Appendix 12 COUNTRY REPORT OF TURKEY FOR FMD A. Naci Bulut, VMD 1. OUTBREAK SITUATION 1.1. FMD situation between 2005 2007 in Turkey The disease is endemic in Anatolia Region, Two serotypes; O 1 Manisa and A type have been circulating in Anatolia Region. Outbreaks due to type Asia 1 has not been reported since April 2002 in Turkey. In 2005 majority of outbreaks were occurred with type O1 Manisa until a new A type was introduced to country on November; a total of 122 FMD outbreaks have been detected, 102 due to type O and 20 due to type A (Figure.1) Type A outbreaks have not been detected in Turkey between June 2005 and November 2005. Following the determination of one outbreak due to type A in the Eastern province of Elazıg in November and occurred 13 further outbreaks in December. According to epidemiological study results, index case was detected in Igdır province, located on Turkey and Iran border, one month earlier than Elazıg outbreak. Laboratory analysis of these viruses showed that this type A viruses were genetically quite distant from both A Iran 96 and A Iran 99 virus topotypes, both of which have been circulating in Turkey recently. The sequence data which was obtained in Ankara Sap Institute was sent to WRL Pirbright Laboratory and these viruses were closely matched with viruses isolated in Iran in 2005.
18 16 14 12 10 TYPE O 8 TYPE A 6 4 2 0
MAY JULY JUNE APRIL MARCH AUGUST JANUARY
OCTOBER FEBRUARY NOVEMBER DECEMBER SEPTEMBER Fig.1. Distribution of the 2005 outbreaks in Turkey The viruses which were isolated from Iran were antigenically matched with A 22 Iraq vaccine strain. The antigenic relationship of these viruses with A Iran 96 and A Iran 99 vaccine strains were very weak. These findings of Pirbright Laboratory were confirmed in Sap Institute as well and A 22 Mahmatlı vaccine strain was determined as the best vaccine strain against these new viruses. After the introducing of type A05 Iran strain to Turkey, the disease was spread all the regions and showed its effects enormously on livestock. Since vaccine unavailability and animal movements occurred during the Kurban Festival, numbers of outbreaks were reached on pick on February 2006. Fortunately, new vaccine was delivered and implemented starting on February which was resulted the disease was taken slightly under control. However given seasonal effects, melting snow and animal movements to grazing area, the second big pick was observed during the spring time. Since the outbreaks were taken under control by effective control measures including increased field immunity level, numbers of outbreaks were decreased starting to summer and finally end of the year a few outbreak was recorded with type A 05 Iran.
85 However, a new type O strain, O pan Asia, was introduced to Turkey on October while number of type A outbreaks were seen declining (more detailed information below on 1.2. subtitle) The disease has not been seen in Thrace Region between on June 2001 February 2006. Beginning of February, the disease occurred in this region. The isolated viruses from Thrace region were also sequenced and found to be same as new viruses isolated from Anatolia recently. Consequently, total of 16 type A05 Iran outbreaks were occurred in Thrace region in 2006. Last FMD outbreak in 2006 was occurred in Silivri district of Istanbul province, Thrace Region on 03.07.2006. In 2006, a total of 827 FMD outbreaks have been reported, 48 due to type O; 769 due to type A (fig.2).
