as an appropriate crystalline sodium salt of ascorbic acid 2 - glucoside ; how effective ingredient, and a crystalline sodium salt of ascorbic ever, none of the methods , which had been reported to have 40 acid 2 - glucoside has now been obtained by the present succeeded in obtaining crystalline powders of aluminum salt inventors who revealed that the crystalline sodium salt exists or zinc salt of ascorbic acid 2 - glucoside, yielded a crystalline in an anhydrous or hydrous crystalline form , and analyzed powder of sodium salt of ascorbic acid 2 - glucoside . their characteristic powder X -ray diffraction patterns and The present inventors subsequently continued researching crystalline structures . Accordingly , in the case of using on and repeated trial and error and unexpectedly succeeded 45 sodium salt of ascorbic acid 2 - glucoside in the form of the in obtaining a crystalline sodium salt of ascorbic acid above - identified anhydrous - or hydrous - crystal, they can be 2 - glucoside by adding an excessive amount of sodium easily prepared into highly purified materials and easily hydroxide in an aqueous solution to ascorbic acid 2 - gluco - confirmed their handlings , effectiveness , and safeness , as side into an alkaline solution , adding an organic solvent to well as being always expected to have consistent and known the alkaline solution , and allowing the resulting mixture to 50 stable - properties as quite advantageous merits . stand . The method for producing crystalline sodium salt of As shown in the later described Experiments , the crys ascorbic acid 2 - glucoside used in the present invention talline sodium salt of ascorbic acid 2 - glucoside found by the should not specifically be restricted as long as it yields a present inventors can exist in any of a hydrous crystalline or desired crystal; hydrous crystalline sodium salt of ascorbic anhydrous crystalline form ; the one in a hydrous crystalline 55 acid 2 - glucoside can be obtained by dissolving ascorbic acid form has characteristic diffraction peaks at diffraction angles 2 - glucoside in an aqueous sodium hydroxide solution , add ( 20 ) of 6 . 8° , 8 .2° , 14 . 3°, 17 . 8° , and 18 . 4° , when determined ing an organic solvent to the solution , allowing the resulting on powder X - ray diffraction analysis, and the other in an solution to stand to precipitate crystals, and collecting the anhydrous crystalline form has characteristic diffraction precipitated crystals by using a solid -liquid separation peaks at diffraction angles (20 ) of 8 .0° , 9 .0° , 16 .4° , 17 . 9°, 60 method such as centrifugation . Ascorbic acid 2 - glucoside and 20 .8° , when determined on powder X - ray diffraction with a relatively high purity is desirably used as a material, analysis . For reference , the present inventors succeeded in and usually an anhydrous crystalline ascorbic acid 2 - gluco obtaining a single crystal with a size that affords X - ray side with a purity of at least 90 % by mass , desirably, at least crystal structural analysis for the hydrous crystalline sodium 95 % by mass , and more desirably , at least 99 % can be salt of ascorbic acid 2 - glucoside ; and revealed that, as shown 65 suitably used as the material. in the later described Experiment, the hydrous crystal Washing the resulting hydrous crystal with an aqueous belongs to an orthorhombic system and exhibits a space ethanol can make it into a high purity hydrous crystal. The US 10 , 111, 822 B2 12 obtained hydrous crystal can be , if necessary , pulverized and sodium salt of ascorbic acid 2 - glucoside or anhydrous dried into a particulate composition containing hydrous crystalline ascorbic acid 2 - glucoside in the external dermal crystalline sodium salt of ascorbic acid 2 - glucoside . The composition or the basic skin care of the present invention hydrous crystal obtained by the above method can be is usually 0 .001 % by mass or more, preferably , 0 .01 to 50 % converted into anhydrous crystalline sodium salt of ascorbic 5 by mass, more preferably , 0 . 1 to 20 % by mass , and more acid 2 - glucoside by drying it in vacuo while heating . The preferably , 1 to 10 % by mass in terms of the total anhydrous obtained anhydrous crystal can be reconverted into hydrous crystalline L - ascorbic acid against the mass of the compo crystal by allowing it to absorb moisture under a relative sition or the basic skin care . When the amount is below the humidity of at least 75 % . A particulate composition con - above lower limit or over the above upper limit, it is not taining hydrous or anhydrous crystalline sodium salt of 10 preferable because it may distinctly reduce or not exert the ascorbic acid 2 - glucoside can be obtained by spray -drying a desired effects . massecuite prepared by adding an organic solvent to sodium As described above , ascorbic acid 2 - glucoside and /or salt of ascorbic acid 2 - glucoside to precipitate crystals . sodium salt thereof can be preferably used as the effective Anhydrous or hydrous crystalline sodium salt of ascorbic ingredient ( s ) of the external dermal composition of the acid 2 - glucoside exhibits alkalinity , when dissolved in 15 present invention . Sodium salt of ascorbic acid 2 - glucoside , water, as a characteristic feature thereof. This feature con - at least a part of which dissociates into ascorbic acid trasts sharply with anhydrous crystalline ascorbic acid 2 - glu - 2 - glucoside and sodium in an aqueous medium to form coside that exhibits a relatively strong acidity when dis - ascorbic acid 2 - glucoside . Ascorbic acid 2 - glucoside is solved in water. Because of this , the novel crystalline hydrolyzed into L - ascorbic acid and D - glucose by the action sodium salt of ascorbic acid 2 - glucoside created by the 20 of in vivo enzymes in living bodies , for example , a - glu present inventors can be preferably used in various uses , cosidase , to exert functions as L -ascorbic acid . Accordingly , where the amounts and the forms of use thereof and even the the incorporation of an a - glucosidase inhibitor into the use thereof per se are restricted , because conventional anhy - external dermal composition of the present invention as drous crystalline ascorbic acid 2 - glucoside exhibits a rela - needed will delay the formation of L -ascorbic acid from the tively strong acidity when in an aqueous solution form . 25 composition when applying the composition to the skin , When used in soap -related external dermal compositions resulting in imparting its anti - ageing effect in a durable or that require a slight alkalinity , for example , soaps , sham - slow - acting manner. Conversely , the external dermal com poos , cleansing foams, body soaps , etc . , conventional par - position of the present invention can be imparted an imme ticulate compositions containing anhydrous crystalline diate effect by optionally incorporating thereunto an a - glu ascorbic acid 2 - glucoside inevitably require a handling of 30 cosidase activator to accelerate the formation of L - ascorbic neutralization of acid solutions of ascorbic acid 2 - glucoside acid when applied to the skin . dissolved in an aqueous medium prior to use and also require Any competitive and non -competitive inhibitors can be the addition of buffers for pH control, but since aqueous used as the above - identified a - glucosidase inhibitor. Con solutions, obtained by dissolving crystalline sodium salt of crete examples of such include starch hydrolyzates such as ascorbic acid 2 - glucoside in water, usually exhibit alkalinity 35 maltotriose , maltotetraose , maltopentaose , maltoheptaose , and this would eliminate the need for a handling of neutral- and panose ; sugar alcohols such as maltitol, maltotriitol, izing ascorbic acid 2 - glucoside with an alkali , as well as maltotetraitol, maltopentaitol, maltohexaitol, maltoheptai often for the combination use with any buffer . tol, erythritol, 1 - thio - D - glucitol ; monosaccharides such as In the case of using anhydrous or hydrous crystalline arabinose , fucose , 2 - deoxy - D - galactose , xylose , ribose , sodium salt of ascorbic acid 2 - glucoside in combination with 40 tagatose , ribulose , lyxose , xylulose , and a -methyl - D - xylo anhydrous crystalline ascorbic acid 2 - glucoside , an appro - side ; oligo - or poly -saccharides such as oligosaccharides priate control of their composition ratio can provide , as a derived from fukoidan and polysaccharides derived from merit , an aqueous solution of ascorbic acid 2 -glucoside with soy beans; nucleotides such as adenylic acid , guanylic acid , a pH within a prescribed pH range , for example , within a cytidylic acid , uridylic acid , and inosinic acid ; nucleosides slightly alkaline to a slightly acidity range , when dissolved 45 such as guanosine, deoxyguanosine , adenosine , deoxyade in an aqueous medium . When anhydrous or hydrous crys - nosine , cytidine , uridine , inosine , and deoxyinosine ; and talline sodium salt of ascorbic acid 2 - glucoside is used in plant extracts such as Asian ginseng , Aloe barbadensis combination with anhydrous crystalline ascorbic acid 2 - glu - Miller, Hypericum , Malvaceae (mallows ) , Salacia reticu coside , there can provide , as a merit , various compositions, lata , Connarus cochinensis, Sapium discolor , Xanthophyl which are preferably adjusted to give a pH ranging from a 50 lum annamense , Paris tetraphylla , Dimocarpus longan , slightly alkaline pH to a slightly acidic pH as a whole , Erythroxylon cambodianum , Diospyros malabarica , touch , including the external dermal compositions and the basic Careya arborea , mulberry tree, Semecarpus cochinchinen skin cares of the present invention , without using any sis , Calophyllum calaba , Shorea guiso , Duabanga sonnera additional alkali other than the anhydrous or hydrous crys - tioides , Cratoxylon formosum , Archidendron Turgidum , talline sodium salt of ascorbic acid 2 - glucoside . In using 55 Nauclea officinalis , Eupatorium odoratum , Hibiscus mesnyi, them both in combination , anhydrous crystalline ascorbic Myrcia sphaerocarpe, Milletia diptera, Milletia conraui, acid 2 - glucoside and anhydrous or hydrous crystalline Ascophyllum nodosum , Brucea javanica , Mangifera indicia , sodium salt of ascorbic acid 2 - glucoside can be weighed in Sesbania grandiflora , Glycyrrhiza uralensis, Rumex an amount corresponding to respective composition ratios bucephalophorus, Murtex communis, Taraxacum officinale , before use , however , it is convenient to make them into 60 Viscum album , Ganoderma lucidum , Pinus densiflora , compositions , which can be previously prepared by mixing Penarus schulzei , Origanum majorana , Grifola frondosa , anhydrous crystalline ascorbic acid 2 - glucoside and anhy - Sangzhi ( Ramulus mori ), Lobelia chinensis , Angelica acuti drous or hydrous crystalline sodium salt of ascorbic acid loba (dong quai) , Syzygium aromaticum , Commelina com 2 - glucoside in a prescribed composition ratio , preferably, in munis , Salacia reticulata , Eucommia ulmoides, Angylocalyx a composition ratio of 60 : 40 to 45 : 55 by mass on a dry solid 65 boutiqueanus, Arachniodes standishii, laurel, Psidium gua basis ( d . s . b . ) , to meet the pH requisite for a desired com - java (guava ) , astringent coats of chestnuts and peanuts, and position . The amount of anhydrous or hydrous crystalline Oryza sativa subsp . Javanica . US 10 , 111 , 822 B2 13 14 Examples of the a - glucosidase activator include plant a cid , vitamin A group , derivatives of glycyrrhizinate , allan extracts such as Arnica montana , german camomile flower , toin , diclofenac , felbinac , ibuprofen , ketoprofen , loxopro Salvia officinalis, soy beans, Artemisia indica var. maximo - fen , and salts thereof, one or more of, all of which can be wiczii ; and microorganisms such as yeasts , bifidobacteria , used in combination . Among the above - identified plant and lactic acid bacteria . 5 extracts or compounds having a skin - turnover - improving Since the L -ascorbic acid , derivatives thereof, and their action , preferably used are extracts of plants such as those of salts used in the present invention exert in themselves an the family Cupressaceae including Thujopsis dolabrata ; action of improving the turnover of the skin and an action of Ginkgoaceae including Ginkgo biloba ; Rutaceae including maintaining or enhancing the barrier function and the Phellodendri cortex , Citrus sinensis, Citrusxparadisi , Cit hyaluronic acid production in the skin , they can be advan - 10 rus junos, and Citrus limon ; Lamiaceae including Mentha , tageously used alone as effective ingredients of the external Menthaxpiperita L ., Perilla frutescens var . crispa , and Ros dermal composition of the present invention ; however , if marinus officinalis L . ; Saururaceae including Houttuynia necessary , when incorporated with the later described plant cordata ; and Eucommiaceae including Eucommia ulmoides . extracts or compounds having a skin - turnover- improving Among which , since extracts of Thujopsis dolabrata , action , the anti- wrinkle action , anti - fine wrinkle action , 15 Ginkgo biloba , Phellodendri cortex , Citrus sinensis , Perilla skin -whitening action , anti- blemishes , and anti- saggings in frutescens var. crispa , Houttuynia cordata , and leaves of the skin , as well as the above functions and effects exerted Eucommia ulmoides, which have later described glycation by the L -ascorbic acid , derivatives thereof, and their salts as inhibitory action , are most suitably used in combination with the effective ingredients can be even increased up to a level any of L -ascorbic acid , derivatives thereof, and their salts . of over their additive effects ; the combination use of the 20 The above - identified plant extracts or compounds having external dermal composition of the present invention with a skin - turnover- improving action are suitably added to one any of the above plant extracts or compounds can be part by mass of one or more of L - ascorbic acid , derivatives particularly useful in practicing the present invention thereof , and their salts , which are contained in the external because they do not hinder the action of improving the skin dermal composition of the present invention or cosmetic turnover, the effect of maintaining or enhancing the barrier 25 lotions , face cleansing cosmetics, serums, milky lotions , or function , and the action of maintaining or enhancing the creams, in an amount of 0 . 00001 part by mass or more, hyaluronic acid production in the skin . preferably , 0 . 0001 to 50 parts by mass, more preferably , ( Plant Extracts or Compounds Having a Skin - Turnover - 0 .001 to 10 parts by mass, and more preferably , 0 .01 to 1 part Improving Action ) by mass . When the composition ratio is below the above Examples of the above - identified plant extracts or com - 30 lower limit or over the above upper limit, it is not preferable pounds having a skin - turnover - improving action include because the ratio may distinctly reduce or may not exert the extracts of plants such as Sesamum indicum , Rehmannia , desired effects . Amygdalus persica , Glycyrrhiza uralensis, Cactus , wheat Since the L - ascorbic acid , derivatives thereof, and their ( Triticum vulgare ) germ , Fragaria vesca , Salvia officinalis, salts used in the present invention exert in themselves a Mentha , Menthaxpiperita , Houttuynia cordata , Uncaria 35 skin - turnover -improving action and an action of maintaining tomentosa , Perilla frutescens var. crispa , Eriobotrya or enhancing the barrier function and the hyaluronic acid japonica , Camellia japonica , Ziziphus jujuba, Polygonum production in the skin , they can be advantageously used tinctorium Lour. , Akebia quinata , Angelica keiskei, Thujop - solely as the effective ingredient( s ) of the external dermal sis dolabrata , Malpighia emarginata , Althaea officinalis , composition of the present invention ; however, the above Aloe barbadensis Miller , Ginkgo biloba , Phellodendron 40 identified functions and effects exerted by them and their amurense , Hypericum erectum , Olea europaea ( olive ], Cit anti -wrinkle action , anti - fine -wrinkle action , as well as their rus sinensis , Matricaria recutita , quince seed , Citrus para anti -blemish and anti- sagging actions , can be augmented up disi, Cinnamomum Loureiri Nees, Alpinia zerumbet, San - to a level of over additive effects when the above - identified guisorba officinalis , Betula platyphylla , Averrhoa plant extracts or compounds having a skin -turnover - improv carambola , Swertia L . , Morus alba , Camellia sinensis , 45 ing action , let alone the later described plant extracts or Syzygium aromaticum Merr. et Perry ., Daucus carota subsp . compounds having a glycation - inhibitory action , are incor sativus, Hamamelis L . , Rosa , Rubus ellipticus, Ruscus acu - porated in combination . Further, since the later described leatus, Prunus domestica , Paeonia suffruticosa , Aesculus plant extracts or compounds do not hinder the skin - turnover hippocastanum , Oenothera biennis , Rodgersia podophylla , improving action , the action ofmaintaining or improving the Eucalyptus, Saxifraga stolonifera , Citrus junos, Coix 50 skin -barrier - function and the hyaluronic acid production in lacryma -jobi L . var . mayuen Stapf, Orchidaceae, Citrus the skin exerted by L -ascorbic acid , derivatives thereof, and limon , Astragalus sinicus, Rosa canina , Rosmarinus offici - their salts , the combination use with the above plant extracts nalis L ., Prunus, Fucus, Alocasia odora (Roxb .) C Koch , or compounds having a skin -turnover - improving action is Tinospora capillipes Gagnep . , Cnidium monnieri, Peumus particularly useful in practicing the present invention . boldus, Ricinus communis L ., Sassafras albidum , Angelica 55 (Plant Extracts or Compounds Having a Glycation - Inhibi keiskei , Euphorbia ebracteolata , Boswellia carterii Birdw . , tory Action ) Euphorbia kansui, Impatiens balsamina L ., Forsythia sus - Examples of plant extracts or compounds having a gly pensa , Medicago sativa , Commiphora myrrha, Stillingia cation - inhibitory action include extracts of plants such as sylvatica , Lycopodium clavatum , Centipeda minima, Torilis Cynara scolymus , Euphrasia officinalis, Pilea mongolica , japonica , Ficus, Magnolia liliflora Magnolia , Magnolia 60 Elaeagnus umbellata , Agrimonia eupatoria , Agni fruit, Ake denudata , Betula platyphylla , Chenopodium hybridum L ., bia quinata , fruit of Euterpe oleracea, Withania somnifera , Lonicera japonica , Gardenia jasminoides, Prunus persica , Thujopsis dolabrata , Acacia catechu , Quercus variabilis, and Zizyphus jujuba ; and others including sea algae , Chlo Gynostemma pentaphyllum , Pimpinella anisum L ., Hama rellaceae , royal jelly, citrus unshiu peel, carnitine , nicotinic melis virginiana , Alistin , Epimedium grandiflorum var. thun acid amide, pyridoxine hydrochloride, hyaluronic acid , gly - 65 bergianum , Fallopia japonica (Houtt . ) Ronse Decr. , Ginkgo colic acid , citric acid , lactic acid , malic acid , tartaric acid , biloba , Pyrola japonica , Fragaria , Lilium tenuifolium Fis 2 -hydroxybutyric acid , 3 - hydroxybutyric acid , tartronic cher , Gloiosiphonia capillaris, Ficus erecta , bark of Tabe US 10 , 111, 822 B2 15 16 buia spp . , Acer palmatum Lilium maculatum Thunb . , Foen - anthraquinone ; 4 - aminophenol; 1 , 3 , 5 - trihydroxybenzene , iculum vulgare , Hamamelis virginiana , Gaultheria kojic acid ; 3 , 4 - dihydroxy - phenylacetate ; caffeine acid ; ifen procumbens, Curcuma longa Linn , Prunus mume, Quercus prodil ; 6 -hydroxy - 2 ,5 ,7 , 8 -tetramethylchroman - 2 -carboxy salicina , Epimedium brevicornum Maxim , Rosa multiflora , late ; 6 -hydroxyindole ; 7 -hydroxy - 4 , 6 - dimethylphthalide ; Echinacea angustifolia , Eleutherococcus senticosus, Cytisus 5 a - lipo acid , 4 -hydroxychalcone ; protein hydrolyzates of scoparius , Gentianella alborosea (Gilg ) Fabris , Sambucus pearls ; aminoguanidine , erythrosine sodium L - ergothion nigra , Ilex paraguariensis , Borassus flabellifer, Phelloden eine , resveratrol; hydroxystilbenes such as 3 , 3 ', 5 '5 -tetrahy dron amurense , Coptis japonica ( Thunb .) Makino , Silybum droxystilbene ; oxindole ; carnosine; salicylic acid ; salsolinol marianum , Avena sativa , Cardamine scutata , Salsola koma - hydrobromide ; sinapinic acid ; tocopherylnicotinate ; nico rovii , Lilium rubellum , Lapsana apogonoides , Lilium lanci- 10 tinic - acid amide ; nordihydroguaiaretic acid ; proanthocya folium , Origanum vulgare , Citrus sinensis, seed of Cucur - nin ; mannitol; hydrolyzed casein ; hydrolysable tannin ; cat bita , bark of Erythroxylum catuaba , Lilium speciosum , echol; chlorogenic acid and derivatives thereof such as Paullinia cupana , Hibiscus sabdariffa , Asarum nipponicum , chlorogenic acid , isochlorogenic acid , neochlorogenic acid , Tussilago farfara , Platycodon grandiflorus, Rumex japoni cryptochlorogenic acid , and feruloyl caffeoylquinic acid ; cus , Clerodendron trichotomum , Mallotus philippinensis, 15 and others such as leucocyanidin , prunin , procyanidol oli Lilium medeoloides A . Gray , Juglans, Vaccinium vitis - idaea gomer, and glycosyl rutin . Among the above ingredients , the L . ,Monochoria vaginalis var. plantaginea , Eisenia arborea following can be more suitably used in combination with the Areschoug , Punica granatum , Ipomoea batatas, Smilax L - ascorbic acid , derivatives thereof, and their salts used in regelii Killip & Morton , Crataegus cuneata , Pellionia the present invention to effectively enhance anti -wrinkle minima, Perilla frutescens var. crispa , Psophocarpus 20 action , anti -small wrinkle action , skin -whitening action , tetragonolobus ( L . ) D . C . , Filipendula multijuga , Paeonia anti -blemish action , and anti - sagging action , exerted by the lactiflora , Rheum palmatum , Aster scaber, Chenopodium L -ascorbic acid , derivatives thereof, and their salts : Extracts album , Aster ageratoides ssp . Leiophyllus, Plantago major, of Withania somniferous , Thujopsis dolabrata , Acacia cat Centella asiatica , Fagopyrum esculentum , Lilium formosa - echu , Ginkgo biloba , Gaultheria procumbens, Phelloden num A . Wallace , Cardamine scutata , Davilla rugosa , Lilium 25 dron amurense, Citrus sinensis , seed of Cucurbita , bark of nobilissimum Makino , Cordia salicifolia , Syzygium aromati - Erythroxylum catuaba , Mallotus philippinensis , glucosyl cum Merr . et Perry , Cassia angustifolia , Centella asiatica rutin , Vaccinium vitis - idaea L ., Perilla frutescens var. ( L . ) Urb ., Bellis perennis, Anethum graveolens , Harpogo - crispa , Fagopyrum esculentum , Davilla rugosa , Houttuynia phytum procumbens , Farfugium japonicum ( L . ) Kitam , cordata , Elatostema japonicum var. japonicum , Crasso Lilium longiflorum , root of Harpogophytum procumbens , 30 cephalum crepidioides, Actinidia deliciosa , Pleioblastus lin Rubus suavissimus S . Lee , Prunus persica , Houttuynia earis , Rubus croceacanthus, unripe fruit of Malus pumila , cordata , Rosa roxburghii , leaves of Eucommia ulmoides , leaves of Diospyros kaki Thunberg, leaves of Glycyrrhiza Solanum lycopersicum , Potentilla tormentilla Schrk (Rosa glabra ( licorice ) , leaves of Alpinia zerumbet, extracts of ceae ), Rumex crispus, Sambucus racemosa subsp . sieboldi Eucommia ulmoides, equol, isoflavone , ifenprodil, protein ana , Trapaeolum majus Linn . , Aster microcephalus var. 35 hydrolyzates of pearls, catechol, caffeic acid , and prunin . ovatus, Mentha , Lilium longiflorum , Lespedeza sp ., Colo Among the above plant extracts having a glycation -inhibi casia gigantea , Passiflora incarnata , Passiflora edulis Sims, tory action , suitably used are extracts of plants of the family roots of Pfaffia , Artocarpus heterophyllus, Prunus cera - Cupressaceae such as Thujopsis dolabrata , those of the soides var. campanulata , Helianthus annuus, Elatostema family Ginkgoaceae such as Ginkgo biloba , those of the japonicum var. japonicum , Lilium concolor, Lapsana 40 family Rutaceae such as Phellodendoron amurense Rupre apogonoides, Areca catechu , Petasites japonicus ( Siebold et cht, Citrus sinensis , and Citrus limon , those of the family Zucc . ), Maxim , Lablab purpureus ( L . ) Sweet, Cimicifuga Labiatae such as Perilla frutescens var . crispa and Rosmari racemosa , Actaea racemosa , Crassocephalum crepidioides , nus officinalis L ., those of the family Saururaceae such as Actinidia polygama , Machilus odoratissima, Pinus, Lith Houttuynia cordata , and those of the family Eucommiaceae ocarpus edulis , Llex paraguariensis , Lilium candidum , Sily - 45 such as Eucommia ulmoides ; wherein extracts of Thujopsis bum marianum , Staphylea bumalda , Stauntonia hexaphylla , dolabrata , Ginkgo biloba , Phellodendoron amurense Rupre Nemacystus decipiens , Salicaceae , Hemerocallis fulva var. cht, Citrus sinensis , Perilla frutescens var. crispa , Hout kwanso , Annona montana Macfady , Lilium auratum , Ipom - tuynia cordata , and Eucommia ulmoides are most preferably oea aquatica , Aster yomena , seeds of Litchi chinensis , used in combination with L - ascorbic acid , derivatives Lilium regale , Pleioblastus linearis, Rubus rosaefolius, 50 thereof, and their salts in the present invention . Since the unripe fruit of Malus pumila , flowers of Tilia cordata , combination use of these plant extracts or compounds hav Aspalathus linearis , Lactuca sativa , Citrus limon , Cym - ing a glycation - inhibitory action with one or more of bopogon citratus , Thymusxcitriodorus , Aloysia citrodora , L - ascorbic acid , derivatives thereof, and their salts effec Melissa officinalis , Rosa canina , flower buds of Rosa dama - tively inhibits the formation of AGEs, undesirable accumu scena , Rosmarinus officinalis L . , Rosaxcentifolia L ., Laurus 55 lation of AGEs in the skin tissue can be lowered or inhibited , nobilis , Aerides rosea , Haematoxylum campechianum , San - and physical and physiological changes (deterioration ) guisorba officinalis , Astragalus sinicus , leaves of Diospyros formed in collagen by disordered cross -links formed in kaki Thunberg , leaves of Glycyrrhiza uralensis , episperms collagen intra - and inter -molecularly . Accordingly , skin age of Glycine max, seeds of Oryza sativa subsp . javanica , ing such as the reduction of wrinkles, rough skin , dullness , leaves of Alpinia zerumebet, Lilium tenuifolium Fischer , 60 or the reduction of supple skin can be effectively prevented Salix sp . , leaves of Eucommia ulmoides , and leaves of or improved . When used in combination with one or more Angelica keiskei; extracts of sea algae such as Gloiopeltis L -ascorbic acid , derivatives thereof, and their salts , plant complanata (Harvey ) Yamada , Gloiopeltis furcata (Postels extracts having a glycation - inhibitory action can be advan et Ruprecht) J . Agardh , and Gloiopeltis tenax ( Turner ) J . tageously masked in their intrinsic off -taste and off - flavor Agardh ; extracts of raw coffee beans , lees of liquor distilled 65 and improved in their storage stability by a large margin . from sweet potatoes, mycelia of Agaricus blazei, etc . , equol ; Examples of the amount of the above -identified plant isoflavone ; 1 ,4 -anthraquinone ; l -amino -2 -hydroymethyl extracts or compounds, having a glycation - inhibitory action , US 10 , 111 , 822 B2 17 18 suitably incorporated into the external dermal composition ethylether , ethyleneglycolmonophenylether , ethyleneglycol of the present invention , or cosmetic lotions, face washes , monohexylether, diethyleneglyocolmonomethylether, serums, milky lotions , or creams are usually at least 0 . 