US 20070116831A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0116831 A1 Prakash et al. (43) Pub. Date: May 24, 2007

(54) DENTAL COMPOSITION WITH Publication Classification HIGH-POTENCY SWEETENER (51) Int. Cl. (75) Inventors: Indra Prakash, Alpharetta, GA (US); A2.3L I/236 (2006.01) Grant E. DuBois, Roswell, GA (US) (52) U.S. Cl...... 426/548 Correspondence Address: SUTHERLAND ASBILL & BRENNAN LLP (57) ABSTRACT 999 PEACHTREE STREET, N.E. ATLANTA, GA 30309 (US) The present invention relates generally to dental composi tions comprising non-caloric or low-caloric high-potency (73) Assignee: THE COCA-COLA COMPANY., Sweeteners and methods for making and using them. In Atlanta, GA (US) particular, the present invention relates to different dental compositions comprising at least one non-caloric or low (21) Appl. No.: 11/556,052 caloric natural and/or synthetic high-potency Sweetener, at (22) Filed: Nov. 2, 2006 least one Sweet taste improving composition, and an active dental Substance. The present invention also relates to dental Related U.S. Application Data compositions and methods that can improve the tastes of non-caloric or low-caloric natural and/or synthetic, high (60) Provisional application No. 60/739,302, filed on Nov. potency Sweeteners by imparting a more Sugar-like taste or 23, 2005. Provisional application No. 60/739,124, characteristic. In particular, the dental compositions and filed on Nov. 23, 2005. Provisional application No. methods provide a more Sugar-like temporal profile, includ 60/805.216, filed on Jun. 19, 2006. Provisional appli ing Sweetness onset and Sweetness linger, and/or a more cation No. 60/805,209, filed on Jun. 19, 2006. Sugar-like flavor profile.

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DENTAL COMPOSITION WITH HIGH-POTENCY expanded. Accordingly, it would be desirable to selectively SWEETENER modify the taste characteristics of natural and synthetic high-potency Sweeteners. RELATED APPLICATION DATA 0001. The present application claims priority under 35 SUMMARY OF THE INVENTION U.S.C. S 119 to U.S. Provisional Application No. 60/739, 0005 Generally, this invention addresses the above 302, entitled “Natural High-Potency Sweetener Composi described need by providing a dental composition having tions With Improved Temporal Profile And/Or Flavor Pro improved temporal profile and/or flavor profile and a method file, Methods For Their Formulations, and Uses, filed on for improving the temporal profile and/or flavor profile for Nov. 23, 2005: U.S. Provisional Application No. 60/739, dental compositions. In particular, this invention improves 124, entitled “Synthetic Sweetener Compositions with the temporal profile and/or flavor profile by imparting a Improved Temporal Profile and/or Flavor Profile, Methods more sugar-like temporal profile and/or flavor profile. More for Their Formulation, and Uses, filed on Nov. 23, 2005; particularly, this invention comprises a dental composition U.S. Provisional Application No. 60/805,209, entitled comprising an active dental Substance; at least one high “Natural High-Potency Tabletop Sweetener Compositions potency Sweetener, and at least one Sweet taste improving with Improved Temporal and/or Flavor Profiles, Methods for composition. Their Formulation, and Uses, filed on Jun. 19, 2006; and 0006 Objects and advantages of the invention will be set U.S. Provisional Application No. 60/805,216, entitled forth in part in the following description, or may be obvious “Rebaudioside A Composition and Method for Purifying from the description, or may be learned through practice of Rebaudioside A, filed on Jun. 19, 2006. These applications the invention. Unless otherwise defined, all technical and are hereby incorporated by reference in their entirety. scientific terms and abbreviations used herein have the same meaning as commonly understood by one of ordinary skill FIELD OF THE INVENTION in the art to which this invention pertains. Although methods 0002 The present invention relates generally to a dental and compositions similar or equivalent to those described composition comprising a high-potency Sweetener compo herein can be used in practice of the present invention, sition with improved temporal profile and/or flavor profile. suitable methods and compositions are described without intending that any such methods and compositions limit the BACKGROUND OF THE INVENTION invention herein. 0003 Natural caloric sugars, such as sucrose, fructose, BRIEF DESCRIPTION OF THE DRAWINGS and glucose are utilized heavily in beverage, food, dental, and oral hygienic/cosmetic industries due to their pleasant 0007 FIG. 1 is a powder X-ray diffraction scan of rebau taste. In particular, Sucrose imparts a desirable taste for dioside A polymorph Form 1 on a plot of the scattering consumers. Although Sucrose provides Superior Sweetness intensity versus the scattering angle 20 in accordance with characteristics, it is caloric. While calories are necessary for an embodiment of this invention. proper bodily functions, there is a need in the market to 0008 FIG. 2 is a powder X-ray diffraction scan of rebau provide alternative non-caloric or low-caloric Sweeteners dioside A polymorph Form 2 on a plot of the scattering with Sugar-like taste for consumers with sedentary lifestyles intensity versus the scattering angle 20 in accordance with or those who are calorie conscious. However, in general, an embodiment of this invention. non-caloric or low caloric Sweeteners have associated unde sirable tastes to consumers such as delayed Sweetness onset; 0009 FIG. 3 is a powder X-ray diffraction scan of rebau lingering Sweet aftertaste; bitter taste; metallic taste; astrin dioside A polymorph Form 3A on a plot of the scattering gent taste; cooling taste; licorice-like taste; and/or the like. intensity versus the scattering angle 20 in accordance with an embodiment of this invention. 0004 For example, the sweet tastes of natural and/or synthetic high-potency Sweeteners are slower in onset and 0010 FIG. 4 is a powder X-ray diffraction scan of rebau longer in duration than the Sweet taste produced by Sugar dioside A polymorph Form 3B on a plot of the scattering and thus change the taste balance of a food composition. intensity versus the scattering angle 20 in accordance with Because of these differences, use of a natural high-potency an embodiment of this invention. Sweetener to replace a bulk Sweetener, such as Sugar, in a 0011 FIG. 5 is a powder-X-ray diffraction scan of rebau food or beverage, causes an unbalanced temporal profile dioside A polymorph Form 4 on a plot of the scattering and/or flavor profile. In addition to the difference in temporal intensity versus the scattering angle 20 in accordance with profile, high-potency Sweeteners generally exhibit (i) lower an embodiment of this invention. maximal response than Sugar, (ii) off tastes including bitter, metallic, cooling, astringent, licorice-like taste, etc., and/or DETAILED DESCRIPTION OF THE (iii) Sweetness which diminishes on iterative tasting. It is INVENTION well known to those skilled in the art of food/beverage formulation that changing the Sweetener in a composition 0012 Reference now will be made in detail to the pres requires re-balancing of the flavor and other taste compo ently proffered embodiments of the invention. Each example nents (e.g., acidulants). If the taste profile of natural and is provided by way of explanation of embodiments of the synthetic high-potency Sweeteners could be modified to invention, not limitation of the invention. In fact, it will be impart specific desired taste characteristics to be more apparent to those skilled in the art that various modifications Sugar-like, the type and variety of compositions that may be and variations can be made in the present invention without prepared with that sweetener would be significantly departing from the spirit or scope of the invention. For US 2007/01 16831 A1 May 24, 2007

instance, features illustrated or described as part of one not limited to, water, sodium lauryl sulfate or other sulfates, embodiment, can be used on another embodiment to yield a humectants, enzymes, vitamins, herbs, calcium, flavorings still further embodiment. Thus, it is intended that the present (e.g., mint, bubblegum, cinnamon, lemon, or orange), Sur invention cover Such modifications and variations within the face-active agents, binders, preservatives, gelling agents, pH Scope of the appended claims and their equivalents. modifiers, peroxide activators, stabilizers, coloring agents, 0013 Generally described, embodiments of the present or similar type materials, or combinations thereof invention provide dental compositions comprising at least one natural and/or synthetic high-potency Sweetener, at least 0019. The base material of the dental composition may one Sweet taste improving composition, and an active dental optionally include other artificial or natural Sweeteners, bulk Substance. sweeteners, or combinations thereof Bulk sweeteners include both caloric and non-caloric compounds. In a par I. Dental Compositions ticular embodiment, the Sweet taste improving composition 0014 Dental compositions generally comprise an active functions as the bulk Sweetener. Non-limiting examples of dental Substance and a base material. The base material bulk Sweeteners include Sucrose, dextrose, maltose, dextrin, typically includes the at least one natural and/or synthetic dried invert Sugar, fructose, high fructose corn syrup, levu high-potency Sweetener and the at least one Sweet taste lose, galactose, corn Syrup Solids, tagatose, polyols (e.g., improving composition. The dental composition may be in sorbitol, mannitol, xylitol, lactitol, erythritol, and maltitol), the form of any oral composition used in the oral cavity Such hydrogenated Starch hydrolysates, isomalt, trehalose, and as mouth freshening agents, gargling agents, mouth rinsing mixtures thereof. Generally, the amount of bulk sweetener agents, toothpaste, tooth polish, dentifrices, mouth sprays, present in the dental composition ranges widely depending teeth-whitening agent, dental floss, and the like, for on the particular embodiment of the dental composition and example. the desired degree of sweeteness. Those of ordinary skill in 0015. As referred to herein, “active dental substance” the art will readily ascertain the appropriate amount of bulk means any composition which can be used to improve the sweetener. In particular embodiments, the bulk sweetener is aesthetic appearance and/or health of teeth or gums or present in the dental composition in an amount in the range prevent dental caries. As referred to herein, “base material of about 0.1 to about 5 weight percent of the dental com refers to any inactive Substance used as a vehicle for an position. active dental Substance, such as any material to facilitate 0020. According to particular embodiments of the inven handling, stability, dispersibility, wettability, foaming, and/ tion, the base material is present in the dental composition or release kinetics of an active dental Substance. in an amount ranging from about 20 to about 99 percent by 0016 Suitable active dental substances for embodiments weight of the dental composition. Generally, the base mate of this invention include, but are not limited to, substances rial is present in an amount effective to provide a vehicle for which remove dental plaque, remove food from teeth, aid in an active dental Substance. the elimination and/or masking of halitosis, prevent tooth decay, and prevent gum disease (i.e., Gingiva). Examples of 0021. In a particular embodiment, a dental composition suitable active dental substances for embodiments of the comprises at least one natural and/or synthetic high-potency present invention include, but are not limited to, anticaries Sweetener in combination with at least one Sweet taste drugs, fluoride, Sodium fluoride, Sodium monofluorophos improving composition and an active dental Substance. phate, Stannos fluoride, hydrogen peroxide, carbamide per Generally, the amount of the at least one natural and/or oxide (i.e., urea peroxide), antibacterial agents, plaque synthetic high potency Sweetener varies widely depending removing agents, stain removers, anticalculus agents, abra on the nature of the particular dental composition and the sives, baking Soda, perearbonates, perborates of alkali and desired degree of sweetness. Those skilled in the art will be alkaline earth metals, or similar type Substances, or combi able to discern a suitable amount of Sweetener for such nations thereof. Such components generally are recognized dental composition. In a particular embodiment, the at least as safe (GRAS) and/or are U.S. Food and Drug Adminis one natural and/or synthetic high-potency Sweetener is tration (FDA)-approved. present in the dental composition in an amount in the range of about 1 to about 5,000 ppm of the dental composition and 0017 According to particular embodiments of the inven the at least one Sweet taste improving composition is present tion, the active dental Substance is present in the dental in the dental composition in an amount in the range of about composition in an amount ranging from about 50 ppm to 0.1 to about 100,000 ppm of the dental composition. about 3000 ppm of the dental composition. Generally, the active dental Substance is present in the dental composition II. Sweetener Compositions in an amount effective to at least improve the aesthetic 0022. As described hereinabove, the dental compositions appearance and/or health of teeth or gums marginally or comprise at least one natural and/or synthetic high-potency prevent dental caries. For example, a dental composition Sweetener and at least one Sweet taste improving composi comprising a toothpaste may include an active dental Sub tion. The combination of the at least one natural and/or stance comprising fluoride in an amount of about 850 to synthetic high-potency Sweetener and at least one Sweet 1,150 ppm. taste improving composition, as used herein, comprises the 0018. The dental composition also may comprise other 'Sweetener composition.” As used herein, an active dental base materials in addition to the at least one natural and/or Substance is synonymous with a “sweetenable composition.” synthetic high-potency Sweetener and the at least one Sweet In addition, the combination of the Sweetener composition taste improving composition. Examples of Suitable base and an active dental Substance comprises a 'sweetened materials for embodiments of this invention include, but are composition.” US 2007/01 16831 A1 May 24, 2007

0023 A. Natural High-Potency Sweeteners nol, methanol, isopranol. 1-propanol, 1-butanol, 2-butanol, 0024 Desirably, the sweetener composition comprises at tert-butanol, and isobutanol. Desirably, the at least one least one natural and/or synthetic high-potency Sweetener. organic solvent comprises a mixture of ethanol and metha As used herein the phrases “natural high-potency Sweet nol present in the aqueous organic Solution in a weight ratio ener”, “NHPS”, “NHPS composition”, and “natural high ranging from about 20 parts to about 1 part ethanol to 1 part potency sweetener composition” are synonymous. “NHPS methanol, more desirably from about 3 parts to about 1 part means any Sweetener found in nature which may be in raw, ethanol to 1 part methanol. extracted, purified, or any other form, singularly or in 0029 Desirably, the weight ratio of the aqueous organic combination thereof and characteristically have a Sweetness solvent and crude rebaudioside A ranges from about 10 to potency greater than Sucrose, fructose, or glucose, yet have about 4 parts aqueous organic solvent to 1 part crude less calories. Non-limiting examples of NHPSs suitable for rebaudioside A, more particularly from about 5 to about 3 embodiments of this invention include rebaudioside A, parts aqueous organic solvent to 1 part crude rebaudioside A. rebaudioside B, rebaudioside C, rebaudioside D, rebaudio 0030. In an exemplary embodiment, the method of puri side EF, rebaudioside F, dulcoside A, dulcoside B, rubuso fying rebaudioside A is carried out at approximately room side, Stevia, Stevioside, mogroside IV. mogroside V, Luo temperature. In another embodiment, the method of purify Han Guo Sweetener, Siamenoside, monatin and its salts ing rebaudioside A further comprises the step of heating the (monatin SS, RR, RS, SR), curculin, glycyrrhizic acid and rebaudioside A Solution to a temperature in a range from its salts, thaumatin, monellin, mabinlin, braZZein, herman about 20° C. to about 40° C., or in another embodiment to dulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, a reflux temperature, for about 0.25 hours to about 8 hours. baiyunoside, osladin, polypodoside A, pterocaryoside A, In another exemplary embodiment, wherein the method for pterocaryoside B, mukurozioside, phlomisoside I, perian purifying rebaudioside A comprises the step of heating the drin I, abrusoside A, and cyclocarioside I. NHPS also rebaudioside A solution, the method further comprises the includes modified NHPSs. Modified NHPSS include NHPSS step of cooling the rebaudioside A Solution to a temperature which have been altered naturally. For example, a modified in the range from about 4°C. to about 25°C. for about 0.5 NHPS includes, but is not limited to, NHPSs which have hours to about 24 hours. been fermented, contacted with enzyme, or derivatized or 0031. According to particular embodiments, the purity of substituted on the NHPS. In one embodiment, at least one rebaudioside A may range from about 50% to about 100%: modified NHPS may be used in combination with at least from about 70% to about 100%; from about 80% to about one NHPS. In another embodiment, at least one modified 100%; from about 90% to about 100%; from about 95% to NHPS may be used without a NHPS. Thus, modified NHPSs about 100%; from about 95% to about 99.5%; about 96% to may be substituted for a NHPS or may be used in combi about 100%; from about 97% to about 100%; from about nation with NHPSs for any of the embodiments described 98% to about 100%; and from about 99% to about 100%. herein. For the sake of brevity, however, in the description According to particularly desirable embodiments, upon of embodiments of this invention, a modified NHPS is not crystallization of crude rebaudioside A, the substantially expressly described as an alternative to an unmodified pure rebaudioside A composition comprises rebaudioside A NHPS, but it should be understood that modified NHPSs can in a purity greater than about 95% by weight up to about be substituted for NHPSs in any embodiment disclosed 100% by weight on a dry basis. In other exemplary embodi herein. ments, Substantially pure rebaudioside A comprises purity 0.025 Purity, as used here, represents the weight percent levels of rebaudioside Agreater than about 97% up to about age of a respective NHPS compound present in a NHPS 100% rebaudioside A by weight on a dry basis, greater than extract, in raw or purified form. In one embodiment, a about 98% up to about 100% by weight on a dry basis, or Steviolglycoside extract comprises a particular Steviolglyco greater than about 99% up to about 100% by weight on a dry side in a particular purity, with the remainder of the basis. The rebaudioside A Solution during the single crys Stevioglycoside extract comprising a mixture of other Ste tallization step may be stirred or unstirred. violglycosides. 0032. In an exemplary embodiment, the method of puri 0026. To obtain a particularly pure extract of a NHPS, fying rebaudioside A further comprises the step of seeding Such as rebaudioside A, it may be necessary to purify the (optional step) the rebaudioside A Solution at an appropriate crude extract to a substantially pure form. Such methods temperature with high-purity crystals of rebaudioside A generally are known to those of ordinary skill in the art. sufficient to promote crystallization of the rebaudioside A to form pure rebaudioside A. An amount of rebaudioside A 0027. An exemplary method for purifying a NHPS, such sufficient to promote crystallization of substantially pure as rebaudioside A, is described in the co-pending patent rebaudioside A comprises an amount of rebaudioside A from application No. 60/805.216, entitled “Rebaudioside A Com about 0.0001% to about 1% by weight of the rebaudioside position and Method for Purifying Rebaudioside A, filed on A present in the solution, more particularly from about Jun. 19, 2006, by inventors DuBois, et al., the disclosure of 0.01% to about 1% by weight. An appropriate temperature which is incorporated herein by reference in its entirety. for the step of seeding comprises a temperature in a range 0028 Briefly described, substantially pure rebaudioside from about 18° C. to about 35° C. A is crystallized in a single step from an aqueous organic 0033. In another exemplary embodiment, the method of Solution comprising at least one organic solvent and water in purifying rebaudioside A further comprises the steps of an amount from about 10% to about 25% by weight, more separating and washing the Substantially pure rebaudioside particularly from about 15% to about 20% by weight. A composition. The Substantially pure rebaudioside A com Organic solvents desirably comprise alcohols, acetone, and position may be separated from the aqueous organic Solution acetonitile. Non-limiting examples of alcohols include etha by a variety of Solid-liquid separation techniques that utilize US 2007/01 16831 A1 May 24, 2007

centrifugal force, that include, without limitation, vertical Solvent to 1 part Substantially pure rebaudioside A compo and horizontal perforated basket centrifuge, solid bowl cen sition. In one embodiment, the slurry is maintained at room trifuge, decanter centrifuge, peeler type centrifuge, pusher temperature. In another embodiment, the step of slurrying type centrifuge, Heinkel type centrifuge, disc stack centri comprises heating the slurry to a temperature in a range from fuge and cyclone separation. Additionally, separation may about 20° C. to about 40°C. The substantially pure rebau be enhanced by any of pressure, vacuum, and gravity dioside A composition is slurried for about 0.5 hours to filtration methods, that include, without limitation, the use of about 24 hours. belt, drum, nutsche type, leaf plate, Rosenmund type, sparkler type, and bag filters and filter press. Operation of 0036). In still yet another exemplary embodiment, the the rebaudioside A solid-liquid separation device may be method of purifying rebaudioside A further comprises the continuous, semi-continuous or in batch mode. The Substan steps of separating the Substantially pure rebaudioside A tially pure rebaudioside A composition also may be washed composition from the aqueous organic or organic solvent of on the separation device using various aqueous organic the slurry and washing the Substantially pure rebaudioside A solvents and mixtures thereof. The substantially pure rebau composition followed by the step of drying the substantially dioside A composition can be dried partially or totally on the pure rebaudioside A composition. separation device using any number of gases, including, without limitation, nitrogen and argon, to evaporate residual 0037) If further purification is desired, the method of liquid solvent. The substantially pure rebaudioside A com purifying rebaudioside A described herein may be repeated position may be removed automatically or manually from or the Substantially pure rebaudioside A composition may be the separation device using liquids, gases or mechanical purified further using an alternative purification method, means by either dissolving the Solid or maintaining the Solid Such as the column chromatography. form. 0038. It also is contemplated that other NHPSs may be 0034. In still another exemplary embodiment, the method purified using the purification method described herein, of purifying rebaudioside A further comprises the step of requiring only minor experimentation that would be obvious drying the Substantially pure rebaudioside A composition to those of ordinary skill in the art. using techniques well known to those skilled in the art, 0039 The purification of rebaudioside A by crystalliza non-limiting examples of which include the use of a rotary tion as described above results in the formation of at least vacuum dryer, fluid bed dryer, rotary tunnel dryer, plate three different polymorphs: Form 1: a rebaudioside A dryer, tray dryer, Nauta type dryer, spray dryer, flash dryer, hydrate; Form 2: an anhydrous rebaudioside A; and Form 3: micron dryer, pan dryer, high and low speed paddle dryer a rebaudioside A solvate. In addition to the at least three and microwave dryer. In an exemplary embodiment, the step polymorph forms of rebaudioside A, the purification of of drying comprises drying the Substantially pure rebaudio rebaudioside A may result in the formation of an amorphous side A composition using a nitrogen or argon purge to form of rebaudioside A, Form 4. The aqueous organic remove the residual solvent at a temperature in a range from Solution and temperature of the purification process influ about 40° C. to about 60° C. for about 5 hours to about 100 ence the resulting polymorph and amorphous forms in the hours. substantially pure rebaudioside A composition. FIGS. 1-5 0035) In yet another exemplary embodiment, wherein the are exemplary powder X-ray diffraction (XRPD) scans of the crude rebaudioside A mixture comprises Substantially no polymorph and amorphous forms Form 1 (hydrate), Form 2 rebaudioside D impurity, the method of purifying rebaudio (anhydrate). Form 3A (methanol solvate), Form 3B (ethanol side A further comprises the step of slurrying the composi Solvate), and Form 4 (amorphous), respectively. The mate tion of Substantially pure rebaudioside A with an aqueous rial properties of the three rebaudioside A polymorph and organic solvent prior to the step of drying the Substantially amorphous forms are Summarized in the following table:

TABLE 1. Rebaudioside A Polymorph and Amorphous Forms

Form 1 Form 2 Form 3 Form 4 Polymorph Polymorph Polymorph Amorphous Rate of dissolution Very low (<0.2%, Intermediate (<30%f High (>30%/5 High (>35%/5 in H2O at 25° C. 60 minutes) 5 minutes) minutes) minutes) Alcohol content &O.S90 &1% 1-3% <0.05% Moisture content >5% &1% &3% 6.74% pure rebaudioside A composition. The slurry is a mixture 0040. The type of polymorph formed is dependent on the comprising a Solid and an aqueous organic or organic composition of the aqueous organic Solution, the tempera solvent, wherein the solid comprises the substantially pure ture of the crystallization step, and the temperature during rebaudioside A composition and is only sparingly soluble in the drying step. Form 1 and Form 3 are formed during the the aqueous organic or organic solvent. In an embodiment, single crystallization step while Form 2 is formed during the the Substantially pure rebaudioside A composition and aque drying step after conversion from Form 1 or Form 3. ous organic solvent are present in the slurry in a weight ratio 0041 Low temperatures during the crystallization step, in ranging from about 15 parts to 1 part aqueous organic the range of about 20° C. to about 5°C., and a low ratio of US 2007/01 16831 A1 May 24, 2007

water to the organic solvent in the aqueous organic solvent combined include rebaudioside A, rebaudioside B, rebau results in the formation of Form 3. High temperatures during dioside C, rebaudioside D, rebaudioside E, rebaudioside F, the crystallization step, in the range of about 50° C. to about dulcoside A, dulcoside B, rubusoside, Stevioside, or stevio 80°C., and a high ratio of water to the organic solvent in the lbioside. According to particularly desirable embodiments of aqueous organic Solvent results in the formation of the Form the present invention, the combination of high-potency 1. Form 1 can be converted to Form 3 by slurrying in an Sweeteners comprises rebaudioside A in combination with anhydrous solvent at room temperature (2-16 hours) or at rebaudioside B, rebaudioside C, rebaudioside F, rebaudio reflux for approximately (0.5-3 hours). Form 3 can be side F. Stevioside, Steviolbioside, dulcoside A, or combina converted to Form 1 by slurrying the polymorph in water at tions thereof. room temperature for approximately 16 hours or at reflux for approximately 2-3 hours. Form 3 can be converted to the 0048 Generally, according to a particular embodiment, Form 2 during the drying process; however, increasing rebaudioside A is present in the combination of high-potency either the drying temperature above 70° C. or the drying Sweeteners in an amount in the range of about 50 to about time of a substantially pure rebaudioside A composition can 99.5 weight percent of the combination of high-potency result in decomposition of the rebaudioside A and increase sweeteners, more desirably in the range of about 70 to about the remaining rebaudioside B impurity in the substantially 90 weight percent, and still more desirably in the range of pure rebaudioside A composition. Form 2 can be converted about 75 to about 85 weight percent. to Form 1 with the addition of water. 0049. In another particular embodiment, rebaudioside B 0.042 Form 4 may be formed from Form 1, 2, 3, or is present in the combination of high-potency Sweeteners in combinations thereof, using methods well known to those of an amount in the range of about 1 to about 8 weight percent ordinary skill in the art. Non-limiting examples of Such of the combination of high-potency Sweeteners, more desir methods include melt-processing, hall milling, crystalliza ably in the range of about 2 to about 5 weight percent, and tion, lyophilization, cryo-grinding, and spray-drying. In a still more desirably in the range of about 2 to about 3 weight particular embodiment, Form 4 can be prepared from a percent. substantially pure rebaudioside A composition obtained by 0050. In another particular embodiment, rebaudioside C the purification methods described hereinabove by spray is present in the combination of high-potency Sweeteners in drying a solution of the Substantially pure rebaudioside A an amount in the range of about 1 to about 10 weight percent composition. of the combination of high-potency Sweeteners, more desir ably in the range of about 3 to about 8 weight percent, and 0043. B. Synthetic High-Potency Sweeteners still more desirably in the range of about 4 to about 6 weight 0044 As used herein, the phrase “synthetic sweetener” percent. refers to any compositions which are not found in nature and 0051. In still another particular embodiment, rebaudio characteristically have a Sweetness potency greater than side E is present in the combination of high-potency Sweet Sucrose, fructose, or glucose, yet have less calories. Non eners in an amount in the range of about 0.1 to about 4 limiting examples of synthetic Sweeteners Suitable for weight percent of the combination of high-potency Sweet embodiments of this invention include Sucralose, potassium acesulfame, aspartame, alitame, Saccharin, neohesperidin eners, more desirably in the range of about 0.1 to about 2 dihydrochalcone, cyclamate, neotame, N-N-3-(3-hydroxy weight percent, and still more desirably in the range of about 4-methoxyphenyl)propyl-L-C.-aspartyl-L-phenylalanine 0.5 to about 1 weight percent. 1-methyl ester, N-N-3-(3-hydroxy-4-methoxyphenyl)-3- 0052. In still another particular embodiment, rebaudio methylbutyl-L-C.-aspartyl-L-phenylalanine 1-methyl ester, side F is present in the combination of high-potency Sweet N-N-3-(3-methoxy-4-hydroxyphenyl)propyl-L-C.-aspar eners in an amount in the range of about 0.1 to about 4 tyl-L-phenylalanine 1-methyl ester, salts thereof, and the weight percent of the combination of high-potency Sweet like. eners, more desirably in the range of about 0.1 to about 2 weight percent, and still more desirably in the range of about 0045 C. Combinations of Natural and/or Synthetic High 0.5 to about 1 weight percent. Potency Sweeteners 0053. In still yet another particular embodiment, dulco 0046) The NHPS and synthetic sweeteners may be used side A is present in the combination of high-potency Sweet individually or in combination with other NHPS and/or eners in an amount in the range of about 0.1 to about 4 synthetic Sweeteners. For example, the Sweetener composi weight percent of the combination of high-potency Sweet tion may comprise a single NHPS or a single synthetic eners, more desirably in the range of about 0.1 to about 2 sweetener; a single NHPS in combination with a single weight percent, and still more desirably in the range of about synthetic sweetener; one or more NHPSs in combination 0.5 to about 1 weight percent. with a single synthetic sweetener; a single NHPS in com bination with one or more synthetic Sweeteners; or one or 0054. In yet another particular embodiment, dulcoside B more NHPSs in combination with one or more synthetic is present in the combination of high-potency Sweeteners in Sweeteners. A plurality of natural and/or synthetic high an amount in the range of about 0.1 to about 4 weight potency Sweeteners may be used as long as the combined percent of the combination of high-potency Sweeteners, effect does not adversely affect the taste of the Sweetener more desirably in the range of about 0.1 to about 2 weight composition. percent, and still more desirably in the range of about 0.5 to 0047 For example, particular embodiments comprise about 1 weight percent. combinations of NHPSs, such as Steviolglycosides. Non 0055. In another particular embodiment, stevioside is limiting examples of Suitable Stevioglycosides which may be present in the combination of high-potency Sweeteners in an US 2007/01 16831 A1 May 24, 2007