DISRIBUTION OF 2006 OUTBREAKS
200 161 150 140 TYPE A (769) 100 110 TYPE O (48) 71 79 50 50 54 27 33 NUMBER OF OUTBREAK NUMBER 20 14 24 0 7 5 3 1 2 1 2 3 10 July April May June March August January October February November December September MONTHS
Figure.2. Distribution of FMD outbreaks in 2006
1.2. CURRENT FMD OUTBREAK SITUATION Turkey has been under the high risk with circulating a severe virulent new O subtype, O Pan Asia strain because of occurrence uncontrolled animal movements from outside and within the country. Epidemiological investigation and molecular epidemiologic studies were indicated that O Pan Asia substrain has been introduced to Turkey up to October 2006, beside existed domestic strains O Manisa/ O Alfa 05 topotype, which were caused a few outbreaks before the October 2006. It has been recently recorded outbreaks mostly with type O, a total of 366 outbreaks were detected, 203 of by type O, 23 of by type and 140 of untyped respectively in 2007 (up to Macrh) (Table.1and fig.3). OUTBREAKS Month Type O A UNTYPED TOTAL SUSCEPTIBLE CASES DEATH October 06 2 20 November 06 3 14 December 06 24 10 January 07 122 17 37 176 156989 4563 1383 February 07 63 6 44 113 80945 2036 453 March 07 18 0 59 77 66056 2169 752 Total 232 67 140 439 303990 8768 2502 Table 1. Distribution of recent FMD outbreaks
86 CURRENT FMD OUTBREAK SITUATION (OCTOBER 2006-MARCH 2007
140
120 122 100 80 60 63 59 44 40 37
OUTBREAKS NUMBER OF 24 20 20 14 17 18 10 6 0 2 3 0 March January October February November December MONTH O A UNTYPED Fig.3. Recent outbreaks situation Although it was recorded 48 outbreaks with type O in 2006 and those isolates were dropped in O Alfa 05 lineage genetically, the numbers of type O outbreaks were increased at beginning of October 2006. Because of the effects of animals movements during the Kurban Festival (end of the year), viruses were spread all over the country and numbers of outbreaks were reached on pick on January 2007. According to genetic analysis of isolates, a new type O pan Asia sub strain was detected first time at Selvioglu village in U ak on 8 th October 2006. The sequence data which was obtained in Ankara Sap Institute showed that this virus was closely matched with viruses isolated in Iran in 2006. It is uncertain that whether this was index case or not for the new sub strain Since U ak province is located west of Turkey, in Aegean Region, it was probable that it might be occurred another case in East Region of Anatolia, close to Iran border. . It is probable that the disease with type O Panasia sub strain was occurred in another place where is near to border after the entrance into the country. However it is clear that this was available first evidence indicated genetic changing of circulating viruses. Many further sequence data which was made in Ankara Sap Institute on between October 2006 and March 2007 also supported that O pan Asia strain was circulated all over the country. Those studies were indicated that the isolates were not only closed to Iran isolates but also they were closed to isolates of Middle East Region, particularly of Jordan. The recent data made on March showed that isolates collected from ırnak Province in South East Region of Turkey, near to Iraq/Syria border were closed to these lineages. (Table.2 and Dendograms as annex). PROT.NO PROVINCE YEAR MONTH TYPE GENOTYPE TOPOTYPE 6 Edirne 2007 January A A05 ASIA 5 Erzincan 2007 January O PANASIA ME SA 13 Muğla 2007 January O PANASIA ME SA 15 Tokat 2007 January A A05 ASIA 83 Konya 2007 January O PANASIA ME SA 120 Konya 2007 January O PANASIA ME SA 207 Kastamonu 2007 January A A05 ASIA 285 ırnak 2007 February O PANASIA ME SA 324 Bolu 2007 February A A05 ASIA 357 Kırklareli 2007 February O PANASIA ME SA 370 Isparta 2007 February A A05 ASIA Table.2. Results of nucleotide sequence analysis
87 In addition to those situations, some other sequence results indicated that O Alfa 05 sub strain has been also still circulated in Anatolia which was similar to isolates caused outbreaks in 2005. Although it was detected genetically differences of O virus as Panasia and affected severe clinically on animals, recent available antigenic studies, R Value ELISA, show that there has been no changing antigenically, which O1 Manisa vaccine strain has been covered both sub strains. The data for type A 05 Iran outbreaks which detected as limited number in 2007 show that it has been closed to their genetic lineages and given high protection well antigenically ( table 2 and Dendogram.2.) As a conclusion, it has been already type O Pan Asia sub strain was introduced to Turkey from two different origins and caused many outbreaks all over the country which is genetically quite distant from old isolates and no differences antigenically, which is protected with O Manisa vaccine strain. 1.3. 2007 Outbreaks in Thrace In 2007, three outbreaks has been detected in Trace Region, because of uncontrolled animal movements after the Kurban Festival. The detail for those are as follow:
a. Oğulpa a, Havsa Edirne Outbreak was occurred with type A05 Iran in two premises in 3 rd January. Disease was caused by returning unsold cattle from Istanbul Bayrampa a impermanent market. As a total 11 animals were affected by disease in two holdings and they were slaughtered after laboratory confirmation. Disease was limited within the holdings, no spread to around, by taken efficient measures including ring vaccination within and around the villages b. Armağan, Kırklareli Disease was noticed by owner in 22th February in one dairy cattle, but it was reported to state veterinary centre with delaying four day. In a result of clinical diagnosis, 9 animals were detected as FMD. This result was also confirmed by Laboratory as type O After the confirmation, all animals were slaughtered. Although it was carried out outbreak investigation, the origin of transmission was unclear. It was carried out epidemiological investigation and taken efficient measures including ring vaccination. The NSP survey in village was indicated that there was no spread the disease around the diseased farm. c. Evre e, Gelibolu, Çanakkale Disease was occurred in same farm where outbreak detected previously on June 2006 and also the cause was similar with it. Officially unregistered (in that place) farmer transferred animals from Sakarya province in Anatolia to his farm in Evre e. Unless movement certificate to Evre e, (for another place in Anatolia), he transferred the animals his land in Evre e. Since the animals were contacted with the virus before (according to investigation
88 evidence), they were catch the disease by arriving Evre e village on 30 th March. At the beginning the outbreak, 8 animals were affected in this farm, but later on virus was spread to another two neighboring farms; as a total 15 animals were affected at three farms. According to epidemiological assessment (Since location of those 3 farms was apart from main village area), in addition those affected cattle, 61 animals (35 cattle and 26 buffalo; in total 76) were slaughtered and ring vaccination was implemented in the village 1.4. Evaluation of the FMD Outbreaks in Turkey When it is overviewed disease events of last seven years, it is clear that Turkey has been experienced with FMD outbreaks different epidemiological features year to year in him disease history. In a year it has been occurrence an upsurge of outbreaks caused by one new type, which was invaded all over the country and those were taken the under control by efficient measures; in the next year it has been welcomed again a new upsurge of outbreaks caused another FMD type, such as Asia 1 outbreaks in between 1999 and 2001, A 05Iran in 2005/2006 and now current type O Panasia. It is clearly appeared that FMD outbreaks were very frequent in villages and probably in fattening herds, in population which can contact with movement animals and given the age of young primo vaccinated or unvaccinated animals , but occurred only occasionally in specialised cattle dairy herds. This observation suggests that the former herds constitute a reservoir of FMDV and that they might be a source of outbreaks for dairy herds, which have better biosecurity measures. However, it is difficult to explain this pattern of outbreaks by taking in account that all types of epidemiological units are intensely and equally vaccinated against FMD, in absence of serosurveillance data to estimate the herd immunity level. The data of vaccination coverage for Autumn 2006 clearly show that some area, in which particularly has high risk for FMD, like East and South east Region, has very poor coverage which is also allow the maintains of circulating live virus. And also it was observed that variability of vaccination coverage in unit (village) can be resulted same risk. Some owners refuse to have their cattle vaccinated, because they are scared/suppose that the vaccination might induce abortion, decrease of milk production, and for others the vaccinators bring FMD on their farm and also for others have no highly awareness of the disease etc. In addition, animals that are not 3 months of age at the moment of the vaccine phase might remain unvaccinated until the following phase and thus until the age of around 7 months. In these conditions, the existence of non or not properly vaccinated animals reveals the presence of FMDV in the environment brought by other animals, humans, vehicles, etc. In all this circumstances, animal movements should be taken strongly consideration on risk to help by the spread the existed circulating virus. During the outbreaks, although it was conducted control measures to stop the spread of the disease and achieved it partly resulted by decreasing number of outbreaks, it should be considered that it can not be fully eradicated the disease in the country and around the country. This consideration has been raised the questions on our epidemiological