DOCSLIB.ORG

Malignant Fibrothecomatous Tumour of the Ovary

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Malignant Fibrothecomatous Tumour of the Ovary 868 J Clin Pathol 1998;51:868–871 Malignant fibrothecomatous tumour of the ovary: J Clin Pathol: first published as 10.1136/jcp.51.11.868 on 1 November 1998. Downloaded from diagnostic value of anti-inhibin immunostaining W G McCluggage, J M Sloan, D D Boyle, P G Toner Abstract ultrasound scan, which also revealed free fluid Malignant ovarian tumours of the fibro- in the pelvic cavity. Serum CA-125 was mark- thecoma group are rare. The clinico- edly raised at 196 U/ml. A presumptive pathological features of a case of ovarian diagnosis of ovarian cancer was made. At malignant fibrothecoma in which there laparotomy, tumour masses were present in the was metastatic disease in the small intes- right ovary and in the terminal ileum. There tine and peritoneum at presentation are were also multiple tumour nodules throughout described. A number of diVerential diag- the abdominal peritoneum. The clinical im- noses were considered but positive immu- pression was of a primary lesion in the right nohistochemical staining of the resected ovary, with small intestinal and peritoneal ovarian and small intestinal neoplasms metastases. Total abdominal hysterectomy and with anti-inhibin was of value in confirm- bilateral salpingo-oophorectomy was per- ing a sex cord–stromal tumour and in formed, together with resection of a length of excluding other lesions. The two tumours terminal ileum. The postoperative period was were also ultrastructurally identical. Clas- unremarkable and the patient is currently sical malignant fibrothecomas are said to undergoing chemotherapy. show four or more mitotic figures per 10 high power fields (HPF). Although the intestinal secondary was mitotically ac- tive, the primary ovarian tumour con- tained only one to two mitoses per 10 HPF, Methods showing that formal mitotic counts are The surgical specimen was fixed in formalin not an absolute indicator of malignant and sections for histological examination were behaviour in this group of tumours. routinely processed in paraYn wax and stained (J Clin Pathol 1998;51:868–871) with haematoxylin and eosin. Reticulin and oil-red O stains were performed on representa- Keywords: ovarian tumour; fibrothecoma; inhibin; tive sections of the ovarian and small intestinal immunohistochemistry tumours. A formal mitotic count was carried out on all histological sections of the ovarian http://jcp.bmj.com/ and small intestinal neoplasms. This was done Malignant ovarian tumours of the fibro- 1–4 by counting the number of mitotic figures in 50 thecoma group are exceedingly rare. They are generally classified as fibrosarcomas and high power fields (HPF) and calculating the there is doubt as to whether a true malignant average per 10 HPF. form of thecoma exists. The main histological Immunohistochemistry was performed feature said to be of importance in distinguish- using a standard streptavidin biotin–peroxidase method (Dako). Sections were stained with the ing a cellular fibrothecoma from fibrosarcoma on September 28, 2021 by guest. Protected copyright. is the degree of mitotic activity in the primary following monoclonal antibodies: inhibin (Se- tumour.2 In this report we describe an ovarian rotec), vimentin (Dako), CAM 5.2 (Becton fibrothecomatous tumour with metastatic dis- Dickinson), CA-125 (CIS Biointernational), ease in the small intestine and peritoneum. desmin (Dako), S-100 protein (Diagnostic Royal Group of Products), and á smooth muscle actin (Sigma). Hospitals Trust, Both the primary ovarian neoplasm and the Belfast, UK: intestinal metastasis were histologically and The anti-inhibin antibody is a mouse mono- Department of ultrastructurally indistinguishable from a cellu- clonal antibody against the á subunit of human Pathology lar fibrothecoma. There were only scattered inhibin. Immunohistochemistry was per- W G McCluggage mitotic figures in the ovarian lesion, although formed using appropriate positive and negative J M Sloan the intestinal secondary was more mitotically controls. For anti-inhibin staining, positive P G Toner active. A number of diVerential diagnoses were controls comprised ovaries containing follicu- Department of considered. Positive