0001 triethyleneglyocolmonoethylether, monooley1 glyceryl part by mass , preferably , 0 .001 to 50 parts by mass , more ether , diethyleneglycolmonoethylether , ethyleneglycol preferably , 0 .001 to 10 parts by mass , and more preferably , 5 monoethylether, ethyleneglycolmonobutylether , and dieth 0 .01 to 1 part by mass to one part by mass of the total amount yleneglycoldibutylether ; sugar alcohols such as sorbitol, of one or more of L -ascorbic acid , derivatives thereof, and xylitol , erythritol, mannitol, maltitol, maltotriitol, maltotet their salts . Any amounts below the above lower limit or over raitol, and hydrogenated products of starch hydrolyzates ; the above upper limit are not preferable because the desired saccharides such as sucrose , rhamnose , glucose , fructose , effects may be distinctly lowered or even not exerted . 10 galactose , mannose , threose , xylose , arabinose , fucose , In the case of incorporating into the external dermal ribose , deoxyribose , maltose , maltotriose , maltotetraose , tre composition of the present invention the above plant extracts halose, lactose , raffinose, glucuronic acid , glucuronic acid , or compounds having a glycation - inhibitory action along saccharide derivatives of trehalose ( including glucosyl tre with the above plant extracts or compounds having a skin - halose , maltosyltrehalose, maltotriosyl trehalose , and malto turnover - improving action usually in roughly equal amount, 15 tetraosyl trehalose ) , sulfated trehalose , dextrin , cyclodextrin , i . e . , in a total amount of 0 .01 to 1 % by mass to the cyclotetrasaccharide ( cyclonigerosylnigerose ) having a composition , and further with one or more of L - ascorbic structure of cyclo { ?6 ) - a - D - glucopyranosyl - ( 1 > 3 ) - a - D acid , its derivatives, and salts thereof in a total amount of 1 glucopyranosyl- (1 6 ) - a - D - glucopyranosyl- ( 1 - 3 ) - a - D to 10 % by mass , d . s . b . , to the total composition , the com - glucopyranosyl- ( 1 } disclosed in International Patent bination action exerted by the above plant extracts or 20 Application No . WO 02 / 10361 , cyclotetrasaccharide ( cy compounds having a glycation - inhibitory action and those clomaltosylmaltose ) having a structure of cyclo { ?6 ) - a - D having a skin - turnover- improving action distinctly improve glucopyranosyl -( 1 - 4 )- a - D - glucopyranosyl- 1( 6 ) -a - D the skin - turnover- improving action , anti- wrinkle action , glucopyranosyl- (1 4 ) - a - D - glucopyranosyl- ( 1 } anti - fine -wrinkle action , skin -whitening action , anti -blemish disclosed in Japanese Patent Kokai No . 2005 - 95148 , pullu action , and anti -sagging action of the composition , far 25 lan , isomerized sugars , and xylitylglucoside ; amino acids exceeding the additive effects thereof. such as valine , leucine , isoleucine , threonine , methionine , B . Base Skin Cares phenylalanine , tryptophan , lysine , glycine , alanine , aspara The external dermal composition of the present invention gine , glutamine , serine , cysteine , cystine, tyrosine, proline , can be suitably used in the fields of cosmetics such as basic hydroxyproline , asparaginic acid , glutamic acid , sodium skin cares and make - up cosmetics , particularly , outstanding 30 glutamate , hydroxylysine, arginine , ornithine , histidine , and anti - ageing effects thereof can be expected when incorpo - pyrrolidone carbonate ; NMF ingredients (natural moisturiz rated into basic skin cares such as cosmetic lotions , face ing ingredients ) such as sodium lactate , uric acid , and washes, serums, milky lotions, and creams. The following sodium pyrrolidone carbonate ; mucopolysaccharides and are explanations of representative basic skin cares in which their hydrolyzates such as glycogen , dextran , locust bean the external dermal composition of the present invention can 35 gum , xyloglucan , quince seed , carrageenan , pectin , mannan , be incorporated . curdlan , succinoglucan , galactan , arabinogalactan , dermatan < Cosmetic Lotions > sulfate , keratan sulfate , chondroitin , chondroitin sulfate , As described above, the external dermal composition of mucoitinsulfuric acid , keratosulfate , chitin , chitosan , hepa the present invention has an aqueous medium as a base rin , heparan , and hyaluronic acid ; protein and peptides and material that can be made into cosmetic lotions by further 40 their hydrolyzates such as soybean protein degradation incorporating ethanol and humectants . Such cosmetic peptides, wheat protein degradation peptides , hydrolyzed lotions are used for supplementing moisture and moisturiz - wheat proteins , hydrolyzed casein peptides, acyl peptides ing ingredients to the stratum corneum in the skin and to including palmitoyloligopeptide ; silylated peptides, con support the physiological functions in the skin . Concrete chiolin degradation peptides, hydrolyzed conchiolin , pro examples of such cosmetic lotions can be listed as cosmetic 45 teins and peptides such as silk and collagen , hydrolyzates of lotions for washing , astringent cosmetic lotions, softening proteins and peptides such as silk and collagen ; water cosmetic lotions , and multi - layered cosmetic lotions, as well soluble high molecular substances such as hydrolyzed as skin lotions, body lotions, hand lotions, emollient lotions, hyaluronic acid and hydrolyzed eggshell membrane , as well etc. as salts thereof; lecithin derived from soybeans and egg (Humectants ) 50 yolks ; phosphatides and sphingolipids such as phosphatidyl The following can be listed as humectants usable in the glycerol, phosphatidyl inositol , phosphatidyl serine, phos cosmetic lotion according to the present invention : Polyal- phatidyl ethanolamine , phosphatidic acid , and sphingomy cohols such as glycerin , ethylene glycol , propylene glycol, elin ; oils and fats such as Olea europaea ( Olive ) oil , jojoba 1 , 3 -butylene glycol, 3 - methyl- 1 , 3 -butanediol , 1 , 3 -propane oil, and squalane ; silicons such as dimethylpolysiloxane and diol, 2 -methyl - 1, 3 -propanediol , trimethylolpropane, pen - 55 methylphenylsiloxane ; culture supernatants of lactic acid taerythritol, diglycerine , polyglycerine , diethylene glycol, bacteria , bifid bacteria , etc .; and others such as royal jelly triethylene glycol, polyethylene glycol, dipropylene glycol, extract , yeast extract, eggshell membrane protein , bovine polypropylene glycol, 1 , 2 -pentanediol , 1 , 2 -hexanediol , 1 , 2 submaxillary gland mucin , hypotaurine , galactoarabinan , heptanediol , isoprene glycol, isopentyldiol, hexylene glycol, sesame lignan glycosides, albumin , milk whey, choline triglycerine , 2 -methacryloyloxyethyl phosphorylcholine, 60 chloride , phosphorylcholine, placenta extract, coix seed tetrahydrofurfuryl alcohol, polyoxyethylene (POE ) tetrahy extract , Paeonia Suffruticosa root extract , seaweed extract , drofurfuryl alcohol, polyoxypropylene (POP ) butyl ether, Gentiana lutea extract , Saxifraga stolonifera extract , Perilla POP•POE -butyl ether, tripolyoxypropylene glycerin ether, frutescens var. crispa extract, hydrolyzed Oryza sativa [rice ] POP - glycerin ether, POP - glycerin ether phosphate , bran extract , enzymatic decomposition product of prune , POP•POE pentaerythritolether , ethylene 65 trimethylglycine, N -methyl - L - serine, nicotinic -acid amide , glycol propyleneglycol copolymer, phytantriol, and eryth - Scutellaria baicalensis extract, Camellia sinensis var . sin rulose ; glycol alkyl ethers such as ethyleneglycolmonom ensis extract, Centella asiatica extract , Morus bombycis US 10 , 111 , 822 B2 19 20 Koidz. extract, polysaccharides produced from Alcaligenes , side, sodium dl - pyrrolidone carboxylate , L - oxyproline , hydrolyzed Brassica alba extract, sodium acetylhyaluro - acetylglucosamine, and taurine . nate , Althea extract, Japanese angelica extract , Aloe vera Particularly , the following humectants are preferably used extract , Rosa roxburghii roxburghii extract , deoxyribo - in cosmetic lotions incorporated with the external dermal nucleic acid sodium salt, Melothria extract, Daucus carota 5 composition of the present invention because they have an L . extract, Houttuynia cordata extract , oolong tea extract, improved moisturizing effect and more effectively improve wheat germ extract , xylobiose mixture, Akebiae caulis rough skin when used in combination with one or more of L -ascorbic acid , derivatives thereof, and salts thereof; glyc extract, Phellodendoron amurense Ruprecht, Hypericum erin , ethylene glycol, propylene glycol, 1 , 3 - butylene glycol, erectum extract, Pueraria lobata Ohwi, whey , Prunus leaf 10 3 -methyl - 1 , 3 -butanediolo , pentaerythritol, diglycerine , extract, Paeonia extract , great burnet extract, Malpighia polyglycerine , diethylene glycol, triethylene glycol, poly glabra extract, Iris domestica extract, Leontopodium alpi ethylene glycol, dipropylene glycol, trehalose , ceramides num extract, Prunus dulcis extract, glucosylhesperidine , and the like , 2 -methacryloyloxyethyl phosphorylcholine, yellow Himalayan raspberry root extract, peppermint hvaruronic acid , condroitin sulfate , hydrolyzed hvaluronic extract , Rehmannia extract, mevalonolactone, AngelicaAngelica 15 acid , yeast extract , Coix lacryma - jobi var . ma- yuen extract , keiskei extract, Ginkgo biloba extract , Equisetum arvense Paeonia suffruticosa extract, seaweed extract, Gentiana extract, hydrolyzed Glycine max ( L . ) Merrill extract, Thy - lutea extract, trimethylglycine, N -methyl - L -serine , nico mus extract , Coptis extract , adenosine monophosphate , tinic -acid amide , and royal jelly extract, one or more of adenosine triphosphate disodium , dl- a - tocopherol, DL - SO - which can be preferably used as a humectant ( s ) . dium malate , y -amino - 3 - hydroxybutyric acid , Thujopsis 20 The above humectants can be respectively incorporated dolabrata extract, Asparagus officinalis extract, Aspalathus into the cosmetic lotion of the present invention in an linearis extract , Persea americana extract, Prunus arme - amount of at least 0 .0001 % by mass , preferably , 0 .001 to niaca juice, Mytilus glycogen , inositol, Polygonum bistorta 50 % by mass , more preferably , 0 .01 to 25 % by mass, and L . extract , Urtica thunbergiana extract , turmeric extract , uva more preferably , 0 . 1 to 10 % by mass to the mass of the ursi fluidextract, Rosa multiflora fruit extract, Echinacea 25 cosmetic lotion . purpurea leaf extract , ethylglucoside , Lagerstroemia spe- To the cosmetic lotion of the present invention can be ciosa extract, Panax ginseng extract , Ononis extract, Olea incorporated the following : One or more astringents , kera europaea leaf extract, Diospyros kaki Thunberg extract, tinous - layer - softening agents , emollients , and surfactants . Typha latifolia L . extract, Myrciaria dubia extract, Myr - < Astringents > ciaria dubia seed extract, carrot extract, Rubus extract, 30 Examples of the astringents usable in the present inven Actinidia deliciosa extract, Psidium guajava L . extract , tion include : Citric acid , tannic acid , acetoxy propionic acid , Gardenia jasminoides extract, Sasa veitchii extract , Sophora isovaleric acid , aminovaleric acid , ethoxy acetic acid , flavescens extract , glycolic acid , grapefruit extract , Clematis ethoxypropionate , isoaminovaleric acid , epoxyoleic acid , hybrids extract, chlorella extract, Aloe barbadensis Miller elaidic acid , aminobutyric acid , erucic acid , oxaloacetic extract, Geranium thunbergii extract , coffee extract, succinic 35 acid , formic acid , icosanoic acid , glucuronic acid , iduronic acid bis [ 1 - [ 2 - ( 2 -hydroxyethoxy ) ethyl] guanidine - 1 - yl] ester , acid , crotonic acid , chloroisocrotonic acid , isocrotonic acid , hydrolyzed solution of rice bran extract, collagen - tripeptide, acetic acid , dihydrolipoic acid , acidum tartaricum , ethyl extract of root and stem of Asarum heterotropoides var. crotonic acid , diphenylacetic acid , dimethoxyphthalic acid , mandshuricum , succinyl aterocollagen , Crataegus cuneata ethyl hydroxybutyric acid , succinamic acid , stearic acid , extract, Cassia mimosoides L . extract, cyanocobalamin , 40 stealoric acid , sorbic acid , tiglic acid , thyroxin , decanoic seagrass extract , Tilia japonica extract, condensed solution acid , tropic acid , lactic acid , hydroxyisobutyric acid , of dimethylsilanol and hyaruronic acid , Filipendula extract, hydroxyvaleric acid , pyruvic acid , butyl acetate , butylhy Acoraceae root extract, Betula platyphylla extract, silk droperoxide , brassidic acid , propiolic acid , propionic acid , extract , silk powder , Lonicera japonica extract, Averrhoa bromo isovaleric acid , bromoisobutyric acid , bromopropi carambola leaf extract , strawberry fruit juice , Hedera helix 45 onic acid , hexanoic acid , hexenoic acid , petroselinic acid , L . extract, Crataegus laevigata extract, Inula britannica heptadecanoic acid , heptanoic acid , maleanilic acid , extract, Swertia japonica extract , Morus alba L . extract , maleamic acid , mycolic acid , myristic acid , methacrylic sorbitol culture polysaccharide solution , soybean extract, acid , methylvaleric acid , methylthioacetic acid , methyl Ziziphus jujuba extract, Camellia extract , Bellis perennis butyrate ,mevalonic acid , melissic acid , mercaptoacetic acid , extract, Terminalia extract , Rubus suavissimus S . Lee 50 iodoacetic acid , lauric acid , ricinelaidic acid , ricinoleic acid , extract , Prunus persica extract , Picea jezoensis var . hon - linoleic acid , linolenic acid , aconitic acid , oxalosuccinic doensis extract, Zea mays extract, tomato fruit juice , Rosa acid , oxoglutaric acid , adipic acid , calcein , carboxypheny multiflora extract, Hibiscus sabdariffa extract , Lupinus lacetic acid , acetoxysuccinic acid , carbocinchomeronic acid , extract, malt root extract , Alchemilla japonica extract , lactic camphoronic acid , isocamphoronic acid , glutaconic acid , acid bacteria fermented solution of Nelumbo nucifera seed , 55 glutaric acid , isocitric acid , crocetin , succinic acid , phthalic Petroselinum neapolitanum extract , Rosa rugosa extract, acid , fumaric acid , isocinchomeronic acid , diethylenetri Hamamelis japonica extract , rose extract, Parietaria extract , amine pentaacetate , isophthalic acid , citramalic acid , dini Pancratium maritimum extract , Iris domestica extract, Erio - cotinic acid , itaconic acid , dibromosuccinic acid , dichloro botrya japonica leaf extract, phytoglycogen , Aesculus hip - succinic acid , ethylmalonic acid , dimethylsuccinic acid , pocastanum extract, Impatiens balsamina extract, sodium 60 oxalic acid , cinchomeronic acid , hemimellitic acid , pelar polyaspartate solution , Majoranahortensis Moench extract , gonic acid , berberonic acid , benzenehexacarboxylic acid , Lilium extract, Persicaria tinctoria extract with water , Aes - benzenepentacarboxylic acid , maleic acid , malonic acid , culus hippocastanum extract , elastin , natural ceramide mesaconic acid , mesotartaric acid , mesoxalic acid , methyl (types 1 , 2 , 3 , 4 , 5 , and 6 ) , hydroxyceramide , pseudo - isophthalic acid , methylsuccinic acid , methylmalonic acid , ceramide, glycosphingolipid , ceramides including ceramide 65 mercaptosuccinic acid , mellophanic acid , peroxyphthalic and extracts containing ceramide saccharide , deep seawater , acid , malic acid , lutidinic acid , leukotriene bromo anthra alkaline simple hot spring , polyoxyethylene methyl gluco - nilic acid , aminocinnamic acid , isopropyl cinnamic acid , US 10 , 111 , 822 B2 21 22 oxanilic acid , arecaidine, caboxylic cinnamic acid , cinnamic Particularly , in the case of cosmetic lotions into which the acid , gallotannic acid , tranexamic acid , nitrocinnamic acid , external dermal composition of the present invention is hydroxycinnamic acid , methoxycinnamic acid , hydroxyhy - incorporated , preferably used are the following one or more drocinnamic acid , phenylcinnamic acid , ellagic acid , orotic astringents selected from acids such as citric acid , succinic aciduria , camphanic acid , quinic acid , hydroxyproline , etio - 5 acid , acidum tartaricum , retinoic acid , malic acid , retinol, cholanic acid , chaulmoogric acid , carnosine , carbazole ace - zinc chloride , aluminum compounds such as aluminum tic acid , quinolinecarboxylic acid , quinolinic acid , quinoline powder and aluminum sulfate ; alum ; and others such as dicarboxylic acid , coumaric acid , chlorophenoxyacetic acid , denatured alcohol, ethanol, althea extract, arnica extract, chenodeoxycholic acid , cholanic acid , cholic acid , san - Polygonum extract, Urtica dioica L . extract, Iris sanguinea toninic acid , dihydro ortho acid , succinuric acid , thiophen - 10 Hornem extract, Foeniculum vulgare extract, oolong tea carboxylic acid , tetrahydrofolic acid , dehydrocholic acid , extract, ethanol, Lagerstroemia speciosa extract, Hypericum terpenylic acid , hydroxypyrone carboxylic acid , hydroxy - erectum , Citrus aurantium Dulsis (Orange ) flower water , pyrone dicarboxylic acid , hydroxyphenylacetic acid , orange juice , Artemisia capillaris extract, strawberry hydroxyphenylpropionic acid , phenyldicarboxylic acid , extract , Psidium guajava L . extract, Ribes nigrum fruit homogentisic acid , mandelic acid , muricholic acid , methyl- 15 extract, geraniol, Geranium thunbergii extract , Crataegus dopa , methylphenylacetic acid , methylfurancarboxylic acid , cuneata extract, Filipendula multijuga extract, Paeonia lac methyl red , mefenamic acid , lysergic acid , lithocholic acid , tiflora extract, Betula platyphylla extract, Lonicera japonica lipoic acid , reserpinic acid , retinoic acid , levopimaric acid , extract , Equisetum arvense extract, Hedera helix L . , Cra glycolic acid , salicylic acid , paraphenol zinc phenolsul taegus laevigata extract, Thymus extract, Camellia sinensis fonate ; extracts of plants such as Althea officinalis , Arnica 20 extract, Houttuynia cordata extract, Petroselinum neapoli montana , Polygonum bistorta , Iris spp ., Foeniculum vul- tanum extract, Hamamelis virginiana extract, Vitis spp . leaf gare , Lagerstroemia speciosa, Citrus sinensis , Rubus L ., extract , Pinus extract, Melissa Officinalis leaf extract , Cen Psidium guajava L . , Ribes nigrum , Geranium thunbergii, taurea cyanus extract, Artemisia indica var. maximowiczii Crataegus cuneata , Filipendula multijuga , Paeonia lacti - extract, Citrus limon juice, Astragalus sinicus extract, and flora , Betula platyphylla var. japonica , Lonicera japonica , 25 Sanguisorba officinalis extract . Equisetum arvense , Hedera helix , Thymus vulgaris , Camel- Examples of the keratinous- layer - softening agents , pref lia sinensis, Petroselinum crispum , Hamamelis virginiana , erably used are the following one or more ingredients Vitis spp . , Centaurea cyanus, Citrus limon , Astragalus sini- selected from ethanol, isopropyl alcohol, propanol, butanol, cus , Sanguisorba officinalis , Cinchona succirubra , Salvia polyethylene glycol, benzyl alcohol, phenylethyl alcohol, L ., Tilia miqueliana , Panax ginseng [ Asian ginseng ], Juni- 30 propylene carbonate, hexyl dodecanol, dimethylsulfoxide , perus communis , Rosmarinus officinalis L . , Hypericum erec - dimethylacetamide , dimethylformamide , triethanolamine , tum , Ginkgo biloba , Melissa officinalis , Ononis spinosa diisopropyl adipate , ethyl laureate , lanolin , dialkylolamides Linn , Aesculus hippocastanum , Swertia japonica , Allium of fatty acids , urea , sulfur, resorcin , phytic acid , lactic acid , sativum , Matricaria recutita , Thymus vulgaris, Mentha lactate , glycolic acid , sodium hydroxide , etc . Particularly , in arvensis var. piperascens, Urtica thunbergiana , Capsicum 35 the case of cosmetic lotions into which the external dermal annuum L ., Zingiber officinale , Humulus lupulus, Aesculus composition of the present invention is incorporated , one or hippocastanum , Lavandula angustifolia , Daucus carota more of ingredients selected from urea , sulfur, ethanol, lactic subsp . sativus, Brassica juncea , Cinnamomum cassia Bi. , acid , glycolic acid , salicylic acid , and sodium sulfate , which Pinus, Cnidium officinale Makino , Sambucus sieboldiana , are superior in keratinous - layer - softening effect. Ostericum sieboldii, Scopolia japonica , Paeonia suffruti - 40 (Emollients ) cosa , Myrica rubra , Houttuynia cordata , Nuphar japoni- Oily ingredients, which are close to sebum , are mainly cum , Diospyros spp ., Calendula officinalis, Papaver rhoeas preferable as the emollients [ softeners ] and exemplified as L ., Gentiana scabra var. buergeri, Glehnia littoralis , Citrus follows: Plant and animal oils and fats such as Cannabis aurantium , Citrus junos, Acorus calamus, Citrus natsu seed oil , Astrocaryum yauaperyense fat, Brassica campes daidai, Melilotus officinalis , Zanthoxylum piperitum , Euca - 45 tris seed oil , African Mango kernel oil , Prunus armeniaca lyptus globulus, Artemisia indica var . maximowiczii , Rab - kernel oil , Camelina seed oil , Argania spinosa kernel oil , dosia japonica , Oryza sativa, Sophora flavescens, Zingiber Prunus armeniaca kernel oil, Hippophae rhamnoides oil , officinale , Eugenia caryophyllata , leaf of Juglans, Scutel- Echium plantagineum seed oil , emu oil, orange roughy oil , laria baicalensis , Salvia officinalis , Rosmarinus officinalis canola oil, Torreya nucifera seed oil , Garcinia indica Choisy L . , Polygonum multiflorum Thunb . , Coptis japonica 50 seed oil, Carum carvi seed oil, Prunus armeniaca L . var ( Thunb . ) Makino , Phellodendron amurense Rupr. , Scutel- anus Maxim oil , Aleurites moluccana oil , Crambe abyssi laria baicalensis Georgi, Houttuynia cordata , Aurantii nobi- nica seed oil containing erucic acid , Vaccinium macrocar lis pericarpium , Daucus carota subsp . sativus, Juncus effu - pon seed oil, walnut seed oil, Ribes nigrum seed oil , Vac sus L . var decipiens Buch , and Alisma rhizome; plant cinium vitis - idaea L . seed oil, rice germ oil, Pinus parviflora extracts of tannin and tar of Betula platyphylla ; propolis , 55 seed oil, Camellia sasanqua oil , Shorea seed oil , oxidized royal jelly , yeast extract, tuberosa polysaccharide solution , corn oil, shea oil and fat , Shorea stenoptera ( seed ) butler, oolong tea , alum , zinc chloride , zinc sulfate , aluminum Lupinus albus seed oil, hydrogenated avocado oil , hydro sulfate , aluminum chloride , aluminum chloride hydroxide genated olive oil, hydrogenated beef tallow , hydrogenated allantoin , dihydroxyaluminum allantoin , aluminum soybean oil , hydrogenated jojoba oil , hydrogenated veg hydroxychloride , zinc oxide , zinc sulfide , zinc sulfocarbo - 60 etable oil, hydrogenated palm kernel oil , hydrogenated palm late , sodium sulfocarbolate , and organic composites of alu - oil , castor oil hydrogenated , hydrogenated jojoba oil, hydro minum or zirconium . genated vegetable oil, hydrogenated coconut oil, Sclero Usually, the above astringents can be respectively incorncor carya birrea seed oil, Struthio camelus oil , Passiflorae porated into the cosmetic lotion of the present invention in incarnata L . seed oil , Camellia sinensis oil , camellia oil, an amount of at least 0 . 0001 % by mass , preferably , 0 . 001 to 65 Vaccinium oxycoccos seed oil, Theobroma grandiflorum 50 parts by mass , more preferably , 0 .01 to 25 % by mass , and seed fat, lard , creams, Coix lachryma - jobi L . var. ma -yuen more preferably , 0 . 