situation and tools that it has been used for combating the disease. In this respect, it is clear that the strategy already used for combating the disease should be revised and defined an effective policy. To achieve this objective, some points which can be considered are as follow: Conduct a well structured network within country and particularly as regional to maintains sharing information, informing emerging events ect Recent disease experiences clearly learnt that risk on entrance of disease from outside the country is very high. For this reason, Can be constituted coordination with neighboring country by leadership an International Organization (ex: EUFMD/OIE) to stop: º Animals movement º the spread of the disease by the others way Recent experiences have been learnt that animal movement is the main element the spread of the disease. For this reason, it should be revised current policy on it and find a well structured measure for it. For instance: ºdialer should be taken under the registration system and it should be trained them. For this it needs a new legislation º It shoul be find practical solution for movements during the Kurban Festival and relating to this returning unsold animals and design of Kurban market
89 Encourage owner for early notification of disease Improvement epidemiological investigation to detect the disease earlier and to stop further the spread of the disease. For this purpose, it can be constitute a epidemiological team only responsible for disease investigation; for example at FMD Institute Remind and to train animal owners and their staffs in biosecurity control measures concerning: importance of the disease, movements: animals, vehicles, humans and Disinfection This recent situation demonstrates once again that the vaccination is only not sufficient tool to control FMD and needs to be associated with strong sanitary measures. It should be established a regional vaccine/sub strain bank to be preparedness for entrance a new strain General Measures taken in the out break areas: In order to prevent entrance of new virus types into Turkey, a surveillance program has been introduced in the East and the South Eastern border regions. Also the restriction of animal and animal products movements, quarantine, intensive vaccination programs and active monitoring and surveillance programs have been introduced. In case of outbreaks, ring vaccination program is applied in the focus. Due to the insufficiency in the vaccine production and unwillingness of the farmers, vaccination of the sheep can not be carried out under a nationwide program. Diagnosis, research and vaccine production services are carried out by Foot and Mouth Disease Institute, located in Ankara. 2. Vaccination programme in 2006 Mass vaccination policy was the main element of the control programme against FMD. Vaccination Programme which has been implemented in 2006 is as follows; • Vaccination policy o Spring vaccination campaign using trivalent vaccine in March and April o Autumn vaccination campaign using trivalent and bivalent vaccine in September and October o Thrace and Marmara Region; Vaccination of all ruminants o In the other regions in Turkey; Vaccination of all large ruminants • Vaccination o Large Ruminant: • Application of routine mass vaccination twice a year all large ruminants in the country, • Application of strategic vaccination to large ruminants in the selected region at the Black Sea Region o Small Ruminant: • Application of routine mass vaccination once a year all ruminants in the Thrace and Marmara regions . Trivalent (2 501 500 doses) and bivalent FMD vaccine (1 660 000 doses) donated by EUFMD/EC is being used in Thrace Region and selected region in Anatolia and also FMD Institute vaccines being used in Anatolia.
90 Distribution of trivalent and bivalent FMD vaccine donated by EUFMD/EC in 2006 Trivalent Vaccine Spring Autumn Povince Vaccine dose Vaccine dose Total EDIRNE 225.000 135.000 360.000 TEKIRDAG 114.000 104.000 218.000 KIRKLARELI 104.500 90.000 194.500 ISTANBUL 75.000 60.000 135.000 CANAKKALE 237.000 99.000 336.000 BALIKESIR 462.000 240.000 702.000 BURSA 89.000 108.000 197.000 BILECIK 40.000 27.000 67.000 YALOVA 10.000 9.000 19.000 KOCAELI 55.000 45.000 100.000 SAKARYA 80.000 63.000 143.000 DÜZCE 0 30.000 33.000 Total 1.491.500 1.010.000 2.501.500 Bivalent Vaccine for Autumn Province Vaccine dose ANKARA 99.000 KONYA 198.000 KARAMAN 15.000 KIRIKKALE 15.000 YOZGAT 99.000 KIRSEHIR 30.000 AKSARAY 30.000 NEVSEHIR 25.000 KAYSERI 99.000 SIVAS 171.000 CORUM 81.000 AMASYA 81.000 TOKAT 171.000 ESKISEHIR 81.000 DENIZLI 72.000 BURDUR 72.000 USAK 60.000 AFYON 171.000 KUTAHYA 90.000 Total 1.660.000
91 New trivalent FMD vaccine donated by EUFMD/EC on November 2006 As a total 1000.000 doses trivalent FMD vaccine have been delivered to Sap Institute on November 2006 Those vaccines were used for emergency vaccination during the Kurban Festival and 2007 Spring Vaccination Campaign for Thrace.
