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PRODUCT DATA DOUGLAS LABORATORIES® 08/2013 1

Uva Ursi Max-V Bearberry for urinary health

DESCRIPTION Uva-Ursi Max-V, provided by Douglas Laboratories, supplies 200 mg of standardized Uva Ursi and 100 mg of non-standardized leaf in a vegetarian capsule.

FUNCTIONS Uva Ursi ( uva-ursi), also known as bearberry, is a low-lying evergreen shrub found in , , and . It has been used traditionally as a , astringent and urinary antiseptic for several hundred years. One of the active components in it, arbutin, releases hydroquinone, which can provide support for a healthy urinary tract.†

FORMULA (#77379) Each capsule contains: Uva ursi Herbal extract ...... 200 mg (Arctostaphylos uva-ursi L.Spreng) (Standardized to provide 40 mg (20%) arbutin) Uva Ursi (leaf) non-standardized…………………………100 mg

SUGGESTED USE Adults take 1 capsule daily between meals or as directed by a healthcare professional. Not intended for long- term use. Do not take if pregnant or lactating.

SIDE EFFECTS Uva ursi may cause nausea, vomiting, gastrointestinal discomfort, and a greenish-brown discoloration of the urine. Uva ursi contains hydroquinone which inhibits melanin synthesis and might lead to retinal thinning if used long-term. Chronic use, especially in children, can cause liver impairment due to its content.

STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children.

REFERENCES Beaux D, Fleurentin J, Mortier F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother Res 1999 May;13(3):222-5 Grases F, Melero G, Costa-Bauza A, Prieto R, March JG. Urolithiasis and phytotherapy. Int Urol Nephrol 1994;26(5):507-11 Matsuda H, Nakamura S, Tanaka T, Kubo M. [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment]. [Article in Japanese] Yakugaku Zasshi 1992 Sep;112(9):673-7 Matsuo K, Kobayashi M, Takuno Y, Kuwajima H, Ito H, Yoshida T. [Anti-tyrosinase activity constituents of Arctostaphylos uva-ursi].[Article in Japanese] Yakugaku Zasshi 1997 Dec;117(12):1028-32 Ritch-Krc EM, Thomas S, Turner NJ, Towers GH. Carrier : traditional and contemporary plant use. J Ethnopharmacol 1996 Jun;52(2):85-94.

For more information on Uva Ursi Max-V visit douglaslabs.com

PRODUCT DATA DOUGLAS LABORATORIES® 08/2013 2

Uva Ursi Max-V Bearberry for urinary health

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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