amount in the range of about 0.5 to about 10 weight percent reduce, or eliminate undesirable taste and impart Sugar-like of the combination of high-potency Sweeteners, more desir characteristics to the Sweetener composition. As used herein, ably in the range of about 1 to about 6 weight percent, and the phrase “undesirable taste’ includes any taste property still more desirably in the range of about 1 to about 4 weight which is not imparted by Sugars, e.g. glucose, Sucrose, percent. fructose, or similar saccharides. Non-limiting examples of 0056. In still another particular embodiment, steviolbio undesirable tastes include delayed Sweetness onset, linger side is present in the combination of high-potency Sweet ing Sweet aftertaste, metallic taste, bitter taste, cooling eners in an amount in the range of about 0.1 to about 4 sensation taste or menthol-like taste, licorice-like taste, weight percent of the combination of high-potency Sweet and/or the like. eners, more desirably in the range of about 0.1 to about 2 0062 A. Sweet Taste weight percent, and still more desirably in the range of about 0063. In one embodiment, a sweetener composition 0.5 to about 1 weight percent. exhibits a more Sugar-like temporal and/or Sugar-like flavor 0057 According to a particularly desirable embodiment, profile than a Sweetener composition comprising at least one the high-potency Sweetener composition comprises a com natural and/or synthetic high-potency Sweetener, but without bination of rebaudioside A, Stevioside, rebaudioside B, a Sweet taste improving composition is provided. As used rebaudioside C, and rebaudioside F, wherein rebaudioside A herein, the phrases "Sugar-like characteristic.'sugar-like is present in the combination of high-potency Sweeteners in taste.” Sugar-like Sweet.” Sugary,” and "sugar-like are syn an amount in the range of about 75 to about 85 weight onymous. Sugar-like characteristics include any character percent based on the total weight of the combination of istic similar to that of sucrose and include, but are not limited high-potency Sweeteners, Stevioside is present in an amount to, maximal response, flavor profile, temporal profile, adap in the range of about 1 to about 6 weight percent, rebau tation behavior, mouthfeel, concentration/response function dioside B is present in an amount in the range of about 2 to behavior, tastant and flavor/sweet taste interactions, spatial about 5 weight percent, rebaudioside C is present in an pattern selectivity, and temperature effects. These character amount in the range of about 3 to about 8 weight percent, istics are dimensions in which the taste of sucrose is different and rebaudioside F is present in an amount in the range of from the tastes of natural and synthetic high-potency Sweet about 0.1 to about 2 weight percent. eners. Whether or not a characteristic is more Sugar-like is determined by expert sensory panel assessments of Sugar 0.058. In addition, those of ordinary skill in the art should and compositions comprising at least one natural and/or appreciate that the Sweetener composition can be custom synthetic high-potency Sweetener, both with and without a ized to obtain a desired calorie content. For example, a Sweet taste improving composition. Such assessments quan low-caloric or non-caloric NHPS may be combined with a tify similarities of the characteristics of compositions com caloric natural Sweetener and/or other caloric additives to prising at least one natural and/or synthetic high-potency produce a Sweetener composition with a preferred calorie sweetener, both with and without a sweet taste improving COntent. composition, with those comprising Sugar. Suitable proce III. Sweet Taste Improving Compositions dures for determining whether a composition has a more 0059. The Sweetener composition also comprises a sweet Sugar-like taste are well known in the art. taste improving composition, non-limiting examples of 0064. In a particular embodiment, a panel of assessors is which include carbohydrates, polyols, amino acids and their used to measure the reduction of Sweetness linger. Briefly corresponding salts, polyamino acids and their correspond described, a panel of assessors (generally 8 to 12 individu ing salts, Sugar acids and their corresponding salts, nucle als) is trained to evaluate Sweetness perception and measure otides, organic acids, inorganic acids, organic salts including Sweetness at several time points from when the sample is organic acid salts and organic base salts, inorganic salts, initially taken into the mouth until 3 minutes after it has been bitter compounds, flavorants and flavoring ingredients, expectorated. Using statistical analysis, the results are com astringent compounds, proteins or protein hydrolysates, Sur pared between samples containing additives and samples factants, emulsifiers, flavonoids, alcohols, polymers, other that do not contain additives. A decrease in score for a time Sweet taste improving taste additives imparting Such Sugar point measured after the sample has cleared the mouth like characteristics, and combinations thereof. indicates there has been a reduction in Sweetness perception. 0060. In one embodiment, a single sweet taste improving 0065. The panel of assessors may be trained using pro composition may be used in combination with a single cedures well known to those of ordinary skill in the art. In natural and/or synthetic high-potency Sweetener. In another a particular embodiment, the panel of assessors may be embodiment of the present invention, a single Sweet taste trained using the SpectrumTM Descriptive Analysis Method improving composition may be used in combination with (Meilgaard et al. Sensory Evaluation Technques 3" edition, one or more natural and/or synthetic high-potency Sweeten Chapter 11). Desirably, the focus of training should be the ers. In yet another embodiment, one or more Sweet taste recognition of and the measure of the basic tastes; specifi improving compositions may be used in combination with a cally, Sweet. In order to ensure accuracy and reproducibility single natural and/or synthetic high-potency Sweetener. In a of results, each assessor should repeat the measure of the further embodiment, there may be a plurality of Sweet taste reduction of Sweetness linger about three to about five times improving combinations used in combination with one or per sample, taking at least a five minute break between each more natural and/or synthetic high-potency Sweeteners. repetition and/or sample and rinsing well with water to clear 0061. In a particular embodiment, combinations of at the mouth. least one natural and/or synthetic high-potency Sweetener 0066 Generally, the method of measuring sweetness and at least one Sweet taste improving composition Suppress, comprises taking a 10 mL sample into the mouth, holding US 2007/01 16831 A1 May 24, 2007 the sample in the mouth for 5 seconds and gently Swirling galactose, rhamnose, cyclodextrin (e.g., C-cyclodextrin, the sample in the mouth, rating the Sweetness intensity B-cyclodextrin, and Y-cyclodextrin), maltodextrin (including perceived at 5 seconds, expectorating the sample (without resistant maltodextrins such as Fibersol-2TM), dextran, Swallowing following expectorating the sample), rinsing Sucrose, glucose, ribulose, fructose, threose, arabinose, with one mouthful of water (e.g., vigorously moving water Xylose, lyxose, allose, altrose, mannose, idose, lactose, in mouth as if with mouth wash) and expectorating the rinse maltose, invert Sugar, isotrehalose, neotrehalose, palatinose water, rating the Sweetness intensity perceived immediately or isomalitulose, erythrose, deoxyribose, gulose, idose, upon expectorating the rinse water, waiting 45 seconds and, talose, erythrulose, Xylulose, psicose, turanose, cellobiose, while wating those 45 seconds, identifying the time of amylopectin, glucosamine, mannosamine, fucose, glucu maximum perceived Sweetness intensity and rating the ronic acid, gluconic acid, glucono-lactone, abequose, galac Sweetness intensity at that time (moving the mouth normally tosamine, beet oligosaccharides, isomalto-oligosaccharides and Swallowing as needed), rating the Sweetness intensity (isomaltose, isomaltotriose, panose and the like), Xylo after another 10 seconds, rating the Sweetness intensity after oligosaccharides (Xylotriose, Xylobiose and the like), gentio another 60 seconds (cumulative 120 seconds after rinse), oligoscaccharides (gentiobiose, gentiotriose, gentiotetraose and rating the sweetness intensity after still another 60 and the like), Sorbose, nigero-oligosaccharides, palatinose seconds (cumulative 180 seconds after rinse). Between oligosaccharides, fructooligosaccharides (kestose, nystose samples take a 5 minute break, rinsing well with water to and the like), maltotetraol, maltotriol, malto-oligosaccha clear the mouth. rides (maltotriose, maltotetraose, maltopentaose, malto hexaose, maltoheptaose and the like), lactulose, melibiose, 0067 B. Types of Sweet Taste Improving Compositions raffinose, rhamnose, ribose, isomerized liquid Sugars such as 0068. As described hereinabove, Sweet taste improving high fructose corn/starch syrup (e.g., HFCS55, HFCS42, compositions include carbohydrates, polyols, amino acids HFCS90), coupling Sugars, soybean oligosaccharides, and and their corresponding salts, polyamino acids and their glucose syrup. Additionally, the carbohydrates as used corresponding salts, Sugar acids and their corresponding herein may be in either the D- or L-configuration. salts, nucleotides, organic acids, inorganic acids, organic 0.071) The term “polyol, as used herein, refers to a salts including organic acid salts and organic base salts, molecule that contains more than one hydroxyl group. A inorganic salts, bitter compounds, flavorants and flavoring polyol may be a diol, triol, or a tetraol which contain 2, 3, ingredients, astringent compounds, proteins or protein and 4 hydroxyl groups, respectively. A polyol also may hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, contain more than four hydroxyl groups, such as a pentaol, polymers, other Sweet taste improving taste additives hexaol, heptaol, or the like, which contain, 5, 6, or 7 imparting Such Sugar-like characteristics, and combinations hydroxyl groups, respectively. Additionally, a polyol also thereof. may be a Sugar alcohol, polyhydric alcohol, or polyalcohol 0069. As used herein, the term “carbohydrate” generally which is a reduced form of carbohydrate, wherein the refers to aldehyde or ketone compounds substituted with carbonyl group (aldehyde or ketone, reducing Sugar) has multiple hydroxyl groups, of the general formula (CH2O), been reduced to a primary or secondary hydroxyl group. wherein n is 3-30, as well as their oligomers and polymers. 0072. Non-limiting examples of sweet taste improving The carbohydrates of the present invention can, in addition, polyol additives in embodiments of this invention include be substituted or deoxygenated at one or more positions. erythritol, maltitol, mannitol, sorbitol, lactitol, xylitol, inosi Carbohydrates, as used herein, encompass unmodified car tol, isomalt, propylene glycol, glycerol (glycerine), threitol, bohydrates, carbohydrate derivatives, substituted carbohy galactitol, palatinose, reduced isomalto-oligosaccharides, drates, and modified carbohydrates. As used herein, the reduced Xylo-oligosaccharides, reduced gentio-oligosaccha phrases “carbohydrate derivatives”, “substituted carbohy rides, reduced maltose syrup, reduced glucose syrup, and drate', and “modified carbohydrates' are synonymous. Sugar alcohols or any other carbohydrates capable of being Modified carbohydrate means any carbohydrate wherein at reduced which do not adversely affect the taste of the least one atom has been added, removed, Substituted, or Sweetener composition. combinations thereof Thus, carbohydrate derivatives or sub stituted carbohydrates include substituted and unsubstituted 0073 Suitable sweet taste improving amino acid addi monosaccharides, disaccharides, oligosaccharides, and tives for use in embodiments of this invention include, but polysaccharides. The carbohydrate derivatives or substituted are not limited to, aspartic acid, arginine, glycine, glutamic carbohydrates optionally can be deoxygenated at any cor acid, proline, threonine, theanine, cysteine, cystine, alanine, responding C-position, and/or Substituted with one or more valine, tyrosine, leucine, isoleucine, asparagine, serine, moieties such as hydrogen, halogen, haloalkyl, carboxyl, lysine, histidine, ornithine, methionine, carnitine, aminobu acyl, acyloxy, amino, amido, carboxyl derivatives, alky tyric acid (alpha-, beta-, or gamma-isomers), glutamine, lamino, dialkylamino, arylamino, alkoxy, aryloxy, nitro, hydroxyproline, taurine, nonaline, sarcosine, and their salt cyano, Sulfo, mercapto, imino, Sulfonyl, Sulfenyl, Sulfinyl, forms such as Sodium or potassium salts or acid salts. The Sulfamoyl, carboalkoxy, carboxamido, phosphonyl, phos Sweet taste improving amino acid additives also may be in phinyl, phosphoryl, phosphino, thioester, thioether, oXimino, the D- or L-configuration and in the mono-, di-, or tri-form hydrazino, carbamyl, phospho, phosphonato, or any other of the same or different amino acids. Additionally, the amino viable functional group provided the carbohydrate deriva acids may be Cl-, 3-, y-, 6-, and e-isomers if appropriate. tive or substituted carbohydrate functions to improve the Combinations of the foregoing amino acids and their cor Sweet taste of the Sweetener composition. responding salts (e.g., sodium, potassium, calcium, magne sium salts or other alkali or alkaline earth metal salts thereof, 0070. Non-limiting examples of carbohydrates in or acid salts) also are suitable Sweet taste improving addi embodiments of this invention include tagatose, trehalose, tives in embodiments of this invention. The amino acids may US 2007/01 16831 A1 May 24, 2007

be natural or synthetic. The amino acids also may be moiety. Suitable Sweet taste improving organic acid addi modified. Modified amino acids refers to any amino acid tives for use in embodiments of this invention include, but wherein at least one atom has been added, removed, Sub are not limited to, C2-C30 carboxylic acids, substituted stituted, or combinations thereof (e.g., N-alkyl amino acid, hydroxyl C1-C30 carboxylic acids, benzoic acid, substituted N-acyl amino acid, or N-methyl amino acid). Non-limiting benzoic acids (e.g. 2,4-dihydroxybenzoic acid), Substituted examples of modified amino acids include amino acid cinnamic acids, hydroxyacids, Substituted hydroxybenzoic derivatives such as trimethylglycine, N-methyl-glycine, and acids, Substituted cyclohexyl carboxylic acids, tannic acid, N-methyl-alanine. As used herein, amino acids encompass lactic acid, tartaric acid, citric acid, gluconic acid, gluco both modified and unmodified amino acids. As used herein, heptonic acids, adipic acid, hydroxycitric acid, malic acid, modified amino acid also may encompass peptides and fruitaric acid (a blend of malic, fumaric, and tartaric acids), polypeptides (e.g., dipeptides, tripeptides, tetrapeptides, and fumaric acid, maleic acid, Succinic acid, chlorogenic acid, pentapeptides) such as glutathione and L-alanyl-L- salicylic acid, creatine, glucosamine hydrochloride, glucono glutamine. delta lactone, caffeic acid, bile acids, acetic acid, ascorbic acid, alginic acid, erythorbic acid, polyglutamic acid, and 0074 Suitable sweet taste improving polyamino acid their alkali or alkaline earth metal salt derivatives thereof. In additives include poly-L-aspartic acid, poly-L-lysine (e.g., poly-L-C.-lysine or poly-L-e-lysine), poly-L-ornithine (e.g., addition, the Sweet taste improving organic acid additives poly-L-C.-ornithine or poly-L-e-ornithine), poly-L-arginine, also may be in either the D- or L-configuration. other polymeric forms of amino acids, and salt forms thereof 0078 Suitable sweet taste improving organic acid salt (e.g., magnesium, calcium, potassium, or Sodium salts such additives include, but are not limited to, sodium, calcium, as L-glutamic acid mono Sodium salt). The Sweet taste potassium, and magnesium salts of all organic acids, such as improving polyamino acid additives also may be in the D salts of citric acid, malic acid, tartaric acid, fumaric acid, or L-configuration. Additionally, the polyamino acids may lactic acid (e.g., sodium lactate), alginic acid (e.g., sodium be Cl-, 3-, y-, 6-, and e-isomers if appropriate. Combinations alginate), ascorbic acid (e.g., sodium ascorbate), benzoic of the foregoing polyamino acids and their corresponding acid (e.g., Sodium benzoate or potassium benzoate), and salts (e.g., Sodium, potassium, calcium, magnesium salts or adipic acid. The examples of the Sweet taste improving other alkali or alkaline earth metal salts thereof or acid salts) organic acid salt additives described optionally may be also are suitable Sweet taste improving additives in embodi substituted with one or more of the following moiety ments of this invention. The polyamino acids described selected from the group consisting of hydrogen, alkyl, herein also may comprise co-polymers of different amino alkenyl, alkynyl, halo, haloalkyl, carboxyl, acyl, acyloxy, acids. The polyamino acids may be natural or synthetic. The amino, amido, carboxyl derivatives, alkylamino, dialky polyamino acids also may be modified, such that at least one lamino, arylamino, alkoxy, aryloxy, nitro, cyano, Sulfo, thiol, atom has been added, removed, Substituted, or combinations imine, Sulfonyl, Sulfenyl, Sulfinyl, Sulfamyl, carboxalkoxy, thereof (e.g., N-alkyl polyamino acid or N-acyl polyamino carboxamido, phosphonyl, phosphinyl, phosphoryl, phos acid). As used herein, polyamino acids encompass both phino, thioester, thioether, anhydride, oximino, hydrazino, modified and unmodified polyamino acids. In accordance carbamyl, phosphor phosphonato, and any other viable with particular embodiments, modified polyamino acids functional group, provided the Substituted organic acid salt include but are not limited to polyamino acids of various additive functions to improve the Sweet taste of the Sweet molecular weights (MW), such as poly-L-C-lysine with a ener composition. MW of 1,500, MW of 6,000, MW of 25,200, MW of 63,000, MW of 83,000, or MW of 300,000. 0079 Suitable sweet taste improving inorganic acid addi tives for use in embodiments of this invention include, but 0075 Suitable sweet taste improving sugar acid additives are not limited to, phosphoric acid, phosphorous acid, poly for use in embodiments of this invention include, but are not phosphoric acid, hydrochloric acid, Sulfuric acid, carbonic limited to, aldonic, uronic, aldaric, alginic, gluconic, glucu acid, Sodium dihydrogen phosphate, and their corresponding ronic, glucaric, galactaric, galacturonic, and their salts (e.g., alkali or alkaline earth metal salts thereof (e.g., inositol Sodium, potassium, calcium, magnesium salts or other hexaphosphate Mg/Ca). physiologically acceptable salts), and combinations thereof. 0080 Suitable sweet taste improving bitter compound 0.076 Suitable sweet taste improving nucleotide additives additives for use in embodiments of this invention include, for use in embodiments of this invention include, but are not but are not limited to, caffeine, quinine, urea, bitter orange limited to, inosine monophosphate (IMP), guanosine oil, naringin, quassia, and salts thereof. monophosphate (“GMP), adenosine monophosphate (AMP), cytosine monophosphate (CMP), uracil mono 0081 Suitable sweet taste improving flavorant and fla phosphate (UMP), inosine diphosphate, guanosine diphos Voring ingredient additives for use in embodiments of this phate, adenosine diphosphate, cytosine diphosphate, uracil invention include, but are not limited to, Vanillin, Vanilla diphosphate, inosine triphosphate, guanosine triphosphate, extract, mango extract, cinnamon, citrus, coconut, ginger, adenosine triphosphate, cytosine triphosphate, uracil triph viridiflorol, almond, menthol (including menthol without osphate, and their alkali or alkaline earth metal salts, and mint), grape skin extract, and grape seed extract. "Flavorant' combinations thereof. The nucleotides described herein also and “flavoring ingredient are synonymous, and include may comprise nucleotide-related additives, such as nucleo natural or synthetic Substances or combinations thereof sides or nucleic acid bases (e.g., guanine, cytosine, adenine, Flavorants also include any other substance which imparts thymine, uracil). flavor, and may include natural or non-natural (synthetic) Substances which are safe for human or animals when used 0.077 Suitable sweet taste improving organic acid addi in a generally accepted range. Non-limiting examples of tives include any compound which comprises a —COOH proprietary flavorants include DöhlerTM Natural Flavoring US 2007/01 16831 A1 May 24, 2007

Sweetness Enhancer K14323 (DöhlerTM., Darmstadt, Ger 0087 Suitable sweet taste improving astringent com many), SymriseTM Natural Flavor Mask for Sweeteners pound additives include, but are not limited to, tannic acid, 161453 and 164126 (Symrise, HolzmindenTM, Germany), europium chloride (EuCl), gadolinium chloride (GdCl3). Natural AdvantageTM Bitterness Blockers 1, 2, 9 and 10 terbium chloride (TbCl), alum, tannic acid, and polyphe (Natural AdvantageTM, Freehold. N.J., U.S.A.), and Sucra nols (e.g., tea polyphenols). maskTM (Creative Research Management, Stockton, Calif., 0088 Suitable sweet taste improving vitamins include U.S.A.). nicotinamide (Vitamin B3) and pyridoxal hydrochloride 0082 Suitable sweet taste improving polymer additives (Vitamin B6). for use in embodiments of this invention include, but are not limited to, chitosan, pectin, pectic, pectinic, polyuronic, 0089. The Sweet taste improving compositions also may polygalacturonic acid, starch, food hydrocolloid or crude comprise natural and/or synthetic high-potency Sweeteners. extracts thereof (e.g., gum acacia Senegal (FibergumTM), For example, wherein the Sweetener composition comprises gum acacia Seyal, carageenan), poly-L-lysine (e.g., poly-L- at least one NHPS, the at least one sweet taste improving C.-lysine or poly-L-e-lysine), poly-L-Omithine (e.g., poly-L- composition may comprise a synthetic high-potency Sweet C.-ornithine or poly-L-e-ornithine), polyarginine, polypropy ener, non-limiting examples of which include Sucralose, lene glycol, polyethylene glycol, poly(ethylene glycol potassium acesulfame, aspartame, alitame, Saccharin, neo methyl ether), polyaspartic acid, polyglutamic acid, poly hesperidin dihydrochalcone, cyclamate, neotame, N-N-3- ethyleneimine, alginic acid, Sodium alginate, propylene gly (3-hydroxy-4-methoxyphenyl)propyl-L-C.-aspartyl-L-phe col alginate, sodium hexametaphosphate (SHMP) and its nylalanine 1-methyl ester, N-N-3-(3-hydroxy-4- salts, and sodium polyethyleneglycolalginate and other cat methoxyphenyl)-3-methylbutyl-L-C.-aspartyl-L- ionic and anionic polymers. phenylalanine 1-methyl ester, N-N-3-(3-methoxy-4- hydroxyphenyl)propyl-L-C.-aspartyl-L-phenylalanine 0.083 Suitable sweet taste improving protein or protein 1-methyl ester, salts thereof, and the like. hydrolysate additives for use in embodiments of this inven tion include, but are not limited to, bovine serum albumin 0090 The Sweet taste improving compositions also may (BSA), whey protein (including fractions or concentrates be in Salt form which may be obtained using standard thereof such as 90% instant whey protein isolate, 34% whey procedures well known in the art. The term "salt also refers protein, 50% hydrolyzed whey protein, and 80% whey to complexes that retain the desired chemical activity of the protein concentrate), Soluble rice protein, soy protein, pro Sweet taste improving compositions of the present invention tein isolates, protein hydrolysates, reaction products of pro and are safe for human or animal consumption in a generally tein hydrolysates, glycoproteins, and/or proteoglycans con acceptable range. Alkali metal (for example, Sodium or taining amino acids (e.g., glycine, alanine, serine, threonine, potassium) or alkaline earth metal (for example, calcium or asparagine, glutamine, arginine, Valine, isoleucine, leucine, magnesium) salts also can be made. Salts also may include norvaline, methionine, proline, tyrosine, hydroxyproline, combinations of alkali and alkaline earth metals. Non and the like), collagen (e.g., gelatin), partially hydrolyzed limiting examples of Such salts are (a) acid addition salts collagen (e.g., hydrolyzed fish collagen), and collagen formed with inorganic acids and salts formed with organic hydrolysates (e.g., porcine collagen hydrolysate). acids; (b) base addition salts formed with metal cations such as calcium, bismuth, barium, magnesium, aluminum, cop 0084 Suitable sweet taste improving surfactant additives per, cobalt, nickel, cadmium, Sodium, potassium, and the for use in embodiments of this invention include, but are not like, or with a cation formed from ammonia, N,N-dibenzyl limited to, polysorbates (e.g., polyoxyethylene Sorbitan ethylenediamine, D-glucosamine, tetraethylammonium, or monooleate (polysorbate 80), polysorbate 20, polysorbate ethylenediamine; or (c) combinations of (a) and (b). Thus, 60), sodium dodecylbenzenesulfonate, dioctyl sulfosucci any salt forms which may be derived from the sweet taste nate or dioctyl Sulfo Succinate Sodium, Sodium dodecyl Sul improving compositions may be used with the embodiments fate, cetylpyridinium chloride (hexadecylpyridinium chlo of the present invention as long as the salts of the Sweet taste ride), hexadecyltrimethylammonium bromide, sodium improving additives do not adversely affect the taste of the cholate, carbamoyl, choline chloride, Sodium glycocholate, Sweetener compositions comprising the at least one natural Sodium taurodeoxycholate, lauric arginate, Sodium Stearoyl and/or synthetic high-potency Sweetener. The salt forms of lactylate, sodium taurocholate, lecithins, Sucrose oleate the additives can be added to the natural and/or synthetic esters, sucrose Stearate esters. Sucrose palmitate esters, Sweetener composition in the same amounts as their acid or Sucrose laurate esters, and other emulsifiers, and the like. base forms. 0085 Suitable sweet taste improving flavonoid additives for use in embodiments of this invention generally are 0091. In particular embodiments, suitable sweet taste classified as flavonols, flavones, flavanones, flavan-3-ols, improving inorganic salts useful as Sweet taste improving isoflavones, or anthocyanidins. Non-limiting examples of additives include, but are not limited to, sodium chloride, flavonoid additives include catechins (e.g., green tea extracts potassium chloride, Sodium sulfate, potassium citrate, such as PolyphenonTM 60, PolyphenonTM 30, and Polyphe europium chloride (EuCl), gadolinium chloride (GdCl3). nonTM 25 (Mitsui Norin Co., Ltd., Japan), polyphenols, terbium chloride (TbCls), magnesium Sulfate, alum, mag rutins (e.g., enzyme modified rutin SanmelinTM AO (San-Ei nesium chloride, mono-, di-, tri-basic sodium or potassium Gen F.F.I., Inc., Osaka, Japan)), neohesperidin, maringin, salts of phosphoric acid (e.g., inorganic phosphates), Salts of neohesperidin dihydrochalcone, and the like. hydrochloric acid (e.g., inorganic chlorides), Sodium car bonate, sodium bisulfate, and sodium bicarbonate. Further 0.086 Suitable sweet taste improving alcohol additives more, in particular embodiments, Suitable organic salts for use in embodiments of this invention include, but are not useful as Sweet taste improving additives include, but are not limited to, ethanol. limited to, choline chloride, alginic acid sodium salt (sodium US 2007/01 16831 A1 May 24, 2007 alginate), glucoheptonic acid sodium salt, gluconic acid 0.107 14. at least one natural and/or synthetic high Sodium salt (sodium gluconate), gluconic acid potassium potency Sweetener, at least one polyol, at least one amino salt (potassium gluconate), guanidine HCl, glucosamine acid, and at least one other Sweet taste improving additive; HCl, amiloride HCl, monosodium glutamate (MSG), and adenosine monophosphate salt, magnesium gluconate, 0.108 15. at least one natural and/or synthetic high potassium tartrate (monohydrate), and sodium tartrate (dihy potency Sweetener, at least one carbohydrate, at least one drate). amino acid, and at least one other Sweet taste improving 0092 C. Combinations of Sweet Taste Improving Com additive. positions 0.109 These fifteen major combinations further may be 0093. It has been discovered that combinations of at least broken down into further combinations in order to improve one natural and/or synthetic high-potency Sweetener and at the overall taste of the natural and/or synthetic high-potency least one Sweet taste improving composition improve the Sweetener or the Sweetened compositions comprising the temporal profile and/or flavor profile, including the osmotic natural and/or synthetic high-potency Sweetener. taste, to be more Sugar-like. One of ordinary skill in the art, 0110. As explained above, the Sweet taste improving with the teachings of the present invention, may arrive at all composition is selected from the group consisting of poly the possible combinations of natural and/or synthetic high ols, carbohydrates, amino acids, other Sweet taste improving potency Sweeteners and Sweet taste improving composi additives, and combinations thereof. The other Sweet taste tions. For example, non-limiting combinations of the natural improving additives useful in embodiments of this invention and/or synthetic high-potency Sweetener and Sweet taste are described hereinabove. In one embodiment, a single improving compositions include: Sweet taste improving composition may be used with a 0094) 1. at least one natural and/or synthetic high-po single natural or synthetic high-potency Sweetener and an tency Sweetener and at least one carbohydrate; active dental substance. In another embodiment of the 0.095 2. at least one natural and/or synthetic high-po present invention, a single Sweet taste improving composi tency Sweetener and at least one polyol; tion may be used with one or more natural and/or synthetic high-potency Sweeteners and an active dental Substance. In 0.096 3. at least one natural and/or synthetic high-po yet another embodiment, one or more Sweet taste improving tency Sweetener and at least one amino acid; compositions may be used with a single natural or synthetic 0097. 4. at least one natural and/or synthetic high-po high-potency sweetener and an active dental substance. In a tency Sweetener and at least one other Sweet taste improv further embodiment, there may be a plurality of Sweet taste ing additive; improving compositions used in combination with one or more natural and/or synthetic high-potency Sweeteners and 0.098 5. at least one natural and/or synthetic high-po an active dental Substance. Thus, non-limiting examples of tency Sweetener, at least one carbohydrate, at least one Sweet taste improving composition combinations for polyol, at least one amino acid, and at least one other embodiments of this invention include: Sweet taste improving additive; 0.111 i. at least one polyol, at least one carbohydrate, at 0099 6. at least one natural and/or synthetic high-po least one amino acid, and at least one other Sweet taste tency Sweetener, at least one carbohydrate, and at least improving additive; one polyol; 0112 ii. at least one polyol, at least one carbohydrate, and 0100 7. at least one natural and/or synthetic high-po at least one other Sweet taste improving additive; tency Sweetener, at least one carbohydrate, and at least one amino acid; 0113 iii. at least one polyol and at least one other sweet 0101 8. at least one natural and/or synthetic high-po taste improving additive; tency Sweetener, at least one carbohydrate, and at least 0114 iv. at least one polyol and at least one carbohydrate; one other Sweet taste improving additive; 0115 V. at least one carbohydrate and at least one other 0102) 9. at least one natural and/or synthetic high-po Sweet taste improving additive; tency Sweetener, at least one polyol, and at least one amino acid; 0116 vi. at least one polyol and at least one amino acid; 0103 10. at least one natural and/or synthetic high 0.117 vii. at least one carbohydrate and at least one amino potency Sweetener, at least one polyol, and at least one acid; other Sweet taste improving additive; 0118 viii. at least one amino acid and at least one other 0104 11. at least one natural and/or synthetic high Sweet taste improving additive. potency Sweetener, at least one amino acid, and at least Other Sweet taste improving composition combinations in one other Sweet taste improving additive; accordance with embodiments of this invention include: 0105 12. at least one natural and/or synthetic high 0119) 1. at least one polyol, at least one carbohydrate, and potency Sweetener, at least one carbohydrate, at least one at least one amino acid; polyol, and at least one amino acid; 0106 13. at least one natural and/or synthetic high 0120 2. at least one polyol, at least one carbohydrate, and potency Sweetener, at least one carbohydrate, at least one at least one polyamino acid; polyol, and at least one other Sweet taste improving 0121 3. at least one polyol, at least one carbohydrate, and additive; at least one Sugar acid; US 2007/01 16831 A1 May 24, 2007 11

