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Blockage of Neddylation Modification Stimulates Tumor Sphere Formation
Blockage of neddylation modification stimulates tumor PNAS PLUS sphere formation in vitro and stem cell differentiation and wound healing in vivo Xiaochen Zhoua,b,1, Mingjia Tanb,1, Mukesh K. Nyatib, Yongchao Zhaoc,d, Gongxian Wanga,2, and Yi Sunb,c,e,2 aDepartment of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China; bDivision of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109; cInstitute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; dKey Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; and eCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China Edited by Vishva M. Dixit, Genentech, San Francisco, CA, and approved March 10, 2016 (received for review November 13, 2015) MLN4924, also known as pevonedistat, is the first-in-class inhibitor acting alone or in combination with current chemotherapy of NEDD8-activating enzyme, which blocks the entire neddylation and/or radiation (6, 11). One of the seven clinical trials of MLN4924 modification of proteins. Previous preclinical studies and current (NCT00911066) was published recently, concluding a modest effect clinical trials have been exclusively focused on its anticancer property. of MLN4924 against acute myeloid leukemia (AML) (12). Unexpectedly, we show here, to our knowledge for the first time, To further elucidate the role of blocking neddylation in cancer that MLN4924, when applied at nanomolar concentrations, signif- treatment, we thought to study the effect of MLN4924 on cancer icantly stimulates in vitro tumor sphere formation and in vivo stem cells (CSCs) or tumor-initiating cells (TICs), a small group tumorigenesis and differentiation of human cancer cells and mouse of tumor cells with stem cell properties that have been claimed to embryonic stem cells. -
Medicare 2019 Part C & D Star Ratings Cut Point Trends
Trends in Part C & D Star Rating Measure Cut Points Updated – 12/19/2018 (Last Updated 12/19/2018) Page 1 Document Change Log Previous Revision Version Description of Change Date - Final release of the 2019 Star Ratings Cut Point Trend document 12/19/2018 (Last Updated 12/19/2018) Page i Table of Contents DOCUMENT CHANGE LOG .............................................................................................................................. I TABLE OF CONTENTS .................................................................................................................................... II INTRODUCTION ............................................................................................................................................... 1 PART C MEASURES ........................................................................................................................................ 2 Measure: C01 - Breast Cancer Screening ........................................................................................................................ 2 Measure: C02 - Colorectal Cancer Screening .................................................................................................................. 3 Measure: C03 - Annual Flu Vaccine .................................................................................................................................. 4 Measure: C04 - Improving or Maintaining Physical Health ........................................................................................... -
Thermo-Responsive Poly(N-Isopropylacrylamide)- Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing
Article Thermo-Responsive Poly(N-Isopropylacrylamide)- Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing Katarzyna Zubik 1, Pratyawadee Singhsa 1,2, Yinan Wang 1, Hathaikarn Manuspiya 2 and Ravin Narain 1,* 1 Department of Chemical and Materials Engineering, Donadeo Innovation Centre in Engineering, 116 Street and 85 Avenue, Edmonton, AB T6G 2G6, Canada; [email protected] (K.Z.); [email protected] (P.S.); [email protected] (Y.W.) 2 The Petroleum and Petrochemical College, Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Soi Chulalongkorn 12, Pathumwan, Bangkok 10330, Thailand; [email protected] * Correspondence: [email protected]; Tel.: +1-780-492-1736 Academic Editor: Shiyong Liu Received: 29 January 2017; Accepted: 21 March 2017; Published: 24 March 2017 Abstract: Thermo-responsive hydrogels containing poly(N-isopropylacrylamide) (PNIPAAm), reinforced both with covalent and non-covalent interactions with cellulose nanocrystals (CNC), were synthesized via free-radical polymerization in the absence of any additional cross-linkers. The properties of PNIPAAm-CNC hybrid hydrogels were dependent on the amounts of incorporated CNC. The thermal stability of the hydrogels decreased with increasing CNC content. The rheological measurement indicated that the elastic and viscous moduli of hydrogels increased with the higher amounts of CNC addition, representing stronger mechanical properties of the hydrogels. Moreover, the hydrogel injection also supported the hypothesis that CNC reinforced the hydrogels; the increased CNC content exhibited higher structural integrity upon injection. The PNIPAAm- CNC hybrid hydrogels exhibited clear thermo-responsive behavior; the volume phase transition temperature (VPTT) was in the range of 36 to 39 °C, which is close to normal human body temperature. -
