Appendix I Price Overview of Oral Combination Products and Their

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Appendix I Price overview of oral combination products and their active substances The prices listed below are the average lowest unit prices in the period from 25 August to 16 November 2008

Combination product and ATC Marketed combination product, pharmaceuti- Active substance 1, Active substance 2, The Reimbursement Consumption code cal form, strength and price pharmaceutical form, strength pharmaceutical form, strength Committee’s recom- Number of persons and price and price mendation for future treated in 2006 and 2007 reimbursement status: Reimbursement, Conditional reimbursement, No reimbursement bendroflumethiazide and potas- Coated tablets Tablets Prolonged-release tablets Reimbursement 2006: 317,663 sium (C03AB01) bendroflumethiazide 1.25 mg and potassium 573 bendroflumethiazide 5 mg: potassium chloride 750 mg: 2007: 318,155 mg: DKK 0.81 DKK 0.89 DKK 0.83 bendroflumethiazide 2.5 mg and potassium 573 (only marketed as 5 mg tablets) (only marketed as 750 mg tab- mg: DKK 1.38 lets) bumetanide and potassium Coated tablets Tablets Prolonged-release tablets Reimbursement 2006: 3,232 (C03CB02) bumetanide 0.5 mg and potassium 573 mg: bumetanide 1 mg: DKK 2.49 potassium chloride 750 mg: 2007: 3,102 DKK 0.95 (only marketed as 1 mg tablets) DKK 0.83 (only marketed as 750 mg tablets) hydrochlorothiazide and amiloride Tablets hydrochlorothiazide is not mar- amiloride is not marketed as a Reimbursement 2006: 28,980 (C03EA01) amiloride 2.5 mg and hydrochlorothiazide 25 mg: keted as a single substance single substance 2007: 27,629 DKK 2.32 amiloride 5 mg and hydrochlorothiazide 50 mg: DKK 1.03 furosemide and amiloride Film-coated tablets Tablets amiloride is not marketed as a Reimbursement 2006: 2,139 (C03EB01) furosemide 40 mg and amiloride 5 mg: furosemide 40 mg: DKK 0.17 single substance 2007: 2,040 DKK 3.29

metoprolol and Prolonged-release tablets Prolonged-release tablets hydrochlorothiazide is not mar- Reimbursement 2006: 2,767 hydrochlorothiazide metoprolol 100 mg and hydrochlorothiazide 12.5 metoprolol 100 mg: keted as a single substance 2007: 2,703 (C07BB02) mg: DKK 3.72 DKK 2.99 and DKK 2.30 (2 substitution groups)

atenolol and chlorothalidone Film-coated tablets Film-coated tablets chlorothalidone is not marketed Reimbursement 2006: 4,278 (C07CB03) atenolol 50 mg and chlorothalidone 12.5 mg: atenolol 50 mg: DKK 0.23 as a single substance 2007: 3,941 DKK 1.23 atenolol 100 mg: DKK 0.49 atenolol 100 mg and chlorothalidone 25 mg: DKK 2.85 metoprolol and felodipine Prolonged-release tablets Prolonged-release tablets Prolonged-release tablets Reimbursement 2006: 1,252 (C07FB02) metoprolol 50 mg and felodipine 5 mg: metoprolol 50 mg: DKK 1.53 and felodipine 5mg: DKK 0.49 2007: 1,208 DKK 6.19 DKK 1.63 (2 substitution groups)

verapamil and trandolapril Modified-release tablets Prolonged-release tablets / pro- Capsules/hard capsules Reimbursement 2006: 767 (C08DA51) verapamil 180 mg and trandolapril 2 mg: DKK longed-release capsules, hard trandolapril 2 mg: DKK 0.68 2007: 665 7.06 verapamil 180 mg: DKK 2.64 trandolapril 4 mg (2 x 2 mg): verapamil 240 mg and trandolapril 4 mg: DKK verapamil 240 mg: DKK 0.87 and DKK 1.36 9.36 DKK 2.72 (2 substitution groups) captopril and hydrochlorothiazide Tablets Tablets hydrochlorothiazide is not mar- Reimbursement 2006: 267 (C09BA01) captopril 50 mg and hydrochlorothiazide 25 mg: captopril 50 mg: DKK 0.51 keted as a single substance 2007: 255 DKK 5.76 enalapril and hydrochlorothiazide Tablets Tablets hydrochlorothiazide is not mar- Reimbursement 2006: 33,428 (C09BA02) enalapril 20 mg and hydrochlorothiazide 6 mg: enalapril 20 mg: DKK 0.39 keted as a single substance 2007: 42,139 DKK 5.93 enalapril 20 mg and hydrochlorothiazide 12.5 mg: DKK 0.34 lisinopril and hydrochlorothiazide Tablets Tablets hydrochlorothiazide is not mar- Reimbursement 2006: 6,188 (C09BA03) lisinopril 10 mg and hydrochlorothiazide 12.5 lisinopril 10 mg: DKK 0.33 keted as a single substance 2007: 6,878 mg: DKK 3.76 lisinopril 20 mg: DKK 1.35 lisinopril 20 mg and hydrochlorothiazide 12.5 mg: DKK 0.81 perindopril and indapamide Film-coated tablets Tablets Prolonged-release tablets No reimbursement 2006: 7,097 C09BA04 perindopril 5 mg and indapamid 1.25 mg: DKK perindopril 4 mg: DKK 3.92 indapamide 1.5 mg: DKK 2.20 2007: 8,095 8.65 Film-coated tablets Tablets perindopril 5 mg: DKK 5.42 indapamide 2.5 mg: DKK 1.67 (same quantity of perindopril in 4 and 5 mg, but with different indi- cations of strength) ramipril and hydrochlorothiazide Tablets Tablets hydrochlorothiazide is not mar- Reimbursement 2006: 6,909 (C09BA05) ramipril 5 mg and hydrochlorothiazide 25 mg: ramipril 5 mg: DKK 0.51 keted as a single substance 2007: 9,699 DKK 0.92 perindopril and amlodipine Tablets Tablets Tablets Marketed from October Not marketed until Octo- (C09BB) perindopril 5 mg and amlodipin 5 mg: DKK 5.42 perindopril 4 mg: DKK 3.92 amlodipin 5 mg: DKK 0.30 2008 ber 2008 perindopril 5 mg and amlodipin 10 mg: Film-coated tablets amlodipin 10 mg: DKK 0.39 DKK 5.42 perindopril 5 mg: DKK 5.42 perindopril 10 mg and amlodipin 5 mg: (same quantity of perindopril in 4 DKK 7.17 and 5 mg, but with different indi- perindopril 10 mg and amlodipin 10 mg: cations of strength) DKK 7.17 Film-coated tablets perindopril 10 mg: DKK 7.17

