MBL annual report 2002

MARINE BIOLOGICAL LABORATORY Woods Hole, Massachusetts The Marine does not in Biological Laboratory discriminate employment or in access to any of its activities or programs on the basis of race, color, sexual religion, sex, orientation, national origin, ancestry, age, marital status, or mental or veteran In pregnancy, physical disability, status. addition, the MBL is committed to the prevention and elimination of sexual harassment, as well as other forms of unlawful in harassment, the workplace. Through training programs and disseminated MBL strives to its information, educate employees, students, faculty, and visitors on these important issues.

! ON THE COVER: Alpha ganglion cell retina, Peter Koulen

The MBL Annual Report 2002 is the Marine published by Biological Laboratory. Although the greatest possible care has been taken in the of this record, the Marine preparation Biological Laboratory recognizes the possibility of omissions or inaccuracies. If are any noted, please accept our apology and advise us of any corrections to be made.

Office of Communications and Public Affa rs Marine Biological Laboratory 7 MBL Street Woods Hole, MA 02543 Phone: (508) 289-7423 Fax (508) 289-7934 www mbl.edu Rl

TABLE OF CONTENTS

R2 REPORT OF THE DIRECTORS CEO

R7 RESEARCH

R44 EDUCATION

R63 MBL/WHOI LIBRARY

R66 FINANCIAL INFORMATION

Dogfish thrombocytes, R69 GIFTS Kyeng-Gea Lee R85 GOVERNANCE & ADMINISTRATION R2

report of the director and CEO

I am to share with you pleased Developing the Laboratory's first strategic plan from the Marine highlights has been an exciting and illuminating process Biological for the Laboratory involving participation at all levels of the 2002. I've now served as year organization. I'm most grateful to everyone Director and CEO of the MBL who has contributed to the experience.

for nearly three years. I continue to be impressed with the breadth of the science Establishing the Program in Global being done here, the impact that our basic Infectious Diseases research continues to have on human health

as well as the environment, and the remark- One of the highlights of the year was establish able commitment our scientists, faculty, and ing our newest resident research program in staff have to their work and to the Marine Global Infectious Diseases. Funded by a Biological Laboratory itself. $5 million grant from the Ellison Medical Foundation, the Program links scientists who study disease-causing organisms with experts a Plan (Developing Strategic in molecular biology, phylogenetics, and environmental microbiology and creates a Much of my time in 2002 was devoted to one-of-a-kind international center for research with MBL President John directing, Dowling and training dedicated to studying pathogens and the aid of the firm & consulting McKinsey and the complex relationships they have with Company, a planning effort aimed at devel- their hosts. oping a strategic roadmap for the Laboratory over the next five to ten This years. process, We were fortunate to recruit leading parasi- and the recommendations to date, emerging tologist and molecular biologist Stephen L. are outlined in detail on our web site Hajduk to direct the Program. Steve comes to

(www.mbl.edu/inside/what/planning/ the MBL from the University of Alabama at we continue to fine- index.html). Although Birmingham where he was a Professor in the tune the the initial of the plan, phases Department of Biochemistry and Molecular are process largely complete. Genetics and Senior Scientist in the AIDS Center and the Comprehensive Cancer Center. As a result of this we are effort, already Steve brings with him a number of students, a number of initiatives. undertaking key postdocs, and technicians. In addition, we These include developing a graduate welcomed two new Assistant Scientists program with Brown University, hiring a Chief Robert Sabatini and Andrew McArthur to the Academic and Scientific Officer, establishing Program in early 2003. a new resident research program in Cellular and the Board Dynamics Imaging, expanding Steve's research program is broadly based in of Trustees, preparing for major renovations the area of molecular and biochemical basis of of the Whitman for summer and Building pathogenesis. Many of his studies focus on and with a site visiting research, working African trypanosomes, which cause human to us further and planner help reconfigure sleeping sickness, a fatal disease that has renovate to meet the needs space emerging reemerged as a major health problem in of the strategic plan. sub-Saharan Africa. R3

The importance of research in infectious disease The MBL has a rich history in studying the basic cannot be overstated. No single reason can science of parasitism and infectious disease.

explain our inability to eradicate or minimize Twenty years ago, the laboratory launched the the global impact of infectious agents on field of molecular parasitology with the estab- human health. In total, 25% of all deaths lishment of its Biology of Parasitism course,

worldwide are caused by bacterial, viral, fungal, which continuously reinvents itself as it trains

and parasitic pathogens. Every year, one to new investigators in this ever-expanding field. three million people die from malaria, a disease The Global Infectious Diseases Program caused by the organism Plasmodium. Tubercu- includes a strong training component that will

losis infects one person every second, and over allow tropical health and infectious disease the coming decade, at least 30 million will die scientists from the world to conduct research from the disease. they would be unable to do at their home Heliozoan, Linda Amaral institutions. The lie Program's unique strengths Zettler and Erik Zettler The Global Infectious Disease Program is part within its capability to integrate visiting of the MBL's Josephine Bay Paul Center for scientists into the lab and give them access to Comparative Molecular Biology and Evolution. instruments and technology that would Directed by Mitchell Sogin, the Bay Paul Center otherwise be unavailable to them. The broad has an active research program with strong ties impact that the training component will have on to infectious disease. Bay Paul Center scientists the field of infectious diseases globally is very have contributed many important insights exciting.

about the evolution of parasitic protists using modern genomic approaches. Recently they embarked the of the Other Resident Research upon sequence analysis | Highlights G/ard/a genome. Excluding bacterial patho- The MBL's resident research in gens, Giardia is a principal cause of diarrheal program grew disease in children and adults and therapeutic other areas during 2002 as well. We welcomed Frederick in he the treatments for the parasite are almost as Goetz January, when joined devastating as the disease itself. The availabil- staff of the Marine Resources Center (MRC) as Director of the in Scientific ity of the Giardia genome may lead to the Program Aquacul- identification of novel treatments that have ture. Through exploring factors such as an

minimal side effects. organism's nutritional and water quality requirements, physiological characteristics, The technology necessary to sequence entire reproductive biology, diseases, and genetic the MBL's Scientific genomes is found at very few institutions. background, Aquaculture The MBL's Global Infectious Diseases Program Program is developing novel research tech- Clam egg, Robert Palazzo and faced both will build on the unique expertise of the Bay niques addressing problems by scientific commercial interests. Paul Center to provide more traditional and aquaculture

Rick is the efforts to parasitologists the opportunity to expand their spearheading Program's as a tool to understand research and better apply genomics to their use DNA technology research areas. This blending of genomics the growth, reproduction, and disease resis- in fish and and parasitology will create a uniquely produc- tance commercially important

shellfish. is on tive research environment and provide the He also focusing enhancing the MRC's culture and of biomedical catalyst for exciting new discoveries on the husbandry such as important pathogens. models squid, clams, toadfish, and zebrafish.

Continued... R4

Woods Ho/e aerial, Doug Weisman Pigment cells on the surface of the cunner spinal cord, Steven Zottoli

The MBL's summer and research Gabriele Gerlach also joined the staff of the MRC visiting program was further strengthened in 2002 with in 2002 as an Associate Scientist. A specialist in a remarkable and farsighted gift of $2.3 million behavioral ecology and population genetics, from long-time summer investigators Laura and Gabby is using the zebrafish facilities at the MRC Arthur Colwin. Their established the Laura to explore the genetic basis of behavior. gift and Arthur Colwin Endowed Summer Research

Fund, which, when mature, will Scientists at The Ecosystems Center received Fellowship full for 10 strong support from the National Science provide support approximately investigators conducting research Foundation through the competitive peer-review independent in the fields of cell and developmental biology grant process again this year. Of special note is at the MBL for a minimum of two months during the $2.7 million, multi-year award in support of the summer. The MBL is committed to ensuring the Long-Term Ecological Research project at that the best scientists have the Plum Island Sound, a research site located north very opportu- to conduct research here each summer. We of Boston. Here scientists are studying the nity can do this financial effects of land-use change on watersheds. The help by providing support in the form of like these. Center also received $850,000 from the Andrew fellowships W. Mellon Foundation to support research on On the recommendation of the Science nitrogen transformation in terrestrial landscapes. Council, the Laboratory reinstated the MBL Awards for outstanding presentations at the annual General Scientific in 2002. [Summer and Visiting Research Meetings During the meeting, which was held in the Lillie Auditorium 12 to 14, 56 During a typical Woods Hole summer, MBL August presentations were made. After of all and researchers look for basic principles of life in peer-review papers four awards and two honorable mentions organisms from squid to surf clams to zebrafish. talks, were in the of Senior They ask how nerve cells communicate, how cells presented categories (Peter Junior regulate their complex processes, and how they Investigator Armstrong), Investiga- tor (Michael Smotherman), Graduate Student proliferate. They explore how organisms repro- (Beate Mittman), and Student duce and develop, how they fight disease, how Undergraduate La sense organs gather information, and how brains (Jane Du).

cess it. The investigators who gather each

iner bring a diversity of approaches and questions to their research. In 2002 we wel-

comed 129 principal investigators and 237 other researchers from 124 institutions representing 12 countries. R5

Education I MBL/WHOI | Library

The 2002 Education Program provided 499 The MBL/WHOI Library continues to grow in non- informa- graduate and advanced-level students from traditional directions. More and more 288 institutions and 31 countries an opportu- tion is being delivered directly to scientists' In the nity to study a range of biological topics with desktops via the Internet. early 2002, some of the leading scientists in the world Library was delivering approximately 52% of its serving as course faculty and lecturers. The serials and 100% of its databases electronically, its walls to Laboratory welcomed 554 faculty members extending the Library's reach beyond and staff and 203 lecturers to the courses in wherever its patrons may be at any time of the 2002. They represented 175 institutions and day or night. 33 countries.

In addition, the Library is actively involved in the The MBL offered two new courses in 2002. development of new electronic research tools. "Advances in Genome Technology and Thanks to a grant of $500,000 from the Andrew Bioinformatics," was co-directed by Mitchell W. Mellon Foundation, Library and IT staff are Indexer and Sogin, director of the MBL's Bay Paul Center, developing the Universal Biological and Claire M. Fraser of The Institute of Organizer (uBio), an exciting new database and Genomic Research. Twenty-four students from Internet tool that provides an innovative means the U.S. and Europe participated in of accessing, sorting, and collating taxonomic distributed the inaugural course, held October 6 to information contained in databases

November 1, 2002. The course integrates throughout the Internet. bioinformatics with the latest laboratory collection was techniques for genome sequencing, genome A portion of the Library's archival the of 2002 in the analysis, and high-throughput gene also featured during summer as Art" exhibit in the Room. expression. "Wall Charts Meigs The exhibit showcased 1 5 life-size reproductions The second course, "Neuroinformatics," of the 1 16 charts produced by Rudolf Leukart was directed by Partha Mitra of Lucent between 1 877 and 1 892. Noted for their detail, Technologies and Emery Brown of Massachu- these charts were used as teaching aids in the world. The Archives has setts General Hospital. Twenty-six students universities around of few collections participated in that course, which was held one the remaining complete August 17 to September 1. of the original chromolithographs. We are grateful to Ann Weissmann for curating this In addition to our programs for graduate outstanding exhibit. students, the MBL also offers a "Semester in Environmental Science" program for under- each fall. In 2002, 19 undergradu- Outreach graduates | ates from 14 colleges and small universities the fall of 2002, the MBL worked with around the country participated in the pro- During Avari Studios to and the gram, which is hosted by The Ecosystems reorganize redesign MBL's web site. The new site was launched in Center. The goal of the SES program, now th 2003 to reviews. data in its 6 year, is to help prepare the next January very positive Early show that the site is visited generation of leaders in environmental being by nearly users a month. We are science and policymaking. 50,000 unique continuing to build and enhance the site, which is becoming

an increasingly important tool for institutional advancement, marketing, communications, and

outreach. If you haven't seen the new site, I

Continued. . invite you to visit it at . R6

[Construction and Facilities

We were fortunate in 2002 to be able to Thomas S. Crane were elected to serve as Continue to fund depreciation and upgrade President of the Corporation, Treasurer, our facilities. Lab and office in and space both the Clerk, respectively. Sheldon Segal was Marine Resources Center and the Crane Wing also elected to serve a final year as Chair of of Lillie the building were substantially the Board. renovated for new Marine Resources and Global Infectious Disease program staff. The On November 8, 2002, Shelly stepped down as Grass Fellows also Chair of enjoyed 1400 square feet the Board and handed his virtual gavel of newly renovated laboratory space in the to Al Zeien, the former Chairman and CEO of Whitman Building during the summer of the Gillette Company, who assumed the duties 2002. This fully modernized space was of Chair at the February 2003 meeting of the designed to meet the Fellows' research needs Board. Shelly has served as a member of the also and foster the cooperative and collegial Board for 20 years, 10 as its Chair. He will now nature of the program. Educational programs serve as an Honorary Trustee. displaced by this renovation, including SPINES and a program for undergraduates Shelly has been, and will continue to be, a vital from Williams College, were moved to the force at the MBL. On behalf of the MBL

Loeb teaching building. community, I thank Shelly for all his efforts over

these many years. I know we can count on his The MBL also purchased a five-acre farm in guidance and wisdom in the future. Newbury, MA. The property will enable the expansion of the MBL's Plum Island Research which focuses on Conclusion Program, understanding [ Eel Pond through the how coastal ecosystems are affected by front doors of Ebert Hall changing land cover, climate, and sea level. We are living in challenging times, and the Upon the departure of Ecosystems Center Marine Biological Laboratory is not immune to the staff to the C.V. Starr Building, the Homestead impact that the downturn in the national Building was gutted and renovated for use by economy is having on businesses, foundations, and state the administrative departments of Financial and local governments. Like every- Services, Human Resources, Education, and one, we've had to tighten our belts and The Biological Bulletin. The Candle House, carefully consider the impact new initiatives have on our now home to the Director's Office, Develop- may budget. So far, the MBL has ment Office, Associates Office, and Commu- been able to weather the economic storm and

nications and Public Affairs Office, also continue to work in positive ways towards received a modest facelift in 2002. achieving the goals we've begun to establish through the strategic planning process.

[Trustees This is an exciting time for the Marine Biological

Laboratory. I look forward to working with you The Board of Trustees elected five new as we further build upon the strengths of this members whose terms began in 2002. vital institution to ensure that the Marine Margaret C. Bowles of Woods Hole, MA; Biological Laboratory continues to have a Martha W. Cox of Hobe Sound, FL; Walter E. disproportionate impact on the biological, Massey of Atlanta, GA; Marcia C. Morris of biomedical, and environmental sciences long Boston, MA; and Gerald Weissmann, M.D., of into the future.

New York, NY, are all serving four-year terms as members of the Class of 2006. In addition, William T. Speck John E. Dowling, Mary B. Conrad, and R7

research

Throughout its history, the MBL has been a place where the world's top biologists can focus on their research, not distracted by departmental affairs, committee work, or other aspects of university life. The MBL provides both the resource support and the intellectual environment that enables many scientists to do their best work.

Today 47 principal investigators and and their staff conduct research at the Laboratory year- round in areas such as cellular, developmental, and reproductive biology; molecular biology and evolution; neurobiology and sensory physiology; ecology and ecosystems studies; global infectious diseases; and marine biotechnology and aquaculture. Zebrafish cardiovascular system, Jonathan The population of investigators grows dramatically each summer when hundreds of distin- Muyskens guished scientists from around the world gather here to do research. During a typical MBL summer, researchers look for basic principles of life in organisms from squid to surf clams to zebrafish. They ask how nerve cells communicate, how cells regulate their complex processes,

and how they proliferate. They explore how organisms reproduce and develop, how they fight

disease, how sense organs gather information, and how brains process it. The investigators who gather each summer bring a diversity of approaches and questions. Along with the large number of faculty associated with the summer courses, they make the MBL the largest and most exciting biological laboratory in the world.

Top photo, Elizabeth Armstrong R8

Resident Research

THE ECOSYSTT 5 CENTER

The Ecosystems Center, founded in 1975, is a collegia! association of scientists led by co-directors John Hobbie and Jerry Melillo. Its mission is to understand how ecosystems are structured and how they to function, to predict their response to changing environments, apply the best scientific knowledge to the preservation and management of natural resources, and to educate scientists and citizens of the future.

In 2002, the Center continued

the Semester in Environmental Science. This program brings undergraduates from a consor- tium of nearly 60 small liberal arts colleges and universities to the for an inten- MBL campus Eel grass. Rick Crawford sive introduction to environmen-

tal sciences.

The complex nature of modern CO-DIRECTORS research a ecosystems requires John E. Hobbie M. multi-disciplinary collaborative Jerry Melillo to address a of approach variety SENIOR SCIENTISTS questions. Accordingly, Center John E Hobbie Charles S. scientists collaborate on more Hopkinson Jerry M. Melillo than 60 projects. We conduct Knute J. Nadelhoffer Centers C V. Starr Bruce J. Peterson The Ecosystems Building our field studies in many Edward B Rastetter locations, from the North Gaius R Shaver American and European Arctic to Brazil, from the temperate forests of ASSOCIATE SCIENTISTS to the estuaries of the eastern U.S. New England Linda A- Deegan Anne E. Giblin

in 2002 was the effect that a warmer climate One question addressed ASSISTANT SCIENTISTS will have on the high amounts of organic matter accumulated in forest Christopher Neill Joseph J. Vallino soils over the centuries. If microbes decompose most of the organic matter, the forests would switch from a global sink of carbon dioxide SENIOR RESEARCH SPECIALIST gas to a source causing an acceleration of global warming. Jerry Paul A Steudler Melillo and Paul Steudler of the Center have collaborated with Univer-

in a in which sity of New Hampshire scientists decade-long experiment of similar the soil of 6 x 6 m plots was heated 5 above the temperature soil did accelerate soil control plots. They found that warming organic matter decay and carbon dioxide fluxes to the atmosphere but that the to response was small and short-lived because microbes were able decompose only a small proportion of the total organic matter. R9

Robert Holmes at the Yem'sey River, Russia

International Study Shows River Discharge in Arctic Ocean is Increasing

Researchers from The Ecosystems Center, along with an interna- Another microbes in nature. question investigated tional team of hydrologists and oceanographers, have docu- These are responsible for many of the transformations in mented that the flow of freshwater from Arctic rivers into the recent decades. the carbon and nitrogen cycles that control important Arctic Ocean has increased significantly over If the trend continues, some scientists predict this could impact ecological processes such as carbon storage and nutrient the to the of the global climate, perhaps leading cooling recycling. This study looked at the link between Northern Europe. structure of the microbial populations in an Arctic lake and seasonal This research, carried out changes. by Byron Ecosystems Center researchers Bruce Peterson, Robert (Max) Crump and John Hobbie Holmes, and James McClelland led the team of scientists from of the Center, could only the United States, Russia, and Germany. They analy2ed discharge data from the six Eurasian rivers that drain into the Arctic be done with the assis- largest Ocean. These rivers, all located in Russia, account for more than tance in molecular tech- 40% of total riverine freshwater inputs to the Arctic Ocean. niques from Mitch Sogin of Center. the Bay Paul New Peterson and his colleagues found that combined annual from 1936 to techniques allowed the discharge from the Russian rivers increased by 7% that this measured increase in runoff is an identification of microbes 1999. They contend observed confirmation of what climatologists have been saying and species changes, for that freshwater to the Arctic Ocean and North An Ecosystems scientist years inputs which is the first step "If the observed collects samples from the Atlantic will increase with global warming. River in Alaska towards the goal river Kuparuk long-term positive relationship between global temperature and of linking species to discharge continues into the future, Arctic river discharge may increase to levels that Atlantic Ocean circulation and ecological function. The study, the first of its kind for impact climate within the 21st century," says Peterson. lakes, revealed that there was a resident population of bacterial species throughout the year. However, a

when Continued. . . distinctly different group of species appeared large amounts of organic matter entered the lake during the and spring meltwater runoff. This organic matter, perhaps the bacteria, came from the litter and soil in the of the plant This project was funded by the Arctic System Science Program surrounding watershed. National Science Foundation. RIO

Arctic River Discharge, continued

Staff flow to | A significant increase v.vater

the Arctic Ocear : }wn or shut off the formation :3ntic Deep RESEARCH STAFF Martin Sommerkom, Postdoctoral Scientist Water. The drivir ! -ehind the great Ahrens, Research Assistant Erica L. Stieve, Research Assistant " Toby -sit" current known underwater Michele P. Bahr. Research Assistant Kristin S. Tholke, Research Assistant

as thermoh.- Nation. Thermohaline Jonathan P. Benstead, Postdoctoral Scientist Suzanne M Thomas, Research Assistant R. Postdoctoral Scientist circuL risible for moving great Neil D. Bettez. Research Assistant Craig Tobias, Zy F. Biesinger, Research Assistant Jane Tucker. Research Assistant amounts c mal energy around the Mary S. Booth, Postdoctoral Scientist Zhenwen Wan, Postdoctoral Scientist influencing the climate. globe, planet's Laura C. Broughton, Postdoctoral Scientist Ian J. Washboume, Research Assistant One of the potential effects could be Donald W. Burnette, Research Assistant Michael R Williams, Postdoctoral Scientist Postdoctoral Scientist cooling of Northern Europe. Elizabeth H. Burrows, Research Assistant Yuriko Yano, Alvarus S. K. Chan. Postdoctoral Scientist Qianlai Zhuang, Postdoctoral Scientist Benjamin P. Colman, Research Assistant Data analyzed in this study, published in Christopher P. Crockett, Research Assistant ADJUNCT SCIENTISTS the December 13, 2002, issue of Science Byron Crump, Postdoctoral Scientist Robert W. Howarth, Cornell University magazine, is important because it Jeffrey A. Evans, Research Assistant Paul A. Colinvaux. Smithsonian Tropical Research Associate Research Institute (retired) represents net precipitation (precipitation Benjamin Felzer, Solange Filoso, Postdoctoral Scientist minus evapotranspiration) over a vast area, Robert H Garritt, Research Assistant VISITING SCIENTISTS in contrast to point measurements of Marcus O. Gay, Research Assistant James Galloway, University of Virginia precipitation and evapotranspiration which Joshua H. Goldstein, Research Assistant Robert Naiman, University of Washington are difficult to extrapolate to a large area. Adrian C- Green, Research Assistant Heather Haas, Postdoctoral Scientist ADMINISTRATIVE STAFF Diana C Garcia-Montiel, Staff Scientist Kenneth H. Foreman, Associate Director, "These data are a unique measure of an Darrell A. Herbert, Staff Scientist Semester in Environmental Science Program environmental trend both in terms of how Robert M. Holmes, Staff Scientist Dorothy J Berthel, Administrative Assistant long the time series is and in that it Shaomin Hu, Research Assistant Anthony J Cave, Research Administrator E. Staff Scientist Suzanne J Donovan, Executive Assistant integrates over a vast area rather than just Jeffrey Hughes, Samuel Kelsey, Research Assistant Frances Johnson-Horman, Administrative measuring a precipitation trend at a few David W. Kicklighter, Research Associate Assistant locations," co-author Stefan says Bonnie L- Kwiatkowski, Research Assistant Guillermo Nunez. Research Administrator Rahmstorf of the Potsdam Institute for James A Laundre, Research Assistant Deborah G Scanlon, Executive Assistant Climate Impact Research. Corey R. Lawrence, Research Assistant Mary Ann Seifert, Administrative Assistant John M. Logan, Research Assistant Ann L. Lezberg, Research Assistant CONSULTANTS Project scientists are hopeful that this Heidi Lux, Research Assistant Francis P. Bowles, Research Designs which links the work of study, hydrologists Roxanne Marino, Staff Scientist Margaret C. Bowles and oceanographers, will stimulate the two James W McClelland, Postdoctoral Scientist fields of science to better communicate Patricia Micks, Research Assistant Sarah Morrisseau. Research Assistant their scientific findings with each other. The Marshall L Otter. Research Assistant will focus their future work on the group Suzanne Randazzo, Research Assistant links between the atmospheric, continen- Heather M. Rueth, Postdoctoral Scientist tal, and oceanic components of the Arctic Diane M Sanzone, Postdoctoral Scientist Carol Schwamb, Assistant hydrologic cycle and on the biogeochemi- Laboratory Karie A. Slavik, Research Assistant Boardwalks protect vegetation from distur- cal tracers that allow scientists to follow bance at research sites in the Arctic heath and the circulation of riverine freshwater mountain birch ecosystem around the Abisko throughout the northern oceans. This Naturvetenskapliga Station in northern research is needed to better understand Sweden. Plots shown here are part of a pilot soil-warming project begun dunng 1 993 at the current functioning of the linked land- Abisko, Rose Crabtree ocean-atmosphere hydrologic system and improve confidence in predictions of the future behavior of the vvstem.

. A researcher from .';: . osystems Center collects water from a stream in the Ipswich River watershed in the Plum Island Ecosystem Long Term Ecological Research site in northeastern

Massachusetts. Investigators study different land uses and their impacts on nutrient loading into the estuaries of Plum Island Sound. Rll

The Ecosystems Center's Long-Term Ecological Research site at Toolik

Lake, Alaska, Knute Nadelhoffer

Publications

K. J. 2002. The J. M. C. Barren, S., C. F. Weber, R. Marino, E. A. Currle, W. S., and Nadelhoffer. Felzer, B. S., D. W. Kicklighter, Mellllo, Davidson, G. Tomasky, and R. W. Howarth. Imprint of land use history: patterns of carbon Wang, Q. Zhuang, and R. G. Prlnn. 2002. Ozone in debris at the and Carbon 2002. Effects of varying salinity on phytoplank- and nitrogen downed woody Effects on Net Primary Production 5:446-460. United States ton growth in a low-salinity coastal pond under Harvard Forest. Ecosystems Sequestration In the Conterminous No. two nutrient conditions. Bfol. Bull. 203: 260-261 . Using a Biogeochemistry Model. Report 90,

Currie, W. S., K. J. Nadelhoffer, and B. Colman. MIT Joint Program on the Science and Policy of

1 tracers Into Bashkln, V. N., and R. W. Howarth. 2002. 2002. Long-term movement of 5N Global Change, Cambridge, MA. under elevated N Modern Biogeochemistry. Kluwer, Dordrecht. fine woody debris chronically 238: 31 3-323. C. 2002. of human S61 pp. inputs. Plant Soil Garcia-Montiel, D. Legacy activity in the present neotropical forests. Pp. 97-

A. D. I. Bettez, N., P. Rublee, W. J. O'Brien, and M. C. Dargaville, R. J., M. Heimann, McGuire, 1 16 in Ecology and Conservation of Neotropical Miller. 2002. Changes in abundance, composi- C. Prentice, D. W. Kicklighter, F. Joos, J. S. Forests, M.R. Guariguata and G.H. Kaftan, eds. tion and cont rols within the plankton of a Clein, G. Esser, J. Foley, J. Kaplan, R. A. Meier, Libro Universitario Regional, Cartago, Costa Rica, T. fertilized arctic lake. Freshw. Bio/. 47: 303-311. J. M. Melillo, B. Moore III, N. Ramankutty, (In Spanish) . Reichenau, A. Schloss, S. Sitch, H. Tian, L. J.

and U. 2002. Evaluation D. J. P. A. Boyer, E. W., and R. W. Howarth, eds. 2002. Williams, Wittenberg. Garcia-Montiel, C., Melillo, Steudler, of terrestrial carbon models with C. Neill. 2002. between N O and Global and Regional Synthesis of the Nitrogen cycle and Relationship 2 C0 measurements: results from C0 emissions from the Amazon Basin. Geophys. Cycle. Kluwer, Dordrecht. 561 pp. atmospheric 2 ; transient simulations considering increasing Res. Lett. 29: 14.1 -14.3. climate and land-use effects. Global Boyer, E. W., C. L Goodale, N. A. Jaworski, and CO , 16: 1092. DOI:10.1029/ K. J. E. W. R. W. Howarth. 2002. Anthropogenic nitrogen Biogeochem. Cycles Goodale, C. L., K, Lajtha, Nadelhoffer, 2002. Forest sources and relationships to riverine nitrogen 2001 GM001 426. Boyer, and N. A. Jaworski. nitrogen U. S. watersheds: export in the northeastern U.SA Biogeochem- sinks in large eastern inventory L. A. 2002. Lessons learned: the effects and modeled estimates. 57/58: istry 57/58: 137-169. Deegan, Biogeochemistry of nutrient enrichment on the support of nekton 239-266. salt marsh Bret-Harte, M. S., G. R. Shaver, and F. S. by seagrass and ecosystems. Special Volume. Estuaries 25: P. A. and G. R. Shaver. 2002. Chapin, III. 2002. Primary and secondary stem SCOR Gough, L., Wookey, tundra to growth in arctic shrubs: implications for 727-742. Dry heath arctic responses long-term community response to environmental change. nutrient and light manipulation. Arct. Antarct. Alp. J.Ecol. 90:251-267. Deegan, L. A., A. Wright, S. G. Ayvazian, J. T. Res. 34:211-218. Finn, H. Golden, R. R. Merson, and J. Harrison.

alters T. E. A. R. I. M. Reiter, J. B. Bush, M. B., M. C. Miller, P. E. De Oliveira, and 2002. Nitrogen loading seagrass Grams, E., Kozovits, structure and H. K.-H. P. A. Colinvaux. 2002. Orbital forcing signal in ecosystem support Winkler, M. Sommerkorn, Blaschke, Mar. sediments of two Amazonian lakes. J. of higher trophic levels. Aquat. Conserv. Haberle, and R. Matyssek. 2002. Quantifying Freshw. 12: 193-212. in Plant Biol. 4: Paleolimnol . 27: 341-352. Ecosyst. competitiveness woody plants. 153-158.