1 to 10 % by mass. Stapf Coix oil, babassu oil, peanut oil , Pistachio seed oil , US 10 , 111 , 822 B2 23 24 Hippophae rhamnoides oil , sunflower seed oil, Vaccinium sucrose acetate isobutyrate , caprylyl eicosenoate , butyl ethyl myrtillus L . seed oil , grape seed oil, partially hydrogenated propanediol ethylhexanoate , octyldodecyl erucate , oleyl eru perilla oil , partially hydrogenated hourse oil , prune seed oil , cate , alkyl octanoate (C14 , C16 , and C18 ), (octanoicacid / broccoli seed oil, Luffa cylindrica seed oil, Cucurbita pepo stearicacid / adipic acid ) glyceryl, cetyl octanoate , stearyl Linnaeus seed oil, Haematococcus pluvialis oil , Rubus 5 octanoate , cetearyl ethylhexanoate , hexyldecyl ethylhexano chamaemorus seed oil , pine seed oil, Mangifera indica seed ate , ethyl olivate , oleyl oleate , caprylic /capric glycerides, fat, Mangifera indica seed oil, mink oil, Melia azadirachta caprylic /capric / coconut fatty acid glyceride , caprylic /capric / seed oil , peach kernel oil, begetable oil, Camellia oleifera succinic triglyceride, cetyl caprate , triisostearyl citrate , tri oil, Rubus idaeus seed oil , apple seed oil , Borago officinalis isooctyldodecyl citrate , citric / lactic / linoleic /oleic tetraglyc seed oil, rose hip oil, seed oil of Moringa oleifera Lam ., 10 eride, isostearyldiglyceryl succinate , diethoxylethyl Macadamia integrifolia oil , castor oil , olive oil , almond oil, succinate , dioctyl succinate , phytosteryl rice bran oil fatty cacao oil, camellia oil , coconut oil, palm oil , tallow , jojoba acid , cetyl acetate , farnesyl acetate, lanolin alcohol acetate , oil , grape seed oil , avocado oil , safflower oil, sesame oil, linalyl acetate , propylene glycol diisostearate , dimer - dilino Camellia sinensis oil, evening primrose oil , wheat germ oil, leyl diisostearate , dimer- dilinoleyl diisostearate, neopentyl hazelnut oil, Limnanthes alba oil, Prumus persica kernel oil, 15 glycol diisostearate , neopentyl glycol diethylhexanoate , peppermint oil, Melaleuca alternifolia oil, corn oil , canola PEG -18 castor oil dioleate , di- ( caprylic acid /capric acid ) oil , sunflower oil , linseed oil, cotton oil , soybean oil, peanut butylene glycol, isosorbide dicaprylate , di- ( caprylic acid / oil , rice bran oil, cacao oil , shea oil , fennel oil , perilla oil, capric acid ) polyethylene glycol, dicocoyl pentaerythrityl chamomile oil , carrot oil, cucumber oil , egg yolk oil , beef distearyl citrate , polyethylene glycol distearate , PG - 20 fat , hourse fat , fish oil , turtle oil , and orange roughy oil ; 20 methylglucose distearate, pentaerythrityl distearate , diethyl waxes such as lacquer - tree fruit rind wax , Jasminum offici- pentanediol dineopentanoate, methyl pentanediol dineopen nale flower wax , orange fruit rind wax , orange flower wax , tanoate , polyethylene glycol dinonanoate , C10 - 30 choles hydrpogenated jojoba oil ester, carnauba wax , candelilla terol/ lanosterol esters, C12 - to C - 18 cetyl esters , glycol wax , Narcissus poeticus L . flower wax , rice bran wax , dilaurate , diisopropyl dimer dilinoleate, pentaerythrityl Myrica rubra f . alba fruit wax , sweet acacia flower wax , 25 hydrogenated rodinate , methyl hydrogenated rosinate , glyc Polianthes tuberosa flower wax , beeswax, spermaceti , eryl diisostearate / hydrogenated rosinate , ethylhexyl stear orange roughy oil, lanolin , rice wax , montan wax , and ate , isocetyl stearoyl oxystearate , octyldodecyl stearoyl ozokerite ; hydrocarbons such as isoeicosane , isododecane , oxystearate , dibutyloctyl sebacate , octyldodecyl/ PPG - 3 isohexadecane , diethylhexylcyclohexane , pentahy . myristyl ether dimer dilinoreate , di - ( isostearyl/ phytophyto drosqualane , mineral oils , petrolatum , polyisobutene , hydro - 30 ryl) dimer dilinoleate, dicetearyl dimer dilinoleate , hydro genated polyisobutene , polybutene, squalane , squalene , genated castor oil dimer dilinoleate , stearyl/ PPG - 3 myristyl microcrystalline wax , ceresin wax , paraffin wax , vaseline , ether dimer dilinoleate , dimer dilinoleyl dimer dilinoleate , ozokerite , a - olefin oligomer , and tetradecene ; natural and bis - behenyl/ isostearyl / phytosteryl dimer dilinoleyl dimer synthetic fatty acids and salts thereof such as isomerized dilinoleate , phyto phytosteryl/ isostearyl / cetyl/ stearyl/ behe linoleic acid , tallowate , fatty acids (C14 - 28 ) , fatty acids 35 nyl dimer dilinoleate , dimer dilinoleyl hydrogenated rosin (C20 -40 ), hydrogenated coconut fatty acid , palm kernel fatty condensate , C14 - 15 dialkyl carbonates, diethylhexyl car acid , 10 -hydroxydecanoic acid , branched fatty acids (C14 bonate , dicaprylyl carbonate , pentaerythrityl tetraisostear 28 ), branched fatty acids (C21 -31 ), behenic acid , capric a te, pentaerythrityl tetraoctanoate , polyglyceryl- 10 dodeca acid , myristic acid , palmitic acid , stearic acid , behenic acid , caprylate /caprate , diisocetyl dodecanedioate , dioctyldodecyl lanolin fatty acid , linoleic acid , linolenic acid , lauric acid , 40 dodecanedioate , triisostearate , erythrityl triethylhexanoate , oleic acid , isostearic acid , undecylenic acid , 1 , 2 - hydrox ditrimethylolpropane triethylhexanoate , triethylhexanoin ystearic acid , palmitooleic acid , erucic acid , docosahexae - ( trioctanoin ) , trimethylolpropane tiethylhexylhexanoate noic acid , eicosapentaenoic acid , isohexadecenoic acid , trimethylolpropane, tricaprylin , caprylic /capric triglyceride, anteisoheneicosanoic acid , isononanoic acid , and 2 - ethyl - caprylic / capric / stearic triglyceride , caprylic / capric /myristic / hexanoic acid , natural and synthetic higher alcohols such as 45 stearic triglyceride , C8 - 12 acid - triglycerides , tristearin , tri C12 - 16 alcohols , C14 - 22 alcohols , C20 -22 alcohols , C20 -40 palmitin , tripalmitolein , trihydroxystearin , tribehenate , alcohols , C30 - 50 alcohols, brassica rapeseed sterol, isocetyl dipentaerythrityl tri -polyhydroxystearate , trimyristin , C12 alcohol, isopropanol, caprylyl glycol, rice bran sterol, hydro - 15 alkyl lactates, ethyl lactate , octyldodecyl lactate , butyl genated rapeseed alcohol, cetanol, stearyl alcohol, hexyl lactate , menthyl lactate , isodecyl neopentanoate , myristyl decanol, octyl dodecanol, lauryl alcohol, capryl alcohol, 50 neopentanoate , nonanoic acid octyl ester , nonanoic acid myristyl alcohol, oleyl alcohol, cetostearyl alcohol, arachyl cholesterol ester, ethylhexyl palmitate , cetyl palmitate , bis alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, diglyceryl polyacyladipate - 1 , bis - diglyceryl polyacyladi selachyl alcohol, batyl alcohol, isostearyl alcohol, cetyl pate - 2 , dipentaerythrityl pentahydroxystearate / pentaisoste alcohol, cholesterol, phytosterol, lanolin alcohol, hydroge arate , ethylhexyl dihydroxystearate , octyl hydroxystearate , nated lanolin alcohol, palmityl alcohol, and 2 -decyltetrade - 55 hydrogenated castor oil hydroxystearate, dipentaerythrityl cinol; esters such as isopropyl C12 - 15 -pareth - 9 carboxylate , hexahyroxystearate /stearate /rosinate , phytosteryl hydrox octyldodecyl pyrrolidone carboxylic acid , menthyl pyrroli ystearate , PPG -6 castorate , methyl ricinoleate , myristyl pro done carboxylic acid , lauryl pyrrolidone carboxylic acid , pionate , C10 - 40 isoalkyl acid cholesterol esters, dipen PEG - 2 isosedes - 7 carboxylic acid cetyl ester, di- PPG - 3 taerythrityl hexahydroxystearate , dipentaerythrityl myristyl ether adipate , di- PPG - 2 myreth - 10 adipate , diiso - 60 hexahydroxystearate /hexastearate /hexarosinate , stearyl hep propyl adipate , diheptylundecyl adipate , ethyl avocadate , tanoate , glyceryl behenate / eicosadioate , jojoba esters , iso butyl avocadate , methyl gluceth - 20 benzoate , ethyl isoste - propyl jojobate , ethyl macadamiate , cholesteryl macadami arate , ( isostearic acid /succinic acid ) castor oil , hydrogenated ate , phytosteryl macadamiate , dioctyl maleate , diethylhexyl castor oil isostearate, batyl isostearate , hexyldecyl isostear - syringylidenemalonate , heyldecyl myristoyl methylamino ate , ( isostearic acid /bees wax /succinic acid ) castor oil, iso - 65 propionate , citronellyl methylcrotonate , medowfoam decyl isononanoate , isotridecyl isononanoate , isononyl e stolide , octyldodecyl meadowfoamate , glyceryl cocoate / isononanoate , octyl isononanoate , cetearyl isononanoate , citrate / lactate , decyl cocoate , cholesteryl butyrate , dihydro US 10 , 111 , 822 B2 25 26 cholesteryl butyrate , octyldodecyl lanolate , cholesteryl lano - oleyl alcohol, behenyl alcohol, lanolin alcohol, hydroge late, octyldodecyl ricinoleate , diethylhexyl malate , trioleyl nated lanolin alcohol, hexyldecanol, octyldodecanol, phosphate , tricetyl phosphate , glyceryl tri - 2 -ethylhexanoate , squalane , plant squalane, cetyl 2 - ethylhexanoate, a - olefin cetyl 2 -ethylhexanoate , neopentyl glycol di- 2 - ethylhexano oligomer , isotridecyl isononanoate , isononyl isononanoate , atte , isopropyl myristate , butyl myristate , isopropyl palmi- 5 cetearyl isononanoate , ethyl oleate , oleyl oleate , ethylhexyl tate , ethyl stearate , octylpalmitate , isocetyl isostearate , butyl palmitate , caprylyl glycol, and hydrogenated soybean phos stearate , ethyl linoleate , isopropyl linoleate , ethyl oleate , pholipid . isocetyl myristate , isostearylmyristate , isostearyl palmitate , < Surfactants > octyldodecyl myristate , diethyl sebacate, diisopropyl adi Examples of the surfactants are as follows: Sorbitan pate , isoalkyl neopentanoate , caprylic /capric triglyceride , 10 monolaurate , coconut oil fatty acid sorbitan , sorbitan dis trimethylolpropane tri- 2 - ethylhexanoate , trimethylolpro - tearate , sorbitan monostearate , sorbitan tristearate , sorbitan pane triisostearate , pentaerythritol tetra - 2 - ethylhexanoate , monoisostearate, sorbitan monooleate , sorbitan trioleate , cetyl caprylate , decyl laurate , hexyl laurate , decyl myristate , sorbitan fatty acid ester , sorbitan monopalmitate , sorbitan myristyl myristate , cetyl myristate , glyceryl trimyristate , sesquioleate , sorbitan sesquistearate, polyoxyethylene sor stearyl stearate , decyl Oleate , cetyl ricinoleate, isostearyl 15 bitan monolaurate , polyoxyethylene sorbitan monostearate , laurate , isotridecylmyristate , isocetyl palmitate , octyl stear ethylene glycol monostearate , ethylene glycol distearate , ate , isocetyl stearate , isodecyl oleate , octyldodecyl Oleate , diethylene glycol distearate , ethylene glycol fatty acid ester, octyldodecyl linoleate , isopropyl isostearate , cetostearyl glyceridemonostearate , glyceride distearate , glyceryl isoste 2 - ethylhexanoate , stearyl 2 - ethylhexanoate , hexyl isostear arate , polyoxyethylene glyceryl isostearate, polyoxyethyl ate , ethylene glycol dioctanoate , ethylene glycol diloleate , 20 ene glyceryl triisostearate , diglyceryl isostearate , glyceryl propylene glycol dioleate , propylene glycol dicaprate, pro - diisostearate , glyceryl triisostearate , diglyceryl triisostear pylene glycol dicaprylate/ dicaprate , caprylic /capric triglyc ate , propylene glycol monostearate , self -emulsifying pro eride , propylene glycol dicaprylate , neopentyl glycol pylene glycol stearate , glyceryl ricinoleate , propylene glycol dicaprate , neopentyl glycol dioctanoate , glyceryl tricapry ricinoleate , propylene glycol fatty acid ester, propylene late, glyceryl triundecylate , glyceryl triisopalmitate , glyc - 25 glycol dioleate , propylene glycol laurate , glyceryl linoleate , eryl triisostearate, octyldodecyl neodecanoate , octyldodecyl g lyceryl diisopalmitate , glyceryl sesquioleate , glyceryl neopentanoate , isostearyl octanoate , hexyldecyl neodecanene , monooleate , glyceryl trimyristate , isopropyl lanolate , hex hexyldecyl neodecanoate , octyldodecyl neodecanoate , yldecyl dimethyl octanoate , aceto glyceryl, glyceryl tri isostearyl isostearate , octyldecyl isostearate , polyglyceryl isooctanoate , glyceryl di- 2 -heptylundecanoate , glyceryl oleate ester , polyglyceryl isostearate ester, dipropyl carbon - 30 monopyroglutamate monooleate , decaglyceryl decaoleate , ate , C12 - to C18 - dialkyl- carbonates , triisocetyl citrate , tri- dipentaerythrite fatty acid ester, glyceryl stearate /malate , isoarachidyl citrate , triisooctyl citrate , lauryl lactate ,myri polyoxyethylene hydrogenated castor oil, polyoxyethylene styl lactate , cetyl lactate , octyldecyl lactate , lanolin lactate , alkyl ( 12 - 14 ) ether (7E .O .) , polyoxyethylene alkyl (12 - 14 ) triethyl citrate , acetyltriethyl citrate , acetyltributyl citrate , ether ( 12E . O .) , polyoxyethylene alkyl ether ( 20E . O . ), poly trioctyl citrate , diisostearyl malate , 2 - ethylhexyl hydrox - 35 oxyethylene lauryl ether, polyoxyethylene myristyl ether , ystearate , 2 - ethylhexyl succinate , diisobutyl adipate , diiso polyoxyethylene cetyl ether , polyoxyethylene cetostearyl propyl sebacate , dioctyl sebacate , cholesteryl stearate , cho ether, polyoxyethyl stearyl ether, polyoxyethylene oleyl lesteryl isostearate , cholesteryl hydroxystearate , cholesteryl ether , polyoxyethylene oleyl cetyl ether , polyoxyethylene oleate , dihydrocholesteryl oleate , phytosteryl isostearate , behenyl ether , polyoxyethylene octylphenyl ether, polyoxy phytosteryl Oleate , isocetyl 12 - stearoyl hydroxystearate , 40 ethylene nonylphenyl ether, polyoxyethylene alkyl ( 12 ,13 ) stearyl 12 -stearoyl hydroxystearate , isostearyl 12 - stearoyl ether ( 10E . O . ), polyoxyethylene octyldodecyl ether , poly hydroxystearate , hexyldecyl dimethyloctanoate , and isopro - oxyethylene cetyl stearyl diether , polyoxyethylene methyl pyl lanolate ; lanolins such as liquid lanolin , hydrogenated glucoside sesquistearate , carboxylated polyoxyethylene tri lanolin , adsorption refined lanolin , lanolin acetate , acety - decyl ether, mixture of polyethylene glycol- 4 octanoate and lated lanolin , hydroxylanolin , polyoxyethylene lanolin , hard 45 poly (oxyethylene )nonylphenyl ether ( 14E . O . ) , polyoxyeth lanolin fatty acid , and cetyl•lanolyl acetate ; sphingophos - ylene lanoline alcohol, polyoxyethylene (5 ) lanoline alco pholipids such as lecithin , phosphatidylcholine , phosphati - hol , polyoxyethylene ( 10 ) lanoline alcohol, polyoxyethylene dylethanolamine , phosphatidylserine , phosphatidylglycerol, ( 15 ) lanoline alcohol, polyoxyethylene ( 20 ) lanoline alco phosphatidylinositol, and sphingomyelin ; phospholipids hol , polyoxyethylene ( 25 ) lanoline alcohol, polyoxyethylene such as phosphatidic acid and lysolecithin ; phospholipid 50 (40 ) lanoline alcohol, polyoxyethylene (alkylol / lanolin alco derivatives such as hydrogenated soybean phospholipid , hol )ether ( 16E . O . ), polyoxyethylene lanolin alcohol acetate , partially hydrogenated soybean phospholipid , hydrogenated polyoxyethylene lanolin , polyoxyethylene hydrogenated egg yolk - phospholipid , and partially hydrogenated egg yolk - lanolin , polyoxyethylene sorbitol lanolin (40E . O . ), polyoxy phospholipids; sterols such as dihydrocholesterol, lanos ethylene polyoxypropylene hydrogenated lanolin , polyoxy terol, dihydrolanosterol , and cholic acid ; silicon -containing 55 ethylene polyoxypropylene lanolin , polyoxyethylene poly oil agents such as methylphenylpolysiloxane , methylhydro oxypropylene lanolin oil , polyoxyethylene stearic acid gen polysiloxane, octamethylcyclotetrasiloxane , stearoxy - amide , polyoxyethylene phytosterol, polyoxyethylene silicone , decamethylcyclopentasiloxane, and dodecamethyl dinonylphenyl ether, polyethylene glycol monolaurate , cyclohexasiloxane; sapogenins; saponins; and fluorine -con - polyethylene glycol dilaurate , polyethylene glycol palmi taining oil agents such as perfluoropolyether, perfluorodeca - 60 tate , polyethylene glycol dipalmiate , polyethylene glycol lin , and perfluorooctane . dipalmiate , polyethylene glycol monooleate , polyethylene Particularly, in the case of cosmetic lotions in which the glycol 150 dioleate , polyethylene glycol monostearate, poly external dermal composition of the present invention is ethylene glycol distearate , polyoxyethylene glyceryl tristear incorporated , the following one or more emollient agents , ate , polyethylene glycol 300 lanolin fatty acid , polyethylene which are advantageous in emollient effect and widely used 65 glycol 600 lanolin fatty acid , polyethylene glycol 1000 in a cosmetic field , can be preferably used in combination ; lanolin fatty acid , polypropylene glycol (36 ) monooleate , cetanol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, polyoxyethylene ( 20E . O . ) sorbitan monolaurate , polyoxy US 10 , 111, 822 B2 27 28 ethylene ( 20E . O . ) coconut oil fatty acid sorbitan , polyoxy - rityl rosinate , hexaglyceryl oleate , methyl glucose sesqui ethylene (20E . O . ) sorbitan monopalmitate , polyoxyethylene stearate , polyethylene glycol monooleate , polyethylene (40E .O .) sorbitan oleate , polyoxyethylene (6E .O .) sorbitan glycol alkylate , polyethylene alkyl ether, polyglycol diether, monooleate , polyoxyethylene (20E .O .) sorbitan lauroyl diethanolamide, fatty acid isopropanolamide , malti monooleate , polyoxyethylene Sorbitan monolaurate , poly - 5 tol hydroxy fatty acid ether , alkylated polysaccharide , alky oxyethylene sorbitan tetraoleate , polyoxyethylene ( 20E . O . ) lglucoside; trehalose mono - fatty acid ethers such as treha sorbitan trioleate , polyoxyethylene (6E . O . ) sorbitan monos - lose monomyristate , trehalose monoisostearate, and tearate , polyoxyethylene ( 20E . O . ) sorbitan monostearate , trehalose monoundecylate ; polyoxyethylene methyl gluco polyoxyethylene (6E . O . ) sorbitan tristearate , polyoxyethyl- side dioleate ( 120E . O . ) ; sugar esters such as sucrose fatty ene sorbitan hexastearate , polyoxyethylene (3E . O . ) sorbitan 10 acid ester and glyceryl cocoate ; non - ionic surfactants such isostearate , polyoxyethylene glyceryl monostearate , sor as lipophilic glycerin monostearate , self - emulsifying glyc beth - 6 beeswax , polyoxyethylene polyoxypropyl ene butyl eryl monostearate , polyglyceryl monostearate , polyglyceryl ether, polyoxyethylene (20 ) polyoxypropylene ( 15 ) butyl alkylate , sorbitanmonooleate , polyethylene glycol monoste ether , polyoxyethylene (35 ) polyoxypropylene (28 ) butyl arate , polyoxyethylene sorbitan monooleate , polyoxyethyl ether , polyoxyethylene ( 36 ) polyoxypropylene (36 ) butyl 15 ated sterol, polyoxyethylated lanolin , polyoxyethylated ether , polyoxyethylene (37 ) polyoxypropylene (38 ) butyl beeswax , polyoxyethylene hydrogenated castor oil , glycerin ether , polyoxyethylene polyoxypropylene cetyl ether , poly fatty acid ester, polyglycerin fatty acid ester, POE sorbitan oxyethylene polyoxypropylene decyltetradecyl ether , poly - fatty acid ester, POE sorbit fatty acid ester, POE glycerin oxyethylene polyoxypropylene oligo succinate (3E . O . ) fatty acid ester, POE alkyl ether, POE fatty acid ester, POE ( 20P. O . ) , polyoxyethylene polyoxypropylene hexylene gly - 20 hydrogenated castor oil, POE castor oil, POE•POP copoly col ether (300E . O . ) ( 75P . O . ) , trimethylolpropane tri (poly - mer , POE•POP alkyl ether, polyether -modified silicone lau oxyethylene isostearate ) ( 3E . O . ), glyceryl polyoxyethylene ric acid alkanolamide , alkylamineoxide, hydrogenated soy oleate , polyoxyethylene ( 10 ) polyoxypropylene glycol ( 30 ), bean phospholipid , caprylyl glucoside, glycerol citric acid polyoxyethylene ( 16 ) polyoxypropylene glycol (30 ), poly - fatty acid ester , glyceryl stearate citrate , corn oil PEG - 8 oxyethylene ( 25 ) polyoxypropylene glycol (30 ) , polyoxy - 25 esters , cocamide DEA , cocamide MEA , Cocamide MIPA , ethylene ( 160) polyoxypropylene glycol (30 ) , polyoxyeth - sucrose tetrastearate triacetate , hydrogenated palm kernel ylene ( 30 ) polyoxypropylene glycol (35 ), polyoxyethylene glycerides, hydrogenated palm PEG - 200 glyceride, hydro ( 200 ) polyoxypropylene glycol (40 ) , polyoxyethylene ( 200 ) genated palm glycerides, sorbitan sesquiisostearate , polyoxypropylene glycol (70 ) , polyoxyethylene (20 ) poly polyglyceryl- 2 sesquiisostearate , polyglyceryl- 2 sesqui oxypropylene glycol ( 15) butyl ether , polyoxyethylene (6 ) 30 caprylate , and PEG - 20 methyl glucose sesquistearate ; anion polyoxypropylene glycol (30 ) , polyoxyethylene ( 1 ) poly - surfactants such as sodium stearate , zinc stearate , calcium oxypropylene ( 4 ) cetyl ether , polyoxyethylene ( 1 ) polyoxy - stearate , magnesium stearate , aluminum stearate , aluminum propylene ( 8 ) cetyl ether, polyoxyethylene ( 20 ) polyoxypro - isostearate , triethanolamine stearate , potassium palmitate , pylene ( 4 ) cetyl ether, polyoxyethylene (20 ) sodium cetyl sulfate , sodium lauryl phosphate, disodium polyoxypropylene ( 8 ) cetyl ether , polyoxypropylene ( 9 ) 35 lauryl phosphate , triethanolamine palmitate , sodium poly diglyceryl ether , polyoxypropylene stearyl ether , tetra (poly - oxyethylene lauryl phosphate , sodium N -acylglutamate , oxyethylene polyoxypropylene )ethylenediamine , polyoxy - sodium palmitate , sodium laurate , potassium laurate , zinc ethylene (6E . O . ) capric /caprylic glyceride , polyoxyethylene laurate , triethanolamine laurate , sodium laureate , sodium glyceryl laurate , polyoxyethylene glyceryl coconut oil fatty lauryl sulfate , potassium lauryl sulfate , ammonium lauryl acid , polyoxyethylene diethanolamine lauric acid ester 40 sulfate , monoethanolamine lauryl sulfate , diethanolamine ( 4E . O . ) , dioctyldodecyl lauroyl glutamate , dipolyoxyethyl- lauryl sulfate, triethanolamine lauryl sulfate , sodium lauryl ene stearyl ether diester lauroyl glutamate , polyoxyethylene diaminoethyl glycine , triethanolamine ether alkyl sulfate , octyldodecyl ether diester lauroyl glutamate , polyoxyethyl- turkey red oil , linear dodecyl benzene sulfonate , polyoxy ene glyceryl pyroglutamic acid isostearate , PEG -40 hydro - ethylene hydrogenated castor oil maleate , acyl methyl tau genated castor oil PCA isostearate , capric acid dietha - 45 rate , fatty acid soap , a - acylsulfonate , alkyl sulfonate , alkyl nolamine , undecylenic acid monoethanolamide , coconut oil allyl sulfonate , alkyl naphthalene sulfonate , alkyl sulfate , fatty acid monoethanolamide , coconut oil fatty acid dietha - POE alkyl ether sulfate , alkyl amide sulfate , alkyl phos nolamide ( 1 : 2 type ) , coconut oil fatty acid diethanolamide , phate , POE alkyl phosphate , alkyl amide phosphate , alky lauric acid ethanolamide , lauric acid diethanolamide , lauric loyl alkyl taurate , N - acyl amino acid salt, POE alkyl ether acid isopropanolamide , lauramide/ myristamide diethanol- 50 carbonate , alkylsulfo succinate , sodium alkyl sulfoacetate , amide (DEA ), lauramide /myristamide triethanolamine acyl isethionate , acylated hydrogenated collagen peptide ( TEA ), myristic acid diethanolamide , palmitic acid ethano - salt, perfluoroalkyl phosphate , soap noodle , potash soap , lamide , stearic acid monoethanolamide , stearic acid dietha - zinc undecylenate , soap noodle containing potassium , potas nolamide , stearic acid diethylaminoethylamide , isostearic sium coconut oil fatty acid , sulfonated castor oil , sodium acid diethanolamide , oleic acid diethanolamide , linoleic acid 55 myristate , potassium myristate , zinc myristate , magnesium diethanolamide , tallowamide monoethanolamide , tallow myristate , sodium oleate , potassium oleate, N - acyl- L - gluta amide diethanolamide, hydrogenated tallowamide diethano - mic acid triethanolamine , sodium N - acyl- L - glutamate , lamide , lanolinamide diethylamide , polyoxyethylene coco sodium N -coconut oil fatty acid acyl- L - glutamate , sodium nut oil fatty acid amide (5E . O .) , polyoxyethylene ( 2 ) N -coconut oil fatty acid /hydrogenated tallowate acyl- L coconut oil fatty acid monoethanolamide , polyoxyethylene 60 glutamate , N - coconut oil fatty acid acyl- L - glutamic acid ( 5 ) coconut oil fatty acid monoethanolamide , polyoxyeth - triethanolamine , di sodium stearoyl- L - glutamate, sodium ylene ( 10 ) coconut oil fatty acid monoethanolamide , poly - N -hydrogenated tallowate acyl- L - glutamate , sodium N -lau oxyethylene coconut oil fatty acid diethanolamide, polyoxy - royl- L -glutamate , N - stearoyl- L - glutamate , N - lauroyl- L - ly ethylene beef tallow alkyl diethanolamine (2E . 