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Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity
toxins Article Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity Massimo Picardo 1 , Oscar Núñez 2,3 and Marinella Farré 1,* 1 Department of Environmental Chemistry, IDAEA-CSIC, 08034 Barcelona, Spain; [email protected] 2 Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, 08034 Barcelona, Spain; [email protected] 3 Serra Húnter Professor, Generalitat de Catalunya, 08034 Barcelona, Spain * Correspondence: [email protected] Received: 5 October 2020; Accepted: 26 November 2020; Published: 28 November 2020 Abstract: This study presents the application of a suspect screening approach to screen a wide range of natural toxins, including mycotoxins, bacterial toxins, and plant toxins, in surface waters. The method is based on a generic solid-phase extraction procedure, using three sorbent phases in two cartridges that are connected in series, hence covering a wide range of polarities, followed by liquid chromatography coupled to high-resolution mass spectrometry. The acquisition was performed in the full-scan and data-dependent modes while working under positive and negative ionisation conditions. This method was applied in order to assess the natural toxins in the Ter River water reservoirs, which are used to produce drinking water for Barcelona city (Spain). The study was carried out during a period of seven months, covering the expected prior, during, and post-peak blooming periods of the natural toxins. Fifty-three (53) compounds were tentatively identified, and nine of these were confirmed and quantified. Phytotoxins were identified as the most frequent group of natural toxins in the water, particularly the alkaloids group. -
H4R Position on Rosin As One Substance For
H4R Position Statement on Rosin, Rosin Salts and Rosin Esters Registered as One Substance 7th February 2019 REACH registrations of Rosin, Rosin Salts and Rosin Esters H4R Position Statement on One Substance Registration Historically, various names, CAS, and EINECS numbers have existed for rosin. REACH1 mandates “One Substance – One Registration”. This obliged the Rosin registrants to carefully examine the composition of their substances of interest. They concluded that, although Rosin is historically listed under different names and EINECS and CASRNs (e.g. Rosin; Tall-oil rosin; Resin acids and rosin acids; etc.), it needed to be considered as one and the same substance. In addition, the registrants concluded that rosin is a chemical substance of Unknown or Variable Composition, Complex Reaction Products and Biological Materials (UVCB). In other words, rosin was listed on EINECS and CAS under different names, but the rosin registrants determined that differentiation was not justified and appropriate as these are the same UVCB substances. Therefore, Rosin with CAS 8050-09-7 was chosen. Appendix 1 to this document outlines the registrations that cover each of these substances. This decision and its rationale for one rosin registration is well documented in two papers: “Justification for grouping rosin and rosin derivatives into families” by Gary McCallister (Hercules), Bert Lenselink (Hexion), Jerrold Miller (Arizona Chemical), Bill Grady (Arizona Chemical) and Leon Rodenburg (Eastman Chemical), 24 August 20102 “Justification for considering Rosin as a Single Substance” by H4R Consortium, 22 February 20103 Based on these papers, it was concluded that, for rosin and the derived rosin salts, fortified rosin, fortified rosin salts, rosin esters and fortified rosin esters, the starting rosin is not relevant. -
162 Part 175—Indirect Food Addi