D. Whitall, J. Aber, E. M. Clein, J. S., A. D. McGuire, X. Zhang, D. W. Driscoll, C, Boyer, C. C. P. Groffman, K. S. K. J. and P. Kicklighter, J. M. Mellllo, S. C. Wofsy, P. G. Castro, Cronan, Goodale, Hobbie, E., Nadelhoffer, Hogberg. C. and S. nutrients as Jarvis, and J. M. Massheder. 2002. Historical Lambert, G. Lawrence, Hopkinson, 2002. A synthesis: the role of 2002. Pollution: From the on carbon balances in boreal and arctic and projected carbon balance of mature black OHinger. Nitrogen constraints Links - Hubbard spruce ecosystems across North America: the Sources to the Sea. Science regions. Plant Soil 242: 163-170. role of carbon-nitrogen interactions. Plant Soil Brook Research Foundation, Hanover, NH. 242:15-32. Continued... R12

Holmes. R. M.. J W. McClelland. B. J Peterson. I. Howarth. R. W.. D Walker, and A Sharpley 2002 Marino, R., F. Chan, R. W Howarth. M Pace, and A Shiklomanov, A. I Shiklomanov, A. V. Zhulidov, Sources of nitrogen pollution to coastal waters of G. E Ukens 2002. Ecological and biogeochemi- V. V. Gordeev. and N. N. Bobrovitskaya. 20C2. A the United States Estuaries 25: 656-676. cal interactions constrain planlctonic nitrogen circumpolar perspective on fluvial sedimen: flux to fixation in estuaries. Ecosystems 5: 719-725. the Arctic Ocean Global B/o-jeochem. Hughes. J. E,. L A. Deegan, J C Wyda. and A. B E. 10 1029/2001 GB001849 Wright. 2002. An index of biotic integnty based on Mayer. , W. Boyer. C. Goodale. N. A. fish community structure applied to Rhode Island Jaworski, N van Breemen, R. W. Howarth, S P C. S J. J. V?'! Connecticut in G Billen, K K. D. Hopkinson, , and estuaries. Pp. 49-58 Proceed- Seitzmger, Lajtha, Nadelhoffer, 2002 Decomposition of 3 ganic matter ings of the Fifth Biennial Long Island Sound van Dam, L. J Hetlmg, M. Nosil, K. Paustian, and

- from the contine -a Res. II 49: Research Conference 2000, M Van Patten, ed. R. Alexander. 2002 Sources of nitrate in rivers 4461-4478 Connecticut Sea Grant Publication CTSG-01-02. draining sixteen watersheds in the northeastern Stamford, CT. US isotopic constraints Siogeochemistry 57/58: Howarth. R _ nitrogen cycle. 171-197.

. edia of Pp. 429-435 Global Environ- Hughes, J. E., L. A Deegan, M. J. Weaver, and J Vol. Earth N. E R. mental Change. 2, The System: E. Costa. 2002 Regional application of an index of Mayer, B., Jaworksi, Boyer, Howarth, C L S. Biologies! and Ecological Dimensions of Global estuarine biotic integrity based on fish Goodale, Hetling, Seitzinger, G. Billen, R Environmental Change, H. A. Mooney and J.G communities. Estuaries 25: 250-263. Alexander. N. van Breemen. K Paustian. D. van Canadell, eds. Wiley, Chichester. Dam, K Lajtha, and K Nadelhoffer 2002 On the Hughes, J. E.. L A Deegan, J C Wyda, M J feasibility of using the nitrogen and oxygen Howarth. R. W. 2002. Nutrient Over-Enrichment Weaver, and A. Wright 2002. The effects of isotope ratios of nitrate for describing the origin of Coastal Waters in the United States. Steps eelgrass habitat loss on estuarine fish communities of riverine nitrate and N transformations in large Toward a Solution. Pew Oceans Commission, of southern New England Estuaries 25: watersheds. Siogeochemistry 57/58: 238-266. Washington. DC. 235-249 McClelland, J W., and J P. Montoya 2002. Howarth, R. W., E. W Boyer, W. J. Pabich, and J. Hunter- Thomson, K.. J. Hughes, and B. Williams. Trophic relationships and the nitrogen isotopic N. 2002. in in Galloway. Nitrogen use the United 2002. Estuarine-open-water comparison offish composition of amino acids plankton. Ecology States from 1961-2000 and future 83:2173-2180. potential community structure in eelgrass (Zostera marina L.) trends Ambio 31 : 88-96 habitats of Cape Cod Biol. Bull. 203: 247-248. McGuire. A D., C Wirth, M. Apps, J Bennger. J R. M. F. Howarth, W., and D. Rielinger. 2002. Koop-Jakobsen, K., and A. Giblin. 2002. Tidal Clein. H. Epstein, D W Kicklighter, J. Bhatti, From the S. Nitrogen Atmosphere. Understanding flushing of ammonium from intertidal salt marsh Chapin III, B de Groot, D Efremov, W. and Reducing a Major Cause of Degradation of sediments: The relative importance of adsorbed Eugster, M Fukuda, T Gower. L. Hinzman, B our Coastal Waters. Science and Policy Bulletin ammonium. 810). Bull. 203: 258-259. Huntley. G J Jia, E. Kasischke, J Melillo, V. No 8, Waquoit Bay National Estuarine Research Romanovsky, A Shvidenko, E Vaganov, and D. MA. Walker 2002 Environmental Reserve, Waquoit. LaMontagne, M. G., A. E Giblin, and I. Valiela. variation, 2002. Denitrification and the stoichiometry of vegetation distribution, carbon dynamics and R. D. R. 2002. Howarth, W., Scavia, and Marino. nutrient regeneration in Waquoit Bay. MA. water/energy exchange at high latitudes J Veg. Nutrient Pollution in Coastal Waters: Priority Estuaries 25: 272-281. Sci. 13 301-314 Topics for an Integrated National Research

for the United States. R. L. R Program National Levine, U. Y., and B. C Crump 2002. McKane, B., C. Johnson, G. Shaver, K J. Oceanic and Atmospheric Administration, Bacterioplankton community composition in Nadelhoffer, E. B Rastetter, B. Fry, A. E. Giblin, Silver MD. K. J. Springs, flowing waters of the Ipswich River watershed. Kielland, B. L Kwiatkowski, A Laundre, and Biol. Bull. 203:251-252 G Murray 2002 Resource-based niches provide a basis for plant species diversity and dominance in arctic tundra Nature 415: 68-71.

Melillo. J M. 2002 How earnest thou in this

pickle? Pp. 23-31 in Engineering and Environ- mental Challenges: Technical Symposium on Earth Systems Engineering. National Academy Press, Washington. DC.

J. E. B. Reactive Melillo, M , and Cowling 2002 nitrogen and public policies for environmental

protection. Ambio 31 : 1 50-1 58

Melillo, J M..O. Sala, eta/. 2002 Ecosystem services. Pp. 13-18 in Biodiversity: Its Importance to Human Health, E. Chivian, ed. Center for Health and the Global Environment, Harvard Medical School. Boston, MA

Bruce Peterson looks for bryophytes and filamentous algae in the mountain stream at the Ivishak IS N addition site in the Arctic National Wildlife Refuge, Laura Broughton R13

P. H. P. A M C C. A. J. K , D C Piccolo, Mehllo, J M , Steudler, D Aber, Newkirk. Lux, Steudler, Garcia-Montiel, F P. Bowles, C Catricala, A. Magill, T. Ahrens, and S. Neill, J. M. Melillo, B. J Feigl, and C. C. Cerri. Trace gas P Mornsseau 2002. Soil warming and carbon-cycle feedbacks responses of tropical forest and pasture soils to N and to the climate system. Science 298: 2173-2176 fertilization. Global Biogeochem Cycles 16: 10 1029/ 2001 GB001 394. Mulholland, P J.J L Tank, J R Webster, W. B. Bowden, W. K Dodds, S V Gregory. N. B. Grimm, S K Hamilton, S. Twichell, S., S. Sheldon, L. Deegan, and R. Garritt. 2002. L. Johnson, E. Marti, W. H. McDowell, J L. Merriam, J. L. Nutrient and freshwater inputs from sewage effluent Meyer. B. J. Peterson. H. M. Valett, and W M. Wollheim discharge alter benthic algal and infaunaf communities in a 2002 Can uptake length in streams be determined by tidal salt marsh creek. Blot. Bull. 203 256-258 nutrient addition experiments 7 Results from an interbiome N E C. L. N A comparison study J. North Am Benthol. Soc. 21: 544-560 van Breemen, , W Boyer, Goodale, Jaworski, K. Paustian, S P. Seitzinger, K Lajtha, B. Mayer.

Nadelhoffer K J., L Johnson, J. Laundre, A. E. Giblin, and D. van Dam, R. W. Howarth, K, J Nadelhoffer, M. Eve, and G R Shaver. 2002 Fine root production and nutrient use in G. Billen Where did all the nitrogen go? Fate of nitrogen wet and moist arctic tundras as influenced by chronic inputs to large watersheds in the northeastern U.S A. fertilization. Plant Soil 242: 107-113. Siogeochemistry 57/58: 267-293

Novak, J M., and A. S. K. Chan 2002. Development of P- Vitousek, P. M., K. Cassman, C. Cleveland, T. Crews, C. B. R. R L. hyperaccumulator plant strategies to remediate soils with Field, N. B. Grimm. W. Howarth, Marino, Martinelli.

I. excess P concentrations. Grit. Rev. Plant So. 21 : 493-509 E. B. Rastetter, and J. Sprent. 2002. Towards an ecological understanding of biological nitrogen fixation. Y A. D. J. M. S. 57-58: 1-45. Pan, , McGuire, Melillo, D W. Kicklighter, Biogeochemistry

Sitch, and I. C. Prentice. 2002. A biogeochemistry-based R. R successional model and its application along a moisture Weber, C. F., S. Barron. Marino, W. Howarth, G. gradient in the continental United States. J. Veg. Sci. 13: Tomasky, and E. A. Davidson. 2002. Nutrient limitation of 369-382 phytoplankton growth in Vineyard Sound and Oyster Pond, Falmouth, Massachusetts. Bio/. Bull. 203: 261-263

Peterson, B J., R. M. Holmes, J. W McClelland, C. J. Scientists collect K. samples Vorosmarty. I. A Shiklomanov, A. I Shiklomanov, R. B Williams, B. S., J. E. Hughes, and Hunter-Thomson. at the spring stream at the Lammers, and S Rahmstorf 2002. Increasing river discharge 2002. Influence of epiphytic algal coverage on fish Ivishafc IS N addition site in to the Arctic Ocean. Science 298: 2171-2173. predation rates in simulated eelgrass habitats Biol. Bull. the Arctic National 203: 248-249 Wildlife Refuge, Rastetter, E B., and G. I. Agren 2002. Changes in individual Laura Brougnton allometry can lead to species coexistence without niche Williams, M.. Y. Shimabokuro, D. A. Herbert, S. Pardi- separation Ecosystems 5: 789-801. Lacruz, C. Renno, and E. B. Rastetter. 2002 Heterogeneity of soils and vegetation in eastern Rueth, H. H., and J. S Baron. 2002. Differences in Amazonian rain forest: implications for scaling up biomass Englemann spruce forest biogeochemistry east and west and production. Ecosystems 5: 692-704. of the Continental Divide in Colorado, USA. Ecosystems J L A. J. E. and M. J. 5 45-57 Wyda. C . Deegan, Hughes, Weaver. 2002. The response of fishes to submerged Rueth, H. M., J. S. Baron, and L. A. Joyce. 2002. Natural aquatic vegetation complexity in two ecoregions of the resource extraction: past, present and future Pp 85-112 in mid-Atlantic Bight: Buzzards Bay and Chesapeake Bay Rocky Mountain Futures. An Ecological Perspective, J. S Estuaries 25: 86-100 Baron, ed Island Press, Washington, DC Zhuang. Q., A. D. McGuire, J. Harden, K. P. O'Neill, and J. Scavia, D., J C. Field, D. Boesch, R. Buddemeier, V. Burkett, Yane 2002. Modeling the soil thermal and carbon in Alaska. J. D. Canyan, M Fogarty, M. A. Harwell. R. W. Howarth, C. dynamics of a fire chronosequence interior Mason, D. J Reed, T. C. Royer, A H. Sallenger, and J. G. Geophys. Res. 107: 8147. DOI: 10.1029/2001JD001244. Titus 2002. Climate change impacts on U.S. coastal and marine ecosystems Estuaries 25: 149-164. Zwart, G-, B C. Crump, M. Agterveld, F. Hagen, and S. K Han. 2002. Typical freshwater bacteria an analysis of

1 from of Schmidt, I. K., S. Jonasson, G Shaver, A Michelsen, available 6S rRNA gene sequences plankton and A Nordin. 2002 Mineralization and allocation of lakes and rivers Aquat. Microb. Ecol. 28: 141-155. nutrients by plants and microbes in four arctic ecosystems: responses to warming Plant Soil 242: 93-106

Seitzinger, S. P., R V. Styles, E W Boyer, R. Alexander, G. Billen, R. Howarth, B. Mayer, and N. van Breemen, 2002. Nitrogen retention in rivers: model development and application to watersheds in the northeastern U.S. Biogeochemistry 57/58: 199-237 R14

JOSEPHINE BAY F CENTER FOR MOLECULAR E OGY AND EVOLUTION

The underlying theme of the Josephine Bay Paul Center is to explore the evolution and interaction of genomes

of diverse organisms that play signifi- cant roles in environmental biology and

DIRECTOR human health. This dynamic research Mitchell Sogin program integrates the powerful tools of molecular SENIOR SCIENTISTS genome science, Stephen Hajduk phylogenetics, and molecular ecology Monica Riley to advance our understanding of how

ASSISTANT SCIENTISTS living organisms are related to each Giardia lamblia. Barb Davids (UCSD) Michael Cuirtmings other, to provide the tools to quantify and Robert Sabatmi assess and to Jennifer Wernegreen biodiversity, identify genes and underlying mechanisms of biomedical importance. Life at the Extremes Molecular Technology Uncovers Astonishing Diversity in Spain's Three interlocking programs define the scope "River of Fire" of research in the Bay Paul Center. They are conditions are for bacteria, and the Program in Global Infectious Diseases, the Living tough algae, other microscopic organisms in the Rio Tinto, the Program in Molecular Evolution, and the highly acidic, vividly crimson river that flows through Program in Molecular Microbial Diversity. This the countryside of southwestern Spain. Mined has in past year marked significant growth the since 3000 B.C., the Rio Tinto contains heavy metal Bay Paul Center. We attracted Mat Meselson's concentrations that are several orders of magnitude than those of fresh water. New molecular evolution program to the MBL. higher typical findings from the Rio Tinto, published in the May 9, Meselson is an esteemed member of the 2002, issue of the journal Nature, present the first National Academy of Science and in collabo- molecular description of eukaryotes in a highly ration with David Mark Welch and Jessica acidic, high metal environment and reveal the Mark he has established a Welch, molecular River's incredible eukaryotic diversity. The results evolution in the Paul Center that show that to extreme conditions is much Ocean-dwelling ancantnanan, group Bay adaptation Linda Amaral Zettler more widespread than originally and explores genome evolution in asexual rotifers. expected provide a new understanding of the range of

organisms capable of living at life's extremes and A generous award by the Ellison Medical perhaps on other planets. Foundation allowed us to move forward with a

dramatically expanded program in Global Eukaryota describes those organisms whose genetic material is contained within a membrane-bound Infectious Diseases. This grant provided nucleus. This includes plants, animals, and humans. support for a major renovation that accommo- Previous studies of the Rio Tinto relied on morphol- dates 24 scientists and visitors to the Bay Paul ogy to describe the river's diversity and alerted Center. Dr. Steve is the director of this Hajduk scientists to only a few of the evolutionary similari- new initiative and has brought six graduate ties between its eukaryotic organisms. By examin- and post doctoral fellows to the MBL. His ing the DNA of organisms extracted from the Rio Tmto's sediment and biofilm, the slimy substance research emphasizes the post transcriptional that coats the surface of the River's water and rocks, processing of RNA in African trypanosomes, scientists have uncovered new eukaryotic lineages the cause of human sleeping sickness. RNA R15

editing results in the post-transcriptional insertion or deletion of

nucleotides into mRNA, at specific sites, creating functional open

reading frames. It has been suggested that the enzymes involved in RNA editing might be potential targets for drug development. As part of this major expansion we have recruited two other new investigators to the GID program. Dr. Andrew McArthur has been a Staff Scientist at the MBL since 2000. Andrew directs NIH-funded programs to explore gene expression during different stages of the life cycle of the parasite Giardia lamblia and in Trypanosoma brucei. Robert Sabatini studies the role of unusual base modifications in trypanosomes referred to as "X-base." The enzymes involved in these genetic alterations may be as valuable unique to Trypanosomes and therefore may serve targets Rio Tinto, J. L. de Lope, J. M. Sanchez for drug design.

we offered a new course titled Advances in Genome Sciences Finally, Rio Tinto, continued and Bioinformatics, which is co-directed by Mitchell Sogin of the MBL and Claire Fraser from The Institute of Genome Research (TIGR). that escaped detection by traditional methods. of Important research publications this past year include descriptions The work, led by Linda Amaral Zettler and Mitchell eukaryotic microbial populations that thrive in very acidic environments Sogin of the Josephine Bay Paul Center for Molecular and Evolution, has (pH levels between 1 .7 and 2.2) in the presence of iron concentrations Comparative Biology also revealed that can exceed 20 milligrams/ml; descriptions of eukaryotic diversity in completely new warm, anoxic sediments that are proximal to hydrothermal vents; the eukaryotes as well discovery of introns in the primitive eukaryote, Giardia lamblia; and as others which evidence of lateral transfer of genes from several different bacteria into have never been the genome of Giardia lamblia. seen before in such a highly-acidic environment.

In mapping out the Linda Amaral Zettler. Erik Zettler evolutionary family Camponotus nearcticus, collected in Fa/mouth, MA. Adam Lazarus tree (or phylogeny) for the Rio Tinto, Amaral Zettler, Sogin, and their colleagues have detected a close relationship between the River's acid-loving eukaryotes and other species that prefer neutral environments. The short evolutionary distance between the two tells the scientists that

adaptations are, in addition to being widespread, occurring rapidly when measured on an evolution- ary time scale.

The project was funded by the National Science Foundation's Life in Extreme Environments (or LexEn) Program and NASA's Astrobiology Institute. R16

Staff I Publications

J. RESEARCH STAFF R R. A Palacios, C , and J 2002. Cross, M , Kieft, Sabatini, Dirks-Mulder, Wernegreen c A effect of AT mutational bias Linda Amaral Zettler, Staff I Chaves, and P Borst 2002 J-binding protein strong on David Beaudom, Research A: increases the level and retention of the unusual ammo acid usage in Buchnera is mitigated at 19 Steven J. Biller, Resean. base J in trypanosome DNA Moi Microbiol high-expression genes. Mol. Biol. Evol Amy Crump, Resear 46: 37-47 1575-1584

- Patrick Degnan, : Distant I

.. L H -R Scientist Podar, M , P S Ashita Dhillon Dehal, P., Y Satou, R. K. Campbell, J. Chapman, Mullmeaux, Huang, Daniel Golde :., ate Student B Degnan, eta). 2002. The draft genome of Perlman, and M L Sogin 2002 Bacterial

: II II introns in a Sulip Gosv -earch Assistant Ciona intestina/is insights into chordate and Group deep-sea hydrothermal vent environment Environ. Microbio/ Josh Herb ...itdoctoral Scientist vertebrate origins. Science 298 2157-2167. App/

> I Jennifer , ih, Research Assistant 68: 6392-6398

Assistant II Ulandt Kim, Research Edgcomb, V P., D T Kysela, A. Teske, A.

I R , J H Abby Laatsch, Research Assistant de Vera GUmez, and M. L. Sogin 2002 Benthic Sabatini, N Meeuwenoord, van Boom,

Research Assistant I and P. Borst 2002 of base J in Erica Lasek-Nesselquist, eukaryotic diversity in the Guaymas Basin Recognition

Adam Lazarus, Research Assistant I hydrothermal vent environment Proc Nat/. duplex DNA by J-bmding protein J Biol Chem Bruce Luders, Research Assistant II Acad. Sci. USA 99: 7658-7662. 277 958-966. Jessica Mark Welch, Postdoctoral Scientist

II R N J. H van David Mark Welch, Staff Scientist Edgcomb, V. P., A. G. B. Simpson, L. A. Amaral Sabatini, , Meeuwenoord, Boom, Andrew McArthur, Assistant Scientist Zettler, T A. Nerad, D J Patterson, M E and P. Borst. 2002 Site-specific interactions of

II JBP with base and moieties in Hilary Morrison, Staff Scientist Holder, and M. L Sogin 2002 Pelobionts are sugar duplex

Maria Research Assistant I J-DNA. J. Bio/. Chem. 277 28,150-28,156 Murray, degenerate protists: insights from molecules and Daniel Myers, Lab Assistant morphology Mol Bio/. Evol. 19 978-982 Laila Nahum, Postdoctoral Scientist Simpson, A. G- B., L A. Amaral Zettler, F. Lorraine Olendzenski, Postdoctoral Scientist M. P. Perez- Gomez, E Zettler, B G Keenan, R Amils, and Garcla-Verela, M , Cummings, G Bertil Olsson, Senior Research Assistant Ponce de Leon, S L Gardner, and J. P Laclette M L Sogin 2002 Heavy-metal, acid-loving " Assistant II from "River of Fire Nature Sarah Pacochal, Research 2002 Phylogenetic analysis based on 18S eukaryotes Spain's 417 137 Carmen Palacios, Postdoctoral Scientist nbosomal RNA gene sequences supports the Gretta Serres, Staff Scientist I existence of class Polyacanthocephala A G. B A J J D Lynn Sherrer, Graduate Student (Acanthocephala) Mol Phy/ogenet. Evol Simpson, , Roger, Silberman,

Jillian Ward, Research Assistant I 23: 288-292. D D Leipe, V. P. Edgcomb, L. S Jermnn, D J Patterson, and M L Sogin 2002. Evolutionary VISITING SCIENTISTS Laan, M., H. Richmond, C. He, and R K history of "early diverging" eukaryotes. the Maristela Camargo, University of Sao Paolo, Campbell 2002 Zebrafish as a model for excavate taxon Carpediemonas is a close relative Brazil of Giardia. Mol Biol. Evol. 19: 1782-1791 vertebrate reproduction characterization of Robert Campbell, Ares Pharmaceutical the first functional zebrafish (Danio reno) of D. A. G. S. G. Svard, Lynne McAnelly, University Texas, Austin gonadotropin receptor Gen. Comp. Endocnnol Sun, C.-H., Palm, McArthur, 125: 349-364. and F G Gillin 2002 A novel Myb-related ADJUNCT SCIENTISTS protein involved in transcnptional activation of Matthew Meselson, Harvard T J D. E -L in Giardta lamblia Mo/. University Langford, D , Silberman, M encystation genes 97 1-984 Roger Milkman, Professor Emeritus, University Weiland, S G Svard, J.M McCaffery, M L Microbio/- 46: of Iowa Sogin, and F D Gillin 2002 Giardia lamblia

I L B A K, Harold Zakon, University of Texas, Austin identification and characterization of Rab Tamas, , Klasson, Canback, Naslund, A S J J P. and GDI proteins in a genome survey of the Eriksson, Wernegreen, Sandstrom, INTERN N A and S G Andersson 2002 50 HIGH SCHOOL ER to Golgi endomembrane system. Exp Moran, Alexandria Papa Parasite/ 101: 13-24 million years of genomic stasis in endosymbtotic bacteria Science 296- 2376-2379

VISITING UNDERGRADUATE H G G R K. Morrison, , Zamora, Campbell, Alissa K -U V A de Cohen and M. L. Sogin. 2002 Inferring protein function Teske, A., Hmrichs, Edgcomb, from genomic sequence Giardia lamblia Vera Gomez, D. Kysela, S P. Sylva, M. L Sogin, and H Jannasch 2002 Microbial HHMI SUMMER UNDERGRADUATES expresses a phosphatidyhnositol kinase-related W diversity in the Sarah Biber kinase similar to yeast and mammalian TOR. of hydrothermal sediments Guaymas Marsha Wheeler Basin: evidence for anaerobic Comp. Siochem Physio/. B Siochem Mol Biol. methanotrophic 133:477-491 communities App/. Environ. Microbiol. NATIONAL SCIENCE FOUNDATION 68: 1994-2007 RESEARCH EXPERIENCE FOR Nixon, J E J,A Wang, J. Field, H G Morrison, J J 2002. evolution in UNDERGRADUATE STUDENTS A G McArthur, M. L Sogin, B J Loftus, and J Wernegreen, Genome Chad Brock Samuelson. 2002 Evidence for lateral transfer of bacterial endosymbionts of insects Nat Rev. Andrew Magis genes encoding ferredoxins, nitroreductases, Genet 3: 850-861 Amy McCurley NADH oxidase, and alcohol dehydrogenase 3

John Sander J J , A. B and P. H from anaerobic prokaryotes to Giardia lamblia Wernegreen, Lazarus, 2002 Small of Candiclatus and Entamoeba histolytica Eukaryotic Cell Degnan genome

ADMINISTRATIVE STAFF 1 181-190 b/ochmannia, the bacterial endosymbiont of Pauline Lim Camponotus, implies irreversible specialization

Tara Nihill J E J A H A. G. to an mtracellular lifestyle Microb/o/ogy 148: Nixon, , Wang, G Morrison, 2551-2556. McArthur, M. L Sogin, B Loftus, and J Samuelson 2002 A spliceosomal mtron in Giardia intestina/is. Proc. Nat/. Acad. Sci. USA 99 3701-3705 R17

ARCHITECTURAL DYNAMICS IN LIVING CELLS PROGRAM

The Architectural Dynamics in Living Cells Program, established at the MBL by Dr. Shinya Inoue in 1992, continues the pioneering

research and educational activities in biophysical inquiries directly

in living cells that Dr. Inoue started at Princeton University in

1949. The Program focuses on architectural dynamics in living cells the timely and coordinated assembly and disassembly of macromolecular structures essential for the proper functioning

M/crotubu/es radiating in and differentiation of cells, the spatial and temporal organization DISTINGUISHED SCIENTISTS all directions from a of these structures, and their physiological and genetic control. Inoue centrosome, Rudolf Shinya is also devoted to the and Oldenbourg, with Robert The Program development application SENIOR SCIENTIST E. Palazzo of new tools that such studies in powerful imaging permit directly Rudolf Oldenbourg living cells and functional cell-free extracts. Program members STAFF SCIENTIST II have in the use of for special expertise polarized light analyzing Michael Shribak the local arrangement of molecular bonds and fine structure in biological specimens. Unique instrumentation developed by Program members include the universal light microscope,

centrifuge polarizing microscope, the liquid-crystal based Pol- Scope, and related technology. Biological phenomena currently under investigation include mitosis/meiosis and related motility, amoeboid movement, microtubule-centrosome interaction, and

optical properties of green fluorescent protein. The Architectural Meiosis II in spermatocyte of

the crane fly, recorded with the Dynamics in Living Cells Program is an active component of the new Pol-Scope, James R. MBL's resident cell research group and promotes interdisciplinary Lafountain (U. at Buffalo) and Rudolf Oldenbourg research and training among its resident core researchers, visiting

investigators, and collaborating manufacturers. R18

Polarized fluorescence of single crystal of GfP rotated between parallel polarizers, Shinya Inoue

|Pub//cat/ons

Inoue, S. 2002. Polarization microscopy. In Current Protocols in Cell Biology, Suppl. 13, J. Lippincott-Schwartz, ed. John Wiley & Sons, pp. 4.9.1-4.9.27.

Inoue, S., O. Shimomura, M Goda, M. Shribak,

and P.T. Tran. 2002. Fluorescence polarization of green fluorescent protein (GFP) Proc. Nat/. Acad. So. USA 99(7): 4272-4277.

Inoue, S., and T. Inoue. 2002. Direct-view high- speed confocal scanner theCSU-10. In Cell Biological Applications of Confocal Microscopy, 2nd Edition, B. Matsumoto, ed. Academic Press, pp. 87-123.

Oldenbourg, R 2002. Retardance measurement method. US Patent, Number 6,501,548. USA, Assignee: Cambridge Research & Instrumenta- tion Inc. (Woburn, MA).

Shribak, M., S. Inoue, and R. Oldenbourg 2002 Polarization aberrations caused by differential transmission and phase shift in high NA lenses theory, measurement and rectification. Opt. Eng. 41(5):943-954.

I Staff

Shribak, M. I., and R. Oldenbourg. 2002 Scanning aperture polarized light microscope: RESEARCH STAFF observation of small calcite crystals using Diane Baraby, Research Assistant oblique illumination. In Three-Dimensional and Grant Harris, Software Engineer Multidimensional Microscopy: Image Acquisition Robert Knudson, Instrument Development Engineer and Research Associate and Processing IX, J.-A. Conchello, C. J. Gwen Szent-Gyorgyi, Research Assistant Cogswell and T. Wilson, eds. San Jose, Proceedings of SPIE 4621: 104-109. VISITING INVESTIGATORS Michael Bennett, Albert Einstein College of Medicine Shribak. M., and R. Oldenbourg. 2002. Sensitive Michael Braun, Woods Hole Oceanographic Institution measurements of two-dimensional birefringence Robert Campbell, Serono distributions using near-circularly polarized Larry Cohen, Yale University School of Medicine beam. In Polarization Analysis, Measurement and H. Makoto Goda, Japan Biological Informatics Consortium, Tokyo, Japan Remote Sensing V, D Goldstein, D. B. Peter Hepler, University of Massachusetts at Amherst Chenault, W Egan and M Duggin, eds Seattle, Joseph Hoffman, Yale University School of Medicine Proceedings of SP/E 4819: 56-67 David Keefe. Rhode Island Women & Infants Hospital James R LaFountain, University at Buffalo Wang, W H., L Meng, R. J. Hackett, R. Un Uu, Rhode Island Women & Infants Hospital Oldenbourg, and D. L Keefe. 2002 Rigorous Jessica Mark Welch, Bay Paul Center, MBL thermal control during intracytoplasmic sperm Timothy Mitchison, Harvard University injection stabilizes the meiotic spindle and Robert Palazzo, Rensselaer Polytechnic Institute improves fertilization and pregnancy rates. Prem Ponka, McGill University, Montreal Fertil. Steril. 77: 1274-1277. Edward D Salmon, University of North Carolina at Chapel Hill Orion Vanderlinde, Florida State University

INDUSTRIAL COLLABORATORS Research and Inc Cambridge Instrumentation, , Wobum, MA Nikon, Japan Technical Video, Woods Hole, MA Yokogawa Electric, Japan Universal Imaging Corporation, Downingtown, PA

ADMINISTRATIVE STAFF Jane MacNeil R19

BOSTON UNIVERSITY MARINE PROGRAM

In 2002, the Boston University Marine Program realized its vision for an expanded research focus in behavioral ecology and population genetics. We appointed two new assistant professors, Paul Barber (Berkely, PhD; Harvard, postdoc) and Gil Rosenthal (University of Texas PhD; UC San

I staff Diego, postdoc). In addition, joint planning and advertising with the MBL's Marine Resources Center resulted in additional strength in this area with DIRECTOR the appointment of MBL associate scientist Gabi Gerlach (University of Jelle Atema, Professor of Biology Konstanz). Their scientific perspectives complement the sensory and FACULTY behavioral ecology strengths in the labs of senior faculty Phil Lobel and Paul Barber, Assistant Professor of Biology Jelle Atema and MRC director, Hanlon. MRC John Finnerty, Assistant Professor of Biology Roger Newly appointed Stjepko Golubic, Professor of Biology senior scientist Rick Goetz further enhances the scientific goals of this Les Kaufman, Associate Professor of Biology research focus. Gerlach and Goetz are both BUMP adjunct professors. Phillip Lobel, Associate Professor of Biology Gil Rosenthal, Assistant Professor of Biology Ivan Valiela, Professor of Biology The coastal ecology program headed by Ivan Valiela flourished with a ADJUNCT FACULTY continuous stream of graduate students, postdocs, and international Roger Hanlon, MBL visiting scientists. Its Research Experience for Undergraduates Program Gabriele Gerlach, MBL continues to 10 to Hole Anne Giblin, MBL bring outstanding undergraduates Woods doing Frederick Goetz, MBL research that ends up being published regularly. Anne Giblin of the MBL's Norman Wainwright, MBL Ecosystems Center has an adjunct appointment at BUMP. SENIOR STAFF COORDINATORS Sharifa Gulamhussein With the new faculty, the Program immediately took in a graduate class of Jennifer Ripley 17 highly competitive students for both PhD and Masters degrees, ADMINISTRATIVE STAFF continuing its mission to provide exceptional educational opportunities to Sheri Hall, Program Manager Stefano Mazzilli, Research Assistant, Valiela Lab students in Marine Biology. Several of our current 35 students work Michelle McCafferty, Program Coordinator directly with scientists at the Woods Hole Oceanographic Institution, and the National Marine Fisheries Service.