0 . ), sine , lauroyl- L - glutamic acid triethanolamine, L - arginine polyoxyethylene coconut oil alkyl dimethylamineoxide, 65 ethyl•DL -pyrrolidone carboxylic acid salt, N -coconut oil coconut oil alkyl dimethylamine oxide liquid , oleyldimeth - fatty acid acyl- L -arginine ethyl•DL - pyrrolidone carbonate , ylamine oxide, dihydroxyethyl lauramine oxide, pentaeryth cocoyl sarcosinate, sodium cocoyl sarcosinate , N - ( cocoyl) US 10 , 111, 822 B2 29 30 sarcosine triethanolamine salt, lauroyl sarcosine, sodium triethanolamin alkyl ( 12 - 15 ) sulfate , triethanolamin alkyl lauroyl sarcosine , lauroyl sarcosine triethanolamine , car ( 12 - 14 ) sulfate , sodium alkyl ( 12 , 13 ) sulfate , triethanolamin boxylated polyoxyethylene tridecyl ether sodium salt polyoxyethylene alkyl ether sulfate ( 3E . O .) solution , sodium ( 3E . O . ) , sodium B - laurylaminopropionate , laurylaminopro C11 - 15 pareth - 3 sulfate , sodium C12 - 13 pareth - 3 sulfate , pionate solution , potassium methyl cocoyl taurate , sodium 5 sodium C12 - 15 pareth - 3 sulfate , TEA C12 - 13 pareth - 3 sul methyl cocoyl taurate , sodium lauroylmethyl taurate , fate , TEA /Na C12 - 13 pareth - 3 sulfate, sodium PEG - 3 coc sodium laurylsulfoacetate , sodium cocoyl methyl alanine amide sulfate , sodium PEG - 5 cocamide phosphate , diso solution , cocoyl triethanolamine solution , sodium lauroyl dium PEG - 5 laurylcitrate sulfosuccinate , PPG - 5 - ceteth - 10 , methyl - ß - alanine solution , disodium lauryl- N - car - PEG - 25 butyl phosphate , sodium C14 - 18 alkyl sulfonate , boxymethoxyethyl- N - carboxymethyl- imidazolinium dode - 10 C20 - 22 alkyl phosphate , isolaureth - 4 phosphate , undecyle canoyl Sarcosine , sodium coco alkyl - N - carboxyethyl - N - noyl glycine , potassium olive fatty acid , oleyl sarcosine, hydroxyimidazolium betaine , disodium coco alkyl- N - sodium oleyl methyl taurate , oleth - 3 phosphate , oleth - 4 carboxyethoxyethyl- N - carboxyethyl- imidazolinium phosphate , oleth -5 phosphate , oleth -10 phosphate , oleth - 20 hydroxide, disodium coco alkyl- N - carboxymethoxyethyl- phosphate , sodium oleth - 7 phosphate , sodium oleth - 8 phos N -carboxymethyl - imidazo linium hydroxide , disodium coco 15 phate , sodium C14 - 16 olefin sulfonate , capryloyl glycine ; alkyl- N - carboxymethoxyethyl- N -carboxymethyl - imidazo cocoyl glutamates such as sodium cocoyl amino acids, linium lauroyl sulfate , sodium myristoylmethyl -ß -alanine cocoyl alanine triethanolamine , sodium cocoyl isethionate , solution , sodium methyl stearoyl taurate , sodium tetrade ammonium cocoyl isethionate , potassium cocoyl glycine , cene sulfonate , sodium dodecylbenzene sulfonate , trietha - sodium cocoyl glycine , triethanolamine cocoyl glutamate , nolamine dodecylbenzene sulfonate , sodium alkanesul - 20 cocoyl glutamate , disodium cocoyl glutamate , and potas fonate , ammonium alkyl sulfate , sodium octylphenoxy sium cocoyl glutamate ; cocoyl sarcosine , sodium cocoyl diethoxyethyl sulfonate , triethanolamine/ magnesium coco sarcosinate, triethanolamine cocoyl sarcosinate, sodium alkyl sulfate , sodium myristyl sulfate , sodium cetostearyl cocoyl taurate , cocoyl methyl ß - alanine , sodium cocoyl sulfate , sodium oleyl sulfate , triethanol amine oleyl sulfate , methyl B - alanine , methyl cocoyl taurate , potassium methyl sodium polyoxyethylene lauryl ether sulfate , ammonium 25 cocoyl taurate , magnesium methyl cocoyl taurate , sodium polyoxyethylene lauryl ether sulfate (2E . O . ) , trietha - methyl cocoyl taurate , sodium cocoyl apple amino acids, nolamine polyoxyethylene lauryl ether sulfate , ammonium sodium coceth sulfate , di -C11 - 15 pareth - 2 phosphate , polyoxyethylene alkyl ether sulfate ( 3E . O . ) solution , dietha di- C12 - 15 pareth - 4 phosphate , di- C12 - 15 pareth - 8 phos nolamine polyoxyethylene alkyl ether sulfate ( 3E . O . ) solu phate , di- C12 - 15 pareth - 10 phosphate , dioleyl phosphate , tion , triethanolamine polyoxyethylene alkyl ether sulfate 30 sodium dioleth - 8 phosphate , sodium dioleth - 8 phosphate , (3E . O . ) solution , sodium polyoxyethylene alkyl ether sulfate sodium dicocoylethylenediamine PEG - 15 sulfate , sodium ( 3E . O . ) solution , sodium cocomonoglyceride sulfate , poly - dilaureth - 10 phosphate , steareth - 2 phosphate , steareth - 3 oxyethylene ( 5 ) coconut fatty acid monoethanolamide phos p hosphate , calcium stearoyl lactylate , sodium stearoyl lac phate ; polyoxyethylenealkyl (12 - 14 ) ether phosphate tylate , disodium undecylenamido MEA - sulfosuccinate , ( 2E .O .) , ( 8E . O .) , ( 10E . O .) ; polyoxyethylene laurylether 35 disodium lauramido MEA -sulfosuccinate , disodiumlaureth phosphate , sodium polyoxyethylene laurylether phosphate , sulfosuccinate , DEA -cetyl phosphate , potassium cetyl phos polyoxyethylene cetylether phosphate , sodium polyoxyeth - phate , sodium cetyl stearyl sulfate , ceteth - 10 phosphate , ylene cetylether phosphate , polyoxyethylene stearylether, ceteth - 20 phosphate , triceteareth - 4 phosphate , trideceth - 4 polyoxyethylene cholestearyl ether , polyoxyethylene steary carboxylic acid , trideceth - 8 carboxylic acid , sodium tride lether phosphate , polyoxyethylene oleylether phosphate , 40 ceth -4 carboxylic acid , sodium trideceth - 7 carboxylic acid , sodium polyoxyethylene oleylether phosphate , dietha sodium trideceth - 3 carboxylic acid , potassium trideceth - 7 nolamine polyoxyethylene oleylether phosphate , polyoxy - carboxylic acid , trilaureth - 4 phosphate , oleyl lactate , sodium ethylene alkylphenylether phosphate , triethanolamine poly - palmoyl glutamate , magnesium palmitoyl glutamate , oxyethylene alkylphenylether phosphate , polyoxyethylene - sodium palmitoyl sarcosinate , palmitoyl proline , sodium polyoxypropylene cetylether phosphate , polyoxypropylene 45 palmitoyl proline , sodium methyl palmitoyl taurate , potas glyceryl ether phosphate , polyoxypropylene butyl ether sium myristoyl glutamate , sodium myristoyl glutamate , phosphate, disodium laureth sulfosuccinate , sodium cocoyl sodium myristoyl sarcosinate , sodium methyl myristoyl ethyl ester sulfonate , dioctyl sodium sulfosuccinate , sodium taurate , potassium cocoate , triethanolamine cocoate , argi octylphenoxy diethoxyethyl sulfonate , disodium lauryl sul- nine cocoate , disodium lauryliminodiacetate , sodium lauryl fosuccinate , disodium oleic acid amidosulfosuccinate , C12 - 50 glycol carboxylate , laureth - 5 carboxylic acid , laureth - 6 car 15 pareth - 3 phosphate , sodium polyoxyethylene alkyl (C12 - boxylic acid , laureth - 11 carboxylic acid , sodiumlaureth - 5 14 ) sulfosuccinate (7E . O .) , disodium lauramido PEG - 5 carboxylate , sodiumlaureth -6 carboxylate , sodiumlaureth - 11 sulfosuccinate (5E . O . ) , sodium isostearoyl lactylate , sodium carboxylate , laureth - 5 acetate , laureth - 6 acetate , potassium undecylenoyl hydrolyzed collagen , potassium undecylenoyl laureth - 4 , 5 acetate , sodiumlaureth - 3 acetate , sodiumlau hydrolyzed collagen , sodium 2 -undecyl - 1- hydroxyethyl 55 reth -4 acetate, sodiumlaureth -5 acetate , sodiumlaureth - 6 imidazolinium betaine , sodium lauroyl hydrolyzed collagen , acetate , sodiumlaureth - 11 acetate , MIPA - laureth sulfate , sodium cocoyl hydrolyzed collagen , potassium cocoyl sodium laureth sulfate , triethanolamine laureth sulfate , hydrolyzed collagen , potassium cocoyl hydrolyzed collagen ammoniumlaureth - 2 sulfate , ammoniumlaureth - 3 sulfate , solution , TEA - cocoyl hydrolyzed collagen , isostearoyl laureth - 1 phosphate , laureth - 2 phosphate , laureth - 4 phos hydrolyzed collagen , isostearoyl hydrolyzed silk , AMPD - 60 phate , sodium lauroylaspartate , sodium lauryl oat amino isostearoyl hydrolyzed collagen , ethylenediamine - N , N , N ', acids, sodium lauroyl lactate , N - lauroyl- N -methyl - ß - alanine N '- tetrakis ( 2 - hydroxylpropyl) dioleate , dodecanoylsar - potassium salt, TEA - lauroyl methylaminopropionate , dice cosine , sodium lauriminodipropionate ( 30 % ) , oleoyl tyl phosphate , and cetyl phosphate ; cation surfactants such sarcosine , sodium myristoyl B - alanine solution , sodium as lauryl trimethyl ammonium chloride , dicocodimonium undecylhydroxyethylimidazolinium betaine , ammonium 65 chloride , myristyl dimethyl benzyl ammonium chloride , C12 , 13 , 16 alkyl sulfate, triethanolamine alkyl (11 , 13 , 15 ) cetyltrimethylammonium chloride, laurylpyridinium chlo sulfate ( 1) , triethanolamine alkyl (11 ,13 , 15 ) sulfate (2 ), ride, cetylpyridinium chloride , benzethonium chloride , US 10 , 111 ,822 B2 31 32 stearyl trimonium chloride , benzalkonium chloride , ben - amideamine- types including lauryl dimethyl amino acetate zalkonium chloride solution , lauramine oxide , alkyltrimeth - betaine , 2 - alkyl- N -carboxymethyl - N -hydroxyethylimidazo ylammonium chloride, stearyl trimethyl ammonium chlo linium betaine, undecyl- N -hydroxyethyl - N - carboxymethyl ride, stearyl dimethyl benzyl ammonium chloride , dimethyl imidazolinium betaine , palm oil alkyl betaine , cocamidopro stearyl ammonium chloride treated hectorite , benzyl dim - 5 pyl betaine , stearyl dihydroxyethyl betaine , stearyl betaine ethyl stearyl ammonium chloride treated hectorite , dis dimethylamino acetate , bis ( stearyl- N - hydroxyethylimidazo tearyldimonium chloride, benzyl dimethyl stearyl ammo nium chloride treated hectorite , distearyldimonium chloride , line )chloroacetic acid complex, cocoyl hydrolyzed collagen , distearyldimonium chloride treated bentonite , dialkyldim oleoyl hydrolyzed collagen , hexadecyl hydrolyzed collagen , ethyl ammonium chloride , tri ( polyoxyethylene ) stearyl 10 lauramidopropyl betaine /water , myristoyl hydrolyzed colla ammonium chloride ( 5E . O . ) , di ( polyoxyethylene ) oleyl gen , alkyl aminoethyl glycine chloride solution , and lecithin ; methyl ammonium chloride ( 2E . O . ), N - ( stearoyl colamino and others including PEG - 3 lauramine oxide , oleamine formyl methyl) pyridinium chloride, polyoxypropylene oxide , oleyl betaine , capryl/ capramidopropyl betaine , methyl diethyl ammonium chloride , alkyldiaminoethylgly cocamine oxide , sodium cocoamphoacetate, sodium coco cine hydrochloride solution , alkylisoquinolinium bromide 15 amphodiacetate , disodium cocoamphodiacetate , sodium solution , laurtrimonium bromide, ammonium cetyl trimethyl cocoamphopropionate , dihydroxyethyl lauramine oxide , bromide , stearyl trimethyl ammonium bromide, cetyltrim stearamine oxide , stearyl betaine , sodium palm kernelami ethylammonium saccharin , stearyltrimethylammonium sac doethyl hydroxyethyl amino propionate , palm kernelami charin , polyethyleneglycol•epichlorohydrin•coconut dopropyl betaine , C12 - 14 hydroxyalkyl hydroxyethyl ß - ala alkylamine•dipropylenetriamine condensate , 20 nine, hepta hydroxyethyl carboxylate methylimidazolinium polyethyleneglycol•epichlorohydrinetallow alkyl amine chloride /hepta decyl bis -hydroxyethyl imidazolinium , •dipropylenetriamine condensate, ethyl sulfate lanolin fatty myristamidopropyl betaine, myristamine oxide , myristyl acid aminopropyl ethyl dimethyl ammonium (1 ), ( 2 ) ; behe - betaine , lauramidopropylamine oxide, lauramidopropyl nyl trimethyl ammonium bromide , behenic acid amide pro - hydroxysultaine , lauramidopropyl betaine , sodium lau pyl dimethyl hydroxypropyl ammonium chloride , stearic 25 raminopropionate , lauramine oxide , sodium lauriminodipro acid diethylaminoethylamide , stearic acid diethylaminoethyl p ionate , lauryl hydroxysultaine, lauryl betaine, sodium lau amide , stearic acid dimethylaminopropylamide , lanolin roamphoacetate , and lauroyl lysine; escin , sodium surfactin , derivative quaternary ammonium salt , PEG - 5 oleamine , saponin , hydroxylated lecithin , hydrogenated lysolecithin , PEG - 2 oleammonium chloride , PEG - 2 cocamine, PEG - 3 hydrogenated lecithin , cephalin , phosphatidyl serine, lyso cocamine , PEG - 5 cocamine , PEG - 10 cocamine , PEG - 15 30 lecithin , phospholipid , lecithin , and soluble collagen . cocamine , PEG - 2 dimeadowfoamamidoethylmonium Among these surfactants , non - ionic surfactants are prefer methosulfate , hydroxypropyl arginine lauryl /myristyl ether able ; i. e ., polyoxyethylene alkyl ether, polyoxyethylene fatty HCl, ceteartrimonium chloride , C10 -40 isoalkylamidopro - acid ester , polyoxyethylene sorbitan fatty acid ester, glyc pylethyldimonium ethosulfate , isostearyl ethylimidazolium erin - fatty acid ester, polyglycerol fatty acid ester series , ethosulfate , caesalpinia spinosa hydroxypropyltrimonium 35 polyoxyethylene glycerine fatty acid ester, polyoxyethylene chloride , quaternium -33 , quaternium - 91, cocamidopropyl hydrogenated castor oil, polyoxyethylene sorbitol fatty acid PG -dimonium chloride phosphate , cocamidopropyl betaina ester , etc ., are more preferable . mide MEA chloride, PCA ethyl cocoyl arginate , cocotrimo - Particularly , in the case of cosmetic lotions in which the nium methosulfate, trigonella foenum - graecum hydroxypro - external dermal composition containing one or more pyltrimonium chloride, myrist / palmitamidobutyl guanidine 40 L - ascorbic acid , derivatives thereof, and their salts are acetate , di -C12 - 18 alkyl dimonium chloride , dicocoylethyl incorporated , the following surfactants , which are widely hydroxyethylmonium methosulfate , dicocodimonium chlo used in the field of cosmetics and have a higher effect of ride, distearyldimonium chloride, distearoylethyl hydroxy - inhibiting the turbidity or precipitation of cosmetics over ethylmonium methosulfate , dicetyldimonium chloride , time, can be preferably used ; L - arginine ethyl ester •DL dipalmitoylethyl hydroxyethylmonium methosulfate , dihy - 45 pyrrolidone carboxylate , glycereth - 25 PCA isostearate , droxypropyl PEG - 5 linoleammonium chloride , dimethyl PEG - 9 polydimethylsiloxyethyl dimethicone , sorbitan PABA amidopropyl laurdimonium tosylate , dimethyl stear- cocoate, polyoxyethylene polyoxypropylene decyltetradecyl amine , stearamidoethyl diethylamine , stearamidopropyl ether, polyoxyethylene cetylether , polyoxyethylene steary diethylamine , stearalkonium chloride , steartrimonium sac - lether, polyoxyethylene methyl glucoside , polyoxyethylene charinate , steartrimonium chloride , steartrimonium bro - 50 lauryl ether, polyoxyethylene hydrogenated castor oil , poly mide , stearoxypropyltrimonium chloride, cetalkonium chlo - oxyethylene hydrogenated castor oil, sorbitan isostearate , ride, cetylpyridinium chloride , cetrimonium chloride, polyoxyethylene hydrogenated castor oil monoisostearate , cetrimonium bromide , cetrimonium methosulfate , soytrimo - glycerin - fatty acid ester, polyglyceryl diisostearate , sucrose nium chloride, palmitamidopropyltrimonium chloride, pan fatty acid ester, sodium stearoyl glutamate , sodium stearoyl thenyl hydroxypropyl steardimonium chloride , hydroxy - 55 lactylate , sorbitan sesquiisostearate , sorbitan sesquioleate , ethyl cetyldimonium phosphate , hydroxypropyltrimonium polyoxyethylene alkyl ( C12 to C15 ) ether phosphate , poly honey , hydroxypropyl bis -hydroxyethyldimonium chloride , oxyethylene cholesteryl ether , polyoxyethylene cetylether behenamidopropyl dimethylamine , behenamidopropyl dim - phosphate , polyoxyethylene cetostearyl ether , polyoxyeth ethylamine , behentrimonium chloride , behentrimonium ylene phytosterol, polyoxyethylene behenyl ether , polyoxy methosulfate , poloxamine 701 , poloxamine 702 , poloxam - 60 ethylenesorbitanmonooleate ( 20E . O . ) , glyceryl monostear ine 704 , bishydroxyethylbiscetyl malonamide , sodium palm a te , polyethylene glycol monostearate, polyoxyethylene oil alkyl PG dimonium chloride phosphate , laurtrimonium glyceryl monostearate , polyoxyethylene sorbitan monolau chloride, laurylpyridinium chloride, and linoleamidopropyl rate , dioctyldodecyl lauroyl glutamate , hydrolyzed collagen PG -dimonium chloride phosphate ; ampholytic surfactants solution , glyceryl monostearate , hydrogenated lysolecithin , such as of carboxy betaine - , amide betaine -, sulfo betaine -, 65 hydrogenated soybean phospholipid , and soluble collagen , hydroxy sulfobetaine - , amido sulfo betaine - , phospho one or more of which can be desirably used alone or in betaine - , aminocarboxylate -, imidazoline derivative -, and combination . US 10 , 111, 822 B2 33 34 Into the above - identified cosmetic solutions can be incor acetate , tricyclodecenyl acetate , 2 , 4 - dimethyl - 3 - cyclohex porated the following one or more ingredients selected from ene - 1 -methanyl , phenylethyl acetate , styralyl acetate , dim flavors , pigments /dyes , antiseptics , bactericides , ultraviolet - ethylbenzylcarvyl acetate , cinnamyl acetate , anisyl acetate , absorbing agents , sequestering agents , and buffers in respec p -cresyl acetate , heliotropyl acetate , acetyl eugenol, acetyl tive amounts of, usually , at least 0 . 0001 % by mass , prefer - 5 isoeugenol, guaiyl acetate , cedryl acetate , ethyl propionate , ably , 0 .001 to 50 % by mass , more preferably , 0 .01 to 25 % isoamylpropionate, citronellyl propionate , geranyl propi by mass, and more further preferably, 0 . 1 to 10 % by mass to onate , linalyl propionate , terpinyl propionate , benzyl propi the mass of the respective cosmetic solutions of the present onate , cinnamyl propionate , allyl cyclohexylpropionate , tri invention . cyclodecenylpropionate , ethyl butyrate, ethyl ( Flavors ) 10 2 -methylbutyrate , butyl butyrate , isoamyl butyrate , hexyl Examples of the flavors include synthetic and natural butyrate , linalyl butyrate , geranyl butyrate , citronelly1 flavors such as essential oils , as well as compound perfume butyrate , benzyl butyrate , cis - 3 -hecenyl isobutyrate , citro and flavor materials ; aldehydes such as benzaldehyde, cin - nellyl isobutyrate , geranyl isobutyrate , linalyl isobutyrate , namaldehyde , cyclamen aldehyde , citral , citronellal , benzyl isobutyrate , phenylethyl isobutyrate , tricyclodecenyl 2 -methyl - 3 -( 4 -methylphenyl ) propanal, undecenal, methyl- 15 isobutyrate , ethyl isovalerate , propyl pentanoate, citronellyl nonylacetaldehyde , 3 , 7 -dimethyl - 1 - octanal, hydroxycitro isovalerate , geranyl isovalerate , isovaleric acid benzyl ester, nellal, methoxycitronellal, perillaldehyde , myrtenal, isovaleric acid 3 -phenyl - 2 -propenyl ester , isovaleric acid caryophyllene aldehyde , n -hexal , 2 -methylbutanal , isoval phenethyl ester, ethyl caproate , allyl caproate , ethyl enan eraldehyde , n - valeraldehyde , acetaldehyde, n - heptanal, thate , allyl enanthate , ethyl caprate , citronellol tiglate, n -octanal , n -nonanal , 2 -methyloctanal , 3, 5 ,5 - trimethyl hexa - 20 methyl benzoate , ethyl benzoate , butyl benzoate , isoamyl nal , 1 - decanal, undecanal, dodecanal, 2 -methyl decanal, benzoate , geranyl benzoate , linalyl benzoate , benzyl benzo 2 -methyl undecanal , tridecanal , tetradecanal, 2 -pentenal , ate , phenylethyl benzoate , methyl phenyl acetate , ethyl cis - 3 -hexenal , trans - 2 -hexenal , trans - 2 -heptenal , 4 -heptenal , phenyl acetate , isobutyl phenyl acetate , isoamyl phenyl trans -2 -octenal , trans -2 -nonenal , cis -6 -nonenal , 2 ,6 - dim acetate , geranylphenyl acetate , benzyl phenyl acetate , phe ethyl- 5 - heptenal, trans- 4 - decenal, cis - 4 - decenal, trans - 2 - de - 25 nylethyl phenyl acetate , p -crezyl phenyl acetate , methyl cenal, 2 , 5 , 6 - trimethyl- 4 -heptenal , 10 - undecenal, trans - 2 - un - cinnamate , ethyl cinnamate , benzyl cinnamate , cinnamyl decenal , trans - 2 - dodecenal, 3 - dodecenal, trans- 2 -tridecenal , cinnamate , phenylethyl cinnamate , methyl salicylate , ethyl 2 ,6 , 10 - trimethyl- 9 - undecene- 1 - al, 2 , 4 -hexadienal , 2 , 4 -hep salicylate , isobutyl salicylate, amyl salicylate , hexyl salicy tadienal, 2 , 4 - octadienal, 2 , 4 - nonadienal, 2 , 6 -nonadienal , late , cis - 3 - hexenyl salicylate , phenylethyl salicylate , methyl 2 , 4 -decadienal , 2 , 4 - undecadienal , 2 , 4 -dodecadienal , 5 , 9 - di- 30 jasmonate , methyl dihydrojasmonate , ethyl tricyclodecan - 2 methyl- 4 , 8 - decadienal , 3 , 7 , 9 - trimethyl- 2 , 6 - decadiene - 1 - al, yl- carboxylate (“ FRUITATE ” ) , allyl 2 -pentyloxyglycolate , 2 ,6 , 10 - trimethyl- 5 , 9 -undecadienal , a -methylene citronellal, ethyl 3 -methyl - 3 -phenylglycidate , ethyl 2 -pentanoate , 4 -ac campholenic aldehyde , cyclocitral, isocyclocitral, 2 , 6 ,6 - etoxy - 3 - amyltetrahydropyrane , cyclohexyl salicylate , ethyl trimethyl- 1 , 3 - cyclohexadiene - 1 - carboxy aldehyde, 6 , 10 -di 2 - cyclohexyl propionate , ethyl tricyclo [ 5 . 2 . 1 .02 , 6 ]decane methyl- 3 -oxa - 9 -undecenal , geranyloxyacetaldehyde, dim - 35 2 -carboxylate , and 2 -methylpenthyl 2 -methylpentylate ; lac ethyl tetrahydrobenzaldehyde, 3 -propyl bicyclo [2 , 2 ,1 ]- 5 - tones such as y -undecalactone , pentalide (cyclopentadecano hepten -2 -carboxyaldehyde , methoxydicyclopentadiene lide) , habanolide (1 -oxa - cyclohexadecen -2 -one ) , carboxyaldehyde , 4 - tricyclodecylidene butanal, 4 - ( 4 - ambrettolide , cyclohexadecanolide , 10 -oxahexadecanolide , methyl- 3 -cyclohexenylidene - 1 )pentanal , 4 ( 3 ) - ( 4 -methyl - 3 - 11 -oxahexadecanolide , 12 - oxahexadecanolide , ethylene pentene- 1 -yl ) - 3 -cyclohexene - 1 -carboxyaldehyde , cetonal, 40 dodecanedioate , y -butyrolactone , y - valerolactone , angelica inonal , terrestral , p - tolylaldehyde, phenylacetaldehyde , lactone, y -hexanolactone , y -heptalactone , y -octalactone , 3 -phenylbutanal , cuminaldehyde, p -methylphenylacetalde - y- nonalactone , 3 -methyl - 4 -octanolide , y -decalactone , y -do hyde , p - isopropylphenylacetaldehyde , hydratropaldehyde, decalactone, y - jasmolactone , jasmine lactone, cis -jasmon p -methylhydratropaldehyde , p - isopropyl hydra toro pa alde - lactone, lactojasmon , jasmolactone ,menthalactone , n - butyl hyde , phenylpropionaldehyde , B -methylhydrocinnamic 45 phthalide , propylidenephthalide, butylidenephthalide, aldehyde , jasmorange, bourgeonal, floralozone , suzaral, d -hexalactone , d - octalactone, 4 , 6 , 6 ( 4 , 4 , 6 - trimetyltetrahy salicylaldehyde , anisaldehyde , o -methoxybenzaldehyde , dropyran - 2 -on , d -nonalactone , d -decalactone , 8 - 2 - deceno 0 -methoxycinnamicaldehyde , canthoxal, vanillin , ethyl van - lactone , d -undecalactone , d - dodecalactone, S -tridecalac illin , methyl vanilline ( 3 , 4 - dimethoxybenzaldehyde ), tone , S -tetradecalactone , lactoscaton ( decahydro - 4 , a helional, phenoxyacetaldehyde , p -methylphenoxyacetalde - 50 hydroxy - 2, 8 ,8 - trimethylnaphtalin - 2 - carboxy acid -8 hyde , furfural, 5 -methylfurfural , 5 - hydroxymethyl- 2 - fur - lactone ) , coumarin , dihydrocoumarin , cyclohexyl lactone , fural, furylacrolein , lyral, bern aldehyde , homomyrac alde 6 -methyl coumarin , E - decalactone , and E - dodecalactone ; hyde , junipal , vertral, lilial , mefranal, eglantal, cocarl , ketones such as acetyl caryophyllene, carvone , pulegone , a - methylcinnamaldehyde , a -butylcinnamaldehyde , a - am piperitenone , piperitone , camphor, isolongifolanone, noot ylsinecinnamaldehyde , a -hexylcinnamaldehyde , and formy- 55 katone, 2 -heptanone , 2 -pentanone , 3 -hexanone , 3 - hep lethyltetramethyltetralin ; esters such as terpinel acetate , tanone, 4 -heptanone , 2 -octanone , 3 -octanone , 2 - nonanone , vetiveryl acetate , benzyl acetate , linalyl acetate, isopentyl 3 -nonanone , 2 -undecanone , 2 - tridecanone, methyl isopropyl salicylate , benzyl salicylate , hexyl salicylate , cis - 3 -hexenyl ketone , ethyl isoamyl ketone, mesityl oxide , butylidene salicylate , ethyl formate , cis - 3- hexenyl formate , linalyl for- acetone, methylheptadienon , methylheptenon , dimethyl mate , citronellyl formate , geranyl formate , benzyl formate , 60 octenone , 4 -methylene - 3 , 5 , 6 , 6 -tetramethyl - 2 -heptanone , phenylethyl formate , ethyl acetate , butyl acetate , isoamyl geranylacetone , farnesylacetone , acetoin , 5 -hydroxy - 4 -oc acetate , methyl cyclopentylidene acetate, hexyl acetate , cis - tanone , methyl lavender ketone , diacetyl, 2 , 3 -pentadione , 3 -hexenyl acetate , trans -2 -hexenyl acetate , isononyl acetate , 2 ,3 -hexadione , 3 ,4 -hexadione , 2 , 3 -heptadione , acetylisoval citronellyl acetate , lavandulyl acetate , geranyl acetate , eryl, amylcyclopentanone, amylcyclopentenone , 2 - cyclo myrcenyl acetate , terpinyl acetate , menthyl acetate , mentha - 65 pentylcyclopentanone, hexylcyclopentanone , 2 - n -heptylcy nyl acetate , nopyl acetate , n -bornyl acetate , isobornyl clopentanone , cis- jasmon , dihydrojasmon , isojasmon , acetate , p - t - butylcyclohexyl acetate , o - t- butylcyclohexyl trimethyl pentyl cyclopentanone , sedamon ( 2 - butylidene - 3 , US 10 , 111 , 822 B2 35 36 5 ,5 (3 , 3 , 5 ) -trimethyl cyclopentanone ) , sandex ( 3 -methyl -5 wood oil, guaiac resin , guaiac concrete , Cinnamomum cam ( 2 , 2 , 3 -trimethyl - 3 - cyclopentenyl) - 3 - pentene - 2 -on , cyclo - phora oil, cubeb oil , cumin oil , cumin absolute , cumin tene , 3 , 5 - dimethyl- 1 , 2 -cyclopentadione , methylcholine, 2 -t oleoresin , clary sage oil, grapefruit oil, costus oil , copaiba butylcyclohexanone, p -t - butylcyclohexanone , 3, 3 -dimethyl balsam , copaiba balsam oil , copaiba balsam resin , coriander cyclohexyl methyl ketone , 2 - sec -butylcyclohexanone , arte - 5 oil, sassafras oil, broom absolute , perilla oil, citronella oil, mone , celery ketone ( 3 -methyl - 5 - propyl- 2 -cyclohexenone ), jasmin concrete , juniper berry oil , civet absolute , civet krypton , p - t -penthylcyclohexanone , methylcyclocitron , tincture , jonquil absolute , agarwood , ginger oil , cinnamon nerone , 4 -cyclohexyl - 4 -methyl - 2 -pentanone , habanor ( 2 - ( 1 oil, cinnamon leaf oil , Japanese cedar oil , styrax oil , spear cyclohexene - 1 - yl) -cyclohexanone ), maltol, ethyl maltol, mint oil , savory oil , sage oil , cedar oil , cedar leaf oil, target oxide ketone , emoxyfurone ( 5 - ethyl - 3 - hydroxy - 4 -methyl - 2 10 oil , tarragon oil , dill oil, tea tree oil, tree moss absolute , tolu 55H ] - furanone , homofuraneol ( 2 - ethyl - 4 -hydroxy - 5 -methyl - balsam , nutmeg oil , Narcissus absolute , neroli oil , violet leaf 3 [2H ] - furanone and 5 - ethyl- 4 -hydroxy - 2 -methyl - 3 [ 2H ] - absolute , pine oil, basil oil, parsley leaf oil , parsley seed oil , furanone ), sotolon , furaneol, acetyl dimethylfuran , parsley herb , mint oil, vanilla absolute , honeysuckle abso furfuralacetone , 2 - acetyl- 5 -methylfuran , 2 - acetylfuran , lute , palmarosa oil , valerian oil , bitter orange oil, hyssop oil , methyltetrahydrofuranone , dibenzyl ketone , benzophenone , 15 hiba oil ( Thujopsis dolabrata wood oil ) , hyacinth absolute , methyl naphthyl ketone, 4 - damascol (5 -phenyl - 5 -methyl - 3 fennel oil , fig absolute , buchu oil , pennyroyal oil , pepper hexanone ), 4 -methyl - 4 - phenyl- 2 - pentanone, a -methylanisa mint oil, benzoin tincture , benzoin resinoid , Bois de rose oil, lacetone , heliotropylacetone, anisylideneacetone, anisylac - houshou oil , hop oil , hop concrete, hop absolute , marjoram etone , p -methoxyphenylacetone , raspberry ketone , oil, mandarin oil , orange oil, mimosa concrete , mimosa lavandozon ( 3 -methyl - 4 - phenyl- 3 - butene - 2 - on ), benzylide - 20 absolute , mimosa oil, mill absolute , mill oil, musk absolute , neacetone , p -methoxyacetophenone , p -methylacetophe musk tincture , Citrus junos oil , Artemisia oil , abdanum none , propiophenone , acetophenone, isodamascone , a - dy ( rockrose ) oil, abdanum resinoid , lavender absolute , lavan nascone , “ IRITONE ” ( trimethylcyclohexenylbutenone ), din oil , lavandin absolute , linaloe oil, lemon grass oil, rose “ INONE ” , pseudoionone, methyl ionone , methyliritone , concrete , lavage oil , Laurus nobilis oil , Laurus nobilis leaf 2 , 4 - di - t -butylcyclohexanone , allylionone , 2 , 6 , 6 - trimethyl - 2 - 25 oil , wormwood oil, musk , civet, ambergris , castoreum , musk cyclohexene - 1 , 4 - dione , 2 -acetyl - 3 ,3 - dimethylnorbornane , zibata , a - pinene, B - pinene, camphene, myrcene , terpineol, " FLOREX ” (hydro - 5 , 8 -methano - 2H - 1 -benzopyran ) , “ PLI - terpinolen , ocimene , y -terpinene , A -phellandrene , p - cy CATONE ” ( 4 -methyltricyclo [ 6 .2 .1 .02 .7 ]undecan -5 -one , mene, ß -caryophyllene , B - farnesene , 1 ,3 ,5 - undecatriene , oxocedrane , beltfix , verbenone , fenchone , calone , trimofix and diphenylmethane ; alcohols such as anise alcohol, cin 0 , epitone , atrinon , cashmeran , 3 -methylcyclopentade - 30 namic alcohol, phenyl propyl alcohol, dimethyl benzyl car canone - 1 , cycloheptadeca - 9 - en - 1 -one , cyclopentadecanone , binol, phenylethyl methyl ethyl carbinol, 3 -methyl - 5 - phe cyclohexadecenone , phantolide, 4 - acetyl- 6 -t - butyl- 1 , 1 - dim - nylpentanol, orcinol