§ 174.6 21 CFR Ch. I (4–1–19 Edition) (c) The existence in this subchapter B Subpart B—Substances for Use Only as of a regulation prescribing safe condi- Components of Adhesives tions for the use of a substance as an Sec. article or component of articles that 175.105 Adhesives. contact food shall not be construed as 175.125 Pressure-sensitive adhesives. implying that such substance may be safely used as a direct additive in food. Subpart C—Substances for Use as (d) Substances that under conditions Components of Coatings of good manufacturing practice may be 175.210 Acrylate ester copolymer coating. safely used as components of articles 175.230 Hot-melt strippable food coatings. that contact food include the fol- 175.250 Paraffin (synthetic). lowing, subject to any prescribed limi- 175.260 Partial phosphoric acid esters of pol- yester resins. tations: 175.270 Poly(vinyl fluoride) resins. (1) Substances generally recognized 175.300 Resinous and polymeric coatings. as safe in or on food. 175.320 Resinous and polymeric coatings for (2) Substances generally recognized polyolefin films. as safe for their intended use in food 175.350 Vinyl acetate/crotonic acid copoly- mer. packaging. 175.360 Vinylidene chloride copolymer coat- (3) Substances used in accordance ings for nylon film. with a prior sanction or approval. 175.365 Vinylidene chloride copolymer coat- (4) Substances permitted for use by ings for polycarbonate film. 175.380 Xylene-formaldehyde resins con- regulations in this part and parts 175, densed with 4,4′-isopropylidenediphenol- 176, 177, 178 and § 179.45 of this chapter. -
8341 No Clean Flux Paste
8341 No Clean Flux Paste MG Chemicals UK Limited Version No: A-1.0 2 Issue Date:26/04/2018 Safety Data Sheet (Conforms to Regulation (EU) No 2015/830) Revision Date: 14/01/2021 L.REACH.GBR.EN SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING 1.1. Product Identifier Product name 8341 Synonyms SDS Code: 8341; 8341-10ML; 8341-10MLCA, 8341B-10ML | UFI: HGH0-205D-2003-EPAT Other means of identification No Clean Flux Paste 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses For use with leaded and unleaded solder during soldering process Uses advised against Not Applicable 1.3. Details of the supplier of the safety data sheet Registered company name MG Chemicals UK Limited MG Chemicals (Head office) Heame House, 23 Bilston Street, Sedgely Dudley DY3 1JA United Address 9347 - 193 Street Surrey V4N 4E7 British Columbia Canada Kingdom Telephone +(44) 1663 362888 +(1) 800-201-8822 Fax Not Available +(1) 800-708-9888 Website Not Available www.mgchemicals.com Email [email protected] [email protected] 1.4. Emergency telephone number Association / Organisation Verisk 3E (Access code: 335388) Not Available Emergency telephone numbers +(44) 20 35147487 Not Available Other emergency telephone +(0) 800 680 0425 Not Available numbers SECTION 2 HAZARDS IDENTIFICATION 2.1. Classification of the substance or mixture Classification according to regulation (EC) No 1272/2008 H319 - Eye Irritation Category 2, H317 - Skin Sensitizer Category 1, H334 - Respiratory Sensitizer Category 1 [CLP] [1] 1. Classified by Chemwatch; 2. Classification drawn from EC Directive 67/548/EEC - Annex I ; 3. -
Other Data Relevant to an Evaluation of Carcinogenicity and Its Mechanisms
WOOD DUST 173 3.5 Experimental data on wood shavings It has been suggested in several studies that cedar wood shavings, used as bedding for animaIs, are implicated in the prominent differences in the incidences of spontaneous liver and mammar tumours in mice, mainly of the C3H strain, maintained in different laboratories (Sabine et al., 1973; Sabine, 1975). Others (Heston, 1975) have attributed these variations in incidence to different conditions of animal maintenance, such as food consumption, infestation with ectoparasites and general condition of health, rather than to use of cedar shavings as bedding. Additional attempts to demonstrate carcinogenic properties of cedar shavings used as bedding materIal for mice of the C3H (Vlahakis, 1977) and SWJ/Jac (Jacobs & Dieter, 1978) strains were not successful. ln no ne of these studies were there control groups not exposed to cedar shavings. 4. Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms 4.1 Deposition and clearance 4.1.1 Humans No studies of the deposition of wood dust in human airways were available to the Working Group. Particle deposition in the airways has been the object of several studies (for reviews, see Brain & Valberg, 1979; Warheit, 1989). Large particles (? 10 ¡.m) are almost entirely deposited in the nose; the deposition of smaUer particles depends on size but also on flow rates and type of breathing (mouth or nose); there is also inter-individual variation (Technical Committee of the Inhalation Specialty Section, Society of T oxicology, 1987). Particles deposited in the nasal airways are removed by mucociliary transport (for reviews, see Proctor, 1982; Warheit, 1989). -