Continued . .

The undergraduate program also continued its mission successfully by providing eight challenging research-based courses to 16 students

primarily from Boston University. Here too, student research has led to several publications. Cuttlefish embryos. Lisa Kerr Lobel R20

Publications |

T. and Jelle Atema 2002. Armstrong, Peter 8., Margaret Armstrong, Rohrkasse, Sarah M., behavior of whelks. R. L Pardy, Alice Child, and Norman Tracking Busyconinae Bull. 203: 235-236 Wainwright- 2002. Immunohistochemical Bio). in the demonstration of a lipopolysaccharide M. J. and W. E. cell wall of a eukan/ote. the green alga, Rosenthal, G. G , Ryan, loss of Ch/ore/la. Biol. Bull. 203: 203-204. Wagner, Jr 2002 Secondary in the preference for swords pygmy K and G Gerlach swordtail nigrensis (Pisces: Atema. J , M. Kingsford, Xiphophorus 37-45. 2002. Larval reef fish could use odour for Poeciliidae). Anim. Behav. 63: detection, retention and orientation to reefs.

D. I. A. MacLeod, H. S. Fisher, Mar. Ecol. Prog. Ser. 241: 151-160 Shady, S., from and J. Y. Liang. 2002. Adaptation and chromatic flicker. Barber, P. H., M. K. Moosa, and S. R. invisible luminance Palumbi. 2002. Rapid recovery of genetic J. Vision 2: 68. and diversity on coral reefs and the temporal H. and I. Valiela. scale of larval examples Shriver, A. C., R- Carmichael, BUMP spatial dispersal: Ruth Carmichael, from Krakatau. Proc R. Soc. Lond. B 269: 2002. Growth, condition, reproductive of 1591-1597. potential, and mortality bay scallops. Argopecten irradians, in response to in resources. R. M. V. Erdmann. changes food Barber, P. H , S. Palumbi, eutrophic-driven Staff, continued 279: 21-40. and M. K. Moosa. 2002. Sharp genetic J. Exp. Mar. Biol. Ecol. breaks among populations of a benthic Amee Mehta H. Carmichael, Sara P. RESEARCH TECHNICIANS marine crustacean indicate limited oceanic Suggs, Dianne N.. Ruth Karen Morschauser and and Ivan Valiela- 2002. Effects of Sarah Boyce larval transport: patterns, cause, Grady, Catherine O'Keefe in horseshoe crabs 1 1 : 659-674 individual size on Devin Drown consequence. Mol. Ecol. pairing Janelle Morano Mollie Oremland Biol. Bull 203: 225-227. Aaron Rice David Portnoy Barron, Stacy, Carolyn Weber, Roxanne Deborah Rutecki A. Charette, Marino, Eric Davidson, Gabrielle Tomasky, Testa, Jeremy M., Matthew Andrea Shriver Adarn VISITING FACULTY and Robert Howarth. 2002. Effects of varying Edward R. Sholkovitz, Matt C Allen, Sandia Elizabeth Soule in a low- and W. Herbold. 2002 Dissolved Bill Simmons, salinity on phytoplankton growth Rago, Craig Todd Stueckle two nutrient iron in the subterranean estuary of a National Laboratory salinity coastal pond under cycling Erin Summers Massachusetts Nathalie Ward, Lecturer conditions. Biol. Bull. 203: 260-261 coastal bay: Waquoit Bay, Melissa Sweeny Biol. Bull. 203: 255-256.

PhD STUDENTS Evgenidou, A., and I. Valiela. 2002. UNDERGRADUATE of a and J. L Bowen. 2002, Brendan Anrrett Response of growth and density Valiela, I., Bowen STUDENTS demissa to sources to watersheds and estuaries: Jennifer population of Geukensia Nitrogen Alaina in cover mosaics and losses within Ruth Carmichael Avery land-derived nitrogen loading, Waquoit Role of land Colleen Butler Coast. Shelf So. watersheds. Environ. Pollut. 118: 239-248. Marci Cole Bay, Massachusetts Estuar. Sean Dixon Eric Crandall 55. 125-138 Yael Erlitz K. D Heidi Fisher Valiela, I., J. L. Bowen, and Kroeger. Deirdre Grant Assessment of models for estimation of Sara Grady Gaines, Emily F., Ruth H. Carmichael, 2002. Alfred Huang loads to shallow Kevin Kroeger Sara P. Grady, and Ivan Valiela 2002. land-denved nitrogen Laura Kloepper Geochem. 17: 935-953. Carolyn Miller Stable isotopic evidence for changing estuaries. Appl, Heather Marlow Vanessa Miller-Sims nutritional sources of juvenile horseshoe Melissa Penn M. L. Cole 2002. Elizabeth Neeley crabs Biol. Bull. 203: 228-230 Valiela, I., and Comparative Jason Philibotte William Rowan evidence that salt marshes and mangroves Elisse Ruiz meadows from land- Mindy Richlen Grasso, F. W., and J. Atema. 2002. may protect seagrass James Saenz derived loads Ecosystems 5: 92-102. Gregory Skomal Integration of flow and chemical sensing nitrogen Josiah Sewell robots Molly Steinbach for guidance of autonomous marine Jami Barron, Roxanne Mirta Teichberg Whitney in turbulent flows. Environ. Fluid Mech. Weber, Carolyn F., Stacy Gabrielle Tomasky Kristen Wright 2:95-114. Marino, Robert W. Howarth, Gabrielle Joanna York Julia Young Tomasky, and Eric A. Davidson. 2002 Chandra of in Erik Zettler Ziegler Hunter-Thomson, Kristin, Jeffrey Hughes, Nutrient limitation phytoplankton growth Sound and Pond, Falmouth, and Bradley Williams, 2002. Estuarine- Vineyard Oyster INTERNS STUDENTS SUMMER REU of fish Massachusetts. Biol. Bull. 203: 261-263 MASTERS open-water comparison community Barron Abby Atkinson Stacy structure in eelgrass (Zostera marina L.) Gaines R. H and I. Valiela Andrea Bogomotni Emily habitats of Cape Cod Biol. Bull. 203: Weiss, E. T., Carmichael, Kristin on the Lisa Bonacci Hunter-Thompson 247-248. 2002. The effect of nitrogen loading Jane La Du Chelsea Bouchard-Harnish growth rates of quahogs (Mercenaria Melissa Millman clams arenaria) Jessica Buckingham Millman, Melissa, Mirta Teichberg, mercenaria) and soft-shell (Mya Sarah Rohrkasse Michael Cermak Paulina Martinetto, and Ivan Valiela 2002 through changes in food supply. Aquacu/ture Dianne Suggs land- 1-4. Pieter deHart Response of shrimp populations to 211: Testa James Estrada Jeremy derived nitrogen in Waquoit Bay, Massachu- Weber E. and Christopher Florio Carolyn setts Biol. Bull. 203: 263-264. Williams, Bradley S., Jeffrey Hughes, Williams 2002. Influence of Sophia Fox Bradley Kristin Hunter-Thomson. on fish Sarah Good Philibotte, Jason. 2002 Pelagic larval epiphytic algal coverage predation SUMMER VOLUNTEER habitats. Biol Dawn Grebner duration of the Caribbean wrasse, rates in simulated eelgrass Jillian Barber Andrea Hsu Thalassoma bifasciatum Biol. Bull. Bull. 203: 248-249 Alison Leschen 203: 245-246 Mark Lever SUMMER STUDENT Vanessa Malley RESEARCHERS David Martel Rachel Allen Jillian Barber Margaret Johnson R21

MARINE RESOURCES CENTER PROGRAMS

is for the Staff The Marine Resources Center (MRC) a national center develop- ment and use of aquatic organisms in basic biological research, biomedi- cal research, and fisheries science. The research DIRECTOR/SENIOR aquaculture, programs SCIENTIST focus on biological processes integrated at the level of the whole Hanlon Roger organism. SENIOR SCIENTIST Frederick Goetz We made three primary faculty hires in the 2002: Frederick ASSOCIATE SCIENTISTS research ranks during Goetz, Gabriele Gerlach Senior Scientist; Gabriele Gerlach, Associate Alan Kuzirian Scientist; and Scott Lindell, Research

ASSOCIATE SCIENTIST/ Specialist. In addition, two Assistant VETERINARIAN Professors affiliated with the MRC were hired Roxanna Smolowitz by the Boston University Marine Program: Gil Rosenthal and Paul Barber. Collectively, these hires help establish a critical mass of year-round researchers in the MRC.

Marine Resources Center photos, Elizabeth Armstrong R22

Program in Sensory Biology, Behavioral Ecology & Population Genetics

Our studies of the physiological, sensory and genetic mechanisms of behavior bridge neuroscience, behavior, and ecology. Such an ap- proach allows us (1) to study evolutionary processes of natural and sexual selection that shape the lives of animals and humans, and (2) to investigate the genetic consequences of behavioral interactions in an ecological context, including the population level.

In 2002, using DNA fingerprinting, we discovered that there are five genetic stocks of squids in the northwest Atlantic, and that each stock tends to return to certain spawning grounds each summer. This finding

will not only revise the federal fishery management plan, but also

highlights the sophistication of the squids' sensory and behavioral abilities.

Social signals such as pheromones regulate reproductive behavior in fish as well as in other vertebrates including humans. Using zebrafish, we found that male and female pheromones released during complex behavioral interactions greatly influenced female reproduction. This

research will lay the foundation for future analysis of the genetic of and in vertebrates. MRC Staff, continued background fertility reproduction

Learning and memory experiments centered upon defining the James Carroll, Life Support Technical Assistant Edward Enos, Aquatic Resources Division Superintendent different stages of memory formation. Using the marine mollusc William Grossman, Marine Specimen Collector/Diving Hermissenda, we were able to correlate memory acquisition and Safety Officer with the animals' to an stimulus. Janice Hanley, Water Quality and Animal Health Technician retention responses accessory sensory William Klimm, Licensed Boat - R/V Gemma Captain By quantifying the immunocytochemistry, we demonstrated that levels Scott Lindell, Manager, Aquatic Resource Services and of calexcitin increase and the formation of long- Aquaculture Research Specialist persist during stages Beth Coordinator Linnon, Special Projects term memory. Calexcitin is a key element for regulating internal William Mebane, Aquaculture and Engineering Division calcium release in Superintendent memory acquisition. Gabrielle Santore, Executive Assistant Andrew Sexton, Marine Organism Shipper Daniel Sullivan, Boat Captain Eugene Tassinari, Senior Biological Collector Sean Whelan, Diver/Marine Specimen Collector

SEASONAL EMPLOYEES AND VOLUNTEERS

Amanda Carroll, Intern, Lawrence School Brianne Como, Intern, University of Massachusetts at Dartmouth Jay Dimond, Diver/Collector George Gannon, Intern, Massachusetts Bay Community College Andrew Sterling, Diver/Coilector Christian Sterling, Diver/Collector Monica Weedo.i, Intern, Pratt Institute

Photos by Elizabeth Armstrong R23

Program in Scientific | Aquaculture

This program focuses on biotechnology research, applied research on AMERICORPS VOLUNTEERS (SENIOR MEMBERS) Pat Kosky biomedical and commercial and in organisms, policy development Joan Lemieux both of those areas. The biotechnology research is aimed at basic Haskell Maude Birgit Nelson mechanisms that control growth, behavior, reproduction, and disease Joseph Sheeny in commercially important finfish and shellfish. This includes studies on Judith Sheehy Wynne novel regulators of growth and reproduction in fish and shellfish, Joyce pathogen-regulated genes in fish, and the development of molecular- of Han/on based diagnostic techniques. Laboratory Roger

STAFF In 2002, with collaborators in Spain, we established for the first time Roger Hanlon, Senior Scientist Jean Boal, Adjunct Scientist in fish a cell culture to obtain differen- any species primary technique Kendra Buresch, Research Assistant tiated trout macrophages. We then demonstrated that only these Martha Delaney, Research Assistant Chris Florio, Graduate Student, Boston University differentiated macrophages can respond to pathogenic antigens by Nicole Gilles, Research Assistant upregulating early response genes such as tumor necrosis factors and Mary Beth Saffo, Adjunct Scientist Nadav Shashar, Adjunct Scientist interleukins. It will now be possible to use global genomic techniques Mollie Tubbs. Research Assistant to obtain all of the macrophage genes that are regulated by antigen VISITING INVESTIGATORS exposure and this is being pursued. Chuan-Chin Chiao, Postdoc, Howard Hughes Medical Institute We received funding from the Southeastern Massachusetts Aquacul- Melissa Grable, Graduate Student, Boston University Marine Program ture Center and developed new technology to help commercial Nuutti Kangas. Postdoc, Academy of Finland shellfish growers overwinter quahog clam seed, which will circumvent Miranda Karson, Graduate Student, Michigan State University the 60-80% "winter-kill" common in field-planted seed. Allen Mensinger, University of Minnesota at Duluth Marie-Jose Naud. Graduate Student, Flinders University Andrew MMBR Student, of The Policy Center for Marine Biosciences and Technology, directed by Simpson, University California, Santa Barbara former MBL Director Harlyn Halvorson, has now been aligned jointly INTERNS with the University of Massachusetts (Boston) and the Marine Angela Abbott, Massachusetts Maritime Academy Resources Center. The Center defines in the Policy major problems Melissa Cox, Purdue University fields of marine aquaculture and biotechnology, and conducts Robert Nobuhara, Colorado State University Reshma Patel, Emory University international to address these societal issues. workshops important Camille Riviere, EN. S.A.I. A. Eric Stone, University of Massachusetts, Dartmouth Kate Sweeney, Colby College

Photos by Elizabeth Armstrong Continued. . . R24

| Publications

Laboratory of Alan Kuzirian

2002 Larval reef STAFF Atema. J., M. J Kingsford. and G. Gerlach. Alan Ku:inan, Associate Scientist fish could use odour for detection, retention and orientation Hemant Chikarmane, Investigator to reefs. Mar. Ecol. Prog. Ser. 241: 151-160. Herman Epstein, Investigator Hanlon. Basil, J. A., G. 8. Lazenby, L. Nakanuku, and R T. VISITING INVESTIGATORS 2002 Female Nautilus are attracted to male conspecific Frank Child odor. Bull. Mar. Sd. 70: 217-225 of Health John Clay, National Institutes Institute for Basic Research A. M. Kuzirian. 2002 Effects Robert Gould, New York State Borley, K. A., H. T Epstein, and of a sensory block on calexcitin levels in the photoreceptors INTERNS of Hermissenda crassicornis. Biol. Bull. 203: 197-198 Kimberly Borley, Ohio University Williams University R and Alan M. Kuzirian 2002. Trafficking of Alex Hangsterfer, Roger Clay, John , Maritime Hsc70. J. Neurosci. Res. Justin Walker, Massachusetts Academy axonal K' channels potential role of 67: 745-752.

N. J. Lusk-Yablick, Laboratory of Roxanna Smolowitz Delaney, M., C Follet, N. Ryan, Hanney, and G. Gerlach. 2002 Social interaction and distribution of STAFF female zebrafish (Danio rerio) in a large aquarium Biol. Bull. Roxanna Smolowitz, Veterinarian 203: 240-241. Kevin Uhlinger, Research Assistant Gerlach, G., and S Bartmann. 2002 Reproductive skew, in wood INTERNS costs and benefits of cooperative breeding female Member Behav. Ecol. 13 408-418 Krystal Baird, AmeriCorps mice (Apodemus sylvaticus). Amy Hancock, Summer Veterinary Intern Member N. N. L. Gilles, C.-C. Chiao, and R Jen Hsieh, AmeriCorps Grable, M M , Shashar, Andrea Hsu, Graduate Student, Boston University T. Hanlon. 2002 Cuttlefish body patterns as a behavioral Biol. Bull. 203: Kyle Hunt, Mashpee High School assay to determine polarization perception. 232-234

of Frederick Coetz K. R. T. Hanlon 2002 features of the Laboratory Hall, C , and Principal of the mating system of a large spawning aggregation giant STAFF Australian cuttlefish Sepia apama (Mollusca: Cephalopoda) Frederick Goetz, Senior Scientist Mar. Biol. 140: 533-545. Scott Lindell, Manager, Aquatic Resource Services R. Smolowitz, K. R. and Aquaculture Research Specialist Hsieh, J. L.. H. M. Chikarmane, Uhlinger, Marine models, of Linda McCauley, Research Assistant W. Mebane, and A. M Kuzirian 2002 Microbial analysis JoAnna DeNobi/e, Steven Roberts, Postdoctoral Researcher ozone disinfection in a recirculating seawater system Biol. Irina Chaikhoutdmov, Raquel Sussman Bull 203: 266-267. and Louis Lydia Andrew Sweetman, Graduate Student, University G. of Bergen Kusakabe, M., T, Todo, H. J. McQuillan, F. W. Goetz, and of Notre Dame and of ste- Dimitar Iliev, Graduate Student, University Young 2002. Characterization expression cDNAs in roidogenic acute regulatory protein and MLN64 trout. Endocrmology 143: 2062-2070. Laboratory of Gabhele Gerlach in Roberts, S. B 2002 Charactenzation of growth hormone teleost Oiss. STAFF yellow perch and myostatin in several species Gabriele Gerlach, Associate Scientist Abst. Int. B Sci. Eng 63: 1710 Jenny Lusk-Yablick, Research Assistant the Saffo, M B. 2002 Themes from variation: probing Biol. VISITING INVESTIGATORS commonalities of symbiotic associations. Integr Comp. Thomas Breithaupt, Konstanz University 42: 291-294

and R T Hanlon 2002 INTERNS Shashar, N , C A Milbury, at Amherst and Martha Delaney, University of Massachusetts Polarization vision in cephalopods: neuroanatomical School Chris Follett, Acton Boxborough Regional High behavioral features that illustrate aspects of form and Nick Hanney, Bishop Stang High School function. Mar. Freshwat. Behav. Physio/. 35 57-68 Nick Ryan, Thayer Academy R J. and H. Richmond. 2002 A three- Smolowitz, , Hanley, tumors in zebrafish year retrospective study of abdominal Biol. Bull. maintained in an aquatic laboratory animal facility 203: 265-266.

R C. and E. M. Sunila, I.. N A. Stokes, R Smolowitz, Karney, Burreson. 2002. Haplosporidium costale (seaside organism), in Island a parasite of the eastern oyster, is present Long Sound J. Shellfish Res. 21 113-118 R25

Rat cardiac muscle cell. Peter J. 5. Smith

PROGRAM IN MOLECULAR PHYSIOLOGY

The Program in Molecular Physiology (PMP) brings together a group of (Staff resident and visiting scientists who share common interests in the BioCurrents Research Center (NIH: molecular bases of cellular The several laboratories physiology. making Transport of Bioactive Molecules; Development of Electrochemical and Sensors up the PMP focus on cellular plasticity and the properties of molecular Optical mechanisms. A of are used transport variety experimental approaches DIRECTOR/SENIOR SCIENTIST ranging from molecular and biochemical methodologies, through Peter J. S Smith to advanced and electrochemical tech- biophysics, optical imaging RESEARCH ASSISTANTS niques. An example of a research area spanning the independent Katharine Hammar Laurel Moore laboratories within PMP is the role of metabolism and the mitochon- Richard Sanger drion in health and disease. How, for example, does the mitochondrion TECHNICIAN contribute to insulin secretion, heme synthesis, or channel modulation? Robert Lewis Does the aging process, targeting metabolic disorders, contribute to reproductive and neural malfunction, degeneration, and apoptosis? Laboratory of Peter J.5. Smith: Molecular Physiology of Transport and Sensor Development In addition to our interests in basic biology the laboratories of the PMP SENIOR SCIENTIST carry on a strong tradition within the Marine Biological Laboratory Peter J. S. Smith resident programs for instrumentation development. The BioCurrents STAFF SCIENTIST Research Center a national bioengineering resource of the National Mark Messerli Institutes of Health (NCRR) has pioneered the use of electrochemical POSTDOCTORAL RESEARCHERS sensors to define cellular activity through monitoring conditions in the Abdoullah Diarra extended boundary layer. VISITING SCIENTIST Radwan Khawaled A notable characteristic of the PMP is the extensive year-round collabo- rative outreach to regional universities and hospitals. Members contrib- ADJUNCT SCIENTIST George Holz ute to three Boston based NIH Program Project Grants in protein trafficking, diabetes, and anemia. Collaboration also allows the group to of Stefan Channel rapidly advance in areas of topical interest as with an ongoing Laboratory McDonough: Biophysics initiative to the molecular of the resistant study physiology multi-drug ASSISTANT SCIENTIST transporters, players of critical interest to cancer research and our Stefan McDonough understanding of infectious diseases. Annually, the member laboratories host more than 40 national and international visitors, taking advantage Laboratory of Orian Shirihai: Molecular Physiology of Mitochondria of the unique combination of scientific and technical expertise concen- trated at the Marine Biological Laboratory. Access is provided to ASSISTANT SCIENTIST Orian experimental platforms, cutting edge imaging techniques, and a diverse Shirihai of marine models suitable for both basic and biomedical array studying POSTDOCTORAL RESEARCHERS problems. Strong collaborative and joint research projects are also Sarah Haigh Shana Katzman underway with other members of the resident MBL community the Architectural and the Paul Center. notably Dynamics Program Bay Continued... R26

Staff, continued Publications

R A , and cell RESEARCH ASSISTANTS Cooper, S Jung. 2002 Single electrochemistry. In Encyclopedia of 9 G S Wilson, ed & New York Erica Corson Electrochemistry: (Biochemistry), Wiley Sons, Solomon Graf R. T., L. M. Kauri. G. M. and S -K 2002 Metabolic oscillations Gil Palchik Kennedy, Dahlgren, Jung inp-cells Diabetes 51 (suppl. 1): S152-S161

Liu, L., and David L. Keefe. 2002 Aging-associated aberration in meiosis of from Laboratory for Reprouu /e Medicine: oocytes Senescence-Accelerated Mouse (SAM). Hum. Reprod. 17: 2678-2685. Molecular Physiology of Reproduction

L.. Maria A. James R and David L. Keefe. 2002. An essential role DIRECTOR Liu, Blasco, Trimarchi, for functional telomeres in mouse germ cells during fertilization and early development Dev. David L. Keefe, Adjunct Scientist, Brown University Biol. 249: 74-84.

ADJUNCT SCIENTISTS Liu L, J R. Trimarchi, P. J. S. Smith, and D. L. Keefe. 2002. Checkpoint for DNA integrity at Lin Liu, Brown University the first mitosis after oocyte activation. Mo/. Reprod. Dev. 62 277-288 James Trimarchc, Brown University

Maria A and David L Keefe 2002 of functional for POSTDOCTORAL RESEARCHER Liu, L, Blasco, Requirement telomeres metaphase chromosome alignments and integrity of meiotic spindles EMBO Reports 3: Eva Czerwiec, Brown University 230-234

Liu L, J R. Trimarchi, and D L Keefe 2002 Haploidy but not parthenogenetic activation Laboratory of Ayse Dosemeci: Synaptic Plasticity leads to increased incidence of apoptosis in mouse embryos. Biol. Reprod. 66: 204-210 ADJUNCT SCIENTIST Liu, I I. R Trimarchi. P. J. S. Smith, and D. L Keefe 2002. Mitochondnal dysfunction Ayse Dosemeci leads to telomere attrition and genomic instability Aging Cell 1 40-46.

McDonough, S. I., L. M. Boland. I. M. Mintz, and B. P Bean. 2002. Interactions among toxins that inhibit N-type and P-type calcium channels J. Gen. Physio/. 119 313-328

K. Robinson. R , and M A. Messerli 2002. Pulsating ion fluxes and growth at the pollen

tube tip. (Online]. Science's STKE 2002 (162): PE51.

J. R L. P, Trimarchi, , Liu, J. S. Smith, and D. L. Keefe 2002 Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation. Am J. Physio/. Cell Physio/. 282: C588-C594.

R. P. K P J S. Twig. G , Malchow, Hammar.

Smith, H Levy, and I Perlman 2002 A novel turtle retinal preparation for simultaneously measuring light-induced electrical activity and changes in metabolite levels Biol. Bull. 203 198-200

Representative immunofluorescence images of spindles (green!, actin filaments (red), and chromosomes (blue) of oocytes from young and old mice. Lin Liu R27

A non-adhenng dam (Mya arenaria)

leukemia cell, stained reddish via the LABORATORY OF AQUATIC BIOMEDICINE monoclonal antibody "1E10", atop a mat of spreading, normal clam hemocytes, Carol Reinisch This laboratory is dedicated to using marine invertebrates as biomedical models to study issues of health at %. \ IBM the molecular level. In an embryo model, we are examining how industrial chemicals influence neural and function. development, plasticity, Specifically, polychlorinated biphenyls (PCBs) or chemicals found in the wells of Brick, NJ, a site of autism in children, are added to developing clam embryos and (Staff neuronal development assessed. We evaluate how chemicals pinpoint molecular such as the gene family. We are dissecting how SENIOR SCIENTIST targets p53 chemical Carol L Reinisch p53 gene expression and function are altered by exposure. Currently we are focusing on the p73 gene, which is critically impor- ADJUNCT SCIENTIST tant in neuronal Raymond Stephens. Boston regulating development. University Publication POSTDOCTORAL The second line of research examines the induction of leukemia in RESEARCHERS clams or mussels at industrially polluted sites. We have developed in Jessen-Eller, eta/., 2002. Rachel Cox A new invertebrate vitro technology to grow the tumor cells for genetic analyses. Jill Kreiling member of the p53 gene Alternatives Research and In (Supported by the Development.) family is developm en tally STUDENT and to collaboration with the Division of Fisheries and Oceans (DFO) Canada, expressed responds Daniel Kabat the polychlorinated we are the rate of induction of leukemia in edulis, examining Myt/7us biphenyls(PCBs) Environ. VISITING SCIENTISTS Health 110: 3 the blue mussel. Mussels are placed in both clean and dirty sites in Perspect. Sylvie St Jean. Division of 77-385. Five to six the animals are retrieved Fisheries and Oceans, Canadian harbors. months later, Canada Moncton, and assessed for cancer using a leukemia-specific monoclonal anti- Greg McCallum, Atlantic this laboratory. Thus far we have determined that Veterinary College, body generated by Chartottetown, Prince exposure of mussels to PAHs, PCBs, heavy metals, and other industrial Edward Island, Canada compounds increases both the rate and severity of leukemia. This research is funded by DFO, Canada.

A 72-hour-old Spisula solidissima embryo, stained with an antibody to clam neurofilament/ intermediate filament

protein (NF/IF). Jilt Kreiling

Photo by Elizabeth Armstrong R28

LABORATORY OF BARBARA FURIE AND BRUCE FURIE

P-Carboxyglutamic acid is a calcium-binding amino acid that is found [Staff |Pub/ications in the conopeptides of the predatory marine cone snail, Conus. This ADJUNCT SCIENTISTS has been the of this amino acid in laboratory investigating biosynthesis Barbara C. Furie. Harvard Brown, M., B. Hambe, B. Conus and the structural role of p-carboxyglutamic acid in the Medical School Furie, B. C. Furie, J. Bruce Furie, Harvard This satellite relates to the main Stenflo, and L M conopeptides. laboratory closely Medical School 2002. Detection Stenberg. laboratory, the Center for Hemostasis and Thrombosis Research, on the Alan Rigby, Harvard of vitamin K-dependent Medical School Harvard Medical School in Boston, whose main focus is the proteins in venoms with a campus monoclonal antibody synthesis and function of p-carboxyglutamic acid in blood clotting VISITING SCIENTIST specific for p- Johan Stenflo, of Lund proteins and the role of vitamin K. University carboxyglutamic acid, lexicon 40: 447-453, STAFF SCIENTIST II Eva Czerwiec Until recently, the marine cone snail had been the sole invertebrate Czerwiec, E., G. S. Begley, known to the vitamin amino J. Stenflo, K Taylor, B. C. synthesize K-dependent acid, p-- and B Furie. 2002. Furie, carboxyglutamic acid (Gla), but the work of this laboratory and others Structural similarity and has shown that this in snail functional differences synthetic pathway has been preserved most animal phyla. The cone between invertebrate and produces neurotoxic conopeptides, some rich in Gla, which it injects into its prey to immobilize vertebrate carboxylases: it. To examine the biosynthetic for Gla, we have studied the Conus which expression and character- pathway carboxylase ization of recombinant converts glutamic acid to p-carboxyglutamic acid in the presence of vitamin K. We examined vitamin K-dependent (J- the diversity of animal species that maintain vitamin K-dependent carboxylation to generate glutamyl carboxylase from Conus textile. ur. J. Gla. We have cloned full length carboxylase from the beluga whale (De/ph/napterus /eucas), the Biochem. 269:6162-6172. toadfish (Opsanus tau), and the cone snail (Conus text//e) to compare these structures to the

known bovine, human, rat, and mouse cDNA sequences. In addition, we have partially cloned

the carboxylase gene from chicken (Ga//us gallus), hagfish (Myxine g/ut/nosa), and horseshoe crab (L/mu/us po/yphemus). In addition, the Drosophi/a genome contains the p-carboxylase gene. The predicted amino acid sequence of the carboxylase cDNA from Conus textile shows most regions are nearly identical to the mammalian sequence, and that there is about 40%

sequence similarity. This protein has been expressed, and the recombinant enzyme identified as a carboxylase and epoxidase. These results demonstrate the broad distribution of the vitamin

-dependent carboxylase gene, including a highly conserved motif that is likely critical for Cone snails, Volker Steger enzyme function. The vitamin K-dependent biosynthesis of Gla is a highly conserved function in the animal kingdom and we are now searching for a novel Gla containing protein that is critical for survival of animal species. R29

LABORATORY OF NORMAN WAINWRIGHT

The mission of this laboratory is to understand the molecu- lar defense mechanisms exhibited by marine invertebrates in response to invasion by bacteria, fungi, and viruses.