immunohistochemical lar cysts or corpora lutea. For negative controls, Obstetrics and staining of both lesions with anti-inhibin the primary antiserum was replaced by mouse Gynaecology assisted in classifying the neoplasm as a malig- immunoglobulin (IgG, Dako) at a comparable DDBoyle nant ovarian sex cord–stromal tumour. protein concentration. For comparison, three Correspondence to: cases each of leiomyosarcoma and gastro- Dr W G McCluggage, Case report intestinal stromal tumour were also stained Department of Pathology, with anti-inhibin. Royal Group of Hospitals A 61 year old postmenopausal woman pre- Trust, Grosvenor Road, sented with a three month history of general Representative pieces of formalin fixed tissue Belfast BT12 6BL, Northern malaise and melaena. Rectal examination sug- from both the ovarian and small intestinal Ireland, UK. gested a pelvic mass and she was referred to a tumours were processed for examination by Accepted for publication gynaecologist. The presence of a large mass electron microscopy. Ultrathin sections were 23 June 1998 filling the pelvis was confirmed by transvaginal stained with uranyl acetate and lead citrate. Anti-inhibin immunostaining in ovarian tumour 869 showed a cellular lesion. Tumour cell nuclei J Clin Pathol: first published as 10.1136/jcp.51.11.868 on 1 November 1998. Downloaded from were ovoid to spindle shaped and contained evenly dispersed chromatin (fig 1A). Neither nuclear grooves nor Call-Exner bodies were identified and there was little nuclear pleomor- phism. Numerous hyalinised plaques were present and there were areas of oedema. There was no haemorrhage or necrosis. Scattered mitotic figures were identified (fig 1B), a formal mitotic count revealing one to two per 10 HPF. The reticulin stain revealed a pericel- lular arrangement of fibres and numerous cytoplasmic lipid droplets were seen with the oil-red O stain. The histological features were in keeping with a cellular fibrothecoma. Histological examination of the left ovary showed a few microscopic foci of tumour, similar to that in the right ovary, on the exter- nal surface. In areas, tumour cells had abundant eosinophilic cytoplasm, in keeping with luteinisation. Given their multifocality and location on the external surface, these were presumed to represent metastatic disease rather than independent primary tumours. The fallopian tubes were unremarkable. The en- dometrium showed definite proliferative activ- ity with nuclear stratification and mitotic activ- ity. However, there was no hyperplasia or malignancy. The presence of two benign intra- mural fibroids was confirmed. No microscopic abnormality was identified within the cervix. Histological examination of multiple sec- tions from the tumour in the small intestine confirmed that it was mainly located on the serosal surface, but also invaded the muscularis propria and submucosa and focally ulcerated the mucosa (fig 1C). There were areas of haemorrhage and necrosis. Tumour cell nuclei were similar to those in the right ovarian http://jcp.bmj.com/ neoplasm, but focally there was a much higher mitotic rate, a formal mitotic count revealing areas in which there were 12–15 mitoses per 10 HPF. Several microscopic foci of metastatic tumour were identified adjacent to the main secondary tumour mass. Figure 1 (A) Ovarian tumour showing a cellular spindle IMMUNOHISTOCHEMICAL FINDINGS on September 28, 2021 by guest. Protected copyright. cell lesion with hyalinised plaques. (B) Higher power of The immunophenotypes of the right ovarian ovarian tumour. An occasional mitotic figure (arrow) is and small intestinal neoplasms were identical. present. (C) Metastatic lesion in small intestine. Tumour is situated under the mucosal surface. There was positive cytoplasmic staining with anti-inhibin (fig 2) and vimentin, but no stain- Results ing with the other antibodies employed. The PATHOLOGICAL FINDINGS three leiomyosarcomas and the three gastro- The surgical specimen consisted of a uterus intestinal stromal tumours were all negative and cervix with attached ovaries and fallopian with anti-inhibin. tubes. An 8 cm length of small intestine was also received. The right ovary was replaced by ELECTRONMICROSCOPY a solid, yellow coloured tumour which weighed Ultrastructural examination of the ovarian and 