0122 4. at least one polyol, at least one carbohydrate, and 0.143 25. at least one polyol, at least one carbohydrate, at least one nucleotide; and at least one polymer, and at least one other Sweet taste 0123 5. at least one polyol, at least one carbohydrate, and improving additive; at least one organic acid; 0.144, 26. at least one polyol, at least one carbohydrate, and at least one protein or protein hydrolysate, and at least 0124 6. at least one polyol, at least one carbohydrate, and one other Sweet taste improving additive; at least one inorganic acid; 0145 27. at least one polyol, at least one carbohydrate, 0125 7. at least one polyol, at least one carbohydrate, and and at least one Surfactant, and at least one other Sweet at least one bitter compound; taste improving additive; 0126 8. at least one polyol, at least one carbohydrate, and 0146 28. at least one polyol, at least one carbohydrate, at least one flavorant or flavoring ingredient; and at least one flavonoid, and at least one other Sweet 0127 9. at least one polyol, at least one carbohydrate, and taste improving additive; at least one polymer; 0147 29. at least one polyol, at least one carbohydrate, 0128 10. at least one polyol, at least one carbohydrate, and at least one alcohol, and at least one other Sweet taste and at least one protein or protein hydrolysate or protein improving additive; or protein hydrolysate with low molecular weight amino 0.148 30. at least one polyol, at least one carbohydrate, at acid; least one amino acid, and at least one polyamino acid; 0129 11. at least one polyol, at least one carbohydrate, 0.149 31. at least one polyol, at least one carbohydrate, at and at least one surfactant; least one amino acid, at least one polyamino acid, and at 0130 12. at least one polyol. at least one carbohydrate, least one Sugar acid; and at least one flavonoid; 0.150 32. at least one polyol, at least one carbohydrate, at least one amino acid, at least one polyamino acid, at least 0131) 13. at least one polyol. at least one carbohydrate, one Sugar acid, and at least one nucleotide; and at least one alcohol; 0151. 33. at least one polyol, at least one carbohydrate, at 0132) 14. at least one polyol. at least one carbohydrate, least one amino acid, at least one polyamino acid, at least and at least one emulsifier; one Sugar acid, at least one nucleotide, and at least one 0.133 15. at least one polyol, at least one carbohydrate, organic acid; and at least one inorganic salt, 0152 34. at least one polyol, at least one carbohydrate, at least one amino acid, at least one polyamino acid, at least 0134 16. at least one polyol, at least one carbohydrate, one Sugar acid, at least one nucleotide, at least one organic and at least one organic salt, acid, and at least one inorganic acid; 0135) 17. at least one polyol, at least one carbohydrate, 0153. 35. at least one polyol, at least one carbohydrate, at and at least one amino acid, and at least one other Sweet least one amino acid, at least one polyanino acid, at least taste improving additive; one Sugar acid, at least one nucleotide, at least one organic 0136. 18. at least one polyol, at least one carbohydrate, acid, at least one inorganic acid, and at least one bitter and at least one polyamino acid, and at least one other compound; Sweet taste improving additive; 0154 36. at least one polyol, at least one carbohydrate, at 0137) 19. at least one polyol, at least one carbohydrate, least one amino acid, at least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic and at least one Sugar acid, and at least one other Sweet acid, at least one inorganic acid, at least one bitter taste improving additive; compound, and at least one polymer, 0138 20. at least one polyol, at least one carbohydrate, 0.155 37. at least one polyol, at least one carbohydrate, at and at least one nucleotide, and at least one other Sweet least one amino acid, at least one polyamino acid, at least taste improving additive; one Sugar acid, at least one nucleotide, at least one organic 0139 21. at least one polyol, at least one carbohydrate, acid, at least one inorganic acid, at least one bitter and at least one organic acid, and at least one other Sweet compound, at least one polymer, and at least one protein taste improving additive; or protein hydrolysate; 0140 22. at least one polyol, at least one carbohydrate, 0156) 38. at least one polyol, at least one carbohydrate, at and at least one inorganic acid, and at least one other least one amino acid, at least one polyamino acid, at least Sweet taste improving additive; one Sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter 0141 23. at least one polyol, at least one carbohydrate, compound, at least one polymer, at least one protein or and at least one bitter compound, and at least one other protein hydrolysate, and at least one Surfactant; Sweet taste improving additive; 0157 39. at least one polyol, at least one carbohydrate, at 0142 24. at least one polyol, at least one carbohydrate, least one amino acid, at least one polyamino acid, at least and at least one flavorant or flavoring ingredient, and at one Sugar acid, at least one nucleotide, at least one organic least one other Sweet taste improving additive; acid, at least one inorganic acid, at least one bitter US 2007/01 16831 A1 May 24, 2007

compound, at least one polymer, at least one protein or 0.179 61. at least one polyol, at least one carbohydrate, at protein hydrolysate, at least one Surfactant, and at least least one Sugar acid, and at least one nucleotide; one flavonoid; 0180) 62. at least one polyol, at least one carbohydrate, at 0158 40. at least one polyol, at least one carbohydrate, at least one Sugar acid, and at least one organic acid; least one amino acid, at least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic 0181 63. at least one polyol, at least one carbohydrate, at acid, at least one inorganic acid, at least one bitter least one Sugar acid, and at least one inorganic acid; compound, at least one polymer, at least one protein or 0.182) 64. at least one polyol, at least one carbohydrate, at protein hydrolysate, at least one Surfactant, at least one least one Sugar acid, and at least one bitter compound; flavonoid, and at least one alcohol; 0183 65. at least one polyol, at least one carbohydrate, at 0159. 41. at least one polyol, at least one carbohydrate, at least one Sugar acid, and at least one polymer; least one amino acid, and at least one Sugar acid; 0.184 66. at least one polyol, at least one carbohydrate, at 0160 42. at least one polyol, at least one carbohydrate, at least one Sugar acid, and at least one protein or protein least one amino acid, and at least one nucleotide; hydrolysate; 0161 43. at least one polyol, at least one carbohydrate, at 0185. 67. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one organic acid; least one Sugar acid, and at least one surfactant; 0162 44. at least one polyol, at least one carbohydrate, at 0186 68. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one inorganic acid; least one Sugar acid, and at least one flavonoid; 0163 45. at least one polyol, at least one carbohydrate, at 0187. 69. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one bitter compound; least one Sugar acid, and at least one alcohol; 0164. 46. at least one polyol, at least one carbohydrate, at 0188 70. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one polymer; least one nucleotide, and at least one organic acid; 0165 47. at least one polyol, at least one carbohydrate, at 0189 71. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one protein or protein hydrolysate; least one nucleotide, and at least one inorganic acid; 0166 48. at least one polyol, at least one carbohydrate, at 0.190) 72. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one Surfactant; least one nucleotide, and at least one bitter compound; 0167 49. at least one polyol, at least one carbohydrate, at 0191) 73. at least one polyol, at least one carbohydrate, at least one amino acid, and at least one flavonoid; least one nucleotide, and at least one polymer; 0.192 74. at least one polyol, at least one carbohydrate, at 0168 50. at least one polyol, at least one carbohydrate, at least one nucleotide, and at least one protein or protein least one amino acid, and at least one alcohol; hydrolysate; 0169 51. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one Sugar acid; 0193 75. at least one polyol, at least one carbohydrate, at least one nucleotide, and at least one surfactant; 0170 52. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one nucleotide; 0194 76. at least one polyol, at least one carhohydrate, at least one nucleotide, and at least one flavonoid; 0171 53. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one organic acid; 0.195 77. at least one polyol, at least one carbohydrate, at least one nucleotide, and at least one alcohol; 0172 54. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one inorganic acid; 0196) 78. at least one polyol, at least one carbohydrate, at least one organic acid, and at least one inorganic acid; 0173 55. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one bitter com 0.197 79. at least one polyol, at least one carbohydrate, at pound; least one organic acid, and at least one bitter compound; 0174 56. at least one polyol, at least one carbohydrate, at 0198 80. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one polymer; least one organic acid, and at least one polymer, 0175 57. at least one polyol, at least one carbohydrate, at 0199 81. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one protein or least one organic acid, and at least one protein or protein protein hydrolysate; hydrolysate; 0176) 58. at least one polyol, at least one carbohydrate, at 0200 82. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one surfactant; least one organic acid, and at least one surfactant; 0177 59. at least one polyol, at least one carbohydrate, at 0201 83. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one flavonoid; least one organic acid, and at least one flavonoid; 0178) 60. at least one polyol, at least one carbohydrate, at 0202) 84. at least one polyol, at least one carbohydrate, at least one polyamino acid, and at least one alcohol; least one organic acid, and at least one alcohol; US 2007/01 16831 A1 May 24, 2007

0203 85. at least one polyol, at least one carbohydrate, at 0227 5. at least one polyol and at least one organic acid; least one inorganic acid, and at least one bitter compound; 0228 6. at least one polyol and at least one inorganic 0204 86. at least one polyol, at least one carbohydrate, at acid; least one inorganic acid, and at least one polymer. 0229 7. at least one polyol and at least one bitter com 0205 87. at least one polyol, at least one carbohydrate, at pound; least one inorganic acid, and at least one protein or protein 0230 8. at least one polyol and at least one flavorant or hydrolysate; flavoring ingredient; 0206 88. at least one polyol, at least one carbohydrate, at least one inorganic acid, and at least one Surfactant; 0231. 9. at least one polyol and at least one polymer; 0232 10. at least one polypolvol and at least one pprotein or 0207 89. at least one polyol, at least one carbohydrate, at protein hydrolysate; least one inorganic acid, and at least one flavonoid; 0208 90. at least one polyol, at least one carbohydrate, at 0233) 11. at least one polyol and at least one surfactant; least one inorganic acid, and at least one alcohol; 0234 12. at least one polyol and at least one flavonoid; 0209) 91. at least one polyol, at least one carbohydrate, at 0235 13. at least one polyol and at least one alcohol; least one bitter compound, and at least one polymer; 0236) 14. at least one polyol and at least one emulsifier; 0210 92. at least one polyol, at least one carbohydrate, at least one bitter compound, and at least one protein or 0237) 15. at least one polyol and at least one inorganic protein hydrolysate; salt; 0211 93. at least one polyol, at least one carbohydrate, at 0238 16. at least one polyol and at least one organic salt; least one bitter compound, and at least one Surfactant; 0239) 17. at least one polyol and at least one protein or 0212 94. at least one polyol, at least one carbohydrate, at protein hydrolysate or mixture of low molecular weight least one bitter compound, and at least one flavonoid; amino acids; 0213 95. at least one polyol, at least one carbohydrate, at 0240 18. at least one polyol, at least one amino acid, and least one bitter compound, and at least one alcohol; at least one other Sweet taste improving additive. 0214) 96. at least one polyol, at least one carbohydrate, at 0241) 19. at least one polyol, at least one polyamino acid, least one polymer, and at least one protein or protein and at least one other Sweet taste improving additive; hydrolysate; 0242 20. at least one polyol, at least one Sugar acid, and 0215 97. at least one polyol, at least one carbohydrate, at at least one other Sweet taste improving additive; least one polymer, and at least one Surfactant; 0243 21. at least one polyol, at least one nucleotide, and 0216) 98. at least one polyol, at least one carbohydrate, at at least one other Sweet taste improving additive; least one polymer, and at least one flavonoid; 0244, 22. at least one polyol, at least one organic acid, 0217. 99. at least one polyol, at least one carbohydrate, at and at least one other Sweet taste improving additive; least one polymer, and at least one alcohol; 0245 23. at least one polyol, at least one inorganic acid, 0218 100. at least one polyol, at least one carbohydrate, and at least one other Sweet taste improving additive; at least one protein or protein hydrolysate, and at least one 0246 24. at least one polyol, at least one bitter com Surfactant; pound, and at least one other Sweet taste improving 0219 101. at least one polyol, at least one carbohydrate, additive; at least one protein or protein hydrolysate, and at least one 0247 25. at least one polyol, at least one flavorant or flavonoid; flavoring ingredient, and at least one other Sweet taste 0220 102. at least one polyol, at least one carbohydrate, improving additive; at least one surfactant, and at least one flavonoid; 0248 26. at least one polyol, at least one polymer, and at 0221 103. at least one polyol, at least one carbohydrate, least one other Sweet taste improving additive; at least one surfactant, and at least one alcohol; and O249 27 ... at 1least one polyolpolyol, at 1least one proteiprotein or 0222 104. at least one polyol, at least one carbohydrates protein hydrolysate, and at least one other Sweet taste at least one flavonoid, and at least one alcohol. improving additive; Other Sweet taste improving composition combinations in 0250) 28. at least one polyol, at least one surfactant, and accordance with embodiments of this invention include: at least one other Sweet taste improving additive; 0251 29. at least one polyol, at least one flavonoid, and 0223 1. at least one polyol and at least one amino acid; at least one other Sweet taste improving additive; 0224 2. at least one polyol and at least one polyamino 0252 30. at least one polyol, at least one alcohol, and at acid; least one other Sweet taste improving additive; 0225 3. at least one polyol and at least one sugar acid; 0253 31. at least one polyol, at least one amino acid, and 0226 4. at least one polyol and at least one nucleotide; at least one polyamino acid; US 2007/01 16831 A1 May 24, 2007

0254 32. at least one polyol, at least one amino acid, at 0270 48. at least one polyol, at least one amino acid, and least one polyamino acid, and at least one Sugar acid; at least one protein or protein hydrolysate; 0255 33. at least one polyol, at least one amino acid, at 0271 49. at least one polyol, at least one amino acid, and least one polyamino acid, at least one Sugar acid, and at at least one surfactant; least one nucleotide; 0272 50. at least one polyol, at least one amino acid, and 0256 34. at least one polyol, at least one amino acid, at at least one flavonoid; least one polyamino acid, at least one Sugar acid, at least 0273 51. at least one polyol, at least one amino acid, and one nucleotide, and at least one organic acid; at least one alcohol; 0257 35. at least one polyol, at least one amino acid, at least one polyamino acid, at least one Sugar acid, at least 0274 52. at least one polyol, at least one polyamino acid, one nucleotide, at least one organic acid, and at least one and at least one Sugar acid; inorganic acid; 0275 53. at least one polyol, at least one polyamino acid, 0258 36. at least one polyol, at least one amino acid, at and at least one nucleotide; least one polyamino acid, at least one Sugar acid, at least 0276 54. at least one polyol, at least one polyamino acid, one nucleotide, at least one organic acid, at least one and at least one organic acid; inorganic acid, and at least one bitter compound; 0277 55. at least one polyol, at least one polyamino acid, 0259 37. at least one polyol, at least one amino acid, at and at least one organic salt; least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic acid, at least one 0278) 56. at least one polyol, at least one polyamino acid, inorganic acid, at least one bitter compound, and at least and at least one inorganic acid; one polymer; 0279 57. at least one polyol, at least one polyamino acid, 0260 38. at least one polyol, at least one amino acid, at and at least one inorganic salt; least one polyamino acid, at least one Sugar acid, at least 0280 58. at least one polyol, at least one polyamino acid, one nucleotide, at least one organic acid, at least one and at least one bitter compound; inorganic acid, at least one bitter compound, at least one 0281 59. at least one polyol, at least one polyamino acid, polymer, and at least one protein or protein hydrolysate; and at least one polymer; 0261 39. at least one polyol, at least one amino acid, at least one polyamino acid, at least one Sugar acid, at least 0282) 60. at least one polyol, at least one polyamino acid, one nucleotide, at least one organic acid, at least one and at least one protein or protein hydrolysate; inorganic acid, at least one bitter compound, at least one 0283 61. at least one polyol, at least one polyamino acid, polymer, at least one protein or protein hydrolysate, and and at least one Surfactant; at least one surfactant; 0284) 62. at least one polyol, at least one polyamino acid, 0262 40. at least one polyol, at least one amino acid, at and at least one flavonoid; least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic acid, at least one 0285 63. at least one polyol, at least one polyamino acid, inorganic acid, at least one bitter compound, at least one and at least one alcohol; polymer, at least one protein or protein hydrolysate, at 0286 64. at least one polyol, at least one Sugar acid, and least one surfactant, and at least one flavonoid; at least one nucleotide; 0263 41. at least one polyol, at least one amino acid, at 0287 65. at least one polyol, at least one sugar acid, and least one polyamino acid, at least one Sugar acid, at least at least one organic acid; one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one 0288 66. at least one polyol, at least one sugar acid, and polymer, at least one protein or protein hydrolysate, at at least one inorganic acid; least one Surfactant, at least one flavonoid, and at least one 0289 67. at least one polyol, at least one sugar acid, and alcohol; at least one bitter compound; 0264. 42. at least one polyol, at least one amino acid, and 0290 68. at least one polyol, at least one sugar acid, and at least one Sugar acid; at least one polymer, 0265 43. at least one polyol, at least one amino acid, and 0291 69. at least one polyol, at least one sugar acid, and at least one nucleotide; at least one protein or protein hydrolysate; 0266 44. at least one polyol, at least one amino acid, and 0292 70. at least one polyol, at least one sugar acid, and at least one organic acid; at least one surfactant; 0267 45. at least one polyol, at least one amino acid, and 0293 71. at least one polyol, at least one sugar acid, and at least one inorganic acid; at least one flavonoid; 0268 46. at least one polyol, at least one amino acid, and 0294 72. at least one polyol, at least one sugar acid, and at least one bitter compound; at least one alcohol; 0269 47. at least one polyol, at least one amino acid, and 0295) 73. at least one polyol, at least one nucleotide, and at least one polymer; at least one organic acid; US 2007/01 16831 A1 May 24, 2007 15

0296) 74. at least one polyol, at least one nucleotide, and 0322 100. at least one polyol, at least one polymer, and at least one inorganic acid; at least one surfactant; 0297 75. at least one polyol, at least one nucleotide, and 0323 101. at least one polyol, at least one polymer, and at least one bitter compound; at least one flavonoid; 0298 76. at least one polyol, at least one nucleotide, and 0324 102. at least one polyol, at least one polymer, and at least one polymer; at least one alcohol; 0299 77. at least one polyol, at least one nucleotide, and 0325 103. at least one polyol, at least one protein or at least one protein or protein hydrolysate; protein hydrolysate, and at least one Surfactant; 0300 78. at least one polyol, at least one nucleotide, and 0326 104. at least one polyol, at least one protein or at least one surfactant; protein hydrolysate, and at least one flavonoid; 0301 79. at least one polyol, at least one nueleotide, and 0327 105. at least one polyol, at least one surfactant, and at least one flavonoid; at least one flavonoid; 0302) 80. at least one polyol, at least one nucleotide, and 0328. 106. at least one polyol, at least one surfactant, and at least one alcohol; at least one alcohol; 0303 81. at least one polyol, at least one organic acid, 0329 107. at least one polyol, at least one flavonoid, and and at least one inorganic acid; at least one alcohol; 0304 82. at least one polyol, at least one organic acid, 0330 108. at least one sweet taste improving additive and and at least one bitter compound; erythritol; 0305 83. at least one polyol, at least one organic acid, 0331 109. at least one sweet taste improving additive and and at least one polymer; maltitol; 0306 84. at least one polyol, at least one organic acid, 0332 110. at least one sweet taste improving additive and and at least one protein or protein hydrolysate; mannitol; 0307 85. at least one polyol, at least one organic acid, 0333 111. at least one sweet taste improving additive and and at least one surfactant; sorbitol; 0308) 86. at least one polyol, at least one organic acid, 0334 112. at least one sweet taste improving additive and and at least one flavonoid; lactitol; 0309 87. at least one polyol, at least one organic acid, 0335) 113. at least one sweet taste improving additive and and at least one alcohol; xylitol; 0310 88. at least one polyol, at least one inorganic acid, 0336 114. at least one sweet taste improving additive and and at least one bitter compound; isomalt, 0311. 89. at least one polyol, at least one inorganic acid, 0337 115. at least one sweet taste improving additive and and at least one polymer; propylene glycol; 0312 90. at least one polyol, at least one inorganic acid, 0338 116. at least one sweet taste improving additive and and at least one protein or protein hydrolysate; glycerol; 0313 91. at least one polyol, at least one inorganic acid, 0339) 117. at least one sweet taste improving additive and and at least one surfactant; palatinose; 0314 92. at least one polyol, at least one inorganic acid, 0340 118. at least one sweet taste improving additive and and at least one flavonoid; reduced isomalto-oligosaccharides; 0315 93. at least one polyol, at least one inorganic acid, 0341 119. at least one sweet taste improving additive and and at least one alcohol; reduced Xylo-oligosaccharides; 0316) 94. at least one polyol, at least one bitter com 0342 120. at least one sweet taste improving additive and pound, and at least one polymer; reduced gentio-oligosaccharides; O317 95 ... at 1least one polyolpolyol, at 1least one bib1tter com 0343) 121. at least one sweet taste improving additive and pound, and at least one protein or protein hydrolysate; reduced maltose syrup; O318 96 ... at 1least one polyol,polyol at 1least one bib1tter com 0344) 122. at least one sweet taste improving additive and pound, and at least one surfactant; reduced glucose syrup; O319 97 ... at 1least one polyolpolyol, at 1least one bib1tter com 0345 123. at least one sweet taste improving additive, pound, and at least one flavonoid; erythritol, and at least one other polyol; 0320 98. at least one polyol, at least one bitter com 0346 124. at least one sweet taste improving additive, pound, and at least one alcohol; maltitol, and at least one other polyol; 0321 99. at least one polyol, at least one polymer, and at 0347 125. at least one sweet taste improving additive, least one protein or protein hydrolysate; mannitol, and at least one other polyol; US 2007/01 16831 A1 May 24, 2007 16

0348 126. at least one sweet taste improving additive, 0379) 2O. at least one polyol and idose; Sorbitol, and at least one other polyol; 0380) 21. at least one polyol and talose; 0349 127. at least one sweet taste improving additive, lactitol, and at least one other polyol; 0381 22. at least one polyol and lactose; 0350 128. at least one sweet taste improving additive, 0382) 23. at least one polyol and maltose; Xylitol, and at least one other polyol; 0383) 24. at least one polyol and invert Sugar, 0351 129. at least one sweet taste improving additive, 0384) 25. at least one polyol and trehalose; isomalt, and at least one other polyol; 0385) 26. at least one polyol and isotrebalose; 0352 130. at least one sweet taste improving additive, propylene glycol, and at least one other polyol; 0386 27. at least one polyol and neotrehalose; 0353 131. at least one sweet taste improving additive, 0387) 28. at least one polyol and palatinose; glycerol, and at least one other polyol; 0388 29. at least one polyol and galaclose; 0354 132. at least one sweet taste improving additive, 0389) 3O. at least one polyol and beet oligosaccharides; palatinose, and at least one other polyol; 0390) 31. at least one polyol and isomalto-oligosaccha 0355 133. at least one sweet taste improving additive, rides; reduced isomalto-oligosaccharides, and at least one other polyol; 0391) 32. at least one polyol and isomaltose; 0356) 134. at least one sweet taste improving additive, 0392) 33. at least one polyol and isomaltotriose; reduced Xylo-oligosaccharides, and at least one other 0393) 34. at least one polyol and panose; polyol; 0394) 35. at least one polyol and Xylo-oligosaccharides; 0357 135. at least one sweet taste improving additive, reduced gentio-oligosaccharides, and at least one other 0395) 36. at least one polyol and Xylotriose; polyol; 0396) 37. at least one polyol and Xylobiose; 0358) 136. at least one sweet taste improving additive, 0397) 38. at least one polyol and gentio-oligoscaccha reduced maltose syrup, and at least one other polyol; and rides; 0359 137. at least one sweet taste improving additive, 0398 39. at least one polyol and gentiobiose; reduced glucose syrup, and at least one other polyol. 0399) 40. at least one polyol and gentiotriose; Other Sweet taste improving composition combinations in 41. accordance with embodiments of this invention include: 04.00 at least one polyol and gentiotetraose; 0360) 1. at least one polyol and tagatose; 0401) 42. at least one polyol and Sorbose; 0361) 2. at least one polyol and trehalose; 0402 43. at least one polyol and nigero-oligosaccharides; 0403) 44. at least one polyol and palatinose oligosaccha 0362. 3. at least one polyol and galactose; rides; 0363 4. at least one polyol and rhamnose; 04.04 45. at least one polyol and fucose: 0364 5. at least one polyol and dextrin; 0405 46. at least one polyol and fructooligosaccharides; 0365 6. at least one polyol and cyclodextrin; 0406) 47. at least one polyol and kestose; 0366 7. at least one polyol and C-cyclodextrin, B-cyclo dextrin, or Y-cyclodextrin; 0407 48. at least one polyol and nystose; 0367 8. at least one polyol and maltodextrin; 04.08 49. at least one polyol and maltotetraol; 0368 9. at least one polyol and dextran; 04.09 50. at least one polyol and maltotriol: 0369 10. at least one polyol and sucrose; 0410 51. at least one polyol and malto-oligosaccharides; 0370 1 1. at least one polyol and glucose: 0411 52. at least one polyol and maltotriose; 0371) 12. at least one polyol and fructose; 0412 53. at least one polyol and maltotetraose; 0372 13. at least one polyol and threose; 0413 54. at least one polyol and maltopentaose; 0373 14. at least one polyol and arabinose; 0414 55. at least one polyol and maltohexaose; 0374 15. at least one polyol and xylose; 0415) 56. at least one polyol and maltoheptaose; 0375 16. at least one polyol and lyxose; 0416) 57. at least one polyol and lactulose; 0376) 17. at least one polyol and allose; 0417 58. at least one polyol and melibiose; 0377 18. at least one polyol and altrose; 0418) 59. at least one polyol and raffinose; 0378 19. at least one polyol and mannose; 0419 6O. at least one polyol and rhamnose; US 2007/01 16831 A1 May 24, 2007