Their primitive immune systems demonstrate unique and powerful strategies for survival in diverse marine environ- ments. The key model has been the horseshoe crab Limulus polyphemus. Limulus hemocytes exhibit a very sensitive LPS-triggered protease cascade that results in blood coagulation. Several proteins found in the hemocyte and hemolymph display microbial binding properties that contribute to antimicrobial defense. Commensal or

symbiotic microorganisms may also augment the antimi- crobial mechanisms of macroscopic marine species. Secondary metabolites are being isolated from diverse marine microbial strains in an attempt to understand their

role. Microbial participation in oxidation of the toxic gas hydrogen sulfide is also being studied.

Photo by Volker Sieger

I Staff

DIRECTOR/SENIOR SCIENTIST Norman Wainwright Publication |

RESEARCH ASSISTANTS Armstrong, Peter B., Margaret T. Armstrong, R. L Pardy, Alice Child Alice Child, and Norman Wainwright. 2002- Immunohis- Kendra Williams tochemical demonstration of a lipopolysaccharide in the cell wall of a eukaryote. the green alga. CMore/la. Bio/. Bull. VISITING SCIENTIST 203: 203-204. Porter Anderson

Limulus, Volker Steger Limulus trilobites, Beate Mittmann R30

Mertidal mats, John Spear DSS section. Jack D Farmer Crystalline gypsum, John Spear

CENTER FOR ADVANCED STUDIES IN THE SPACE LIFE SCIENCES

In 1995, NASA's life sciences programs and the MBL established a cooperative agreement with the formation of the Center for Advanced Studies in the Space Life Sciences (CASSLS at MBL). CASSLS strives to increase awareness of NASA's life sciences interests and to expand NASA's interactions with talented biologists. In support of these goals in 2002, CASSLS had its busiest year ever with the presentation of Staff several meetings and workshops. Scientific meetings ranged in content from information technology to evolutionary biology, and served more DIRECTOR than 125 participants. Additionally, in another workshop, 17 East Coast Diana E Jennings teachers spent four days learning about astrobiology and space

life sciences. ADMINISTRATIVE ASSISTANT Meeting proceed- Heather K Farrell Three Scientific Conferences were held at the Erik Jonsson Center for ings published in the National of Sciences: The Biological Academy Bulletin:

April 22-24, 2002. "Combating Uncertainty with Fusion," "Limits to Self-Organiza- " in collaboration tion in Biological Systems presented with meeting Chair Misha Pavel, Includes 12 peer-reviewed Ph.D., of the Oregon Graduate Institute articles ranging from computational to behavioral studies of self- May 1-3, 2002. "Outcomes of genome-genome interactions," organizing phenomena. in collaboration with Chair Mitchell Bio/. Bull. 202. 243-320. presented meeting Sogin, June 2002. Ph.D., of the Marine Biological Laboratory

September 22-24, 2002. "Understanding Mechanisms of Evolution," presented in collaboration with meeting Chair Eric Davidson, Ph.D., of the California Institute of Technology

Teacher Enhancement Workshop held at the MBL:

November 22-24, 2002: "Life and Living in Space," co-directed by Diana Jennings and Lorraine Olendzenski R3I

SUMMER AND VISITING RESEARCHERS

Many visiting MBL investigators use marine organisms as models for studying basic biological processes. Research using squids, sea urchins, horseshoe crabs, dogfish, clams, toadfish, and sea slugs, for example, has increased our fundamental understanding of a broad range of diseases and medical conditions including cancer, diabetes,

epilepsy, hypertension, multiple sclerosis, arthritis, and neurological disorders.

During 2002, the MBL welcomed 129 Principal Investigators and 237 other researchers from 124 institutions, representing 12 countries. Members of the summer community come from Harvard and Howard, from the University of Alabama and the Universitat de Barcelona, from the Food and Drug Administration and the National Institutes of Health, from Canada, and Switzerland, among Sea urchin cell, Philip Presley Argentina, England, many other institutions, universities, agencies and countries.

MBL summer researchers find an infrastructure and an informal, interactive scientific community that allows them to launch into research almost immediately upon their arrival. Advice and equipment always seem available from other researchers or from the summer courses. Free from academic duties at their home institutions, some

veteran summer scientists report they do more hands-on research in three months at the MBL than they do during the rest of the year at their home institutions.

Spider crab embryo Gundrun Aspoek R32

Spisub :. - Jissima nuclei, Anne Goldman

Elizabeth Armstrong

2002 Summer Investigators

Armstrong, Clay Burgess, David Douglas, John K. University of Pennsylvania Boston College University of Arizona

Armstrong, Peter B Camargo, Maristela Eckberg, William University of California, Davis University of Sao Paulo, Brazil Howard University

Augustine, George J Canessa, Cecilia Edds-Walton, Peggy Duke University Medical Center Vale University Parmly Hearing Institute of Loyola University Baker, Robert Chang, Fred New York University Medical Center Columbia University Ellenberg, Jan European Molecular Biology Barlow, Jr., Robert B. Chappell, Richard L Laboratory, Germany State University of New York Hunter College, City University of Upstate Medical University New York fay, Richard Loyola University of Chicago Barry, Susan Clay, John Mount Ho/yoke College National Institutes of Health Field, Christine Harvard University Medical School Beauge, Luis Cohen, Lawrence B. Institute de Investigacion Medica Yale University School of Medicine Fields, Douglas "Mercedes y Martin Ferreyra," National Institutes of Health Argentina Cohen, William D. M. Hunter College, City University of Fishman, Harvey Bennett, Michael V. L. New York University of Texas Medical Branch, Albert Einstein College of Medicine Galveston Crawford, Karen Bodznick, David St. Mary's College of Maryland Gadsby, David Wesleyan University The Rockefeller University De Polavieja, Gonzalo Botto, Florencia University of Cambridge, United Galione, Antony Universidad Nacional de Mar del Kingdom Oxford University, United Kingdom Plata, Argentina De Weer, Paul Gandhi, Sunil Boyer, Barbara University of Pennsylvania School The Salt Institute Union College of Medicine Garber, Sarah Brady, Scott T. Denk, Winfried The Chicago Medical School The University of Texas Southwest- Max-Planck-lnstitute for Medical ern Medical Center, Dallas Research, Germany Gerhart, John University of California, Berkeley Brown, Joel Desai, Rooma Albert Einstein College of Medicine Yale University School of Medicine Giuditta, Antonio " Universifa di Napoli "Federico II, Browne. Carole Dickinson, Bonny Italy Wake Forest University School of Children's Hospital Medicine Goldman, Robert D. DiPolo, Reinaldo Northwestern University Medical Burbach, Peter Institute Venezolano School Rudolf Magnus Institute for /nvestigaciones Cientificas, Neurosciences, The Netherlands Venezula Gould, Robert New York State Institute for Basic Burger, Max M Dodge, Frederick Research Novartis International AG, State University of New York Switzerland Upstate Medical University R33

Micnael Groden, Joanna Koonce, Pant, Hansh Sugimon, Mutsuyuki Center New York Medical Center University of Cincinnati Wadsworth National Institutes of Health University

Gruenbaum, Yosef R34

Mitochondria/ dysfunction and oxidative stress lead to te/omere attrition and chromosomal end-to-end fusions (indicated by arrows) in mouse embryos, Lin Liu

MBL Research Fellows

Twenty-two Peter Armstrong, Ph.D. Cecilia M. Canessa, M.D. scientists received University of California, Davis Yale University, New Haven, Connecticut and in awards to conduct His research focused on immune defense proteins "Cloning and characterization of ASIC channels marine " defense of that show evolutionary vertebrates Dr Canessa was funded The Erik B Fries research at the processes arthropods by Laura and conservation. Dr. Armstrong was funded by The Endowed Fellowship, the M.G F. Fuortes Memorial MBL in 2002. Fund. Arthur Colwin Endowed Summer Research Fellowship Fellowship Fund, The Stephen W. Kuffler Fellowship Fund, an MBL Research Fellowship, and the Ann E Kammer Memorial Fellowship Fund Florencia Botto, Ph.D Universidad Nacional de Mar del Plata, Mar del Plata, Argentina Fred Chang, M.D., Ph.D. intertidal on the "The role of burrowing species (e.g., crabs) Columbia University College of Physicians and Surgeons, dynamics of organic matter in estuarine environments." New York, New York " Dr. Botto was funded by the MBL Associates, The Catherine "Placement of the cell division plane Dr. Chang Filene Shouse Foundation, and the Lucy B. Lemann was funded by The Universal Imaging Corporation Fellowship Fund. Fellowship Fund.

J. Peter H. Burbach, Ph.D. Karen Crawford, Ph.D. Institute for Neurosciences Rudolf Magnus University St. Mary's College of Maryland, St. Mary's City, Maryland Medical Center, Utrecht, The Netherlands "Molecular analysis of B-catenin expression, axes formation of the as a model for in "The stellate ganglion squid and early embryogenesis the squid, Loligo pealei, Dr, Burbach was neurodevelopment gene cascades." insights into evolution." Dr Crawford was funded by funded by The Stephen W. Kuffler Fellowship Fund and the the Evelyn and Melvin Spiegel Fellowship Fund, the Baxter Postdoctoral Fellowship Fund. MBL Associates, and the James A and Faith Miller Fellowship Fund

David Burgess, Ph.D. Boston College, Chestnut Hill, Massachusetts Bonny Dickinson, Ph.D. "Cytokinesis in embryonic cells." Dr. Burgess was funded by Harvard Medical School and Children's Hospital, Boston the Josiah Macy, Jr Foundation, the Robert Day Allen "Calmodulm and the unconventional myosins play key roles William Porter Fellowship Fund, and the Townsend in FcRn trafficking by mediating interaction with the actin Foundation. cytoskeleton" Dr Dickinson was funded by The Laura and Arthur Colwin Endowed Summer Research Fellowship, The Frederik B Bang Fellowship Fund, the MBL Associates, and Maristela Camargo, D.V.M., Ph.D. an MBL Research Fellowship. University Sao Paulo, Sao Paulo, Brazil "An evolutive study of Th1/Th2 differentiation." Dr. Camargo was funded by The Catherine Filene Shouse Foundation, The Frederik B Bang Fellowship Fund, and an MBL Research Fellowship R35

John K. Douglass, Ph.D. Oscar Iribarne, Ph.D. University of Arizona, Tucson Universidad Nacional de Mar del Plata, Argentina role of the "An electrophysiological and anatomical study of central "The SW Atlantic intertidal burrowing crab visual pathways in Limulus po/yphemus." Dr. Douglass was Chasmagnathus granu/ata in the dynamics of nutrients." funded by the H. Keffer Hartline Fellowship Fund, the Plum Dr. Iribame was funded by the Lucy B. Lemann Foundation, John E. Dowling Fellowship Fund, and the Fellowship Fund. Herbert W. Rand Fellowship.

Diane Lipscombe, Ph.D. Jan Ellenberg, Ph.D. Brown University, Providence, Rhode Island identification of novel European Molecular Biology Laboratory, "The conus toxins to discriminate Heidelberg, Germany among voltage-gated calcium channels and their splice "Mechanism of nuclear envelope breakdown (NEBD) in variants." Dr. Lipscombe was funded by The Catherine echinoderm oocytes and embryos." Dr. Ellenberg was the Filene Shouse Foundation and the MBL Associates 2002 Nikon Fellow, funded by Nikon Instruments, Inc.

Ido Perlman, Ph.D. Sarah Garber, Ph.D. Technion-lsrael Institute of Chicago Medical School, North Chicago, Illinois Technology, Haifa, Israel "Correlation of ion flux and regulation of cell volume." "Nitric oxide synthesis in the Dr. Garber was funded by The Erik 8. Fries Endowed vertebrate retina and its Fellowship. physiological and cellular " functions Dr. Perlman was funded by The Gruss Upper Yosef Gruenbaum, Ph.D. Foundation. Institute of Life Sciences at The Hebrew University of Jerusalem, Jerusalem, Israel "Molecular and functional dissection of the nuclear lamina Prem Ponka, M.D., Ph.D. in the surf clam." Dr. Gruenbaum was funded by The Gruss McGi/l University, Montreal, Upper Foundation, The Frank R. Lillie Fund, The Erik B. Canada Fries Endowed Fellowship, the Robert Day Allen "Iron Trafficking in Erythroid Cells: " Fellowship Fund, and the H. Burr Steinbach Memorial A Collaborative Program Fellowship Fund- Dr. Ponka was funded by the Frank R. Lillie Fund.

Leah Haimo, Ph.D. University of California, Riverside Nancy Ratner, Ph.D. Her research focused on how molecular motors are University of Cincinnati College of regulated to control organelle transport. Dr. Haimo was Medicine, Cincinnati, Ohio funded by The Laura and Arthur Colwin Endowed Summer The title of her research project Research Fellowship Fund. was "Cyclin-dependent kinases in fast axonal transport." Dr. Ratner was funded by the Frank R. Lillie Jorg Hardege, Ph.D. Fund and The Herbert W Rand Hull University, Hull, United Kingdom Fellowship Fund. "Do sex pheromone differences in Nereidid polychaetes lead to reproductive isolation?" Dr. Hardege was funded Kevin Begos by the Lucy B. Lemann Fellowship Fund, The Charles R. J. Richard Whittaker, Ph.D. Crane Fellowship Fund and The John O. Crane Fellowship University of New Brunswick in Fredericton, New Fund. Brunswick, Canada

"The Sea Squirt's Secret: How We Discovered Our Chordate Ancestry." Dr. Whittaker was funded by the Mary-Ellen Harper, Ph.D. Frank A. Brown, Jr. Readership Fund University of Ottawa, Ontario, Canada "Use and construction of self-referencing microelectro- chemical probes for studies into the role of Uncoupling Protein-3 (UCP3) in myocellular energy metabolism." Dr. Harper was funded by The Laura and Arthur Colwin Endowed Summer Research Fellowship and the H. Burr Steinbach Memorial Fellowship Fund. R36

Grass Fellows

Nine scientists participated in the 2002 Grass Fellowship Program in Neuroscience at the Marine Biological Laboratory. The program is sponsored by The Grass Foundation and offers independent research opportuni- ties to young neuroscientists. The 2002 program was directed by Dr. Susan R. Barry of Mount Holyoke College. Dr. Melissa Ann Vollrath of Baylor College of Medicine was the program's Associate Director.

Gonzalo Garcia Rooma Desai, Ph.D., Yale School of Medicine, de Polavieja, Ph.D., UCLA School of Medicine, "Behavioral and "Isolation of K' Currents Underlying the 'Chopper Algorithm Circuitry for Visual Motion Detection in the Leech" Response' of the Principal Cells of Lateral Superior Olive (LSO)" Dima Rinberg, Ph.D., Bell Laboratories Lucent of Multineuron Sunil Gandhi, The Salk Institute, "Evanescent Wave Technologies, "Optical Recording Ballistic of Sensitive Microscopy of Single Vesicle Recycling in Goldfish Activity Using Delivery Voltage Retinal Bipolar Terminals" Dyes"

Adrian Ph.D., of Matthias Gruhn, Ph.D., Cornell University, Rodriguez-Contreras, University "Intrinsic Distribution "Correlation of Extracellular Nerve Recordings California, Davis, Properties, and of Neurons in the and Behavioral Activity in Live Crayfish Using Morphology Inhibitory Midbrain of Chicken" Implantable Electrodes and High-Speed Auditory Pathway Video Technology" Michael S. Smotherman, Ph.D., UCLA, "Descend- Control of Motoneurons in the Beate Mittmann, Institut fur Biologic, "The ing Chromatophore Brain" Development of the Nervous System in the Cephalopod Horseshoe Crab Limulus po/yphemus (Chemicerata, Damian G. Wheeler, McGill Ziphosura) and its Implication for Arthropod University, from to Relationships" "Multiprotein Complex Signaling Synapse Nucleus"

Limulus centra/ nervous system, Beate Mittmann R37

Other Research Personnel

Abe. Teruo, Niigata University, Japan Ge, Lan, University of California, Riverside Adams, Christina, Williams College Gifford, Raeann, University of Kansas Akingbade, Kathenne, University of Oxford, Gilland, Edwin, New York University School of Medicine United Kingdom Gioio, Anthony, National Institutes of Health Alber, Merryl, University of Georgia Goda, Makoto, Japan Biological Information Research Center, Japan Alimi, Mariam, Wake Forest University Goldman, Anne, Northwestern University Medical School of Alliegro, Mark, Louisiana State University Gomez, Maria del Pilar, Boston University School Medicine

Health Sciences Center Grant, Philip, National Institutes of Health Arnolds, David. Williams College Gratton, Michael Anne, University of Pennsylvania Artigas, Pablo. Rockefeller University Greer, Jonathan, Brown University Asomoah, Nikiya, Williams College Guo, YiFan, Williams College Russia Ayliffe, Harold, University of Utah Gyoeva, Fatima, Institute of Protein Research,

Banta, Gary, Roskilde University, Denmark Hangsterfer, Alexandra, Marine Biological Laboratory H Hull United Marine Bartels-Hardege. , University, Kingdom Hanney, Nicholas, Biological Laboratory Beach, Rebecca, Hollins University Harrington, John, University of California, Davis Bearer, Elaine, Brown University Harwood, Claire, University of Pennsylvania Berbenan, Graciela, Institute de Investigacion Medica Hatoum, Nagi, New York University Medical School "Mercedes y Martin Ferreyra," Argentina Helbig, Anmka, Institut fur Biologische Informationswerarbeltung, Bertetto, Lisa, Wesleyan University Germany Biber, Sarah, Earlham College Hellemons, Anita, Rudolf Magnus Institute for Neuroscience, Binion, Samantha, Emory University The Netherlands

Bodily, Jill, Stanford University Helm, Jessica, Yale University School of Medicine Bordenstem, Seth, Marine Biological Laboratory Hepler, Peter, University of Massachusetts Borley, Kimberly. Ohio University Hernandez, Carlos, New York University School of Medicine Bernstein, Gil, Technion, Israel Hernandez, Ruben, University of Texas Braun, Alexander, Hunter College Hess, Sam, National Institutes of Health Brewton, Luke, University of Texas Medical Branch Hoffman, Mathew, Boston College Brown, Jeremiah, Dartmouth College Holtz, Scott, Northwestern University Medical School Bucior, Iwona, Friedrich Miescher Institut, Switzerland Homsi, Sara, Wake Forest University Horseman, Nelson, University of Cincinnati Cameron, Lisa, Univesity of North Carolina, Chapel Hill Brazil Cameron, Luiz, University of Rio de Janeiro, Iliev, Dimitar, University of Notre Dame Carroll, Amanda, Marine Biology Laboratory

Cefaliello, Carolina, University of Naples, Italy Jackson, Ticaria, Howard University Chaikhoutdin, Irina, Hunter College Johnson, Michael, University of Connecticut Chang, Donald, Kong Kong University, Kong Kong Jurkovicova, Dana, National Institutes of Health Chen, Xiaobing, National Institutes of Health Chiao, Chuan-Chin, Massachusetts General Hospital Katar, Mazkhan, Wayne State University Chludzinski, John, National Institutes of Health Khavandgar, Simin, Albert Einstein College United Churchill, Grant, University of Oxford, Kingdon King, Curtis, University of Utah Clark, Michael, Medical College of Georgia Knowles, James, Colgate University Collis, Leon, University of Rhode Island Koester, Helmut, Baylor College of Medicine Conrad, Mara, Hunter College Konnerth, Arthur, University of Munich, Germany Coric, Tatjana, Yale University School of Medicine Koop-Jabobsen, Ketil, Roskilde University, Denmark Corson, Erica, Mt Holyoke College Couch, Ernest, Texas Christian University Lee, Kyeng-Gea, Hunter College Cox, Melissa, Marine Biological Laboratory Levy, Hanna, Technion, Israel Medical Center Li, YuLong, Duke University De Stefano, Rosanna, University of Naples, Italy Lober, Robert, Medical Collegte of Georgia Delaney, Martha, Marine Biological Laboratory Lockard, Jon, National Institutes of Health of DeNobile, JoAnna, Hunter College Louis, Lydia, Rutgers, The State University New Jersey Dmeen, Shauna, Williams College Lowe, Chris, University of California, Berkeley Djunsic, Maja, Yale University School of Medicine Maddox, Paul, University of North Carolina Ehsanian, Reza, NASA Ames Research Center Marangoni, Maria Natalia, University of Buenos Aires, Argentina Evans. Louise. Harvard Medical School Martinez, Gabnela, University of New Hampshire Eyman, Maria, Universita di Napoli "Fedenco II," Italy Masgrau, Roser, Oxford University, United Kingdom Maude, Haskell, Marine Biological Laboratory Universitat Fernandez-Busquets, Xavier, de Barcelona, Spam Mbanu, Chijioke, Wayne State University Ferrara, Eugenia, Unversita di Napoli "Federico II," Italy McAnelly, Lynne. University of Texas, Austin Fevrier, Salem, Williams College McCurley. Amy, Richmond University Follett, Christopher. Marine Biological Laboratory Molina, Anthony, University of Illinois at Chicago Franzmi-Armstrong, Clara, University of Pennsylvania Momose-Sato, Yoko, Tokyo Medical and Dental University, Japan School of Medicine Montanez, Marlena, Mt Holyoke College Frick, Andreas, Baylor College of Medicine Montgomery, John, University of Auckland, New Zealand Moran, Kimberly, New York University School of Medicine Gainer, Harold, National Institutes of Health Moreira, Jorge, University of Sao Paulo, Brazil Garnham, Give, University of Oxford, United Kingdom Morfini, Gerardo, University of Texas Southwestern Medical Center Garza, John, University of Texas at San Antonio Morgan, Anthony, University of Oxford, United Kingdom Gaszewska, Anna, Medical College of Georgia Morse, Thomas, Yale University

Continued. R38

Institutions Najera, Julia, University of Texas Domestic Represented Nedoluzhko, Aleksey, Wadsworth Cent ,- Ng, Michelle, Boston College Nobuhara, Robert, Colorado S* ersity Albert Einstein College of Medicine Nonaka, Mio, Kyoto Univere^ Arizona State University Normand, Danielle, Unive': Hampshire Health Center Nuccitelli, Richard. Unive' Connecticut Barnard College Baylor College of Medicine O'Neal, Jessie;, scleston Beth Israel Deaconess Medical Center Obata, Shuictv s City University, Japan Boston College

: Urbana Olsen, Gary, Ur.ivei Illinois, Boston University School of Medicine of Irvine Ortiz, Christopi:e., University California, Brown University

Palmer, Luc/, University of Minnesota California Institute of Technology Pascal, Akil, Williams College California, University of, Berkeley Passianoto, Caio, Marine Biological Laboratory California, University of, Davis Patel, Reshma, Marine Biological Laboratory California, University of, Irvine Peacock-Villa, Elizabeth, Dartmouth College California, University of, Los Angeles Pelletier, Cory, Brown University California. University of. Riverside of Health Petersen, Jennifer, National Institutes California, University of, San Francisco Duluth Pollema, Sarah, University of Minnesota, Cincinnati, University of Center Prasad, Kondury, University of Texas Health Science Colorado School of Medicine, University of Columbia University Quigley, James, Scripps Research Institute Connecticut, University of Cornell University Rabbitt, Richard, University of Utah Courant Institute Radojicic, Mihailo, Yale University Redenti, Stephen, Hunter College Dartmouth College of Medical Branch Remick, Kathenne. University Texas Duke University School Rhodes, Paul, New York University Medical Duke University Medical Center Richmond, Hazel, University of Minnesota Ridings, Corey, Occidental College Rieder, Leila, Albany High School Rinkwitz, Silke, New York University Medical School Ripps, Jeff, Towson University Rummel, John, NASA

Sanchez, Carlos, University of Texas Sato, Katsushige, Tokyo Medical and Dental University, Japan Satpute, Prasanna, Brown University Schnackenberg, Bradley, University of Carolina, Chapel Hill Scotto Lavina, Zeno, National Institutes of Health Short, Michelle, Marine Biological Laboratory Shumaker, Dale, Northwestern University Medical School Simpson, Andrew, University of California, Santa Barbara Smillie, Darren, University of Edinburgh, United Kingdom Smith, Kalmia, Cornell University Steeds, Craig. Kansas University Stone, Eric, Marine Biological Laboratory Sweeney, Catherine, Marine Biological Laboratory

Takahashi, Hajime, Olympus Optical Co , Ltd., Japan Tanner, Geoffrey, Wesleyan University Terasaki. Mark, University of Connecticut Health Center Thompson, Reid, Dartmouth College Tokumaru, Hiroshi, Duke University Medical Center Tokumaru, Keiko, Duke University Medical Center Twig, Gilad, Technion, Israel Tzur, Yonatan, Hebrew University, Israel Emory University Vautrin, Jean, University of Montpellier, France Vetrano, Anna, Rutgers University Federal Department of Agriculture Villalba-Galea, Carlos, Duke University Medical Center Flower Garden Banks National Marine Sanctuary Vucinic, Dejan, Yale University Food and Drug Administration

Wachowiak, Matt, Yale University School of Medicine Gladstone Institute of Neurological Disease Weedon, Monica, Marine Biological Laboratory of Wetherington, Jonathan. Medical College Georgia Hartford, University of Weyand, Ingo, Institut fur Biologische Informationswerarbeitung, Harvard University Germany Harvard University Medical School Wheeler. N'sreha, Earlham College Hawaii, University of Williams, Keuuirsh. Howard University Howard University Wollert. Torsten. Universitat Rostock, Germany Hunter College

of United Yamasaki, Michiko. jnivc-rsity Oxford, Kingdom Illinois, University of Young, lain, University of Pennsylvania

Zakevicius, Jane, University of Illinois College of Medicine Zakon. Harold, University of Texas, Austin R39

Kansas. University of Foreign Institutions Represented

Louisiana State University of Loyola University Chicago Auckland, University of, New Zealand

of Maryland, University Barcelona, Universitat de, Spain of Massachusetts, University Buenos Aires, University of, Argentina Medical College of Georgia Miami School of Medicine, of University Cambridge, University of. United Kingdom Michigan State University Millersville University Edinburgh, University of, United Kingdom of Minnesota, University European Molecular Biology Laboratory, Germany

NASA Friedrich Miescher Institute, Switzerland National Institutes of Health National Institutes of Mental Health Hebrew University of Jerusalem, Israel New York State Institute for Basic Research Hong Kong University, Hong Kong New York University Hospital for Sick Children, Canada York School of Medicine New University Hull University, United Kingdom North Carolina State University North of Carolina, University Institut fur Biologische Informationswerarbeitung, Germany School Northwestern University Medical Institute of Protein Research, Russia Institute de Investigacion Medica "Mercedes y Martin Ferreyra, Ohio University Argentina Institute Venezolano Investigaciones Cientificas, Venezuela Penn State University of Pennsylvania, University Japan Biological Information Research Center, Japan Pomona College Providence College Kyoto University, Japan Puerto Rico, University of Max-Planck-lnstitute for Medical Research, Germany the State of New Rutgers, University Jersey McGill University, Canada Montpellier, University of, France Research Institute Scripps Munich, University of, Germany South Carolina, University of St of Mary's College Maryland Napoli "Federico II", Universita di, Italy Stanford University New Brunswick, University of, Canada State of New York Medical University University Upstate Nugata University, Japan Syracuse University Novartis International AG, Switzerland

Texas Health Science Center, University of Ltd . Olympus Optical Co , Japan Texas Southwestern Medical Center, of University Ottawa, University of, Canada of, Austin Texas, University Oxford, University of, United Kingdom Texas, University of, San Antonio Rockefeller The University Rio de Janeiro, University of, Brazil Roskilde University, Denmark Union College Rostock, Universitat, Germany Utah, University of Rudolf Magnus Institute for Neuroscience, The Netherlands

of Virginia, University Sao Paulo, University of, Brazil Technion-lsrael Institute of Technology, Israel Wadsworth Center Tokyo Medical and Dental University, Japan Wake Forest University School of Medicine Washington University Universidad Nacional de Mar del Plata, Argentina State School of Medicine Wayne University University of College London, United Kingdom Wesleyan University Utrecht, University of, The Netherlands Williams College Women and Infants Hospital Yokohama City University, Japan

Yale University Yale University School of Medicine R40

2002 FRIDAY EVENING LECTURES

June 21 Barry Bloom, Harvard School of Public Health "Economic and Political Implications of Global Infectious Diseases"

June 28 R. Alan B. Ezekowitz, Massachusetts Gen Hospital for Children "Fighting Infections from Flies to Man"

JulyS Lang Lecture Michael J. Ryan, University of Texas, AL "Sexual Selection and The Brain"

July 12 Gail K. Naughton, Advanced Tissue Sciences General Scientific Awards "Stem Cells and Tissue | Meetings Engineering: From Science Fiction to Medical Fact"

