February 1, 2011 u vol. 108 u no. 5 u 1747–2172

Cover image: Pictured is an eyeball camera with a tunable lens and detector that allow for adjustable zoom. Inhwa Jung et al. fabricated a digital imaging device that contains photo- detector arrays on a deformable elastic polymer. The arrays allow the device to match the curvature of the detectors with that of the image surface. The compact, hemispherical camera with adjustable zoom and wide-angle view fields could be used in a range of applications, such as night surveillance and endoscopic imaging. See the article by Jung et al. on pages 1788–1793. Image courtesy of Inhwa Jung and Alex Jerez (Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL). From the Cover

1788 Eyeball camera with elastic arrays 1763 Quelling free radicals 1771 Balance in social networks 1783 Modeling traveling waves 1815 Colonization of East Polynesia

1753 Recalibrating Polynesian prehistory Contents John Edward Terrell See companion article on page 1815

THIS WEEK IN PNAS INAUGURAL ARTICLE 1747 In This Issue

1755 Regulation of imprinted gene expression in LETTERS (ONLINE ONLY) Arabidopsis endosperm Tzung-Fu Hsieh, Juhyun Shin, Rie Uzawa, Pedro Silva, Stephanie Cohen, Matthew J. Bauer, Meryl Hashimoto, E15 Monoclonal tumor origin is an underlying misconception Ryan C. Kirkbride, John J. Harada, Daniel Zilberman, of the RESIC approach and Robert L. Fischer Barbara L. Parsons E16 Reply to Parsons: Many tumor types follow the monoclonal model of tumor initiation FEATURE ARTICLE Yu-Kang Cheng, Rameen Beroukhim, Ross L. Levine, Ingo K. Mellinghoff, and Franziska Michor 1763 Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier COMMENTARIES Annemarthe G. Van der Veen, Kenji Schorpp, Christian Schlieker, Ludovico Buti, Jadyn R. Damon, Eric Spooner, Hidde L. Ploegh, and Stefan Jentsch 1749 Urm1 couples sulfur transfer to ubiquitin-like protein See Commentary on page 1749 function in oxidative stress Matthew D. Petroski, Guy S. Salvesen, and Dieter A. Wolf See companion article on page 1763 1751 Local balancing influences global structure in PHYSICAL SCIENCES social networks Aravind Srinivasan APPLIED MATHEMATICS See companion article on page 1771 1771 Continuous-time model of structural balance Seth A. Marvel, Jon Kleinberg, Robert D. Kleinberg, and Steven H. Strogatz Free online through the PNAS open access option. See Commentary on page 1751

PNAS u February 1, 2011 u vol. 108 u no. 5 u iii–vii Downloaded by guest on September 29, 2021 APPLIED PHYSICAL SCIENCES ECONOMIC SCIENCES 1777 Noncontact estimation of intercellular breaking force 1821 Being surveyed can change later behavior and related using a femtosecond laser impulse quantified by parameter estimates atomic force microscopy Alix Peterson Zwane, Jonathan Zinman, Eric Van Dusen, Yoichiroh Hosokawa, Man Hagiyama, Takanori Iino, William Pariente, Clair Null, Edward Miguel, Michael Yoshinori Murakami, and Akihiko Ito Kremer, Dean S. Karlan, Richard Hornbeck, Xavier Giné, Esther Duflo, Florencia Devoto, Bruno Crepon, 1783 The noisy edge of traveling waves and Abhijit Banerjee Oskar Hallatschek

1788 Dynamically tunable hemispherical electronic eye SOCIAL SCIENCES camera system with adjustable zoom capability 1993 Correlated genotypes in friendship networks Inhwa Jung, Jianliang Xiao, Viktor Malyarchuk, Chaofeng Lu, James H. Fowler, Jaime E. Settle, and Nicholas A. Christakis Ming Li, Zhuangjian Liu, Jongseung Yoon, Yonggang Huang, and John A. Rogers