80 g and measured 7 cm in maximum small intestinal tumours showed identical diameter. The left ovary weighed6gand features. Tumour cells contained ovoid to spin- measured 3 cm in maximum diameter. It was dle shaped nuclei and a moderate amount of grossly unremarkable. The uterus contained cytoplasm. Lipid droplets, both intracellular two intramural fibroids, both measuring 1 cm and extracellular, were easily identified. Poorly in maximum diameter. A 9 cm diameter formed adhesion specialisations were present partially necrotic tumour was present in the between adjacent cells. A discontinuous exter- small intestine. This was mainly located on the nal lamina appeared at the cell surface in some serosal surface, but infiltrated the wall and areas and there were scattered collagen fibrils focally ulcerated the mucosa. in the interstitium. There was no ultrastruc- Histological examination of multiple sec- tural evidence of smooth muscle or neural dif- tions from the tumour in the right ovary ferentiation. 870 McCluggage, Sloan, Boyle, et al designated cellular fibroma, and a malignant J Clin Pathol: first published as 10.1136/jcp.51.11.868
Load more

Recommended publications
  • A Rare Presentation of Benign Brenner Tumor of Ovary: a Case Report
    International Journal of Reproduction, Contraception, Obstetrics and Gynecology Periasamy S et al. Int J Reprod Contracept Obstet Gynecol. 2018 Jul;7(7):2971-2974 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20182920 Case Report A rare presentation of benign Brenner tumor of ovary: a case report Sumathi Periasamy1, Subha Sivagami Sengodan2*, Devipriya1, Anbarasi Pandian2 1Department of Surgery, 2Department of Obstetrics and Gynaecology, Government Mohan Kumaramangalam Medical College, Salem, Tamil Nadu, India Received: 17 April 2018 Accepted: 23 May 2018 *Correspondence: Dr. Subha Sivagami Sengodan, E-mail: [email protected] Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Brenner tumors are rare ovarian tumors accounting for 2-3% of all ovarian neoplasms and about 2% of these tumors are borderline (proliferating) or malignant. These tumors are commonly seen in 4th-8th decades of life with a peak in late 40s and early 50s. Benign Brenner tumors are usually small, <2cm in diameter and often detected incidentally during surgery or on pathological examination. Authors report a case of a large, calcified benign Brenner tumor in a 55-year-old postmenopausal woman who presented with complaint of abdominal pain and mass in abdomen. Imaging revealed large complex solid cystic pelvic mass -peritoneal fibrosarcoma. She underwent laparotomy which revealed huge Brenner tumor weighing 9kg arising from left uterine cornual end extending up to epigastric region.
    [Show full text]
  • Collision Glial Neoplasms Arising in an Ovarian Mature Cystic Teratoma: a Rare Event
    Hindawi Case Reports in Pathology Volume 2020, Article ID 7568671, 4 pages https://doi.org/10.1155/2020/7568671 Case Report Collision Glial Neoplasms Arising in an Ovarian Mature Cystic Teratoma: A Rare Event Abdelrazak Meliti ,1,2 Bayan Hafiz,1 Haneen Al-Maghrabi ,1 and Abdulrahim Gari3 1Department of Anatomic Pathology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia 2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada 3Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia Correspondence should be addressed to Abdelrazak Meliti; [email protected] Received 26 September 2019; Accepted 27 January 2020; Published 3 February 2020 Academic Editor: Dimosthenis Miliaras Copyright © 2020 Abdelrazak Meliti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Germ cell neoplasms represent around 20% of all ovarian tumors. They most frequently affect children and young adults. Mature cystic teratoma is a common benign ovarian neoplasm comprising about 95% and is made up of all three germ cell embryonic layers. By definition, mature cystic teratoma may be derived from any of the three germ cell lines. On the other hand, immature teratomas contain primitive neuroepithelial elements. However, it is quite uncommon in the English literature to have a neuroepithelial glial neoplasm arising in a mature cystic teratoma of an adolescent. Interestingly enough, all published cases described a single type of glial neoplasm arising in mature ovarian teratoma.