0420 61. at least one polyol and ribose; 0447 88. at least one polyol, lactose, and at least one 0421) 62. at least one polyol and isomerized liquid Sug other carbohydrate; arS., 0448 89. at least one polyol, maltose, and at least one 0422 63. at least one polyol and high fructose corn syrup other carbohydrate; (e.g. HFCS55 and HFCS42) or starch syrup; 0449 90. at least one polyol, invert sugar, and at least one 0423 64. at least one polyol and coupling Sugars; other carbohydrate; 0450 91. at least one polyol, trehalose, and at least one 0424 65. at least one polyol and soybean oligosaccha other carbohydrate; rides; 0451 92. at least one polyol, isotrehalose, and at least one 0425 66. at least one polyol and glucose syrup; other carbohydrate; 0426 67. at least one polyol, tagatose, and at least one 0452 93. at least one polyol, neotrehalose, and at least other carbohydrate; one other carbohydrate; 0427 68. at least one polyol, trebalose, and at least one 0453 94. at least one polyol, palatinose, and at least one other carbohydrate; other carbohydrate; 0428 69. at least one polyol, galactose, and at least one 0454. 95. at least one polyol, galactose, and at least one other carbohydrate; other carbohydrate; 0429 70. at least one polyol, rhamnose, and at least one 0455 96. at least one polyol, beet oligosaccharides, and other carbohydrate; at least one other carbohydrate; 0430) 71. at least one polyol, dextrin, and at least one 0456 97. at least one polyol, isomalto-oligosaccharides, other carbohydrate; and at least one other carbohydrate; 0431 72. at least one polyol, cyclodextrin, and at least 0457 98. at least one polyol, isomaltose, and at least one one other carbohydrate; other carbohydrate; 0432 73. at least one polyol, B-cyclodextrin, and at least 0458 99. at least one polyol, isomaltotriose, and at least one other carbohydrate; one other carbohydrate; 0433 74. at least one polyol, maltodextrin, and at least 0459 100. at least one polyol, panose, and at least one one other carbohydrate; other carbohydrate; 0434 75. at least one polyol, dextran, and at least one 0460 101. at least one polyol, xylo-oligosaccharides, and other carbohydrate; at least one other carbohydrate; 0435 76. at least one polyol, sucrose, and at least one 0461) 102. at least one polyol. Xylotriose, and at least one other carbohydrate; other carbohydrate; 0436 77. at least one polyol, glucose, and at least one 0462) 103. at least one polyol, xylobiose, and at least one other carbohydrate; other carbohydrate; 0437 78. at least one polyol, fructose, and at least one 0463. 104. at least one polyol, gentio-oligoscaccharides, other carbohydrate; and at least one other carbohydrate; 0438 79. at least one polyol, threose, and at least one 0464) 105. at least one polyol, gentiobiose, and at least other carbohydrate; one other carbohydrate; 0439 80. at least one polyol, arabinose, and at least one 0465. 106. at least one polyol, gentiotriose, and at least other carbohydrate; one other carbohydrate; 0440 81. at least one polyol, xylose, and at least one 0466 107. at least one polyol, gentiotetraose, and at least other carbohydrate; one other carbohydrate; 0441 82. at least one polyol, lyxose, and at least one 0467 108. at least one polyol, Sorbose, and at least one other carbohydrate; other carbohydrate; 0442 83. at least one polyol, allose, and at least one other 0468 109. at least one polyol, nigero-oligosaccharides, carbohydrate; and at least one other carbohydrate; 0443 84. at least one polyol, altrose, and at least one 0469 110. at least one polyol, palatinose oligosaccha other carbohydrate; rides, and at least one other carbohydrate; 0444 85. at least one polyol, mannose, and at least one 0470 111. at least one polyol, fucose, and at least one other carbohydrate; other carbohydrate; 0445 86. at least one polyol, idose, and at least one other 0471) 112. at least one polyol, fructooligosaccharides, carbohydrate; and at least one other carbohydrate; 0446 87. at least one polyol, talose, and at least one other 0472. 113. at least one polyol, kestose, and at least one carbohydrate; other carbohydrate; US 2007/01 16831 A1 May 24, 2007

0473 114. at least one polyol, nystose, and at least one 0502. 143. at least one carbohydrate and reduced isoma other carbohydrate; lto-oligosaccharides; 0474 115. at least one polyol, maltotetraol, and at least 0503) 144. at least one carbohydrate and reduced xylo one other carbohydrate; oligosaccharides; 0475) 116. at least one polyol, maltotriol, and at least one 0504 145. at least one carbohydrate and reduced gentio other carbohydrate; oligosaccharides; 0476) 117. at least one polyol, malto-oligosaccharides, 0505) 146. at least one carbohydrate and reduced maltose and at least one other carbohydrate; syrup; 0477 118. at least one polyol, maltotriose, and at least 0506) 147. at least one carbohydrate and reduced glucose one other carbohydrate; syrup; 0478 119. at least one polyol, maltotetraose, and at least 0507 148. at least one carbohydrate, erythritol, and at one other carbohydrate; least one other polyol; 0479 120. at least one polyol, mallopentaose, and at least 0508) 149. at least one carbohydrate, maltitol, and at least one other carbohydrate; one other polyol; 0480 121. at least one polyol, maltohexaose, and at least 0509 150. at least one carbohydrate, mannitol, and at one other carbohydrate; least one other polyol; 0481 122. at least one polyol, maltoheptaose, and at least 0510) 151. at least one carbohydrate, sorbitol, and at least one other carbohydrate; one other polyol; 0482 123. at least one polyol, lactulose, and at least one 0511 152. at least one carbohydrate, lactitol, and at least other carbohydrate; one other polyol; 0483) 124. at least one polyol, melibiose, and at least one 0512 153. at least one carbohydrate, xylitol, and at least other carbohydrate; one other polyol; 0484 125. at least one polyol, raffinose, and at least one 0513 154. at least one carbohydrate, isoimalt, and at least other carbohydrate; one other polyol; 0485 126. at least one polyol, rhamnose, and at least one 0514 155. at least one carbohydrate, propylene glycol, other carbohydrate; and at least one other polyol; 0486 127. at least one polyol, ribose, and at least one 0515 156. at least one carbohydrate, glycerol, and at other carbohydrate; least one other polyol; 0487. 128. at least one polyol, isomerized liquid sugars, 0516) 157. at least one carbohydrate, palatinose, and at and at least one other carbohydrate; least one other polyol; 0488 129. at least one polyol, high fructose corn syrup 0517 158. at least one carbohydrate, reduced isomalto (e.g. HFCS55 and HFCS42) or starch syrup, and at least oligosaccharides, and at least one other polyol; one other carbohydrate; 0518) 159. at least one carbohydrate, reduced xylo-oli 0489 130. at least one polyol, coupling sugars, and at gosaccharides, and at least one other polyol; least one other carbohydrate; 0519) 160, at least one carbohydrate, reduced gentio 0490 13 1. at least one polyol, soybean oligosaccharides, oligosaccharides, and at least one other polyol; and at least one other carbohydrate; 0520 161. at least one carbohydrate, reduced maltose 0491) 132. at least one polyol, glucose syrup, and at least syrup, and at least one other polyol; and one other carbohydrate; 0521. 162. at least one carbohydrate, reduced glucose 0492) 133. at least one carbohydrate and erythritol; syrup, and at least one other polyol. 0493 134. at least one carbohydrate and maltitol; Other Sweet taste improving composition combinations in accordance with embodiments of this invention include: 0494 135. at least one carbohydrate and mannitol; 0522) 1. at least one carbohydrate and at least one amino 0495) 136. at least one carbohydrate and sorbitol; acid; 0496 137. at least one carbohydrate and lactitol; 0523 2. at least one carbohydrate and at least one 0497 138. at least one carbohydrate and xylitol; polyamino acid; 0524) 3. at least one carbohydrate and at least one sugar 0498 139. at least one carbohydrate and isomalt; acid; 0499) 140. at least one carbohydrate and propylene gly 0525 4. at least one carbohydrate and at least one nucle col; otide; 0500 141. at least one carbohydrate and glycerol: 0526 5. at least one carbohydrate and at least one organic 0501) 142. at least one carbohydrate and palatinose; acid; US 2007/01 16831 A1 May 24, 2007

0527 6. at least one carbohydrate and at least one inor 0550 29. at least one carbohydrate, at least one alcohol, ganic acid; and at least one other Sweet taste improving additive; 0528 7. at least one carbohydrate and at least one bitter 0551 3.0. at least one carbohydrate, at least one amino compound; acid, and at least one polyamino acid; 0529) 8. at least one carbohydrate and at least one fla 0552) 31. at least one carbohydrate, at least one amino Vorant or flavoring ingredient; acid, at least one polyamino acid, and at least one Sugar 0530 9. at least one carbohydrate and at least one poly acid; mer, 0553 32. at least one carbohydrate, at least one amino 0531 10. at least one carbohydrate and at least one acid, at least one polyamino acid, at least one Sugar acid, protein or protein hydrolvsate; and at least one nucleotide; 0554 33. at least one carbohydrate, at least one amino 0532) 11. at least one carbohydrate and at least one acid, at least one polyamino acid, at least one Sugar acid, Surfactant; at least one nucleotide, and at least one organic acid; 0533 12. at least one carbohydrate and at least one 0555 34. at least one carbohydrate, at least one amino flavonoid; acid, at least one polyamino acid, at least one Sugar acid, 0534 13. at least one carbohydrate and at least one at least one nucleotide, at least one organic acid, and at alcohol; least one inorganic acid; 0535 14. at least one carbohydrate and at least one 0556) 35. at least one carbohydrate, at least one amino protein or protein hydrolysate or mixture of low molecu acid, at least one polyamino acid, at least one Sugar acid, lar weight amino acids; at least one nucleotide, at least one organic acid, at least 0536) 15. at least one carbohydrate and at least one one inorganic acid, and at least one bitter compound; emulsifier; 0557. 36. at least one carbohydrate, at least one amino 0537) 16. at least one carbohydrate and at least one acid, at least one polyamino acid, at least one Sugar acid, inorganic salt, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, and at 0538 17. at least one carbohydrate, at least one amino least one polymer; acid, and at least one other Sweet taste improving additive; 0558 37. at least one carbohydrate, at least one amino 0539 18. at least one carbohydrate, at least one acid, at least one polyamino acid, at least one Sugar acid, polyamino acid, and at least one other Sweet taste improv at least one nucleotide, at least one organic acid, at least ing additive; one inorganic acid, at least one bitter compound, at least 0540 19. at least one carbohydrate, at least one sugar one polymer, and at least one protein or protein hydroly acid, and at least one other Sweet taste improving additive; Sate: 0541. 20. at least one carbohydrate, at least one nucle 0559) 38. at least one carbohydrate, at least one amino otide, and at least one other Sweet taste improving addi acid, at least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic acid, at least tive; one inorganic acid, at least one bitter compound, at least 0542. 21. at least one carbohydrate, at least one organic one polymer, at least one protein or protein hydrolysate, acid, and at least one other Sweet taste improving additive; and at least one Surfactant; 0543. 22. at least one carbohydrate, at least one inorganic 0560 39. at least one carbohydrate, at least one amino acid, and at least one other Sweet taste improving additive; acid, at least one polyamino acid, at least one Sugar acid, at least one nucleotide, at least one organic acid, at least 0544, 23. at least one carbohydrate, at least one bitter one inorganic acid, at least one bitter compound, at least compound, and at least one other Sweet taste improving one polymer, at least one protein or protein hydrolysate, additive; at least one surfactant, and at least one flavonoid; 0545 24. at least one carbohydrate, at least one flavorant 0561 40. at least one carbohydrate, at least one amino or flavoring ingredient, and at least one other Sweet taste acid, at least one polyamino acid, at least one Sugar acid, improving additive; at least one nucleotide, at least one organic acid, at least 0546 25. at least one carbohydrate, at least one polymer, one inorganic acid, at least one bitter compound, at least and at least one other Sweet taste improving additive; one polymer, at least one protein or protein hydrolysate, 0547. 26. at least one carbohydrate, at least one protein or at least one surfactant, at least one flavonoid, and at least protein hydrolysate, and at least one other Sweet taste one alcohol; improving additive; 0562 41. at least one carbohydrate, at least one amino 0548. 27. at least one carbohydrate, at least one surfac acid, and at least one Sugar acid; tant, and at least one other Sweet taste improving additive; 0563 42. at least one carbohydrate, at least one amino 0549. 28. at least one carbohydrate, at least one fla acid, and at least one nucleotide; vonoid, and at least one other Sweet taste improving 0564) 43. at least one carbohydrate, at least one amino additive; acid, and at least one organic acid; US 2007/01 16831 A1 May 24, 2007 20

0565. 44. at least one carbohydrate, at least one amino 0590 69. at least one carbohydrate, at least one sugar acid, and at least one inorganic acid; acid, and at least one alcohol; 0566 45. at least one carbohydrate, at least one amino 0591 70. at least one carbohydrate, at least one nucle acid, and at least one bitter compound; otide, and at least one organic acid; 0567 46. at least one carbohydrate, at least one amino 0592 71. at least one carbohydrate, at least one nucle acid, and at least one polymer; otide, and at least one inorganic acid; 0568 47. at least one carbohydrate, at least one amino 0593 72. at least one carbohydrate, at least one nucle acid, and at least one protein or protein hydrolysate; otide, and at least one bitter compound; 0569 48. at least one carbohydrate, at least one amino 0594) 73. at least one carbohydrate, at least one nucle acid, and at least one surfactant; otide, and at least one polymer, 0570 49. at least one carbohydrate, at least one amino 0595 74. at least one carbohydrate, at least one nucle acid, and at least one flavonoid; otide, and at least one protein or protein hydrolysate; 0571 50. at least one carbohydrate, at least one amino 0596) 75. at least one carbohydrate, at least one nucle acid, and at least one alcohol; otide, and at least one surfactant; 0572 51. at least one carbohydrate, at least one 0597 76. at least one carbohydrate, at least one nucle polyamino acid, and at least one Sugar acid; otide, and at least one flavonoid; 0573 52. at least one carbohydrate, at least one 0598) 77. at least one carbohydrate, at least one nucle polyamino acid, and at least one nucleotide; otide, and at least one alcohol; 0574 53. at least one carbohydrate, at least one 0599 78. at least one carbohydrate, at least one organic polyamino acid, and at least one organic acid; acid, and at least one inorganic acid; 0575 54. at least one carbohydrate, at least one 0600 79. at least one carbohydrate, at least one organic polyamino acid, and at least one inorganic acid; acid, and at least one bitter compound; 0576 55. at least one carbohydrate, at least one 0601 80. at least one carbohydrate, at least one organic polyamino acid, and at least one bitter compound; acid, and at least one polymer; 0577 56. at least one carbohydrate, at least one 0602) 81. at least one carbohydrate, at least one organic polyamino acid, and at least one polymer; acid, and at least one protein or protein hydrolysate; 0603 82. at least one carbohydrate, at least one organic 0578 57. at least one carbohydrate, at least one polyamino acid, and at least one protein or protein acid, and at least one surfactant; hydrolysate; 0604 83. at least one carbohydrate, at least one organic acid, and at least one flavonoid; 0579) 58. at least one carbohydrate, at least one polyamino acid, and at least one Surfactant; 0605 84. at least one carbohydrate, at least one organic acid, and at least one alcohol; 0580 59. at least one carbohydrate, at least one polyamino acid, and at least one flavonoid; 0606 85. at least one carbohydrate, at least one inorganic acid, and at least one bitter compound; 0581 60. at least one carbohydrate, at least one polyamino acid, and at least one alcohol; 0607 86. at least one carbohydrate, at least one inorganic acid, and at least one polymer; 0582 61. at least one carbohydrate, at least one sugar 0608) 87. at least one carbohydrate, at least one inorganic acid, and at least one nucleotide; acid, and at least one protein or protein hydrolysate; 0583 62. at least one carbohydrate, at least one sugar 0609) 88. at least one carbohydrate, at least one inorganic acid, and at least one organic acid; acid, and at least one surfactant; 0584) 63. at least one carbohydrate, at least one sugar 0610 89. at least one carbohydrate, at least one inorganic acid, and at least one inorganic acid; acid, and at least one flavonoid; 0585 64. at least one carbohydrate, at least one sugar 0611 90. at least one carbohydrate, at least one inorganic acid, and at least one bitter compound; acid, and at least one alcohol; 0586 65. at least one carbohydrate, at least one sugar 0612 91. at least one carbohydrate, at least one bitter acid, and at least one polymer; compound, and at least one polymer, 0587 66. at least one carbohydrate, at least one sugar 0613 92. at least one carbohydrate, at least one bitter acid, and at least one protein or protein hydrolysate; compound, and at least one protein or protein hydrolysate; 0588 67. at least one carbohydrate, at least one sugar 0.614 93. at least one carbohydrate, at least one bitter acid, and at least one surfactant; compound, and at least one Surfactant; 0589 68. at least one carbohydrate, at least one sugar 0615) 94. at least one carbohydrate, at least one bitter acid, and at least one flavonoid; compound, and at least one flavonoid; US 2007/01 16831 A1 May 24, 2007

0616) 95. at least one carbohydrate, at least one bitter 0642) 121. at least one Sweet taste improving additive and compound, and at least one alcohol; allose; 0617. 96. at least one carbohydrate, at least one polymer, 0643) 122. at least one sweet taste improving additive and and at least one protein or protein hydrolysate; altrose; 0618 97. at least one carbohydrate, at least one polymer, 0644 123. at least one sweet taste improving additive and and at least one surfactant; mannoSe; 0619 98. at least one carbohydrate, at least one polymer, 0.645 124. at least one sweet taste improving additive and and at least one flavonoid; idose; 0620 99. at least one carbohydrate, at least one polymer, 0646 125. at least one sweet taste improving additive and and at least one alcohol; talose; 0621 100. at least one carbohydrate, at least one protein 0647. 126. at least one sweet taste improving additive and or protein hydrolysate, and at least one surfactant; lactose; 0622 101. at least one carbohydrate, at least one protein 0648. 127. at least one sweet taste improving additive and or protein hydrolysate, and at least one flavonoid; maltose; 0623 102. at least one carbohydrate, at least one surfac 0649) 128. at least one sweet taste improving additive and tant, and at least one flavonoid; invert Sugar, 0624 103. at least one carbohydrate, at least one surfac 0650 129. at least one sweet taste improving additive and tant, and at least one alcohol; trehalose; 0625 104. at least one carbohydrate, at least one fla 0651) 130. at least one sweet taste improving additive and vonoid, and at least one alcohol; isotrehalose; 0626 105. at least one sweet taste improving additive and 0652) 131. at least one sweet taste improving additive and D-tagatose; neotrehalose; 0627 106. at least one sweet taste improving additive and 0653) 132. at least one sweet taste improving additive and trehalose; palatinose; 0628 107. at least one sweet taste improving additive and 0654) 133. at least one sweet taste improving additive and D-galactose; galactose; 0629) 108. at least one sweet taste improving additive and 0655 134. at least one sweet taste improving additive and rhamnose; beet oligosaccharides; 0630. 109. at least one sweet taste improving additive and 0656) 135. at least one sweet taste improving additive and dextrin; isomalto-oligosaccharides; 0631 110. at least one sweet taste improving additive and 0657 136. at least one sweet taste improving additive and cyclodextrin; isomaltose; 0632 111. at least one sweet taste improving additive and 0658) 137. at least one sweet taste improving additive and B-cyclodextrin; isomaltotriose; 0633 112. at least one sweet taste improving additive and 0659 138. at least one sweet taste improving additive and maltodextrin; panose; 0634 113. at least one sweet taste improving additive and 0660 139. at least one sweet taste improving additive and dextran; Xylo-oligosaccharides; 0635) 114. at least one sweet taste improving additive and 0661 140. at least one sweet taste improving additive and Sucrose; Xylotriose; 0636) 115. at least one sweet taste improving additive and 0662) 141. at least one sweet taste improving additive and glucose: xylobiose; 0637 116. at least one sweet taste improving additive and 0663. 142. at least one sweet taste improving additive and fructose; gentio-oligoscaccharides; 0638) 117. at least one sweet taste improving additive and 0664) 143. at least one sweet taste improving additive and threose; gentiobiose; 0639) 118. at least one sweet taste improving additive and 0.665. 144. at least one sweet taste improving additive and arabinose; gentiotriose; 0640 119. at least one sweet taste improving additive and 0.666 145. at least one sweet taste improving additive and Xylose; gentiotetraose; 0641 120. at least one sweet taste improving additive and 0667 146. at least one sweet taste improving additive and lyxose; Sorbose; US 2007/01 16831 A1 May 24, 2007 22

0668. 147. at least one sweet taste improving additive and 0693) 172. at least one sweet taste improving additive, nigero-oligosaccharides; trehalose, and at least one other carbohydrate; 0669 148. at least one sweet taste improving additive and 0694) 173. at least one sweet taste improving additive, palatinose oligosaccharides; D-galactose, and at least one other carbohydrate; 0670) 149. at least one sweet taste improving additive and 0695) 174. at least one sweet taste improving additive, fucose; rhamnose, and at least one other carbohydrate; 0671 150. at least one sweet taste improving additive and 0696) 175. at least one sweet taste improving additive, fructooligosaccharides; dextrin, and at least one other carbohydrate; 0672) 151. at least one sweet taste improving additive and 0697) 176. at least one sweet taste improving additive, kestose; cyclodextrin, and at least one other carbohydrate; 0673 152. at least one sweet taste improving additive and 0.698) 177. at least one sweet taste improving additive, nystose; B-cyclodextrin, and at least one other carbohydrate; 0674) 153. at least one sweet taste improving additive and 0.699) 178. at least one sweet taste improving additive, maltotetraol; maltodextrin, and at least one other carbohydrate; 0675) 154. at least one sweet taste improving additive and 0700 179. at least one sweet taste improving additive, maltotriol: dextran, and at least one other carbohydrate; 0676 155. at least one sweet taste improving additive and 0701 180. at least one sweet taste improving additive, malto-oligosaccharides; Sucrose, and at least one other carbohydrate; 0677 156. at least one sweet taste improving additive and 0702 181. at least one sweet taste improving additive, maltotriose; glucose, and at least one other carbohydrate; 0678 157. at least one sweet taste improving additive and 0703) 182. at least one sweet taste improving additive, maltotetraose; fructose, and at least one other carbohydrate; 0679) 158. at least one sweet taste improving additive and 0704. 183. at least one sweet taste improving additive, maltopentaose; threose, and at least one other carbohydrate; 0705 184. at least one sweet taste improving additive, 0680 159. at least one sweet taste improving additive and arabinose, and at least one other carbohydrate; maltohexaose; 0706 185. at least one sweet taste improving additive, 0681 160, at least one sweet taste improving additive and maltoheptaose; Xylose, and at least one other carbohydrate; 0707 186. at least one sweet taste improving additive, 0682) 161. at least one sweet taste improving additive and lyxose, and at least one other carbohydrate; lactulose; 0708 187. at least one sweet taste improving additive, 0683) 162. at least one sweet taste improving additive and allose, and at least one other carbohydrate; melibiose; 0709 188. at least one sweet taste improving additive, 0684) 163. at least one sweet taste improving additive and altrose, and at least one other carbohydrate; raffinose; 0710 189. at least one sweet taste improving additive, 0685 164. at least one sweet taste improving additive and mannose, and at least one other carbohydrate; rhamnose; 0711) 190. at least one sweet taste improving additive, 0686) 165. at least one sweet taste improving additive and idose, and at least one other carbohydrate; ribose; 0712 191. at least one sweet taste improving additive, 0687] 166. at least one sweet taste improving additive and talose, and at least one other carbohydrate; isomerized liquid Sugars; 0713 192. at least one sweet taste improving additive, 0688 167. at least one sweet taste improving additive and lactose, and at least one other carbohydrate; high fructose corn syrup (e.g., HFCS55 and HFCS42) or 0714 193. at least one sweet taste improving additive, starch syrup; maltose, and at least one other carbohydrate; 0689) 168. at least one sweet taste improving additive and 0715 194. at least one sweet taste improving additive, coupling Sugars; invert Sugar, and at least one other carbohydrate; 0690) 169. at least one sweet taste improving additive and 0716) 195. at least one sweet taste improving additive, Soybean oligosaccharides; trehalose, and at least one other carbohydrate; 0691 170. at least one sweet taste improving additive and 07.17 196. at least one sweet taste improving additive, glucose syrup; isotrehalose, and at least one other carbohydrate; 0692) 171. at least one sweet taste improving additive, 0718) 197. at least one sweet taste improving additive, D-tagatose, and at least one other carbohydrate; neotrehalose, and at least one other carbohydrate; US 2007/01 16831 A1 May 24, 2007

0719 198. at least one sweet taste improving additive, 0742 221. at least one sweet taste improving additive, palatinose, and at least one other carbohydrate; malto-oligosaccharides, and at least one other carbohy 0720 199. at least one sweet taste improving additive, drate; galaetose, and at least one other carbohydrate; 0743. 222. at least one sweet taste improving additive, 0721 200. at least one sweet taste improving additive, maltotriose, and at least one other carbohydrate; beet oligosaccharides, and at least one other carbohydrate; 0744 223. at least one sweet taste improving additive, maltotetraose, and at least one other carbohydrate; 0722 201. at least one sweet taste improving additive, isomalto-oligosaccharides, and at least one other carbo 0745) 224. at least one sweet taste improving additive, hydrate; maltopentaose, and at least one other carbohydrate; 0723 202. at least one sweet taste improving additive, 07:46 225. at least one sweet taste improving additive, isomaltose, and at least one other carbohydrate; maltohexaose, and at least one other carbohydrate; 0724 203. at least one sweet taste improving additive, 0747. 226. at least one sweet taste improving additive, isomaltotriose, and at least one other carbohydrate; maltoheptaose, and at least one other carbohydrate; 0725 204. at least one sweet taste improving additive, 0748) 227. at least one sweet taste improving additive, panose, and at least one other carbohydrate; lactulose, and at least one other carbohydrate; 0726. 205. at least one sweet taste improving additive, 0749 228. at least one sweet taste improving additive, Xylo-oligosaccharides, and at least one other carbohy melibiose, and at least one other carbohydrate; drate; 0750 229. at least one sweet taste improving additive, 0727 206. at least one sweet taste improving additive, raffinose, and at least one other carbohydrate; XVlotriose, and at least one other carbohydrate; 0751] 230. at least one sweet taste improving additive, 0728, 207. at least one sweet taste improving additive, rhamnose, and at least one other carbohydrate; Xylobiose, and at least one other carbohydrate; 0752 231. at least one sweet taste improving additive, 0729) 208. at least one sweet taste improving additive, ribose, and at least one other carbohydrate; gentio-oligoscaccharides, and at least one other carbohy 0753 232. at least one sweet taste improving additive, drate; isomerized liquid Sugars, and at least one other carbohy 0730, 209. at least one sweet taste improving additive, drate; gentiobiose, and at least one other carbohydrate; 0754) 233. at least one sweet taste improving additive, 0731) 210. at least one sweet taste improving additive, high fructose corn syrup (e.g. HFCS55 and HFCS42) or gentiotriose, and at least one other carbohydrate; starch syrup, and at least one other carbohydrate; 0755 234. at least one sweet taste improving additive, 0732 211 ... at least one Sweetit tastetaSt improvingp g additive,addit coupling Sugars, and at least one other carbohydrate; gentiotetraose, and at least one other carbohydrate; 0756. 235. at least one sweet taste improving additive, 0733 212. at least one sweet taste improving additive, Soybean oligosaccharides, and at least one other carbo Sorbose, and at least one other carbohydrate; hydrate; and 0734) 213. at least one sweet taste improving additive, 0757 236. at least one sweet taste improving additive, nigero-oligosaccharides, and at least one other carbohy glucose syrup, and at least one other carbohydrate. drate; 0758. In another embodiment, the dental composition 0735 214. at least one sweet taste improving additive, comprises at least one natural and/or synthetic high-potency palatinose oligosaccharides, and at least one other carbo Sweetener and an active dental Substance in combination hydrate; with a plurality of sweet taste improving additives, desirably 3 or more Sweet taste improving additives, and even more 0736. 215. at least one sweet taste improving additive, desirably 4 or more Sweet taste improving additives, fucose, and at least one other carbohydrate; wherein each Sweet taste improving additive is present in an 0737 216. at least one sweet taste improving additive, amount Such that no one Sweet taste improving additive fructooligosaccharides, and at least one other carbohy imparts a Substantial off taste to the Sweetener composition. drate; In other words, the amounts of the Sweet taste improving additives in the Sweetener composition are balanced so that 0738 217. at least one sweet taste improving additive, no one Sweet taste improving additive imparts a Substantial kestose, and at least one other carbohydrate; off taste to the Sweetener composition. 0739. 218. at least one sweet taste improving additive, 0759. According to a particular embodiment of this nystose, and at least one other carbohydrate; invention, the Sweetener composition provided herein com prises at least one Sweet taste improving composition in the 07:40 219. at least one sweet taste improving additive, Sweetener composition in an amount effective for the Sweet maltotetraol, and at least one other carbohydrate; ener composition to impart an osmolarity of at least 10 0741. 220. at least one sweet taste improving additive, mOSmoles/L to an aqueous Solution of the Sweetener com maltotriol, and at least one other carbohydrate; position, wherein the at least one natural and/or synthetic US 2007/01 16831 A1 May 24, 2007 24 high-potency Sweetener is present in the aqueous Solution in positions in an amount from about 100 ppm to about 80,000 an amount Sufficient to impart a maximum Sweetness inten ppm. In accordance with other desirable embodiments of sity equivalent to that of a 10% aqueous solution of Sucrose this invention, a Sweet taste improving polyol additive is by weight. As used herein, “mCSmoles/L refers to millios present in Sweetened compositions in an amount from about moles per liter. According to another embodiment, the 400 to about 80,000 ppm. In a sub-embodiment, suitable Sweetener composition comprises at least one Sweet taste Sweet taste improving polyol additives for imparting osmo improving composition in an amount effective for the Sweet larities ranging from about 10 mCSmoles/L to about 500 ener composition to impart an osmolarity of 10 to 500 mOSmoles/L to a Sweetenable composition include, but are mOsmoles/L, preferably 25 to 500 mOsmoles/L preferably, not limited to, Sweet taste improving polyol additives with more preferably 100 to 500 mOsmoles/L, more preferably a molecular weight ranging from about 76 to about 500. 200 to 500 mOsmoles/L, and still more preferably 300 to 0763. In accordance with still other desirable embodi 500 mOsmoles/L to an aqueous solution of the Sweetener ments of this invention, a Sweet taste improving polyol composition wherein the at least one natural and/or synthetic additive is present in Sweetener compositions in an amount hioh-potency Sweetener is present in the aqueous Solution in from about 400 to about 80.000 ppm of the total sweetener an amount Sufficient to impart a maximum Sweetness inten composition, more particularly from about about 5,000 to sity equivalent to that of a 10% aqueous solution of Sucrose about 40,000 ppm, and still more particularly from about by weight. Wherein a plurality of sweet taste improving 10,000 to about 35,000 ppm. Desirably, the at least one compositions are combined with at least one natural and/or natural and/or synthetic high-potency Sweetener and at least synthetic high-potency Sweetener, the osmolarity imparted one Sweet taste improving polyol additive are present in the is that of the total combination of the plurality of Sweet taste Sweetener composition in a ratio from about 1:4 to about improving compositions. 1:800, respectively; more particularly from about 1:20 to 0760 Osmolarity refers to the measure of osmoles of about 1:600; even more particularly from about 1:50 to Solute per liter of Solution, wherein osmole is equal to the about 1:300; and still more particularly from about 1:75 to number of moles of osmotically active particles in an ideal about 1:150. Solution (e.g., a mole of glucose is one oSmole), whereas a mole of sodium chloride is two osmoles (one mole of 0764 Generally, in accordance with another embodiment sodium and one mole of chloride). Thus, in order to improve of this invention, a suitable Sweet taste improving alcohol in the quality of taste of the Sweetener composition, the additive is present in the Sweetener compositions in an osmotically active compounds or the compounds which amount from about 625 to about 10,000 ppm. In another impart osmolarity must not introduce significant off taste to embodiment, Suitable Sweet taste improving alcohol addi the formulation. tives for imparting osmolarities ranging from about 10 mOSmoles/L to about 500 mOsmoles/L to a sweetenable 0761. In one embodiment, suitable sweet taste improving composition include, but are not limited to, Sweet taste carbohydrate additives for the present invention have a improving alcohol additives with a molecular weight rang molecular weight less than or equal to 500 and desirably ing from about 46 to about 500. A non-limiting example of have a molecular weight from 50 to 500. In particular Sweet taste improving alcohol additive with a molecular embodiments, suitable carbohydrates with a molecular weight ranging from about 46 to about 500 includes ethanol. weight less than or equal to 500 include, but are not limited to. Sucrose, fructose, glucose, maltose, lactose, mannose, 0765. In one embodiment, suitable sweet taste improving galactose, and tagatose. Generally, in accordance with desir amino acid additives have a molecular weight of less than or able embodiments of this invention, a Sweet taste improving equal to 250 and desirably have a molecular weight from 75 carbohydrate additive is present in the Sweetener composi to 250. In particular embodiments, suitable sweet taste tions in an amount from about 1,000 to about 100,000 ppm. improving amino acid additives with a molecular weight less (Throughout this specification, the term ppm means parts than or equal to 250 include, but are not limited to, glycine, alanine, serine, Valine, leucine, isoleucine, proline, theanine, per million by weight or volume. For example, 500 ppm and threonine. Preferred Sweet taste improving amino acid means 500 mg in a liter.) In accordance with other desirable additives include those which are Sweet tasting at high embodiments of this invention, a Sweet taste improving concentrations, but desirably are present in embodiments of carbohydrate additive is present in the Sweetened composi this invention at amounts below or above their sweetness tions in an amotnt from about 2,500 to about 10,000 ppm. In taste detection threshold. Even more preferred are mixtures another embodiment, Suitable Sweet taste improving carbo of Sweet taste improving amino acid additives at amounts hydrate additives for imparting osmolarities ranging from below or above their sweetness taste detection threshold. about 10 mCSmoles/L to about 500 mOsmoles/L to a Sweet Generally, in accordance with desirable embodiments of this enable composition include, but are not limited to, Sweet invention, a Sweet taste improving amino acid additive is taste improving carbohydrate additives with a molecular present in the Sweetener compositions in an amount from weight ranging from about 50 to about 500. about 100 ppm to about 25,000 ppm, more particularly from 0762. In one embodiment, suitable sweet taste improving about 1,000 to about 10,000 ppm, and still more particularly polyol additives have a molecular weight less than or equal from about 2,500 to about 5,000 ppm. In accordance with to 500 and desirably have a molecular weight from 76 to other desirable embodiments of this invention, a Sweet taste 500. In particular embodiments, suitable sweet taste improv improving amino acid additive is present in the Sweetened ing polyol additives with a molecular weight less than or compositions in an amount from about 250 ppm to about equal to 500 include, but are not limited to, erythritol, 7,500 ppm. In a sub-embodiment, suitable sweet taste glycerol, and propylene glycol. Generally, in accordance improving amino acid additives for imparting osmolarities with desirable embodiments of this invention, a sweet taste ranging from about 10 mOsmoles/L to about 500 mOs improving polyol additive is present in the Sweetener com moles/L to a Sweetenable composition include, but are not US 2007/01 16831 A1 May 24, 2007