CHEMISTRY BIOLOGICAL SCIENCES 1794 Populations of the three major backbone conformations in 19 amino acid dipeptides APPLIED BIOLOGICAL SCIENCES Joze Grdadolnik, Vlasta Mohacek-Grosev, 1827 Modulation of cardiac macrophages by Robert L. Baldwin, and Franc Avbelj phosphatidylserine-presenting liposomes improves infarct repair 1874 Reconciliation of opposing views on Tamar Harel-Adar, Tamar Ben Mordechai, Yoram membrane–sugar interactions Amsalem, Micha S. Feinberg, Jonathan Leor, Heidi D. Andersen, Chunhua Wang, Lise Arleth, and Smadar Cohen Günther H. Peters, and Peter Westh

1955 Chemical basis of the synergism and antagonism in BIOCHEMISTRY microbial communities in the nests of leaf-cutting ants 1833 Trinitrophenyl derivatives bind differently from Ilka Schoenian, Michael Spiteller, Manoj Ghaste, parent adenine nucleotides to Ca2+-ATPase in Rainer Wirth, Hubert Herz, and Dieter Spiteller the absence of Ca2+ Chikashi Toyoshima, Shin-Ichiro Yonekura, ENGINEERING Junko Tsueda, and Shiho Iwasawa 1799 Scaling rules for diffusive drug delivery in tumor and normal tissues 1839 Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) James W. Baish, Triantafyllos Stylianopoulos, Ryan M. RNAs bound to the 70S ribosome Lanning, Walid S. Kamoun, Dai Fukumura, Lance L. Munn, and Rakesh K. Jain Jianyu Zhu, Andrei Korostelev, David A. Costantino, John P. Donohue, Harry F. Noller, and Jeffrey S. Kieft

PHYSICS 1845 Architecture of the DNA polymerase B-proliferating cell 1804 From polariton condensates to highly photonic quantum nuclear antigen (PCNA)-DNA ternary complex degenerate states of bosonic matter Kouta Mayanagi, Shinichi Kiyonari, Hirokazu Nishida, Marc Aßmann, Jean-Sebastian Tempel, Franziska Veit, Mihoko Saito, Daisuke Kohda, Yoshizumi Ishino, Manfred Bayer, Arash Rahimi-Iman, Andreas Löffler, Tsuyoshi Shirai, and Kosuke Morikawa Sven Höfling, Stephan Reitzenstein, Lukas Worschech, and Alfred Forchel 1850 Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo 1810 Colloidal quasicrystals with 12-fold and 18-fold Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, diffraction symmetry and Omid C. Farokhzad Steffen Fischer, Alexander Exner, Kathrin Zielske, Jan Perlich, Sofia Deloudi, Walter Steurer, 1856 Structure, function and latency regulation of a bacterial Peter Lindner, and Stephan Förster enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog Theodoros Goulas, Joan L. Arolas, and F. Xavier Gomis-Rüth

SOCIAL SCIENCES 1862 Replication infidelity via a mismatch with Watson–Crick geometry Katarzyna Bebenek, Lars C. Pedersen, ANTHROPOLOGY and Thomas A. Kunkel 1815 High-precision radiocarbon dating shows recent and rapid initial human colonization of East Polynesia 1868 Interactions of anthrax lethal factor with protective Janet M. Wilmshurst, Terry L. Hunt, Carl P. Lipo, antigen defined by site-directed spin labeling and Atholl J. Anderson Laura D. Jennings-Antipov, Likai Song, See Commentary on page 1753 and R. John Collier