July 18, 19 On the recommenda- Senior Investigator: Forbes Lectures tion of the Science Peter Armstrong, Margaret Armstrong, R. L. Pardy, William Newsome, Stanford University Council, the MBL Alice Child, and Norman Wainwright, "Histochemi- I.Thursday, July 18 cal demonstration of lipopolysaccharide in the cell reinstated the MBL "Making Decisions: The Brain's Link Between wall of a eukaryote, the green alga Chlorella" Award for outstand- Perception and Action" at II. 19 ing presentations Junior Investigator: Friday, July Motion: the Laboratory's Michael Smotherman, "Acetylcholine mediates "Seeing Linking Neurophysiology to annual General excitatory input to chromatophore motoneurons in Perceptual Psychology" the squid, Loligo pealei" Scientific Meetings. July 26 The award in each Graduate Student: Michael Brown, University of Texas consists is category Beate Mittmann, "Early neurogenesis in the Southwestern Medical Center at Dallas a clock and horseshoe crab Limu/us and its crystal po/yphemus "Genetic Defenses Against Heart Attacks" for a $300 cash prize. implication arthropod relationships" August 2 Undergraduate Student: Fifty-six Steven Hyman, Harvard University presentations Jane La Du, Deana Erdner, Sonya Dyhrman, and were "Reflections on Behavior in given during Don Anderson, "Molecular approaches to under- the Era" the Meetings, which standing population dynamics of the toxic Postgenomic A/exandrium were held August 72 dinoflagellate fundyense" August 9 to 14 in the Lillie Student Honorable Mentions: Dan Barry, NASA Auditorium. After Jeremy M. Testa, Matt Charette, Edward Sholkovitz, "Sensations of Space Flight" of all peer-review Matt Allen, Adam Rago, and Craig Herbold, papers and talks, four "Dissolved iron cycling in the subterranean estuary August 16 awards and two of a coastal bay: Waquoit Bay, Massachusetts" Tim Hunt, Cancer Research UK, honorable mentions Clare Hall Laboratories D. E. Arnolds, 5. J. Zottoli, C. E. Adams, S. M. "What is the Cell and were p; -sented. Cycle Dineen, S. Fevrier, Y. Quo, and A. J. Pascal, How is it Controlled?" "Physiological effects of tricaine on the supramedullary/dorsal neurons of the cunner, Tautogo/abrus adspersus"

Nerve branches and synaptic endings in a musc/e of a transgenic mouse, Jeff Lichtman R41

Pub/ications

induced B Lanoil , A , Alliegro, M C 2002. Coiled body heterogeneity Cox, B. L., Popa, R., Bazylinski, D Douglas, arrest with amilonde + bumetanide. Cell Res. S A D L and Nealson, K.H 2002 by G1 Exp. , Belz, , Engler, and Fe-rich 279 111-117 Organization and elemental analysis of P-, S-, inclusions in a population of freshwater magnetococci. M A 2002 Nuclear injection Geomicrobio/. J. 19. 387-406 Alhegro, M C , and Alliegro endothelial cell division of anti-pigpen antibodies inhibits J Bio/. Chem. 277: 19,037-19,041 Crawford, Karen 2002 Culture method for in vitro fertilization to hatching of the squid, Loligo pealeit B T R L Pardy, Bio/. Bull- 203 216-217, Armstrong, Peter , Margaret Armstrong, Alice Child, and Norman Wainwright 2002 Immunohis- of a in the J T S and E L Bearer 2002. tochemical demonstration lipopolysacchande DeGiorgis, A , Reese, Biol Bull cell wall of a eukaryote, the green alga, Ch/orella Association of myosin II with axoplasmic organelles Mol. Biol Cell 13 203 203-204 implications for axonal transport 1046-1057 Arnolds, D E W.. S J Zottoli, C E Adams, S. M. Dineen, J Pascal 2002. H M Fishman 2002 S Fevrier, Y Guo, and A Physiological Eddleman, C S , G D Bittner. and neurons effects of tncaine on the supramedullary/dorsal SEM comparison of severed ends of giant axons isolated 203: of the cunner, Tautogolabrus adspersus Biol Bull from squid (Loligo pea/en) and crayfish (Procambarus 188-189 darkii) B.ol. Bull. 203: 219-220

2002 The role of R R. 2002 Directional E L P. P L . and Bearer, , and Satpute-Krishnan Edds-Walton, Fay viruses and mtracellular tau. the cytoskeleton in the life cycle of auditory processing by the oyster toadfish, Opsanus machines. bacteria tracks, motors, and polymerization Bioacoustics 1 2 202-204 Curr. Drug Targets Infect. Disord 2 247-264 P L L A and L C Rome Edds-Walton, , Mangiamele, Borst, Douglas, and Robert Barlow. 2002 Orcadian 2002 Variations of pulse repetition rate in boatwhistle horseshoe crabs. Bioacoustics rhythms in locomotor activity of juvenile sounds from oyster toadfish (Opsanus tau) Bio/. Bull. 203 227-228 13. 153-173

R S M J P and J P Xu 2002 R R 2002 The sense of in fishes. Bioacous- Boyle , Highstem, Carey, Fay, hearing Functional recovery of anterior semicircular canal afferents tics 12 167-169 3 149-166 following hair cell regeneration in birds JARO R R P L Edds-Walton 2002 Preliminary Fay. , and R E and G. M. interval of cells in the Brown, J , M Peacock-Villada, Langford evidence for interpulse selectivity 2002 Globular tail fragment of myosin-V displaces vesicle- torus semicircularis of the oyster toadfish (Opsanus tau). associated motor and blocks vesicle transport in squid Bio/. Bull. 203 195-196 nerve cell extracts Biol Bull 2 210-211 X J T L M Femandez-Busquets, , W Kuhns, Simpson, Cermak, Michael J 2002 Caranx /atus (Carangidae) Ho, D. Gerosa, M. Grab, and M M Burger 2002 Cell- schools a tactic to markers of chooses dock pilings to attack silverside adhesion-related proteins as specific sponge behavior of Bio/. in Dev. interfere with stereotyped escape prey? cell types involved allogeneic recognition Comp Bull. 203. 241-243. Immunol. 26: 313-323

R E R. Anton, and H 2002 S and M Hoffman 2002. Cl and Chappell, L., Schuette, Ripps Garber, Sarah , Mary rod-driven ERG b-wave of a anion GABAc receptors modulate the glutamate" competition for volume-regulated the skate retina Doc. Ophtha/mol 105: 179-188. channel Biol. Bull. 203 194-195

R Alan Kuzinan 2002 of axonal and B B 2002 Gene Clay, John , and Trafficking Giuditta, A., M Eyman, Kaplan Hsc70 J. Neurosci. Res. 67 axon neurotransmitter K+ channels potential role of expression in the squid giant 745-752 modulation of RNA transfer from penaxonal glia to the axon Bio/. Bull. 203 189-190 R Alvin Shner 2002 Clay, John , and Temperature of in axons with alkaline A B B J. van Mmnen, J Alvarez, and E dependence bistability squid giant Giuditta, , Kaplan, 213-223 mtracellular pH J Membr. Biol 187 Koenig 2002. Axonal and presynaptic protein synthesis of the neuron. Trends new insights into the biology

B L. M Yoshida, W I Lencer, Claypool S M , Dickinson, Neurosci. 25: 400-404 and R S Blumberg 2002 Functional reconstitution of human FcRn in Madm-Darby canine kidney cells requires J. Biol- Chem co-expressed human beta 2-microglobulin 277 28,038-28,050 Continued R42

Publications, continued

Golan. A., Y. Yudkovsky, and A. Hershko 2002 The cyclm- Ludlam, John P., David H. Shull, and Robert Buchsbaum 2002. Effects of ubiquitin ligase activity of the cyclosome/APC is jointly haying on salt-marsh surface invertebrates activated by protein kinases Cdkl-cyclin B and Plk. Bio/. Bull 203:250-251. J Biol. Chem. 277: 15,552-15,557. Ma. W.-L., and R R Fay 2002 Neural representations of Graf, Werner, Edwin Gilland, Matt McFarlane, Laura Knott, the axis of acoustic particle motion in the auditory midbrain and Robert Baker 2002 Central pathways mediating of the goldfish, Carassius auratus J. Comp. Physio/ 188: oculomotor reflexes in an elasmobranch, Scyltorhinus 301-313. canicu/a. Biol. Bull. 203: 236-238. Maddox, P., A. Desai, K. Oegema, T. J. Mitchison, and E B B M. T. P. D. Salmon. 2002. Poleward microtubule flux is a Hinkle, . Slepchenko, M Rolls, C. Walther, A major Stem, L M. Mehlmann, J Ellenberg, and M. Terasaki 2002 component of spindle dynamics and anaphase A in mitotic Chromosomal association of Ran during meiotic and mitotic Drosophi/a embryos. Curr. Biol 12: 1670-1674. divisions J. CellSd. 115: 4685-4693 R R and Megela-Simmons, A , Fay, A N Popper, eds. Huffaker, Diana, and R. Gil Pontius, Jr. 2002 Reconstruc- 2002 Springer Handbook of Auditory Research, Vol. 14, tion of historical land cover in the Ipswich Watershed Biol. Acoustic Communication. Springer-Verlag, New York. Bull. 203: 253-254

Mehlmann, L M , T L. 2. Jones, and L. A. Jaffe 2002.

Husted L. B., E. S. Sorensen, P. B. Armstrong, J. P. Quigley, Meiotic arrest in the mouse follicle maintained by a Gs L Kristensen, L Sottnjp-Jensen 2002. Localization of protein in the oocyte Science. 297: 1343-1345 carbohydrate attachment sites and disulfide bridges in A. and 2002. Umu/us a2-macroglobulin. Evidence for two forms differing Mensinger, F., M Deffenbaugh Acoustical primarily in their bait region sequences. J. Biol. Chem. 277: neural telemetry from free-swimming fish Bioacoustics 12: 43,698-43,706. 333-334.

A . R W. and C L. Rieder 2002 Islas-Flores, I., S. Corrales-Villamar, E L. Bearer, J C. Raya, Mikhailov, Cole, DNA and M.-A Villanueva 2002. Isolation of lipoxygenase damage during mitosis in human cells delays the isoforms from Glycine max embryo axes based on cross- metaphase/anaphase transition via the spindle assembly Curr. Biol. 12: 1797-1806. reactivity with anti-myosin antibodies Bioch/m. Biophys checkpont. Acta 1571: 64-70. Mittmann, Beatte 2002 Early neurogenesis in the Jimenez C J., M. Eyman, 2 Scotto Lavina, A. E. Gioio, K. horseshoe crab Limulus po/yphemus and its implication for P. Bio). Bull. 203: 221-222 W. Li. R van der Schors, W. M. Geraerts , A Giuditta, B arthropod relationships B. Kaplan, and J. van Minnen. 2002. Protein synthesis in

synaptosomes: a proteomics analysis. J. Neurochem. 81 : Montgomery, John, Guy Carton, and David Bodznick 2002. 735-744 Error-driven motor learning in fish. Biol. Bull. 203: 238-239.

T H. J R., G J and E M Lafer 2002 Kuner, , Tokumaru, and G J Augustine. 2002. Morgan, Augustine, Peptides as probes of protein-protein interactions involved Synaptic vesicle endocytosis: the races, places, and in molecular 2: neurotransmitter release Pp 552-570 in Peptide-lipid faces Neuromolecular Med 101-114. Interactions, S. A. Simon and T. J. Mclntosh, eds Academic Press, San Diego. Pahl, Nicholas, Sara Homsi, Hilary G Mornson, and Robert M Gould 2002 mRNAs located in Squalus acanthias Stained hippocamal La Du, Jane, Deana Erdner, Sonya Dyhrman, and Don (Spiny Dogfish) oligodendrocyte processes Bio'. Bu//. 203: pyramidal neuron fratj, Anderson 2002. Molecular to 217-218 Dan Johnston approaches understanding population dynamics of the toxic dinoflagellate A/exandrium fundyense Biol. Bull. 203: 244-245 Piccoli, G., M. Gomez, and E. Nasi 2002 Role of protein kmase C in light adaptation of molluscan microvillar Landowne, D. 2002. Perchlorate prevents sodium channel photoreceptors J. Physio/. 543 481-494. gating and sodium protects in the squid giant axon. Bio/. R F P. Bull. 203: 190-191. Rakowski, . D C Gadsby. and De Weer 2002. Single ion occupancy and steady-state gating of Na Langford, G. M. 2002. Myosin-V, a versatile motor for short- channels in squid giant axon. J. Gen. Physio/ 1 19: 235-249. range vesicle transport. Traffic 3: 859-865 Redenti, S., and R. L. Chappell. 2002. Zinc chelation

A. I. enhances the zebrafish retinal ERG b-wave Biol. Bull. 203: Lee, K-G , Braun, Chaikhoutdinov, J. DeNobile, M. Conrad, and W. Cohen. 2002. Rapid visualization of 200-202 microtubules in blood cells and other cell types in marine model organisms, Biol. Bull. 203: 204-206. R43

K. F and R B Barlow. Tirnauer J. S., S. E D Salmon, and T J Mitchison. Ridings, C , D Borst, Smith, Dodge, Grego, 2002. Visual behavior of juvenile Ltmulus in their natural 2002 EB1-microtubule interactions in Xenopus egg extracts: in stabilization and habitat and in captivity Bio/. Bull. 203 224-225. role of EB1 microtubule mechanisms of targeting to microtubules Mo/ Biol. Cell shock and the 13: 3614-3626. Rieder, C L , and R W Cole. 2002. Cold

mammalian cell cycle Cell Cycle 1 169-175 R P. K. P J S H. Twig, G , Malchow, Hammar, Smith,

H H J Zakevicius. 2002 Blockade of an and I. Perlman 2002 A novel turtle retinal Ripps, , Qian, and Levy, prepara- inward sodium current facilitates pharmacological study of tion for simultaneously measuring light-induced electrical Biol Bull 203: hemi-gap-junctional currents in Xenopus oocytes Biol. Bull. activity and changes in metabolite levels 203: 192-194 198-200

L B Zochowski. 2002 Ripps, H., H Qian, and J Zakevicius 2002 Pharmacologi- Wachowiak, M., Cohen, and M cal enhancement of hemi-gap-junctional currents in Distributed and concentration invariant spatial representa- Xenopus oocytes J Neurosci Methods 121: 81-92, tions of odorants by receptor neuron input to the turtle olfactory bulb J. Neurophysio/ 87 1035-1045 Ripps, H 2002 Cell death in retinitis pigmentosa gap Res 74 M R. R. A. Bass Directional junctions and the 'bystander' effect Exp Eye Weeg, , Fay, and 2002 327-336 response and frequency tuning in saccular nerve fibers of a vocal fish, Ponchthys notatus J Comp. Physio/. 188: Shuster, C B., and D R Burgess 2002 Targeted new 631-641. membrane addition in the cleavage furrow is a late, separate event in cytokinesis Proc. Nat/. Acad. So. USA. Weidner, Earl, and Ann Findley 2002 Peroxisomal catalase 99: 3633-3638 in extrusion apparatus posterior vacuole of microspondian spores. Biol. Bull 203 212 D. R 2002 Transitions Shuster, C B , and Burgess in cells. H V. A E and regulating the timing of cytokinesis embryonic Wen, , D Jurkovicova, M Pickel, Gioio, Curr.Biol. 12.854-858. B. B. Kaplan 2002 Identification of a novel membrane- associated protein expressed in neurons of the squid and Silver, Robert B., and Marc Bartman 2002 A metronome- rodent nervous system Ps/euroscience 1 14: 995-1004 like control of the calcium signal leading to nuclear envelope breakdown and mitosis in sand dollar White, T.W., M. Srinivas, H Ripps, A. Trovato-Salmaro, (Echinaracmus parma) cells Biol. Bull. 203 213-215 D. F. Condorelli, and R Bruzzone 2002 Virtual cloning, functional expression and gating analysis of human F A and R B Barlow 2002 connexin31 9 Am. J. Ce/( 283: C960- Smith, K , C. Ridings, Dodge, Physio/. Physiol. Development of the lateral eye of juvenile Limu/us Biol. C970 Bull. 203 222-223 WollertT., A. S DePina, R F Thompson, and G M 2 ' Smotherman, Michael 2002 Acetylcholme mediates Langford 2002 Ca effects on myosm-ll-mediated of excitatory input to chromatophore motoneurons in the contraction of pseudo-contractile rings and transport in of Biol. Bull 203 squid, Lo/igo pea/eii Bio). Bull. 203 231-232 vesicles extracts clam oocytes 206-208 M.E. and S 2002 Sommers, M.G , Dollhopf, Douglas, Freshwater ferromanganese stromatolites from Lake WollertT, A S DePina, R F Thompson, and G M Vermilion, Minnesota microbial culturing and environmen- Langford. 2002 GTPase Rho is involved in myosin-ll- tal scanning electron microscopy investigations mediated contraction of pseudo-contractile rings and Geomicrobio/. J. 19: 407-427 transport of vesicles in extracts of clam oocytes Biol Bull. 203 208-210 R F M 2002 Thompson , and G Langford Myosin superfamily evolutionary history Anat Rec 268 276-289

J Julie C. E D and J Tirnauer, , Canman, Salmon, Timothy Mitchison 2002 EB1 targets to kinetochores with attached, polymerizing microtubules Mo/ Biol. Cell 13 4308-4316 R44

education

The 2002 Education Program provided 499 students from 288 institutions and 30 countries an opportunity to study a range of biological topics with some of the best and brightest scientists in the world serving as course faculty and lecturers. The Laboratory welcomed 554 faculty members and staff and 203 lecturers to the courses in 2002. They represented 175 institutions and 31 countries. Among the many outstanding lecturers last summer, we were especially pleased to host two Nobel Laureates, Michael Brown and Tim Hunt, who gave the Arthur K.

Parpart and the Irvin Isenberg Lectures, respectively, in the Physiology course.

In addition to the MBL's six major summer courses, we offered 14 special topics courses

throughout the year, including two exciting new courses: Advances in Genome Technology and Bioinformatics, directed by Claire M. Fraser, TIGR, and Mitchell Sogin, MBL; and Neuroinformatics, directed by Partha Mitra of Lucent Technologies, Emery Brown of Massachu-

setts General Hospital, and David Kleinfeld of the University of California, San Diego.

At the end of the 2002 season, we bid farewell to Chris Tschudi and Elisabetta Ullu, directors of

the Biology of Parasitism course. Jay Bangs of the University of Wisconsin, Madison, will take the helm of that course in 2003. We also said goodbye to Bill Bialek and Rob de Ruyter Van Steveninck of the Computational Neuroscience course. Bard Ermentrout of the University of Pittsburgh and John White of Boston University will assume the directorship of the course in 2003. In addition, Sandra Masur, of Mount Sinai School of Medicine, joined David Papermaster as co-director of the Vision Research course in 2002.

The MBL's educational program once again received a stamp of approval from the National Institutes of Health's competitive peer review process with renewed funding for the Embryol- ogy, Neural Systems & Behavior, and Neurobiology courses, and new funding for the inaugural Neuroinformatics course. R45

SUMMER COURSES

Biology of Parasitism: Modern Approaches June 13- August 10, 2002 Martmdale. Mark, University of Hawaii Niswander, Lee, Sloan-Kettermg Institute DIRECTORS Patel, Nipam, University of Chicago Tschudi, Christian, Yale University Medical School Saunders, John, Retired Institute of Ullu, Elisabetta, Yale University Medical School Sherwood, David, California Technology FACULTY Zeller, Robert, San Diego State University Bangs. James, University of Wisconsin-Madison Grencis, Richard, University of Manchester LECTURERS of Hajduk, Stephen. University of Alabama- Davidson, Eric. California Institute Technology Birmingham Keller, Ray, University of Virginia Matthews. Keith, University of Manchester Greenwald. Iva, Columbia University McFadden, Geoff, University of Melbourne Joyner, Alexandra, New York Umversity/HHMI Seattle Biomedical Research McGmnis. William, of California. Parsons. Marilyn. Kevin Begos University Institute San Diego Harvard Rathod, Pradip, University of Washington COURSE ASSISTANTS Robertson, Elizabeth, University Reiner. Steven, University of Pennsylvania Bridegam, Patrick, Texas A&M University Sanes, Joshua, Washington University at Austin McKmnon, Nicole. University of Victoria. 8-C Shankland, Martin. University of Texas Tarleton. Rick. University of Georgia Struhl. Gary. Columbia University STUDENTS Tramor. Paul, Stowers Institute for Medical

LECTURERS Avila, Andrea, Inst de Biol Molecular do Research Allen, Judith, University of Edinburgh Parana-IBMP Wieschaus. Eric, Princeton University Cross, George, Rockefeller University Chamond, Nathalie, Institut Pasteur Wray, Gregory, Duke University York School Deitsch. Kirk, Weill Medical College of Cockburn, Ian, University of Edinburgh Yelon, Deborah, New University Cornell University Fenn, Katelyn, University of Edinburgh of Medicine Johns Medical School York Englund, Paul, Hopkins Green, Heather , New University Garside, Paul, University of Glasgow Karnataki, Anuradha, University of Washington S MERYL ROSE LECTURER of Hunter, Christopher, University of Pennsylvania Klotz, Christian, Humboldt-University-Berlin Gerhart, John, University California. Berkeley Muller. Miklos. The Rockefeller University KOOIJ, Taco, Leiden University Medical Centre Nutman, Thomas. National Institutes of Health Lee, SooHee. Johns Hopkins School of Medicine TEACHING ASSISTANTS Seattle Biomedical Research Baker. Clare. of Panigrahi, Aswini, Li, Hongiie, Yale University University Cambridge of North Carolina- Institute Meissner, Markus. Imperial College of Science, Cheeks, Rebecca, University Pearlman, Eric. Case Western Reserve University Technology & Medicine, UK Chapel Hill Center Institution of Phillips. Meg, UT Southwestern Medical Mueller, Ann-Kristin. University School of Gamse, Joshua, Carnegie Riley. Eleanor, London School of Hygiene & Medicine, Heidelberg Washington Matthias, of Tropical Medicine Nkmin, Wuyika, University of Yaounde Gerberdmg, University Chicago Rudenko, Gloria. University of Oxford Slavin, lleana, Universidad Nacional de Cordoba Gross, Jeffrey. Duke University of Sacks. David. NIAID, NIH Stubbs. Janine, Royal Melbourne Hospital Khokha. Mustafa, University California, Scherf, Artur, Institut Pasteur Berkeley/MCB of Stanley. Sam, Washington University Kuhlman, Julie, University Oregon Centre Moleculaire Striepen. Bons, University of Georgia Lartillot. Nicolas, Genetique The Liu. Karen. of California, Waters, Andrew. Leiden University. Embryology: Concepts and University Berkeley Netherlands Maduro, Morris, University of California, in Modern White. Michael, Montana State University Techniques Santa Barbara of Hawaii/PBRC Wilson, lain. National Institute for Medical Developmental Biology Nederbragt, Alexander, Unversity Research June 16 -July 28, 2002 Solomon, Keely, Emory University Wynn, Thomas. National Institutes of Health Tobey. Allison, Memorial Sloan Kettenng Dobbelaere. Dirk, University of Bern DIRECTORS Cancer Center of California, Roditi, Isabel, University of Bern Richard Harland, University of California. Berkeley Wallmgford, John, University Soldati, Dominique, Imperial College of Science Joel Rothman, University of California, Berkeley for Biomedical & Technology Santa Barbara Walsh, Emily. Whitehead Institute Research TEACHING ASSISTANTS FACULTY Weatherbee. Scott. Memorial Sloan Kettenng Cancer Center Jiang, Lei, University of Washington Fraser, Scon, California Institute of Technology Whitehead Institute for Karthikeyan, Ganesan, University of Washington Levine, Michael. University of California. Berkeley Wiellette, Elizabeth, Biomedical Research Mollard, Vanessa, University of Melbourne Rokhsar, Dan. University of California. Berkeley for Research Artis, David, University of Pennsylvania Tabm. Clifford, Harvard University Wilson. Valene. Centre Genome of Illinois. Urbana Cummings, Kara. University of Georgia Blair, Seth, University of Wisconsin-Madison Wolfe. Adam. University Jensen, Bryan, Seattle Biomedical Research Bronner-Fraser. Marianne. California Institute ASSISTANTS Institute of Technology COURSE Mair, Gunnar, Queen's University Belfast Collazo. Andres. House Ear Institute Balligan, Sarah, University of Missouri-Columbia Marine Martin, Diana, University of Georgia Ettensohn, Charles, Carnegie Mellon University McCluskey. Kathryn, Biological Pennock, Joanne, University of Manchester Halpern, Marnie, Carnegie Institution of Laboratory of Ralph, Stuart, University of Melbourne Washington Tai, Phillip, University California, Berkeley Wisconsin-Madison Illinois Triggs, Veronica, University of Henry, Jonathan, University of van Deursen, Fredenck, The University Krumlauf, Robb, Stowers Institute for Medical of Manchester Research Continued. R46

STUDENTS

Berry, Katy, University of Sheffield Brown, Ann, Medgar Evers College Caracino, Diana, Emory University School of Medicine

Copf, Tijana, University of Crete Crotwell, Patricia, University of South Dakota Dash, Satya, University of East Anglia Delalande, Jean-Marie, University College London Drago, Grazia, Universita Degli Studi di Palermo Extavour, Cassandra, University of Cambridge Guest, Jennifer, National Institute for Medical Research Kee, Yun, California Institute of Technology Kerney, Ryan, Harvard University Koziel, Lydia, Max-Planctc-lnst. for Molecular Genetics

Livi, Carolina, University of Texas Health Science Center, San Antonio Malartre, Marianne, University of Portsmouth Maslakova, Svetlana, Smithsonian Institution Kevin Matus, David, University of Hawaii Begos Mitchell, Tracy, University of Wisconsin-Madison Muyskens, Jonathan, University of Oregon TEACHING ASSISTANTS Neural Systems & Behavior Nouri, Ali, Princeton University - Behrens, Sebastian, MPI for Marine Microbiology June 16 August 10, 2002 Orsborn, University of Missouri-Columbia Apnl, Martiny, Adam, Danmark Tekniske Universitet Primus, Alexander, University of Texas, Austin Mueller, Jochen, Stanford University DIRECTORS Roche, Daniel, University of California, Berkeley Schaefer, Amy, University of Iowa Carr, Catherine, University of Maryland Su, Yi-Hsien, Inst. of Scripps Oceanography, Levine, Richard, University of Arizona MBRD COURSE COORDINATOR Van Stry, Melante, Boston University School of Hawkins, Andrew, University of Iowa FACULTY Medicine Baines, Richard, University of Warwick LAB ASSISTANT Calabrese, Ronald. Emory University Waterbury, Matthew, Marine Biological Laboratory Chitwood, Raymond, Baylor College of Medicine Davis, Graeme, University of California, Microbial Diversity STUDENTS San Francisco June 16- August 2, 2002 Boucher, Yan, Dalhousie University French, Kathleen, University of California, San Diego Case, Rebecca, University of New South Wales Glanzman, David, University of California, DIRECTORS Clement, Barbara, Doane College Los Angeles Harwood, Caroline, University of Iowa Denef, Vincent, Michigan State University Golowasch, Jorge, Rutgers University Spormann, Alfred, Stanford University Dethlefsen, Les, Michigan State University Kristan, William, University of California, San Diego Dick, Gregory, Scripps Institute of Mooney, Richard, Duke University FACULTY Oceanography Nadim, Farzan, Rutgers University Buckley, Daniel, University of Connecticut Erbs, Marianne, Swiss Fed. Inst. for Philpot, Ben, Brown University of Gibson. Jane. Cornell University (Emerita) Environmental Science & Technology Pnjsky, Glen, University Lethbridge Marsh, Terence, Michigan State University Gentile, Margaret, Stanford University Reyes, Alex, New York University Ginder-Vogel, Matthew, Stanford University Ribera, Angeles, University of Colorado Health LECTURERS Graco, Michelle, University of Pierre et Marie Sciences Center Boetius, Antje, MPI fur Marine Mikrobiologie Curie Roberts, William, University of Oregon Breznak, John, Michigan State University Harrison, Faith, University of Iowa Simon, Jonathan, University of Maryland Delong, Edward, Monterey Bay Aquarium Koren, Omry, Tel Aviv University Stein, Wolfgang, Universitaet Ulm Aires Elhai, Jeff, Virginia Commonwealth University Lostroh, Phoebe, University of Iowa College Szczupak, Lidia, Universidad de Buenos of Giovannoni, Stephen, Oregon State University of Medicine Weeks. Jams, University Oregon Gottschalk, Gerhard, Institut fur Mikrobiologie Maresca, Julia, Pennsylvania State University Wenning-Erxleben. Angela, Emory University u Genet Pinel, Nicolas, University of Washington Wessel, Ralf, Washington University Handelsman, Jo, University of Wisconsin Rajagopal, Soumitra, University of Nebraska Wilson, Richard. University of Calgary Larimer, Frank, Oak Ridge National Laboratory Remold, Susanna, Michigan State University Wood, Debra, Case Western Reserve University Lory. Stephen, Harvard Medical School Sharp, Katherine, Scripps Institute of Wood, Emma, University of Edinburgh Loveley, Derek, University of Massachusetts Oceanography Zhang, Bing, University of Texas at Austin Meeks, John, University of California Spain, Jim, United States Air Force

' Metcalf. Wii:.. '-.vr'sity of Illinois Walker, Jeffrey. University of Colorado LECTURERS Rocap, Gabnelle, University of Washington Augustine, George, Duke Medical Center

:>f of Strous. Marc, b rsil , Nymegen Bate. Michael, University Cambridge Thauer, Rudolf, MHI fur Terrestr. Mikro Feldman, Daniel, University of California, San Diego Wackett, Lawrence, University of Minnesota Finger, Thomas. University of Colorado Health Wolfe. Ralph, University of Illinois Sciences Center R47

Neurobiology TEACHING ASSISTANTS June 16- August 17. 2002 Allana, Tariq. Boston University Chang, Paul, New York University DIRECTORS Godinho, Leanne, Washington University School Faber. Donald, Albert Einstein College of of Medicine Medicine Guan, Zhuo, Massachusetts Institute of Lichtman, Jeff, Washington University School Technology School of Medicine Misgeld, Thomas, Washington University of Medicine SECTION DIRECTOR Rosenberg, Madelaine, Tufts University DeFranco, Donald. University of Pittsburgh Szabo, Theresa. Albert Einstein College School of Medicine of Medicine