Film-coated tablets Film-coated tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 39,371 losartan and hydrochlorothiazide losartan 50 mg and hydrochlorothiazide losartan 50 mg: DKK 7.47 keted as a single substance bursement 2007: 42,249 (C09DA01) 12.5 mg: DKK 7.73 losartan 100 mg: DKK 10.28 losartan 100 mg and hydrochlorothiazide 12.5 mg: DKK 12.37 losartan 100 mg and hydrochlorothiazide 25 mg: DKK 8.74 eprosartan and hydrochlorothi- Film-coated tablets Film-coated tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 1,451 azide (C09DA02) eprosartan 600 mg and hydrochlorothiazide eprosartan 600 mg: DKK 6.34 keted as a single substance bursement 2007: 1,923 12.5 mg: DKK 6.55

valsartan and hydrochlorothiazide Film-coated tablets Film-coated tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 14,399 (C09DA03) valsartan 80 mg and hydrochlorothiazide valsartan 80 mg: DKK 7.69 keted as a single substance bursement 2007: 16,717 12.5 mg: DKK 7.65 valsartan 160 mg: DKK 11.11 valsartan 160 mg and hydrochlorothiazide 12.5 mg: DKK 10.26 valsartan 160 mg and hydrochlorothiazide 25 mg: DKK 10.86 irbesartan and hydrochlorothi- Film-coated tablets/tablets Film-coated tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 10,677 azide (C09DA04) irbesartan 150 mg and hydrochlorothiazide irbesartan 150 mg: DKK 7.59 keted as a single substance bursement 2007: 11,602 12.5 mg: DKK 7.59 irbesartan 300 mg: DKK 10.71 irbesartan 300 mg and hydrochlorothiazide 12.5 mg: DKK 9.83 irbesartan 300 mg and hydrochlorothiazide 25 mg: DKK 12.10 candesartan an Tablets Tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 15,502 hydrochlorothiazide (C09DA06) candesartan 8 mg and hydrochlorothiazide candesartan 8 mg: DKK 5.32 keted as a single substance bursement 2007: 17,319 12.5 mg: DKK 7.19 candesartan 16 mg: DKK 6.73 candesartan 16 mg and hydrochlorothiazide 12.5 mg: DKK 9.13 telmisartan and Tablets Tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 5,767 hydrochlorothiazide (C09DA07) telmisartan 40 mg and hydrochlorothiazide telmisartan 40 mg: DKK 7.16 keted as a single substance bursement 2007: 7,406 12.5 mg: DKK 7.45 telmisartan 80 mg: DKK 8.84 telmisartan 80 mg and hydrochlorothiazide 12.5 mg: DKK 7.46 telmisartan 80 mg and hydrochlorothiazide 25 mg: DKK 11.61 olmesartan and Film-coated tablets Film-coated tablets hydrochlorothiazide is not mar- Conditional reim- 2006: 526 hydrochlorothiazide (C09DA08) olmesartan 20 mg and hydrochlorothiazide olmesartan 20 mg: DKK 6.23 keted as a single substance bursement 2007: 1,551 12.5 mg: DKK 6.23 olmesartan 20 mg and hydrochlorothiazide 25 mg: DKK 6.23 valsartan and amlodipine Film-coated tablets Film-coated tablets Tablets Conditional reim- 2007: 3,279 (C09DB01) valsartan 80 mg and amlodipin 5 mg: DKK 7.83 valsartan 80 mg: DKK 7.69 amlodipin 5 mg: DKK 0.30 bursement (Marketed in April 2007) valsartan 160 mg and amlodipin 5 mg: valsartan 160 mg: DKK 11.11 amlodipin 10 mg: DKK 0.39 DKK 11.36 valsartan 160 mg and amlodipin 10 mg: DKK 11.49