monomethyl ether, isoeugenol, ethylindan , “ TRASEOLIDE ” ( 5 - acetyl - 1 , 1 , 2 , 6 - tetraméth - santalol, isobornyl cyclohexanol, “ SANDALORE” ( a syn yle - 3 - isopropyl - dihydroindene ) , tonalid , “ VITALIDE ” thetic sandalwood oil) , “ BACDANOL ” ( 2 - ethyl - 4 - ( 2 , 2 , 3 ( acetyldimethyl tetrahydrobenzindan ), dihydrocarvone , dio - 35 trimethylcyclopent - 3 -en -yl ) - but- 2 - en - 1 - ol) , “ SAN sphenol, zingerone, and iso E super , carbohydrates such as DALMYSORE CORE” ( 2 -methyl - 4 - ( 2 , 2 , 3 - trimethyl - 3 phenylacetic acid , “ SANDALORE ” , linalool, musk ketone , cyclopneten - 1 - yl) - 2 -buten - 1 - ol) , “ BRAMANOL ” , methyl ionone , iris oil, irone, indole , ylang -ylang oil , “ EBANOL ” ( 3 -methyl - 5 -( 2 ,2 , 3 - trimethyl- 3 -cyclopente estragole , oakmoss , opoponax resinoid , eugenol, aurantiol, nyl ) - 4 -pentene - 2 -ol ; 3 -methyl - 5 -( 2 ,2 , 3 - trimethyl- 3 -cyclo galaxolide , carvacrol, L -carvone , camphor, canon , carrot 40 penten - 1 -yl ) -4 - penten - 2 - 0 ), “ POLYSANTOL ” , 2 - ethoxy -4 seed oil , clove oil , geraniol, geranylnitrile , sandalwood oil, methoxymethylphenol, trans - 2 - hexenol, cis - 3 -hexenol , cyclopentadecanolide, dihydromyrcenol, jasmine absolute , 3 -octanol , 1 -octen - 3 - o1 , 2 , 6 - dimethyl- 2 -heptanol , 9 - dece cinnamon bark oil , 1, 8 -cineol , styrax resinoid , cedarwood nol, 4 -methyl -3 -decen -5 - ol, 10 -undecenol , trans- 2 -cis -6 oil , cedrene , cedrol, celery seed oil , thyme oil, damascone , nonadienol, nerol, citronellol , rhodinol , myrcenol, lavan damascenone , thymol , tuberose absolute , decanolactone , 45 dulol , tetrahydrogeraniol, tetrahydrolinalool, terpineol, y - terpinene , “ TRIPRAL ” ( dimethyl tetrahyd - hydroxycitronellol, alloocimenol, terpinene - 4 - 01, isop robenzaldehyde ) , 2 ,6 -nonadienol , nonalactone , patchouli ulegol, nopol, farnesol, nerolidol, bisabolol, patchouli alco alcohol, patchouli oil , phenethyl alcohol, petitgrain oil, hol, 2, 4 - dimethyl- 3 -cyclohexene - 1 -methanol , 4 -isopropyl cis -3 -hexcenol , peru balsam , vetivert oil , vetivelol , pepper cyclohexanol, 4 - isopropylcyclohexane -methanol - 1 - ( 4 mint oil , pepper oil, heliotropine , bergamot oil, borneol, 50 isopropylcyclohexyl ) ethanol , 2 , 2 - dimethyl- 3 - ( 3 myrrh resinoid , menthol, 1 -menthol , 1 -menthone , eucalyptus methylphenyl) propanol , p - t -butylcyclohexanol , 0 -t oil, B - ionone , lime oil , lavender oil, d - limonene , lemon oil, butylcyclohexanol, ambrinol, benzyl alcohol, phenylethyl rose absolute , rose oxide , rose oil , rosemary oil , asafetida alcohol, phenoxyethanol, and styralyl alcohol; and ethers resinoid , ajowan oil, star anise oil, abies oil , amyris oil, such as methyl dihydrojasmonate, tetrahydrofurfuryl 3 -mer ambrette seed oil, ambergris tincture , ylang ylang absolute , 55 captopropionate , kovanol, geranium oil, birch oil , AlMoise iris resinoid , iris absolute , wintergreen oil, elemi oleoresin , oil acetyl cedrene, amylcinnamaldehyde, allylamylglyco elemi resinoid absolute , elemi tincture, oakmoss concrete , late , B - ionone, isobutyl quinoline , nerol oxide, myroxyde, oakmoss absolute , oakmoss resin , oakmoss resinoid , ocotea rose oxide , limetol, menthofuran , linalool oxide , butyldim oil , Osmanthus absolute , Osmanthus concrete , Opoponax ethyl dihydropyran , acetoxy amyl tetrahydropyran , cedryl resinoid , Opoponax absolute , Opoponax oil , Oribanum resi- 60 methyl ether, methoxycyclododecane , 1 -methyl - 1 -methoxy noid , Oribanum absolute , Oribanum oil , allspice oil , cyclododecane, ethoxy methyl cyclo dodecyl ether , tricy Oregano oil , Oregano oleoresin , orange flower absolute , clodecenyl methyl ether, rhubofix , cedroxide, ambroxane , orange flower concrete , cananga oil, gurjun balsam , casca grisalva , Bowajirisu , anisole, dimethylhydroquinone , p - cre rilla bark oil, castoreum absolute , cassie absolute , cassie syl methyl ether , acetoanisole , anethole , dihydroanethole , flower oil , cassia oil, gardenia absolute , carnation absolute , 65 diphenyloxide , methyl eugenol, methyl isoeugenol, benzyl cabreuva oil , chamomile oil, cardamon oil, galvanum oil, isoeugenol, phenylethylisoamylether, d - naphthyl methyl galvanum resin , galvanum resinoid , caraway seed oil, guaiac ether , d -naphthyl ethyl ether, d -naphthyl isobutyl ether , US 10 , 111, 822 B2 37 38 2 , 4 -dimethyl - 4 -phenyltetrahydrofuran , galaxolide , and 2 , 2 , taric aldehyde , diethyl pyrocarbonate , ethylene oxide, B - pro 5 ,5 - tetramethyl- 4 - isopropyl- 1, 3 -dioxane . piolactone , hydrogen peroxide solution , sulfur, potassium (Pigments ) gluconate , DMDM hydantoin , alkyl( C12 - 14 ) diethylamino Examples of the pigments include natural pigments such ethy glycine hydrochloride , quaternium -80 , quaternium -87 , as anthraquinone, anthocyanin , chalkone , carotenoid , fla - 5 chloramine- T , cymen - 5 -ol , iodopropynyl butylcarbamate , vonoid , flavin , quinone , porphyrin , diketone, and pentacya - polyaminopropyl biguanide , methylisothiazoline, methyl nidin series of annatto , acrosin , capsanthin , shisonin , hibis - chloroisothiazoline , and dimethylaminostyryl heptyl methyl cus color, grapeskin extract, safflower yellow , cacao thiazolium iodide . The following plant extracts can be pigment, laccaic acid , carminic acid , curcumin , betanin , advantageously used as antimicrobials ; Echinacea angusti monascorubrin , brazilin , caramel, carthamin pigment, gar- 10 folia leaf extract, Phellodendron amurense bark extract , denia pigment , Lithospermi radix pigment, and cochineal; olive leaf extract , orange juice , Artemisia capillaris extract , photosensitizing dyes such as photosensitizing dyes 101 , licorice flavonoid , Sasa veitchii leaf extract , grapefruit 201, 301 , and 401 ; organic pigment powders of zirconium , extract , chlorphenesin , Lonicera Japonica flower extract , barium , or aluminum chelate such as red Nos. 2 , 3 , 102 , 104 , phenoxyethanol, Beefsteak geranium extract, and San 105 , 106 , 201, 202 , 203 , 204 , 205 , 206 , 207 , 208 , 213 , 214 , 15 guisorba officinalis extract . 215 , 218 , 219 , 220 , 221 , 223 , 225 , 226 , 227 , 228 , 230 , 231 , Among the above antimicrobials, non -paraoxybenzoic and 232; orange Nos. 201, 203, 204, 205, 206 , and 207 ; food esters such as 1 , 2 - alkane diols and 1 , 3 - butylene glycols are yellow Nos. 4 and 5 ; FD & C green Nos . 3 , 201, 202 , 204 , particularly preferable because of their relatively low skin and 205 ; yellow Nos. 201 , 202 , 203 , 204 , 205 , 401 , 402 , 403 , irritation , high antiseptic effect, and humectancy . Examples 404 , 405 , 406 , and 407 ; green Nos. 401 , and 402 ; blue No. 20 of such 1 , 2 - alkane diols include those with carbon atom 403 ; violet No . 401; black No . 401, blue No. 404 , red Nos. numbers of 4 to 10 are preferable , particularly , 1 , 2 - alkane 401, 404, 405 , 501 , 502 , 503 , 504 , and 506 ; orange Nos . 401 , diols selected from one or more of 1 , 2 - pentane diol ( pen 402 , and 403 ; red No . 505 ; blue Nos. 1 , 2 , 201, 202, 203 , tylene glycol) , 1 , 2 -hexane diol, 1, 2 -heptane diol, and 1 , 2 204 , and 205 ; brown No . 201 ; and violet No . 201; and octane diol can be advantageously used depending on their mixture pigments of the above organic pigment powders 25 outstanding compatibilities with ascorbic acid 2 - glucoside incorporated with natural or organic pigments of shikon and sodium salt thereof. color or carthamin . (Ultraviolet Absorbing Agents ) ( Antisetics and Bactericides ) Examples of the ultraviolet absorbing agents include Examples of the antiseptics and bactericides include p -aminobenzoic acid ultraviolet absorbing agents such as paraoxybenzoic acid alkyl esters such as phenol, p - chloro - 30 p - aminobenzoic acid , p - aminobenzoic acid monoglyceryl phenol, p - chlorometacresol, parachlorometaxylenol, resor - ester , N , N - dipropoxyparaaminobenzoic acid ethyl ester, N , cinol, resorcinol monoacetate , orthophenyl phenol, isobu - N -diethoxyparaaminobenzoic acid ethyl ester, N ,N - dimeth tylparaben , ethylparaben , sodium e thylparaben , ylparaaminobenzoic acid ethyl ester, and N , N - dimethyl butylparaben , sodium butylparaben , propylparaben , sodium paraaminobenzoic acid butyl ester ; anthranilic acid ultravio propylparaben , methylparaben , and sodium methylparaben ; 35 let absorbing agents such as homomenthyl - N phenols , benzoic acids , and salts thereof such as phenoxy - acetylanthranilate ; benzophenone derivatives such as ethanol, thymol, cresol, hinokitiol, and hydroxyben - cinnamic acid , oxbenzone - 3 , oxbenzone- 4 , oxbenzone - 5 , zenethiol; benzoic acid and salts thereof; salicylic acid and and oxbenzone - 9 ; saccharide ultraviolet absorbing agents salts thereof; sorbic acid and salts thereof ; dehydroacetic wherein saccharides or sugar alcohols bind to 1 , 3 - propane acid and salts thereof; halogenated bisphenols such as 2 ,4 , 40 diol derivatives; salicylic acid ultraviolet absorbing agents 4 ' -trichloro - 2 -hydroxydiphenylether , hexachlorophen , such as salicylic acid , sodium salt thereof, amyl salicylate , bithionol, and dichlorophen ; amides such as 3 , 4 , 4 - trichlo - menthyl salicylate , homomenthyl salicylate , octyl salicylate , rocarbanilide , 3 - trifluoromethyl 4 , 4 ' -dichlorocarbanilide , phenyl salicylate , benzyl salicylate , p - isopropanolphenyl 3 , 4 , 5 -tribromosalicylanilide , p - amino benzene sulfonamide , salicylate , and dipropylene glycol salicylate ; cinnamic acid and undecylenic acid monoethanolamide ; quaternary ammo - 45 ultraviolet absorbing agents such as octyl cinnamate , ethyl nium compounds such as benzalkonium chloride , lauryl 4 - isopropylcinnamate , methyl- 2 , 5 -diisopropylcinnamate , isoquinolinium bromide , benzethonium chloride, cetylpyri ethyl- 2 , 4 -diisopropylcinnamate , methyl - 2 ,4 -diisopropylcin dinium chloride, dequalinium chloride, and alkyltrimethyl namate , propyl- p -methoxycinnamate , isopropyl- p -methoxy ammonium chloride ; amphoteric surfactants such as alky cinnamate , isoamyl - p -methoxycinnamate , 2 - ethylhexyl laminoethylglycine chloride , and sodium chlorostearyl 50 p -methoxycinnamate , 2 - ethoxyethyl p -methoxycinnamate hydroxyethyl betaine ; chlorhexidine gluconate ; tetrameth - (cinoxate ) , cyclohexyl p -methoxycinnamate , ethyl- a - cyano ylthiuram disulphide; photosensitizing dyes such as photo - B -phenylcinnamate , 2 -ethylhexyl - a -cyano - B -phenylcinna sensitizing dyes 101 , 201, 301, 401 and NK - 143 ; alcohols mate ( octocrylene ), glycerylmono - 2 - ethylhexanoyl- di such as 1 - hydroxypyridine - 2 - thion ( zinc pyrithione ), imida paramethoxycinnamate , and ferulic acid and its derivatives ; zolidinyl urea , N - [ (trichloromethyl ) mercapto ] - 4 - cyclohex - 55 benzophenone ultraviolet absorbing agents such as 2 , 4 ene - 1 , 2 - dicarboximide , lysozyme chloride , chlorphenesin , dihydroxybenzophenone, 2 , 2 - dihydroxy - 4 -methoxybenzo chlorobutanol, 2 -brom -2 -nitro - 1, 3 -propandiol , anise oil, phenone , 2 ,2 - dihydroxy - 4 ,4 '- dimethoxybenzophenone , 2 , 2' , seal oil, citronellol, eugenol, benzyl alcohol, ethanol, 1 , 3 4 , 4 '- tetrahydroxybenzophenone , 2 - hydroxy - 4 butylene glycol, hexylene glycol, dipropylene glycol, glyc methoxybenzophenone , 2 -hydroxy -4 -methoxy -4 ' erin , 1, 2 -propane diol, 1, 2 -butane diol, 1, 2 -pentane diol 60 methylbenzophenone , 2 -hydroxy - 4 -methoxybenzophenone ( pentylene glycol) , 1, 2 - butane diol, 1 , 2 - heptane diol, 1 , 2 5 - sulfonate , 4 -phenylbenzophenone , 2 - ethylhexyl- 4 ' octane diol, 1 , 2 - nonane diol, and 1 , 2 - decane diol; p - chloro - phenylbenzophenone - 2 - carboxylate , 2 - hydroxy - 4 - n metacresol, chlorhexidine hydrochloride , bis ( 2 -pyridylthio octoxybenzophenone, and 4 -hydroxy - 3 1 -oxide )zinc , thianthol, isopropylmethylphenol, 6 -acetoxy - carboxybenzophenone ; dibenzoylmethane derivatives such 2 ,4 - dimethyl- m - dioxane , 5 - chloro - 2 -methyl - 4 - isothiazolin - 65 as 3 - ( 4 '- methylbenzylidene ) - d ,l - camphor, 3 -benzylidene - d , 3 -one , 2 -methyl - 4 - isothiazolin - 3 - on , chlorine , sodium l -camphor , 2 -phenyl - 5 -methylbenzoxazole , 2 , 2 '- hydroxy - 5 hypochlorite , chlorinated lime , iodine, formaldehyde, glu - methylphenylbenzotriazole , 2 - ( 2 ' - hydroxy - 5 ' -t - octylphenyl) US 10 , 111 , 822 B2 39 40 benzotriazole , 2 - ( 2 ' -hydroxy - 5 ' -methylphenyl ) away scurf and dirt created as a result of the physiological benzotriazole , dibenzalazine , dianysoylmethane , 5 - ( 3 , 3 - function inherent to the skin , i. e ., an intense blend of soured dimethyl - 2 -norbornyliden )- 3 -pentane -2 -on , 4 -methoxy - 4 '- t or denatured sebum membranes and desquamated kerati butylbenzoylmethane, and 4 - t nous layers along with dirt such as dust in the air. Concrete butylmethoxydibenzoylmethane; urocanic acid ultraviolet 5 examples of such face -washes include soaps, body sham absorbing agents such as octyltriazone , urocanic acid , and poos, cleansing creams, make - up removers , etc . Alkaline ethyl urocanate ; hydantoin derivatives such as 2 - ( 2 -hy - salts ( soaps ) of higher fatty acids can be listed as ingredients droxy -5 ' -methylphenyl ) benzotriazole , 1 -( 3 ,4 - dimethoxy - having a detergent action ; mainly , sodium , potassium , and phenyl) -4 , 4 - dimethyl- 1 , 3 -pentanedione , octyl dimethoxy - amine salts of Co to Cig fatty acids . benzylidene dioxoimidazolidine propionate , and 10 One or more ingredients selected from flavors , pigments , 2 - ethylhexyl dimethoxybenzylidene dioxoimidazolidine antioxidants , and sequestering agents can be further incor propionate ; and others such as phenylbenzimidazole sulfo - porated into such face -washes to improve and stabilize their nic acid , terephthalylidene dicamphor sulfonic acid , drom quality . Such ingredients can be respectively incorporated in etrizole trisiloxane , methyl anthranilate , rutin and deriva an amount of at least 0 .0001 % by mass, preferably , 0 .001 to tives thereof, oryzanol and derivatives thereof, 15 50 % by mass, more preferably , 0 . 01 to 25 % by mass , and octyldimethyl p - aminobenzoate , titanium oxide , zinc oxide , more further preferably , 0 . 1 to 10 % by mass to the mass of kaolin , talc, ethylhexyltriazone , octocrylene , octyl dimethyl each of the face -washes according to the present invention . PABA , homosalate , methylene bisbenzotriazoryl tetrameth - As such flavors , pigments , and sequestering agents , those ylbutyl phenol, ethylhexyl methoxycinnamate , and octyl which are disclosed in detail in the above -mentioned para methoxycinnamate . 20 graph on cosmetic lotions can be appropriately used . For (Sequestering Agents ) example , the following antioxidants can be appropriately Examples of the sequestering agents include ethylenedi- used as the above antioxidants . aminetetraacetates such as ethylenediaminetetraacetate ( Antioxidants ) ( EDTA ), EDTA2N , EDTA3Na, and EDTA4Na ; hydroxy - Examples of the antioxidants include vitamin A and the ethylethylenediamine triacetates such as sodium salt of 25 like as well as their derivatives and salts such as retinol, hydroxyethylethylenediaminetriacetates ; phosphonic acid dehydroretinol, retinol acetate , retinol palmitate , retinal, and sodium salts thereof or the like such as tripolyphos - retinoic acid , and vitamin A oil ; carotenoid and the like as phoric acid , diethylenetriaminepentaacetates , phytic acid , well as their derivatives such as a - carotene , ß - carotene , and etidronicacid ; poly (aminoacids ) such assodiumoxalate , y -carotene , cryptoxanthin , astaxanthin , and fucoxanthin ; polyaspartic acid , and polyglutamic acid ; and others such as 30 vitamin B and the like as well as their derivatives and salts sodium polyphosphate , sodium metaphosphate, phosphoric such as pyridoxine , pyridoxal , pyridoxal- 5 - phosphate , and acid , pyrophosphate , hexametaphosphate, sodium citrate , pyridoxamine ; vitamin D and the like as well as their citric acid , alanine , dihydroxyethyl glycine , gluconic acid , derivatives and salts such as ergocalciferol, cholecalciferol, succinic acid , and tartaric acid . and 1 , 2 , 5 - dihydroxy cholecalciferol; vitamin D and the like (Buffers ) 35 as well as their derivatives and salts such as a -tocopherol , Examples of the buffers (pH - controlling agents ) include B - tocopherol, y - tocopherol, S - tocopherol, a -tocotrienol , citric acid , sodiumcitrate , lactic acid , sodium actate , glycol B -tocotrienol , y - tocotrienol, S -tocotrienol , tocopherol lic acid , succinic acid , acetic acid , sodium acetate , potassium acetate , and tocopherol nicotinate ; trolox and its derivatives acetate , malic acid , tartaric acid , fumaric acid , phosphoric and salts ; dihydroxytoluene , butylhydroxytoluene, butylhy acid , hydrochloric acid , sulfuric acid , boric acid , borax , 40 droxyanisole , dibutylhydroxytoluene , a -lipoic acid , dehy nitrilotriethanol, monoethanolamine , diethanolamine , tri- drolipoic acid , glutathione , and their derivatives and salts ; ethanolamine , isopropanolamine , triisopropanolamine , uric acid ; erythorbic acid and its derivatives and salts such 2 -amino - 2 -methyl - 1 ,3 -propanediol , 2 -amino - 2 -hydroxym - as erythorbic acid and sodium erythorbate ; gallic acid and its ethyl- 1 , 3 -propanediol , arginine , ammonium hydroxide, derivatives and salts such as gallic acid and propyl gallate ; sodium hydroxide , potassium hydroxide , calcium hydrox - 45 rutin and its derivatives and salts such as rutin and a - gly ide , magnesium hydroxide , potassium hydrogen phosphate cosyl rutin ; triptophan and its derivative and salts ; histidine in ammonia solution , guanidine carbonate , ammonium and its derivatives and salts ; cysteine and its derivatives and bicarbonate , sodium carbonate , potassium carbonate , potas - salts such as N -acetylcysteine , N - acetylhomocysteine , N -oc sium bicarbonate , sodium bicarbonate , magnesium oxide , tanoyl cysteine , and N - acetylcysteine methyl ester ; cystine calcium oxide , ammonium phosphate , disodium hydrogen 50 and its derivatives and salts such as N , N - diacetylcystine phosphate , sodium dihydrogen phosphate , potassium phos - dimethyl ester, N , N -dioctanoylcystine dimethyl ester, and phate , magnesium phosphate , calcium phosphate , sodium N , N - dioctanoylhomocystine dimethyl ester ; carnosine and borate , sodium metaborate , and potassium citrate . its derivatives and salts ; homocarnosine and its derivatives Particularly , the cosmetic lotions containing the external and salts ; anserine and its derivatives and salts ; carcinine dermal composition of the present invention are particularly 55 and its derivatives and salts ; dipeptides or tripeptide deriva desirably used in combination with one or more buffers tives and their salts containing histidine and / or triptophan selected from sodium citrate , glycolic acid , succinic acid , and /or histamine ; flavonoids such as flavanone , flavone , disodium hydrogen phosphate , sodium dihydrogen phos - anthocyanin , anthocyanidin , flavonol, quercetin , quercitrin , phate , sodium hydroxide , and potassium hydroxide in an myricetin , fisetin , hamamelitannin , catechin , epicatechin , amount sufficient for adjusting the cosmetic lotions , usually , 60 gallocatechin , epigallocatechin , epicatechin gallate , and epi to a pH of 5 to 9 , preferably , 6 to 8 , more preferably , 6 . 5 to gallocatechin gallate ; tannic acid , caffeic acid , ferulic acid , 7 .5 . protocatechuic acid , chalkone , orizanol, carnosol, sesamol , (Face - Washes ) sesamin , sesamolin , zingerone , curcumin , tetrahydrocur The external dermal composition of the present invention cumin , clovamide ( caffeoyldopa ) , deoxyclovamide , can be made into face -washes by compounding therein 65 shogaol, capsaicin , vanillamide, ellagic acid , bromphenol, ingredients having a detergent action . Face -washes are used flavoglaucin , melanoidin , riboflavin , riboflavin butyrate , almost every day for keeping the skin clean by washing riboflavin mononucleotide , flavin adenine dinucleotide, US 10 , 111 , 822 B2 41 42 ubiquinone , ubiquinol, mannitol, bilirubin , cholesterol, tosamine , hydroquinone B - L - galactosamine, hydroquinone ebselen , selenomethionine , ceruloplasmin , transferrin , lac a - D -glucuronic acid , hydroquinone B - D - glucuronic acid , toferrin , albumin , superoxide dismutase , catalase , gluta - hydroquinone a - L - glucuronic acid , hydroquinone B - L - glu thione peroxidase , metallothionein , thioredoxin , thiotaurine , curonic acid , hydroquinone a - D - galacturonic acid , hydro O - phosphono pyridoxyliden rhodamine, and N - ( 2 - hyroxy - 5 quinone B - D - galacturonic acid , hydroquinone a - L - galactur benzyl) amino acid , and their derivatives and salts ; N - ( 4 - onic acid , and hydroquinone B - L - galacturonic acid ; pyridoxylmethylene ) amino acid , and its derivatives and tranexamic acid and its derivatives and salts ; resorcin and its salts ; and others such as lysine , 1 -methionine , proline , derivatives such as 4 - n - butylresorcinol; kojic acid and its silymarin , tea extract , grape bark / seed extract, melanin , and derivatives and salts ; ellagic and linoleic acids and their rosemary extract. 10 salts ; plant extracts such as Pimpinella anisum extract, ( Other Ingredients ) Japanese knotweed extract, Daphne pseudomezereum In the face -washes can be further incorporated one or extract, Senna obtusifolia extract , seed extract of Cassia more ingredients selected from glycerin , ethanol, sugar obtusifolia L . , root extract of Astsagalusu mambranaceus ( sucrose ) , polyalcohols , and bactericides. The antiseptics Bge , Astsagalusu mambranaceus Bge extract, Trichosanthes and bactericides that are disclosed in detail in the section of 15 laceribracteata extract, Xanthium strumarium extract, Gas the above -mentioned cosmetic lotions can be appropriately trodia elata extract, Pyracantha fortuneana fruit extract, used as the bactericides ; however, chlorhexidine hydrochlo - Polygonum sachalinense Fr. Schm extract, Lindera strych ride, isopropyl methylphenol, photosensitizing dye 101, nifolia F . Vill extract, Cucurbita ( pumpkin ) extract, Typha cresol, chloroxylenol, trichlorocarbanilide , halocarban , phe - latifolia L . extract, Euphorbia kansui Liou extract , Agrimo nol, chlorocresol , phenoxyethanol, and trichlorohydroxydi- 20 nia pilosa Ledeb . var. japonica (Miq .) Nakai extract , Lin phenyl ether can be preferably used in soap - type detergents dera umbellata extract, Saxifraga fusca var. kikubuki such as face -washes for the purpose of disinfection , steril extract, Agave sisalana extract, Clematis chinensis extract, ization , and deodorant. Clematis chinensis Osbeck extract, Cerasus speciosa ( Serums) (Koidz . ) H . Ohba extract, Cerasus sargentii (Rehder ) H . The external dermal composition of the present invention 25 Ohba extract , Prunus incisa Thunb extract , Prunus nip can be made into serumsby incorporating thereunto humec - ponica extract, Cerasus subhirtella (Miq . ) S . Y . Sokolov tants and emollients . In general, unlike cosmetic lotions, extract , Prunus lannesiana Wilson extract , Aster tataricus serums are the types of cosmetics having appropriate vis - extract, Trachycarpus fortunei extract, Iris florentina L . cosity and satisfactory humectancy and feeling of use , as extract , Clematis terniflora extract, Magnolia salicifolia well as having functions as moisturizers and emollients . The 30 extract , Saxifraga fortunei var. incisolobata extract, Oeno above -mentioned humectants and emollients disclosed in thera tetraptera extract, dried seed extract of Convolvu the section of cosmetic lotions can be appropriately used . laceae / Cuscuta chinensis Lam . /C . Japonica Choisy, Cus The forms of serums are known as solubilized forms, O / W cuta australis extract, Cuscuta japonica Choisy extract , emulsion forms, and oil - liquid forms. Artemisia absinthium extract , Achillea alpina L . extract , In general, most of serums are those which advocate an 35 Dictamnus albus extract , Anethum graveolens L . extract , emphasis on functions other than their functions as mois - Reynoutria japonica var. terminalis extract , Tribulus ter turizers and emollients by further incorporating one or more restris extract , Pyrrosia lingua ( Thunb .) Farw extract, Typha ingredients selected from flavors , ultraviolet absorbing domingensis extract, root extract of Angelica dahurica , agents , skin -whitening agents , anti - inflammatories , antisep floral blanca extract , hamula (Brickellia cabanillesy ) extract, tics , and bactericides . Among the above ingredients , appro - 40 Artemisia fukudo Makino extract , Convolvulus arvensis priately usable are, for example , flavors , ultraviolet absorb - extract, Santalum album extract, Ganoderma lucidum ing agents , antiseptics , and bactericides , all of which are extract, Leonurus japonicus Houtt extract, Salix gilgiana disclosed in the section of the above -mentioned cosmetic Seemen extract, Salix chaenomeloides Kimura extract, Salix lotions . The following skin - whitening agents and anti - in - gracilistyla extract, Salix integra extract , Salix kinuyanagi flammatories can be appropriately used as examples of the 45 Kimura extract , Salix koriyanagi Kimura extract, Salix mat following skin -whitening agents and anti - inflammatories . sudana Koidz . var. tortuosa Vilm extract , Salix reinii Fr. et (Skin -Whitening Agents ) Sav extract , Salix sieboldiana extract , Toisusu urbaniana Examples of the skin -whitening agents include alkox Kimura extract , Salix viminalis/ Salix longifolia extract, ysalicylic acid and the like as well as salts thereof such as Salix vulpina Anderss extract, Populus maximowiczii A . 