Proposal for Identification of a Substance As a Cmr, Pbt
ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO. 80 TC NES SUBGROUP ON IDENTIFICATION OF PBT AND VPVP SUBSTANCES RESULTS OF THE EVALUATION OF THE PBT/VPVB PROPERTIES OF: Substance name: Resin acids and Rosin acids, sodium salts EC number: 263-144-5 CAS number: 61790-51-0 Molecular formula: not applicable (substance is a UVCB) Structural formula: not applicable (substance is a UVCB) Summary of the evaluation Resin acids and Rosin acids, sodium salts is considered to be a UVCB substance. Based on screening data it is not fulfilling the PBT/vPvB criteria. Resin acids and Rosin acids, sodium salts is considered as a substance with a potential PBT/vPvB constituent (based on screening data). This conclusion need not apply in case it can be shown, that the concentration of this impurity is < 0.1% w/w. Resin acids and Rosin acids, sodium salts may contain sesquiterpenes (which itself is a mixture) as a constituent, which may fulfil the PBT criteria based on QSAR-estimates of the most common sesquiterpene β –caryophyllane. A test on ready biodegradation is available with Resin acids and Rosin acids, sodium salts showing ready biodegradation of the test substance. The P-screening criterion is therefore not fulfilled. Regarding the B-criterion, only QSAR values are available both with respect to the log Kow and the BCF. BCFwin and Kowwin predict different values for Log Kow; 6.46 and 2.65, respectively. The calculated BCF is 56, when using a log Kow of 6.46 for calculation. The B-screening criterion is therefore not fulfilled. -
Titelei 1 1..14
XII Contents Contents Endorsement V Preface VII Chapter 1 Alkaloids 1 1.1 Nicotine from Tobacco 3 1.2 Caffeine from Green Tea and Green Coffee Beans 25 1.3 Theobromine from Cocoa Powder 39 1.4 Piperine from Black Pepper 53 1.5 Cytisine from Seeds of the Golden Chain Tree 65 1.6 Galanthamine from the Bulbs of Daffodils “Carlton” 83 1.7 Strychnine from Seeds of the Strychnine Tree 103 Chapter 2 Aromatic Compounds 129 2.1 Anethole from Ouzo, containing Anise Extract 131 2.2 Eugenol from Cloves 143 2.3 Chamazulene from German Chamomile Flowers 153 2.4 Tetrahydrocannabinol from Marijuana 169 Chapter 3 Dyestuffs and Coloured Compounds 189 3.1 Lawsone from Henna Leaves Powder 191 3.2 Curcumin from Turmeric 207 3.3 Brazileine from Pernambuco Wood 221 3.4 Indigo from Woad 241 3.5 Capsanthin from Sweet Pepper Powder 261 Chapter 4 Carbohydrates 283 4.1 Glucosamine from the shells of common shrimps 285 4.2 Lactose from Milk 303 4.3 Amygdalin from Bitter Almonds 319 4.4 Hesperidin from the Peel of Mandarin Oranges 335 Contents XIII Chapter 5 Terpenoids 357 5.1 Limonene from Brasilian Sweet Orange Oil 359 5.2 Menthol from Japanese Peppermint Oil 373 5.3 The Thujones from Common Sage or Wormwood 389 5.4 Patchouli Alcohol from Patchouli 409 5.5 Onocerin from Spiny Restharrow Roots 427 5.6 Cnicin from Blessed Thistle Leaves 443 5.7 Abietic Acid from Colophony of Pine Trees 459 5.8 Betulinic Acid from Plane-Tree Bark 481 Chapter 6 Miscellaneous 501 6.1 Shikimic Acid from Star Aniseed 503 6.2 Aleuritic Acid from Shellac 519 Answers to Questions and Translations -
United States Patent Office Patented Aug
