Causality and Graphical Models in Time Series Analysis
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The Practice of Causal Inference in Cancer Epidemiology
Vol. 5. 303-31 1, April 1996 Cancer Epidemiology, Biomarkers & Prevention 303 Review The Practice of Causal Inference in Cancer Epidemiology Douglas L. Weedt and Lester S. Gorelic causes lung cancer (3) and to guide causal inference for occu- Preventive Oncology Branch ID. L. W.l and Comprehensive Minority pational and environmental diseases (4). From 1965 to 1995, Biomedical Program IL. S. 0.1. National Cancer Institute, Bethesda, Maryland many associations have been examined in terms of the central 20892 questions of causal inference. Causal inference is often practiced in review articles and editorials. There, epidemiologists (and others) summarize evi- Abstract dence and consider the issues of causality and public health Causal inference is an important link between the recommendations for specific exposure-cancer associations. practice of cancer epidemiology and effective cancer The purpose of this paper is to take a first step toward system- prevention. Although many papers and epidemiology atically reviewing the practice of causal inference in cancer textbooks have vigorously debated theoretical issues in epidemiology. Techniques used to assess causation and to make causal inference, almost no attention has been paid to the public health recommendations are summarized for two asso- issue of how causal inference is practiced. In this paper, ciations: alcohol and breast cancer, and vasectomy and prostate we review two series of review papers published between cancer. The alcohol and breast cancer association is timely, 1985 and 1994 to find answers to the following questions: controversial, and in the public eye (5). It involves a common which studies and prior review papers were cited, which exposure and a common cancer and has a large body of em- causal criteria were used, and what causal conclusions pirical evidence; over 50 studies and over a dozen reviews have and public health recommendations ensued. -
Statistics and Causal Inference (With Discussion)
Applied Statistics Lecture Notes Kosuke Imai Department of Politics Princeton University February 2, 2008 Making statistical inferences means to learn about what you do not observe, which is called parameters, from what you do observe, which is called data. We learn the basic principles of statistical inference from a perspective of causal inference, which is a popular goal of political science research. Namely, we study statistics by learning how to make causal inferences with statistical methods. 1 Statistical Framework of Causal Inference What do we exactly mean when we say “An event A causes another event B”? Whether explicitly or implicitly, this question is asked and answered all the time in political science research. The most commonly used statistical framework of causality is based on the notion of counterfactuals (see Holland, 1986). That is, we ask the question “What would have happened if an event A were absent (or existent)?” The following example illustrates the fact that some causal questions are more difficult to answer than others. Example 1 (Counterfactual and Causality) Interpret each of the following statements as a causal statement. 1. A politician voted for the education bill because she is a democrat. 2. A politician voted for the education bill because she is liberal. 3. A politician voted for the education bill because she is a woman. In this framework, therefore, the fundamental problem of causal inference is that the coun- terfactual outcomes cannot be observed, and yet any causal inference requires both factual and counterfactual outcomes. This idea is formalized below using the potential outcomes notation. -
Pioneers in Optics: Christiaan Huygens
Downloaded from Microscopy Pioneers https://www.cambridge.org/core Pioneers in Optics: Christiaan Huygens Eric Clark From the website Molecular Expressions created by the late Michael Davidson and now maintained by Eric Clark, National Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32306 . IP address: [email protected] 170.106.33.22 Christiaan Huygens reliability and accuracy. The first watch using this principle (1629–1695) was finished in 1675, whereupon it was promptly presented , on Christiaan Huygens was a to his sponsor, King Louis XIV. 29 Sep 2021 at 16:11:10 brilliant Dutch mathematician, In 1681, Huygens returned to Holland where he began physicist, and astronomer who lived to construct optical lenses with extremely large focal lengths, during the seventeenth century, a which were eventually presented to the Royal Society of period sometimes referred to as the London, where they remain today. Continuing along this line Scientific Revolution. Huygens, a of work, Huygens perfected his skills in lens grinding and highly gifted theoretical and experi- subsequently invented the achromatic eyepiece that bears his , subject to the Cambridge Core terms of use, available at mental scientist, is best known name and is still in widespread use today. for his work on the theories of Huygens left Holland in 1689, and ventured to London centrifugal force, the wave theory of where he became acquainted with Sir Isaac Newton and began light, and the pendulum clock. to study Newton’s theories on classical physics. Although it At an early age, Huygens began seems Huygens was duly impressed with Newton’s work, he work in advanced mathematics was still very skeptical about any theory that did not explain by attempting to disprove several theories established by gravitation by mechanical means. -
