Zelena et al. Zelena D, Stocker B, Barna I, Tóth ZE, Makara GB Vasopressin deficiency diminishes acute and long-term consequences of maternal deprivation in male rat pups, Psychoneuronedocrinology 2015 Jan;51:378-91. doi: 10.1016/j.psyneuen.2014.10.018. Epub 2014 Oct 24 Manuscript as accepted Vasopressin deficiency diminishes acute and long-term consequences of maternal deprivation in male rat pups Dóra Zelenaa, Berhard Stockera, István Barnaa, Zsuzsanna E. Tóthb, Gábor B.Makaraa aInstitute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary bDepartment of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary Corresponding author: Dóra Zelena 1083 Budapest Szigony 43. Hungary Tel: +36-1-2109400/290 Fax.: +36-1-2109951 e-mail:
[email protected] Short title: Long term consequences of maternal deprivation in Brattleboro rats 1 You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Zelena et al. Abstract Early life events have special importance in the development as postnatal environmental alterations may permanently affect the lifetime vulnerability to diseases. For the interpretation of the long-term consequences it is important to understand the immediate effects. As the role of vasopressin in hypothalamic-pituitary-adrenal axis regulation as well as in affective disorders seem to be important we addressed the question whether the congenital lack of vasopressin will modify the stress reactivity of the pups and will influence the later consequences of single 24h maternal deprivation (MD) on both stress-reactivity and stress-related behavioral changes. Vasopressin-producing (di/+) and deficient (di/di) Brattleboro rat were used.