3,523,090 United States Patent Office Patented Aug. 4, 1970 2 a “resin acid.” The structure and numbering system of levopimaric acid follows: 3,523,090 POLYURETHANE PLASTIC FROM RESIN ACID DIOLS Bernard A. Parkin, In, Lake City, Fla., Hugh B. Sum mers, Jr., Savannah, Ga., and Glen W. Hedrick, Lake City, Fla., assignors to the United States of America as represented by the Secretary of Agriculture No Drawing. Original application June 11, 1968, Ser. No. 562,951. Divided and this application Apr. 11, 1968, 10 Ser. No. 738,749 Int. Cl. (109k 3/00; H05b 33/00 US. Cl. 252-482 1 Claim 15 ABSTRACT OF THE DISCLOSURE A saturated diol prepared by the hydrolysis and the 20 subsequent double bond and functional group reduction of the formaldehyde adduct of levopimaric acid. The diol is a useful glycol extender for the production of poly urethane foams and rubbers. 25 / Levopimaric acid (I) A non-exclusive, irrevocable, royalty-free license in the 30 The nomenclature is that of Fieser and Fieser (Nat invention herein described, throughout the world for all ural Products Related to Phenanthrene by Fieser and purpose of the United States Government, with the power Fieser, third edition, 1949, page 40, Published by Rein to grant sublicenses for such purposes, is hereby granted hold Publishing Corporation, New York, N.Y.) to the Government of the United States of America. As noted above, levopimaric acid (I) constitutes about This application is a division of application bearing one-?fth of the total acid content of pine gum. As will Ser. -
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(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization llllllllllllllllllllllllllllllll^ International Bureau (10) International Publication Number (43) International Publication Date WO 2018/144996 Al 09 August 2018 (09.08.2018) WIPO I PCT (51) International Patent Classification: GHOSH, Souvik; c/o Manus Bio, Inc., 1030 Massachusetts C12N1/00 (2006.01) C12N15/00(2006.01) Avenue, Cambridge, MA 02138 (US). PIRIE, Christo C12N1/20 (2006.01) C12N15/52 (2006.01) pher; c/o Manus Bio, Inc., 1030 Massachusetts Avenue, C12N1/21 (2006.01) C12P 5/00 (2006.01) Cambridge, MA 02138 (US). DONAUD, Jason; c/o Manus C12N 9/00 (2006.01) Bio, Inc., 1030 Massachusetts Avenue, Cambridge, MA 02138 (US). UOVE, Aaron; c/o Manus Rio, Inc., 1030 (21) International Application Number: Massachusetts Avenue, Cambridge, MA 02138 (US). NAN, PCT/US2018/016848 Hong; c/o Manus Rio, Inc., 1030 Massachusetts Avenue, (22) International Filing Date: Cambridge, MA 02138 (US). TSENG, Hsien-chung; c/ 05 February 2018 (05.02.2018) o Manus Rio, Inc., 1030 Massachusetts Avenue, Cam bridge, MA 02138 (US). SANTOS, Christine Nicole, S.; (25) Filing Language: English c/o Manus Rio, Inc., 1030 Massachusetts Avenue, Cam (26) Publication Language: English bridge, MA 02138 (US). PHIUIPPE, Ryan; c/o Manus Rio, Inc., 1030 Massachusetts Avenue, Cambridge, MA 02138 (30) Priority Data: (US). 62/454,121 03 February 2017 (03.02.2017) US (74) Agent: HAYMAN, Mark, U. et al.; Morgan, Lewis & (71) Applicant: MANUS BIO, INC. [US/US]; 1030 Massachu Bockius LLP, 1111 Pennsylvania Avenue, NW, Washing setts Avenue, Cambridge, MA 02138 (US). -
Determination of Terpenoid Content in Pine by Organic Solvent Extraction and Fast-Gc Analysis
ORIGINAL RESEARCH published: 25 January 2016 doi: 10.3389/fenrg.2016.00002 Determination of Terpenoid Content in Pine by Organic Solvent Extraction and Fast-GC Analysis Anne E. Harman-Ware1* , Robert Sykes1 , Gary F. Peter2 and Mark Davis1 1 National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA, 2 School of Forest Resources and Conservation, University of Florida, Gainesville, FL, USA Terpenoids, naturally occurring compounds derived from isoprene units present in pine oleoresin, are a valuable source of chemicals used in solvents, fragrances, flavors, and have shown potential use as a biofuel. This paper describes a method to extract and analyze the terpenoids present in loblolly pine saplings and pine lighter wood. Various extraction solvents were tested over different times and temperatures. Samples were analyzed by pyrolysis-molecular beam mass spectrometry before and after extractions to monitor the extraction efficiency. The pyrolysis studies indicated that the optimal extraction method used a 1:1 hexane/acetone solvent system at 22°C for 1 h. Extracts from the hexane/acetone experiments were analyzed using a low thermal mass modular accelerated column heater for fast-GC/FID analysis. The most abundant terpenoids from Edited by: the pine samples were quantified, using standard curves, and included the monoter- Subba Rao Chaganti, University of Windsor, Canada penes, α- and β-pinene, camphene, and δ-carene. Sesquiterpenes analyzed included Reviewed by: caryophyllene, humulene, and α-bisabolene. Diterpenoid resin acids were quantified in Yu-Shen Cheng, derivatized extractions, including pimaric, isopimaric, levopimaric, palustric, dehydroabi- National Yunlin University of Science and Technology, Taiwan etic, abietic, and neoabietic acids. -