    [Show full text]
  • Production of a Monoclonal Antibody Specific for Seminomas And
    Proc. Nati. Acad. Sci. USA Vol. 83, pp. 5291-5295, July 1986 Medical Sciences Production of a monoclonal antibody specific for seminomas and dysgerminomas (testicular and ovarian tumors/oncofetal antigen/glycoprotein/Mr 40,000 cell surface protein/immunoperoxidase) DENIS BAILEY*, REUBEN BAUMALt, JOHN LAWt, KATHERINE SHELDONt, PAUL KANNAMPUZHAt, MICHAEL STRATIS*, HARRIETTE KAHN§, AND ALEXANDER MARKSt *Departments of Pathology, Toronto General Hospital, MSG 1L7, tThe Hospital for Sick Children, M5G 1X8, tBanting and Best Department of Medical Research, University of Toronto, M5G 1L6, and §Women's College Hospital, Toronto, ON, Canada, M5S 1B2 Communicated by J. Tuzo Wilson, March 14, 1986 ABSTRACT A monoclonal antibody (M2A, IgG2a) was cultures in minimal essential medium alpha (Flow Laborato- produced against a cultured human ovarian epithelial adeno- ries) supplemented with 7% fetal bovine serum and 2 mM carcinoma cell line, HEY. Monoclonal antibody M2A reacted glutamine. with a glycoprotein of molecular weight 40,000 on the surface Human Normal Tissues and Tumors. Various normal tis- of HEY cells. The affinity constant of the monoclonal antibody sues and tumors were obtained from surgical biopsy speci- M2A for HEY cells was 109 M-1, and the number of binding mens processed in the departments of pathology at The sites on HEY cells was 2 x 104 per cell. The monoclonal Hospital for Sick Children, Toronto General Hospital and antibody produced positive immunoperoxidase staining offetal Women's College Hospital. (but not adult) testis and ofseminomas and dysgerminomas but Production of mAb. Eight-week-old female BALB/c mice did not stain various normal adult tissues or other gonadal or (Canadian Breeding Laboratories, Montreal, PQ) were im- extragonadal tumors.
    [Show full text]
  • Second Revised Proposed Regulation of the State
    SECOND REVISED PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 February 5, 2018 EXPLANATION – Matter in italics is new; matter in brackets [omitted material] is material to be omitted. AUTHORITY: §§1, 2, 4-9 and 11-15, NRS 457.065 and 457.240; §3, NRS 457.065 and 457.250; §10, NRS 457.065; §16, NRS 439.150, 457.065, 457.250 and 457.260. A REGULATION relating to cancer; revising provisions relating to certain publications adopted by reference by the State Board of Health; revising provisions governing the system for reporting information on cancer and other neoplasms established and maintained by the Chief Medical Officer; establishing the amount and the procedure for the imposition of certain administrative penalties by the Division of Public and Behavioral Health of the Department of Health and Human Services; and providing other matters properly relating thereto. Legislative Counsel’s Digest: Existing law defines the term “cancer” to mean “all malignant neoplasms, regardless of the tissue of origin, including malignant lymphoma and leukemia” and, before the 78th Legislative Session, required the reporting of incidences of cancer. (NRS 457.020, 457.230) Pursuant to Assembly Bill No. 42 of the 78th Legislative Session, the State Board of Health is: (1) authorized to require the reporting of incidences of neoplasms other than cancer, in addition to incidences of cancer, to the system for reporting such information established and maintained by the Chief Medical Officer; and (2) required to establish an administrative penalty to impose against any person who violates certain provisions which govern the abstracting of records of a health care facility relating to the neoplasms the Board requires to be reported.