limited to, Sweet taste improving amino acid additives with animal consumption when used in a generally acceptable a molecular weight ranging from about 75 to about 250. range. In a Sub-embodiment, Suitable Suitable Sweet taste improving inorganic acid salt additives for imparting osmo 0766 Generally, in accordance with yet another embodi larities ranging from about 10 mCSmoles/L to about 500 ment of this invention, a Suitable Sweet taste improving mOSmoles/L to a Sweetenable composition include, but are amino acid salt additive is present in the Sweetener compo not limited to, Sweet taste improving inorganic acid salt sitions in an amount from about 25 to about 10,000 ppm, additives with a molecular weight range from about 58 to more particularly from about 1,000 to about 7,500 ppm, and about 120. still more particularly from about 2,500 to about 5,000 ppm. In another embodiment, Suitable Sweet taste improving 0770 Generally, in accordance with still another embodi amino acid salt additives for imparting osmolarities ranging ment of this invention, a Suitable Sweet taste improving from about 10 mCSmoles/L to about 500 mOsmoles/L to a organic acid additive is present in the Sweetener composi Sweetenable composition include, but are not limited to, tions in an amount from about 10 to about 5,000 ppm. In Sweet taste improving amino acid salt additives with a another embodiment, Suitable Sweet taste improving organic molecular weight ranging from about 75 to about 300. acid additives for imparting osmolarities ranging from about Non-limiting examples of Sweet taste improving amino acid 10 mCSmoles/L to about 500 mOsmoles/L to a sweetenable salt additives with a molecular weight ranging from about 75 composition include, but are not limited to, creatin, citric to about 300 include salts of glycine, alanine, serine, thea acid, malic acid. Succinic acid, hydroxycitric acid, tartaric nine, and threonine. acid, fumaric acid, gluconic acid, glutaric acid, adipic acid, and any other Sweet taste improving organic acid additives 0767 Generally, in accordance with still another embodi which are safe for human or animal consumption when used ment of this invention, a Suitable Sweet taste improving in a generally acceptable range. In one embodiment, the protein or protein hydroyslate additive is present in the Sweet taste improving organic acid additive comprises a Sweetener compositions in an amount from about 200 to molecular weight range from about 60 to about 208. about 50,000 ppm. In another embodiment, suitable sweet 0771 Generally, in accordance with still another embodi taste improving protein or protein hydrolysate additives for ment of this invention, a Suitable Sweet taste improving imparting osmolarities ranging from about 10 mOSmoles/L organic acid salt additive is present in the Sweetener com to about 500 mOsmoles/L to a sweetenable composition positions in an amoutin from about 20 to about 10,000 ppm. include, but are not limited to, Sweet taste improving protein In another embodiment, Suitable Sweet taste improving or protein hydrolysate additives with a molecular weight organic acid salt additives for imparting osmolarities rang ranging from about 75 to about 300. Non-limiting examples ing from about 10 mCSmoles/L to about 500 mOsmoles/L to of Sweet taste improving protein or protein hydrolysate a Sweetenable composition include, but are not limited to, additives with a molecular weight ranging from about 75 to salts of Sweet taste improving organic acid additives, such as about 300 include proteins or protein hydrolysates contain Sodium, potassium, calcium, magnesium, and other alkali or ing glycine, alanine, serine, and threonine. alkaline metal salts of citric acid, malic acid, tartaric acid, 0768 Generally, in accordance with another embodiment fumaric acid, gluconic acid, glutaric acid, adipic acid, of this invention, a suitable Sweet taste improving inorganic hydroxycitric acid, Succinic acid, and salts of any other acid additive is present in the Sweetener compositions in an Sweet taste improving organic acid additives which are safe amount from about 25 to about 5,000 ppm. In another for human or animal consumption when used in a generally embodiment, Suitable Sweet taste improving inorganic acid acceptable range. In one embodiment, the Sweet taste additives for imparting osmolarities ranging from about 10 improving organic acid salt additive comprises a molecular mOSmoles/L to about 500 mOsmoles/L to a sweetenable weight range from about 140 to about 208. composition include, but are not limited to, phosphoric acid, 0772 Generally, in accordance with yet another embodi HCl, and HSO and any other inorganic acid additives ment of this invention, a Suitable Sweet taste improving which are safe for human or animal consumption when used organic base salt additive is present in the Sweetener com in a generally acceptable range. In a Sub-embodiment, positions in an amount from about 10 to about 5,000 ppm. Suitable Sweet taste improving inorganic acid additives for In another embodiment, Suitable Sweet taste improving imparting osmolarities ranging from about 10 mOSmoles/L organic base salt additives for imparting osmolarities rang to about 500 mOsmoles/L to a sweetenable composition ing from about 10 mCSmoles/L to about 500 mOsmoles/L to include, but are not limited to, Sweet taste improving inor a Sweetenable composition include, but are not limited to, ganic acid additives with a molecular weight range from inorganic and organic acid salts of organic bases such as about 36 to about 98. glucosarine salts, choline salts, and guanidine salts. 0769 Generally, in accordance with still another embodi 0773 Generally, in accordance with yet another embodi ment of this invention, a Suitable Sweet taste improving ment of this invention, a Suitable Sweet taste improving inorganic acid salt additive is present in the Sweetener astringent additive is present in the Sweetener compositions compositions in an amount from about 25 to about 5,000 in an amount from about 25 to about 1,000 ppm. In another ppm. In another embodiment, Suitable Sweet taste improving embodiment, Suitable Sweet taste improving astringent addi inorganic acid salt additives for imparting osmolarities rang tives for impanting osmolarities ranging from about 10 ing from about 10 mCSmoles/L to about 500 mOsmoles/L to mOSmoles/L to about 500 mOsmoles/L to a sweetenable a Sweetenable composition include, but are not limited to, composition include, but are not limited to, tannic acid, tea salts of inorganic acids, for example sodium, potassium, polyphenols, catechins, aluminum sulfate, AlNaCSO), calcium, and magnesium salts of phosphoric acid, and any AlK(SO), and other forms of alum. other alkali or alkaline earth metal salts of other inorganic 0774 Generally, in accordance with yet another embodi acids (e.g., sodium bisulfate) which are safe for human or ment of this invention, a Suitable Sweet taste improving US 2007/01 16831 A1 May 24, 2007 26 nucleotide additive is present in the Sweetener compositions taste of the natural and/or synthetic high-potency Sweetener in an amount from about 5 to about 1,000 ppm. In another to be more Sugar-like include, but are not limited to, Sweet embodiment, Suitable Sweet taste improving nucleotide taste improving carbohydrate additives with a molecular additives for imparting osmolarities ranging from about 10 weight ranging from about 50 to about 500. Non-limiting mOSmoles/L to about 500 mOsmoles/L to a sweetenable examples of Sweet taste improving carbohydrate additives composition include, but are not limited to, adenosine mono with a molecular weight ranging from about 50 to about 500 phosphate. include Sucrose, fructose, glucose, maltose, lactose, man 0775 Generally, in accordance with yet another embodi nose, galactose, ribose, rhamnose, trehalose, HFCS, and ment of this invention, a Suitable Sweet taste improving tagatose. polyamino acid additive is present in the Sweetener compo 0781. In another embodiment, suitable sweet taste sitions in an amount from about 30 to about 2,000 ppm. In improving polyol additives for improving the osmotic taste another embodiment, Suitable Sweet taste improving of natural and/or synthetic high-potency Sweetener to be polyamino acid additives for imparting osmolarities ranging more Sugar-like include, but are not limited to, Sweet taste from about 10 mCSmoles/L to about 500 mOsmoles/L to a improving polyol additives with a molecular weight ranging Sweetenable composition include, but are not limited to, from about 76 to about 500. Non-limiting examples of Sweet poly-L-lysine (e.g., poly-L-C-lysine or poly-L-e-lysine), taste improving polyol additives with a molecular weight poly-L-Omithine (e.g., poly-L-C-ornithine or poly-L-e-orni ranging from about 76 to about 500 include erythritol, thine), and poly-L-arginine. glycerol, and propylene glycol. In a Sub-embodiment, other 0776 Generally, in accordance with yet another embodi Suitable Sweet taste improving polyol additives include ment of this invention, a Suitable Sweet taste improving Sugar alcohols. polymer additive is present in the Sweetener compositions in 0782. In another embodiment, suitable sweet taste an amount from about 30 to about 2,000 ppm. In another improving alcohol additives for improving the osmotic taste embodiment, Suitable Sweet taste improving polymer addi of natural and/or synthetic high-potency Sweetener to be tives for imparting osmolarities ranging from about 10 more Sugar-like include, but are not limited to, Sweet taste mOSmoles/L to about 500 mOsmoles/L to a sweetenable improving alcohol additives with a molecular weight rang composition include, but are not limited to, chitosan, Sodium ing from about 46 to about 500. A non-limiting example of hexametaphosphate and its salts, pectin, hydrocolloids Such Sweet taste improving alcohol additive with a molecular as gum acacia Senegal, propylene glycol, polyethylene gly weight ranging from about 46 to about 500 includes ethanol. col, and poly(ethylene glycol methyl ether). 0783. In another embodiment, suitable sweet taste 0777 Generally, in accordance with yet another embodi improving amino acid additives for improving the osmotic ment of this invention, a Suitable Sweet taste improving taste of natural and/or synthetic high-potency Sweetener to Surfactant additive is present in the Sweetener compositions be more Sugar-like include, but are not limited to, Sweet taste in an amount from about 1 to about 5,000 ppm. In another improving amino acid additives with a molecular weight embodiment, Suitable Sweet taste improving Surfactant addi ranging from about 75 to about 250. Non-limiting examples tives for imparting osmolarities ranging from about 10 of Sweet taste improving amino acid additives with a mOSmoles/L to about 500 mOsmoles/L to a sweetenable molecular weight ranging from about 75 to about 250 composition include, but are not limited to, polysorbates, include glycine, alanine, serine, leucine, Valine, isoleucine, choline chloride, Sodium taurocholate, lecithins, Sucrose proline, hydroxyproline, glutamine, theanine, and threonine. oleate esters, Sucrose Stearate esters, Sucrose palmitate 0784. In another embodiment, suitable sweet taste esters, and Sucrlose laurate esters. improving amino acid salt additives for improving the 0778 Generally, in accordance with yet another embodi osmotic taste of natural and/or synthetic high-potency ment of this invention, a Suitable Sweet taste improving Sweetener to be more Sugar-like include, but are not limited flavonoid additive is present in the Sweetener compositions to, Sweet taste improving amino acid salt additives with a in an amount from about 0.1 to about 1,000 ppm. In another molecular weight ranging from about 75 to about 300. embodiment, Suitable Sweet taste improving flavonoid addi Non-limiting examples of Sweet taste improving amino acid tives for imparting osmolarities ranging from about 10 salt additives with a molecular weight ranging from about 75 mOSmoles/L to about 500 mOsmoles/L to a sweetenable to about 300 include salts of glycine, alanine, serine, leucine, composition include, but are not limited to, naringin, cat valine, isoleucine, proline, hydroxyproline, glutamine, thea echins, rutins, neohesperidin, and neohesperidin dihydroch nine, and threonine. alcone. 0785. In another embodiment, suitable sweet taste 0779. In a preferred embodiment, non-limiting examples improving protein or protein hydrolysate additives for of Sweet taste improving compositions enhancing the natural improving the osmotic taste of natural and/or synthetic and/or synthetic high-potency Sweetener's osmotic taste to high-potency Sweetener to be more Sugar-like include, but be more Sugar-like include Sweet taste improving carbohy are not limited to, Sweet taste improving protein or protein drate additives, Sweet taste improving alcohol additives, hydrolysate additives with a molecular weight ranging from Sweet taste improving polyol additives, Sweet taste improv about 75 to about 300. Non-limiting examples of Sweet taste ing amino acid additives, Sweet taste improving amino acid improving protein or protein hydrolysate additives with a salt additives, Sweet taste improving inorganic acid salt molecular weight ranging from about 75 to about 300 additives, Sweet taste improving polymer additives, and include protein or protein hydrolysates containing glycine, Sweet taste improving protein or protein hydrolysate addi alanine, serine, leucine, Valine, isoleucine, proline, and tives. threonine. 0780. In another embodiment, suitable sweet taste 0786. In another embodiment, suitable sweet taste improving carbohydrate additives for improving the osmotic improving inorganic acid salt additives for improving the US 2007/01 16831 A1 May 24, 2007 27 osmotic taste of natural and/or synthetic high-potency oligosaccharides, reduced Xylo-oligosaccharides, reduced Sweetener to be more Sugar-like include, but are not limited gentio-oligosaccharides, reduced maltose syrup, or reduced to, Sodium chloride, potassium chloride, magnesium chlo glucose syrup. ride, KHPO and NaH2PO. Suitable sweet taste improving 0791. In another embodiment, a dental composition is inorganic acid salt additives for improving the osmotic taste provided comprising an active dental Substance and at least may comprise a molecular weight from about 58 to about one natural and/or synthetic high-potency Sweetener in 120. combination with at least one Sweet taste improving amino 0787. In another embodiment, suitable sweet taste acid additive chosen from aspartic acid, arginine, glycine, improving bitter additives for improving the osmotic taste of glutamic acid, proline, threonine, theanine, cysteine, cystine, the natural and/or synthetic high-potency Sweetener to be alanine, Valine, tyrosine, leucine, isoleucine, asparagine, serine, lysine, histidine, ornithine, methionine, camitine, more Sugar-like include, but are not limited to, caffeine, aminobutyric acid (alpha-, beta-, and gamma-isomers), quinine, urea, quassia, tannic acid, and naringin. glutamine, hydroxyproline, taurine, norvaline, sarcosine, or IV. Dental Compositions salts thereof, 0788. In one embodiment, a dental composition is pro 0792. In another embodiment, a dental composition is vided comprising an active dental Substance and at least one provided comprising an active dental Substance and at least natural and/or synthetic high-potency Sweetener in combi one natural and/or synthetic high-potency Sweetener in nation with at least one Sweet taste improving nucleotide combination with at least one Sweet taste improving additive chosen from inosine monophosphate (IMP), gua polyamino acid additive chosen from poly-L-aspartic acid, nosine monophosphate (“GMP), adenosine monophos poly-L-lysine (e.g., poly-L-C-lysine or poly-L-e-lysine), phate (AMP), cytosine monophosphate (CMP), uracil poly-L-ornithine (e.g., poly-L-C-ornithine or poly-L-e-orni monophosphate (UMP), inosine diphosphate, guanosine thine), poly-L-arginine, other polymeric forms of amino diphosphate, adenosine diphosphate, cytosine diphosphate, acids, or salts thereof. uracil diphosphate, inosine triphosphate, guanosine triphos 0793. In another embodiment, a dental composition is phate, adenosine triphosphate, cytosine triphosphate, uracil provided comprising an active dental Substance and at least triphosphate, nucleosides thereof nucleic acid bases thereof, one natural and/or synthetic high-potency Sweetener in or salts thereof. combination with at least one Sweet taste improving Sugar acid additive chosen from aldonic, uronic, aldaric, alginic, 0789. In one embodiment, a dental composition is pro gluconic, glucuronic, giucaric, galactaric, galacturonic, or vided comprising an active dental Substance and at least one salts thereof. natural and/or synthetic high-potency Sweetener in combi nation with at least one Sweet taste improving carbohydrate 0794. In another embodiment, a dental composition is additive chosen from tagatose, trehalose, galactose, rham provided comprising an active dental Substance and at least nose, cyclodextrin (e.g., C-cyclodextrin, B-cyclodextrin, and one natural and/or synthetic high-potency Sweetener in 6-cyclodextrin), maltodextrin (including resistant maltodex combination with at least one Sweet taste improving organic trins such as Fibersol-2TM), dextran, sucrose, glucose, ribu acid additive chosen from C2-C30 carboxylic acids, substi lose, fructose, threose, arabinose, Xylose, lyxose, allose, tuted hydroxyl C1-C30 carboxylic acids, benzoic acid, sub altrose, mannose, idose, lactose, maltose, invert Sugar, stituted benzoic acids (e.g., 2,4-dihydroxybenzoic acid), isotrehalose, neotrehalose, palatinose or isomalitulose, eryth Substituted cinnamic acids, hydroxyacids, Substituted rose, deoxyribose, gulose, idose, talose, erythrulose, Xylu hydroxybenzoic acids, substituted cyclohexyl carboxvlic lose, psicose, turanose, cellobiose, amylopectin, glu acids, tannic acid, lactic acid, tartaric acid, citric acid, cosamine, mannosamine, fucose, glucuronic acid, gluconic gluconic acid, glucoheptonic acids, glutaric acid, creatine, acid, glucono-lactone, abequose, galactosamine, beet oli adipic acid, hydroxycitric acid, malic acid, fruitaric acid, gosaccharides, isomalto-oligosaccharides (isomaltose, iso fumaric acid, maleic acid, Succinic acid, chlorogenic acid, maltotriose, panose and the like), Xylo-oligosaccharides salicylic acid, caffeic acid, bile acids, acetic acid, ascorbic (Xylotriose, Xylobiose and the like), gentio-oligoscaccha acid, alginic acid, erythorbic acid, polyglutamic acid, or salts rides (gentiobiose, gentiotriose, geniotetraose and the like), thereof. Sorbose, nigero-oligosaccharides, palatinose oligosaccha 0795. In another embodiment, a dental composition is rides, fucose, fructooligosaccharides (kestose, nystose and provided comprising an active dental Substance and at least the like), maltotetraol, maltotriol, malto-oligosaccharides one natural and/or synthetic high-potency Sweetener in (maltotriose, maltotetraose, maltopentaose, maltohexaose, combination with at least one Sweet taste improving inor maltoheptaose and the like), lactulose, melibiose, raffinose, ganic acid additive chosen from phosphoric acid, phospho rhamnose, ribose, isomerized liquid Sugars such as high rous acid, polyphosphoric acid, hydrochloric acid, Sulfuric fructose corn/starch syrup (e.g., HFCS55, HFCS42, acid, carbonic acid, sodium dihydrogen phosphate, or salts HFCS90), coupling Sugars, soybean oligosaccharides, or thereof. glucose syrup. 0796. In another embodiment, a dental composition is 0790. In another embodiment, a dental composition is provided comprising an active dental Substance and at least provided comprising an active dental Substance and at least one natural and/or synthetic high-potency Sweetener in one natural and/or synthetic high-potency Sweetener in combination with at least one Sweet taste improving bitter combination with at least one Sweet taste improving polyol compound additive chosen from caffeine, quinine, urea, additive chosen from erythritol, maltitol, mannitol, sorbitol, bitter orange oil, naringin, quassia, or salts thereof lactitol. Xylitol, inositol, isomalt, propylene glycol, glycerol 0797. In another embodiment, a dental composition is (glycerine), threitol, galactitol, palatinose, reduced isomalto provided comprising an active dental Substance and at least US 2007/01 16831 A1 May 24, 2007 28 one natural and/or synthetic high-potency Sweetener in one natural and/or synthetic high-potency Sweetener in combination with at least one Sweet taste improving fla combination with at least one Sweet taste improving fla Vorant additive chosen from Vanillin, Vanilla extract, mango vonoid additive chosen from catechins, polyphenols, rutins, extract, cinnamon, citrus, coconut, ginger, viridiflorol, neohesperidin, naringin, neohesperidin dihydrochalcone, or almond, menthol, grape skin extract, or grape seed extract. the like. In another particular embodiment, the at least one Sweet taste improving flavorant additive comprises a proprietary 0802. In another embodiment, a dental composition is sweetener chosen from DöhlerTM Natural Flavoring Sweet provided comprising an active dental Substance and at least ness Enhancer K14323 (Döhler'TM, Darmstadt, Germany), one natural and/or synthetic high-potency Sweetener in SymriseTM Natural Flavor Mask for Sweeteners 161453 or combination with ethanol. 164126 (SymriseTM, Holzminden, Germany), Natural 0803. In another embodiment, a dental composition is AdvantageTM Bitterness Blockers 1, 2, 9 or 10 (Natural provided comprising an active dental Substance and at least AdvantageTM, Freehold, N.J., U.S.A.), or SucramaskTM one natural and/or synthetic high-potency Sweetener in (Creative Research Management, Stockton, Calif., U.S.A.) combination with at least one Sweet taste improving astrin gent compound additive chosen from tannic acid, europium 0798. In another embodiment, a dental composition is chloride (EuCl), gadolinium chloride (GdCl), terbium provided comprising an active dental Substance and at least chloride (TbCls), alum, tannic acid, and polyphenols (e.g., one natural and/or synthetic high-potency Sweetener in tea polyphenol). combination with at least one Sweet taste improving polymer additive chosen from chitosan, pectin, pectic, pectinic, 0804. In another embodiment, a dental composition is polyuronic, polygalacturonic acid, starch, food hydrocolloid provided comprising an active dental Substance and at least or crude extracts thereof (e.g., gum acacia Senegal, gum one natural and/or synthetic high-potency Sweetener in acacia Seyal, carageenan), poly-L-lysine (e.g., poly-L-C- combination with at least one Sweet taste improving inor lysine or poly-L-e-lysine), polyornithine (e.g., poly-L-C- ganic salt additive chosen from Sodium chloride, potassium ornithine or poly-e-ornithine), polypropylene glycol, poly chloride, sodium dihydrogen phosphate, Sodium sulfate, ethylene glycol, poly(ethylene glycol methyl ether), potassium citrate, europium chloride (EuCl), gadolinium polyarginine, polyaspartic acid, polyglutamic acid, polyeth chloride (GdCl), terbium chloride (TbCl), magnesium yleneimine, alginic acid, sodium alginate, propylene glycol Sulfate, magnesium phosphate, alum, magnesium chloride, alginate, sodium polyethyleneglycolalginate, sodium hex mono-, di-, tri-basic sodium or potassium salts of phosphoric ametaphosphate and its salts, or other cationic and anionic acid, salts of hydrochloric acid, sodium carbonate, or polymers. Sodium bicarbonate. 0799. In another embodiment, a dental composition is 0805. In another embodiment, a dental composition is provided comprising an active dental Substance and at least provided comprising an active dental Substance and at least one natural and/or synthetic high-potency Sweetener in one natural and/or synthetic high-potency Sweetener in combination with at least one Sweet taste improving protein combination with at least one Sweet taste improving organic hydrolysate additive chosen from bovine serum albumin salt additive chosen from choline chloride, gluconic acid (BSA), whey protein (including fractions or concentrates Sodium salt, gluconic acid potassium salt, guanidine HCl, thereof such as 90% instant whey protein isolate, 34% whey amiloride HCl, glucosamine HCl, monosodium glutamate protein, 50% hydrolyzed whey protein, and 80% whey (MSG), adenosine monophosphate salt, magnesium glucon protein concentrate), Soluble rice protein, soy protein, pro ate, potassium tartrate, and Sodium tartrate. tein isolates, protein hydrolysates, reaction products of pro 0806. In another embodiment, a dental composition is tein hydrolysates, glycoproteins, and/or proteoglycans con provided comprising an active dental Substance and at least taining amino acids (e.g., glycine, alanine, serine, threonine, one natural and/or synthetic high-potency Sweetener in theanine, asparagine, glutamine, arginine, Valine, isoleucine, combination with at least one Sweet taste improving nucle leucine, norvaline, methionine, proline, tyrosine, hydrox otide additive, at least one Sweet taste improving carbohy yproline, or the like). drate additive, and at least one Sweet taste improving amino 0800 In another embodiment, a dental composition is acid additive; wherein the at least one nucleotide additive is provided comprising an active dental Substance and at least chosen from inosine monophosphate (IMP), guanosine one natural and/or synthetic high-potency Sweetener in monophosphate (“GMP), adenosine monophosphate combination with at least one Sweet taste improving Surfac (“AMP), cytosine monophosphate (CMP), uracil mono tant additive chosen from polysorbates (e.g., polyoxyethyl phosphate (UMP), inosine diphosphaie, guanosine diphos ene sorbitan monooleate (polysorbate 80), polysorbate 20, phate, adenosine diphosphate, cytosine diphosphate, uracil polysorbate 60), sodium dodecylbenzenesulfonate, dioctyl diphosphate, inosine triphosphate, guanosine triphosphate, SulfoSuccinate or dioctyl sulfoSuccinate Sodium, sodium adenosine triphosphate, cytosine triphosphate, uracil triph dodecyl sulfate, cetylpyridinium chloride, hexadecyltrim osphate, nucleosides thereof, nucleic acid bases thereof, or ethylammonium bromide, Sodium cholate, carbamoyl, cho salts thereof; wherein the at least one carbohydrate additive line chloride, Sodium glycocholate, Sodium taurocholate, is chosen from tagatose, trehalose, galactose, rhamnose, Sodium taurodeoxycholate, lauric arginate, Sodium Stearoyl cyclodextrin (e.g., C.-cyclodextrin, B-cyclodextrin, and Y-cy lactylate, lecithins, Sucrose oleate esters, Sucrose Stearate clodextrin), maltodextrin (including resistant maltodextrins esters, sucrose palmitate esters, sucrose laurate esters, and such as Fibersol-2TM), dextran, sucrose, glucose, ribulose, other emulsifiers, or the like. fructose, threose, arabinose, Xylose, lyxose, allose, altrose, mannose, idose, lactose, maltose, invert Sugar, isotrehalose, 0801. In another embodiment, a dental composition is neotrehalose, palatinose or isomalitulose, erythrose, deoxyri provided comprising an active dental Substance and at least bose, gulose, idose, talose, erythrulose, Xylulose, psicose, US 2007/01 16831 A1 May 24, 2007 29 turanose, cellobiose, amylopectin, glucosamine, man one natural and/or synthetic high-potency Sweetener in nosamine, fucose, glucuronic acid, gluconic acid, glucono combination with at least one Sweet taste improving nucle lactone, abequose, galactosamine, beet oligosaccharides, otide additive and at least one Sweet taste improving polyol isomalto-oligosaccharides (isomaltose, isomaltotriose, additive; wherein the at least one nucleotide additive is panose and the like), Xylo-oligosaccharides (Xylotriose, chosen from inosine monophosphate (IMP), guanosine Xylobiose and the like), gentio-oligoscaccharides (gentio monophosphate (“GMP), adenosine monophosphate biose, gentiotriose, gentiotetraose and the like), Sorbose, (“AMP), cytosine monophosphate (CMP), uracil mono nigero-oligosaccharides, palatinose oligosaccharides, phosphate (UMP), inosine diphosphate, guanosine diphos fucose, fructooligosaccharides (kestose, nystose and the phate, adenosine diphosphate, cytosine diphosphate, uracil like), maltotetraol, maltotriol, malto-oligosaccharides (mal diphosphate, inosine triphosphate, guanosine triphosphate, totriose, maltotetraose, maltopentaose, maltohexaose, mal adenosine triphosphate, cytosine triphosphate, uracil triph toheptaose and the like), lactulose, melibiose, raffinose, osphate, nucleosides thereof, nucleic acid bases thereof, or rhamnose, ribose, isomerized liquid Sugars such as high salts thereof; and wherein the at least one polyol additive is fructose corn/starch syrup (e.g., HFCS55, HFCS42, chosen from erythritol, maltitol, mannitol, sorbitol, lactitol, HFCS90), coupling Sugars, soybean oligosaccharides, or Xylitol, inositol, isomalt, propylene glycol, glycerol (glyc glucose syrup; and wherein the at least one amino acid erine), threitol, galactitol, palatinose, reduced isomalto-oli additive is chosen from aspartic acid, arginine, glycine, gosaccharides, reduced Xylo-oligosaccharides, reduced gen glutamic acid, proline, threonine, theanine, cysteine, cystine, tio-oligosaccharides, reduced maltose syrup, or reduced alanine, Valine, tyrosine, leucine, isoleucine, asparagine, glucose syrup. serine, lysine, histidine, ornithine, methionine, carnitine, 0809. In another embodiment, a dental composition is aminobutyric acid (alpha-, beta-, and gamma-isomers), provided comprising an active dental Substance and at least glutamine, hydroxyproline, taurine, norvaline, sarcosine, or one natural and/or synthetic high-potency Sweetener in salts thereof. combination with at least one Sweet taste improving nucle 0807. In another embodiment, a dental composition is otide additive and at least one Sweet taste improving amino provided comprising an active dental Substance and at least acid; wherein the at least one nucleotide additive is chosen one natural and/or synthetic high-potency Sweetener in from inosine monophosphate (IMP), guanosine mono combination with at least one Sweet taste improving nucle phosphate (“GMP), adenosine monophosphate (AMP), otide additive and at least one Sweet taste improving carbo cytosine monophosphate (CMP), uracil monophosphate hydrate additive; wherein the at least one nucleotide additive (UMP), inosine diphosphate, guanosine diphosphate, is chosen from inosine monophosphate (IMP), guanosine adenosine diphosphate, cytosine diphosphate, uracil diphos monophosphate (“GMP), adenosine monophosphate phate, inosine triphosphate, guanosine triphosphate, adenos (AMP), cytosine monophosphate (CMP), uracil mono ine triphosphate, cytosine triphosphate, uracil triphosphate, phosphate (UMP), inosine diphosphate, guanosine diphos nucleosides thereof, nucleic acid bases thereof, or salts phate, adenosine diphosphate, cytosine diphosphate, uracil thereof, and wherein the at least one amino acid additive is diphosphate, inosine triphosphate, guanosine triphosphate, chosen from aspartic acid, arginine, glycine, glutamic acid, adenosine triphosphate, cytosine triphosphate, uracil triph proline, threonine, theanine, cysteine, cystine, alanine, osphate, nucleosides thereof, nucleic acid bases thereof, or valine, tyrosine, leucine, isoleucine, asparagine, serine, salts thereof; and wherein the at least one carbohydrate lysine, histidine, omithine, methionine, carnitine, aminobu additive is chosen from tagatose, trehalose, galactose, rham tyric acid (alpha-, beta-, and gamma-isomers), glutamine, nose, cyclodextrin (e.g., C-cyclodextrin, B-cyclodextrin, and hydroxyproline, taurine, norvaline, sarcosine, or salts Y-cyclodextrin), maltodextrin (including resistant maltodex thereof. trins such as Fibersol-2TM), dextran, sucrose, glucose, ribu 0810. In another embodiment, a dental composition is lose, fructose, threose, arabinose, Xylose lyxose, allose, provided comprising an active dental Substance and at least altrose, mannose, idose, lactose, maltose, invert Sugar, one natural and/or synthetic high-potency Sweetener in isotrehalose, neotrehalose, palatinose or isomalitulose, eryth combination with at least one Sweet taste improving carbo rose, deoxyribose, gulose, idose, talose, erythrulose, Xylu hydrate additive, at least one Sweet taste improving polyol lose, psicose, turanose, cellobiose, amylopectin, glu additive, and at least one Sweet taste improving amino acid cosamine, mannosamine, fucose, glucuronic acid, gluconic additive; wherein the at least one carbohydrate additive is acid, glucono-lactone, abequose, galactosamine, beet oli chosen from tagatose, trehalose, galactose, rhamnose, cyclo gosaccharides, isomalto-oligosaccharides (isomaltose, iso dextrin (e.g., C.-cyclodextrin, B-cyclodextrin, and Y-cyclo maltotriose, panose and the like), Xylo-oligosaccharides dextrin), maltodextrin (including resistant maltodextrins (Xylotriose, Xylobiose and the like), gentio-oligoscaccha such as Fibersol-2TM), dextran, sucrose, glucose, ribulose, rides (gentiobiose, gentiotriose, genetiotetraose and the fructose, threose, arabinose, Xylose, lyxose, allose, altrose, like), Sorbose, nigero-oligosaccharides, palatinose oligosac mannose, idose, lactose, maltose, invert Sugar, isotrehalose, charides, fucose, fructooligosaccharides (kestose, nystose neotrehalose, palatinose or isomalitulose, erythrose, deoxyri and the like), maltotetraol, maltotriol, malto-oligosaccha bose, gulose, idose, talose, crythrulose, Xylulose, psicose, rides (maltotriose, maltotetraose, maltopentaose, malto turanose, cellobiose, amylopectin, glucosamine, man hexaose, maltoheptaose and the like), lactulose, melibiose, nosamine, fucose, glucuronic acid, gluconic acid, glucono raffinose, rhamnose, ribose, isomerized liquid Sugars such as lactone, abequose, galactosamine, beet oligosaccharides, high fructose corn/starch syrup (e.g., HFCS55, HFCS42, isomalto-oligosaccharides (isomaltose, isomaltotriose, HFCS90), coupling Sugars, soybean oligosaccharides, or panose and the like), Xylo-oligosaccharides (Xylotriose, glucose syrup. Xylobiose and the like), gentio-oligoscaccharides (gentio 0808. In another embodiment, a dental composition is biose, gentiotriose, gentiotetraose and the like), Sorbose, provided comprising an active dental Substance and at least nigero-oligosaccharides, palatinose oligosaccharides, US 2007/01 16831 A1 May 24, 2007 30 fucose, fructooligosaccharides (kestose, nystose and the nose, cyclodextrin (e.g., C-cyclodextrin, 3-cyclodextrin, and like), maltotetraol, maltotriol, malto-oligosaccharides (mal Y-cyclodextrin), maltodextrin (including resistant maltodex totriose, maltotetraose, maltopentaose, maltohexaose, mal trins such as Fibersol-2TM), dextran, sucrose, glucose, ribu toheptaose and the like), lactulose, melibiose, raffinose, lose, fructose, threose, arabinose, Xylose, lyxose, allose, rhamnose, ribose, isomerized liquid Sugars such as high altrose, mannose, idose, lactose, maltose, invert Sugar, fructose corn/starch syrup (e.g., HFCS55, HFCS42, isotrehalose, neotrehalose, palatinose or isomalitulose, eryth HFCS90), coupling Sugars, soybean oligosaccharides, or rose, deoxyribose, gulose, idose, talose, erythrulose, Xylu glucose syrup; wherein the at least one polyol additive is lose, psicose, turanose, cellobiose, amylopectin, glu chosen from erythritol, maltitol, mannitol, sorbitol, lactitol, cosamine, mannosamine, fucose, glucuronic acid, gluconic Xylitol, inositol, isomalt, propylene glycol, glycerol (glyc acid, glucono-lactone, abequose, galactosamine, beet oli erine), threitol, galactitol, palatinose, reduced isomalto-oli gosaccharides, isomalto-oligosaccharides (isomaltose, iso gosaccharides, reduced Xylo-oligosaccharides, reduced gen maltotriose, panose and the like), Xylo-oligosaccharides tio-oligosaccharides, reduced maltose syrup, or reduced (Xylotriose, Xylobiose and the like), gentio-oligoscaccha glucose syrup; and wherein the at least one amino acid rides (gentiobiose, gentiotriose, gentiotetraose and the like), additive is chosen from aspartic acid, arginine, glycine, Sorbose, nigero-oligosaccharides, palatinose oligosaccha glutamic acid, proline, threonine, theanine, cysteine, cystine, rides, fucose, fructooligosaccharides (kestose, nystose and alanine, Valine, tyrosine, leucine, isoleucine, asparagine, the like), maltotetraol, maltotriol, malto-oligosaccharides serine, lysine, histidine, ornithine, methionine, carnitine, (maltotriose, maltotetraose, maltopentaose, maltohexaose, aminobutyric acid (alpha-, beta-, and gamma-isomers), maltoheptaose and the like), lactulose, melibiose, raffinose, glutamine, hydroxyproline, taurine, norvaline, sarcosine, or rhamnose, ribose, isomerized liquid Sugars Such as high salts thereof. fructose corn/starch syrup (e.g., HFCS55, HFCS42, 0811. In another embodiment, a dental composition is HFCS90), coupling Sugars, soybean oligosaccharides, or provided comprising an active dental Substance and at least glucose syrup; and wherein the at least one amino acid one natural and/or synthetic high-potency Sweetener in additive is chosen from aspartic acid, arginine, glycine, combination with at least one Sweet taste improving carbo glutamic acid, proline, threonine, theanine, cysteine, cystine, hydrate additive and at least one Sweet taste improving alanine, Valine, tyrosine, leucine, isoleucine, asparagine, polyol additive; wherein the at least one carbohydrate addi serine, lysine, histidine, omithine, methionine, carnitine, tive is chosen from tagatose, trehalose, galactose, rhamnose, aminobutyric acid (alpha-, beta-, and gamma-isomers), cyclodextrin (e.g., C-cyclodextrin, f-cyclodextrin, and Y-cy glutamine, hydroxyproline, taurine, norvaline, sarcosine, or clodextrin), maltodextrin (including resistant maltodextrins salts thereof. such as Fibersol-2TM), dextran, sucrose, glucose, ribulose, 0813. In another embodiment, a dental composition is fructose, threose, arabinose, Xylose, lyxose, allose, altrose, provided comprising an active dental Substance and at least mannose, idose, lactose, maltose, invert Sugar, isotrehalose, one natural and/or synthetic high-potency Sweetener in neotrehalose, palatinose or isomalitulose, erythrose, deoxyri combination with at least one Sweet taste improving polyol bose, gulose, idose, talose, erythrulose, Xylulose, psicose, additive and at least one Sweet taste improving amino acid turanose, cellobiose, amylopectin, glucosamine, man additive; wherein the at least one polyol additive is chosen nosamine, fucose, glucuronic acid, gluconic acid, glucono from erythritol, maltitol, mannitol, sorbitol, lactitol, xylitol, lactone, abequose, galactosamine, beet oligosaccharides, inositol, isomalt, propylene glycol, glycerol (glycerin), isomalto-oligosaccharides (isomaltose, isomaltotriose, threitol, galactitol, palatinose, reduced isomalto-oligosac panose and the like), Xylo-oligosaccharides (Xylotriose, charides, reduced Xylo-oligosaccharides, reduced gentio Xylobiose and the like), gentio-oligoscaccharides (gentio oligosaccharides, reduced maltose syrup, or reduced glucose biose, gentiotriose, gentiotetraose and the like), Sorbose, syrup; and wherein the at least one amino acid additive is nigero-oligosaccharides, palatinose oligosaccharides, chosen from aspartic acid, arginine, glycine, glutamic acid, fucose, fructooligosaccharides (kestose, nystose and the proline, threonine, theanine, cysteine, cystine, alanine, like), maltotetraol, maltotriol, malto-oligosaccharides (mal valine, tyrosine, leucine, isoleucine, asparagine, serine, totriose, maltotetraose, maltopentaose, maltohexaose, mal lysine, histidine, ornithine, methionine, carnitine, aminobu toheptaose and the like), lactulose, melibiose, raffinose, tyric acid (alpha-, beta-, and gamma-isomers), glutamine, rhamnose, ribose, isomerized liquid Sugars such as high hydroxyproline, taurine, norvaline, sarcosine, or salts fructose corn/starch syrup (e.g., HHFCS55, HFCS42, thereof. HFCS90), coupling Sugars, soybean oligosaccharides, or 0814. In another embodiment, a dental composition is glucose syrup; and wherein the at least one polyol additive provided comprising an active dental Substance and at least is chosen from erythritol, maltitol, mannitol, Sorbitol, lacti one natural and/or synthetic high-potency Sweetener in tol. Xylitol, inositol, isomalt, propylene glycol, glycerol combination with at least one Sweet taste improving polyol (glycerine), threitol, galactitol, palatinose, reduced isomalto additive and at least one Sweet taste improving inorganic salt oligosaccharides, reduced Xylo-oligosaccharides, reduced additive; wherein the at least one polyol additive is chosen gentio-oligosaccharides, reduced maltose syrup, or reduced from erythritol, maltitol, mannitol, sorbitol, lactitol, xylitol, glucose syrup. inositol, isomalt, propylene glycol, glycerol (glycerin), 0812. In another embodiment, a dental composition is threitol, galactitol, palatinose, reduced isomalto-oligosac provided comprising an active dental Substance and at least charides, reduced Xylo-oligosaccharides, reduced gentio one natural and/or synthetic high-potency Sweetener in oligosaccharides, reduced maltose syrup, or reduced glucose combination with at least one Sweet taste improving carbo syrup; and wherein the at least one inorganic salt additive is hydrate additive and at least one Sweet taste improving chosen from Sodium chloride, potassium chloride, sodium amino acid additive; wherein the at least one carbohydrate dihydrogen phosphate, Sodium sulfate, potassium citrate, additive is chosen from tagatose, trehalose, galactose, rham europium chloride (EuCl), gadolinium chloride (GdCl3). US 2007/01 16831 A1 May 24, 2007