3 -methoxysalicylic acid , 3 - ethoxysalicylic acid , 4 -methox - 50 Henry extract, dried bark extract of Myrica rubra , Agave ysalicylic acid , 4 - ethoxysalicylic acid , 4 -propoxysalicylic americana var. marginata extract, Agave americana extract, acid , 4 - isopropoxysalicylic acid , 4 -buthoxysalicylic acid , Agave americana var. marginata extract, Edgeworthia papy 5 -methoxysalicylic acid , 5 -ethoxysalicylic acid , and rifera Sieb . et Zucc extract, Enteromorpha sp . extract , 5 -propoxysalicylic acid ; hydroquinone and derivatives Enteromorpha linza /compressa extract , Enteromorpha pro thereof including hydroquinone and its glycosides such as 55 lifera extract , Enteromorpha compressa (Linnaeus ) Nees uronic acid glycosides, for example , hydroquinone, arbutin , extract, Ulva intestinalis Linnaeus extract, Ulva Linnaeus A -arbutin , hydroquinone a -L - glucose , hydroquinone B - L - extract, Laminaria extract , Laminaria Japonica Areschoug glucose , hydroquinone a - D - galactose , hydroquinone B - D - extract, Laminaria ochotensis extract, Laminaria religiosa galactose , hydroquinone a - L - galactose , hydroquinone B -L - Miyabe extract , Laminaria angustata extract , Undaria pin galactose , hydroquinone a - D - ribose , hydroquinone B - D - 60 natifida extract , Undaria undarioides extract, Undaria ribose , hydroquinone a - L - ribose , hydroquinone B - L -ribose , peterseniana extract, Sargassum fusiforme extract , Fucus hydroquinone a - D -arabinose , hydroquinone B - D -arabinose , evanescens C . Agardh ( F . vesiculosus ) extract , Padina arbo hydroquinone a - L - arabinose, hydroquinone ß - L - arabinose , rescens extract, Padina australis Hauck extract, Padina hydroquinone a -D - glucosamine , hydroquinone B - D -glu - australis Hauck var. cuneata Tak . Tanaka et K . Nozawa cosamine , hydroquinone Q - L - glucosamine, hydroquinone 65 extract , Padina boryana Thivy extract , Padina crassa B - L - glucosamine , hydroquinone a - D - galactosamine , hydro - Yamada extract , Padina japonica Yamada extract, Padina quinone B - D -galactosamine , hydroquinone a - L - galac minor Yamada extract, Padina stipitata Tak . Tanaka et K . US 10 , 111, 822 B2 43 44 Nozawa extract , Eucheuma serra ( J . Agardh ) J . Agardh rophene, mercuric oxide , mercurychloride, hydrogen perox extract, Eucheuma amakusaense Okamura extract , Euch ide , zinc peroxide , 2 - aminophenol and derivatives thereof, euma denticulatum ( Burman ) Collins et Hervey extract, ferulic acid and derivatives thereof, placenta extract, gluta Eucheuma arnoldii Weber -van Bosse extract , Chondrus thion , orizanol, and butylresorcinol. ocelatus Holmes extract, Chondrus verrucosus Mikami 5 Examples of the anti - inflammatory agents , which can be extract, Chondrus nipponicus Yendo extract , Chondrus pin - incorporated into the serums of the present invention , nulatus (Harvey ) Okamura extract , Gigartinales Schmitz include ingredients such as extracts derived from plants and extract, Chondracanthus teedii extract , Chondracanthus mixtures thereof, for example , derivatives of propionic acid intermedius extract , Dictyopteris latiuscula extract , Dic - including betamethasone dipropionate , clobetasol propi tyopteris polypodioides extract, Sphaerotrichia divaricata 10 onate , fluticasone propionate , hydrocortisone - 21 - propi ( C . Agardh ) Kylin extract , Cymathaere extract, Cymathaere onate , hydrocortisone cyclopentyl propionate , and beclom japonica extract, Sargassum hemiphyllum Agardh extract, ethasone dipropionate ; allantoin or derivatives thereof such Sargassum segii extract , Sargassum filicinum extract, Sar - as allantoin , allantoin acetyl- dl- methionine , allantoin chlo gassum sagamianum extract , Sargassum nigrifolium extract , rohydroxy aluminum , dihydroxyaluminium allantoin , and Sargassum piluliferum ( Turner ) C . Agardh extract , Sargas - 15 allantoin polygalacturonic acid ; glycyrrhetinic acid or sum tosaense Yendo extract, Sargassum patens C . Agardh derivatives thereof such as glycyrrhetinic acid , glycyr extract, Sargassum thunbergii (Mertens ex Roth ) Kuntze rhizinic acid , allantoin glycyrrhetinate , glyceryl glycyrrhe extract, Sargassum ringgoldianum Harvey ssp . Ringgold - tinate , stearyl glycyrrhetinate , glycyrrhetinyl stearate , diso ianum extract, Grateloupia filicina (Lamouroux ) C . Agardh dium 3 - succinyloxy glycyrrhetinate , dipotassium extract, Halymenia agardhii extract , Sebdenia polydactyla 20 glycyrrhizinate, and monoammonium glycyrrhizinate ; pan extract, Grateloupia acuminata Holmes extract, Polyopes tothenic acid derivatives such as pantothenic acid , pantoth affinis (Harvey ) Kawaguchi et Wang extract, Gracilaria enyl alcohol, pantothenyl ethyl ether , benzoylpantothenyl gagas extract , Ceratodictyon spongiosum Zanardini extract, ethyl ether, calcium pantothenate , sodium pantothenate , Lomentaria catenata Harvey extract , Lomentaria pinnata acetylpantothenyl ethyl ether , pantothenyl ethyl ether ben Segawa extract, Lomentaria pinnata Segawa extract, Lau - 25 zoate , and pantethine ; tocopherol derivatives such as a -to rencia intermedia Yamada extract , Laurencia undulata copherol, B - tocopherol, y - tocopherol, tocopherol nicotinate , extract, Laurencia pinnata Yamada extract, Laurencia tocopherol acetate , tocopherol linoleate , tocopherol ferulate , brongniartii J. Agardh extract , Odonthalia corymbifera and tocopherol phosphate ; vitamin E and derivatives thereof (Gmelin ) Greville extract , Tilia extract, Camotede azafran such as tocotrienol, vitamin E acetate , and tocopherol suc extract, Hibiscus spp . extract, Poleoverde verde extract , 30 cinate ; 2 - aminophenol and derivatives thereof; acetic acid Raphanus sativus extract, Sargassum confusum C . Agardh derivatives such as sulindac, diclofenac , and fenbufen ; pyri extract, Sargassum kjellmanianum Yendo extract , Sargas doxine hydrochloride, menthol, biotin , camphor , turpentine , sum macrocarpum C . Agardh extract, Perilla frutescens var . zinc oxide , azulene, guaiazulene , and derivatives thereof ; crispa extract, placenta extract, “ RUSINOL ” ( 4 - n -butylre - mefenamic acid and derivatives thereof; fenamic acid and sorcinol) , silk extract , Acacia Mill extract, Malpighia glabra 35 derivatives thereof; phenylbutazone and derivatives thereof; extract, Abutilon avicennae extract , Betula pendula extract, indometacin and derivatives thereof; ibuprofen and deriva Quercus ( gallnut ) extract, Castanea crenata extract, Isodon tives thereof ; biphenylcarboxylic acid derivatives ; oxicam , umbrosus var. leucanthus f . kameba extract, Isodon salicylic acid , acetylsalicylic acid , naproxen , benoxaprofen , trzichocarpus extract, Rabdosia japonica (Burm . fil. ) H . flurbiprofen , fenoprofen , indoprofen , pirprofen , carprofen , Hara extract, Oenanthe javanica extract, Fagopyrum escu - 40 oxaprozin , pranoprofen , microprofen , tioxaprofen , supro lentum extract, Durvillaea antarctica extract , Capsella profen , alminoprofen , tiaprofenic acid , fluprofen , ketopro bursa -pastoris extract, Eupatorium japonicum extract, fen , and derivatives thereof; e -aminocaproic acid , diclofenac Moraceae extract , Gardenia jasminoides extract , Angelica sodium , diphenhydramine , tranexamic acid , and derivatives acutiloba extract , Sanguisorba officinalis extract, Sophora thereof; cortisone and esters thereof; hydrocortisone and flavescens extract , Artemisia indica var. maximowiczii 45 esters thereof, adrenal cortical hormones such as prednisone extract , Lonicera japonica extract, Phellodendron amurense and prednisolone ; and others such as antihistamine , bucloxic extract, Houttuynia cordata extract, Poria cocos extract, acid , apazone , bromfenac , celecoxib , difenpiramide , difluni Coix lacryma - jobi var. ma - yuen extract, Lamium album L . sal, etodolac , flufenamic acid , ketorolac , meclofenamate , var . barbatum extract, Humulus lupulus extract, Crataegus mefenamic acid , meloxicam , nabumetone , piroxicam , cuneata extract , Eucalyptus extract, Achillea millefolium 50 butibufen , rofecoxib , tolmetin , ketorolac tromethamine , extract, Althaea extract, Cinnamomum loureiri Nees extract , chlorpheniramine , diphenhydramine hydrochloride , chlo Vitex rotundifolia L . fil. extract, Hamamelis virginiana rpheniramine maleate, corticosteroid , alclometasone , dex extract , Morus australis extract , Platycodon grandiflorum amethasone , flumetasone , hydrocortisone , hydrocortisone extract, Euphorbia lathyris L . extract, Iris japonica extract, 21 -monoester , hydrocortisone 21 - acetate, hydrocortisone Ephedra intermedia extract , Cnidium officinale Makino 55 21- butylate , hydrocortisone 21 - valeate , hydrocortisone extract, Aralia cordata extract , Bupleurum / Eryngium 17 , 21 -diester , hydrocortisone 17 ,21 - diacetate , hydrocorti extract, Saposhnikovia divaricata extract , Glehnia littoralis sone 17 -acetate 21 -butylate , hydrocortisone 17 ,21 -dibuty extract , Scutellaria baicalensis extract, peony root bark late , methylprednisolone, betamethasone benzoate , diflora extract, Paeonia lactiflora Paeonia extract , Geranium thun - sone diacetate, fluocinonide , mometasone furoate , topical bergii extract, Pueraria lobata extract , Glycyrrhiza uralen - 60 corticosteroid , hydroxytriamcinolone , a -methyldexametha sis root extract , Rhus javanica extract , Aloe barbadensis sone , dexamethasone phosphate , clobetasol valerate , des Miller extract Cimicifugae rhizoma extract , Carthamus tinc onide , desoximetasone , desoxycorticosterone acetate , torius extract, green tea extract, red tea extract , Uncaria dichlorisone , diflorasone diacetate , diflucortolone valerate , gambir extract , Matricaria recutita extract , Persicaria tinc - fluadrenolon , fluclorolonacetonid , fludrocortison , flumeta toria extract , oil - soluble Glycyrrhiza glabra ( licorice ) root 65 sone pivalate , fluosinolonacetonid , fluocortin butyl ester, extract, Cacumen Tamaricis extract, and Saxifraga stolo fluocortolone, fluprednidene ffluprednylidenejacetate , flu nifera extract ; and others such as phenylmercury hexachlo - randrenolone, halcinonide , hydrocortisone acetate , hydro US 10 , 111 , 822 B2 45 46 cortisone butyrate , triamcinolone acetonide, cortodoxone , the blood circulation in the skin . Milky lotions are also flucetonide, medrysone , amciafel , amcinafide , betametha called “ liquid creams” because , except in a special case , they sone , chloroprednisone , chloroprednisone acetate , clo - have a lesser amount of oil phase than creams and are cortelone, clescinolone , difluprednate , flucloronide , fluni free - flowing emulsions. There are two types of O / W and solide , fluperolone, fluprednisolone , hydrocortisone 5 W / O emulsions, of which the former is general and capable valerate , hydrocortamate , meprednisone , paramethasone , of imparting a moistened feeling to users because it has a triamcinolone , isoxicam , tenoxicam , sudoxicam , CP - 14 , relatively high ratio of water phase and spreads thinly , when 304 , Aloe barbadensis Miller , Aloe vera L ., plant sterol, applied to the skin . Examples of appropriately employable phytosterol, Polygonum tinctorium , Uncaria gambir Roxb , oily ingredients and surfactants include those which are Hydrangea macrophylla var. thunbergii, Althaea officinalis , 10 disclosed in detail in the above section of cosmetic lotions. Arnica montana L , Aloe barbadensis Miller, Polygonum One or more ingredients selected from humectants , emol bistorta L ., Urtica thunbergiana , Rosa multiflora , Echina - lients , blood circulation accelerators, and high molecular cea , Rabdosia japonica , Curcuma longa , Scutellaria baical- substances can be incorporated in the milky lotions accord ensis Georgi, Hordeum vulgare , Hypericum erectum , Citrus ing to the present invention , depending on their purposes and sinensis , Valeriana fauriei Brig . , Betula , Matricaria chamo - 15 functions, in a respective amount of at least 0 .0001 % by milla L ., Daucus carota , Artemisia capillaris , Glycyrrhiza mass , preferably , 0 . 001 to 50 % by mass , more preferably , uralensis , Cucumis sativus L ., Lonicera japonica , Commi- 0 .01 to 25 % by mass , and more preferably , 0 . 1 to 10 % by phora ( guggal] , Gardenia jasminoides, Sasa veitchii, Nas- mass to the mass of each of the milky lotions. Examples of turtium officinale , Gentiana lutea Linn , Geranium thunber such humectants and emollients include those which are gii , Cola , Arctium lappa L ., Symphytum officinale , 20 disclosed in detail in the above section of cosmetic lotions. Acanthopanax senticosus Harms, Scrophularia buergeriana Examples of the blood circulation accelerators and high Miq ., Salvia splendens, Zanthoxylum piperitum , Corian - molecular substances include the following ones to be drum sativum L ., Lithospermum erythrorhizon , Perilla frute appropriately incorporated into the milky lotions . scens var. crispa , Paeonia lactiflora , Betula platyphylla var. (Blood Circulation Accelerators ) japonica , Salvia officinalis , Hypericum perforatum , Hedera 25 Examples of the blood circulation accelerators include helix , Juniperus communis , Achillea millefolium , Mentha plant substances such as Swertia japonica , Asian ginseng piperita L ., Cnidium officinale Makino , Swertia japonica , [Panax ginseng ], Ginkgo biloba , Urtica thunbergiana , Zin Morus alba , Ziziphus jujuba , Thymus L . , Coriandrum sati giber officinale , Allium sativum , Angelica keiskei, Arnica vum , Centella asiatica Urban , Benincasa hispida , Amygd - montana , Prunus armeniaca , Foeniculum vulgare, Trillium alus persica L ., Houttuynia cordata , Potentilla tormentilla , 30 apetalon , Hypericum erectum , Ononis spinosa , Nasturtium Poligonum tinctorium Lour, Camellia sinensis , Angelica officinale , Chaenomeles sinensis , Matricaria chamomilla L . , acutiloba , Calendula officinalis, Sambucus racemosa subsp . Anthemis nobilis, Rubus palmatus, Cinchona Succirubra L ., sieboldiana , Daucus carota L . [ carrot ] , Petroselium Papaver rhoeas L . , Sophora flavescens , Gentiana lutea , crispum , Mentha , Santalum album , Eriobotrya japonica , Cinnamomum cassia Blume, Nuphar japonicum , Arctium Aesculus hippocastanum , Vitis labrusca , Brassica oleracea 35 lappa L ., Oryzasativa , Salvia , Zanthoxylum piperitum , Cra var . italica , Carthamus tinctorius , Typha angustifolia , Tilia taegus cuneata , Lentinula edodes , Rehmannia glutinosa ( R . miqueliana , Paeonia suffruticosa , Manjistha , Aesculus hip - glutinosa var. purpurea ), Diospyros spp ., Paeonia lactiflora , pocastan , Sapindus mukorossi, Ellisella sp . extract, Trades - Zingiber officinale , Acorus calamus var . angustatus , Cra cantia ohiensis , Oenothera biennis , Amygdalus persica L ., taegus oxyacantha var. paulii, Aesculus hippocastanum L . , Rodgersia podophylla , Eucalyptu , Artemisia indica var. 40 Juniperus communis , Ligusticum chuanxiong, Citrus auran maximowiczii, Myrica rubra , Lavandula vera , Anthemis tium , Thymus spp ., Syzygium aromaticum , Capsicum nobilis , and Rosmarinus officinalis L . annuum , Angelica sinensis ( Oliv . ) Diels , Calendula offici In particular , in the case of serums in which the external nalis Linn , Prunus persica (L .) Batsch , Picea , Houttuynia dermal composition of the present invention is incorporated , cordata , Juniperus oxycedrus Linne , Mentha spp ., Glehnia the following one or more ingredients of natural ingredients 45 littoralis , Hamamelis virginiana , Ruscus aculeatus L ., Vitis can be used alone or in combination as anti - inflammatory spp . , Tilia miqueliana Maxim , Humulus lupulus, Paeonia agents ; glycyrrhetic acid and derivatives thereof such as suffruticosa , Pinus luchuensis , Aesculus hippocastanum , stearyl glycyrrhetinate and dipotassium glycyrrhizate ; and Rosmarinus officinalis , Melissa officinalis , Melilotus offci others of Gentiana lutea root extract, Perilla frutescens nalis , Citrus junos, Eriobotrya japonica , Coix lachryma - jobi extract, Salvia officinalis extract , Sambucus nigra L . extract, 50 L . ma -yuen Stapf, Lavandula angustifolia , Gentiana scabra Centella asiatica extract , Houttuynia cordata extract , var. buergeri, Rosmarinus officinalis , Rosa canina , peel of Angelica sinensis extract , Paeonia suffruticosa extract , Citrus unshiu Markovich , Prunus persica , Juglans mand Oenothera biennis extract , Sapindus mukorossi extract, shurica subsp . sieboldiana , Equisetum arvense L ., root of Saxifraga stolonifera extract , Artemisia indica var. maximo Acorus calamus, Aloe barbadensis Miller , Myrica rubra , wiczii extract, and Malus pumila extract. Usually , the above 55 Eucalyptus regnans, and Artemisia princeps Pampan ; hes ingredients are respectively incorporated into the serums in peridin ; glycosyl hesperidin ; rutin ; glycosyl rutin ; acetyl an amount of at least 0 .0001 % by mass, preferably , 0 . 001 to choline ; capronium chloride ; diphenhydramine hydrochlo 50 % by mass, more preferably, 0 .01 to 25 % by mass, and ride; y -oryzanol ; 1- menthol ; cepharanthine; methyl more preferably , 0 . 1 to 10 % by mass to the mass of each of nicotinate ; vitamin E and derivatives thereof such as d - to the serums according to the present invention . 60 copherol, a - tocopherol, tocopherol acetate , tocopheryl
As found in Table 14 , the aqueous solution prepared by 15 total amount of 100 g each and to obtain gels with pHs of dissolving the anhydrous crystalline sodium salt of ascorbic around 6 .5 . Twenty grams of “ AA2G ” , a product name of a acid 2 -glucoside alone in water had a pH of 13. 1 , while the particulate composition containing anhydrous crystalline aqueous solution prepared by dissolving the powder con - ascorbic acid 2 - glucoside , commercialized by Hayashibara taining anhydrous crystalline ascorbic acid 2 - glucoside 20 Co . , Ltd . , Okayama, Japan , was dissolved in 100 g of water alone in water had a pH of 1 .7 . The aqueous solutions of the and prepared into a solution with a total mass of 164 . 7 g , compositions of the anhydrous crystalline sodium salt of called “ neutralized aqueous solution of ascorbic acid 2 - glu ascorbic acid 2 - glucoside and the particulate composition coside” , hereinafter , by neutralizing the ascorbic acid 2 -glu containing anhydrous crystalline ascorbic acid 2 - glucoside coside with the addition of 20 g of citric acid buffer , exhibited pHs in the range of 12 . 9 to 2 . 6 depending on their 25 containing 1 % by mass of citric acid and 15 % by mass of composition ratios . It was revealed that the aqueous solu - sodium citrate , and 24 .7 g of 10 % sodium hydroxide solu tions of ascorbic acid 2 - glucoside can be made to give tion . To 25 g of any of the gel bases was added 16 .47 g of desired pHs ranging widely from acidic pHs and alkaline the neutralized aqueous solution of ascorbic acid 2 - gluco pHs by combining sodium salt of ascorbic acid 2 - glucoside side, added with two grams of 10 % by mass of sodium and ascorbic acid 2 - glucoside in appropriate ratios , particu - 30 hydroxide solution , and supplemented with water to give a larly , when combined in ratios ranging from 55 :45 to 40 :60 , total amount of 100 g and to obtain gels with pHs of around they exhibit pHs ranging from weak alkaline to weak acidic 6 . 5 . Table 15 shows the pHs and the observations on the pHs preferable in preparing cosmetics . properties of the gels ( carbomer concentration : 0 . 5 % , ascor Experiment 14 : Effect of Sodium Salt of Ascorbic os35 DCbic acid 2 - glucoside concentration : 2 % ). Acid 2 -Glucoside on Gelatinizing Agents TABLE 15 To examine the effect of sodium salt of ascorbic acid Sodium salt of Neutralized 2 -glucoside in preparing gelatinous cosmetics, a model ascorbic acid ascorbic acid experiment for preparing gels containing ascorbic acid 40 2 - glucoside 2 - glucoside 2 -glucoside was conducted by using the nine types of carbomers , as gelling agents generally used in the field of Carbomer Gel property pH Gel property pH cosmetics , as listed in Table 15 ( five types of “ CAR CARBOPOL 940 6 . 45 6 .55 CARBOPOL 980 6 . 45 6 .50 BOPOL ” , commercialized by Nikko Chemicals Co ., Ltd ., CARBOPOL 981 6 . 37 6 .51 Tokyo , Japan ; three types of “HIBIS WAKO ” , commercial - 45 CARBOPOL ULTREZ 10 6 . 54 6 . 61 ized by Wako Pure Chemical Industries, Ltd ., Tokyo , Japan ; CARBOPOL ETD 2050 6 . 26 6 .43 one type of “ AQUPEC ” , commercialized by Sumitomo HIBIS WAKO 103 >OODODO 6 . 26 6 . 31 HIBIS WAKO 104 6 . 40 6 . 18 Seika Chemicals Company Ltd . , Osaka , Japan ), an antisep HIBIS WAKO 105 6 . 36 6 .38 tic , and ascorbic acid 2 - glucoside . The properties of gels , AQUPEC HV - 505 6 . 31 6 . 46 which had been prepared by adjusting pHs with citric acid 50 – buffers and sodium hydroxide at the step of adding ascorbic Note acid 2 - glucoside , and another gels with pHs of around 6 . 5 X : With no viscosity , but with no citric acid buffer , which had been prepared with A : With viscosity , sodium salt of ascorbic acid 2 - glucoside without employing O : With shape retainability any neutralization treatment. 55 Five grams of any of the above gelling agents and 7 . 5 g As evident from Table 15 , no gel with shape as a gel was of pentylene glycol as an antiseptic were dissolved in 237. 5 obtained even though some of the gel bases , which had been g of water into a gel base (with a concentration of 2 % by prepared by using ascorbic acid 2 - glucoside and being mass ) . The anhydrous crystalline sodium salt of ascorbic neutralized with citric acid buffer and sodium hydroxide , acid 2 -glucoside , obtained by the method in Experimentwent 60on exhibited viscosity but all the gel bases had a relatively high 12 - 1 , was dissolved in water to prepare an aqueous solution free - flowing ability . Every gel base , which had been pre containing 20 g of ascorbic acid 2 - glucoside per 250 g of the pared by using sodium salt of ascorbic acid 2 - glucoside , aqueous solution (called “ aqueous solution of sodium salt of retained viscosity and kept shape as a gel . These results ascorbic acid 2 - glucoside ” , hereinafter ) . To 25 g of each of indicate that the use of sodium salt of ascorbic acid 2 - glu the gel bases was added 25 g of the aqueous solution of 65 coside relatively easily facilitates the production of gelati sodium salt of ascorbic acid 2 -glucoside , and the resulting nous cosmetics , which could not have been easily prepared solutions were respectively admixed with water to give a with ascorbic acid 2 - glucoside . US 10 , 111 , 822 B2 77 78 Experiment 15 : Anti - Wrinkle Action of Cosmetic allowed to use any one of cosmetic lotions 1 to 3 twice a day Lotion ( both in the morning and evening ) for successive four weeks. During the test period of time, the subjects were so A volunteer test on anti- wrinkle action was carried out instructed as to spend their usual daily life , except for using three types of cosmetic lotions , i. e . , cosmetic lotion 1 5 avoiding the use of cosmetics proclaiming any improvement with no ascorbic acid 2 - glucoside ( control) ; cosmetic lotion of wrinkles . After completion of the test period of time, all 2 prepared by incorporating “ AA2G ” , a product name of a the subjects were received a questionnaire about the particulate composition containing anhydrous crystalline improvement of wrinkles and fine wrinkles, the improve ascorbic acid 2 - glucoside, commercialized by Hayashibara ment of skin firmness and elasticity , and the feeling of use . Co ., Ltd . , Okayama, Japan , in an amount of two percent by 10 The numbers of subjects , who answered “ it exerted an mass , along with sodium hydroxide as a neutralizer and improved effect” on wrinkles and fine wrinkles , as well as citric acid plus sodium citrate as pH - regulators ; and cos skin firmness and elasticity ; and " the feeling of use was metic lotion 3 prepared by incorporating a particulate com - satisfactory ” , were tabulated in Table 17 . position containing anhydrous crystalline sodium salt of 10 ascorbic acid 2 - glucoside obtained by the later described 15 TABLE 17 method in Example 2 in an amount of two percent by mass Cosmetic without employing any neutralization treatment. lotion 1 Cosmetic Cosmetic Cosmetic lotion 1 : It was prepared by dissolving the ingre Evaluation item dients ( 1 ) and ( 4 ) to ( 7 ) in Table 16 in refined water ( 14 ) to . ( Control ) lotion 2 lotion 3 obtain a water phase, mixing the water phase with a solution Improvement of wrinkles Improvement of fine wrinkles prepared by dissolving polyoxyethylene oleyl alcohol ( 8 ) Improvement of skin firmness and flavor ( 10 ) in ethanol (9 ) , and adjusting the resulting and elasticity wNNE mixture to pH 6 . 5 with an adequate amount of sodium Satisfactory feeling of use hydroxide . Cosmetic lotion 2 : It was prepared similarly as in cosmetic 25 lotion 1 except for dissolving the ingredients ( 1 ) and ( 4 ) to As evident from Table 17, the number of subjects with ( 7 ) in Table 16 in a part of refined water ( 14 ) ; dissolving in cosmetic lotion 1, who answered “ it exerted an improved the aqueous solution “ AA2G ” , a product name of a particu effect" on wrinkles and fine wrinkles, was two out of ten ; at late composition containing anhydrous crystalline ascorbic least six out of ten with cosmetic lotion 2 or 3 answered " it acid 2 -glucoside , commercialized by Hayashibara Co . , Ltd ., 30 exerted an improved effect" . As for the feeling of use , three Okayama, Japan ; neutralizing the resulting mixture with out of ten with cosmetic lotion 1 answered “ Satisfactory ” , sodium hydroxide ; adjusting the mixture to pH 6 . 5 by the while five with cosmetic lotion 2 and seven with cosmetic addition of citric acid ( 11 ) and sodium citrate ( 12 ) as lotion 3 answered “ Satisfactory ” . During the test period of pH -regulators ; and adding the remaining refined water to the of time, there was no subject with any induced skin problem , mixture to obtain a water phase . revealing that all the cosmetic lotions were harmless . The Cosmetic lotion 3 : It was prepared similarly as in cosmetic above results indicate that cosmetic lotions with ascorbic lotion 1 except for using a particulate composition contain acid 2 - glucoside or sodium salt thereof have more advan ing anhydrous crystalline sodium salt of ascorbic acid 2 - glu - tageous effects of improving wrinkles and fine wrinkles and coside as sodium salt of ascorbic acid 2 - glucoside ( 3 ), which 20 imparting firmness and elasticity to the skin , compared to had been prepared by the later described method in Example cosmetic lotions with no ascorbic acid 2 - glucoside . 