    [Show full text]
  • Benign Brenner Tumor of Ovary - a Rare Case Report
    Nehal Tiwari, Hardik Gandhi. Benign Brenner tumor of ovary - A rare case report. IAIM, 2018; 5(10): 153-156. Case Report Benign Brenner tumor of ovary - A rare case report Nehal Tiwari1*, Hardik Gandhi1 1Resident Doctor, Pathology Department, SBKS MI & RC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India *Corresponding author email: [email protected] International Archives of Integrated Medicine, Vol. 5, Issue 10, October, 2018. Copy right © 2018, IAIM, All Rights Reserved. Available online at http://iaimjournal.com/ ISSN: 2394-0026 (P) ISSN: 2394-0034 (O) Received on: 12-09-2018 Accepted on: 17-09-2018 Source of support: Nil Conflict of interest: None declared. How to cite this article: Nehal Tiwari, Hardik Gandhi. Benign Brenner tumor of ovary - A rare case report. IAIM, 2018; 5(10): 153-156. Abstract Ovarian tumors are common forms of neoplasia in women and it accounts for about 30.0% of female genital cancers. Brenner tumors are subgroup of transitional cell tumors. Benign Brenner tumors are usually unilateral, small and solid. But in our case the tumor was very huge though showing all features of benign Brenner tumor on histopathological examination. For the diagnosis of benign Brenner tumor, radiological investigations are not a reliable tool. Therefore histopathological examination remains gold standard method for final diagnosis of this entity. This case report of large benign Brenner tumor is presented here because of its rarity. Key words Benign Brenner tumor, Rare, Ovarian tumors, Histopathological examination. Introduction association with serous and mucinous The ovarian lesion constitutes the major burden cystadenomas is up to 30% [1, 2]. USG and in gynecology practices due to anatomical computed tomography, both the techniques are location of the tumor and also due to the fact that less sensitive method for the diagnosis because these tumors may remain asymptomatic for a of its nonspecific appearance.
    [Show full text]
  • Gynecological Tumors in Mulibrey Nanism and Role for RING Finger Protein TRIM37 in the Pathogenesis of Ovarian Fibrothecomas
    Modern Pathology (2009) 22, 570–578 & 2009 USCAP, Inc All rights reserved 0893-3952/09 $32.00 www.modernpathology.org Gynecological tumors in Mulibrey nanism and role for RING finger protein TRIM37 in the pathogenesis of ovarian fibrothecomas Susann Karlberg1,2, Marita Lipsanen-Nyman2, Heini Lassus1, Jukka Kallija¨rvi3,4,5, Anna-Elina Lehesjoki3,4,5 and Ralf Butzow1,6 1Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland; 2Children’s Hospital, University of Helsinki, Helsinki, Finland; 3Folkha¨lsan Institute of Genetics, Helsinki, Finland; 4Department of Medical Genetics, University of Helsinki, Helsinki, Finland; 5Neuroscience Center, University of Helsinki, Helsinki, Finland and 6Department of Pathology, University of Helsinki, Helsinki, Finland Mulibrey nanism is an autosomal recessive growth disorder caused by mutations in the TRIM37 gene encoding a protein of unknown function. More than half of female patients with Mulibrey nanism develop benign mesenchymal tumors of ovarian sex cord–stromal origin. In this work, we characterize the gynecological tumors of female patients with Mulibrey nanism in detail. In addition to tumors of the fibrothecoma group, 18% (4/22) of the patients were observed with epithelial neoplasias, including 2 ovarian adenofibromas, 1 ovarian poorly differentiated adenocarcinoma and 1 endometrial adenocarcinoma. To investigate the possible involvement of TRIM37 alterations in the pathogenesis of sporadic fibrothecomas, we analyzed the TRIM37 cDNA for mutations and alternatively spliced transcripts and TRIM37 expression in fibrothecomas of women without Mulibrey nanism. No mutations in the open-reading frame of TRIM37 were detected. Two alternatively spliced variants were found, one lacking exon 23 and one exon 2.