iv u www.pnas.org Downloaded by guest on September 29, 2021 BIOPHYSICS AND COMPUTATIONAL BIOLOGY 1925 Methyltransferase Set7/9 regulates p53 activity by 1777 Noncontact estimation of intercellular breaking force interacting with Sirtuin 1 (SIRT1) using a femtosecond laser impulse quantified by Xiangyu Liu, Donglai Wang, Ying Zhao, Bo Tu, atomic force microscopy Zhixing Zheng, Lina Wang, Haiying Wang, Wei Gu, Yoichiroh Hosokawa, Man Hagiyama, Takanori Iino, Robert G. Roeder, and Wei-Guo Zhu Yoshinori Murakami, and Akihiko Ito 1931 VHL loss in renal cell carcinoma leads to up-regulation 1874 Reconciliation of opposing views on of CUB domain-containing protein 1 to stimulate δ membrane–sugar interactions PKC -driven migration Heidi D. Andersen, Chunhua Wang, Lise Arleth, Olga V. Razorenova, Elizabeth C. Finger, Renata Colavitti, Günther H. Peters, and Peter Westh Sophia B. Chernikova, Alexander D. Boiko, Charles K. F. Chan, Adam Krieg, Barbara Bedogni, Edward LaGory, 1879 Optimal pulse design in quantum control: A unified Irving L. Weissman, Marianne Broome-Powell, computational method and Amato J. Giaccia Jr-Shin Li, Justin Ruths, Tsyr-Yan Yu, Haribabu Arthanari, and Gerhard Wagner 1937 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere β 1885 Tension-dependent structural deformation alters with its function in down-regulating -catenin single-molecule transition kinetics Marc Fiedler, Carolina Mendoza-Topaz, Trevor J. B. Sudhanshu, S. Mihardja, E. F. Koslover, S. Mehraeen, Rutherford, Juliusz Mieszczanek, and Mariann Bienz C. Bustamante, and A. J. Spakowitz 1943 Contractility of the cell rear drives invasion of breast 1891 Structural kinetics of myosin by transient tumor cells in 3D Matrigel time-resolved FRET Renaud Poincloux, Olivier Collin, Floria Lizárraga, Yuri E. Nesmelov, Roman V. Agafonov, Igor V. Maryse Romao, Marcel Debray, Matthieu Piel, Negrashov, Sarah E. Blakely, Margaret A. Titus, and Philippe Chavrier and David D. Thomas 1949 Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure Laurent Sansregret, Charles Vadnais, Julie Livingstone, CELL BIOLOGY Nicholas Kwiatkowski, Arif Awan, Chantal Cadieux, 1763 Role of the ubiquitin-like protein Urm1 as a noncanonical Lam Leduy, Michael T. Hallett, and Alain Nepveu lysine-directed protein modifier Annemarthe G. Van der Veen, Kenji Schorpp, Christian Schlieker, Ludovico Buti, Jadyn R. Damon, Eric Spooner, Hidde L. Ploegh, and Stefan Jentsch ECOLOGY See Commentary on page 1749 1955 Chemical basis of the synergism and antagonism in microbial communities in the nests of leaf-cutting ants 1897 RA-inducible gene-I induction augments STAT1 Ilka Schoenian, Michael Spiteller, Manoj Ghaste, activation to inhibit leukemia cell proliferation Rainer Wirth, Hubert Herz, and Dieter Spiteller Lin-Jia Jiang, Nan-Nan Zhang, Fei Ding, Xian-Yang Li, Lei Chen, Hong-Xin Zhang, Wu Zhang, Sai-Juan Chen, 1961 Climate and population density drive changes in cod Zhu-Gang Wang, Jun-Min Li, Zhu Chen, and Jiang Zhu body size throughout a century on the Norwegian coast Lauren A. Rogers, Leif C. Stige, Esben M. Olsen, Halvor 1903 Membrane lipidome of an epithelial cell line Knutsen, Kung-Sik Chan, and Nils Chr. Stenseth Julio L. Sampaio, Mathias J. Gerl, Christian Klose, Christer S. Ejsing, Hartmut Beug, Kai Simons, 1967 Climate change induces demographic resistance to and Andrej Shevchenko disease in novel coral assemblages Laith Yakob and Peter J. Mumby 1908 PDGF-BB and TGF-β1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced 1970 Determinants of lemming outbreaks by low shear stress Rolf A. Ims, Nigel G. Yoccoz, and Siw T. Killengreen Ying-Xin Qi, Jun Jiang, Xiao-Hua Jiang, Xiao-Dong Wang, Su-Ying Ji, Yue Han, Ding-Kun Long, Bao-Rong Shen, 1975 Strong evidence for terrestrial support of zooplankton Zhi-Qiang Yan, Shu Chien, and Zong-Lai Jiang in small lakes based on stable isotopes of carbon, nitrogen, and hydrogen 1914 Wild-type LRP6 inhibits, whereas atherosclerosis-linked Jonathan J. Cole, Stephen R. Carpenter, Jim Kitchell, LRP6R611C increases PDGF-dependent vascular smooth Michael L. Pace, Christopher T. Solomon, muscle cell proliferation and Brian Weidel Ali R. Keramati, Rajvir Singh, Aiping Lin, Saeed Faramarzi, Zhi-jia Ye, Shrikant Mane, George Tellides, Richard P. Lifton, and Arya Mani ENVIRONMENTAL SCIENCES 1919 Epstein-Barr virus nuclear antigens 3C and 3A maintain 1981 Cellulose δ18O is an index of leaf-to-air vapor lymphoblastoid cell growth by repressing p16INK4A and pressure difference (VPD) in tropical plants p14ARF expression Ansgar Kahmen, Dirk Sachse, Stefan K. Arndt, Seiji Maruo, Bo Zhao, Eric Johannsen, Elliott Kieff, Kevin P. Tu, Heraldo Farrington, Peter M. Vitousek, James Zou, and Kenzo Takada and Todd E. Dawson