2 , and adjusting the lotion to pH 6 . 5 . Experiment 16 : Anti- Blemish and Anti -Freckle TABLE 16 Action of Milky Lotion Cosmetic 45 lotion 1 Cosmetic Cosmetic Based on the formulation in Table 18 (numerals are Ingredient ( Control) lotion 2 lotion 3 expressed based on % by mass ) , three types ofmilky lotions ( 1 ) Sorbitol (emollient lotions ), i. e . , milky lotion 1 with no ascorbic acid ( 2 ) Ascorbic acid 2 - glucoside 2 - glucoside (Control ) ; milky lotion 2 prepared by incorpo ( 3 ) Sodium salt of ascorbic Oo 50 rating “ AA2G ” , a product name of a particulate composition acid 2 - glucoside containing anhydrous crystalline ascorbic acid 2 - glucoside , ( 4 ) Dipropylene glycol ONbio commercialized by Hayashibara Co. , Ltd ., Okayama, Japan , ( 5 ) Polyethylene glycol 1500 in ( 6 ) Methyl cellulose 0 . 2 in an amount of three percent by mass , and neutralizing and ( 7 ) Quince seed 0 . 1 0 . 1 adjusting the resultant to a prescribed pH with sodium ( 8 ) Polyoxyethylene oleyl alcohol 0 . 5 0 . 5 55 hydroxide ; and milky lotion 3 prepared by incorporating a ( 9 ) Ethanol 5 particulate composition containing anhydrous crystalline ( 10 ) Flavor q . s . q . s . ( 11 ) Citric acid 0 .01 sodium salt of ascorbic acid 2 - glucoside in an amount of ( 12 ) Sodium citrate 0 . 15 three percent by mass without employing any neutralization ( 13 ) Sodium hydroxide qooo q . s . q . s . treatment, which were then subjected to a volunteer test on (14 ) Refined water Remaining Remaining Remaining 60 the action of anti- blemishes and anti- freckles . Milky lotion 1 : The ingredients ( 7 ) to ( 9 ) and ( 14 ) in Table Cosmetic lotion 1 ( Control ), cosmetic lotion 2 , and cos- 18 were added to refined water ( 15 ), mixed while heating , metic lotion 3 obtained in the above were respectively and adjusted with sodium hydroxide to give a pH of 7 .0 to examined for anti -wrinkle action and anti - fine -wrinkle make it into a water phase . The ingredients ( 1 ) to ( 5 ) in Table action . Thirty female subjects , 37 - to 55 -year - old , suffering 65 18 were heated to 70° C . to make it into an oil phase from wrinkles and fine wrinkles , were randomly divided into separately . The oil phase was added to the water phase , three groups with ten subjects each , which were respectively emulsified preliminary, emulsified to homogeneity with a US 10 , 111, 822 B2 79 80 homomixer, cooled , and added with triethanolamine (6 ), As shown in Table 19, one out of ten subjects with milky carboxyvinylpolymer ( 10 ), and flavor ( 11 ) to obtain a milky lotion 1 (Control ) answered that blemishes and freckles were lotion . “ Improved ” , and two out of ten subjects answered “ Slightly Milky lotion 2 : It was similarly prepared as in milky lotion improved ” , while at least seven out of ten subjects with 1 except for finally adding the following solution prepared 5 milky lotion 2 or 3 answered “ Improved ” or “ Slightly by using “ AA2G ” , a product name of a particulate compo improved ” . During the test period of time, there was no sition containing anhydrous crystalline ascorbic acid 2 - glu subject with any induced skin problem , revealing that these coside , commercialized by Hayashibara Co ., Ltd ., milky lotions are harmless. The above results indicate that Okayama, Japan , as ascorbic acid 2 - glucoside (12 ) , dissolv milky lotions with ascorbic acid 2 - glucoside or sodium salt ing the particulate composition in a part of refined water thereof have a more advantageous effect of improving ( 14 ) , adding sodium hydroxide ( 14 ) , and neutralizing and blemishes and freckles compared to the milky lotions with adjusting the resulting mixture to pH 7 . 0 . no ascorbic acid 2 -glucoside . Milky lotion 3 : It was similarly prepared as in milky lotion 1 except for finally adding the following solution prepared Experiment 17 : Anti- Sagging Skin Effect of Face by using a particulate composition containing anhydrous 15 Wash crystalline sodium salt of ascorbic acid 2 -glucoside prepared Based on the formulation (numerals are expressed based by the method in Example 2 as sodium salt of ascorbic acid on % by mass ) shown in Table 20 , three types of face washes 2 -glucoside ( 13 ), dissolving the particulate composition in a (cleansing creams) , i .e ., face wash 1 (Control ) with no part of refined water ( 14 ) , and adjusting the resulting solu - 20 ascorbic acid 2 - glucoside, face wash 2 prepared by incor tion to pH 7 . 0 . porating “ AA2G ” , a product name of a particulate compo sition containing anhydrous crystalline ascorbic acid 2 - glu TABLE 18 coside, “ AA2G ” , a particulate composition containing Milky anhydrous crystalline ascorbic acid 2 - glucoside , commer lotion 1 Milky Milky cialized by Hayashibara Co ., Ltd ., Okayama, Japan , in an Ingredient ( Control) lotion 2 lotion 3 amount of two percent by mass and using potassium hydrox ( 1 ) Stearic acid 3. 5 3 . 5 3. 5 ide as a neutralizer and pH - regulator, and face wash 3 ( 2 ) Cetanol ? 0. 5 0 . 5 prepared by incorporating an anhydrous crystalline particu ( 3 ) Lanolin ? 0 .5 late composition of sodium salt of ascorbic acid 2 - glucoside ( 4 ) Petrolatum 3 3 30 ( 5 ) Squalane obtained by the later described method in Example 3 in an (6 ) Triethanolamine amount of two percent by mass without using any pH ( 7 ) Propylene glycol q .s . q. S. q .s . regulator, all of which were subjected to a volunteer test on ( 8 ) Sorbitol (70 % ) CONNWNWOOW2 2 anti - sagging skin action . ( 9 ) 1 , 2 - Pentane diol Face wash 1 : A water phase was prepared by dissolving the ( 10 ) 1 % Carboxyvinyl polymer 35 ( liquid neutralized with alkali ) Smareemcincoanomo ingredients (11 ) to (13 ) in Table 20 in refined water ( 14 ). The ( 11) Flavor q .s . 9 . s . water phase was gradually added , while stirring, to an oil ( 12 ) Ascorbic acid 2 -glucoside ?? phase which had been prepared by mixing the ingredients ( 13 ) Sodium salt of ascorbic ( 1 ) to ( 8 ) in Table 20 , melted , and adjusted to 70° C . , and the acid 2 - glucoside | ( 14 ) Sodium hydroxide q . s . q . s . 40 mixture was kept at 70° C . to terminate saponification ( 15 ) Reined water Remaining Remaining Remaining reaction . The resulting mixture was cooled to 50° C . while stirring, mixed to homogeneity , and cooled to 25° C . to obtain a face wash ( cleansing cream ) with pH 9 . 0 . The milky lotions 1 (Control ), 2 , and 3 obtained in the Face wash 2 : It was similarly prepared as in face wash 1 above were examined for anti- blemishes and anti - freckles . except for using , as ascorbic acid 2 -glucoside ( 9 ), “ AA2G ” , Thirty female subjects , 22 - to 51 -year - old , suffering from 45 a productprod name of a particulate composition containing blemishes and freckles, were randomly divided into three anhydrous crystalline ascorbic acid 2 - glucoside , commer groups consisting of 10 subjects each , who were allowed to cialized by Hayashibara Co . , Ltd . , Okayama , Japan , dissolv use any one of milky lotions 1 to 3 for successive four ing it in a part of refined water ( 14 ), neutralizing the solution weeks . During the test period of time, the subjects were so with potassium hydroxide , and mixing the resulting solution instructed as to spend their usual daily life except for 30 with the other ingredients for face wash cooled previously . avoiding the use of any cosmetic proclaiming an effect of Face wash 3 : It was similarly prepared as in face wash 1 improving blemishes and freckles. After terminating the test except for using, as sodium salt of ascorbic acid 2 - glucoside period of time, improved effects on skin blemishes and ( 10 ) , a particulate composition containing anhydrous crys freckles were judged on questionnaires. The test results are talline sodium salt of ascorbic acid 2 - glucoside obtained by in Table 19 . 55 the later described method in Example 2 , dissolving it in apart of refined water ( 14 ) , and incorporating the resulting TABLE 19 solution after cooling to the other ingredients for face wash Judgement on the action of improving without neutralizing the solution . blemishes and freckles - 60 TABLE 20 Improved Slightly improved Not improved Face wash 1 Face Face Milky lotion 1 Ingredient (Control ) wash 2 wash 3 ( Control) ^tt Milky lotion 2 ( 1 ) Stearic acid Milky lotion 3 mt 65 ( 2 ) Palmitic acid ( 3 ) Myristic acid ouco 10 10 US 10 , 111 ,822 B2 81 82 TABLE 20 -continued using any pH - regulator; all of which were subjected to a volunteer test on skin -whitening and anti - wrinkle actions . Face wash 1 Face Face Serum 1 : According to the formulation of Table 22 , the Ingredient (Control ) wash 2 wash 3 ingredients ( 1 ) to (5 ) and (12 ) to ( 18 ) were mixed , further ( 4 ) Sodium lauryl sulfate (5 ) Lauric acid diethanolamide admixed with a mixture which had been prepared by mixing ( 6 ) Lanolin the ingredients ( 9 ) to ( 11) , homogenized , and adjusted to ( 7 ) Cetanol give a pH of 6 . 5 for obtaining a serum . ( 8 ) Glycerin Serum 2 : It was similarly prepared as in serum 1 except for ( 9 ) Ascorbic acid 2 - glucoside ( 10 ) Sodium salt of ascorbic incorporating, as ascorbic acid 2 - glucoside ( 6 ) , “ AA2G ” , a acid 2 - glucoside ooaWNA ONTWNA NOWNA 10 product name of a particulate composition containing anhy ( 11 ) Potassium hydroxide q . s . q . s . q . s . drous crystalline ascorbic acid 2 - glucoside , commercialized ( 12 ) 1 , 2 -Hexane diol 1 . 5 1 . 5 1 . 5 by Hayashibara Co . , Ltd . , Okayama, Japan , in an amount of ( 13 ) Flavor q . s . q . s . Remaining Remaining Remainingq . s . three percent by mass ; and adjusting the resultant with ( 14 ) Refined water potassium hydroxide to give a pH of 6 .5 . Serum 3 : It was similarly prepared as in serum 1 except for The above -obtained face washes 1 ( Control) , 2 , and 3 incorporating , as sodium salt of ascorbic acid 2 - glucoside were examined for anti- sagging skin action . Thirty males ( 7 ) , a particulate composition containing anhydrous crystal and females, 36 - to 58 -year - old , suffering from saggings in the skin were divided into three groups consisting of 10 each line sodium salt of ascorbic acid 2 - glucoside , obtained in the to have substantially the same male - to - female ratio . To each 20 later described Example 2 ; and adjusting the resultant to subject in every group was allowed to use any one of face give a pH of 6 . 5 without employing a neutralization treat washes 1 to 3 for successive four weeks. During the test ment with potassium hydroxide . period of time, the subjects were so instructed as to spend their usual daily life , except for avoiding the use of any 25 TABLE 22 cosmetic or the like proclaiming an effect of improving Serum 1 saggings in the skin . After terminating the test period of Ingredient ( Control ) Serum 2 Serum 3 time, the subjects were asked for improved effect on sagging ( 1 ) Glycerin in the skin . The results are in Table 21 . ( 2) Dipropylene glycol 10 30 ( 3 ) Ethanol ( 4 ) Carboxyvinylpolymer 0 .2 0 .2 0 . 2 TABLE 21 ( 5 ) Sodium hyaluronate 0 . 5 0 . 5 0 . 5 ( 6 ) Ascorbic acid 2 - glucoside Judgement on the action of improving saggings in the skin ( 7 ) Sodium salt of ascorbic acid 2 - glucoside Improved Slightly improved Not improved ( 8 ) Potassium hydroxide q . s . q . s . q . s . 35 ( 9 ) Polyoxyethylene (20 moles ) 0 . 5 0. 5 0 . 5 Face wash 1 sorbitan monooleate ( Control) ( 10 ) Polyoxyethylene ( 20 moles) 1 Face wash 2 octyldodecanol Face wash 3 ntm ( 11 ) Olea europaea (olive ] oil 0 . 15 0 . 15 0 . 15 ( 12 ) Placenta extract 0 . 1 0 . 1 0 . 1 40 ( 13 ) Vitamin E acetate 0 . 1 0 . 1 0 . 1 As shown in Table 21, two out of ten subjects with face ( 14 ) Sodium hydrogen sulfite q. s . q .s q . s wash 1 (Control ) answered “ Improved ” in saggings of their ( 15 ) DETA•3Na q .s . q . s q .s skins and two out of ten subjects answered “ Slightly ( 16 ) Flavor q. s . 9 . s 9 . s ( 17) 1 , 3 -Butylene glycol q .s . q. improved ” , while eight out of ten subjects with face wash 2 Remaining Remaining Remainingq. s or 3 answered “ improved ” or “ Slightly improved ” . During 45 – ( 18 ) Refined water the test period of time, there was no subject with any skin The above -obtained serum 1 (Control ) , serum 2 , and problem , revealing that the face washes were harmless . The serum 3 were examined for skin -whitening and anti -wrinkle above results indicate that face washes with ascorbic acid actions. Thirty female subjects , 26 - to 48 -year - old , suffering 2 - glucoside or sodium salt thereof have an advantageous from dullness and wrinkles, were randomly divided into effect of improving saggings in the skin compared to face 50 threethr groups consisting of 10 each , which were respectively washes with no ascorbic acid 2 - glucoside . allowed to use any one of serums 1 to 3 for successive four weeks . During the test period of time, the subjects were so Experiment 18 : Skin -Whitening and Anti -Wrinkle instructed as to spend their usual daily life , except for Actions of Serums avoiding the use of any cosmetic or the like proclaiming a 55 skin -whitening effect and an effect of improving wrinkles . Based on the formulation ( numerals are expressed based After terminating the test period of time, the skin -whitening on % by mass ) in Table 22 , three types of serums, i. e ., serum 1 (Control ) with no ascorbic acid 2 - glucoside ; serum 2 effect and the wrinkle - improving effect in the subjects were prepared by incorporating “ AA2G ” , a product name of a evaluated on questionnaires . The test results are in Table 23 . particulate composition containing anhydrous crystalline 60 ascorbic acid 2 - glucoside, commercialized by Hayashibara TABLE 23 Co. , Ltd . , Okayama, Japan , in an amount of three percent by Judgement on skin -whitening and wrinkle - improving actions mass , and adjusting the resultant with sodium hydroxide to pH 6 .5 ; and serum 3 prepared by using a particulate com Improved Slightly improved Not improved position containing anhydrous crystalline sodium salt of 65 Serum 1 ascorbic acid 2 - glucoside obtained by the later described (Control ) Example 3 in an amount of three percent by mass without US 10 , 111, 822 B2 83 84 TABLE 23 -continued where unfavorable inconveniences are inevitably induced depending on a method of neutralizing ascorbic acid 2 - glu Judgement on skin -whitening and wrinkle - improving actions coside with an alkali . Improved Slightly improved Not improved Example 3 Serum 2 ????? Serum 3 < Cosmetic Material> Fifty five parts by mass of a particulate composition As shown in Table 23 , one out of ten subjects with serum containing anhydrous crystalline sodium salt of ascorbic 1 (Control ) answered “ Improved ” in skin - whitening and 10 acid 2 - glucoside obtained by the method in Example 2 was wrinkles , and one out of ten subjects answered “ Slightly admixed to homogeneity with 45 parts by mass of “ AA2G ” , improved ” , while at least seven out of ten subjects with a product name of a particulate composition containing serum 2 or 3 answered “ Improved ” or “ Slightly improved ” . anhydrous crystalline ascorbic acid 2 - glucoside commer During the test period of time, there was found no subject cialized by Hayashibara Co ., Ltd ., Okayama, Japan , to with any induced skin problem , revealing that the serums 15 obtain a powdered cosmetic material . have no safety problems. The above results indicate that The product is a composition of a novel particulate serumswith ascorbic acid 2 - glucoside or sodium salt thereof composition containing anhydrous crystalline sodium salt of have an advantageous skin -whitening action and wrinkle ascorbic acid 2 - glucoside and a conventionally frequently improving effect. used particulate composition containing anhydrous crystal The following examples explain the present invention in 20 line ascorbic acid 2 -glucoside , and , similarly as in conven more detail , however, they should never restrict the present tional particulate compositions containing anhydrous crys invention . talline ascorbic acid 2 - glucoside , it can be advantageously used as a cosmetic material , as well as abase material for Example 1 quasi- drugs, pharmaceuticals , foods , etc . Since the product 25 exhibits a weak alkalinity when in an aqueous solution form , < Cosmetic Material > it facilitates the pH adjustment of final products to a desired Five hundred grams of " AA2G ” , a product name of a pH compared to the use of conventional particulate compo particulate composition containing anhydrous crystalline sitions containing anhydrous crystalline ascorbic acid 2 - glu ascorbic acid 2 - glucoside , commercialized by Hayashibara coside . Co ., Ltd ., Okayama, Japan , was dissolved in 500 mL of 8N 30 aqueous sodium hydroxide solution . The solution was Example 4 admixed with 750 mL of ethanol and allowed to stand at 4° C . for five days to precipitate crystals . The resulting mixture < Cosmetic Material> was filtered with a glass filter to collect the crystals , which F ifty parts by mass of a particulate composition contain were then washed with a small amount of 70 % aqueous 35 ing hydrous crystalline sodium salt of ascorbic acid 2 - glu ethanol solution , dried at 40° C . , and pulverized to obtain coside obtained by the method in Example 1 was admixed 326 g of a particulate composition containing hydrous to homogeneity with 50 parts by mass of “ AA2G ” , a crystalline sodium salt of ascorbic acid 2 - glucoside . particulate composition containing anhydrous crystalline The product is a novel particulate composition containing ascorbic acid 2 - glucoside commercialized by Hayashibara the above hydrous crystal and , similarly as in conventional 40 Co. , Ltd ., Okayama, Japan , to obtain a powdered cosmetic particulate compositions containing anhydrous crystalline material. ascorbic acid 2 - glucoside , it can be advantageously used as The product is a composition of a novel particulate a cosmetic material , as well as a base material for quasi- composition containing hydrous crystalline sodium salt of drugs, pharmaceuticals , foods , etc . Since the product exhib - ascorbic acid 2 - glucoside and a conventionally frequently its alkalinity when in an aqueous solution form , it can be 45 used particulate composition containing anhydrous crystal advantageously used in preparing products, where unfavor - line ascorbic acid 2 - glucoside , and , similarly as in conven able inconveniences are inevitably induced depending on a tional particulate composition containing anhydrous crys method of neutralizing ascorbic acid 2 - glucoside with an talline ascorbic acid 2 - glucoside, it can be advantageously alkali . used as a cosmetic material, as well as a base material for 50 quasi -drugs , pharmaceuticals , foods , etc . Since the product Example 2 exhibits a weak acidity when in an aqueous solution form , it facilitates the pH adjustment of final products to a desired < Cosmetic Material > pH compared to the cases with conventional particulate One hundred parts by mass of a particulate composition compositions containing anhydrous crystalline ascorbic acid containing anhydrous crystalline sodium salt of ascorbic 55 2 - glucoside . acid 2 - glucoside obtained by the method in Example 1 was dried in vacuo at 50° C . for 24 hours, and pulverized to Example 5 obtain 81 parts by mass of a particulate composition con taining anhydrous crystalline ascorbic acid 2 - glucoside . < Cosmetic Lotion > The product is a novel particulate composition containing 60 ( Formulation ) anhydrous crystalline ascorbic acid 2 - glucoside and , simi larly as in conventional particulate compositions containing anhydrous crystalline ascorbic acid 2 - glucoside , it can be Ingredient % by mass ) advantageously used as a cosmetic material, as well as abase ( 1 ) Glycerin 4 . 0 material for quasi- drugs , pharmaceuticals , foods, etc . Since 65 ( 2 ) Propylene glycol 3 . 0 the product exhibits alkalinity when in an aqueous solution ( 3 ) 1 , 2 - Pentane diol 0 . 1 form , it can be advantageously used in preparing products , US 10 , 111 ,822 B2 85 86 -continued Example 7 Ingredient (% by mass) < Milky Lotion > ( 4 ) Cosmetic material obtained by (Formulation ) the method in Example 3 5 ( 5 ) Polyoxyethylene ( 20 moles) olein alcohol Ingredient ( 6 ) Saxifraga stolonifera ( % by mass ) (beefsteak geranium ) extract ( 1 ) 1 , 2 - Hexane diol 5 .0 ( 7 ) Ethanol ( 2 ) Octyldodecanol 4 . 0 ( 8 ) Flavor q . s . 10 ( 3 ) Kojic acid 1 . 0 ( 9 ) Refined water Remaining ( 4 ) Cosmetic material obtained by 1 . 0 the method in Example 3 (5 ) Polyoxyethyleneoleylether ( 20E . O . ) 1 . 0 The ingredients ( 1 ) to ( 4 ) in the above formulation were (6 ) Stearic acid ? dissolved in refined water ( 9 ) and then gradually admixed ( 7 ) Shea butter = ( 8 ) Beeswax Onto2 with a mixture of the ingredients (5 ) to ( 8 ) to obtain a 15 ( 9 ) Para - hydroxybenzonate 0 . 2 cosmetic lotion . The product is an improved cosmetic lotion ( 10 ) Cydonia oblonga seed extract 5 . 0 that exerts a stable anti -wrinkle action and is useful as an ( 11 ) Xanthan gum 0 . 1 anti - ageing cosmetic lotion that has an improved anti ( 12 ) Phytic acid 0 .02 wrinkle or anti - fine -wrinkle action , as well as having a ( 13 ) Vitamin E 0 . 01 skin -whitening , anti -blemish , or anti -sagging skin action , 20 ( 14 ) Refined water Remaining and maintaining or promoting the barrier function and the hyaluronic acid production in the skin . Since the product The above ingredients (1 ), ( 3 ), ( 10 ), and ( 11 ) and refined contains 1 , 2 -pentane diol, it has a satisfactory antiseptic water ( 14 ) were mixed to obtain a water phase . The ingre effect and a moisture -retaining ability , as well as having a dients ( 2 ) , ( 5 ) to ( 9 ) , ( 12 ) , and ( 13 ) were heated and mixed lesser skin stimulation and being inhibited from precipitat- 25 to obtain an oil phase . The water phase was added to the oil ing effective ingredients such as ascorbic acid 2 - glucoside . phase , mixed to homogeneity , cooled , and admixed to homo geneity with the ingredient (4 ) to obtain a milky lotion . The Example 6 product is an improved milky lotion that exerts a stable anti -wrinkle action and is advantageously used as an anti < Cosmetic Lotion > 30 ageing milky lotion having an improved anti -wrinkle , anti (Formulation ) fine -wrinkle , skin -whitening , anti -blemish , and anti - sag ging - skin actions, as well as having an improved action of maintaining or promoting the barrier function and the Ingredient % by mass ) of hyaluronic acid production in the skin . ( 1 ) Glycery monostearate 0 . 5 ( 2 ) Olea europaea (olive ] oil 0 . 5 Example 8 ( 3 ) Glycerin 6 .0 (4 ) 1, 3 - Butylene glycol 10 . 0 ( 5 ) Ethanol 5 . 0