Bayesian Causal Inference
Bayesian Causal Inference Maximilian Kurthen Master’s Thesis Max Planck Institute for Astrophysics Within the Elite Master Program Theoretical and Mathematical Physics Ludwig Maximilian University of Munich Technical University of Munich Supervisor: PD Dr. Torsten Enßlin Munich, September 12, 2018 Abstract In this thesis we address the problem of two-variable causal inference. This task refers to inferring an existing causal relation between two random variables (i.e. X → Y or Y → X ) from purely observational data. We begin by outlining a few basic definitions in the context of causal discovery, following the widely used do-Calculus [Pea00]. We continue by briefly reviewing a number of state-of-the-art methods, including very recent ones such as CGNN [Gou+17] and KCDC [MST18]. The main contribution is the introduction of a novel inference model where we assume a Bayesian hierarchical model, pursuing the strategy of Bayesian model selection. In our model the distribution of the cause variable is given by a Poisson lognormal distribution, which allows to explicitly regard discretization effects. We assume Fourier diagonal covariance operators, where the values on the diagonal are given by power spectra. In the most shallow model these power spectra and the noise variance are fixed hyperparameters. In a deeper inference model we replace the noise variance as a given prior by expanding the inference over the noise variance itself, assuming only a smooth spatial structure of the noise variance. Finally, we make a similar expansion for the power spectra, replacing fixed power spectra as hyperparameters by an inference over those, where again smoothness enforcing priors are assumed. -
Articles Causal Inference in Civil Rights Litigation
VOLUME 122 DECEMBER 2008 NUMBER 2 © 2008 by The Harvard Law Review Association ARTICLES CAUSAL INFERENCE IN CIVIL RIGHTS LITIGATION D. James Greiner TABLE OF CONTENTS I. REGRESSION’S DIFFICULTIES AND THE ABSENCE OF A CAUSAL INFERENCE FRAMEWORK ...................................................540 A. What Is Regression? .........................................................................................................540 B. Problems with Regression: Bias, Ill-Posed Questions, and Specification Issues .....543 1. Bias of the Analyst......................................................................................................544 2. Ill-Posed Questions......................................................................................................544 3. Nature of the Model ...................................................................................................545 4. One Regression, or Two?............................................................................................555 C. The Fundamental Problem: Absence of a Causal Framework ....................................556 II. POTENTIAL OUTCOMES: DEFINING CAUSAL EFFECTS AND BEYOND .................557 A. Primitive Concepts: Treatment, Units, and the Fundamental Problem.....................558 B. Additional Units and the Non-Interference Assumption.............................................560 C. Donating Values: Filling in the Missing Counterfactuals ...........................................562 D. Randomization: Balance in Background Variables ......................................................563 -
A New Earth Study Guide.Pdf
A New Earth Study Guide Week 1 The consciousness that says ‘I am’ is not the consciousness that thinks. —Jean-Paul Sartre Affi rmation: "Through the guidance and wisdom of Spirit, I am being transformed by the renewing of my mind. All obstacles and emotions are stepping stones to the realization and appreciation of my sacred humanness." Study Questions – A New Earth (Review chapters 1 & 2, pp 1-58) Chapter 1: The Flowering of Human Consciousness Refl ect: Eckhart Tolle uses the image of the fi rst fl ower to begin his discussion of the transformation of consciousness. In your transformation, is this symbolism important to you? Describe. The two core insights of early religion are: 1) the normal state of human consciousness is dysfunctional (the Hindu call it maya – the veil of delusion) and 2) the opportunity for transformation is also in human consciousness (the Hindu call this enlightenment) (p. 8-9). What in your recent experience points to each of these insights? “To recognize one’s own insanity is, of course, the arising of sanity, the beginning of healing and transcendence” (p. 14). To what extent and in what circumstances (that you’re willing to discuss) does this statement apply to you? Religion is derived from the Latin word religare, meaning “to bind.” What, in your religious experience, have you been bound to? Stretching your imagination a bit, what could the word have pointed to in its original context? Spirit is derived from the Latin word spiritus, breath, and spirare, to blow. Aside from the allusion to hot air, how does this word pertain to your transformation? Do you consider yourself to be “spiritual” or “religious”? What examples of practices or beliefs can you give to illustrate? How does this passage from Revelation 21:1-4 relate to your transformation? Tease out as much of the symbolism as you can. -