PNAS u February 1, 2011 u vol. 108 u no. 5 u v Downloaded by guest on September 29, 2021 EVOLUTION 2052 Low body temperature governs the decline of circulating 1783 The noisy edge of traveling waves lymphocytes during hibernation through Oskar Hallatschek sphingosine-1-phosphate Hjalmar R. Bouma, Frans G. M. Kroese, Jan Willem Kok, 1987 Outcrossing, mitotic recombination, and life-history Fatimeh Talaei, Ate S. Boerema, Annika Herwig, Oana trade-offs shape genome evolution in Draghiciu, Azuwerus van Buiten, Anne H. Epema, Annie Saccharomyces cerevisiae van Dam, Arjen M. Strijkstra, and Robert H. Henning Paul M. Magwene, Ömür Kayıkçı, Joshua A. Granek, Jennifer M. Reininga, Zackary Scholl, and Debra Murray MEDICAL SCIENCES 1799 Scaling rules for diffusive drug delivery in tumor and GENETICS normal tissues 1993 Correlated genotypes in friendship networks James W. Baish, Triantafyllos Stylianopoulos, Ryan M. James H. Fowler, Jaime E. Settle, and Nicholas A. Christakis Lanning, Walid S. Kamoun, Dai Fukumura, Lance L. Munn, and Rakesh K. Jain 1998 SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans 1821 Being surveyed can change later behavior and related Brendan D. Galvin, Daniel P. Denning, and H. Robert Horvitz parameter estimates Alix Peterson Zwane, Jonathan Zinman, Eric Van Dusen, 2004 Dynamic histone acetylation is critical for William Pariente, Clair Null, Edward Miguel, Michael cotranscriptional spliceosome assembly and Kremer, Dean S. Karlan, Richard Hornbeck, Xavier Giné, spliceosomal rearrangements Esther Duflo, Florencia Devoto, Bruno Crepon, Felizza Q. Gunderson, Evan C. Merkhofer, and Abhijit Banerjee and Tracy L. Johnson 2058 High-throughput ectopic expression screen for IMMUNOLOGY tamoxifen resistance identifies an atypical kinase that blocks autophagy 2010 CD8+ T regulatory cells express the Ly49 Class I MHC Laura Gonzalez-Malerva, Jaehong Park, Lihua Zou, receptor and are defective in autoimmune prone Yanhui Hu, Zahra Moradpour, Joseph Pearlberg, B6-Yaa mice Jacqueline Sawyer, Hallam Stevens, Ed Harlow, Hye-Jung Kim, Xuan Wang, Soroosh Radfar, Thomas J. and Joshua LaBaer Sproule, Derry C. Roopenian, and Harvey Cantor