Stewart, Bryan, University of Toronto FACULTY COURSE ASSISTANTS Science Marine Trussell, Larry. Oregon Health & University Buchanan, JoAnn, Stanford University Hall. David. Biological Laboratory Los Texas A & M White, Stephanie, University of California, Conchello. Jose-Angel, Washington University Satterlee, Danielle, University Angeles Medical School Coyle, Joseph, Harvard University STUDENTS TEACHING ASSISTANTS Denk, Winfried, MPI fur Medical Research Boassa, Daniela, University of Anzona College Beenhakker, Mark, University of Pennsylvania Gan, Wenbiao, New York University of Medicine of Bradford, Yvonne, University of Oregon Hart, Anne, Massachusetts General Hospital Campbell, Susan, University Alabama, Chen, Shanping, House Ear Institute Heuser, John, Washington University Birmingham Harbor Coleman, Melissa, Duke University Jacob, Michele, Tufts University Ewald, Rebecca, Cold Spring Laboratory of California, Los Einstein of Colorado Ezzeddine, Youssef, University Kaprielian. Zaven. Albert College Hobbs, Steven, University Angeles of Medicine Hu, Hailan, University of California, Berkeley of Fairies, Michael, University of Pennsylvania Khodakhah, Kamran, Albert Einstein College Ihring. Alexandra, Max-Planck-Institute Heiser, Ryan, University of Colorado Health of Medicine Neurobiology Sciences Lambert, Nevin, Medical College of Georgia Koirala, Samir, University of Southern California Labs/Lucent MacLeod, Katnna, University of Maryland, Levinthal, David, University of Pittsburgh Kozhevnikov, Alexay. Bell College Park Lin, Jen-Wei, Boston University Technologies Massachusetts Institute of Miller, Julie. University of Arizona Littleton, J. Troy, Massachusetts Institute Montana, Enrico, Roberts, Adam. University of California, of Technology Technology International School for Los Angeles Logothetis. Nikos, MPI for Biological Cybernetics Petersen, Rasmus, Roy. Arani, Duke University McMahon, Lori, University of Alabama Advanced Study (SISSA) State School of Health Siegel, Jennifer, Bowling Green University Pimenta, Aurea, University of Pittsburgh Ryan, Amy, University Virginia Systems Medical School Scares, Daphne, University of Maryland of Medicine Zhou. Zhaolan (Joe), Harvard Svoboda. Kurt, University of Colorado Health Preuss, Thomas, Albert Einstein College of Sciences Center Medicine Villareal, Greg, University of California. Price, Donald, Johns Hopkins Universtiy Los Angeles Reese, Tom, NIH Physiology: The Biochemical M of of California. Zee. Jade. University Oregon Schweizer, Felix, University and Molecular Basis of Cell Los Angeles COURSE ASSISTANTS Smith, Stephen, Stanford University Signaling 2002 Cardon, Aaron, Texas A & M University Thompson. Wesley, University of Texas June 16- July 27, Rodrigues, Elizabeth, University of Oregon Wong, Rachel, Washington University Shaw, Abigail, Stanford University DIRECTORS LECTURERS Garbers, David, UT Southwestern Medical STUDENTS Aimers. Wolfhard, Vollum Institute Center/HHMI Chang, Andrew, Oregon State University Auerbach, Anthony, SUNY at Buffalo Reed, Randall, Johns Hopkins University/HHMI De Labra. Carmen, University College London Bear, Mark, HHMI/Brown University Dellen. Babette, Washington University, St. Louis Brodin, Lennart. Karolinska Institute! FACULTY Ottawa Cancer Research Fund Doiron, Brent, University of Chapman, Ed, University of Wisconsin-Madison Duncan, Tod, Imperial Dulcis, Davide, University of Arizona. Tucson Harlow, Mark, Stanford University Ehrlich, Barbara, Yale University of of Minnesota Higley, Michael. University Pennsylvania Harris, Ken Rutgers University Franco, Peter, University of Davis Hughes, Cynthia, Indiana University Hoh. Jan, Johns Hopkins School of Medicine Furlow, David. University California, of Arizona of of Texas Julian, Glennis, University Hopkins, Nancy, Massachusetts Institute Kao, Ling-Rong, University Medical Center Khalil, Mona. Columbia University Technology Southwestern Austin of California, Davis Miranda, Jason, University of Texas at Huguenard, John, Stanford University Lim, Wayland. University of Texas Pfeiffer, Keram, Philipps-Umversitat Marburg Kernan, Maurice, SUNY at Stony Brook Megraw, Timothy, University Southwestern Medical Center Renart, Alfonso, Brandeis University Lipscombe, Diane, Brown University of State Health Schultz, Nikolaus, of Texas Rutherford. Mark, University Oregon Magee, Jeffrey, Louisiana University University Center Sebe, Joy. University of Washington Science Center Southwestern Medical State Spitzer, Nadja, Georgia University McMahan, Del J , Stanford University of Texas Institute of LECTURERS Steinberg, Rebecca, University Nedivi, Elly, Massachusetts Medical School Sternson, Scott, Rockefeller University Technology Bennett, Anton, Yale Harvard Medical School Witney. Alice. University of Birmingham Nicolelis, Miguel, Duke University Clapham, David, of Texas Medical School Ogden, David, National Institute for Medical Comerford, Sarah, University Wohlgemuth, Sandra, Humboldt-Universitat Research Southwestern Medical Center Johns zu Berlin Ryan, Tim, Weill Medical Cornell Devreotes. Peter. Hopkins University School of Medicine Zomik, Erik, Columbia University Sigworth, Fred, Yale University Harvard Medical School Svoboda. Karel. Cold Spring Harbor Laboratory Dietnch, William, San of Texas Southwestern Tsien, Roger. University of California. Diego Gardner, Kevin. University Medical Center Tim, Cold Spring Harbor Laboratory Vestibular spinal neurons in the goldfish brain, Tully. Harvard Medical School Continued Steven Zottoli Yellen, Gary, R48

2002 SPECIAL LECTURE SERIES

Meryl S. Rose Lecture (June 17) John Gerhart, University of California, Berkeley "Cells. Embryos, and Evolution. Toward a Cellular and Developmental Understanding of Phenotypic Variation and Evolutionary Adaptability" R< of Texas Hammer, , South --cdical Center /rv;n /senberg Lecture (June 21) Nobel International Cancer Research Clare Hall Lab Hepler "rsity of Massachusetts Timothy Hunt, Laureate, Fund, of "Protein and the Control of the Cell Mang*: 3 .J^vid, University Texas Synthesis Cycle" Southwestern Medical Center Nambu, John, University of Massachusetts Gertrude Forfcosh Waxier Lecture (July 1 7) Stock, Ann, University of Medicine & Dentistry, Robert A. Weinberg, Massachusetts Institute of Technology New Jersey-RW Johnson Medical School/HHMI "Rules for Making Human Tumor Cells" Tilney, Lewis, University of Pennsylvania Welsh, Michael, University of Iowa Teru Ha/ashi Lecture (July 23) Melanie H. Cobb, University of Texas Southwestern Medical Center IRVIN ISEN8ERG LECTURER "Information Flow in MAP Kinase Cascades" Hunt, Timothy, International Cancer Research Fund, Clare Hall Laboratories Arthur K. Parpart Lecture (July 26) Michael Brown, Nobel Laureate, University of Texas Southwestern Medical Cente GERTRUDE FORKOSH WAXLER LECTURER "The SREBP Pathway: How the Membrane Tells the Nucleus What it Needs" Weinberg, Robert, Whitehead Institute Ruth Sager Lecture in Genetr'cs (August 30) ARTHUR K. PARPART LECTURER Mark Fishman, Massachusetts Hospital and Harvard Medical School Brown, Michael, University of Texas "Genetic Modules: Fashioning Organs in Zebrafish" Southwestern Medical Center

TERU HAYASHI LECTURER SPECIAL TOPICS COURSES

Cobb, Melanie, University of Texas Southwestern Medical Center Advances in Genome Technology Palmer, Jeffrey, Indiana University TEACHING ASSISTANTS & Bioinformatics Pearson, William, University of Virginia Yale The Institute for Genomic Research Anyatonwu, Georgia, University October 6 - November 2, 2002 Peterson, Scott, Rengifo, Juliana, Yale University Pop, Mihai, The Institute for Genomic Research DIRECTORS Quackenbush. John, The Institute for Genomic Research COURSE COORDINATOR Fraser, Claire, The Institute for Genomic Research Kristen. of Texas Southwestern Reich, Claudia, of Illinois Rossi, University Sogin, Mitchell, Marine Biological Laboratory University Medical Center Reysenbach, Anna-Louise, Portland State University FACULTY Ringwald, Martin, Jackson Laboratory COURSE ASSISTANTS of Bateman, Alex, Sanger Institue Roos, David, University Pennsylvania Dana, of Texas Southwestern The Institute for Genomic Research Grellhesl, University Blake, Judith, Jackson Laboratory Salzberg, Steven, Medical Center Smith, Hamilton, Celera Genomics Churchill, Gary, Jackson Laboratory Sara-Love, of Texas Tettelin, Herve, The Institute for Genomic Research Swaney, University Cummings, Michael, Marine Biological Laboratory Southwestern Medical Center Venter, The Institute for Genomic Research deJong, Pieter, Children's Hospital Oakland Craig, Research Institute Wernegreen, Jennifer, Marine Biological Laboratory STUDENTS The Institute for Genomic Research DeLong, Edward, Monterey Bay Aquarium White, Owen, Institute Politecnico Aguilar, Arturo, National, Eisen, Jonathan, The Institute for Genomic Mexico Research TEACHING ASSISTANTS of Notre Dame The Institute for Genomic Research Amarie, Dragos, University Eisen, Michael. Lawrence Berkeley Tallon, Luke, National The Institute for Genomic Research Chen, Yen-Chin, Cheng Kung University Feldblyum, Tamara, The Institute for Genomic Radune, Diana, Medical College Research Vamathevan, Jessica, The Institute for Genomic Curtis, Johns School of Medicine Research Chong, Hopkins Felsenstein, Joe, University of Washington Davis, Kevin, of The Institute for Genomic Research University Pittsburgh Florens, Laurence. Scripps Research Institute Davidsen, Tanja, Arizona State The Institute for Genomic Research Dojcinovic, Danijel, University Gill, Steven, The Institute for Genomic Research Gill, John, Bedrick, Harvard Medical School Nirmal, The Institute for Genomic Research Gadea, Gray, Michael, Dalhousie Institute Bhagabati, of Riverside Alexander, The Institute for Genomic Research Ge, Lan, University California, Heidelberg, John, The Institute for Genomic Saeed, Goentoro, Lea, Princeton University Research White, Joseph, The Institute for Genomic Research Beth Israel The Institute for Genomic Kaynar, Murat, Deaconess Jaffe, David, Whitehead Institute for Biomedical Thiagarajan, Mathangi, Medical Center Research Research Melissa, of The Institute for Genomic Research Kelly, University Kentucky College Kent, Jim, University of California, Santa Cnjz Wang, Hong-Ying, of Medicine The Institute for Genomic Research Kim, Ulandt, Marine Biological Laboratory Gaspard, Renee, of The Institute for Research Kydd, Alison, University Calgary Lee, Norman, The Institute for Genomic Research Frank, Bryan, Genomic LaPointe, Nichole, Northwestern The Institute for Genomic Research University Mann, Barbara, University of Virginia Health Hasseman, Jeremy, of McVaugh, Cheryl, University Pennsylvania System Oh, Ji-Eun, of Illinois at STUDENTS University Chicago McArthur, Andrew, Marine Biological Laboratory Pace, of Texas Brad, NASA Ames Research Center Margaret, University Mesirov, Jill, Whitehead Institute for Biomedical Bebout, Pignatelli, Vincenzo, University of Pisa Research Brodhagen, Marion, Oregon State University Pineda, Gabn'el, of Texas of Georgia University Morrison, Hilary, Marine Biological Laboratory Bundy, Becky, University Southwestern Medical Center Chen, Lishan, of Myers, Eugene, Celera Genomics University Washington Children's Boston Centers for Disease Control Ramos, Arnolt, Hospital, Nelson, Karen, The Institute for Genomic da Silva, Alexandre, Rossi, Chiara, University of Pisa Research and Prevention Indiana Medical Center of Utah Sha, Edward, University Nierman, William, The Institute for Genomic Doak, Thomas, University Thamatrakoln, Kimberlee, University of California, Research Duvefelt, Kristina, Karolinska Institute! San Diego Nusbaum, Chad, Whitehead Institute for Fenwick, Brad. Kansas State University Vega, Rebecca, Stanford University Biomedical Research Francis, Susan, University of Washington of William & Ochman, Howard, University of Arizona Gilchrist, George, College Mary Golden, Daniel, of Alabama, Birmingham Olsen, Gary, University of Illinois University R49

John, Yale School Molecular of Handley, Heather. Woods Hole Oceanographic Fitzpatrick, University Biology Aging Medicine - Institution of August 5 August 24, 2002 Hildebrandt, John. Medical University of South Fleming, Shawna, Brown University Carolina Fu, Lianwu, University of Alabama, Birminghan DIRECTORS Stanford School Institute of Kanzok, Stefan, Yale University School of Medicine Galko, Michael, University Guarente, Lenny, Massachusetts of Medicine Kiesling, Traci, University of Miami Technology Health and Sciences of Irvine Kimbell. Jennifer, University of Hawaii Glover, Greta. Oregon Wallace. Douglas, University California, Kinnersley, Margie, University of Montana University Neumann, Tobias, Carl Zeiss Green, Heather, New York University FACULTY Jena-Pineda, Fernando, Johns Hopkins Gruenbaum. Lore, Boehringer Ingelheim Culotta, Valeria, Johns Hopkins University Bloomberg School of Public Health Pharmaceuticals Kirkwood, Tom, University of Manchester Habdas, Piotr, Radniecki, Tyler, Yale University Emory University Lambeth, Dave, Emory University of Ranson, Hilary. Liverpool School Tropical Medicine Sawyer, Sara, Cornell University Thomas, Bolaji, Tufts University Williams, David, Illinois State University

Analytical and Quantitative Light Microscopy May 9- May 17, 2002

DIRECTORS Sluder, Greenfield, University of Massachusetts Medical Center Wolf, David, BioHybrid Technologies

FACULTY Amos, William, MRC Lab of Molecular Biology Bulseco, Dylan, University of Massachusetts Medical School Cardullo. Richard. University of California Gelles, Jeff, Brandeis University Hinchcliffe, Edward, University of Notre Dame Inoue, Shinya, Marine Biological Laboratory Moomaw, Butch, Hamamatsu Photonic Systems Reichelt, Stefanie, MRC Lab of Molecular Biology Salmon, Edward, University of North Carolina, Chapel Hill Silver, Randi, Weill Medical College Cornell Drosophila, April Orsborn University Spring, Kenneth, National Institutes of Health Jason, of Dundee Swedlow, University Hidalgo, Carlos, Institute Venezolano de Weindruch, Richard, University of Wisconsin Waters Shuler, Jennifer, Harvard Medical School Investig- Cientificas Bishop, Nicholas, Massachusetts Institute Sensor Sears, Kathryn, Technologies Iszard, Melissa, Raytheon Polar Services of Technology Jungnickel, Melissa, University of Massachusetts Helfand, Stephen, University of Connecticut LECTURERS Medical School Health Center Aaron, Harvard Medical School Center Straight, Liu, Songtao. Fox Chase Cancer Price, Donald, Johns Hopkins University Mel, Smithsonian Institution Wachowiak, Luna, Elizabeth, University of Massachusetts Ruvkun, Gary, Massachusetts General Hospital Medical School Wright, Woodring, University of Texas ASSISTANT TEACHING McKeown, Caroline, University of Utah Southwestern Medical Center of Massachusetts Ehrhardt. Anka, University Paladino, Simona. University of Naples Medical School Panetti, Tracee, Temple University School of LECTURERS Medicine Pelicci. Pier Giuseppe, European Institute of COURSE ASSISTANT San Poskanzer, Kira, University of California. Oncology Joshua, of Massachusetts Nordberg, University Francisco Austad, Steven, University of Idaho Medical School Powers, Maureen, Emory University Bohr, Vilhelm, National Institute on Aging, NIH Raphael, Marc, The Naval Research Laboratory Campisi, Judith, Lawrence Berkeley National STUDENTS Rusan. Nasser, University of Massachusetts, Laboratory Samit, Weill Medical of Chatterjee, College Amherst Davenport, John, AAAS Cornell University of Massachusetts, of Smyth. Jeremy, University Donehower, Larry, Baylor College Medicine Emma-Louise, AstraZeneca R&D, Cooke, Amherst Goldberg, Alfred, Harvard Medical School Charnwood. UK Tarn, Jenny, Tufts University Hanawalt, Philip, Stanford University Counterman, Anne, Pennsylvania State Inc. Wagener, Michael. Carl Zeiss, Harley, Calvin, Geron Corporation Medical Center University Welch, Jeffrey, Duke University Hekimi, Siegfried, McGill University Ricardo, of Espinosa Tanguma, University Yamamoto, Akihiro. RIKEN, Japan Jones, Dean. Emory University San Lui Potosi Zandbank-Zuker, Keren, Hebrew Universtiy Kim, Stuart, Stanford University Fischer, Robert, The Research Institute of Scnpps Zhang. LingLi, University Pennsylvania Martin, George. University of Washington

Continued... R50

Ducibella, Thomas, New England Medical Center COURSE COORDINATOR Partridge, Linda, University College London Hunt, Joan, University of Kansas Roberts, Sheila. Bridgewater State College Richardson, Arlan, University of Texas Health of Connecticut Science Center at San Antonio Jaffe, Launnda, University Health Center COURSE ASSISTANT Tatar, Marc, Brown Unive'j'ty Northwestern Harrison, State Tower, John, Universe ?'n California Mayo. Kelly. University Emily, Bridgewater College Moore, Karen, University of Florida Tufts School STUDENTS TEACHING ASSIST, Overstrom, Eric, University of Veterinary Medicine Akcali, Kamil, Bilkent University, Turkey Coskun, Elif Pi ;ry University Schatten, Gerald, of Bachman, Katherine, Case Western Reserve Kaeberlein. ' jchusetts Institute of University Pittsburgh of Technology Shupnik, Margaret, University Virginia University Medical Center Busso, Dolores, Buenos Aires University Kerstani-,. Keilh, Emory University Terasaki, Mark, of Connecticut Gill, of Kansas Medical Center Kokoszka, Jason, Emory University University Ryan, University Health Center Joanna, of California, Visithawan. Mo, Massachusetts Institute Gonsalves, University of Medicine San Francisco of Technology Weigel, Nancy, Baylor College Hallikas, Outi, University of Helsinki Liszt, Gregory, Massachusetts Institute of Lecturers Ka, of Kansas Medical Center Technology Hakhyun, University Gosden, Eastern Medical School Umit, Yale University School of Medicine Subramaniam, Vaidya, Emory University Roger, Virginia Kayisli, Guillette, Louis, University of Florida Kreeger, Pamela, Northwestern University Western Reserve of COURSE COORDINATOR Hassold, Terry, Case University Perez. Christian, University Pennsylvania Miele, Lucio, of Illinois at Chicago Prosen, University of Pittsburgh Burke, Rhonda, Emory University University Tracy, Nilson, John, Case Western Reserve University Sachdeva, Geetanjali, Institute for Research COURSE ASSISTANT Ober, Carole, University of Chicago in Reproduction Richards, JoAnne. Baylor College of Medicine Torrens. Javier, New Jersey Medical School, Wylie, Michael, University of Michigan Sarras Jr, Michael, University of Kansas UMDNJ STUDENTS Medical Center Tou, Janet. NASA Ames Research Center of Northwestern Medical School Almeida, Claudia, Weill Medical College Schultz. Richard, University Pennsylvania Wang, Eileen, Seminara, Massachusetts General of Cornell University Stephanie, Bishop, Glenda, Case Western Reserve University Hospital Shenker, Andrew, Northwestern University Bokov, Alex. University of Texas Health Science Medical School Center, San Antonio Fundamental Issues in Vision Calvin, Pittsburgh Development Center Chen, Lishan, University of Washington Simerly, Research of Suarez-Quian, Carlos, Georgetown University Dunaief, Joshua, University Pennsylvania - 1 1 24, 2002 Medical School August August Fuller, Kattiryn, University of Minnesota Tasca, Richard, NIH Harvey, Sarah, Medical College of Virginia Wells, St Barnabas Medical Center Hong, Eun-Jm (Erica), Yale University Dagan, DIRECTORS Welt, Cornne, Massachusetts General Johnston, Janet, Queen's University Belfast Hospital Masur, Sandra, Mount Sinai School of Medicine Yin, McGill Lledias, Fernando, Institute de Biotecnologia, Hang, University Papermaster, David, University of Connecticut UNAM Health Center Assistants Lu, Xiangdong, University of North Carolina, Teaching of Medicine Chapel Hill Agoulnik, Irina, Baylor College Aldrich, Carrie, Roche Molecular Moynihan, Kathryn, Washington University Systems Berard, Mark, of Ogle, William, Stanford University University Michigan Britton, Chad, Case Western Reserve University Powers. Ralph, The University of Washington Allison, of Illinois at Proctor, Carole, University of Newcastle Brudney, University Chicago Carroll, David, Florida Institute of Rea, Shane, University of Colorado Technology Combelles, Catherine, Tufts Rutten, Bart. University of Maastricht University Curtin, Denis, of Virginia Shirasawa, Takuji. Tokyo Metropolitan Institute University of Iowa of Gerontology Galet, Colette, University Irvine Hadsell. Louise, Baylor College of Medicine Tong, Liqi, University of California, Huntress, Victoria, Tufts School of Zou, Ymg, University of Texas Southwestern University Medical Center Veterinary Medicine Jackson, Jodi, Case Western Reserve University Kalinowski, Rebecca, University of Connecticut Health Center

Kenny, Hilary, Northwestern University Frontiers in Reproduction: Kim, Julie, University of Illinois at Chicago Molecular and Cellular Concepts Klemhenz, Andrew, Case Western Reserve and University Applications Limulus eye, Robert Barlow - Magee-Womens Research May 1 9 June 29, 2002 Payne, Christopher, Institute DIRECTORS Petroff, Margaret, University of Kansas Medical Center Fazleabas, Asgerally, University of Illinois at FACULTY of California, Santa Chicago Runft, Linda, University Beebe, David, Washington University Barbara Hunt, Patricia, Case Western Reserve University Bok, Dean, Univensty of California, Los Angeles Jose, Northwestern Woodruff, Teresa, Northwestern University Santiago. University Born, Richard, Harvard Medical School Stein. Paula. of - University Pennsylvania Colley, Nansi. University of Wisconsin Madison Martha, Case Western Reserve FACULTY Susiarjo. University Gordon, Marion, Rutgers University Suszko, Northwestern University Albertini, David, Tufts University School of Magdalena, Horwitz, Joseph, Jules Stein Eye Institute, UCLA Medicine Wang, Min-Kang, Tufts University Veterinary Masland, Richard, Harvard/MGH School Ascoli, Mario. The University of Iowa Sugrue. Stephen, University of Florida Jie, of Medicine Behnnger, Richard, University of Texas Wang, Baylor College Cross, James C, University of Calgary Croy, B Anne, University of Guelph DeMayo. Francesco, Baylor College of Medicine R51

Informatics II LECTURERS Medical Informatics I Medical

- Robert, SUNY Medical University - 29 October 6, 2002 Barlow, Upstate May 26 June 2, 2002 I September Barres, Ben. Stanford Medical School Berson, Elliot., Harvard Medical School DIRECTOR DIRECTOR Medical of Wisconsin Columbia Besharse, Joseph. College Cimmo, James, Columbia University Cimino, James, University Birk, David, Jefferson Medical College Bok, Dean, University of California, Los Angeles FACULTY FACULTY of Wisconsin-Madison of Colley, Nansi, University Ackerman, Michael, National Library of Medicine Friedman, Charles, University Pittsburgh Harvard National of Medicine Dowling, John, University Bakken, Suzanne, Columbia University Kingsland, Lawrence, Library of National of Medicine Green, Carla, University Virginia Friedman, Charles, University of Pittsburgh Lindberg, Donald, Library of Wisconsin Medical Yale Griep, Ann, University Hammond, William, Duke University Miller, Perry, University Medical School Medical Center Miller, Randolph, Vanderbilt University William, of Florida College Center Hauswirth, University Kingsland, Lawrence, National Library of Medicine Medicine National of Medicine of Kohane, Issac, Children's Hospital Nahin, Annette, Library of California, Davis Hernandez, Rosano, Washington University Lindberg, Donald, National Library of Medicine Nesbitt, Thomas, University School of Medicine Vanderbilt Miller, Perry, Yale University Ozbolt, Judy, University of California, San Columbia Horton, Jonathan, University Starren, Justin, Columbia University Shortliffe, Edward, University Fransico Stead, William, Vanderbilt University Hunter, Chyren, National Eye Institute/NIH LECTURERS Children's Cincinnati Lang, Richard, Hospital, Canese, Kathi, National Library of Medicine LECTURERS National Institute/NIH National of Medicine Liberman, Ellen, Eye Cimmo, Christopher, Albert Eistein College McCray, Alexa, Library San LaVail, Jennifer, University of California, of Medicine Ash, Joan, Oregon Health and Sciences University Fransico McCray, Alexa, National Library of Medicine Moses, Marsha, Harvard Medical School STUDENTS Texas Niederkorn, Jerry, University of STUDENTS Aarstad, Robert, Louisiana State University Medical Center Southwestern Alverson, Dale, University of New Mexico Medical School NIH/NEI Utah of Health Piatigorsky, Joram, Anderson, Karen, University of North Dakota Beaudoin, Denise, Department Harvard Medical School Raviola, Elio, Bergman, Dale, Alberta Research Council Beyea, Suzanne, AORN Medical Center of Stepp, Mary Ann, GWU Binstock, Mark, Ohio Permanente Medical Group Bird, Geoffrey, Children's Hospital Philadelphia Health Services, Morehouse School of Medicine Wasson, Paul, Eye Weymouth, Bowles, Kathy, University of Pennsylvania Bowen, Elizabeth, MA of California, Bragdon, Lynn, Veterans Affairs Medical Center Contini, Janice, University Massachusetts & Ear Wiggs, Janey, Eye Infirmary Brock, Tina, University of North Carolina, Los Angeles New York School Chapel Hill Cuddy, Colleen, University COORDINATOR of Medicine COURSE Cheng, Grace, Hospital Authority Medicine Zekaria, Dania, Mount Sinai School of Chuma, Chomba, Avenue Healthcare Ltd Dnebeek, Mary, Duke University Cowen, Janet, Maine Medical Center Hughes, Christopher, Monongahela Valley STUDENTS Dee, Cheryl, University of South Florida Hospital of Bensinger, Steven, University Pennsylvania Dhara, Rosaline, Centers for Disease Control James, Veronica, Georgetown University Cusato, Karen, Albert Einstein College of & Prevention Medical Center Library Medicine Melissa, Childrens Los Erdley, William, University of Buffalo Just, Hospital Angeles Nathaniel, of Mason Medical Center Dominy, University Chicago Hayes, Barrie, University of North Carolina, Long, Susan, Virginia Stanford School of Medical Ehrhch, Jason, University Chapel Hill Mays, Brynn, Georgetown University Medicine Center Henry, Nancy, Pennsylvania State University Western Reserve General Ensslen, Sonya, Case University Kovach, Christine, Kaiser Permanente Northwest Meisel, Jim, Massachusetts Hospital of of Toronto Katz, Elizabeth, University Maryland Lambert-Lannmg, Anita, Toronto West Hospital- Mittal, Richa, University Hanna, Technion Israel Instituterof Ellen, of Minnesota Levy, University Health Network Nagle, University State Technology Luberti, Anthony, The Children's Hospital of Perley, Cathy, Empona University Polina, Massachusetts & Ear Infirmary Pimental, Sara, Kaiser Permanente Lishko, Eye Philadelphia of San McCabe, Sarah, Brown University Marazzo, Donald, Family Health Council Reavie, Keir, University California, of California, San Francisco Ortega, Nathalie, University Markland, Mary, University of North Dakota Francisco North Shore Island McCabe, Jennifer, James Madison University Reismger, Curtis, Long of San Prasad, Dipti, University California, Diego Pond, Fred, Dartmouth College Jewish Health System David, of Illinois, Connie, Duke Ramsey, University Chicago Prendergast, Neville, Washington University Schardt, University Health Reiter, Chad, Pennsylvania State University School of Medicine Schilling, Lisa, University of Colorado of Medicine Sciences Center College Raglow, Gregory, Good Samaritan Family of Health of San Shepard, Laura, University Oklahoma Practice Center Schmidt, Heidi, University California, Science Center Francisco Rangappa, Shantaram, Virginia Commonwealth Jena, Texas A&M Health Sennett, American of Cardiology Steinle, University University Cary, College Health Science Center Robertson, Nan, Kaiser Permanente-Northwest Silverman, Howard, Banner System Wei, Echo of Southern California of Tnmarchi, Michaeleen, The Research Shiyi, University Ruiz, Jorge, University of Miami School Scripps Wu, David, University of Michigan Medicine Institute Mount Sinai School of Medicine of New Mexico Yang, Ellen, Smha, Sunil, VA Maryland Health Care System Wax, Diane, University Health & Science Kaiser Permanente Zamora. David, Oregon Smith, Scott, University of North Carolina White, Mary, Annette, Vanderbilt University University Suzewits, Jeffrey, Southern Illinois University Williams, in St. Louis Zandy, Anna, Washington University School of Medicine Medical Center Zumga, Miguel, Texas A&M University Health Sciences Center