terbium chloride (TbCls), magnesium Sulfate, alum, mag Sorbose, nigero-oligosaccharides, palatinose oligosaccha nesium chloride, mono-, di-, tri-basic sodium or potassium rides, fucose, fructooligosaccharides (kestose, nystose and salts of phosphoric acid, salts of hydrochloric acid, sodium the like), maltotetraol, maltotriol, malto-oligosaccharides carbonate, sodium bisulfate, or sodium bicarbonate. (maltotriose, maltotetraose, maltopentaose, maltohexaose, 0815. In another embodiment, a dental composition is maltoheptaose and the like), lactulose, melibiose, raffinose, provided comprising an active dental Substance and at least rhamnose, ribose, isomerized liquid Sugars Such as high one natural and/or synthetic high-potency Sweetener in fructose corn/starch syrup (e.g., HFCS55, HFCS42, combination with at least one Sweet taste improving carbo HFCS90), coupling Sugars, soybean oligosaccharides, or hydrate additive and at least one Sweet taste improving glucose syrup; wherein the at least one amino acid additive inorganic salt additive; wherein the at least one carbohydrate is chosen from aspartic acid, arginine, glycine, glutamic additive is chosen from tagatose, trehalose, galactose, rham acid, proline, threonine, theanine, cysteine, cystine, alanine, nose, cyclodextrin (e.g., C-cyclodextrin, B-cyclodextrin, and valine, tyrosine, leucine, isoleucine, asparagine, serine, Y-cyclodextrin), maltodextrin (including resistant maltodex lysine, histidine, ornithine, methionine, carnitine, aminobu trins such as Fibersol-2TM), dextran, sucrose, glucose, ribu tyric acid (alpha-, beta-, and gamma-isomers), glutamine, lose, fructose, threose, arabinose, Xylose, lyxose, allose, hydroxyproline, taurine, norvaline, sarcosine, or salts altrose, mannose, idose, lactose, maltose, invert Sugar, thereof, and wherein the at least one inorganic salt additive isotrehalose, neotrehalose, palatinose or isomalitulose, eryth is chosen from Sodium chloride, potassium chloride, sodium rose, deoxyribose, gulose, idose, talose, erythrulose, Xylu Sulfate, potassium citrate, europium chloride (EuCl), gado lose, psicose, turanose, cellobiose, amylopectin, glu linium chloride (GdCl), terbium chloride (TbCl), magne cosamine, mannosamine, fucose, glucuronic acid, gluconic sium phosphate, magnesium Sulfate, alum, magnesium chlo acid, glucono-lactone, abequose, galactosamine, beet oli ride, mono-, di-, tri-basic sodium or potassium salts of gosaccharides, isomalto-oligosaccharides (isomaltose, iso phosphoric acid, salts of hydrochloric acid, Sodium carbon maltotriose, panose and the like), Xylo-oligosaccharides ate, sodium bisulfate, or sodium bicarbonate. (Xylotriose, Xylobiose and the like), gentio-oligoscaccha 0817. In another embodiment, a dental composition is rides (gentiobiose, gentiotriose, gentiotetraose and the like), provided comprising an active dental Substance and at least Sorbose, nigero-oligosaccharides, palatinose oligosaccha one natural and/or synthetic high-potency Sweetener in rides, fucose, fructooligosaccharides (kestose, nystose and combination with at least one Sweet taste improving polyol the like), maltotetraol, maltotriol, malto-oligosaccharides additive and at least one Sweet taste improving polyamino (maltotriose, maltotetraose, maltopentaose, maltohexaose, acid additive; wherein the at least one polyol additive is maltoheptaose and the like), lactulose, melibiose, raffinose, chosen from erythritol, maltitol, mannitol, sorbitol, lactitol, rhamnose, ribose, isomerized liquid Sugars such as high Xylitol, inositol, isomalt, propylene glycol, glycerol (glyc fructose corn/starch syrup (e.g., HFCS55, HFCS42, erin), threitol, galactitol, palatinose, reduced isomalto-oli HFCS90), coupling Sugars, soybean oligosaccharides, or gosaccharides, reduced Xylo-oligosaccharides, reduced gen glucose syrup; and wherein the at least one inorganic salt tio-oligosaccharides, reduced maltose syrup, or reduced additive is chosen from sodium chloride, potassium chlo glucose syrup; and wherein the at least one polyamino acid ride, Sodium dihydrogen phosphate, sodium Sulfate, potas additive is chosen from poly-L-aspartic acid, poly-L-lysine sium citrate, europium chloride (EuCls), gadolinium chlo (e.g., poly-L-C-lysine or poly-L-e-lysine), poly-L-Omithine ride (GdCl), terbium chloride (TbCl), magnesium (e.g., poly-L-O-ornithine or poly-L-e-ornithine), poly-L- phosphate, magnesium sulfate, alum, magnesium chloride, arginine, and other polymeric forms of amino acids, or salts mono-, di-, tri-basic sodium or potassium salts of phosphoric thereof. acid, salts of hydrochloric acid, Sodium carbonate, or 0818. In another embodiment, a dental composition is Sodium bicarbonate. provided comprising an active dental Substance and at least 0816. In another embodiment, a dental composition is one natural and/or synthetic high-potency Sweetener in provided comprising an active dental Substance and at least combination with at least one Sweet taste improving protein one natural and/or synthetic high-potency Sweetener in or protein hydrolysate additive and at least one Sweet taste combination with at least one Sweet taste improving carbo improving inorganic salt additive; wherein the at least one hydrate additive, at least one Sweet taste improving amino Sweet taste improving protein or protein hydrolysate addi acid additive, and at least one Sweet taste improving inor tive is chosen from bovine serum albumin (BSA), whey ganic salt additive; wherein the at least one carbohydrate protein (including fractions or concentrates thereof Such as additive is chosen from tagatose, trehalose, galactose, rham 90% instant whey protein isolate, 34% whey protein, 50% nose, cyclodextrin (e.g., C-cyclodextrin, B-cyclodextrin, and hydrolyzed whey protein, and 80% whey protein concen Y-cyclodextrin), maltodextrin (including resistant maltodex trate), Soluble rice protein, soy protein, protein isolates, trins such as Fibersol-2TM), dextran, sucrose, glucose, ribu protein hydrolysates, reaction products of protein hydroly lose, fructose, threose, arabinose, Xylose, lyxose, allose, sates, glycoproteins, and/or proteoglycans containing amino altrose, mannose, idose, lactose, maltose, invert Sugar, acids (e.g., glycine, alanine, Scrine, threonine, theanine, isotrehalose, neotrehalose, palatinose or isomalitulose, eryth asparagine, glutamine, arginine, Valine, isoleucine, leucine, rose, deoxyribose, gulose, idose, talose, erythrulose, Xylu norvaline, methionine, proline, tyrosine, hydroxyproline, or lose, psicose, turanose, cellobiose, amylopectin, glu the like), collagen (e.g., gelatin), partially hydrolyzed col cosamine, mannosamine, fucose, glucuronic acid, gluconic lagen (e.g., hydrolyzed fish collagen), and collagen hydroly acid, glucono-lactone, abequose, galactosamine, beet oli sates (e.g., porcine collagenhydrolysate); and wherein the at gosaccharides, isomalto-oligosaccharides (isomaltose, iso least one Sweet taste improving inorganic salt additive is maltotriose, panose and the like), Xylo-oligosaccharides chosen from Sodium chloride, potassium chloride, sodium (Xylotriose, Xylobiose and the like), gentio-oligoscaccha Sulfate, potassium citrate, europium chloride (EuCl), gado rides (gentiobiose, gentiotriose, gentiotetraose and the like), linium chloride (GdCl), terbium chloride (TbCl), magne US 2007/01 16831 A1 May 24, 2007 32 sium phosphate, magnesium sulfate, alum, magnesium chlo 0823. In one embodiment, a dental composition compris ride, mono-, di-, tri-basic sodium or potassium salts of ing an active dental Substance and a Sweetener composition phosphoric acid, salts of hydrochloric acid, sodium carbon comprising rebaudioside-A (REBA), stevia, Stevioside, ate, Sodium bisulfate, or sodium bicarbonate. mogroside IV. mogroside V, Luo Han Guo Sweetener, mona tin, curculin, Sucralose, saccharin, cyclamate, aspartame, 0819. In another embodiment, a dental composition is acesulfame potassium or other salts, or neotame, in combi provided comprising an active dental Substance and rebau nation with at least one Sweet taste improving protein or dioside A in combination with at least one natural and/or protein hydrolysate additive and at least one Sweet taste synthetic high-potency Sweetener other than rebaudioside-A improving polyol additive is provided. In a particular and at least one Sweet taste improving composition. embodiment, the at least one Sweet taste improving protein 0820. In another particular embodiment, a dental com or protein hydrolysate additive is present in an amount from position is provided comprising an active dental Substance about 200 ppm to about 50,000 ppm of the composition, and and rebaudioside A in combination with at least one syn at least one Sweet taste improving polyol additive is present thetic high-potency Sweetener, wherein the at least one in an amount from about 400 to about 80,000 ppm of the synthetic high-potency Sweetener functions as a Sweet taste composition. In a still more particular embodiment, the at improving composition. Non-limiting examples of Suitable least one Sweet taste improving protein or protein hydroly Sweet taste improving synthetic Sweetener additives include sate additive is a protein, a hydrolysate, or a reaction product Sucralose, potassium acesulfame, aspartame, alitame, sac of a hydrolysate of proteins containing glycine, alanine, charin, neohesperidin dihydrochalcone, cyclamate, serine, leucine, Valine, isoleucine, proline, or threonine, and neotame, N-N-3-(3-hydroxy-4-methoxyphenyl)propyl)-L- the at least one Sweet taste improving polyol additive is C.-aspartyl-L-phenylalanine 1-methyl ester, N-N-3-(3-hy erythritol. droxy-4-methoxyphenyl)-3-methylbutyl-L-C.-aspartyl-L- 0824. In one embodiment, a dental composition compris phenylalanine 1-methyl ester, N-N-3-(3-methoxy-4- ing an active dental Substance and a Sweetener composition hydroxyphenyl)propyl-L-C.-aspartyl-L-phenylalanine comprising rebaudioside-A (REBA), stevia, Stevioside, 1-methyl ester, salts thereof and the like. mogroside IV. mogroside V, Luo Han Guo Sweetener, mona 0821. In one embodiment, a dental composition compris tin, curculin, Sucralose, saccharin, cyclamate, aspartame, ing an active dental Substance and a Sweetener composition acesulfame potassium or other salts, or neotame, in combi comprising rebaudioside-A (REBA), stevia, Stevioside, nation with at least one Sweet taste improving carbohydrate mogroside IV. mogroside V. Luo Han Guo Sweetener, mona additive is provided. In a particular embodiment the at least tin, curculin, Sucralose, cyclamate, saccharin, aspartame, one Sweet taste improving carbohydrate additive is present acesulfame potassium or other salts, or neotame, in combi in an amount from about 1,000 to about 100,000 ppm of the nation with at least one Sweet taste improving amino acid composition. In a still more particular embodiment, the additive and at least one Sweet taste improving polyol Sweetener composition comprises REBA and glucose, additive is provided. In a particular embodiment, the at least sucrose, HFCS, or D-fructose in an amount from about one Sweet taste improving amino acid additive is present in 10,000 ppm to about 80,000 ppm of the composition. an amount from about 100 ppm to about 25,000 ppm of the 0825. In one embodiment, a dental composition compris composition, and the at least one Sweet taste improving ing an active dental Substance and a Sweetener composition polyol additive is present in an amount from about 400 to comprising rebaudioside-A (EBA), Stevia, Stevioside, about 80,000 ppm of the composition. In a still more mogroside IV. mogroside V, Luo Han Guo Sweetener, mona particular embodiment, the at least one Sweet taste improv tin, curculin, Sucralose, saccharin, cyclamate, aspartame, ing amino acid additive is glycine or alanine, and the at least acesulfame potassium or other salts, or neotame, in combi one Sweet taste improving polyol additive is erythritol. nation with at least one Sweet taste improving polyol addi tive is provided. In a particular embodiment, the at least one 0822. In one embodiment, a dental composition compris Sweet taste improving polyol additive is present in an ing an active dental Substance and a Sweetener composition amount from about 400 to about 80,000 ppm of the com comprising rebaudioside-A (REBA), stevia, Stevioside, position. In another particular embodiment, the at least one mogroside IV. mogroside V. Luo Han Guo Sweetener, mona Sweet taste improving polyol additive is present in an tin, curculin, Sucralose, saccharin, cyclamate, aspartame, amount from about 5,000 to about 60,000 ppm of the acesulfame potassium or other salts, or neotame, in combi composition. Non-limiting examples include an active den nation with at least one Sweet taste improving amino acid additive and at least one Sweet taste improving protein or tal Substance and a Sweetener composition comprising protein hydrolysate additive is provided. In a particular rebaudioside-A (REBA), stevia, stevioside, mogroside IV. embodiment, the at least one Sweet taste improving amino mogroside V. Luo Han Guo Sweetener, monatin, curculin, acid additive is present in an amount from about 100 to Sucralose, Saccharin, cyclamate, aspartame, acesulfame about 25,000 ppm of the composition, and the at least one potassium or other salts, or neotame, in combination with Sweet taste improving protein or protein hydrolysate addi propylene glycol, erythritol, or combinations thereof. tive is present in an amount from about 200 ppm to about 0826. In one embodiment, a dental composition compris 50,000 ppm of the composition. In a still more particular ing an active dental Substance and a Sweetener composition embodiment, the at least one Sweet taste improving amino comprising rebaudioside-A (REBA) (with at least 50% acid additive is glycine or lysine, and the at least one Sweet REBA in a steviol glycoside mixture) in combination with at taste improving protein or protein hydrolysate additive is a least one Sweet taste improving polyol additive is provided. protein, a hydrolysate, or a reaction product of a hydrolysate Desirably, the at least one Sweet taste improving polyol of a protein containing glycine, alanine, serine, leucine, additive comprises erythritol. In a particular embodiment of valine, isoleucine, proline, or threonine. the Sweetener composition, rebaudioside A is present in an US 2007/01 16831 A1 May 24, 2007