High-Dose Chemotherapy Less Frequent Catheter Dressing Changes
Bone Marrow Transplantation (2002) 29, 653–658 2002 Nature Publishing Group All rights reserved 0268–3369/02 $25.00 www.nature.com/bmt High-dose chemotherapy Less frequent catheter dressing changes decrease local cutaneous toxicity of high-dose chemotherapy in children, without increasing the rate of catheter-related infections: results of a randomised trial E Benhamou1, E Fessard2, C Com-Nougue´1,3, PS Beaussier2, G Nitenberg4, C Tancre`de5, S Dodeman2 and O Hartmann2 1Department of Biostatistics and Epidemiology, Institut Gustave Roussy, Villejuif, France; 2Department of Pediatrics, Institut Gustave Roussy, Villejuif, France; 3Pierre et Marie Curie University, Paris, France; 4Intensive Care Unit, Institut Gustave Roussy, Villejuif, France; and 5Department of Microbiology, Institut Gustave Roussy, Villejuif, France Summary: In our hospital, patients treated with high-dose chemo/radiotherapy (HDC) regimens followed by bone Cutaneous lesions caused by catheter dressing changes marrow transplantation (BMT) are fitted with a central can be serious and generate local pain in children venous catheter which is usually inserted a few days before undergoing high-dose chemotherapy followed by bone hospitalisation in the transplantation unit. Usually, central marrow transplantation. One hundred and thirteen venous catheter dressings are changed, empirically, every children entered a randomised trial to compare two 3 or 4 days,1,2 whatever the state of the dressing and mostly catheter dressing change frequencies (15 days vs 4 days). because less frequent changes are suspected of promoting Skin toxicity was classified according to the following local infections likely to give rise to bacteraemia in granul- scale: grade 0: healthy skin, to grade 4: severe skin tox- ocytopenic patients. -
Local Anesthetics in Cosmetic Dermatology
COSMETIC DERMATOLOGY Local Anesthetics in Cosmetic Dermatology Peter W. Hashim, MD, MHS; John K. Nia, MD; Mark Taliercio, BS; Gary Goldenberg, MD PRACTICE POINTS • The proper delivery of local anesthesia is integral to successful cosmetic interventions. • Regional nerve blocks can provide effective analgesia while reducing the number of injections and preserving the architecture of the cosmetic field. copy Local anesthetics play an important role in cos- LOCAL ANESTHETICS metic dermatology. Techniques using topical and The sensation of pain is carried to the central ner- regional anesthesia provide numerous pain man- vousnot system by unmyelinated C nerve fibers. Local agement options for laser and injection treatments. anesthetics (LAs) act by blocking fast voltage-gated In this article, we review strategies to maximize sodium channels in the cell membrane of the nerve, patient comfort during cosmetic interventions. thereby inhibiting downstream propagation of an Cutis. 2017;99:393-397.Doaction potential and the transmission of painful stimuli.1 The chemical structure of LAs is funda- mental to their mechanism of action and metabo- ocal anesthesia is a central component of suc- lism. Local anesthetics contain a lipophilic aromatic cessful interventions in cosmetic dermatol- group, an intermediate chain, and a hydrophilic Logy. The number of anesthetic medications amine group. Broadly, agents are classified as amides and administration techniques has grown in recent or esters depending on the chemical group attached years as outpatient cosmetic procedures continue to the intermediate chain.2 Amides (eg, lidocaine, to expand. Pain is a commonCUTIS barrier to cosmetic bupivacaine, articaine, mepivacaine, prilocaine, procedures, and alleviating the fear of painful inter- levobupivacaine) are metabolized by the hepatic sys- ventions is critical to patient satisfaction and future tem; esters (eg, procaine, proparacaine, benzocaine, visits. -
EMA/CVMP/508559/2019 Committee for Medicinal Products for Veterinary Use
28 August 2020 EMA/CVMP/508559/2019 Committee for Medicinal Products for Veterinary Use Advice on implementing measures under Article 106 (6) of Regulation (EU) 2019/6 on veterinary medicinal products – scientific problem analysis and recommendations to ensure a safe and efficient administration of oral veterinary medicinal products via routes other than medicated feed Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 An agency of the European Union © European Medicines Agency, 2020. Reproduction is authorised provided the source is acknowledged. Introduction On 1 July 2019 the European Commission requested the European Medicines Agency to provide a scientific problem analysis and recommendations to ensure the safe and efficient oral administration of veterinary medicinal products via routes other than medicated feed, by taking into account: - the effective and safe use of veterinary medicinal products authorised and prescribed for oral administration via routes other than medicated feed, such as mixing of water for drinking with a veterinary medicinal product, mixing of a veterinary medicinal product into the ordinary feed by the farmer or by use of top-dressing of the feed offered to the animal in a feeding device with a veterinary medicinal product (solid or as an emulsion); this issue should address the borderline between medication with medicated feed -
