biomolecules Review The Bigger Picture: Why Oral Mucosa Heals Better Than Skin Maaike Waasdorp 1,* , Bastiaan P. Krom 2 , Floris J. Bikker 3 , Paul P. M. van Zuijlen 4,5,6, Frank B. Niessen 5 and Susan Gibbs 1,7 1 Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands;
[email protected] 2 Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands;
[email protected] 3 Department of Oral Biochemistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands;
[email protected] 4 Burn Centre, and Department of Plastic, Reconstructive and Hand Surgery, Red Cross Hospital, Vondellaan 13, 1942 LE Beverwijk, The Netherlands;
[email protected] 5 Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands;
[email protected] 6 Department of Pediatric Surgery, Amsterdam University Medical Centers, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands 7 Department of Oral Cell Biology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands * Correspondence:
[email protected] Abstract: Wound healing is an essential process to restore tissue integrity after trauma. Large Citation: Waasdorp, M.; Krom, B.P.; skin wounds such as burns often heal with hypertrophic scarring and contractures, resulting in Bikker, F.J.; van Zuijlen, P.P.M.; disfigurements and reduced joint mobility.