amount from about 100 to about 3,000 ppm and the eryth curculin, Sucralose, saccharin, cyclamate, aspartame, ritol is present in an amount from about 400 to about 80,000 acesulfame potassium or other salts, or neotame, in combi ppm of the total Sweetener composition. In another embodi nation with NaCl, KC1, NaHSOHO, NaH2PO, MgSO, ment of the Sweetener composition, rebaudioside A is KAl(SO), (alum), magnesium phosphate, magnesium chlo present in an amount from about 100 to about 3,000 ppm and ride, KCl and KHPO, or other combinations thereof. A the erythritol is present in an amount from about 5,000 to particularly desirable embodiment comprises the an active about 40,000 ppm of the total sweetener composition. In still dental Substance and a Sweetener composition comprising another embodiment of the Sweetener composition, rebau rebaudioside-A (REBA), stevia, stevioside, mogroside IV. dioside A is present in an amount from about 100 to about mogroside V. Luo Han Guo Sweetener, monatin, curculin, 3,000 ppm and the erythritol is present in an amount from Sucralose, Saccharin, cyclamate, aspartame, acesulfame about 10,000 to about 35,000 ppm of the total sweetener potassium or other salts, or neotame, in combination with a composition. In another particular embodiment of the Sweet mixture of inorganic salt additives, such as chlorides, phos ener composition, rebaudioside A and erythritol are present phates, and Sulfates of sodium, magnesium, potassium, and in the Sweetener composition in a ratio from about 1:4 to calcium (e.g., sodium chloride and potassium chloride; about 1:800, respectively. In yet another particular embodi potassium phosphate and potassium chloride; sodium chlo ment of the Sweetener composition, rebaudioside A and ride and sodium phosphate, calcium phosphate and calcium erythritol are present in the Sweetener composition in a ratio Sulfate; magnesium chloride and magnesium phosphate; and from about 1:20 to about 1:600, respectively; more particu calcium phosphate, calcium Sulfate, and potassium Sulfate). larly from about 1:50 to about 1:300; and still more par 0830. In a particular embodiment, a dental composition ticularly from about 1:75 to about 1:150. comprising an active dental Substance and a Sweetener 0827. In another embodiment, a dental composition com composition comprises aspartame, acesfulame potassium or prising an active dental Substance and a Sweetener compo other salts, and Sucralose in combination with at least one sition comprising rebaudioside-A (REBA), Stevia, Stevio Sweet taste improving inorganic salt additive. In a particular side, mogroside IV. mogroside V, Luo Han Guo Sweetener, embodiment, the at least one Sweet taste improving inor monatin, or curculin, in combination with at least one Sweet ganic salt additive is present in an amount in the range of taste improving synthetic Sweetener additive is provided. In about 25 to about 5,000 ppm of the composition. Non a particular embodiment, the dental composition comprises limiting examples include an active dental Substance and a an active dental Substance and a Sweetener comprising Sweetener composition comprising aspartame, acesulfame rebaudioside-A (REBA) in combination with saccharin or potassium, and Sucralose in combination with magnesium acesulfame potassium or other salts in an amount from about chloride; an active dental Substance and a Sweetener com 10 ppm to about 100 ppm of the composition. position comprising aspartame, acesulfame potassium, and 0828. In one embodiment, a dental composition compris Sucralose in combination with magnesium sulfate; or an ing an active dental Substance and a Sweetener composition active dental Substance and a Sweetener composition com comprising rebaudioside-A (REBA), stevia, Stevioside, prising aspartame, acesulfame potassium, and Sucralose in mogroside IV. mogroside V. Luo Han Guo Sweetener, mona combination with magnesium sulfate and sodium chloride. tin, curculin, Sucralose, saccharin, cyclamate, aspartame, 0831. In one embodiment, a dental composition compris acesulfame potassium or other salts, or neotame, in combi ing an active dental Substance and a Sweetener composition nation with at least one Sweet taste improving carbohydrate comprising rebaudioside-A (REBA), stevia, Stevioside, additive and at least one Sweet taste improving polyol mogroside IV. mogroside V, Luo Han Guo Sweetener, mona additive is provided. In a particular embodiment, the at least tin, curculin, Sucralose, saccharin, cyclamate, aspartame, one Sweet taste improving carbohydrate additive is present acesulfame potassium or other salts, or neotame, in combi in an amount from about 1,000 to about 100,000 ppm of the nation with at least one Sweet taste improving organic acid composition and at least one Sweet taste improving polyol salt additive is provided. Non-limiting examples include an additive is present in an amount from about 400 to about active dental Substance and a Sweetener composition com 80,000 ppm of the composition. Non-limiting examples prising rebaudioside-A (REBA), Stevia, Stevioside, mogro include an active dental Substance and a Sweetener compo side IV. mogroside V, Luo Han Guo Sweetener, monatin, sition comprising rebaudioside-A (REBA), Stevia, Stevio curculin, Sucralose, saccharin, cyclamate, aspartame, side, mogroside IV. mogroside V, Luo Han Guo Sweetener, acesulfame potassium or other salts, or neotame, in combi monatin, curculin, Sucralose, Saccharin, cyclamate, aspar nation with choline chloride in citrate buffer, D-gluconic tame, acesulfame potassium or other salts, or neotame, in acid sodium salt, guanidine HCl, D-glucosamine HCl, combination with tagatose, fructose or Sucrose and erythri amiloride HCl, or combinations thereof. tol. 0832. In one embodiment, a dental composition compris 0829. In one embodiment, a dental composition compris ing an active dental Substance and a Sweetener composition ing an active dental Substance and a Sweetener composition comprising rebaudioside-A (REBA), stevia, Stevioside, comprising rebaudioside-A (REBA), stevia, Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweetener, mona mogroside IV. mogroside V. Luo Han Guo Sweetener, mona tin, curculin, Sucralose, saccharin, cyclamate, aspartame, tin, curculin, Sucralose, saccharin, cyclamate, aspartame, acesulfame potassium or other salts, or neotame, in combi acesulfame potassium or other salts, or neotame, in combi nation with at least one Sweet taste improving organic acid nation with at least one Sweet taste improving inorganic salt additive is provided. Non-limiting examples include an additive is provided. Non-limiting examples include an active dental Substance and a Sweetener composition com active dental Substance and a Sweetener composition com prising rebaudioside-A (REBA), Stevia, Stevioside, mogro prising rebaudioside-A (REBA), Stevia, Stevioside, mogro side IV. mogroside V, Luo Han Guo Sweetener, monatin, side IV. mogroside V, Luo Han Guo Sweetener, monatin, curculin, Sucralose, saccharin, cyclamate, aspartame, US 2007/01 16831 A1 May 24, 2007 34 acesulfame potassium or other salts, or neotame, in combi tin, curculin, Sucralose, saccharin, cyclamate, aspartame, nation with fumaric acid, malic acid, tartaric acid, citric acid, acesulfame potassium or other salts, or neotame, in combi adipic acid, ascorbic acid, tannic acid, Succinic acid, glutaric nation with at least one Sweet taste improving polymer acid, or combinations thereof. additive and at least one Sweet taste improving polyol additive is provided. In a particular embodiment, the at least 0833. In one embodiment, a dental composition compris one Sweet taste improving polymer additive is present in an ing an active dental Substance and a Sweetener composition amount from about 30 to about 2,000 ppm of the composi comprising rebaudioside-A (REBA), stevia, Stevioside, tion, and the at least one Sweet taste improving polyol mogroside IV. mogroside V. Luo Han Guo Sweetener, mona additive is present in an amount from about 400 to about tin, curculin, Sucralose, saccharin, cyclamate, aspartame, 80,000 ppm of the composition. Non-limiting examples acesulfame potassium or other salts, or neotame, in combi include an active dental Substance and a Sweetener compo nation with at least one Sweet taste improving amino acid sition comprising rebaudioside-A (REBA), Stevia, Stevio additive is provided. In a particular embodiment, the at least side, mogroside IV. mogroside V, Luo Han Guo Sweetener, one Sweet taste improving amino acid additive is present in monatin, curculin, Sucralose, Saccharin, cyclamate, aspar an amount from about 100 to about 25,000 ppm of the tame, acesulfame potassium or other salts, or neotame, in composition. Non-limiting examples include an active den combination with a hydrocolloid, such as a gum acacia tal Substance and a Sweetener composition comprising seyal, and erythritol. rebaudioside-A (REBA), stevia, stevioside, mogroside IV. mogroside V. Luo Han Guo Sweetener, monatin, curculin, 0837. In one embodiment, a dental composition compris Sucralose, Saccharin, cyclamate, aspartame, acesulfame ing an active dental Substance and a Sweetener composition potassium or other salts, or neotame, in combination with comprising rebaudioside-A (REBA), stevia, Stevioside, glycine, L-alanine, L-serine, L-threonine, B-alanine, ami mogroside IV. mogroside V, Luo Han Guo Sweetener, mona nobutyric acid (alpha-, beta-, or gamma-isomers), L-aspartic tin, curculin, Sucralose, saccharin, cyclamate, aspartame, acid, L-glutamic acid, L-lysine, glycine and L-alanine mix acesulfame potassium or other salts, or neotame, in combi nation with at least one Sweet taste improving protein or ture, salt derivatives or combinations thereof. protein hydrolysate additive is provided. Non-limiting 0834. In one embodiment, a dental composition compris examples include an active dental Substance and a Sweetener ing an active dental Substance and a Sweetener composition composition comprising rebaudioside-A (REBA), Stevia, comprising rebaudioside-A (REBA), stevia, Stevioside, Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet mogroside IV, mogroside V, Luo Han Guo Sweetener, mona ener, monatin, curculin, Sucralose, Saccharin, cyclamate, tin, curculin, Sucralose, saccharin, cyclamate, aspartame, aspartame, acesulfame potassium or other salts, or neotame, acesulfame potassium or other salts, or neotame, in combi in combination with bovine serum albumin (BSA), whey nation with at least one Sweet taste improving Surfactant protein or combinations thereof. additive is provided. Non-limiting examples include an 0838. In one embodiment, a dental composition compris active dental Substance and a Sweetener composition com ing an active dental Substance and a Sweetener composition prising rebaudioside-A (REBA), Stevia, Stevioside, mogro comprising rebaudioside-A (REBA), stevia, Stevioside, side IV. mogroside V, Luo Han Guo Sweetener, monatin, mogroside IV. mogroside V, Luo Han Guo Sweetener, mona curculin, Sucralose, saccharin, cyclamate, aspartame, tin, curculin, Sucralose, saccharin, cyclamate, aspartame, acesulfame potassium or other salts, or neotame, in combi acesulfame potassium or other salts, or neotame, in combi nation with dioctyl sulfo Succinate sodium, cetylpyridinium nation with at least one Sweet taste improving amino acid chloride, hexadecyltrimethylammonium bromide, Sucrose additive and at least one Sweet taste improving inorganic oleate, polysorbate 20, polysorbate 80, lecithin, or combi acid salt additive is provided. In a particular embodiment, nations thereof. the at least one Sweet taste improving amino acid additive is 0835. In one embodiment, a dental composition compris present in an amount from about 100 to about 25,000 ppm ing an active dental Substance and a Sweetener composition of the composition and the at least one Sweet taste improving comprising rebaudioside-A (REBA), stevia, Stevioside, inorganic acid salt additive is present in an amount from mogroside IV. mogroside V. Luo Han Guo Sweetener, mona about 25 to about 5,000 ppm of the composition. Non tin, curculin, Sucralose, saccharin, cyclamate, aspartame, limiting examples include an active dental Substance and a acesulfame potassium or other salts, or neotame, in combi Sweetener composition comprising rebaudioside-A (REBA), nation with at least one Sweet taste improving polymer Stevia, Stevioside, mogroside TV, mogroside V, Luo Han additive is provided. Non-limiting examples include an Guo Sweetener, monatin, curculin, Sucralose, Saccharin, active dental Substance and a Sweetener composition com cyclamate, aspartame, acesulfame potassium or other salts, prising rebaudioside-A (REBA), Stevia, Stevioside, mogro or neotame, in combination with glycine and alum; an active side IV. mogroside V, Luo Han Guo Sweetener, monatin, dental Substance and a Sweetener composition comprising curculin, Sucralose, saccharin, cyclamate, aspartame, rebaudioside-A (REBA), stevia, stevioside, mogroside IV. acesulfame potassium or other salts, or neotame, in combi mogroside V. Luo Han Guo Sweetener, monatin, curculin, nation with cationic polymer Such as polyethyleneimine, Sucralose, Saccharin, cyclamate, aspartame, acesulfame poly-L-tysine (e.g., poly-L-C-lysine or poly-L-e-lysine), potassium or other salts, or neotame, in combination with polyornithine (e.g., poly-L-O-ornithine or poly-e-omithine), glycine and potassium chloride; an active dental Substance and a Sweetener composition comprising rebaudioside-A chitosan, or combinations thereof. (REBA), stevia, stevioside, mogroside IV. mogroside V. Luo 0836. In one embodiment, a dental composition compris Han Guo Sweetener, monatin, curculin, Sucralose, Saccharin, ing an active dental Substance and a Sweetener composition cyclamate, aspartame, acesulfame potassium or other salts, comprising rebaudioside-A (REBA), stevia, Stevioside, or neotame, in combination with glycine and Sodium chlo mogroside IV. mogroside V. Luo Han Guo Sweetener, mona ride; an active dental Substance and a Sweetener composition US 2007/01 16831 A1 May 24, 2007

comprising REBA in combination with glycine, potassium side IV. mogroside V, Luo Han Guo Sweetener, monatin, dihydrogen phosphate, and potassium chloride; and rebau curculin, Sucralose, saccharin, cyclamate, aspartame, dioside-A (REBA), stevia, Stevioside, morgroside IV, mor acesulfame potassium or other salts, or neotame, in combi groside V. Lo Han Guo, monatin, curculin, Sucralose, sac nation with urea and sodium chloride. charin, aspartame, acesulfame potassium or other salts, or 0841. In another embodiment, a dental composition com neotame, in combination with glycine, Sodium chloride, and prising an active dental Substance and a Sweetener compo potassium chloride. sition comprising rebaudioside-A (REBA), Stevia, Stevio 0839. In another embodiment, a dental composition com side, mogroside IV. mogroside V, Luo Han Guo Sweetener, prising an active dental Substance and a Sweetener compo monatin, curculin, Sucralose, Saccharin, cyclamate, aspar sition comprising rebaudioside-A (REBA), Stevia, Stevio tame, acesulfame potassium or other salts, or neotame, in side, mogroside IV. mogroside V, Luo Han Guo Sweetener, combination with at least one Sweet taste improving amino monatin, curculin, Sucralose, Saccharin, cyclamate, aspar acid additive and at least one Sweet taste improving tame, acesulfame potassium or other salts, or neotame, in polyamino acid additive is provided. In a particular embodi combination with at least one Sweet taste improving carbo ment, the at least one Sweet taste improving amino acid hydrate additive and at least one Sweet taste improving additive is present in an amount from about 100 to about inorganic acid salt additive is provided. In a particular 25,000 ppm of the composition and the at least one sweet embodiment, the at least one Sweet taste improving carbo taste improving polyamino acid additive is present in an hydrate additive is present in an amount from about 1,000 to amount from about 30 to about 2,000 ppm of the composi about 100,000 ppm of the composition and the at least one tion. Non-limiting examples include an active dental Sub Sweet taste improving inorganic acid salt additive is present stance and a Sweetener composition comprising rebaudio in an amount from about 25 ppm to about 5,000 ppm. side-A (REBA), stevia, Stevioside, mogroside IV. mogroside Non-limiting examples include an active dental Substance V. Luo Han Guo Sweetener, monatin, cureulin, Sucralose, and a Sweetener composition comprising rebaudioside-A saccharin, cyclamate, aspartame, acesulfame potassium or (REBA), stevia, stevioside, mogroside IV. mogroside V. Luo other salts, or neotame, in combination with glycine and Han Guo Sweetener, monatin, curculin, Sucralose, Saccharin, poly-C-L-lysine; and an active dental Substance and a Sweet cyclamate, aspartame, acesulfame potassium or other salts, ener composition comprising rebaudioside-A (REBA), Ste or neotame, in combination with fructose. Sucrose, or glu via, Stevioside, mogroside IV. mogroside V, Luo Han Guo cose and alum; an active dental Substance and a Sweetener Sweetener, monatin, curculin, Sucralose, Saccharin, cycla composition comprising rebaudioside-A (REBA), Stevia, mate, aspartame, acesulfame potassium or other salts, or Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet neotame, in combination with glycine and poly-e-L-lysine. ener, monatin, curculin, Sucralose, saccharin, cyclamate, aspartame, acesulfame potassium or other salts, or neotame, 0842) In another embodiment, a dental composition com in combination with fructose, Sucrose, or glucose and potas prising an active dental Substance and a Sweetener compo sium chloride; an active dental Substance and a Sweetener sition comprising rebaudioside-A (REBA), Stevia, Stevio composition comprising rebaudioside-A (REBA), Stevia, side, mogroside IV. mogroside V, Luo Han Guo Sweetener, Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet monatin, curculin, Sueralose, Saccharin, cyclamate, aspar ener, monatin, curculin, Sucralose, saccharin, cyclamate, tame, acesulfame potassium or other salts, or neotame, in aspartame, acesulfame potassium or other salts, or neotame, combination with at least one Sweet taste improving amino in combination with fructose. Sucrose, or glucose and acid additive and at least one Sweet taste improving organic Sodium chloride; an active dental Substance and a Sweetener acid additive is provided. In a particular embodiment, the at composition comprising rebaudioside-A (REBA), Stevia, least one Sweet taste improving amino acid additive is Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet present in an amount from about 100 to about 25,000 ppm ener, monatin, curculin, Sucralose, saccharin, cyclamate, of the composition and the at least one Sweet taste improving aspartame, acesulfame potassium or other salts, or neotame, organic acid additive is present in an amount from about 10 in combination with fructose, Sucrose, or glucose, potassium to about 5,000 ppm of the composition. A non-limiting phosphate, and potassium chloride; and an active dental example includes an active dental Substance and a Sweetener Substance and a Sweetener composition comprising rebau composition comprising rebaudioside-A (REBA), Stevia, dioside-A (REBA), stevia, Stevioside, mogroside IV. mogro Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet side V, Luo Han Guo Sweetener, monatin, curculin, Sucral ener, monatin, curculin, Sucralose, saccharin, cyclamate, ose, Saccharin, cyclamate, aspartame, acesulfame potassium aspartame, acesulfame potassium or other salts, or neotame, or other salts, or neotame, in combination with fructose, in combination with glycine and sodium gluconate. Sucrose, or glucose, sodium chloride, and potassium chlo 0843. In another embodiment, a dental composition com ride. prising an active dental Substance and a Sweetener compo 0840. In another embodiment, a dental composition com sition comprising rebaudioside-A (REBA), Stevia, Stevio prising an active dental Substance and a Sweetener compo side, mogroside IV. mogroside V, Luo Han Guo Sweetener, sition comprising rebaudioside-A (REBA), Stevia, Stevio monatin, curculin, Sucralose, Saccharin, cyclamate, aspar side, mogroside IV. mogroside V, Luo Han Guo Sweetener, tame, acesulfame potassium or other salts, or neotame, in monatin, curculin, Sucralose, Saccharin, cyclamate, aspar combination with at least one Sweet taste improving amino tame, acesulfame potassium or other salts, or neotame, in acid additive and at least one Sweet taste improving carbo combination with at least one Sweet taste improving bitter hydrate additive is provided. In a particular embodiment, the additive and at least one Sweet taste improving inorganic salt at least one Sweet taste improving amino acid additive is additive is provided. A non-limiting example include an present in an amount from about 100 to about 25,000 ppm active dental Substance and a Sweetener composition com of the composition and the at least one Sweet taste improving prising rebaudioside-A (REBA), Stevia, Stevioside, mogro carbohydrate additive is present in an amount from about US 2007/01 16831 A1 May 24, 2007 36

15000 to about 100,000 ppm of the composition. A non monatin, curculin, Sucralose, Saccharin, cyclamate, aspar limiting example includes an active dental Substance and a tame, acesulfame potassium or other salts, or neotame, in Sweetener composition comprising rebaudioside-A (REBA), combination with at least one Sweet taste improving amino Stevia, Stevioside, mogroside IV, mogroside V, Luo Han Guo acid additive, at least one Sweet taste improving polyol Sweetener, monatin, curculin, Sucralose, saccharin, cycla additive, and at least one Sweet taste improving inorganic mate, aspartame, acesulfame potassium or other salts, or acid salt additive is provided. In a particular embodiment, neotame, in combination with L-alanine and fructose. the at least one Sweet taste improving amino acid additive is 0844. In another embodiment, a dental composition com present in an amount from about 100 to about 25,000 ppm prising an active dental Substance and a Sweetener compo of the composition, the at least one Sweet taste improving sition comprising rebaudioside-A (REBA), Stevia, Stevio polyol additive is present in an amount from about 400 to side, mogroside IV. mogroside V, Luo Han Guo Sweetener, about 80,000 ppm of the composition, and the at least one monatin, curculin, Sucralose, Saccharin, cyclamate, aspar Sweet taste improving inorganic acid salt additive is present tame, acesulfame potassium or other salts, or neotame, in in an amount from about 25 to about 5,000 ppm of the combination with at least one Sweet taste improving amino composition. A non-limiting example includes an active acid additive, at least one Sweet taste improving polyol dental Substance and a Sweetener composition comprising additive, at least one Sweet taste improving inorganic salt rebaudioside-A (REBA), stevia, stevioside, mogroside IV. additive, and at least one Sweet taste improving organic acid mogroside V. Luo Han Guo Sweetener, monatin, curculin, salt additive is provided. In a particular embodiment, the at Sucralose, Saccharin, cyclamate, aspartame, acesulfame least one Sweet taste improving amino acid additive is potassium or other salts, or neotame, in combination with present in an amount from about 100 to about 25,000 ppm erythritol, glycine, KC1, and KHPO. of the composition, the at least one Sweet taste improving 0847. In another embodiment, a dental composition com polyol additive is present in an amount from about 400 to prising an active dental Substance and a Sweetener compo about 80,000 ppm of the composition, the at least one sweet sition comprising rebaudioside-A (REBA), Stevia, Stevio taste improving inorganic salt additive is present in an side, mogroside IV. mogroside V, Luo Han Guo Sweetener, amount from about 25 to about 5,000 ppm of the composi monatin, curculin, glycyrrihizin such as mono-ammonium tion, and the at least one Sweet taste improving organic acid glycyrrhizic acid salt hydrate. Sucralose, Saccharin, cycla salt additive is present in an amount from about 25 to about mate, aspartame, acesulfame potassium or other salts, or 5,000 ppm of the composition. A non-limiting example neotame, in combination with a Sweet taste improving includes an active dental substance and a Sweetener com inorganic acid salt additive is provided. A non-limiting position comprising rebaudioside-A (REBA), Stevia, Stevio example includes an active dental Substance and a Sweetener side, mogroside IV. mogroside V, Luo Han Guo Sweetener, composition comprising rebaudioside-A (REBA), Stevia, monatin, curculin, Sucralose, Saccharin, cyclamate, aspar Stevioside, mogroside IV. mogroside V, Luo Han Guo Sweet tame, acesulfame potassium or other salts, or neotame, in ener, monatin, curculin, glycyrrihizin such as mono-ammo combination with erythritol, glycine, KC1, KHPO, and nium glycyrrhizic acid salt hydrate. Sucralose, Saccharin, choline chloride. cyclamate, aspartame, acesulfame potassium or other salts, or neotame, in combination with sodium chloride. 0845. In another embodiment, a dental composition com prising an active dental Substance and a Sweetener compo 0848 The desired weight ratio of the natural and/or sition comprising rebaudioside-A (REBA), Stevia, Stevio synthetic high-potency Sweetener to Sweet taste improving side, mogroside IV. mogroside V, Luo Han Guo Sweetener, composition(s) in the Sweetener composition will depend on monatin, curculin, Sucralose, Saccharin, cyclamate, aspar the particular natural and/or synthetic high-potency Sweet tame, acesulfame potassium or other salts, or neotame, in ener, and the Sweetness and other characteristics desired in combination with at least one Sweet taste improving amino the final product. Natural and/or synthetic high-potency acid additive, at least one Sweet taste improving carbohy Sweeteners vary greatly in their potency, ranging from about drate additive, and at least one Sweet taste improving polyol 30 times more potent than sucrose to about 8,000 times more additive is provided. In a particular embodiment, the at least potent than Sucrose on a weight basis. In general, the weight one Sweet taste improving amino acid additive is present in ratio of the natural and/or synthetic high-potency Sweetener an amount from about 100 to about 25,000 ppm of the to Sweet taste improving composition may for example composition, the at least one Sweet taste improving carbo range from range between 10,000:1 and 1:10,000; a further hydrate additive is present in an amount from about 1,000 to non-limiting example may range from about 9,000:1 to about 100,000 ppm of the composition, and the at least one about 1:9,000; yet another example may range from about Sweet taste improving polyol additive is present in an 8,000:1 to about 1:8,000; a farther example may range from amount from about 400 to about 80,000 ppm of the com about 7,000:1 to about 1:7,000; another example may range position. A non-limiting example includes an active dental from about 6,000:1 to about 1:6000; in yet another example Substance and a Sweetener composition comprising rebau may range from about 5,000:1 to about 1:5,000; in yet dioside-A (REBA), stevia, Stevioside, mogroside IV. mogro another example may range from about 4,000:1 to about side V, Luo Han Guo Sweetener, monatin, curculin, Sucral 1:4,000; in yet another example may range from about ose, Saccharin, cyclamate, aspartame, acesulfame potassium 3,000:1 to about 1:3,000; in yet another example may range from about 2,000:1 to about 1:2,000; in yet another example or other salts, or neotame, in combination with L-alanine, may range from about 1,500:1 to about 1: 1,500; in yet fructose, and erythritol. another example may range from about 1,000:1 to about 0846. In another embodiment, a dental composition com 1:1,000; in yet another example may range from about 900:1 prising an active dental Substance and a Sweetener compo to about 1:900; in yet another example may range from sition comprising rebaudioside-A (REBA), Stevia, Stevio about 800:1 to about 1:800; in yet another example may side, mogroside IV. mogroside V, Luo Han Guo Sweetener, range from about 700:1 to about 1:700; in yet another US 2007/01 16831 A1 May 24, 2007 37 example may range from about 600:1 to about 1:600; in yet pure, diluted, or concentrated form as a liquid (e.g., solu another example may range from about 500:1 to about tion), Solid (e.g., powder, chunk, pellet, grain, block, crys 1:500; in yet another example may range from about 400:1 talline, or the like), Suspension, gas state, or combinations to about 1:400; in yet another example may range from thereof before both are contacted with a Sweetenble com about 300:1 to about 1:300; in yet another example may position. In yet another embodiment, when there are more range from about 200:1 to about 1:200; in yet another than one natural and/or synthetic high-potency Sweeteners or example may range from about 150:1 to about 1:150; in yet more than one Sweet taste improving composition in the another example may range from about 100:1 to about Sweeteneable composition, each component of the Sweeten 1:100; in yet another example may range from about 90:1 to able composition may be added simultaneously, in an alter about 1:90; in yet another example may range from about nating pattern, in a random pattern, or any other pattern. 80:1 to about 1:80; in yet another example may range from about 70:1 to about 1:70; in yet another example may range 0852 Generally, the amount of natural and/or synthetic from about 60:1 to about 1:60; in yet another example may high-potency Sweetener present in a Sweetened composition range from about 50:1 to about 1:50; in yet another example varies widely depending on the desired sweetness. Those of may range from about 40:1 to about 1:40; in yet another ordinary skill in the art can readily discern the appropriate example may range from about 30:1 to about 1:30; in yet amount of Sweetener to put in the Sweetened composition. In another example may range from about 20:1 to about 1:20; a particular embodiment, the at least one natural and/or in yet another example may range from about 15:1 to about synthetic high-potency Sweetener is present in the Sweetened 1:15; in yet another example may range from about 10:1 to composition in an amount in the range of about 1 to about about 1:10; in yet another example may range from about 5,000 ppm of the Sweetened composition and the at least one 9:1 to about 1:9; in yet another example may range from Sweet taste improving composition is present in the Sweet about 8:1 to about 1:8; in yet another example may range ened composition in an amount in the range of about 0.1 to from about 7:1 to about 1:7; in yet another example may about 100,000 ppm of the sweetened composition. range from about 6:1 to about 1:6; in yet another example 0853. In accordance with particular embodiments, suit may range from about 5:1 to about 1:5; in yet another able amounts of natural high-potency Sweeteners for Sweet example may range from about 4:1 to about 1:4; in yet ened compositions comprise amounts in the range from another example may range from about 3:1 to about 1:3; in about 100 ppm to about 3,000 ppm for rebaudioside A: from yet another example may range from about 2:1 to about 1:2: about 50 ppm to about 3,000 ppm for stevia; from about 50 and in yet another example may be about 1:1; depending on ppm to about 3,000 ppm for stevioside; from about 50 ppm the particular natural and/or synthetic high-potency Sweet to about 3,000 ppm for mogroside IV: from about 50 ppm to ener selected. about 3,000 ppm for mogroside V: from about 50 ppm to 0849. It is contemplated that the combination of at least about 3,000 ppm for Luo Han Guo Sweetener; from about 5 one natural and/or synthetic high-potency Sweetener to at ppm to about 300 ppm for monatin, from about 5 ppm to least one Sweet taste improving composition may be carried about 200 ppm for thaumatin; and from about 50 ppm to out in any pH range that does not materially or adversely about 3,000 ppm for mono-ammonium glycyrrhizic acid salt affect the taste of the Sweetener composition. A non-limiting hydrate. example of the pH range may be from about 2 to about 8. A 0854. In accordance with particular embodiments, suit further example includes a pH range from about 2 to about able amounts of synthetic high-potency Sweeteners for 5. Sweetened compositions comprise a range from about 1 ppm to about 60 ppm foralitame; from about 10 ppm to about 600 0850. One of ordinary skill in the art may combine at ppm for aspartame; from about 1 ppm to about 20 ppm for least one natural and/or synthetic high-potency Sweetener, at neotame; from about 10 ppm to about 500 ppm for least one Sweet taste improving composition, and Sweet acesulfame potassium; from about 50 ppm to about 5,000 enble composition in any manner. For example, at least one ppm for cyclamate; from about 10 ppm to about 500 ppm for natural and/or synthetic high-potency Sweetener may be saccharin; from about 5 ppm to about 250 ppm for sucralose; added to the Sweetenble composition before the at least one from about 1 ppm to about 20 ppm for N-N-3-(3-hydroxy Sweet taste improving composition. In another example, at 4-methoxyphenyl)propyl-L-C.-aspartyl-L-phenylalanine least one natural and/or synthetic high-potency Sweetener 1-methyl ester; from about 1 ppm to about 20 ppm for may be added to the Sweetenble composition after the at N-N-3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl-L- least one Sweet taste improving composition. In yet another C.-aspartyl-L-phenylalanine 1-methyl ester, and from about example, at least one natural and/or synthetic high-potency 1 ppm to about 20 ppm for N-N-3-(3-methoxy-4-hydrox sweetener may be added to the Sweetenble composition yphenyl)propyl-L-C.-aspartyl-L-phenylalanine 1-methyl simultaneously with the at least one Sweet taste improving composition. ester. 0851. In yet another embodiment, at least one natural V. Dental Composition Formulations and Methods and/or synthetic high-potency Sweetener may be combined 0855. The dental compositions embodied herein may be with the at least one Sweet taste improving composition prior prepared using known techniques. In accordance with par to being added to a Sweetenble composition. For example, ticular embodiments of this invention, dental compositions the at least one natural and/or synthetic high-potency Sweet may be prepared as gels, powders, pastes, putties, Solutions, ener may be in a pure, diluted, or concentrated form as a sprays, or similar type materials known in the art. For liquid (e.g., Solution), Solid (e.g., powder, chunk, pellet, example, in one embodiment, the active dental Substance grain, block, crystalline, or the like), Suspension, gas state, and the base material, including the natural and/or synthetic or combinations thereof may be contacted with the at least high-potency Sweetener and the at least one Sweet taste one Sweet taste improving composition which may be in a improving composition, may be prepared as a paste. The US 2007/01 16831 A1 May 24, 2007