A Field Guide to Common Wildlife Diseases and Parasites in the Northwest Territories
A Field Guide to Common Wildlife Diseases and Parasites in the Northwest Territories 6TH EDITION (MARCH 2017) Introduction Although most wild animals in the NWT are healthy, diseases and parasites can occur in any wildlife population. Some of these diseases can infect people or domestic animals. It is important to regularly monitor and assess diseases in wildlife populations so we can take steps to reduce their impact on healthy animals and people. • recognize sickness in an animal before they shoot; •The identify information a disease in this or field parasite guide in should an animal help theyhunters have to: killed; • know how to protect themselves from infection; and • help wildlife agencies monitor wildlife disease and parasites. The diseases in this booklet are grouped according to where they are most often seen in the body of the Generalanimal: skin, precautions: head, liver, lungs, muscle, and general. Hunters should look for signs of sickness in animals • poor condition (weak, sluggish, thin or lame); •before swellings they shoot, or lumps, such hair as: loss, blood or discharges from the nose or mouth; or • abnormal behaviour (loss of fear of people, aggressiveness). If you shoot a sick animal: • Do not cut into diseased parts. • Wash your hands, knives and clothes in hot, soapy animal, and disinfect with a weak bleach solution. water after you finish cutting up and skinning the 2 • If meat from an infected animal can be eaten, cook meat thoroughly until it is no longer pink and juice from the meat is clear. • Do not feed parts of infected animals to dogs. -
Instructions After Anorectal Surgery
Instructions After Anorectal Surgery You are scheduled for ambulatory or same day admission surgery. Your colorectal attending surgeon, resident staff and the anesthesia staff will meet you in the preanesthesia area to answer any questions that you may have before your surgery. Your surgeon will talk with your family members in the waiting area after the procedure by telephone or in person. Any special instructions will be given to you or your family member at that time. If general or regional anesthesia is used, you will be monitored in the recovery room for 1-2 hours after your surgery. A responsible adult must accompany you home. You should not drive or operate machinery for the remainder of the day. You will be given any prescriptions or dressings needed for discharge. Wound Care You should remove your dressings on the morning after your procedure. If the dressing become soiled or soaked, you may change them on the evening of the procedures. Any packing within the anus or wounds should be removed gently from the anus before or during the first bath. It may be easier to remove the gauze after you get into the water once it is wet. Warm tub or sitz baths should be taken 3-4 times per day initially, especially after each bowel movement. After the first week you may decrease this to 2 times per day. You do not need to add anything to the water (no Epson salts, etc). You may notice slight ooze or bleeding for several days, usually with bowel movements. You do not need to apply or insert any packing after your first bath but you must place gauze pads to absorb any drainage and protect your undergarments. -
Collagen Dressings in Chronic Wound Healing
Collagen Dressings in Chronic Wound Healing © 2015 Jones Foster Deal Advertising & Public Relations, Inc. All Rights Reserved Collagen Dressings in Chronic Wound Healing Collagen Dressings in Chronic Wound Healing Introduction and Background .................................................................................................... 1 Ideal Dressing ................................................................................................................... 6 Exudate Management ....................................................................................................... 7 Moisture and Depth .......................................................................................................... 7 Wound Care Science ................................................................................................................. 9 Phase I Hemostasis ..................................................................................................... 10 Phase II Inflammation.....................................................................................................11 Phase III Proliferation ..................................................................................................... 14 Phase IV Remodeling ..................................................................................................... 15 Collagen................................................................................................................................... 16 Types of Collagen .......................................................................................................... -