Ingredient ( % by mass ) 45 Ingredient % by mass ) ( 1 ) Potassium laurate 2. 0 ( 1 ) Lauric acid 5 . 0 ( 2 ) Potassium myristate 17 . 0 ( 2 ) Oleic acid 5 . 0 ( 3 ) Palmitic acid ( 3 ) Sodium methyl cocoyl taurate 18 . 0 ( 4 ) Stearic acid 4. 0 ( 4 ) Sodium cocoamphoacetate 20 . 0 ( 5 ) Palm kernel oil fatty acid 3 . 0 50 (5 ) Hyaluronic acid 2 .0 diethanolamide ( 6 ) “ TORNARE ” , a product name of a syrup 1 . 0 ( 6 ) Glycerin 10 . 0 containing saccharide derivatives (7 ) 1, 3 -Butylene glycol 10 . 0 of trehalose , commercialized by ( 8 ) “ TORNARE ” , a product name of a syrup 5 . 0 Hayashibara Co ., Ltd . , Okayama, Japan containing saccharide derivatives of ( 7 ) Cosmetic material obtained 2 . 0 trehalose , commercialized by Hayashibara 55 by the method in Example 2 Co. , Ltd ., Okayama, Japan ( 8 ) Sodium chloride 0 .2 ( 9 ) Cosmetic material obtained 3 . 0 ( 9 ) Etidronic acid 0 . 1 by the method in Example 2 ( 10 ) Disodium ethylenediaminetetraacetic 0 . 1 (10 ) Sodium ethylenediaminetetraacetic acid 0 . 2 acid (11 ) Sodium methyl cocoyl taurate 10 . 0 ( 11) Potassium hydroxide q . s . ( 12 ) Refined water Remaining Remaining - 60 ( 12 ) Refined water According to the above formulation , a cleansing foam According to the above formulation , a body soap was was prepared in usual manner. The product is useful as a prepared in usual manner. The product is useful as a body cleansing foam for anti - ageing because it exerts a stable soap for anti -ageing because it exerts a stable anti -wrinkle or anti - wrinkle or anti - fine- wrinkle action , has an improved 65 anti - fine- wrinkle action , has an improved action of main action of maintaining or promoting the barrier function and taining or promoting the barrier function and the hyaluronic the hyaluronic acid production in the skin , and has an acid production in the skin , and has a skin -whitening and US 10 , 111 , 822 B2 91 92 anti -blemish actions, and because you can enjoy its rich The product is useful as an anti -ageing sunscreen ( O / W texture feeling after washing your face therewith . emulsion type ) that exerts a stable skin -whitening action ; has an improved anti -wrinkle action , anti- fine -wrinkle Example 17 action , and improved action of maintaining or promoting the barrier function and the hyaluronic acid production in the < Cleansing Cream > skin ; and has a uniform spreadability over the skin , lesser (Formulation ) stickiness , improved moisture - retaining ability of smoothing the skin texture, etc . , and improved temporal stability . Ingredient ( % by mass ) 10 Example 19 ( 1 ) Liquid paraffin 35 . 0 ( 2 ) Petrolatum 17. 0 < Skin Whitening Milky Lotion ( O / W Emulsion Type ) > ( 3 ) Cetyl alcohol (4 ) Stearic acid (Formulation ) (5 ) Glycerin 3. 0 15 ( 6 ) Propylene glycol 2 .0 ( 7 ) Polyoxyethylene isocetyl ether ( 10E . O .) ?? Ingredient ( % by mass ) ( 8 ) Glycery monostearate ( 9 ) 1, 2 - Pentanediol ?? ( 1 ) Decaglyceryl pentastearate 0 . 5 ( 10 ) Cosmetic material obtained 1 . 0 ( 2 ) Polyoxyethylene (10 moles ) 0 .2 cholesteryl ether by the method in Example 3 20 ( 11 ) Flavor q . s . ( 3 ) Jojoba oil 3 . 0 ( 12 ) Refined water Remaining ( 4 ) “ LECINOL S - 10 " , a hydrogenated 2 . 5 soybean phospholipid commercialized by Nikko Chemicals Co . , Ltd ., Tokyo , According to the above formulation, a cleansing cream Japan ( 5 ) Glycerin 5 . 0 was prepared in usual manner. The product is directed for ( 6 ) Dipropylene glycol 10 . 0 use in washing the skin and removing make -ups , and you ( 7 ) Arbutin 7 .0 can enjoy its rich texture feeling after washing your skin and ( 8 ) Cosmetic material obtained 1 . 0 by the method in Example 3 face therewith . The product is useful as a cleansing cream ( 9 ) Disodium ethylenediaminetetraacetate 0 . 1 for anti -ageing that exerts a stable anti -wrinkle or anti - fine ( 10 ) Succinic acid 0 . 1 wrinkle action , has an improved action of maintaining or 30 ( 11 ) Ethanol 5 . 0 promoting the barrier function and the hyaluronic acid ( 12 ) Sodium hydroxide q . s . production in the skin , and has an improved skin -whitening (13 ) Refined water Remaining and anti- blemish actions. (Production Method ) Example 18 35 A . The ingredients ( 1 ) to ( 4 ) were heated to 75º C . and dissolved by mixing to homogeneity . < Sunscreen for Skin -Whitening ( O / W Emulsion Type ) > B . The ingredients ( 5 ) to ( 10 ), ( 12) , and ( 13 ) were heated to ( Formulation ) 75° C . and dissolved by mixing to homogeneity . 40 C . The above B was added to A and the mixture was Ingredient emulsified . % by mass ) D . The above C was cooled and added with the ingredient ( 1 ) Decaglyceryl pentaoleate 1 . 5 ( 11 ) to obtain a skin -whitening milky lotion ( O / W emulsion ( 2 ) Polyoxyethylene ( 10 moles ) 1 . 0 cholesteryl ether type ). ( 3 ) Hydrogenated soybean phospholipid 1 . 5 45 The product is useful as a skin - whitening milky lotion for ( 4 ) Glycerin 5 . 0 anti- ageing ( O / W emulsion type ) that exerts a stable anti ( 5 ) 2 -Ethylhexyl p -methoxycinnamate 5 . 0 (6 ) Dipropylene glycol 10 . 0 wrinkle or anti - fine - wrinkle action and has an improved ( 7 ) Arbutin 3 . 0 action of maintaining or promoting the barrier function and ( 8 ) Pentasodium 0 . 1 the hyaluronic acid production in the skin , improved skin diethylenetriaminepentaacetate 50 whitening or anti- blemish action , uniform spreadability over ( 9 ) Cosmetic material obtained 1 . 0 the skin , lesser stickiness , improved moisture - retaining abil by the method in Example 3 ( 10 ) Malic acid 0 . 2 ity of smoothing the skin texture , etc . , and improved tem (11 ) Ethanol 2. 0 poral stability . ( 12 ) Flavor q . s . ( 13 ) Methyl 4 -hydroxybenzoate q. s . ( 14 ) Sodium hydroxide q .s . 55 Example 20 ( 15 ) Refined water Remaining < Cosmetic Base Material for Improving Skin Turnover> (Production Method ) (Formulation ) A . The ingredients ( 1 ) to ( 3 ) and ( 5 ) were heated to 75º C . 60 and dissolved by mixing to homogeneity . B . The ingredients ( 4 ), (6 ) to (10 ), ( 14 ), and (15 ) were heated Ingredient ( % by mass ) ( 1 ) “ AA2G ” , a product name of a 25 . 0 to 75º C . and dissolved by mixing to homogeneity . particulate composition containing C . The above B was added to A and the resulting mixture anhydrous crystalline ascorbic acid was emulsified . 65 2 - glucoside , commercialized by D . The above C was cooled and added with the ingredients Hayashibara Co ., Ltd ., Okayama, Japan (11 ) to ( 13 ) to obtain a sunscreen ( skin - whitening type ) . US 10 , 111, 822 B2 93 94 -continued and impart an action of maintaining or promoting the barrier function and the hyaluronic acid production in the skin , as Ingredient ( % by mass) well as imparting a skin - whitening, anti - blemish , and anti ( 2 ) " aG Rutin ” , a product name of sagging skin actions . Since the products contain both the a - glucosyl rutin commercialized 5 Eucommia ulmoides leaf extract with a skin - turnover -im by Toyo Sugar Refining Co ., Ltd . , Tokyo , Japan proving action and a glycation - inhibitory action and the ( 3 ) Polyoxyethylene alkyl ether 0 . 9 Ganoderma lucidum extract or Phallus impudicus extract , it ( 4 ) Olea europaea ( olive ] leaf extract 0 .01 imparts an instant skin - turnover- improving effect and effec with skin - turnover - improving action tively exerts a skin ageing inhibitory effect , along with the ( 5 ) Potassium hydroxide q . s . ( 6 ) Sodium citrate q . s . action by the ingredient (1 ). Since the Eucommia ulmoides ( 7 ) Refined water Remaining leaf extract with a skin -turnover - improving action , which is used in combination with ascorbic acid 2 - glucoside , effec The above ingredients ( 1 ) to (7 ) were stirred at ambient tively inhibits the formation of advanced glycation end temperature and mixed for dissolving, and the resulting 15 products ( AGES ) , unfavorable deposition of AGEs in skin mixture was filtered to obtain a base material for skin tissues is lowered or inhibited , resulting in forming disor turnover - improving cosmetic (pH 6 .0 ), followed by being dered cross - linkages in collagen intra - and inter -molecularly injected into a light- shielded container . By being incorpo during the generation of AGEs to lower or inhibit the rated into cosmetics , the product imparts a skin -turnover induction of physical and physiological changes (denatur improving action and stable anti- wrinkle or anti - fine - 20 ations ) in collagen , whereby the external signs of skin wrinkle action , as well as actions of maintaining or ageing such as wrinkles, rough skin , dullness , and reduction promoting the barrier function and the hyaluronic acid of firmness are effectively prevented or improved . The production in the skin , and of imparting skin -whitening products can be preferably incorporated into cosmetics as anti- blemish , and anti - sagging to the skin . Since, along with rapidly effective fine -wrinkle - improving agents for women the action of the above ingredient ( 1 ) , the product contains 25 in midlife , let alone so - called pre -aging generation . Further, both the olive leaf extract and the a -glucosyl rutin capable women , who are being pressed by daily works and liable to of improving the skin turnover , it is distinctly useful in that be negligent of their skin care , can be rapidly improved in it also effectively imparts an instant skin -turnover - improv their skin -turnover by applying an appropriate amount of a ing action , skin - protecting action from ultraviolet ray, and cosmetic incorporated with any one of the products to their antioxidant action . The product can be preferably incorpo - 30 skin at bedtime to effectively penetrate the effective ingre rated into cosmetics as a rapidly effective fine -wrinkle dients into their skin during sleeping . improving agent for women in midlife , let alone so - called pre - aging generation . Further, women , who are being Example 22 pressed by daily works and liable to be negligent of their skin care , can be rapidly improved in their skin turnover by| 35 < Cosmetic Base Material for Improving Skin Turnover> applying an appropriate amount of a cosmetic incorporated (Formulation ) with the product to their skin at bedtime to effectively penetrate the effective ingredients into their skin during sleeping Ingredient % by mass ) 40 ( 1 ) “ AA2G ” , a product name of a 25 . 0 Example 21 particulate composition containing anhydrous crystalline ascorbic acid 2 - glucoside, commercialized by < Cosmetic Base Material for Improving Skin Turnover > Hayashibara Co ., Ltd ., Okayama, Japan (Formulation ) ( 2 ) Polyoxyethylene alkyl ether 0 . 9 45 ( 3 ) Any one of the following extracts 0 . 01 having a skin - turnover- improving action selected from Olea europaea lient % by mass ) extract , Glycyrrhiza uralensis ( 1 ) “ AA2G ” , a product name of a 25 . 0 extract , Triticum vulgare germ extract , particulate composition containing Salvia officinalis extract, anhydrous crystalline ascorbic acid 50 Mentha extract, Camellia japonica extract, 2 - glucoside , commercialized by Polygonum tinctorium Lour. leaf extract , Hayashibara Co . , Ltd . , Okayama, Japan Aloe barbadensis extract , Olea europaea (2 ) Ganoderma lucidum extract or 0 .01 extract , Matricaria recutita extract, Phallus impudicus extract Saxifraga stolonifera extract, Citrus junos ( 3 ) Eucommia ulmoides leaf extract 0 .02 extract , Citrus limon extract , with skin - turnover- improving action 55 Rosmarinus officinalis L . extract , and Chlorellaceae extract , royal jelly extract , glycation - inhibitory action and Gardenia jasminoides extract . ( 4 ) Glycerin - fatty acid ester 0 . 8 ( 4 ) Potassium hydroxide q . s . ( 5 ) Sodium hyaluronate 1. 0 ( 5 ) Sodium citrate q . s . (6 ) Potassium hydroxide q . s . (6 ) Refined water Remaining ( 7 ) Refined water Remaining 60 Any one of the above ingredients ( 1 ), ( 2 ), and ( 3 ) and the The above ingredients ( 1 ) to ( 7 ) were stirred at ambient above ingredients ( 4 ) to (6 ) were stirred at ambient tem temperature, dissolved by mixing , adjusted to pH 6 . 0 , and perature , mixed for dissolving, and filtered to obtain 17 filtered to obtain two types of base materials for skin types base materials (pH 6 . 0 ) for improving skin turnover, turnover - improving cosmetics. By being incorporated into 65 followed by being injected into light- shielded containers . By cosmetics , the products impart a skin - turnover - improving being incorporated into cosmetics, the products impart a action and a stable anti -wrinkle or anti - fine -wrinkle action , skin - turnover- improving and stable anti -wrinkle actions or US 10 , 111 , 822 B2 95 96 an anti- fine - wrinkle action , as well as actions ofmaintaining and 1 , 2 -octanediol having an antiseptic action and the Kan or promoting the barrier function and the hyaluronic acid kohso 201, having an improved compatibility with the above production in the skin , and of skin -whitening , anti -blemish , diols , at a relatively high concentration , they exert a superior and anti - sagging to the skin . Since , along with the action of antiseptic effect by being incorporated into cosmetics in an the above ingredient (1 ), the products contain both the plant 5 adequate amount. Since the products contain pullulan along extract having a skin - turnover- improving action , it is dis with the ingredient ( 1 ), they are useful as cosmetic base tinctly useful in that they also effectively impart an instant materials capable of effectively imparting a moisturizing skin - turnover -improving action , skin -protecting action from effect to the skin . In addition , cosmetics with anyone of the ultraviolet ray, and antioxidant action . The products can be products rapidly improve the skin turnovers of women who preferably incorporated into cosmetics as a rapidly effective " are being pressed by daily works and liable to be negligent fine -wrinkle - improving agents for women in midlife , let of their skin care , when applied to their skin in an appro alone so -called pre -aging generation . Further, women , who priate amount at bedtime to effectively penetrate the effec are being pressed by daily works and liable to be negligent tive ingredients into their skin during sleeping and to rapidly of their skin care , can be rapidly improved in their skin turnovers by applying an appropriate amount of a cosmetic 155 improve their skin turnovers . incorporated with any one of the products to their skin at bedtime to effectively penetrate the effective ingredients into Example 24 their skin during sleeping . < Cosmetic Base Material for Improving Skin Turnover > Example 23 (Formulation ) < Base Material for Antiseptic Cosmetics > ( Formulation ) Ingredient ( % by mass) 25 Ingredient ( % by mass ) ( 1 ) “ AA2G ” , a product name of a 25 . 0 particulate composition containing ( 1 ) “ AA2G ” , a product name of a 25 . 0 particulate composition containing anhydrous crystalline ascorbic acid anhydrous crystalline ascorbic acid 2- glucoside, commercialized by 2 - glucoside , commercialized by 30 Hayashibara Co ., Ltd ., Okayama , Japan Hayashibara Co ., Ltd . , Okayama, Japan ( 2 ) “ Kankohso 201” (PIONIN ) , 0 .01 (2 ) Hyaluronic acid 1 . 0 commercialized by Hayashibara Co ., ( 3 ) Fragaria vesca extract having 0 .01 Ltd . , Okayama, Japan a skin - turnover - improving action 0 .01 ( 3 ) Any one of 1 , 2 -Pentanediol , 2 . 0 1 , 2 -hexanediol , 1 , 2 -heptanediol , and 35 ( 4 ) Equol having a skin- turnover 1 , 2 - octanediol improving action and glycation ( 4 ) Hyaluronic acid 1 . 0 inhibitory action ( 5 ) Paeonia lactiflora extract having 1 . 0 a glycation - inhibitory action ( 5 ) Polyoxyethylene hydrogenated 1 . 0 ( 6 ) Glycerin fatty acid ester 0 . 8 castor oil (7 ) “ COSMETIC PULLULAN ” , a product name 0 . 4 40 ( 6 ) Potassium hydroxide q .s . of pullulan , commercialized by Hayashibara ( 7 ) Sodium citrate q . s . Co ., Ltd ., Okayama, Japan ( 8 ) Refined water Remaining ( 8 ) Potassium hydroxide q . s . ( 9 ) Refined water Remaining 45 The above ingredients (1 ) to ( 8 ) were stirred while Either of the above ingredients ( 1) and (4 ) to (9 ), or the heating , mixed for dissolving , and filtered to obtain a base ingredient ( 2 ) and any one of the ingredient ( 3 ) were material ( pH 6 . 0 ) for skin -turnover - improving cosmetics , respectively stirred at ambient temperature and mixed for followed by being injected into a light- shielded container . In dissolving . The resulting solutions were mixed , adjusted to particular, the product, which contains , along with the pH 6 . 0 , filtered into four types of base materials for anti - 50 ingredient ( 1) , the Fragaria vesca extract having a skin septic cosmetics, and injected into light shielded containers . turnover - improving action and the equol having a skin In particular, these products , which contain the Paeonia turnover -improving action and a glycation - inhibitory action , lactiflora extract having a glycation - inhibitory action , impart a distinct skin - turnover - improving effect, and effec effectively improves the skin turnover rapidly , exerts a stable tively exert a skin anti- ageing inhibitory effect , along with 55 anti - wrinkle action , anti - fine- wrinkle action , action ofmain the action of the ingredient ( 1) . By being incorporated into taining or promoting the barrier function and the hyaluronic cosmetics in a desired amount, the products can be made acid production in the skin , skin -whitening action , anti into liquid cosmetic base materials capable of imparting to blemish action , and anti - sagging action . The product can be such cosmetics a stable anti -wrinkle action , anti - fine suitably incorporated into cosmetics as a rapidly effective wrinkle action action of maintaining or promoting the 60 fine -wrinkle - improving agent for women in midlife includ barrier function and the hyaluronic acid production in the ing so called pre -ageing generation . In addition , cosmetics skin , skin -whitening action , anti -blemish action , and anti with the product rapidly improve the skin turnovers of sagging action . Particularly , the products can be suitably women who are being pressed by daily works and liable to incorporated into cosmetics as rapidly effective fine - be negligent of their skin care , when applied to their skin in wrinkle - improving agents for so called pre -aging generation 65 an appropriate amount at bedtime to effectively penetrate the including women in midlife . Since the products contain any effective ingredients into their skin during sleeping and to one of the 1 , 2 -pentanediol , 1 , 2 -hexanediol , 1 , 2 -heptanediol , rapidly improve their skin turnovers . US 10 , 111, 822 B2 97 98 Example 25 material with Ganoderma lucidum extract was selected from the two types of cosmetic base materials , the cosmetic base < Cosmetic Base Material for Improving Skin Turnover> material for improving skin turnover obtained in Example (Formulation ) 24 , and the particulate composition containing anhydrous 5 crystalline ascorbic acid 2 - glucoside . < Test Cream > Ingredient ( % by mass ) (Formulation ) ( 1 ) “ AA2G ” , a product name of a 25 . 0 particulate composition containing anhydrous crystalline ascorbic acid 10 Ingredient ( % by mass ) 2 - glucoside, commercialized by Hayashibara Co ., Ltd ., Okayama, Japan ( 1 ) Dimethicone 0 . 3 ( 2 ) Hyaluronic acid 1 .0 ( 2 ) Squalane 2 . 0 ( 3 ) One percent by mass of any one of ( 3 ) Cetearyl isononanoate 1 . 0 extracts of Withania somnifera , ( 4 ) Triethylhexanoin Thujopsis dolabrata , Acacia catechu , 15 (5 ) Octyldodecanol Ginkgo biloba , Gaultheria procumbens, ( 6 ) C10 - 30 Cholesterol/ lanosterol esters = Phellodendron amurense , Citrus sinensis , ( 7 ) Polyglyceryl - 10 myristate ??? seed of Cucurbita , bark of Erythroxylum ( 8 ) Cetyl alcohol catuaba , Mallotus philippinensis , ( 9 ) Batyl alcohol ? Fagopyrum esculentum , Davilla rugosa , (10 ) Cetyl palmitate ?
Houttuynia cordata , Elatostema japonicum ( 11 ) Glyceryl stearate SE ? var . japonicum , Crassocephalum crepidioides , 20 (12 ) Batyl stearate Actinidia polygama, Pleioblastus linearis , ( 13 ) 1 , 3 - Butylene glycol ? Rubus croceacanthus, unripe fruit of Malus (14 ) Methylparaben ? pumila , leaves of Diospyros kaki Thunberg , ( 15 ) Glycerin nirimmimitririnimo+? leaves of Glycyrrhiza uralensis , leaves of ( 16 ) “ TORNARE ” , a product name of a syrup 2 . 0 Alpinia zerumebet, protein hydrolyzates of containing saccharide derivatives of pearls , equol, isoflavone , ifenprodil , 25 trehalose , commercialized by catechol , caffeine acid , and prunin , which Hayashibara Co ., Ltd . , Okayama, Japan have a skin - turnover - improving action and /or (17 ) 20 .0 % by mass of any one of cosmetic base a glycation - inhibitory action materials for improving skin turnover ( 4 ) Glycerin fatty acid ester 0 . 8 obtained in Examples 20 , 21 and 24 ; or 5 . 0 % by ( 5 ) Potassium hydroxide q .s . mass of “ AA2G ” , a product name of a particulate ( 6 ) Refined water Remaining 30 composition containing anhydrous crystalline 2 - glucoside commercialized by Hayashibara Co . , Ltd. , Okayama, Japan The above ingredients ( 4 ) to (6 ) and any one of the above ( 18 ) Malic acid 0 .02 ( 19 ) Sodium malate 0 . 3 ingredients (1 ) to (3 ) were mixed by stirring at ambient ( 20 ) Potassium hydroxide 0 . 3 temperature, adjusted to pH 6 .0 , and filtered to obtain 32 35 ( 21 ) Lanolin 0 . 1 types of base materials for skin -turnover - improving cosmet (22 ) Refined water q . s . ics , followed by being injected into light- shielded contain ers. In particular, these products , which contain , along with Since all the above four types of skin - turnover -improving the action of the above ingredient ( 1 ), any of the above plant a gents exert outstanding fine -wrinkle - improving effects and extracts having a skin - turnover- improving action and / or a 40 have improving actions on fine -wrinkles accompanied by glycation - inhibitory action and other ingredients , effectively ageing , they are distinctly useful as rapidly effective anti impart a distinct skin - turnover - improving effect and exert a wrinkle - improving agents for women in midlife including so skin - ageing - inhibitory effect. When incorporated into vari- called pre - aging generation . The skin - turnover - improving ous cosmetics in desired amounts, these products in the form agents , prepared with the cosmetic base material for improv of a cosmetic base material, impart a stable anti -wrinkle 45 ing skin turnover obtained in Example 21 or 24 , contain action , anti - fine - wrinkle action , action of maintaining or ascorbic acid 2 - glucoside and other ingredient with a skin promoting the barrier function and the hyaluronic acid turnover - improving action and a glycation - inhibitory action ; production in the skin , skin -whitening action , anti -blemish the agents exert a more improved skin -turnover - rate - im action , and anti -sagging action . Particularly , they can be proving action than those prepared with the cosmetic base suitably incorporated into various types of cosmetics as 50 material for improving skin turnover in Example 20 , which rapid , effective fine -wrinkle - improving agents for women in had been incorporated with only the ingredient having a midlife including so called pre -ageing generation . In addi skin - turnover - improving action along with ascorbic acid tion , cosmetics with any of these products rapidly improve 2 - glucoside. The skin - turnover - improving agent, prepared the skin turnovers of women who are being pressed by daily with the cosmetic base material for improving skin turnover works and liable to be negligent of their skin cares , when 55 in Example 20 , exerts a more improved skin - turnover- rate applied to their skin in an appropriate amount at bedtime to improving action than that prepared with a particulate com effectively penetrate the effective ingredients into their skin position containing anhydrous crystalline ascorbic acid during sleeping and to rapidly improve their skin turnovers . 2 - glucoside as the above ingredient (17 ) ; and also exerts an action of maintaining or promoting the skin barrier function Example 26 60 and the hyaluronic acid production in the skin , as well as a skin -whitening action , anti -blemish action , and anti - sagging < Skin - Turnover- Improving Agent> action . According to the following formulation , four types of the present skin -turnover - improving agents were prepared by INDUSTRIAL APPLICABILITY using , as the following ingredient ( 17 ) , any one of the 65 cosmetic base materials for improving skin turnover The external dermal composition and the basic skin cares obtained in Examples 20 , 21, where the cosmetic base such as cosmetic lotions, face washes, serums, milky lotions, US 10 , 111 ,822 B2 99 100 and creams, all of which contain the composition , according 3 . The composition of claim 1 , wherein said sodium salt to the present invention , have an improved anti -wrinkle , of 2 - 0 - a - D - glucosyl- L -ascorbic acid in a crystalline form is anti- fine -wrinkle , anti -blemish , and anti- sagging skin a hydrous crystalline sodium salt of 2 - 0 - a - D - glucosyl- L effects , and thus they are outstandingly useful as a means for realizing a common and universal desire of humans who 5 ascorbic acid having diffraction angles ( 20 ) of 6 .8° , 8 . 2° , wish to be young to the end of time. 10 5 14. 3°, 17 .8° , and 18 .4° ; or an anhydrous crystalline sodium Also , the external dermal composition and the basic skin salt of 2 - 0 - C - D - glucosyl- L -ascorbic acid having diffraction cares such as cosmetic lotions, face washes, serums, milky angles ( 20 ) of 8 . 0° , 9 .0° , 16 . 4° , 17 . 9°, and 20 . 8° , when lotions, and creams, all of which contain the composition , determined on powder X - ray diffraction analysis . according to the present invention , are easily produced by a 10 4 . A crystal of sodium salt of 2 - 0 - a - D - glucosyl -L - ascor production method containing a step of mixing the desired 10 bic acid . effective ingredient( s ) with an aqueous medium ; the use of 5 . The crystal of claim 4 , which is in a hydrous crystalline a crystalline form of ascorbic acid 2 -glucoside or of a form having diffraction peaks at diffraction angles (20 ) of sodium salt thereof as a particularly suitable effective ingre 6 .8° , 8 .2° , 14 .3° , 17 .8° , and 18 .4° , or in an anhydrous dient will provide a distinctly advantageous benefit of crystalline form having diffraction peaks at diffraction expecting constantly fixed or unchangeable known and 15 angles ( 20 ) of 8 . 0°, 9 . 0°, 16 . 4°, 17 . 9°, and 20 . 8º. stable properties, let alone an advantage of affording the use 6 . The crystal of claim 5 , wherein said hydrous crystal of high -purity raw materials with lesser impurities . belongs to an orthorhombic system and exhibits a space Further, in the case of using crystalline sodium salt of group of Pbca (# 61) and a lattice constant of a = 6 . 9733 Å , ascorbic acid 2 - glucoside and anhydrous crystalline ascorbic 20 b = 14 .4839 Å , c = 19 .3221 Å , and V = 1951. 54 Å3 . acid 2 - glucoside in combination , an appropriate control of 20 7 . A method for producing said crystal of sodium salt of the ratio of the above ingredients enables the pH adjustment 2 - 0 - C - D - glucosyl- L -ascorbic acid of claim 4 , which com of final products to a pH within a prescribed pH range , prises the steps of: without neutralizing ascorbic acid 2 - glucoside with an ( a ) dissolving 2 - 0 - a - D - glucosyl- L - ascorbic acid in an alkali ; whereby the external dermal composition for anti - 35 aqueous sodium hydroxide solution ; ageing and the basic skin cares such as cosmetic lotions, face (b ) adding an organic solvent to the resulting solution ; washes, serums, milky lotions , and creams, all of which ( c ) allowing the resulting mixture to stand to precipitate a contain the composition , according to the present invention , crystal of sodium salt of 2 -0 - C - D - glucosyl- L -ascorbic can be readily produced with a lesser production step ( s ) . The acid ; and present invention with such outstanding various advantages 30 (d ) collecting the precipitated crystal. has a distinctly significant industrial usefulness. 30 8 . A composition comprising the crystal of sodium salt of The invention claimed is : 2 - 0 - C - D - glucosyl- L -ascorbic acid of claim 4 . 1 . A composition which comprises 2 - 0 - a - D - glucosyl - L 9 . The composition of claim 8 , which further comprises ascorbic acid and sodium salt thereof that are in a crystalline L -ascorbic acid or its derivative including a glycosyl- , acyl- , form . or phosphoryl- derivative of L - ascorbic acid . 2 . The composition of claim 1 , wherein the ratio of saidid 35 10 . The composition of claim 9 , wherein said glycosyl 2 - 0 - a - D - glucosyl- L - ascorbic acid and said sodium salt derivative of L -ascorbic acid is 2 - 0 - a - D - glucosyl- L - ascor thereof is in the range of 60 :40 to 45 : 55 by mass, on a dry bic acid . solid basis. * * * * *