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Antiviral Chemotherapeutic Agents Against Equine Herpesvirus Type 1: the Mechanism of Antiviral Effects of Porphyrin Derivatives Galena V

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Antiviral Chemotherapeutic Agents Against Equine Herpesvirus Type 1: the Mechanism of Antiviral Effects of Porphyrin Derivatives Galena V Louisiana State University LSU Digital Commons LSU Doctoral Dissertations Graduate School 2009 Antiviral chemotherapeutic agents against equine herpesvirus type 1: the mechanism of antiviral effects of porphyrin derivatives Galena V. Rybachuk Louisiana State University and Agricultural and Mechanical College Follow this and additional works at: https://digitalcommons.lsu.edu/gradschool_dissertations Part of the Veterinary Pathology and Pathobiology Commons Recommended Citation Rybachuk, Galena V., "Antiviral chemotherapeutic agents against equine herpesvirus type 1: the mechanism of antiviral effects of porphyrin derivatives" (2009). LSU Doctoral Dissertations. 2545. https://digitalcommons.lsu.edu/gradschool_dissertations/2545 This Dissertation is brought to you for free and open access by the Graduate School at LSU Digital Commons. It has been accepted for inclusion in LSU Doctoral Dissertations by an authorized graduate school editor of LSU Digital Commons. For more information, please [email protected]. ANTIVIRAL CHEMOTHERAPEUTIC AGENTS AGAINST EQUINE HERPESVIRUS TYPE 1: THE MECHANISM OF ANTIVIRAL EFFECTS OF PORPHYRIN DERIVATIVES A Dissertation Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College in partial fulfillment of the requirements for the degree of Doctor of Philosophy in The Interdepartmental Program in Veterinary Medical Sciences through the Department of Pathobiological Sciences by Galena V. Rybachuk B.S., Louisiana State University, 1997 B.S., Louisiana State University, 1997 DVM, Louisiana State University, 2007 May 2009 ©Copyright 2009 Galena Victorovna Rybachuk All Rights Reserved ii DEDICATION This work is in memory of my grandmother, Anna Evtihievna Vedenina-Juravel, a strong, enthusiastic, inspiring, brave, and kind lady that shaped my life, personality, and heart. She was always drawn to her home, vast rose garden, and orchid in the hard working city of Dneprodzerjunsk, Ukraine. I can still taste the raspberries, mulberries, plums, and young potatoes of her garden. She would let me sleep late and offer delicious treats when I woke up, inspiring me to work very hard without ever directing to do so or scolding. Her home was a haven for my sister, my niece, and I, a peaceful retreat, a place to be truly yourself, and a place to try your very best. Our beloved grandma passed away in June of 2002. I did not have a chance to be there for her in the last years, while she patiently waited for me to come back during all those years. I want everyone reading this work to know about the great lady that had only three years of elementary education and managed to make the world a better place for hundreds of people of many generations, while never compromising the quest for kindness and honesty. Grandma, I will always love you. I would also like to mention the lady who will always be a part of my life, but who I have never had the great honor of meeting, except through the eyes and hearts of her husband and two sons, Yvonne Louise Desiree Quist-Geerinck. Her husband and children were her life. She worked very hard her entire life, never asked anything for herself, and always placed others first, no matter what. She raised a son, Sebastiaan Sam Quist, who gave me the strength to try and passion to learn, showed me how to be true to myself and honest with others no matter the challenges, and gave me my family, reuniting every generation. She fought hard and brave until cancer took her away from us in October of 2001. I will forever admire her and cherish her memory. iii ACKNOWLEDGEMENTS First, and foremost, I would like to thank my loved ones. This work is tribute to my family, as it is their accomplishment in every aspect. I missed many special moments in their lives, as they selflessly encouraged me to live mine. My mom and dad, Nellie Grigorievna Videnina and Viktor Pavlovich Rybachuk, I love you so much. You have been so unbelievably strong for all of us. You have been through so much, and I always wished to be there, right there by your side, every second of the last years, to make your tasks easier and more fun, to cheer you up and to divide up the bad times. Your great example, your infinite enthusiasm to make the world better, you excellence in everything you have done and do, are met with my greatest respect and admiration. The bottomless well of your energy has given so much to people. You have dedicated your life to other people, to science, to the future, to a better, more kind, and honest world. You have always been true to yourself, to us and to your beliefs. I absolutely adore Yuna, Michel, and