Disconnecting Chemotherapy in the Patient's Home
Disconnecting Chemotherapy in the Patient’s Home Maria Hagan RN, BSN, CRNI 1-800-862- 2731 Introduction • HomeMed has partnered with U of M’s Comprehensive Cancer Center for many years & provided safe home chemotherapy for thousands of cancer patients. • HomeMed’s home infusion nurses have historically provided the home disconnections – However, the program is growing and we are now subcontracting nursing agencies to provide this service. – Welcome aboard! HomeMed • Office hours M-F 8a-5:30p – 1-800-862-2731-A receptionist will direct your call to the appropriate person. Just state your patient’s name and reason for call. – Nurses/pharmacists are on call and available for you 24/7 • In home nurses experienced in chemotherapy home disconnections. • Some reasons to call HomeMed: – Any question or concern about a HomeMed patient or their care. – Order clarification – Need more visits authorized for non-bundled patients – Supply management – Lab drop off site (if it is not a M lab) *lab work is not usually ordered for home chemotherapy patients because they get it done in the cancer center *If your patient is unable to tell you the disconnection time • The patient/cg is instructed on their disconnection time & it is written on their Connection& Disconnection Documentation Sheet HomeMed’s Website for Health Professionals • Helpful Resources – Nursing Policy and Procedures – Home Chemotherapy Manuel – Safe chemotherapy disposal – M lab drop off sites – Other • Link with patient resources • http://www.med.umich.edu/homecare/homemed/prof/index.htm -
New Approach to Antifungal Activity of Fluconazole Incorporated
International Journal of Molecular Sciences Article New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-L-Galacto-β-D -Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation Justyna Rewak-Soroczynska 1 , Paulina Sobierajska 1 , Sara Targonska 1 , Agata Piecuch 2 , Lukasz Grosman 1, Jaroslaw Rachuna 3, Slawomir Wasik 4 , Michal Arabski 3 , Rafal Ogorek 2 and Rafal J. Wiglusz 1,* 1 Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland; [email protected] (J.R.-S.); [email protected] (P.S.); [email protected] (S.T.); [email protected] (L.G.) 2 Department of Mycology and Genetics, University of Wroclaw, Przybyszewskiego 63, 51-148 Wroclaw, Poland; [email protected] (A.P.); [email protected] (R.O.) 3 Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland; [email protected] (J.R.); [email protected] (M.A.) 4 Institute of Physics, Jan Kochanowski University, Swietokrzyska 15, 25-406 Kielce, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-(071)-395-4159 Citation: Rewak-Soroczynska, J.; Sobierajska, P.; Targonska, S.; Piecuch, Abstract: New fluconazole-loaded, 6-Anhydro-α-L-Galacto-β-D-Galactan hydrogels incorporated A.; Grosman, L.; Rachuna, J.; Wasik, with nanohydroxyapatite were prepared and their physicochemical features (XRD, X-ray Diffrac- S.; Arabski, M.; Ogorek, R.; Wiglusz, tion; SEM-EDS, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy; ATR-FTIR, R.J. New Approach to Antifungal Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy), fluconazole release profiles Activity of Fluconazole Incorporated and enzymatic degradation were determined. -
Wound Care Product Categories
Wound Product Categories Esther Hattler, BS,RN,WCC Objectives The attendee will be able to list 3 different categories of wound products Some Basics Application of moist wound healing by adding moisture to dry wounds Absorbent dressings to absorb wound exudate Debridement A dry cell is a dead cell Moist wound healing Moist wound healing was started by Dr. George Winter in about 1962 when he found that a moist wound healed twice as fast as a dry wound. With the concept of moist wound healing the purpose of products has expanded from hemostasis, prevention of infection and wound protection. Wet-To-Dry and Wet To Moist Dressings Wet to dry became the gold standard of wound care and is still often used and sometimes appropriate. The more advanced dressings cost more OR do they? Wet to Dry - Wet to Moist Consider the cost of the dressing Cost of nursing labor Indirect costs, gloves, biohazard waste Cost of duration, how long it takes to heal Wet to dry needs to be done at least twice a day More advanced product can be left on longer, some up to 5 to 7 days More on “wet to dry” dressings When a wound is open to air, it can take up to 4 hours for it to warm back up for healing One study showed that bacteria were capable of penetrating 64 layers of gauze Another study showed that a semiocclusive dressing total cost was $15.90 while wet to dry total cost was $25.31 Moist wound healing Facilitation of debridement Reducing pain Diminished scarring This all has led to Over 2000 products on the market! Hydrocolloids Original