2016 Killer cell Ig-like receptor (KIR) 3DL1 down-regulation 2064 Coexpression of VEGF and angiopoietin-1 promotes enhances inhibition of type 1 diabetes by angiogenesis and cardiomyocyte proliferation reduces autoantigen-specific regulatory T cells apoptosis in porcine myocardial infarction (MI) heart Hanjun Qin, Zunde Wang, Weiting Du, Wen-Hui Lee, Zhengxian Tao, Bo Chen, Xiao Tan, Yingming Zhao, Xiwei Wu, Arthur D. Riggs, and Chih-Pin Liu Liansheng Wang, Tiebing Zhu, Kejiang Cao, Zhijian Yang, Yuet Wai Kan, and Hua Su 2022 Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal 2070 A modest decrease in endothelial NOS in mice signal joint formation comparable to that associated with human NOS3 Eric J. Gapud, Yair Dorsett, Bu Yin, Elsa Callen, Andrea variants exacerbates diabetic nephropathy Bredemeyer, Grace K. Mahowald, Kazuo Q. Omi, Laura M. Chih-Hong Wang, Feng Li, Sylvia Hiller, Hyung-Suk Kim, Walker, Jeffrey J. Bednarski, Peter J. McKinnon, Craig H. Nobuyo Maeda, Oliver Smithies, and Nobuyuki Takahashi Bassing, Andre Nussenzweig, and Barry P. Sleckman 2076 Differential regulation of the p73 cistrome by 2028 Ataxia telangiectasia-mutated protein and DNA- mammalian target of rapamycin reveals dependent protein kinase have complementary transcriptional programs of mesenchymal V(D)J recombination functions differentiation and tumorigenesis Shan Zha, Wenxia Jiang, Yuko Fujiwara, Harin Patel, Jennifer M. Rosenbluth, Deborah J. Mays, Aixiang Jiang, Peter H. Goff, James W. Brush, Richard L. Dubois, Yu Shyr, and Jennifer A. Pietenpol and Frederick W. Alt 2082 Neonatal helper-dependent adenoviral vector gene 2034 HRD1 and UBE2J1 target misfolded MHC class I heavy therapy mediates correction of hemophilia A and chains for endoplasmic reticulum-associated tolerance to human factor VIII degradation Chuhong Hu, Racel G. Cela, Masataka Suzuki, Marian L. Burr, Florencia Cano, Stanislava Svobodova, Brendan Lee, and Gerald S. Lipshutz Louise H. Boyle, Jessica M. Boname, and Paul J. Lehner 2088 Uric acid is a danger signal of increasing risk for 2040 Neuropilin-1 attenuates autoreactivity in experimental osteoarthritis through inflammasome activation autoimmune encephalomyelitis Anna E. Denoble, Kim M. Huffman, Thomas V. Stabler, Benjamin D. Solomon, Cynthia Mueller, Wook-Jin Chae, Susan J. Kelly, Michael S. Hershfield, Gary E. McDaniel, Leah M. Alabanza, and Margaret S. Bynoe R. Edward Coleman, and Virginia B. Kraus