    [Show full text]
  • Ovarian Sex Cord-Stromal Tumors
    Review Int J Gynecol Cancer: first published as 10.1136/ijgc-2020-002018 on 7 January 2021. Downloaded from Ovarian sex cord- stromal tumors: an update INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Original research Editorials Joint statement Society statement on clinical features, molecular changes, Meeting summary Review articles Consensus statement Clinical trial Case study Video articles Educational video lecture and management Images Pathology archives Corners of the world Commentary Letters ijgc.bmj.com Rehab Al Harbi,1 Iain A McNeish,2 Mona El- Bahrawy1,3 1Department of Metabolism, ABSTRACT cord tumors with annular tubules, arise from primi- Digestion, and Reproduction, 7 Sex cord stromal- tumors are rare tumors of the ovary that tive sex cord cells. Mixed sex cord- stromal tumors Imperial College London, include Sertoli–Leydig cell tumors and sex cord- London, UK include numerous tumor subtypes of variable histological 2Department of Surgery and features and biological behavior. Surgery is the main stromal tumors that have not otherwise been spec- 7 Cancer, Imperial College therapeutic modality for the management of these ified. London, London, UK tumors, while chemotherapy and hormonal therapy may Sex cord- stromal tumors may present with an 3 Department of Pathology, be used in some patients with progressive and recurrent adnexal mass, abdominal distention, and abdom- Faculty of Medicine, University tumors. Several studies investigated molecular changes inal pain.1 Unlike epithelial and germ cell tumors, of Alexandria, Alexandria, Egypt in the different tumor types. Understanding molecular some sex cord- stromal tumors have clinical signs of changes underlying the development and progression of hormone production, including menstrual changes, Correspondence to sex cord-stromal tumors provides valuable information 1 Professor Mona El-Bahra wy, for diagnostic and prognostic biomarkers and potential precocious puberty, hirsutism, and/or virilization.
    [Show full text]
  • Perspectives on Testicular Sex Cord-Stromal Tumors and Those Composed of Both Germ Cells
    ACCEPTED MANUSCRIPT Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms Lawrence M. Roth MD*1, Bingjian Lyu MD3, Liang Cheng MD*1,2 Department of Pathology and Laboratory Medicine1and Urology2, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Pathology3, Women’s Hospital, School of Medicine, Zhejiang University, 310003, China. Running Head: Perspectives on testicular sex cord-stromal tumors Keywords: Testis; Ovary; Sex cord-stromal tumors; Gonadoblastoma; Mixed germ cell- sex cord stromal tumor; Tumorigenesis. Address correspondence to: Lawrence M. Roth MD, Department of Pathology, Indiana University School of Medicine, Van Nuys Medical Science Building 128, 635 Barnhill Drive, Indianapolis, IN 46202, USA; [email protected] or Liang Cheng, MD, Department of Pathology, Indiana UniversityACCEPTED School of Medicine, Indianapolis, MANUSCRIPT IN 46202; [email protected] Disclosures: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. No conflict of interest exists. _________________________________________________________________________________ This is the author's manuscript of the article published in final edited form as: Roth, L. M., Lyu, B., & Cheng, L. (2017). Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms. Human Pathology. https://doi.org/10.1016/j.humpath.2017.04.009 ACCEPTED MANUSCRIPT Highlights - Sex cord-stromal tumors are the second most frequent category of testicular neoplasms. - They account for approximately 2-5% of testicular neoplasms in adults. - Both genetic and epigenetic factors account for their differences from ovarian SCSTs.