Global History and the Present Time
Global History and the Present Time Wolf Schäfer There are three times: a present time of past things; a present time of present things; and a present time of future things. St. Augustine1 It makes sense to think that the present time is the container of past, present, and future things. Of course, the three branches of the present time are heavily inter- twined. Let me illustrate this with the following story. A few journalists, their minds wrapped around present things, report the clash of some politicians who are taking opposite sides in a struggle about future things. The politicians argue from histori- cal precedent, which was provided by historians. The historians have written about past things in a number of different ways. This gets out into the evening news and thus into the minds of people who are now beginning to discuss past, present, and future things. The people’s discussion returns as feedback to the journalists, politi- cians, and historians, which starts the next round and adds more twists to the en- tangled branches of the present time. I conclude that our (hi)story has no real exit doors into “the past” or “the future” but a great many mirror windows in each hu- man mind reflecting spectra of actual pasts and potential futures, all imagined in the present time. The complexity of the present (any given present) is such that no- body can hope to set the historical present straight for everybody. Yet this does not mean that a scientific exploration of history is impossible. History has a proven and robust scientific method. -
Outlook Calendar and Time Management Tips
Outlook Calendar and Time Management Tips: Setting up and maintaining your Outlook calendar is an easy way to manage your busy schedule and daily activities. Outlook calendar is great because you can sync it to your mobile and other devices, which you can access no matter where you are. You can also set up reminders to appear on your phone to remind you when and where you need to be. When setting up your Outlook calendar initially, it is recommented to do so on a computer so you can have access to more options (like color-coding, repeating appointments, etc.). You will start with a blank template, as shown below: Start with the basics – put in your formation, and your meal breaks (remember, your brain and body need fuel!). Then you can start putting in your class schedule with the class name, times and location. Be sure when scheduling events that you select the “Recurrence” option and specify what days you want the event to repeat, so it is on your calendar every week! After inputting your class schedule, take the opportunity to schedule your homework and study schedule into your week! Be sure to use the study time ratio: For each 1 unit, you should be studying 2-3 hours per week. (That means for a 3 unit class, you should be allocating 6-9 hours of study time per week. For a more difficult class, such as Calc I, start with 3 hours per unit. Study time includes homework, tutoring, paper writing and subject review.) If you’d like to add more to your calendar, feel free! Adding activites you like to do routinely, like working out, or Friday dinner with friends, helps motivate you to complete other tasks in the day so that you are free to go to these activities. -
Causation and Causal Inference in Epidemiology
PUBLIC HEALTH MAnERS Causation and Causal Inference in Epidemiology Kenneth J. Rothman. DrPH. Sander Greenland. MA, MS, DrPH. C Stat fixed. In other words, a cause of a disease Concepts of cause and causal inference are largely self-taught from early learn- ing experiences. A model of causation that describes causes in terms of suffi- event is an event, condition, or characteristic cient causes and their component causes illuminates important principles such that preceded the disease event and without as multicausality, the dependence of the strength of component causes on the which the disease event either would not prevalence of complementary component causes, and interaction between com- have occun-ed at all or would not have oc- ponent causes. curred until some later time. Under this defi- Philosophers agree that causal propositions cannot be proved, and find flaws or nition it may be that no specific event, condi- practical limitations in all philosophies of causal inference. Hence, the role of logic, tion, or characteristic is sufiicient by itself to belief, and observation in evaluating causal propositions is not settled. Causal produce disease. This is not a definition, then, inference in epidemiology is better viewed as an exercise in measurement of an of a complete causal mechanism, but only a effect rather than as a criterion-guided process for deciding whether an effect is pres- component of it. A "sufficient cause," which ent or not. (4m JPub//cHea/f/i. 2005;95:S144-S150. doi:10.2105/AJPH.2004.059204) means a complete causal mechanism, can be defined as a set of minimal conditions and What do we mean by causation? Even among eral. -