Vita Videnina-Soulie. I miss the wonderful and blissful times. Your unconditional friendship and love, inspiring hard work, tales of adventures, and the open-minded views on the world and its people have reasured me that there is a lion’s share of good in this world. Vita, your clever awareness and resourcefulness in any matter, mischievous and free spirit, creativity and ability to notice the most delightful things are pure perfection. Thank you all for making the stars align, so I could meet Sebastiaan. And to my love, my soul mate, to my strength and inspiration, Sebastiaan Sam Quist, you are my life. I am forevermore grateful for your love, your friendship, your endless nights studying with me, and your endless patience when I was overwhelmed, and iv I do mean endless! Your approval and support gave me insurmountable strength. You made me realize that we can do anything if we get our minds and hearts together. To my Dutch dad, Samuel J. J. Quist, always with great understanding, wisdom, and patience, no matter what crazy things I come up with, your unconditional love and care are the height of the kindness that’s humanly possible. To Bart F.P. Quist, for being the best loving brother that one can have, and of course, your music that kept me awake during those crazy nights of studying. You rock. To Uncle Nicolai, grandma Valya and grandpa Pavel, I miss you very much and I wish I said all the things I wanted to say. To uncle Vasya, I am grateful that you have always been there for my grandparents and my Dad. To the Rybachuk and Quist families and friends, thank you. To Vladimir and Tamara Chouljenko, Dmitry and Alexander, you have been my family, my friends and mentors. Just your presence in the lab was enough to make it a great day. I admire you, your strength, your determination, your love for each other and open heart to others. To Dr. Kousoulas, you really took care of me and my fellow lab ‘animals’ over the years. You worried about tomorrow for us, gave plenty of rope, encouraged and guided us. We never had to worry if we would have enough plastics, reagents, or assistantships. You spoiled us with computers and state-of-the-art instruments. You encouraged us to share our knowledge and take on various projects. You provided us with the true academic freedom that made us who we are today. You shaped us professionally and personally. v Elena and Effie Kousoulas, thank you for letting us keep Dr. Kousoulas on weekends and late hours. Thank you for always welcoming us to your home, for delicious meals, and good times. To my committee, Dr. Moore, Dr. Larkin, Dr. Foil, Dr. Sehgal, and Dr. Chowdhury. I have the deepest gratitude for your support, patience, encouragement and shared knowledge. To the entire BIOMMED, thank you. Dr. Abolghasem Baghian has taught me everything I know about the cell and tissue culture. He taught me that it is possible to have a perfect order in what seems as a chaos, and that a humble, kind, and quiet man speaks loudest. To Lieutenant Curtis St. Pierre, Lieutenant LeShawn, Officer Jack, Officer Babin, thank you for your friendship, patience, reassuring and tireless rounds and the optimism during those long nights of studying, experiments, and forgetting to bring my badge. You made LSU Veterinary School my home. To my lifelong friends, Maria Esbri, Curtis St. Pierre, Ahmet Binselam, Arun Iyer, Carmen Nassarre, and Azra Baksic and those wonderful times when they taught me what friendship and college years actually mean. To Dr. Fairchild, Dr. Hosgood, Dr. Moore, and Dr. Mitchell, doctors I admire the most, thank you for the perfect examples of the veterinarian that I want to be. To Dr. Klei, thank you for giving me a chance, for your patient support of my DVM/PhD program, for the countless letters and petitions on my account, and for your kind encouragement. vi This work was supported by Division of Biotechnology & Molecular Medicine (BIOMMED), Departments of Pathobiological Sciences, Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA; Jockey Club and the National Institute of Allergy and Infectious Diseases grant AI43000 to Dr. Konstantin Gus Kousoulas. vii TABLE OF CONTENTS DEDICATION ..................................................................................................................... iii ACKNOWLEDGEMENTS ................................................................................................ iv LIST OF TABLES .............................................................................................................. xi LIST OF FIGURES ........................................................................................................... xii LIST OF ABBREVIATTIONS ...................................................................................... xviii ABSTRACT ......................................................................................................................
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