2046 LTβR signaling in dendritic cells induces a type I IFN 2094 Bitter taste receptors and α-gustducin regulate the response that is required for optimal clonal secretion of ghrelin with functional effects on food expansion of CD8+ T cells intake and gastric emptying Leslie Summers deLuca, Dennis Ng, Yunfei Gao, Michael E. Sara Janssen, Jorien Laermans, Pieter-Jan Verhulst, Wortzman, Tania H. Watts, and Jennifer L. Gommerman Theo Thijs, Jan Tack, and Inge Depoortere

vi u www.pnas.org Downloaded by guest on September 29, 2021 2100 Gastrin-releasing peptide blockade as a broad-spectrum NEUROSCIENCE fl anti-in ammatory therapy for asthma 2142 Regional rescue of spinocerebellar ataxia type 1 Shutang Zhou, Erin N. Potts, Frank Cuttitta, phenotypes by 14-3-3ε haploinsufficiency in W. Michael Foster, and Mary E. Sunday mice underscores complex pathogenicity in neurodegeneration Paymaan Jafar-Nejad, Christopher S. Ward, Ronald Richman, MICROBIOLOGY Harry T. Orr, and Huda Y. Zoghbi 2106 Signal integration by DegS and RseB governs the 2148 Roller Coaster Scanning reveals spontaneous triggering σE-mediated envelope stress response in Escherichia coli of dendritic spikes in CA1 interneurons Rachna Chaba, Benjamin M. Alba, Monica S. Guo, Jungsan Gergely Katona, Attila Kaszás, Gergely F. Turi, Norbert Sohn, Nidhi Ahuja, Robert T. Sauer, and Carol A. Gross Hájos, Gábor Tamás, E. Sylvester Vizi, and Balázs Rózsa 2112 Structures of sequential open states in a symmetrical opening transition of the TolC exit duct PLANT BIOLOGY Xue-Yuan Pei, Philip Hinchliffe, Martyn F. Symmons, Eva Koronakis, Roland Benz, Colin Hughes, 1755 Regulation of imprinted gene expression in and Vassilis Koronakis Arabidopsis endosperm Tzung-Fu Hsieh, Juhyun Shin, Rie Uzawa, Pedro Silva, 2118 Activation of IFN-β expression by a viral mRNA through Stephanie Cohen, Matthew J. Bauer, Meryl Hashimoto, RNase L and MDA5 Ryan C. Kirkbride, John J. Harada, Daniel Zilberman, Priya Luthra, Dengyun Sun, Robert H. Silverman, and Robert L. Fischer and Biao He 2154 ORGAN BOUNDARY1 defines a gene expressed at the 2124 An experimentally anchored map of transcriptional start junction between the shoot apical meristem and sites in the model cyanobacterium Synechocystis lateral organs sp. PCC6803 Euna Cho and Patricia C. Zambryski Jan Mitschke, Jens Georg, Ingeborg Scholz, Cynthia M. 2160 SCARECROW-LIKE 3 promotes gibberellin signaling by Sharma, Dennis Dienst, Jens Bantscheff, Björn Voß, Claudia antagonizing master growth repressor DELLA Steglich, Annegret Wilde, Jörg Vogel, and Wolfgang R. Hess in Arabidopsis 2130 Human papillomavirus E7 oncoprotein induces KDM6A Zhong-Lin Zhang, Mikihiro Ogawa, Christine M. Fleet, and KDM6B histone demethylase expression and Rodolfo Zentella, Jianhong Hu, Jung-Ok Heo, Jun Lim, causes epigenetic reprogramming Yuji Kamiya, Shinjiro Yamaguchi, and Tai-ping Sun Margaret E. McLaughlin-Drubin, Christopher P. Crum, 2166 Funneling of gibberellin signaling by the GRAS and Karl Münger transcription regulator SCARECROW-LIKE 3 in 2136 Brain angiogenesis inhibitor 1 (BAI1) is a pattern the Arabidopsis root recognition receptor that mediates macrophage binding Jung-Ok Heo, Kwang Suk Chang, In A Kim, Mi-Hyun Lee, and engulfment of Gram-negative bacteria Shin Ae Lee, Sang-Kee Song, Myeong Min Lee, and Jun Lim Soumita Das, Katherine A. Owen, Kim T. Ly, Daeho Park, Steven G. Black, Jeffrey M. Wilson, Costi D. Sifri, Kodi S. Ravichandran, Peter B. Ernst, and James E. Casanova ix Subscription Form

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