The Best Time to Market Sheep and Goats by Anthony Carver, Extension Agent – Grainger County UT Extension
The Best Time to Market Sheep and Goats By Anthony Carver, Extension Agent – Grainger County UT Extension Any producer of any product always wants the best price they can get. Sheep and goat producers are the exact same way. To really understand the demand and supply economics of sheep and goats, one must first understand the large groups purchasing them. The main purchasers for sheep and goats are ethnic groups. The purchasers recognize different holidays and feast days than most Tennessee producers. This is the most important factor to understand in marketing sheep and goats. Just like all holidays, the demand for certain foods go up. An example would be Thanksgiving. Thanksgiving usually means having a turkey on the table. The same can be said for the Eid-al-Fitr or Eid-al-Adha only with goat and sheep. It’s not only important to know the different holidays that the ethnic groups recognize, but to understand when they are held. Now, it gets complicated. Most of the holidays are not on our calendar year, but follow the lunar calendar. This means the holiday is not the same days year after year. It will be critical to look up the dates each year for the ethnic holidays. Here are some search words and websites to help: Interfaith Calendar - http://www.interfaithcalendar.org/index.htm Cornell University Sheep and Goat Marketing - http://sheepgoatmarketing.info/calendar.php North Carolina State University MEAT GOAT NOTES - https://rowan.ces.ncsu.edu/wp-content/uploads/2014/04/Ethnic-Holidays-2014-2018.pdf?fwd=no Some sheep and goat producers have heard of Ramadan (a Muslim and Somalis holiday). -
Experiments & Observational Studies: Causal Inference in Statistics
Experiments & Observational Studies: Causal Inference in Statistics Paul R. Rosenbaum Department of Statistics University of Pennsylvania Philadelphia, PA 19104-6340 1 My Concept of a ‘Tutorial’ In the computer era, we often receive compressed • files, .zip. Minimize redundancy, minimize storage, at the expense of intelligibility. Sometimes scientific journals seemed to have been • compressed. Tutorial goal is: ‘uncompress’. Make it possible to • read a current article or use current software without going back to dozens of earlier articles. 2 A Causal Question At age 45, Ms. Smith is diagnosed with stage II • breast cancer. Her oncologist discusses with her two possible treat- • ments: (i) lumpectomy alone, or (ii) lumpectomy plus irradiation. They decide on (ii). Ten years later, Ms. Smith is alive and the tumor • has not recurred. Her surgeon, Steve, and her radiologist, Rachael de- • bate. Rachael says: “The irradiation prevented the recur- • rence – without it, the tumor would have recurred.” Steve says: “You can’t know that. It’s a fantasy – • you’re making it up. We’ll never know.” 3 Many Causal Questions Steve and Rachael have this debate all the time. • About Ms. Jones, who had lumpectomy alone. About Ms. Davis, whose tumor recurred after a year. Whenever a patient treated with irradiation remains • disease free, Rachael says: “It was the irradiation.” Steve says: “You can’t know that. It’s a fantasy. We’ll never know.” Rachael says: “Let’s keep score, add ’em up.” Steve • says: “You don’t know what would have happened to Ms. Smith, or Ms. Jones, or Ms Davis – you just made it all up, it’s all fantasy. -
Earned Sick Time Faqs
Massachusetts Attorney General’s Office – Earned Sick Time FAQs Earned Sick Time in Massachusetts Frequently Asked Questions These FAQs are based upon the Massachusetts Earned Sick Time Law, M.G.L. c. 149, § 148C, and its accompanying regulations, 940 CMR 33.00. The Earned Sick Time Law sets minimum requirements; employers may choose to provide more generous policies. Table of Contents Section 1: Introduction, Applicability & Eligibility .......................................................................................................... 2 Subsection A: Introduction .......................................................................................................................................... 2 Subsection B: Employees Eligible for Earned Sick Time ............................................................................................... 2 Subsection C: Which Employers Need to Provide Earned Sick Time? ......................................................................... 4 Section 2: Paid versus Unpaid Earned Sick Time ............................................................................................................. 5 Section 3: General Rules .................................................................................................................................................. 6 Subsection A: How is Earned Sick Time Accrued? ....................................................................................................... 6 Subsection B: Carryover of hours from one year to the next .....................................................................................