Continued.. R52

Northwestern Reese, School Methods in Computational Montgomery, Kimberly, University Amy, Washington University San of Medicine Neuroscience Nasir, Sazzad, University of California, Francisco Stembach, William, Duke University - August 4 1, 2002 September Pinto, Reynaldo, Institute de Fisica da Univ of Sturtevant, Joy, Louisiana State University Health Sao Paulo Sciences Center DIRECTORS Raffi, Milena, Rutgers University Vallim, Marcelo, Duke University Medical Center Bialek, William, F ^rsity Shahrezaei, Vahid, Simon Fraser University Van Dijck, Patrick, Flemish Interuniversity Inst. for de Ruyter van V . .ob, Princeton Stephens, Greg, Los Alamos National Laboratory Biotechnology University Louisiana Werner-Reiss, Uri, Dartmouth College Wozniak, Karen, State University Health Sciences Center Wright, Geraldme, Ohio State University FACULTV Zhou, Yi, Boston University Abbott. 3, Brandets University York Aslin, Rich; , University of Rochester, New Ermeni ut, Bard, of University Pittsburgh Neural Development and Faimali, Adrienne, Princeton University Molecular Current Genetics of Zebrafish Gelpenn, Alan, Monell Chemical Senses Center Mycology: Jensen, Roderick, Wesleyan University Approaches to Fungal August 18 -August 31, 2002 of Sao Paulo Koberle, Roland, University Pathogenesis Nancy, Boston University DIRECTORS Kopell, August 12 - August 30, 2002 Lewen, Geoffrey, NEC Research Institute, Inc Moens, Cecilia, Fred Hutchmson Cancer Research Center/HHMI Remagel, Pamela, Harvard Medical School DIRECTORS Saffran, of Wisconsin-Madison Talbot, William, Stanford Jenny, University Edwards, John, Harbor-UCLA Medical Center University Schneidman, Elad, Princeton University Mitchell, Aaron, Columbia University Shadmehr, Reza, Johns Hopkins University FACULTY of Utah Solla, Sara, Northwestern University FACULTY Chien, Chi-Bm, University Sompolinsky, Haim, Hebrew University Collazo, Andres, House Ear Institute Calderone, Richard, Georgetown University Princeton John, Harvard Tank, David, University Medical Center Dowlmg, University Tishby, Naftali, The Hebrew University Fetcho, Joseph, SUNY at Stony Brook Casadevall, Arturo, Albert Einstein College White, John, Boston Granato, Michael, University of Pennsylvania University of Medicine Hanlon, Roger, Marine Biological Laboratory Cole, Gary, Medical College of Ohio LECTURERS Kimmel, Charles, University of Oregon Filler, Scott, Harbor-UCLA Medical Center Alon, Uri, Weizmann Institute Lin, Shuo, University of California, Los Angeles Heitman, Joseph, Duke University Ayuera y Areas, Blaise, Princeton University Link, Brian, Medical College of Wisconsin Magee, Paul, University of Minnesota Doupe, Alhson, UCSF Linnon, Beth, Marine Biological Laboratory Rhodes, Judith, University of Cincinnati Fettiplace, Robert, University of Wisconsin- Mullins, Mary, University of Pennsylvania Sanglard, Dominique, University Hospital Madison Neuhauss. ETH Zurich Lausanne Stephan, Hopfield, John, Princeton University Raible, David, University of Washington London Johnston, Dan, Baylor College of Medicine LECTURERS Wilson, Carole, University College Kennedy, Mary, Cal Tech Alspaugh, Andrew, Duke University Medical Max-Planck-lnstitute LECTURERS Logothetis, Nikos, Center Menzel, Randolf, Freie Universitaet Berlin Astrofsky, Keith, Praecis Pharmaceutical Brown, Alistair, University of Aberdeen Fred Florida State Rieke, , University of Washington Fadool, James, University Gale, Cheryl, University of Minnesota Saffran, Jenny, University of Wisconsin-Madison Hopkins, Nancy, Massachusetts Institute of Goldman, William, Washington University Seung, Sebastian, Massachusetts Institute of Technology Kronstad, Jim, University of British Columbia Technology Kumamoto, Carol, Tufts University Srinivasan, MV, Australian National University TEACHING ASSISTANTS White, Ted, Seattle Biomedical Res. Inst Zucker, Steven, Yale Cooke, Julie, Fred Hutchmson Cancer Research University Yeaman, Michael, UCLA-Harbor Medical Center Center TEACHING ASSISTANT COURSE COORDINATOR Downes, Gerald, University of Pennsylvania Still, Susanne, Princeton University Durchanek, Charlme, University of Oregon Rafkin, Wendy, Harbor-UCLA Medical Center Hutson, Lara, University of Utah COURSE ASSISTANT Jennifer, of COURSE ASSISTANT Schumacher, University Pennsylvania Jensen, Kate, Princeton University Ungos, Josette, University of Washington Mitchell, Hannah, Glen Ridge High School STUDENTS COURSE COORDINATORS STUDENTS Barreto, Ernest, George Mason University Lawrence, Christian, Harvard University Andes, David, University of Wisconsin Beck, James, New York University School Lesko, Suzanna, Case Western Reserve Berbes, Carlos, Virginia Commonwealth of Medicine University University Chakraborty, Santanu, Cold Spring Harbor Perkins, Brian, Harvard University Frank, Charlotte, Yale University Laboratory Wilson, Steven, University College London Heung, Lena, Medical University of South The Rockefeller Chiappe, Eugenia, University Carolina Connell, Michael, Harvard University STUDENTS Jabra-Rizk, Man/Ann, University of Maryland, Dobbins, Heather, of Sara, California Institute of Technology University Maryland Baltimore Ahlgren, at Baltimore Campbell, Douglas, University of Cambridge MacCallum, Donna, University of Aberdeen Farries, Michael, University of Pennsylvania Dambly-Chaudiere, Christine, Universite Mayorga, Maria, Microbia Inc Gaertner, Tara, University of Texas Health Montpellier2 Morais, Flavia, Umversidade Federal de Sao Sciences Center Durr, Katnn, of Paulo University Freiburg Herrera-Vakj--z. Marco, University of Arizona Gerlach, Gabnele, Marine Biological Laboratory Nielsen, Kirsten, Duke University Medical Huys, Quen- ~.-,mbndge University Hammonds-Odie, Latanya, Spelman College Center, HHMI Lien, Cheng-C- 3 3. Physiology Institute of Leach, Steven, Johns Hopkins University Noble, Suzanne, University of California, San University h. , Malaga-Tnllo, Edward, University of Konstanz Francisco Loebel, Alex. The \A : .-mann Institute of Science Masino, Marie, SUNY, Stony Brook Ramon, Ana, Georgetown University Medical Ma, Whee Califor .nstitute of Morns, Cleveland Clinic Foundation Ky, Technology Center Jacqueline, Miller, Robyn, Cornei \ersity Panzer, Jessica, University of Pennsylvania Mirny, Leonid, Massachusetts Institute of Technology R53

Prober, David, University of Washington Renier, Corinne, Stanford University Bruce. Ashley. University of Chicago Stewart. Dana Farber Cancer Institute Rodney, Davenne. Marc, Cold Spring Harbor Laboratory of Pennsylvania Wang, Weiyi, University Dorman, Jennie, University of Washington Westerlund, Johanna, University of Helsinki Ferris. Matthew. Los Alamos National Laboratory Young, Rodrigo. Universidad de Chile Gray. Annette, Brown University Hooper. John, The Scripps Research Institute Jenik, Pablo, Carnegie Institution of Washington Kateneva, Anna, Oklahoma Medial Research Neuroinformatics Foundation August 17 - September 1, 2002 Kolb, Robert, Case Western Reserve University McCauley, Anita, Wake Forest University DIRECTORS McDonough, Stefan, Marine Biological Laboratory Brown, Emery, Massachusetts General Hospital Morgan, Jeffrey, Brown University Klemfeld, David, University of California, San Murthy, Vmit, Rice University Diego Pfeifer, Andrea, National Institutes of Health Mitra, Partha, Bell Laboratories Popoola, Joyce. King's College London Prigozhma, Natalie. The Scripps Research Institute Faculty Herb Luther Seth. Abhinav, University of Texas Southwestern Bnllinger, David, University of California, Berkeley Medical Center at Dallas Bokil, Hemant. California Institute of Technology Vaishnava, Shipra, University of Georgia Jones, Matthew, Massachusetts Institute of Fee, Michael, Bell Labs. Lucent Technologies Veklich, Yuri, University of Pennsylvania School Technology lyengar, Satish, University of Pittsburgh of Medicine Knutsen, Per, Weizmann Institute of Science Mehta, Mayank. Massachusetts Institute of Walters, Katherine, University of Iowa Kronhaus, Dma, University of Edinburgh Technology Litvak, Vladimir. Technion-lsrael Institute of Pesaran, Bijan, California Institute of Techology Technology Ketih, Cornell Medical School Purpura, Montana State McKeehan, Troy, University Rapid Electrochemical Richmond, Barry. National Institute of Mental Moravcikova, Gabriela, University of Pittsburgh Health Measurements Nicolaou, Nicoletta. University of Reading Victor, Jonathan, Weill Medical College of May 9- May 13, 2002 Reddy, Leila, California Institute of Technology Cornell University Massachusetts Institute of Sanjana, Neville, DIRECTOR Technology LECTURERS Gerhardt. Greg, University of Kentucky Medical Smith, Spencer, University of California, Los Dale, Anders, Harvard University Center Angeles Fitch, Tecumseh, Harvard University Arun, Johns Hopkins University Gardener, Dan, Cornell Medical School Sripati, FACULTY Yokoo, Takeshi, Mount Sinai School of Medicine Hu, Xiaoping, University of Minnesota Allen, Jennifer. University of Kentucky Jacobs, Gwen, Montana State University Medical Center of King, Wayne, Ohio State University Apparsundaram, Subu, University Kentucky Loader, Catherine. Bell Labs. Lucent Technologies Optical Microscopy Medical Center Center For Sensor of - Burmeister. Jason, Technology Margoliash, Daniel, University Chicago October 9 October 1 8, 2002 Miller, John, Montana State University Currier, Theresa, University of Kentucky Center Sch.ff, Nicholas. Weill Medical College of DIRECTOR Medical Cornell Davis, Heather. University of Kentucky University Izzard, Colin, University at Albany Schmidt, Marc, University of Pennsylvania Medical Center of Texas Health Strothers, Steven, University of Minnesota FACULTY Daws, Lynette, University of New York Sciences Center at San Antonio Tchernikovski, Ofer, City College DePasquale. Joseph. New York State Hoffman, Alex, National Institute on Drug Abuse Vicano. David. Rutgers University Department of Health of Medical Hard. Robert. SUNY. Buffalo Huettl, Peter. University Kentucky Center STUDENTS Keller, H Ernst, Carl Zeiss. Inc State Palmer, Michael, of Colorado Health Aldworth, Zane, Montana University Maxfield, Frederick. Cornell University University Brown Sciences Center Anderson, Bntt, University Medical College Jerome. Max-Planck-Institute for Brain Pomerleau, Francois, University of Kentucky Baron, Murray, John, University of Pennsylvania School Medical Center Research of Medicine of Porterfield. D Marshall, University of Bauer, Markus, University Nijmegen North, Allison, The Rockefeller University Bodelon, Clara. Boston Missouri-Rolla University Pierini, Lynda, Cornell University Medical Harvard Stewart, University of Kentucky Boloori. Alireza, University College Surgener, National Institutes of Medical Center Buffalo, Elizabeth, Health, Piston, David, Vanderbilt University NIMH Institutes of Health Spring, Kenneth, National Bell Laboratories/Lucent TEACHING ASSISTANTS Cimenser, Aylin, Swedlow, Jason, The University of Dundee Technologies Caulder, Tara, NIH/NIDA Diogo, Antonia, Federal University of Rio de TEACHING ASSISTANTS Knight, Tim, University of Kentucky Janeiro Parnsh, J Michael. University of Kentucky Hao, Mmgming, Cornell University Medical Enka. Brown Medical Center Fanselow, University College Massachusetts Institute of Robinson, Scott, of Kentucky Froud, Karen, Oberski, Danial, University of Buffalo University Medical Center Technology Platani, Melpomeni, The University of Dundee Grun, Max Planck Institute for Brain Sonja, Sigurdson. Wade, SUNY, Buffalo Research Snyder, Kenneth, University at Buffalo Hudson, Andrew, Weill Medical College of COURSE COORDINATOR Medical Cornell University STUDENTS Lindsay. Robin, University of Kentucky Jones. Lauren, of at Center University Maryland Ahir, Alpa, University College London Baltimore Bauer, Christoph, Universiy of Geneva Boes, Marianne, Harvard Medical School

Boxem, Mike, Dana Farber Cancer Institute Coniim : R54

STUDENTS TEACHING ASSISTANT Burk, Robert, Albert Einstein College of Medicine Almeida, Catanna, Umversidade Avem Portugal Orfila. James, University of Texas, San Antonio Burleigh, Gordon, University of Missouri- Baccei, Christopher, Merck Research Labs Columbia

i of Natural Caldwell, Ray, University of Carolina, STUDENTS Buschbom, Jutta, Field Museum Chapel Hill Black, Carlita, University of Virginia History

Cao, Bo-Jin, University of I ; lealth Sciences Cruz, Nelson, Brandeis University Caufield, Page, New York University Center Diaz, Manuel, University of Puerto Rico Conley, Catharine, NASA-Ames Research Center

I . Jr of Texas at San of Southern California Cavus, Idil, Yale , Dieguez, , Dario, University Countway, Peter, University

Concur, John, Ur . ^rsity of Illinois at Urbana- Antonio Dopman, Erik, Cornell University Champaign Gallegos, Diana, San Jose State University Fehling, Johanna, Dunstaffnage Marine Laboratory Douglas, Christopher, University of Michigan Gutierrez, Tannia, University of Georgia Flores-Ramirez, Sergio, Autonomous University French, Kristen, Medical University of South Hyde, Rhonda, Harvard University of Baja California Sur Carolina Jones, Floretta, University of Texas at San Antonio Gmzel, Matthew, University of Illinois at Urbana- Galvan, Adnana, Emory University Martinez, Veronica, Texas A&M University Champaign Herzog, Chris, Ohio State University Mendes, Shannon, University of Miami Goetze, Erica, University of California, San Diego of del Inglis, Fiona, Tulane University Padilla, Mayra, University California, Berkeley Gonzalez, Francisco, Universidad Autonoma Korean, Wayne, University of South Dakota Prather, Richard, Massachusetts Institute of Estado de Morelos

Li, Guichu, East Carolina University School of Technology Gopal, Shuba, The Rockefeller University Medicine Salas-Ramirez, Kalins, Michigan State University Gormley, Joseph, Massachusetts Biomedical Martin, Joshua, The Ohio State University Sanchez, Javier, Baylor College of Medicine Initiative Noll, Elizabeth, Bngham & Women's & Children's Torres-Reveron, Annelyn, Ponce School of Hall, Paula, University of New Mexico Hospitals Medicine Hallam, Steven, Monterey Bay Aquarium Oldenziel, Weite, University Centre for Pharmacy Wrubel, Kathryn, University of Texas Research Institute Overh, Oyvind, University of South Dakota Holder, Mark, University of Connecticut Sarter, Martin, The Ohio State University Hudelot, Cendnne, University of Manchester Schad, Christina, Chicago Medical School Jennings, Bryan, University of Texas at Austin of Universite Pierre et Mane Curie Sokoloski, Joshua, University Pittsburgh Workshop on Molecular Evolution Jolly, Marc, Jr, Robert, Ohio State Kiontke, Karin, New York University Stephens, University 28 - 2002 I July August 9, vanHorne, Craig, Brigham & Women's Hospital Komadina, Naomi, WHO Influenza Center of Staatliche Lehr-und Wagner, Amy , University Pittsburgh DIRECTOR Lange, Martin, Willis, Lauren, Medical University of South Forschungsanstalt fur Landwirtschaft Cummings, Michael, Marine Biological Carolina Langeland, James, Kalamazoo College Laboratory Zapata, Agustin, National Institutes of Health Lee, Dan, The Institute for Genomic Research FACULTY Leonard, Jennifer, University of California, Los Angeles Beerli, Peter, University of Washington Lim, Grace, Scnpps Institution of Oceanography Edwards, Scott, University of Washington Linse, Katrin, British Antarctic Survey Summer Program in Eisen, Jonathan, The Institute for Genomic Martmello, Rick, Yale Universty School of Medicine Neuroscience, Ethics, and Research Merson, Rebeka, Woods Hole Oceanographic Felsenstein, Joseph, University of Washington Survival (SPINES) Institution Kuhner, Mary, University of Washington June 15 -July 13,2002 Opazo, Juan, P Universidad Catolica de Chile Lewis, Paul, University of Connecticut Pearman, Peter, University of Zurich Meyer, Axel, University of Konstanz DIRECTORS Pie, Marcio, Boston University Rand, David, Brown University Martinez, University of Texas at San Presa, Pablo, University of Vigo Joseph, Swofford, David, Florida State University Antonio Raes, Jeroen, University of Gent Thompson, Steven, Florida State University Townsel, James, Meharry Medical College Rodriguez, Carmina, Universidad Complutense Yang, Ziheng, University College London Madrid Yoder, Anne, Yale University FACULTY Rubicz, Rohma, University of Kansas Hernandez, Ruben, University of Texas, San LECTURERS Sakwa, James, University of Pretoria Antonio Sievert, Stefan, Woods Hole Fraser, Claire, The Institute for Genomic Research Oceanographic LeBaron, Richard, University of Texas, San Institution Pearson, William, University of Virginia Antonio Sipe, Tavis, Wake Forest University Sanderson, Michael, University of California, Davis Zottoli, Steven, Williams College Smith, Catherine, Centers for Disease Control Voytas. Daniel, Iowa State University Berger-Sweeney, Joanne, Wellesley College & Prevention Yokoyama, Shozo, Syracuse University Castaneda, Edward, Arizona State University Smith, Una, Los Alamos National Laboratory Etgen, Anne, Albert Einstein College of Medicine TEACHING ASSISTANTS Stahls-Makela, Gunilla, University of Helsinki Harvard Medical School of Arizona Fox, Tom, K of Town Storz, Jay, University Bowie, Rauri C , University Cape Gonzalez-Lima, Erika, University of Texas Stuart, Gary, Indiana State University Mead, Louise, Oregon State University at Austin Terry, Rebecca, University of Leeds Rokas, Antonis, University of Wisconsin-Madison Gonzalez-Lima, Francisco, University of Texas Thomas, Bolaji, Tufts University Winka, Katarina, Umea University at Austin Tilley, Stephen, Smith College Hildebrand, John, University of Arizona STUDENTS Wang, Zhenshan, University of Washington East Jones, James M , American Psychological Whitford, Tracy, Stroudsburg University Banks, Michael, Oregon State University Association Wojciechowski, Martin, Arizona State University Behrmann, Jasminca, University of Constance Nickerson, Kim, American Psychological Wu, Martin, The Institute for Genomic Research Benavides, Edgar, Brigham Young University Association Zmser, Erik, Massachusetts Institute of Technology Borchardt, Mark, Marshfield Medical Research of Texas, Austin Foundation Zwickl, Derrick, University LECTURERS Boudreau, Ellen, Dalhousie University Burgess, David, Boston College Boyce, Sarah Lyn, Natural History Museum of Barry, NIH/IVi\ Kaplan, Los Angeles County Langford, George, D.; '_,:h College Brown, Joseph, Queen's University Mensmger, Allen, Univi .( Minnesota Budd, Aidan, Molecular Biology ' European Palazzo, Robert, University, Kansas Laboratory Zakon, Harold, University oi as, Austin Bumbaugh, Alyssa, Michigan State University Kravitz, Edward A , Harvard Medical School R55

OTHER EDUCATIONAL PROGRAMS

Marine Models in Biological Research Undergraduate Program

DIRECTORS Browne. Carole, Wake Forest University

Tytell, Michael. Wake Forest University School of Medicine

FACULTY Augustine. George. Duke University Eckberg. William. Howard University Fune. Barbara. Harvard School of Medicine Furie, Bruce. Harvard School of Medicine Gould, Robert New York State Institute for Basic Research Hanlon, Roger. Marine Biological Laboratory Jonas. Elizabeth, Yale University Laufer, Hans, University of Connecticut Malchow, R, Paul, University of Illinois, Chicago Mensinger, Al, University of Minnesota-Duluth Palazzo, Robert, Rensselaer Polytechnic Institute

Rome, Larry, University of Pennsylvania Silver, Robert, Wayne State University Wainwright, Norman, Marine Biological NASA Laboratory Planetary Biology Science Journalism Program | Internship Program STUDENTS FELLOWS Alimi, Manam, Wake Forest University DIRECTORS Bellmghim, Ruth Helena. Science Reporter. Brazil Stanford Freelance Bodily, Jill. University Dolan, Michael F, University of Massachusetts Berrcby, David, Borely, Kimberly, Ohto University Amherst Biskup, Agnes, Freelance Wake Forest Audubon Homsi, Sara, University Margulis, Lynn, University of Massachusetts Bogo, Jennifer, Magazine Jackson, Ticana, Howard University Amherst Carter, Kandice, AAAS Science Update Montanez, Marlena, Mount Holyoke College Dempsey, Dale, Freelance Najera. Julia, Univ of Texas, El Paso INTERNS Griffin, Katherme, Freelance of New A Normand, Danielle, University Allen, Michelle, The University of New South Hosteller. J , Richmond Times-Dispatch Hampshire Wales, Australia King, Robert. The Pa'm Beach Post Jessica, of Charleston Manier. Tribune O'Neal, College Chichon Garcia, Francisco J , Universidad Jeremy. Chicago Simpson, Andrew, University of California, Autonoma de Madrid Omfade. Diran, Nigerian Television Authority Santa Barbara Los Times Fike, David, University of Cambridge Perry. Rebecca. Angeles of Kansas of Steeds. Craig. University Guarin. Alejandro, The Pennsylvania State Reker, Mary Lou. Library Congress National Public Radio Online University Valentine, Vikki, Navio, Ruben Peco, Universitatsklinikum Wisby. Gary, Chicago Sun-Times Hamburg-Eppendorf Rosenfeld, Ane. University of Haifa BIOMEDICAL FACULTY Hill Vaisanen, Katarina, University of Aberdeen Beach, Dale, UNC Chapel Dale Hill Wier. Andrew. University of Wisconsin- Bloom, Kerry. Beach, UNC Chapel Milwaukee Palazzo. Robert. University of Kansas Pearson. Chad, UNC Chapel Hill SPONSORS Schnackenberg. Brad, UNC Chapel Hill Research Cabrol, Nathalie A . NASA Ames Center ENVIRONMENT FACULTY Marine Laboratory Garland, Jay. NASA Kennedy Space Center Foreman, Kenneth, Biological Marine Hagan. William, College of St. Rose Neill, Chnstoper, Biological Laboratory Hinkle, C Ross. NASA Kennedy Space Center Tholke. Kris. Marine Biological Laboratory Margulis. Lynn, University of Massachusetts Amherst CO-DIRECTORS Northwestern Robert D , Summons, Roger, Massachusetts Institute of Goldman. University Science Technology Rensberger. Boyce. Director, Knight Trent, Jonathan. NASA Ames Research Center Journalism Fellowships, Massachusetts Harvard Institute of Wofsy. Steven C , University Technology

ADMINISTRATIVE DIRECTOR Hinkle, Pamela Clapp, Marine Biological Laboratory R56

Semester in Environmental Teachers' Workshop: Living in the Microbial World Science August 10-16, 2002

' September 2 - December 16, 20C DIRECTORS DIRECTOR Dorntie, Barbara, Cambridge Rindge and Latin Eliot, Judith, Middle Years Alternative School Hobbie, John E School, Cambridge, Massachusetts for the Humanities, Philadelphia, Pennsylvania Olendzenski, Lorraine, University of Connecticut, Freitas, Caroline. Cape Cod Regional Technical ASSOCIATE DIR': Storrs High School, Massachusetts Foreman, Kenne n Golet, Gerie, Salem School, Connecticut FACULTY Goodding, Debbie, Kraemer Middle School, FACULTY Gunnard, Jessie, University of Massachusetts Placentia, California Deegan. Linda A. Offerdahl, Enka, University of Arizona Hammond, Christine, Clarendon House Foreman, Kenneth H. Grammar School, Ramsgate, Kent. United Giblin, Anne E COURSE ASSISTANT: Kingdom Hobbie. John E Waksman, George, Massachusetts Institute of Howie, Charles, Old Rochester Regional High Hopkmson, Charles S., Jr Technology School, Massachusetts Liles, George Knox, Carol, Northfield Mount Hermon School, Melillo, Jerry M PRESENTERS Massachusetts Neill, Christopher Bermudes, David, Vion Pharmaceuticals, New Lee, Marge, Harrington School, Cambridge, Peterson, Bruce J. Haven, Connecticut Massachusetts Rastetter, Edward B Dyer, Betsey, Wheaton College Lichtenstein, Leslie, Massasoit Community R Shaver, Gaius Edgcomb, Virginia, Woods Hole Oceanographic College, Massachusetts Steudler, Paul A Institution Lincoln, Peter, Hmgham Public Schools, Vallmo, Joseph J Guerrero, Ricardo, University of Barcelona, Spain Massachusetts Margulis, Lynn, University of Massachusetts, Natoli, Therese, Ledyard Middle School, Gales RESEARCH AND TEACHING ASSISTANTS Amherst Ferry, Connecticut Bahr, Michele Rogers, Dan, Woods Hole Oceanographic Potrafka, Renee, Father Gabriel Richard Catholic Bowen, Jennifer Institute High School. Ann Arbor, Michigan Creswell, Joel Kwiatkowski, Bonnie Micks, Patricia Tholke. Kris Ziemann, Tori

Administrat've Assistant Johnson-Horman, Frances

Students

Adams, Jacqueline M , Ripon College Burce, Allison E., Harvey Mudd College Copeland, Maureen T, Allegheny College Dean, Mary D,, Ripon College J Engelhart, Gabnella , Lafayette College Laurie A Fila, , Mount Holyoke College

Franklin, Jennifer M , Wheaton College J Freeman, Christopher , Connecticut College

I Haverford Havassy, Joshua , College Kang, MoonKoo Simon, Clark University Teacher Participants Pullan, Mary, Fitch Middle School, Groton, L Clarkson Kennedy, Jenny , University Barren, Melanie, Cambridge Public Schools, Connecticut E Leahy, Sarah , Wheaton College Massachusetts Roark, Eileen, Nathan Hale-Ray High School, Claire A Connecticut Leamy, , Wellesley College Berrick. Steve, Cape Cod Regional Technical Moodus,

Lmdell, Joshua S , Dickinson College High School, Massachusetts Ruston, Steve, King Etherbert School, Rachael A Skidmore United Roberts, , College Connor, Lynn, Old Rochester Regional High Birchmgton, Kent, Kingdom E El Pico Shea, Alexandra , Earlham College School, Massachusetts Tanigawa, Joy. Rancho High School, Stern, Stephanie B., Wellesley College Crook, Jolene, East Lyme High School, Rivera, California Webster, William K., Trinity University Connecticut Julie Wright, A , Wellesley College Diehl, Penny, Hempfield High School, Landisville, Pennsylvania

Microbes, Donna Bedard R57

SCHOLARSHIP AWARDS

I BURROUGHS WELLCOME FUND-MOLECULAR MYCOLOGY COURSE | Berbes, Carlos, Virginia Commonwealth University Brown, Constance, Howard University Heung, Lena, Medical University of South Carolina

MacCallum, Donna, University of Aberdeen Morais, Flavia, Universidade Federal de Sao Paulo

Noble, Suzanne. University of California. San Francisco Ramon, Ana. Georgetown University Medical Center Reese. Amy. Washington University School of Medicine

Stembach, William, Duke University Sturtevant, Joy, Louisiana State University Health Science Center

Vallim, Marcelo, Duke University Medical Center

Van Dijck, Patrick. Flemish Interuniversity Institute for Biotechnology Wozniak, Karen. Louisiana State University Heath Science Center

GARY N CALKINS MEMORIAL SCHOLARSHIP FUND

University of Sheffield E/izabeth Armstrong Berry, Katy, Copf, Ti|ana. University of Crete

I THE BRUCE AND BETTY ALBERTS ENDOWED |C LALOR BURDICK SCHOLARSHIP CONRAD |

I of East SCHOLARSHIP IN PHYSIOLOGY Dash, Satya, University Anglia Sachdeva, Geetanjali, Institute for Research in of Agutlar, Arturo, Av Institute PolitEcnico National Gonsalves, Joanna, University California, Reproduction, India Francisco Kelly, Melissa, University of Kentucky College San of Medicine Hallikas. Outi, University of Helsinki EDWIN GRANT CONKLIN MEMORIAL FUND | of Prosen, Tracy, University Pittsburgh Caracino, Diana, Emory University School AMERICAN SOCIETY FOR CELL BIOLOGY of Medicine | FUND - Brown, Ann, Medgar Evers College BURROUGHS WELLCOME Copf, Ti|ana, University of Crete of BIOLOGY OF PARASITISM COURSE Campbell, Susan, University Alabama, I Chamond, Nathalie, Institut Pasteur DAVIS Birmingham | BERNARD FUND of Davis, Kevin, University of Pittsburgh Cockburn, Ian, University Edinburgh Boucher, Yart, Dalhousie University of Gadea. Bedrick, Harvard Medical School Karnataki. Anuradha, University Washington Denef, Vincent. Michigan State University Gonsalves, Joanna, University of California, Klotz. Christian, Humbo'dt-University-Berlin Erbs, Marianne, Swiss Fed Institute for San Francisco Kooij, Taco Leiden, University Medical Centre Environmental Science & Technology School of Medicine Green, Heather, New York University Lee, SooHee, Johns Hopkins Pmel, Nicolas, University of Washington Yale Harrison, Faith, University of Iowa Li, Hongjie, University School of Livi, Carolina, University of Texas Health Sciences Mueller. Ann-Kristin, University WILLIAM F AND IRENE C DILLER MEMORIAL Center, San Antonio Medicine, Heidelberg SCHOLARSHIP FUND I Miranda, Jason, University of Texas at Austin Davis, Kevin, University of Pittsburgh FUND - FRONTIERS Pineda, Gabriel. University of Texas Health BURROUGHS WELLCOME Vega, Rebecca, Stanford University Sciences Center, Dallas IN REPRODUCTION COURSE I Akcali, Bilkent - TorrEns, Javier, New Jersey Medical School, Kamil. University I THE ELLISON MEDICAL FOUNDATION UMDNJ Bachman, Katherme, Case Western Reserve BIOLOGY OF PARASITISM COURSE I

Van Stry, Melanie, Boston University School University Chamond, Nathalie, Institut Pasteur of Kansas Medical Center of Medicine Gill. Ryan. University Cockburn, Ian, University of Edinburgh of San Vega, Rebecca, Stanford University Gonsalves. Joanna. University California. Karnataki, Anuradha, University of Washington Francisco Klotz, Christian, Humboldt-University-Bcrlm Hallikas. of Helsinki I BIOLOGY CLUB OF THE COLLEGE OF Outi, University KOOIJ, Taco Leiden, University Medical Centre Ka, of Kansas Medical of I THE CITY OF NEW YORK Hakhyun, University Mueller, Ann-Kristin, University School Zornik, Erik Columbia University Center Medicine. Heidelberg of Kayisli, Umit, Yale University School Medicine JJOHN AND ELISABETH BUCK SCHOLARSHIP Kreeger, Pamela, Northwestern University THE ELLISON MEDICAL FOUNDATION - of Thamatrakoln, Kimberlee, University of California. Perez, Christian, University Pennsylvania MOLECULAR BIOLOGY OF AGING COURSE San Diego Prosen, Tracy, University of Pittsburgh Almeida, Claudia, Weill Medical College of New Medical TorrEns, Javier, Jersey School, Cornell University UMDNJ Bishop, Glenda, Case Western Reserve Northwestern Medical School Wang, Eileen, University continued R58