2.1. Spring vaccination campaign in 2006 Spring vaccination campaign was carried out between March and April 2006. Trivalent vaccine donated by EUFMD/EC was used in Thrace Region. Trivalent vaccine produced by FMD Institute was used in Anatolia Region. In the framework of the vaccination campaign 92 % of large ruminants and 82 % of small ruminants in Thrace Region and 72 % of programmed large ruminants and 98 % of small ruminants in Anatolia Region were vaccinated respectively. Spring vaccination figures are given in Table 3 and 4 as follows: Table.3. Vaccination figures for Spring 2006 campaign in Turkey Large Ruminants Small Ruminants Region Programme Vaccinated. % Programme Vaccinated. % Anatolia 9.611.857 6.943.394 72 1.757.934 1.721.279 98 Thrace 527.153 484.630 92 900.180 737.123 82 Total 10.139.010 7.428.024 73 2.658.114 2.458.402 92 Table.4. Vaccination figures for Spring 2006 campaign in Thrace Province Vaccination programme Vaccination of animals Large rum. Small rum. Large rum. % Small rum. % CANAKKALE 115257 29979 90383 78 214461 64 EDIRNE 142236 14071 134357 94 178093 76 ISTANBUL 61460 4151 62826 102 53257 96 KIRKLARELI 86004 20262 87184 101 167288 120 TEKIRDAG 122196 5922 109880 90 124024 94 Total 527153 74385 484630 92 737123 82 2.2 Autumn vaccination campaign in 2006 Autumn vaccination campaign was carried out between September and October 2006. Trivalent and bivalent vaccines donated by EUFMD/EC were used in Thrace Region and selected Anatolia region. Trivalent vaccine produced by FMD Institute was used in Anatolia Region.
Although 88 % of large ruminants were vaccinated in Thrace Region, 72 % of programmed large ruminants were vaccinated nationwide. Autumn vaccination figures are given in Table 5 and 6 as follows;fig.1 and table 1: Table 5. Vaccination figures for Autumn 2006 campaign in Turkey Programme Vaccinated. % Anatolia 9.140.818 6.526.858 71 Thrace 527.097 462.685 88 Total 9.667.915 7.009.030 72
92 Table 6. Vaccination figures for Autumn 2006 campaign in Thrace Province Vaccination programme of animals Large rum. Small rum. Large rum. % CANAKKALE 115.261 81.700 71 EDIRNE 142.236 128.238 90 ISTANBUL 61.460 59.934 98 KIRKLARELI 86.004 78.407 91 TEKIRDAG 122.136 114.406 94 Total 527.097 462.685 88
93 3. VACCINE PRODUCTION AND AVAILABILITY AT AP INSTITUTE FOR SPRING VACCINATION CAMPAIGN During the six months period for renovation some part of vaccine department, Antigen Concentration, Inactivation, Vaccine Formulation and Vaccine Bottling Units at ap Institute were reconstructed according to GMP rules and has been ready for production and finally vaccine production was started on January 2007. 5 million doses trivalent vaccines have been already produced and delivered to use and some amount of antigen, which is equal to 4 million trivalent vaccines, is waited to be bottling which means that preparation of vaccine to be need for spring vaccination campaign has been already achieved successfully. According to the vaccination program, vaccine production will be continued to be used for the next campaign. Vaccine strains produced at ap Institute are as follow: O1 Manisa Matches with new variants of Pan Asia type O A22 Iraq 24/67 Matches with a Iran 05 Asia 1 Shammir Spring vaccination campaign has been started on beginning of March and will be completed in end of April. Since the campaign has not been finalised, data for coverage of vaccination will be presented after the campaign.