Chemical Composition Analysis, Antimicrobial Activity and Cytotoxicity Screening of Moss Extracts (Moss Phytochemistry)
Molecules 2015, 20, 17221-17243; doi:10.3390/molecules200917221 OPEN ACCESS molecules ISSN 1420-3049 www.mdpi.com/journal/molecules Article Chemical Composition Analysis, Antimicrobial Activity and Cytotoxicity Screening of Moss Extracts (Moss Phytochemistry) Laura Klavina 1,*, Gunta Springe 2, Vizma Nikolajeva 3, Illia Martsinkevich 4, Ilva Nakurte 4, Diana Dzabijeva 4 and Iveta Steinberga 1 1 Department of Environmental Science, University of Latvia, 19 Raina Blvd., Riga LV-1586, Latvia; E-Mail: [email protected] 2 Institute of Biology, University of Latvia, 3 Miera Street, Salaspils LV-2169, Latvia; E-Mail: [email protected] 3 Department of Microbiology and Biotechnology, University of Latvia, 4 Kronvalda Blvd., Riga LV-1010, Latvia; E-Mail: [email protected] 4 Faculty of Chemistry, University of Latvia, 19 Raina Blvd., Riga LV-1586, Latvia; E-Mails: [email protected] (I.M.); [email protected] (I.N.); [email protected] (D.D.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +371-283-480-67. Academic Editor: Derek J. McPhee Received: 29 July 2015 / Accepted: 10 September 2015 / Published: 18 September 2015 Abstract: Mosses have been neglected as a study subject for a long time. Recent research shows that mosses contain remarkable and unique substances with high biological activity. The aim of this study, accordingly, was to analyze the composition of mosses and to screen their antimicrobial and anticancer activity. The total concentration of polyphenols and carbohydrates, the amount of dry residue and the radical scavenging activity were determined for a preliminary evaluation of the chemical composition of moss extracts. -
Tc Nes Subgroup on Identification of Pbt and Vpvp Substances Results of The
ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO. 81 TC NES SUBGROUP ON IDENTIFICATION OF PBT AND VPVP SUBSTANCES RESULTS OF THE EVALUATION OF THE PBT/VPVB PROPERTIES OF: Substance name: Tall-oil rosin EC number: 232-484-6 CAS number: 8052-10-6 Molecular formula: not applicable (substance is a UVCB) Structural formula: not applicable (substance is a UVCB) Summary of the evaluation: Tall-oil rosin is considered to be a UVCB substance. Based on screening data it is not fulfilling the PBT/vPvB criteria. A test on ready biodegradation is available with tall-oil rosin showing ready biodegradation of the test substance. The P-screening criterion is therefore not fulfilled. Regarding the B-criterion, an experimentally determined log Kow of 3.6 at pH 7 is available. Based on this value a BCF of 56 was calculated with QSAR. The B- screening criterion is therefore not fulfilled. Based on acute aquatic toxicity results with L/EC50 above 100 mg/L the screening T-criterion is not fulfilled. Data on individual constituents are not available. Based on QSAR there is no clear picture regarding persistence, bioaccumulation and toxicity because the constituents have pKa values around environmentally relevant pH values. However, no further testing is considered necessary as tall-oil rosin is readily biodegradable. Draft June 2008 1 ECB – SUMMARY FACT SHEET PBT WORKING GROUP – PBT LIST NO. 81 JUSTIFICATION 1 Identification of the Substance and physical and chemical properties Table 1.1: Identification of tall-oil rosin Name Tall-oil rosin EC Number 294-866-9 CAS Number 8052-10-6 IUPAC Name - Molecular Formula not applicable Structural Formula not applicable Molecular Weight not applicable Synonyms Colophony Colofonia Kolophonium Rosin Résine, Tall-oil, Tallharz Tallharz, Mäntyhartsi, Talloljaharts, OULU 331 1.1 Purity/Impurities/Additives Tall-oil resin (CAS no.