components of the dental composition are both manually the gel, then adding a Surfactant, a flavor and thereafter and mechanically weighed to ensure accuracy in the com degassing the mixture under vacuum. The proportions used ponents’ proportions. The components are then mixed are: baking soda, 32%; chalk, 10%; titanium dioxide, 0.4%; together. In one embodiment, a humectant-water mixture deionized water, 15.4%; glycerol, 33.5%: CMC, 1.1%; solu made first and then the other components are added into the mixture. The temperature and humidity of vat monitored to tion of 35% sodium N-lauryl sarcosinate in a mixture of 35% ensure that the mix comes together correctly to produce the water and 30% glycerol, 2%; sodium lauryl sulfate, 0.98%; dental composition. The dental composition can then be sodium benzoate, 0.5%; rebaudioside A, 0.25%; erythritol, packaged in, for example, a tube or other similar type 3%; flavor, 0.9%. package. 0856 Dental compositions also may comprise agglom Example A2 erated components. Not wishing to be bound by any theory, 0860. An exemplary formula for an enhancing composi it is believed that physical modifications of the natural tion according to the present invention is presented in Table and/or synthetic high-potency Sweetener by agglomeration 2 below. Water is used as the primary carrier and solvent for may slow its release in dental compositions by reducing the the remaining ingredients. Potassium hydroxide is incorpo solubility or dissolution rate of the natural and/or synthetic rated as a peroxide activator and pH modifier. Other optional high-potency Sweetener. Briefly described, agglomerations ingredients which may provide certain functionalities may are prepared by mixing an absorbent with an agglomerating include tartaric acid to adjust the final pH of the enhancing agent in powder form, spraying a solution of the natural composition to a biologically compatible level and hydrogen and/or synthetic high-potency Sweetener onto the powder as peroxide to initiate whitening. Several non-active ingredi mixing continues, removing the powder from the mixer, ents include Pluronic F68 as a gelling agent, sodium lauryl drying to remove the solvent, and grinding to a desired Sulfate as a stain remover, rebaudioside A as a Sweetener, particle size. Desirably, the absorber comprises a silica and Sodium citrate for improved oral sensation, peppermint oil the agglomerating agent comprises a cellulose derivative. for flavor and scent, ethanol as an antibacterial agent, a color Other non-limiting examples of absorbers include silicates, additive for visual interest, and erythritol as the sweet taste maltodextrin, clays, spongelike beads or microbeads, amor improving composition comprises. phous Sugars, amorphous carbonates and hydroxides, veg etable gums, and other spray dried materials. The agglom TABLE 2 erated particles may be added at any point in the dental composition processing methods described above. Ingredient Amount Water 80 ml potassium hydroxide 0.1 g VI. EXAMPLES Pluronic F68 0.5 g. sodium lauryl Sulfate 0.5 g. 0857. The present invention is further illustrated by the rebaudioside A 0.25 g following examples, which are not to be construed in any erythritol 3 g sodium citrate 0.7 g way as imposing limitations upon the scope thereof. On the hydrogen peroxide (30%) 6.7 g contrary, it is to be clearly understood that resort may be had peppermint oil 0.3 g to various other embodiments, modifications, and equiva Ethanol 8.6 g. red color 2 drops lents thereof which, after reading the description therein, tartaric acid 0.1 g may suggest themselves to those skilled in the art without departing from the spirit of the present invention and/or the Scope of the appended claims. Unless otherwise specified, 0861. The ingredients of Table 2 may be mixed according %’s are by weight. to the methods disclosed in U.S. Patent Application Publi cation 2006/0204455, which is hereby incorporated by ref Example Set A erence in its entirety. For example, approximately 0.1 g of potassium hydroxide can be completely dissolved in 60 ml Example A1 of water. The dissolution of potassium hydroxide is an 0858. A dental composition comprises an active dental exothermic process that heats the Solution. Next, approxi Substance, at least one high-potency Sweetener, and at least mately 0.5 g of Pluronic F68 can be dissolved in the one Sweet taste improving composition. The active dental water-potassium hydroxide mixture. The generation of heat Substance comprises baking Soda. The at least one high is advantageous because heat may be beneficial for the potency Sweetener comprises rebaudioside A. The at least dissolution of the Pluronic F68. Application of additional one Sweet taste improving composition comprises erythritol. heat to the mixture may assist in completely dissolving the Pluronic F68. The mixture of water, potassium hydroxide, 0859 More particularly, the dental composition is a and Pluronic F68, which may be referred to as Mixture 1, is toothpaste prepared as a gel by mixing a gelling agent, in this set aside. case sodium carboxymethylcellulose (“CMC), with glyc erol and water in the presence of the high-potency Sweetener 0862. A second mixture, Mixture 2, can be prepared by and a preservative, sodium benzoate, adding Sodium bicar dissolving approximately 0.25 g of rebaudioside A in 20 ml bonate (baking soda), chalk and titanium dioxide powder to of water. Mixture 2 can be completed by dissolving approxi US 2007/01 16831 A1 May 24, 2007 39 mately 0.7 g of sodium citrate and 3 g of erythritol into the Stevioside, 0.03% rebaudioside C, 0.12% rebaudioside F, water-rebaudioside A solution. Mixture 1 can then be com- 0.13% other steviolglycosides, 0.1% rebaudioside D, 0.49% bined with Mixture 2. Next, approximately 6.7 g of 30% rebaudioside B and 0.03% steviolbioside, all by weight. hydrogen peroxide solution can be slowly introduced to the Example B2 combination of Mixture 1 and Mixture 2 to form Mixture 3. Mixture 3 may then be set aside. 0870 Crude rebaudioside A (80.37%) was obtained from a commercial source. The impurities (6.22% stevioside, 0863. Another mixture, Mixture 4, can be created by 2.28% rebaudioside C, 0.35% Dulcoside, 0.78% rebaudio dissolving approximately 0.3 g of peppermint oil in approxi- side F, 0.72% other steviolglycosides, 3.33% rebaudioside mately 8.6 g of ethanol. Several drops of a coloring additive, B, 0.07% steviolbioside) were identified by HPLC on dry for example, food coloring, may be added to Mixture 4 to basis, moisture content 3.4%. provide visual interest to the enhancing composition. In the 0871 Crude rebaudioside A (100 g), ethanol (95%, 320 ingredients depicted in Table 2, approximately two drops of mL), methanol (99%, 120 mL) and water (50 mL) were red coloring may be added to Mixture 4. combined and heated to 30-40°C. for 10 minutes. The clear solution was cooled to 22° C. for 16 hours. The white 0864) Next, Mixture 4 can be slowly added to Mixture 3 crystals were filtered and washed twice with ethanol (2x50 to form Mixture 5. Finally, approximately 0.1 g of tartaric mL. 95%). The wet filter cake (88 g) was slurried in ethanol acid may be added to Mixture 5 to adjust the basic pH of (95%, 1320 mL) for 16 hours, filtered, washed with ethanol Mixture 5 downward to a biologically compatible level, for (95%, 2x100 mL) and dried in a vacuum oven at 60° C. for example, between about 8.5 and 9.5, with a target pH of 16-24 hours under reduced pressure (20 mm) about 8.8. The mixture of the ingredients in Table 2 accord ing to the steps set forth can result in a 100 ml volume of an 0872 The final composition of substantially pure rebau exemplary enhancing composition for pretreatment of den- dioside A (72 g) comprised 98.29% rebaudioside A, 0.03% tition before application of a tooth whitening composition. Stevioside, 0.02% rebaudioside C, 0.17% rebaudioside F, The increase in pH created by the enhancing composition 0.06% rebaudioside D and 1.09% rebaudioside B. Steviol enhances the effectiveness of the tooth whitening com- bioside was not detected by HPLC. pound. Example B3

-E3 1llustratein ES methods of makingAs E.diapurified rebaudios.1de D. ". a0873. commercial Crude source.rebaudioside The Aimpurities (80.37%) (6.22% was obtained stevioside, from in accordance with particular embodiments of this invention: 2.28% rebaudioside C, 0.35% Dulcoside, 0.78% rebaudio side F, 0.72% other steviolglycosides. 3.33% rebaudioside Example Set B B, 0.07% steviolbioside) were identified by HPLC on dry 0866) basis, moisture content 3.4%.

TABLE 3 Summary of Examples B1-3

Crude Solvent HPLC Rebaudioside A Ethanol Methanol Water Heating Drying Yield Purity (g) (95%)(mL) (99%)(mL) (mL) T (- C.) T (- C.) (g) (wt wt %) B1 400 1200 400 32O 50 50 130 98.9 B2 1OO 32O 120 50 30-40 60 72 98.3 B3 50 160 60 25 -30 60 27.3 98.2

Example B1 0874) Crude rebaudioside A (50 g), ethanol (95%, 160 0867 Crude rebaudioside A (77.4% purity) mixture was mL). methanol (99%,O 60 mL) and water (25 mL) were obtained from a commercial source. The impurities (6.2% combined and heated to approximately 30° C. for 10 min Stevioside, 5.6% rebaudioside C, 0.6% rebauiodioside F, utes. The clear solution was cooled to 22° C. for 16 hours. 1.0% other steviolglycosides, 3.0% rebaudioside D, 4.9% The white crystals were filtered and washed twice with rebaudioside B, 0.3% steviolbioside) were identified and ethanol (2x25 mL. 95% ). The wet filter cake (40 g) was quantified using HPLC on dry basis, moisture content 4.7%. slurried in methanol (99%. 600 mL) for 16 hours, filtered, 0868 Crude rebaudioside A (400g), ethanol (95%, 1200 washed with methanol (99%, 2x25 mL) and dried in a mL), methanol (99%, 400 mL) and water (320 mL) were vacuum oven at 60° C. for 16-24 hours under reduced combinedsolution was and cooledheated toto 22°50° C. forfor 1016 minutes.hours. The The whiteclear pressure (20 mm). crystals were filtered and washed twice with ethanol (2x200 0875) The final composition of substantially pure rebau mL. 95%) and dried in a vacuum oven at 50° C. for 16-24 dioside A (27.3 g) comprised 98.22% rebaudioside A, 0.04% hours under reduced pressure (20 mm). Stevioside, 0.04% rebaudioside C, 0.18% rebaudioside F, 0869. The final composition of substantially pure rebau- 0.08% rebaudioside D and 1.03% rebaudioside B. Steviol dioside A (130 g) comprised 98.91% rebaudioside A, 0.06% bioside was not detected by HPLC. US 2007/01 16831 A1 May 24, 2007 40

Example Set C 0876)

TABLE 4 Summary of Examples C1-3

Solvent Crude Organic HPLC Rebaudioside Ethanol Co-solvent Water Yield Purity A (g) (95%)(mL) (mL) (mL) Wash Solvent (g) (%) C1 5 15 Methanol (6) 3.5 EtOHSMeOH 2.6 >99 (3:1 viv) C2 5 15 Methanol (5) 4 EtOHSMeOH 2.3 >99 (3:1 viv) C3 5 16 Methanol (6) 2.5 *EtOHA MeOH 3.2 >98 (8:3 viv)

Example C1 uct was filtered, washed twice with ethanol:methanol (5.0 0877. A mixture of crude rebaudioside A (80.37% purity, mL, 8:3, V/v) mixture and dried in a vacuum oven at 50° C. 5g), ethanol (95%, 15 mL), methanol (5 mL) and water (3.5 for 16-24 hours under reduced pressure (20 mm) to yield 3.2 mL) were combined and heated to reflux for 10 minutes. The g of purified product (>98% by HPLC). clear solution was cooled to 22° C. for 16 hours while Example B stirring. The white crystalline product was filtered, washed twice with ethanol:methanol (5.0 mL, 3:1, v/v) mixture and 0880 dried in a vacuum oven at 50° C. for 16-24 hours under reduced pressure (20 mm) to yield 2.6 g of purified product TABLE 5 (>99% by HPLC). Summary of Example D

Example C2 Solvent 0878. A mixture of crude rebaudioside A (80.37% purity, Crude Organic HPLC 5g), ethanol (95%, 15 mL), methanol (5 mL) and water (4.0 Rebaudioside Solvent Water Wash Yield Purity mL) were combined and heated to reflux for 10 minutes. The A (g) (mL) (mL) Solvent (g) (%) clear solution was cooled to 22° C. for 16 hours while stirring. The white crystalline product was filtered, washed D 50 EtOH (160) 40 EtOH 19.8 99.5 twice with ethanol:methanol (5.0 mL, 3:1, v/v) mixture and dried in a vacuum oven at 50° C. for 16-24 hours under 0881. A mixture of crude rebaudioside A (80.37% purity, reduced pressure (20 mm) to yield 2.3 g of purified product 50 g), ethanol (95%, 160 mL) and water (40 mL) were (>99% by HPLC). combined and heated to reflux for 30 minutes. The mixture was then allowed to cool to ambient temperature for 16-24 Example C3 hours. The white crystalline product was filtered, washed 0879. A mixture of crude rebaudioside A (80.37% purity, twice with ethanol (95%, 25 mL), and dried in a vacuum 5g), ethanol (95%, 16 mL), methanol (6 mL) and water (2.5 oven at 60° C. for 16-24 hours under reduced pressure (20 mL) were combined and heated to reflux for 10 minutes. The mm) to yield 19.8g of purified product (99.5% by HPLC). clear solution was cooled to 22°C. for 2 hours. During this time, crystals started to appear. The mixture is stirred at Example E room temperature for 16 hours. The white crystalline prod- 0882)

TABLE 6 Summary of Examples El-3 Crude Organic Methanol HPLC Rebaudioside Ethanol Co-solvent Water Slurry Purity A (g) (95%) (mL) (mL) (mL) (mL) Yield (g) (%) E1 50 160 Methanol 25 2OO 12.7 >97 (60) E2 50 160 Methanol 25 3OO 18.6 >97 (60) E3 50 160 Methanol 25 350 22.2 >97 (60) US 2007/01 16831 A1 May 24, 2007

Example E1 ments. Accordingly, the scope of the present invention should be assessed as that of the appended claims and any 0883. A mixture of crude rebaudioside A (41% purity, 50 equivalents thereof. g), ethanol (95%, 160 mL), methanol (99.8%, 60 mL) and water (25 mL) were combined by stirring at 22°C. A white We claim: product crystallized out in 5-20 hours. The mixture was 1. A dental composition comprising: stirred for additional 48 hours. The white crystalline product was filtered and washed twice with ethanol (95%, 25 mL). an active dental Substance; The wet cake of white crystalline product then was slurried at least one high-potency Sweetener; and in methanol (99.8%, 200 mL) for 16 hours, filtered, washed twice with methanol (99.8%, 25 mL), and dried in a vacuum at least one Sweet taste improving composition. oven at 60° C. for 16-24 hours under reduced pressure (20 2. The dental composition of claim 1, wherein the at least mm) to give 12.7 g of purified product (>97% by HPLC). one high-potency Sweetener comprises a natural high-po tency Sweetener selected from the group consisting of rebau Example E2 dioside A, rebaudioside B, rebaudioside C, rebaudioside D, rebaudioside E, rebaudioside F, dulcoside A, dulcoside B, 0884. A mixture of crude rebaudioside A (48% purity, 50 rubusoside, Stevia, Stevioside, mogroside IV. mogroside V. g), ethanol (95%, 160 mL), methanol (99.8%, 60 mL) and Luo Han Guo Sweetener, Siamenoside, monatin and its salts water (25 mL) was combined by stirring at 22°C. The white (monatin SS, RR, RS, SR), curculin, glycyrrhizic acid and product crystallized out in 3-6 hours. The mixture was its salts, thaumatin, monellin, mabinlin, braZZein, heman stirred for additional 48 hours. The white crystalline product dulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, was filtered and washed twice with ethanol (95%, 25 mL). baiyanoside, osladin, polypodoside A, pterocaryoside A, The wet cake of white crystalline product then was slurried pterocaryoside B, mukurozioside, phlomisoside I, perian in methanol (99.8%, 300 mL) for 16 hours, filtered, washed drin I, abrusoside A, cyclocarioside I, and combinations twice with methanol (99.8%, 25 mL) and dried in a vacuum thereof. oven at 60° C. for 16-24 hours under reduced pressure (20 3. The dental composition of claim 1, wherein the at least mm) to give 18.6 g of purified product (>97% by HPLC). one high-potency Sweetener comprises a synthetic high potency Sweetener selected from the group consisting of Example E3 Sucralose, acesulfame potassium and other salts, aspartame, alitame, saccharin, neohesperidin dihydrochalcone, cycla 0885. A mixture of crude rebaudioside A (55% purity, 50 mate, neotame, N-N-3-(3-hydroxy-4-methoxyphenyl)pro g), ethanol (95%, 160 mL), methanol (99.8%, 60 mL) and pyl-L-C.-aspartyl-L-phenylalanine 1-methyl ester, N-N- water (25 mL) was combined by stirring at 22°C. The white 3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl-L-C.- product crystallized out in 15-30 minutes. The mixture was aspartyl-L-phenylalanine 1-methyl ester, N-N-3-(3- stirred for an additional 48 hours. The white crystalline methoxy-4-hydroxyphenyl)propyl-L-C.-aspartyl-L- product was filtered and washed twice with ethanol (95%, 25 phenylalanine 1-methyl ester, salts thereof, and mL). The wet cake of white crystalline product was slurried combinations thereof. in methanol (99.8%, 350 mL) for 16 hours, filtered, washed 4. The dental composition of claim 1, wherein the at least twice with methanol (99.8%, 25 mL) and dried in a vacuum one Sweet taste improving composition comprises a first oven at 60° C. for 16-24 hours under reduced pressure (20 Sweet taste improving composition selected from the group mm) to give 22.2 g of purified product (>97% by HPLC). consisting of carbohydrates, polyols, amino acids and their corresponding salts, polyamino acids and their correspond Example F ing salts, Sugar acids and their corresponding salts, organic acids, inorganic acids, organic salts, inorganic salts, bitter 0886. A solution of rebaudioside A (>97% pure by HPLC compounds, flavorants, astringent compounds, polymers, ) was prepared in double distilled water (12.5gm in 50 mL. proteins or protein hydrolysates, Surfactants, emulsifiers, 25% concentration) by stirring the mixture at 40° C. for 5 flavonoids, alcohols, and combinations thereof. minutes. An amorphous form of rebaudioside A was formed 5. The dental composition of claim 1, wherein the at least by immediately using the clear Solution for spray drying one Sweet taste improving composition imparts a more with the Lab-Plant spray drier SD-04 instrument (Lab-Plant Sugar-like temporal profile to the dental composition than Ltd., West Yorkshire, U.K.). The solution was fed through the sweetener would have without the at least one Sweet taste the feed pump into the nozzle atomizer which atomized it improving composition. into a spray of droplets with the help of a constant flow of 6. The dental composition of claim 1, further comprising nitrogen/air. Moisture was evaporated from the droplets at least one second Sweet taste improving composition under controlled temperature conditions (about 90 to about different from the at least one first sweet taste improving 97 C.) and airflow conditions in the drying chamber and composition and selected from the group consisting of resulted in the formation of dry particles. This dry powder carbohydrates, polyols, amino acids and their corresponding (11-12g, HO 6.74%) was discharged continuously from the salts, polyamino acids and their corresponding salts, Sugar drying chamber and was collected in a bottle. The solubility acids and their corresponding salts, organic acids, inorganic in water at room temperature was determined to be >35.0%. acids, organic salts, inorganic salts, bitter compounds, fla 0887 While the invention has been described in detail Vorants, astringent compounds, polymers, proteins or pro with respect to specific embodiments thereof it will be tein hydrolysates, Surfactants, emulsifiers, flavonoids, alco appreciated that those skilled in the art, upon attaining an hols, and combinations thereof. understanding of the foregoing, may readily conceive of 7. The dental composition of claim 6, further comprising alterations to, variations of, and equivalents to these embodi at least one third Sweet taste improving composition differ US 2007/01 16831 A1 May 24, 2007 42 ent from the at least one first Sweet taste improving com Sucralose, acesulfame potassium or other salts, aspartame, position and the at least one second Sweet taste improving alitame, saccharin, neohesperidin dihydrochalcone, cycla composition and selected from the group consisting of mate, neotame, N-N-3-(3-hydroxy-4-methoxyphenyl)pro carbohydrates, polyols, amino acids and their corresponding pyl-L-C.-aspartyl-L-phenylalanine 1-methyl ester, N-N- salts, polyamino acids and their corresponding salts, Sugar 3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl-L-C.- acids and their corresponding salts, organic acids, inorganic aspartyl-L-phenylalanine 1-methyl ester, N- -3-(3- acids, organic salts, inorganic salts, bitter compounds, fla methoxy-4-hydroxyphenyl)propyl-L-C.-aspartyl-L- Vorants, astringent compounds, polymers, proteins or pro phenylalanine 1-methyl ester, salts thereof, and tein hydrolysates, Surfactants, emulsifiers, flavonoids, alco combinations thereof. hols, and combinations thereof. 27. The dental composition of claim 25, wherein the at 8. The dental composition of claim 1, wherein the at least least one synthetic high-potency Sweetener comprises sac one high-potency Sweetener is rebaudioside A, Stevioside, charin or acesulfame potassium or other salts. Stevia, or combinations thereof. 28. The dental composition of claim 27, wherein the at 9. The dental composition of claim 8, wherein the at least least one synthetic Sweetener is present in the dental com one Sweet taste improving composition comprises a polyol. position in an amount from about 10 ppm to about 100 ppm 10. The dental composition of claim 9, wherein the at least of the composition. one polyol comprises erythritol. 29. The dental composition of claim 8, wherein the 11. The dental composition of claim 9, wherein the at least rebaudioside A comprises rebaudioside A in a purity greater one polyol comprises Xylitol. than about 70% rebaudioside A by weight on a dry basis. 12. The dental composition of claim 8, wherein the at least 30. The dental composition of claim 8, wherein the one Sweet taste improving composition comprises at least rebaudioside A comprises rebaudioside A in a purity greater one amino acid. than about 80% rebaudioside A by weight on a dry basis. 13. The dental composition of claim 12, wherein the at 31. The dental composition of claim 8, wherein the least one amino acid comprises glycine, alanine, proline, rebaudioside A comprises rebaudioside A in a purity greater hydroxyproline, glutamine, or combinations thereof. than about 90% rebaudioside A by weight on a dry basis. 14. The dental composition of claim 8, wherein the at least 32. The dental composition of claim 8, wherein the one Sweet taste improving composition comprises at least rebaudioside A comprises rebaudioside A in a purity greater one polyamino acid. than about 97% rebaudioside by weight on a dry basis. 15. The dental composition of claim 14, wherein the at 33. The dental composition of claim 8, wherein the least one polyamino acid comprises poly-L-aspartic acid, rebaudioside A comprises rebaudioside A in a purity greater poly-L-C.-lysine, poly-L-e-lysine, poly-L-O-Omithine, poly than about 98% rebaudioside by weight on a dry basis. e-ornithine, poly-L-arginine, salts thereof, or combinations 34. The dental composition of claim 8, wherein the thereof. rebaudioside A comprises rebaudioside A in a purity greater 16. The dental composition of claim 8, wherein the at least than about 99% rebaudioside by weight on a dry basis. one Sweet taste improving composition comprises at least 35. The dental composition of claim 1, wherein the dental one inorganic salt. composition is selected from the group consisting of mouth 17. The dental composition of claim 16, wherein the at freshening agents, gargling agents, mouth rinsing agents, least one inorganic salt comprises a sodium, potassium, toothpaste, tooth polish, dentifrices, mouth sprays, teeth calcium, or magnesium salt. whitening agent, dental floss, and combinations thereof. 18. The dental composition of claim 16, further compris 36. The dental composition of claim 1, wherein the active ing at least one inorganic phosphate. dental Substance comprises a Substance selected from the 19. The dental composition of claim 18, wherein the at group consisting of anticaries drugs, fluoride, Sodium fluo least one inorganic phosphate comprises a sodium, potas ride, Sodium monofluorophosphate, Stannos fluoride, hydro sium, calcium, or magnesium phosphate. gen peroxide, carbamide peroxide, antibacterial agents, 20. The dental composition of claim 16, further compris plaque removing agents, stain removers, anticalculus agents, ing at least one inorganic chloride. abrasives, baking Soda, percarbonates, perborates of alkali 21. The dental composition of claim 20, wherein the at and alkaline earth metals, and combinations thereof. least one inorganic chloride comprises a Sodium, potassium, 37. The dental composition of claim 1, further comprising calcium, or magnesium chloride. a bulk sweetener. 22. The dental composition of claim 8, wherein the at least 38. The dental composition of claim 1, wherein the sweet one Sweet taste improving composition comprises at least taste improving composition functions as a bulk Sweetener. one carbohydrate. 39. The dental composition of claim 1, wherein the active 23. The dental composition of claim 22, wherein the at dental Substance is present in the dental composition in an least one carbohydrate comprises sucrose, high fructose corn amount in the range of about 50 ppm to about 3000 ppm of Syrup, glucose, or Sucrose. the dental composition. 40. The dental composition of claim 1, wherein the natural 24. The dental composition of claim 23, wherein the at high-potency Sweetener is present in the dental composition least one carbohydrate is present in the dental composition in an amount in th range of about 1 ppm to about 5,000 ppm in an amount from about 10,000 ppm to about 80,000 ppm of the dental composition. of the composition. 41. The dental composition of claim 1, wherein the sweet 25. The dental composition of claim 8, wherein the at least taste improving composition is present in the dental com one Sweet taste improving composition comprises at least position in an amount in the range of about 0.1 ppm to about one synthetic high-potency Sweetener. 100,000 of the dental composition. 26. The dental composition of claim 25, wherein the at least one synthetic high-potency Sweetener comprises k k k k k