94 Annex.1. FMDV Type A phylogram for regional strains circulating in 1998 to present A10Holl/NET/1942 A/EGY/1/2006 A/EGY/2/2006 A15/T/1960|AY593755.1|VP1 A/Ind/170/88 A/India/253/98 A/Ind/236/99 A/India/302/88 A/Ind/160/90 A/India/61/88 A/IRN/22/99 A/Igdir/TUR/382/06/99 A/Kayseri/TUR/1263/11/00 A/Erzurum/TUR/222/06/03 A/Elazig/TUR/453/11/03 A/Afyon/TUR/214/06/03 A/Sakarya/TUR/75/03/04 A99/Konya/TUR/311/05 A/Kirsehir/TUR/124/05/04 A99/Konya/TUR/160/04 A/Afyon/TUR/245/06/03 A/TUR/5/2003 A99/Kayseri/TUR/238/04 A/Afyon/TUR/246/06/03 A/Afyon/TUR/244/06/03 A99/Kayseri/TUR/237/04 A/IRN/2/87 A/India/395/88 A22/Ind/17/77 A22/Iraq/1964 A22/Mahmatli/1965 A22/USSR/65 A22-550 A/IND/256/98 A/GUA/24/91 A/TUR/2/2003 A/TUR/Hmn A/TUR/4/2003 A/IRN/17/2005 A/IRQ/108/2002 A/IRN/5/2003 A/IRN/33/2004 A/Burdur/TUR/205/06/04 A/IRN/98 A/Aydin/TUR/148/03/98 A/Burdur/185/03/98 A/Burdur/TUR/186/03/98 A/Balikesir/TUR/28/01/98 A/Aydin/TUR/51/01/98 A/Ankara/TUR/89/02/98 A/Kutahya/TUR/45/01/98 A/IRN/32/2001 A/IRN/34/2001 A/IRN/2/2002 A/IRN/6/2002 A/IRN/7/2003 A/IRN/7/2004 A/IRN/41/2003 A/IRN/26/2003 A/PAK/5/2006 A/IRN/53/2005 A/Aydin/1451/2006 A/IRN/22/2005 A/IRN/5/2006 A/PAK/1/2006 A/PAK/3/2006 A/Hakkari/1240/2006 A/Bolu/324/2007 A/Van/1269/2006 A/Hakkari/1266/2006 A/Van/1416/2006 A/Diyarbakir/553/2005 A/IRN/4/2005 A/IRN/1/2005 A/Denizli/1068/2006 A/IRN/29/2005 A/IRN/10/2005 A/IRN/16/2005 A/IRN/13/2005 A/Eskisehir/1115/2006 A/Samsun/738/2006 A/Bursa/1250/2006 A/Aydin/1400/2006 A/Kastamonu/208/2007 A/Amasya/1433/2006 A/Afyon/1374/06 A/Usak/1401/2006 A/Ardahan/347/2006 A/Erzurum/203/2006 A/Balikesir/330/2006 A/Nevsehir/331/2006 A/Canakkale/1012/2006 A/Kars/957/2006 A/Igdir/979/2006 A/Konya/700/2006 A/Edirne/6/2007 A/Tokat/48/2007 A/Adana/1048/2006 A/Tunceli/1091/2006 A/Ankara/29/2006 A/Ankara/969/2006 A/Kayseri/1024/2006 A/Ankara/546/2005 A/Diyarbakir/1088/2006 A/Bingöl/571/2006 A/Bingol/1096/2006 A/Elazig/542/2005 A/Elazig/548/2005 A/Kastamonu/337/2006 A/Igdir/1050/2006 A/Bolu/658/2006 A/Konya/1372/2006 A/Isparta/370/2007 A/Afyon/583/2006 A/Konya/562/2005 A/Tekirdag/194/2006 A/Bolu/552/2005 A/Bolu/565/2005 A/Kirklareli/175/2006 A/Tekirdag/270/2006 A/Kirklareli/161/2006 A/Mersin/560/2005 A/Gaziantep/569/2005 A/Samsun/739/2006 A/Samsun/1025/2006 A/Kastamonu/1104/2006 A/IRN/7/2006 A/Konya/1029/2006 A/Bilecik/564/2005 A/Kutahya/570/2005 A/Diyarbakir/664/2006 A/Kars/726/2006 A/Erzincan/1084/2006 A/Kars/764/2006 A/Mus/1443/2006 0.1
95 Annex.2. FMDV Type O phylogram for regional strains circulating in 1998 to present