    [Show full text]
  • Section of Radiology President-J
    Sectional of the Medicine Vol. 48 page 1 Proceedings.1 h RoyalLy&SceyoSociey of 721 Section of Radiology President-J. F. BROMLEY, O.B.E., F.R.C.P. [January 21, 1955] DISCUSSION ON THE PATHOLOGY AND TREATMENT OF FUNCTIONING OVARIAN TIJMOURS AND OTHER UNUSUAL GROWTHS OF TIHE OVARY Dr. C. W. Taylor (Director of Pathology, The Birmingham and Midland Hospitals for Women, United Birmingham Hospitals): The Pathology and Histogenesis ofSpecial Ovarian Tumours The ovary is a common site of neoplasm. Certain primary tumours of the sex gland are associated with endocrine abnormalities-so-called "Functioning ovarian tumours". The effects are mainly of feminizing or masculinizing type. Tumours of similar histogenesis, though not associated with endocrine dysfunction, and tumours originally, but wrongly, thought to be of functional type, are usually discussed in the same context under the heading "Special and functioning ovarian tumours". Incidence.-From a ten-year study of cases of primary ovarian neoplasm at the Women's Hospital, Birmingham, the following figures were obtained (Taylor, 1950): Simple neoplasm .. 600 74-2% Malignant neoplasm .. 171 21-2% "Special" group .. 37 4 6% Total 808 The tumours classified under this "Special" group were: Granulosa cell tumour .. .. .. 18 Theca cell tumour .. .. .. 7 Arrhenoblastoma .. .. .. 3 Dysgerminoma .. .. .. .. 3 Brenner tumour .. .. .. .. 6 Total 37 The special group oftumours under consideration were not classified as simple or malignant at that time. The cases have been followed up and the findings will be referred to later by Dr. Blomfield. The theca cell and Brenner tumours are essentially benign. Histological examination of the others will not, in many cases, give an answer to the degree of clinical malignancy.
    [Show full text]
  • Supplemental Table 4. Expression of CX3CR1 in Specimens of Ovarian Cancer (Multiple Types)
    Supplemental Table 4. Expression of CX3CR1 in specimens of ovarian cancer (multiple types). Position Number Sex* Age* Organ* Pathology Diagnosis* Grade* Type* Intensity** Location Percentage*** Score**** 2 100 200 A1 1 F 38 Ovary Krukenberg tumor - Malignant cytoplasmic 1 80 80 A2 2 F 37 Ovary Krukenberg tumor - Malignant cytoplasmic 100 100 A3 3 F 30 Ovary Krukenberg tumor - Malignant 1 cytoplasmic 0 n/a 0 0 A4 4 F 35 Ovary Krukenberg tumor - Malignant 0 0 0 0 A5 5 F 54 Ovary Krukenberg tumor - Malignant 1.5 100 150 A6 6 F 54 Ovary Krukenberg tumor - Malignant cytoplasmic 3 100 300 A7 7 F 36 Ovary Krukenberg tumor - Malignant cytoplasmic 1 50 50 A8 8 F 49 Ovary Krukenberg tumor - Malignant cytoplasmic 3 90 270 A9 9 F 35 Ovary Krukenberg tumor - Malignant cytoplasmic 0 0 0 0 A10 10 F 36 Ovary Krukenberg tumor - Malignant 1 10 10 B1 11 F 65 Ovary Carcinosarcoma - Malignant cytoplasmic 2 70 140 B2 12 F 15 Ovary Yolk sac tumor - Malignant cytoplasmic 3 80 240 B3 13 F 27 Ovary Yolk sac tumor - Malignant cytoplasmic 2 80 160 B4 14 F 20 Ovary Yolk sac tumor - Malignant cytoplasmic 2.5 80 200 B5 15 F 14 Ovary Yolk sac tumor - Malignant cytoplasmic 0.5 20 10 B6 16 F 32 Ovary Yolk sac tumor - Malignant cytoplasmic 1.5 80 120 B7 17 F 22 Ovary Yolk sac tumor - Malignant cytoplasmic 1 10 10 B8 18 F 16 Ovary Yolk sac tumor - Malignant cytoplasmic 2 100 200 B9 19 F 15 Ovary Yolk sac tumor - Malignant cytoplasmic 3 100 300 B10 20 F 36 Ovary Dysgerminoma - Malignant cytoplasmic 1.5 70 105 C1 21 F 35 Ovary Dysgerminoma - Malignant cytoplasmic 1 80 80 C2
    [Show full text]
  • (NCCN Guidelines®) Ovarian Cancer