O1/FRG/Kaufbeuren6 O/XJ O/HKN/1/2006 6 O/HKN/6/200 O/HKN/10/200 4 O/PAK/17/200 4 O/PAK/16/2003 O1/Manisa/Turkey/63 9 O/Igdir/472/199 O/IRN/15/9 O/TUR/1/9 8 O/Sivas/61/200 6 O/TUR/5/200 1 O/TUR/2/200 O/GRE/27/92 O/PAK/1/2000 O/PAK/53/2006 3 O/IRN/15/200 3 O/PAK/15/200 O/IRN/61/2004 2 O/IRN/4/200 ran 2001 1 O/IRN/20/200 Đ 3 O/IRN/6/200 O/IRN/8/200 O/IRN/15/200 3 O/Mersin/35/200 O/Mersin/13/2003 O/Ankara/250/200 4 O/KMaras//100/2004 1 O/Erzincan/211/200 O/TUR/7/2003 O/LEB/1/2003 3 O/ISR/7/200 3 O/ISR/2/200 4 O/ISR/8/200 O/ISR/11/200 O/IRN/6/200 O/Denizli/87/200 O/Denizili/73/200 4 O/Denizli/152/2003 3O/Eskisehir/384/200 3 O/Denizli/441/200 3 O/Nigde/353/200 3 O/KMaras/1127/200 3O/Burdur/109/0 6 O/Burdur/110/200 6 O/Aydin/125/0 6 O/Mersin/385/200 O/Afyon/260/2006 O/ISR/1/200 O/alfa/ O/ISR/2/200 6 O/ISR/1/200 6 O/Snir/0 O/Ardahan/353/2005 O/Konya/395/2005 O/Sakarya/194/2005 5 O/Adiyaman/224/200 5 O/Kayseri/386/200 O/Ardahan/474/2005 O/Erzurum/213/2005 O/Erzurum/423/200 O/Mus/465/200 O/Erzurum/248/2005 O/Igdir/513/2005 O/Rize/412/2005 O/Ardahan/340/2005 O/Konya/426/2005 O/Bayburt/226/2005 O/Sivas/510/2005 5 O/Osmaniye/193/200 5 O/Elazig/282/200 5 O/Kayseri/163/200 O/Rize/435/2005 O/Nigde/460/200 O/Kars/522/200 O/Kars/250/200 O/Kars/249/2005 O/Ardahan/326/2005 O/Elazig/338/2005 5 O/Nevsehir/242/200 5 O/Nevsehir/478/200 5 O/Nevsehir/398/200 O/Nevsehir/502/2005 5 O/Kayseri/506/200 5 O/Nigde/479/200 5O/Nigde/507/200 5 O/Kirsehir/485/200 5O/Konya/438/0 O/MAY/6/200 O/NEP/4/200 3 O/BHU/41/200 3 O/NEP/5/200 O/BHU/47/2003 M 2003 O/NEP/6/2003 alesia O/BHU/15/2003 O/BHU/33/200 O/BHU/40/200 O/BHU/30/2004 4 O/BHU/28/200 PanAsia 4 O/BHU/26/200 O/PAK/14/2004 O/PAK/4/2004 6 O/Karabuk/1472/200 6 O/Erzincan/5/200 6 O/Diyarbakir/1481/200 II O/Mugla/13/2007 6 O/IRN/10/2007 O/Sirnak/285/2007 O/IRN/8/200 O/IRN/9/200 6 O/Usak/1423/200 O/Kirklareli/357/20076 O/Konya/83/2007 I O/PAK/22/200O/Konya/120/2007 O/IRN/67/200 O/PAK/19/2005 1 O/PAK/3/200 5 O/PAK/25/200 O/IRN/2/2005 5O/IRN/16/200 3 O/IRN/58/200 O/IRN/41/200 3 O/IRN/8/200 1 O/BAR/6/9 O/IRQ/30/200 4 O/IRN/1/2009 0 O/TUR/8/200 0 O/TUR/5/200 O/MOG/2000 2001 0O/IRN/16/200 UK 0 O/PAK/45/200 O/AFG/16/2001 3 O/IRN/24/9 O/IRN/9/93 O/Konya/512/199 O/1734/RUS/200 O/Tibet/CHA/99 O/JPN/2000 9 O/SAR/200 O/UKG/35/2000 0O/IRL/134/200 O/Ankara/643/1991 1 O/TUR/1/200 9 O/Kirsehir/586/200 O/TUR/2/2003 1 O/Diyarbakir/363/200 1 O/Bursa/173/200 O/Duzce/207/200 O/Bingol/330/200 O/Bingol/332/200 5 O/Diyarbakir/319/200 O/KMaras/366/200 5 O/Amasya/100/2005 3 O/Afyon/171/200 4 O/Kutahya/134/200 O/beta/05 O/Afyon/107/2004 O/SYR/3/2004 O/Ankara/377/2004 O/TUR/12/2002 2O/Erzincan/351/200 2 O/TUR/3/200 2 O/TUR/3/200 O/Ankara/406/2003 2 O/Sivas/43/200 0. 2 1
96