    ® NCCN NCCN Guidelines Index Ovarian Cancer TOC Discussion NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines® ) Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer Version 2.2013 NCCN.org NCCN Guidelines for Patients™ are available at www.nccn.com. Continue Version 2.2013, 06/13/13 © National Comprehensive Cancer Network, Inc. 2013, All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. ® NCCN NCCN Guidelines Version 2.2013 Panel Members NCCN Guidelines Index Ovarian Cancer TOC Ovarian Cancer Discussion * Robert J. Morgan, Jr., MD/Chair ‡ * Ardeshir Hakam, MD ¹ * Matthew A. Powell, MD W City of Hope Comprehensive Cancer Center Moffitt Cancer Center Siteman Cancer Center at Barnes- Jewish Hospital and Washington * Ronald D. Alvarez, MD W * Laura J. Havrilesky, MD W University School of Medicine University of Alabama at Birmingham Duke Cancer Institute Comprehensive Cancer Center Steven W. Remmenga, MD W Carolyn Johnston, MD W UNMC Eppley Cancer Center at * Deborah K. Armstrong, MD † University of Michigan The Nebraska Medical Center The Sidney Kimmel Comprehensive Comprehensive Cancer Center Cancer Center at Johns Hopkins Paul Sabbatini, MD †Þ * Shashikant Lele, MD W Memorial Sloan-Kettering Cancer Center Robert A. Burger, MD W Roswell Park Cancer Institute Fox Chase Cancer Center Joseph T. Santoso, MD W Lainie Martin, MD † St. Jude Children’s Research Hospital/ Lee-may Chen, MD W Fox Chase Cancer Center University of Tennessee Cancer Institute UCSF Helen Diller Family Comprehensive Cancer Center * Ursula A. Matulonis, MD † *Julian C. Schink, MD W Dana-Farber/Brigham and Women’s Robert H.
    [Show full text]
  • A Case Report of Ovarian Fibrothecoma in a Premenopausal Women with Recurrent Menorrhagia
    Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2020 Jul 20; 8(C):101-105. https://doi.org/10.3889/oamjms.2020.4176 eISSN: 1857-9655 Category: C - Case Reports Section: Case Reports in Gynecology and Obstetrics A Case Report of Ovarian Fibrothecoma in a Premenopausal Women with Recurrent Menorrhagia Meral Rexhepi1,2*, Elizabeta Trajkovska3, Hysni Ismaili2, Majlinda Azemi4 1Department of Gynecology and Obstetrics, Clinical Hospital, Tetovo, Republic of Macedonia; 2Faculty of Medical Sciences, University of Tetovo, Republic of Macedonia; 3Department of Pathology, Clinical Hospital, Tetovo, Republic of Macedonia; 4University Clinic of Gynaecology and Obstetrics, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia Abstract Edited by: Igor Spiroski BACKGROUND: Ovarian fibrothecoma is a rare, benign, sex cord-stromal neoplasm, with a typically unilateral Citation: Rexhepi M, Trajkovska E, Ismaili H, Azemi M. A Case Report of Ovarian Fibrothecoma in a location in the ovary, characterized by mixed features of both fibroma and thecoma. Ovarian fibrothecoma is Premenopausal Women with Recurrent Menorrhagia. uncommon tumor of gonadal stromal cell origin accounting for 3-4% of all ovarian tumours. Open Access Maced J Med Sci. 2020 Jul 20; 8(C):101-105. https://doi.org/10.3889/oamjms.2020.4176 CASE PRESENTATION: We presented a rare case of a 46-year-old patient with recurrent menorrhagia in the Keywords: Ovarian granulosa cell tumor; Fibrothecoma; Endometrial hyperplasia past two years with no previous medical, surgical or gynecological history. She underwent two times curettage *Correspondence: Meral Rexhepi, Department procedures. At the admission to hospital ultrasonography showed a homogenous solid right ovarian mass of size of Gynecology and Obstetrics, Clinical Hospital, 2.5 cm x 3.5 cm.
    [Show full text]