Bokov, Alex, University of Texas Health Science Guest, Jennifer, National Institute for Medical Kydd, Alison, University of Calgary Center, San Antonio Research Oh, Ji-Eun, University of Illinois at Chicago Chen, Lishan, University of Washington Ihnng, Alexandra, Max-Planck-lnstitute of Pace, Margaret, University of Texas Dunaief, Joshua, University o< a Neurobiology Ramos, Arnolt, Children's Hospital

1 Fuller, Kathryn, University of f esota Malartre, Marianne, University of Portsmouth Rossi, Chiara, University of Pisa Harvey, Sarah, Medi< Virginia Nkinm, Wuyika, University of Yaounde

Hong, Eun-Jin (Eric

IALBERTO MONROY FOUNDATION Drago, Grazia. Universita Degli Studi di Palermo

PFIZER INC. ENDOWED SCHOLARSHIP Marine diatom, | Aguilar, Arturo, Av Institute PolitEcnico Ka/ma White National Chong. Curtis, Johns Hopkins School of Medicine

Pignatelli, Vmcenzo, University of Pisa

PLANETARY BIOLOGY INTERNSHIP Lien, Institute of State I SCHOLARSHIPS Cheng-Chang, Physiology Spitzer. Nadja. Georgia University Sandra. Humboldt-Universit zu Maresca, Julia, Pennsylvania State University University Freiburg Wohlgemuth, Ma, Whee California Institute of Berlin Remold, Susanna, Michigan State University Ky, Technology Edward, of Konstanz Walker. Jeffrey, University of Colorado Malaga-Trillo, University Masmo, Mark. State University of New York IMARJORIE w STETTEN SCHOLARSHIP FUND at Brook Alice, of I WILLIAM TOWNSEND PORTER FELLOWSHIP Stony Witney. University Birmingham IAND SCHOLARSHIP FUND Prober, David, University of Washington Medical School Brown, Ann, Medgar Evers College Raffi, Milena, Rutgers University Ramos, Arnolt, Children's HORACE W STUNKARD SCHOLARSHIP FUND Campbell, Susan, University of Alabama, Hospital | of Pisa Birmingham Rossi. Chiara, University Akcali, Kamil, Bilkent University Sha, Edward, Indiana Medical Center Gill, of Kansas Medical Center Davis, Kevin, University of Pittsburgh University Ryan, University Gadea, Bedrick. Harvard Medical School FLORENCE C ROSE AND S MERYL ROSE FOR GENERAL PHYSIOLOGY Gonsalves, Joanna, University of California, ISOCIETY San Francisco ENDOWED SCHOLARSHIP FUND Brown, Ann. Medgar Evers College Caracino. Diana, School Fumio Mekata Scholar, Green, Heather, New York University Emory University Dojcmovic. Danijel. of Medicine Arizona State Harrison, Faith, University of Iowa University Hu, Hailan, of California. Livi, Carolina, University of Texas Health University Berkeley Humboldt-Universit zu Science Center, San Antonio | RUTH SAGER MEMORIAL SCHOLARSHIP Wohlgemuth. Sandra, Guest, Jennifer, National Institute for Medical Berlin Miranda, Jason, University of Texas at Austin Research Pineda, Gabriel, University of Texas Southwestern Medical Center at Dallas Mitchell, Tracy, University of Wisconsin-Madison ISURDNA FOUNDATION SCHOLARSHIP De Labra. Carmen, University College London

I HOWARD A SCHNEIDERMAN ENDOWED Dellen, Babette, Washington University in St Louis (SCHOLARSHIP Doiron, Brent, University of Ottawa POST-COURSE RESEARCH AWARDS Boassa, Damela, University of Arizona College Hobbs. Steven, University of Colorado of Medicine Montana, Enrico, Massachusetts Institute Ewald, Rebecca, Cold Harbor Lab of Extavour, Cassandra, University of Cambridge (Embryology) Spring Technology De Labra, London of Health Chong, Curtis, Johns Hopkins School of Medicine (Physiology) Carmen, University College Ryan, Amy, University Virginia Systems of Ottawa Zhaolan Harvard Medical School Davis, Kevin, University of Pittsburgh (Physiology) Doiron, Brent, University Zhou. (Joe). Ge, Lan, University of California, Riverside (Physiology)

I MILTON L. SHIFMAN ENDOWED IRVING WEINSTEIN ENDOWED SCHOLARSHIP LaPointe, Nichole, Northwestern University (Physiology) | I SCHOLARSHIP Berry, Katy, University of Sheffield Khali!. Mona, Columbia University Su, Yi-Hsien, Scripps Institute of Oceanography, Kerney, Ryan, Harvard University MBRD

Torrens. Javier, New Jersey Medical School, UMDNJ I MOSHE SHILO MEMORIAL I WILLIAM MORTON WHEELER FAMILY

I SCHOLARSHIP FUND I FOUNDERS' SCHOLARSHIP Van Stry, Melanie, Boston University School of Medicine Koren, Omry, Tel Aviv University Ihnng, Alexandra, Max-Planck-lnstitute of

Vega, Rebecca, Stanford University Neurobiology (CATHERINE FILENE SHOUSE SCHOLARSHIP W. RAND FELLOWSHIP AND Avila, Andrea, Institute de Biologia Molecular WALTER L WILSON ENDOWED [HERBERT Paran -IBMP (SCHOLARSHIP FUND do I SCHOLARSHIP FUND Boassa, Daniela, of Arizona Arizona State Ahlgren, Sara, California Institute of Technology University College Dojcmovic, Danijel, University of Medicine LaPointe, Nichole, Northwestern Amarie, Dragos, University of Notre Dame University Brown, Ann, Evers Campbell. Douglas. University of Cambridge Medgar College Caracino. Diana, School WORLD ACADEMY OF ARTS AND SCIENCES Chen. Yen-Chin, National Cheng Kung Emory University of Medicine EMILY MUDD SCHOLARSHIP University Medical College Ewald, Rebecca, Cold Harbor Lab Akcali, Kamil, Bilkent Dojcmovic, Danijel, Arizona State University Spring University Fenn, University of Bachman, Katherme. Case Western Reserve Durr, Katrin, University of Freiburg Katelyn, Edinburgh Graco, Michelle, of Pierre et Gaertner, Tara, University of Texas Health University University Science Center Mane Curie Hallikas, Outi. University of Helsinki Pamela, Northwestern Perez, Christian, of Pennsylvania Goentoro. Lea. Princeton University Kreeger, University University Orsborn, of Missouri-Columbia Eileen, Northwestern Medical Sch>" Hammonds-Odie, Latanya, Spelman College April, University Wang, Katherme, Institute of Kaynar, Murat, Beth Israel Deaconess Sharp. Scripps WORLD HEALTH ORGANIZATION Medical Center Oceanography | Busso, Dolores, Buenos Aires Un:v. R60

INSTITUTIONS REPRESENTED (students)

Albert Einstein Colleqp o Medicine Harvard Medical School New Jersey Medical School, UMDNJ York Alberta Research Cc-.ncil Harvard University New University American College c' Carjtology Hebrew Universtiy New York University School of Medicine North Shore Island Jewish Health AORN Hospital Authority Long System Arizona State University Howard University Northwestern Medical School AstraZeneca R&D Charnwood, UK Humboldt-Universitat zu Berlin Northwestern University Autonomous University of Baja California Sur National Av Institute Politecmco #2508 Illinois State University Ohio Permanente Medical Group Avenue Healthcare Ltd. Ohio State Imperial College of Science, Technology University & Medicine Oklahoma Medical Research Foundation Banner Health Health Science System Indiana State University Oregon & University of State Baylor College Medicine Indiana University Oregon University Bell Laboratories/Lucent Technologies Indiana University Medical Center Beth Israel Medical Center P Universidad Catolica Chile Deaconess Institute Venezolano de Investig Cientificas de Bilkent University Institut Pasteur Pennsylvania State University College Boehringer Ingelheim Pharmaceuticals Institute de Fisica da Univ of Sao Paulo of Medicine Boston University Institute for Research in Reproduction Pennsylvania State University of Boston University School Medicine Institute de Biologia Molecular do Parana-IBMP Philipps-Universitat Marburg Brandeis University Institute de Biotecnologia, UNAM Physiology Institute of University Freiburg Brigham & Women's Hospital International School for Advanced Study (SISSA) Ponce School of Medicine Bngham Young University Princeton University British Antarctic Survey James Madison University Brown Belfast University Johns Hopkins Bloomberg School of Public Queen's University Buenos Aires University Health Johns Hopkins School of Medicine Raytheon Polar Services California Institute of Rice Technology Johns Hopkins University University Cambridge University RIKEN, Japan Carl Zeiss Kaiser Permanente Rockefeller University Carnegie Institution of Washington Kalamazoo College Royal Melbourne Hospital Case Western Reserve University Kansas State University Rutgers University Centers for Disease Control & Prevention Karolmska Institute! Medical School San Jose State Chicago King's College London University Children's Hospital Boston Scnpps Institute of Oceanography Children's of Fraser Hospital Philadelphia Leiden University Medical Centre Simon University Children's Los Smith Hospital Angeles Liverpool School of Tropical Medicine College Cleveland Clinic Foundation Los Alamos National Laboratory Smithsonian Institution Cold Harbor Lab Southern Illinois School of Medicine Spring Louisiana State University Health Sciences Center University William College of & Mary Louisiana State University Medical School Spelman College Columbia University Staatliche Lehr-und Forschungsanstaltfur Maine Medical Center Landwirtschaft Dalhousie Stanford University Marine Biological Laboratory University Dana Farber Cancer Institute Marshfield Medical Research Foundation Stanford University School of Medicine Dartmouth College Massachusetts Biomedical Initiative State University of New York at Stony Brook Doane Swiss Federal Institute for Environmental Science College Massachusetts Eye & Ear Infirmary Duke University Massachusetts General Hospital & Technology Duke University Medical Center Massachusetts Institute of Technology Dunstaffnage Marine Laboratory Max-Planck-Institute for Brain Research Technion Israel Institute of Technology Max-Planck-lnstitute for Molecular Genetics Tel Aviv University East Carolina University School of Medicine Max-Planck-lnstitute of Neurobiology Temple University School of Medicine East Stroudsburg University Medgar Evers College Texas ASM University Texas Health Science Center Emory University Medical College of Virginia A&M University School of Medicine Institute for Research Emory University Medical University of South Carolina The Genomic Empona State University MerckResearch Labs The Naval Research Laboratory Molecular The Research Institute European Biology Laboratory Michigan State University Scnpps Microbia Inc Tokyo Metropolitan Institute of Gerontology Health Council Toronto West Health Network Family Monongahela Valley Hospital Hospital-Univ Federal of Rio de Janeiro Tufts University Montana State University University Field Museum of Natural History Monterey Bay Aquarium Research Institute Flemish Interumvo^ity Institute for Morehouse School of Medicine UMass Medical School Biotechnology Mount Sinai School of Medicine United States Air Force Fox Chase Cancer University of Massachusetts, Amherst NASA-Ames Research Center Universidad Autonoma del Estado de Morelos Mason Universidad Madrid George University National Cheng Kung University Medical College Complutense Georgetown University Me iical Center National Institute for Medical Research Universidad de Chile Georgia State University National Institutes of Health Universidad Nacional de Cordoba Good Samaritan Practic-= Center Universidade Aveiro Family Natural History Museum of Los Angeles County R61

COUNTRIES REPRESENTED

Argentina Australia Belgium Brazil Cameroon Canada Ch.le China Rolf Schauder Cyanobactena, Finland France Germany Universidade Federal de Sao Paulo University of Nijmegen Greece Umversita Degli Studi di Palermo of North Carolina University India Universite Montpellier 2 of North Dakota University Israel Pierre et Mane Curie-Pans 6 Umversite University of Notre Dame Italy University Centre for Pharmacy of Oklahoma Health Sciences Center University Japan University College London of University Oregon Kenya of Aberdeen University University of Ottawa Mexico of Alabama, University Birmingham University of Pennsylvania Netherlands of Arizona University University of Pennsylvania School of Medicine Portugal University of Arizona of Medicine of Pierre et Mane Curie College University Scotland University of Birmingham Medical School of Pisa University South Africa University of Buffalo of University Pittsburgh Spam of University Calgary University of Portsmouth Sweden University of California, Los Angeles of Pretoria University Switzerland of California, University Berkeley University of Puerto Rico Taiwan of University California, Irvine University of Reading Turkey University of California, Riverside of San Lui Potosf University United Kingdom of California, San of Sheffield University Diego University United States of America of California, San Francisco University University of South Dakota Venezuela of University Cambridge University of South Florida of University Chicago University of Southern California of University Colorado University of Texas at Austin of Colorado Health Sciences Center University University of Texas Health Science Center, INSTITUTIONS REPRESENTED University of Connecticut San Antonio of Constance University University of Texas Southwestern Medical (faculty) University of Crete Center at Dallas of East University Anglia University of Toronto of University Edinburgh University of Utah of Albert Einstein College of Medicine University Freiburg University of Vigo of American Association for the Advancement University Gent University of Virginia of of Science University Georgia University of Washington American Psychological Association University of Hawaii University of Wisconsin Arizona State University University of Helsinki University of Wisconsin-Madison University of Illinois at Chicago University of Yaounde of Baylor College of Medicine University Illinois at Urbana-Champaign University of Zurich Bell Labs, Lucent Technologies University of Iowa University School of Medicine, Heidelberg BioHybnd Technologies University of Iowa College of Medicine University of Geneva Boston College University of Kansas Utah Department of Health Boston University of Kansas Medical Center University Green State University University of Kentucky College of Medicine VA Maryland Health Care System Bowlrng Brandeis University University of Konstanz Vanderbilt University Medical Center State University of Leeds Veterans Affairs Medical Center Bndgewater College Brown University University of Maastricht Virginia Commonwealth University of University Manchester Virginia Mason Medical Center California Institute of Technology University of Maryland Carnegie Institution of Washington University of Massachusetts Medtcal School Wake Forest University Carnegie Mellon University University of Miami Washington University in St Louis Case Western Reserve University University of Miami School of Medicine Weil! Medical of Cornell College University CCNY University of Michigan Weizmann Institute of Science Center For Sensor University of Minnesota WHO Influenza Center Technology Centre for Genome Research University of Missouri-Columbia Woods Hole Oceanographic Institution Centre Moleculaire University of Montana Genetique Cold Spring Harbor Laboratory University of Naples Yale University Columbia University University of Nebraska Yale University School of Medicine Cornell Medical School University of New Mexico Cornell University of New South Wales University University of Newcastle

Contmued R62

Dartmouth College New York University School of Medicine University of Connecticut Danmark Tekniske Universitet Northwestern University University of Connecticut Health Center of Duke University Medical Center Northwestern University Medical School University Dundee Duke University University of Edinburgh Ohio State University University of Florida of Eastern Virginia Medical ? : Oregon Health & Science University University Georgia of Emory University Oregon State University University Glasgow ETH Zurich University of Guelph Institute o\ Praecis Pharmaceuticals of Hawaii European , University Princeton University University of Idaho Florida Institute J| ogy University of Illinois Florida State Ui Queen's University Belfast University of Illinois, Chicago Fred Hutchir, , ancer Research Center University of Illinois, Urbana Freie Universitaet Berlin Roche Molecular Systems University of Iowa Rockefeller University University of Kansas Georgetown University Medical School Rutgers University University of Kentucky Geron University of Kentucky Medical Center San Diego State University University of Konstanz Hamamatsu Photonic Systems Seattle Biomededical Research Institute University of Lethbridge Harbor-UCLA Medical Center Sensor Technologies University of Manchester Harvard Medical School Smithsonian Institution University of Maryland Harvard University St Barnabas Medical Center University of Massachusetts Hebrew University Stanford Medical School University of Massachusetts Medical School HHMI/Brown University Stanford University University of Melbourne HHMI/Fred Hutchmson Cancer Research Center Stowers Institute for Medical Research University of Michigan HHMI/UMDNJ-RW Johnson Medical School SUNY at Buffalo University of Minnesota HHMI/UT Southwestern Medical Center SU NY at Stony Brook University of Missoun-Columbia HHMI/Johns Hopkins University Syracuse University University of Missouri-Rolla HHMI/NYU University of North Carolina, Chapel Hill House Ear Institute Texas A&M University University of Notre Dame The Hebrew University University of Oregon ICRF Clare Hall Laboratories The Institute for Genomic Research University of Oxford Imperial Cancer Research Fund The University of Iowa University of Texas Imperial College of Science Technology The University of Manchester University of Texas at Austin Institut Pasteur Tufts University University of Toronto Iowa State University Tufts University School of Medicine University of Utah Tufts University School of Veterinary Medicine University of Victoria, B C Johns Hopkins School of Medicine University of Virginia Johns Hopkins Universtiy Umea University University of Warwick Jules Stem Eye Institute, UCLA University of Pittsburgh University of Washington University of Texas Southwestern Medical University of Wisconsin Karolinska Institutet Center University of Wisconsin - Madison Kent State University University of Virginia UT Health Science Center, San Antonio King's College, London University of Texas at Austin University of California, Davis Vollum Institute Lawrence Berkeley National Laboratory University of California, San Diego London School of Hygiene and Trop Med University of California, Santa Barbara Washington University Louisiana State University Health Science Center University of California, Berkeley Washington University School of Medicine Leiden University, The Netherlands University of California, Los Angeles Weill Medical College Cornell University University of California, San Francisco Weizmann Institute Magee-Womens Research Institute University of North Caroline, Chapel Hill Wellesley College Marine Biological Laboratory University of Illinois, Chicago Wesleyan University Massachusetts General Hospital University of Kentucky Medical Center Whitehead Institute for Biomedical Research Massachusetts Institute of Technology University of Maryland, College Park Williams College McGill University University of Rochester (NY) Medical College of Georgia University of Pittsburgh Yale Medical School Medical College of Ohio University of Colorado Health Sciences Center Yale University Medical College of Wisconsin University of British Columbia Meharry Medical College University of Colorado Health Sciences Center Michigan State University University of Kansas Medical Center COUNTRIES REPRESENTED Monell Chemical Senses Center University of Oregon Montana State University University of Pennsylvania Argentina Lebanon Mount Sinai School of Medicine University of Sao Paulo Australia Mexico MPI for Medical Research University of Southern California Austria New Zealand MPl for Biological Cybernetics University of Pittsburgh School of Medicine Brazil Russia MPI for Manne Microbiology Universidad de Buenos Aires Canada South Africa MRC Lab of Molecular Biology Universitaet Ulm China Sweden Memorial Sloan Kenenng Cancer Center University College London Columbia Switzerland Lausanne University Hospital Denmark Taiwan National Institute on Aqing, NIH University of Aberdeen France The Netherlands National Institute for M.-J.ca! Research University of Alabama

: Germany Turkey National Institute of Me";, '^alth University of Arizona Greece United Kingdom National Institute on Druq University of Bern India United States of Americ National Institutes of Health University of Calgary Indonesia National Library of Medicine University of Cambridge Ireland NEC Research Institute, Inc University of Cape Town Israel New England Medical Center University of Chicago Italy New York University University of Cincinnati Jamaica R63

mbl/whoi library

REPORT OF THE LIBRARIAN

Libraries are the computer-age doorways to information systems worldwide. Today the MBL/WHOI Library uses an integrated set of resources for online cataloging, resource sharing and reference

services, with local and regional systems linking Woods Hole with

large universities and museums all over the world. Libraries like ours

are now essentially borderless. With increases in journal pricing and shrinking budgets, libraries must collaborate with other institutions more and more to deliver information that their users require.

Digitization technology which enables the one-time transformation will increase of information from print to electronic format only collaborations and encourage the sharing of information over time. Thanks to this technology, important articles, books, and images once at risk of being lost forever on a dusty shelf can be stored and

delivered electronically to users around the world. The MBL/WHOI of the Library has shown this to be true with the successful digitization The MBL/WHOI Library maintains one of the Leuckart charts, which have been available on the Library's web site world's largest print and electronic collec- since 1 996. Over the years, hundred of thousands of people from tions of biomedical, and oceanographic, th around the world have rediscovered these 19 century teaching marine biological literature. It is jointly which are still useful operated with the Woods Hole Oceano- charts, very today. graphic Institution. The main library is to in non-traditional direc- located in the MBL's Lillie Building, with The MBL/WHOI Library continues grow branches on the campuses of the Woods tions. We are developing innovative digitization services and Hole and the National online taxonomic Oceanographic important new research tools, including X-ID, an key, Marine Fisheries Service in Woods Hole. funded by the Jewett Foundation, and uBio, a network taxonomic name server funded by the Andrew W. Mellon Foundation. Through alliances with these two pilot projects we have established global

GBIF (Global Biodiversity Information Facility) and ITIS (Information Taxonomic Information Service) and bolstered our relationships with

museums. Currently, we are creating a digital archive for the MBL

Herbarium of local fauna and marine algae. A very enthusiastic group of MBL Associates is scanning the specimens for the project, which is funded by SeaGrant. Continued R64

the In 2002, we aggressively moved more Library content and serial and database usage statistics and surveyed and supporting services to the web for direct delivery to the scientific community about how current subscriptions were their needs. Discus- patron. By the end of 2002, the MBL/WHOI Library was exchange programs meeting of sions resulted in substantive to the 2003 serial delivering appro-r -ly 52% of our serials and 100% changes

our database? ' outed, electronic form extending collection, including a cut back of long-standing ex- our at the and These the Library' ;rh beyond our walls to wherever change programs MBL WHOL changes

- patrons " ) be twenty-four hours a day, seven days a reflect input from librarians and members of the commu- week. We continued to improve existing services with the nity on a number of factors: survey responses; the enhancement of our web site (www.mblwhoilibrary.org/). community's request that we subscribe to the Web of

We also continued to invest in the Library's future through Science database; rising serials prices; expiring ejournal

major expenditures, projects, technological platforms, contracts being replaced with higher-cost alternatives; in Lillie a decrease support systems and replacement of current infrastructure space constraints the Building; and 4% and computer technology that support existing library in the MBL-serials budget line. services.

The Library hosted 1 1 9 Readers taking sabbaticals, Monographs

working on writing projects, or conducting long-term We continued to titles for the book and research projects. The wireless network installed in 2002 acquire special/ our and brought Internet access to the stacks and reading rooms. named collections using general budget specific funds the Aron, and Mullin funds. Ironically, we have declared the Grass Reading Room to including Atwood, gift The libraries were with the addition be a "technology free" zone to maintain a quiet, contem- WHOI ship updated of new reference as well as recreational materials. plative space in a Library that has resolutely embraced reading The Clark Room was dismantled to electronic information delivery. Reading completely reorganize staff workspace. Non-duplicate Clark materi- als were filed with the mam book collection (3rd floor

Lillie), which was completely shifted. In addition, all stacks were relabeled.

Special Collections

Dedicated staff and volunteers continued to make great

strides in Special Collections. The MBL Archives pro-

cessed the reprint collection of Viktor Hamburger, John Burris' Director's papers, James Ebert's scientific and Director's papers, and the Arthur Humes collection of

glass plates, slides, and photographs. We also restored and rebound 130 items from Rare Books/Special Collec- tions with the support of the Florence Gould Foundation. The WHOI Data Library & Archives (DLA) continued to Serials process and catalog their extensive collection of technical | reports, maps, scientist's papers, ship cruise reports and We made a smooth transition to a new serials vendor, logs, etc. They spent a considerable amount of time Alvm media to newer EBSCO, and escaped the turmoil our former vendor migrating and other data from old formats. Both MBL and WHOI Archivists are created when it declared bankruptcy and stranded major raising for the need of institutional records academic libraries with loss of access to journals. The awareness manage-

Library realigned serial holdings and services to better ment plans. support current scientific research interests. We analyzed R65

LIBRARY READERS

Laczko, Jozsef. New York Courses Abbott, Jayne, Marine Research. Inc University Laderman, Aimlee. Yale Ahmad|ian, Vernon, Clark University University Brandeis Allen. Garland. Washington University Lisman, John. University Harvard Linck, Richard, Umersity of Minnesota Library staff gave 37 general library Anderson, Everett, University Llinas. Rudolfo, New York University orientations or Loewenstem, Werner. Journal of Membrane department-oriented Baccetti. Bacoo, NRC of Siena. Italy sessions and taught 25 courses in Benjamin. Thomas Harvard Medical School Biology Lorand. Laszlo, Northwestern Bernhard. Jeffery, University of Massachusetts University 2002. Trainers were in from brought Medical Center Medical School Ohio several specific databases to do in- Borgese, Thomas, Leaman College, CUNY Luckenbill, Louise, University Bower. James, of Texas, San Antonio sessions. In University depth training conjunc- Anna, CNR-SISSA Boyer, John, Union College Menmi, tion with our Spring and Fall Medical Milkman, Roger, University of Iowa of Puerto Rico Miller, Andra, NIH Informatics courses, new interactive Candelas, Graciela, University Harvard Cariello, Lucio, Stanzione Zoologica "A Dohrn" Mitchell, Ralph, University student web were Rush St Lukes pages designed, Chang, Donald, Hong Kong University Morrell, Leyla, Presbyterian and course packs were made avail- Child, Frank, Trinity College Clarkson. Kenneth, Bell Labs Nagel. Ronald. Albert Einstein College of Medicine able over the web. Northwestern Cohen, Seymour, American Cancer Society Narahashi, Toshio. University John. NASA Cook. Erik, Howard Hughes Medical Center Naugle. Sherwin, University of in Cooperstein, Our staff actively participated State | Connecticut Plummer Cobb, Jewel, California University Johns professional development activities Copeland. Eugene. Woods Hole, MA Prendergast, Robert, Hopkins University Corwin, Jeffery, University of Virginia and contributed to the profession as Couch, Ernest, Texas Christian University \a whole. This serves to promote D'Alessio, Giuseppe, Universita di Napoli MBL/WHOI Library projects and it Fedenco II our staff to new ideas and exposes Davis, Jonathan, Lexigen Pharmaceuticals methods. DLA staff hosted a meeting Donavan, Erin, Auburn University Dube, Francois. St. Luc, Canada of the Marine Technology Society Duncan. Thomas, Nichols College concerning scientific instruments. Epstein, Herman, Brandeis University The Library Director and Associate

Director also served on various task Fmkelstein, Alan. Albert Einstein College of Medicine forces involved in developing a

strategic plan for the MBL. Fraenkel, Dan, Harvard Medical School Frenkel, Krystyna, New York University School of Medicine The MBL/WHOI Library continues to Harvard an electronic between Galatzer-Levy, Robert, University of Chicago Rabmowiu. Michael, University serve as bridge MA Gancia-Blanco, Mariano. Duke University Rafferty, Nancy, Falmouth. Hole and the world Woods providing Medical School Reynolds, George, Princeton University of access to collections at universities, German, James, Cornell University Rome, Larry, University Pennsylvania Harvard Medical School Grossman, Albert, New York University Medical Ruderman, Joan, and in public, corporate, private, School The Council museum, and laboratory libraries Gruner. John, Cephalon, Inc Segal, Sheldon, Population Sheng, Morgan, Massachusetts Institute around the globe. Halvorson, Harlyn, University of Massachusetts, of Technology Boston Shephard, Frank, Woods Hole Data Base MA Catherine N. Norton Harrington, John, SUNY New Paltz Shimomura, Osamu, Falmouth, Northeast Fisheries Science Center Herskovits. Theodore, Fordham University Smith. Tim, Solomon, Dennis, Yarmouth Port. MA of Inoue, Sadayuki. McGill University Spector, Abraham, College Physicians & Surgeons Mote Marine Lab Jaye, Robert, Boston Spotte, Stephen, School Jacobson, Allan, University of Massachusetts Steinberg. Martin. Boston University Medical Center of Medicine of North Carolina Josephson, Robert, University of California Stuart, Ann. University Sullivan, Gerald, Savio Prep-Boston Kaltenbach, Jane, Mount Holyoke College Yale Karlin, Arthur, Columbia University Tnnkhaus, John, University of Notre Dame Kelly, Robert. Woods Hole, MA Tweedell. Kenyon. University Keynan, Alexander. Israel Academy of Sciences Tycosmski, Mark. University of Pennsylvania & Humanities Cavendish King. Kenneth, Falmouth, MA Walton, Alan, Laboratory Knox, Carol, Northfield Mount Herman Warren. Leonard, University of Pennsylvania York Kornberg. Hans. Boston University Weissmann, Gerald. New University Krane. Stephen, Harvard Medical School Medical Center Whittaker. J Richard. University of New Brunswick Woods Hole Research Center R66

financials

REPORT OF THE TREASURER

The financial results for 2002 reflected the difficult operating environ-

ment in a year where all non-profits were adversely affected by two major trends: the continued decline in the investment markets and a softening of philanthropic support.

The Unrestricted Operating results showed a loss of $1.76 million, which was a vast improvement over the $2.9 million loss reported in 2001. This was due to a more rapid increase (14.4%) in Unrestricted Operating Support when compared to Operating Expense growth (9.6%). On the revenue side, Government Grants increased by 8.2%, Lab Rental & Net Tuition increased by 12%, Fees for Conferences and Services rebounded 21 .7% from depressed levels in 2001 as a result of cancelled events due to September 1 1"\ and Investment and Other Revenues increased by 30%.

On the expense side. Research activities represented two-thirds of the increase, growing by approximately $2 million (9.7%) as the Laboratory added more than two dozen scientists mainly to gear up for expanded research programs in Scientific Aquaculture and Global Infectious Disease. As a result, grant applications hit an all-time high and grant

dollars awarded increased almost 30% over 2001 . Looking at the underlying components, double-digit increases were experienced in Salaries (13.6%), Fringe Benefits (16.2%), Supplies (19.4%), Utilities (12.1%), and Depreciation (16.8%).

Philanthropic support fell dramatically from the unusually strong levels the Laboratory had experienced in the three previous years when the Total Contribu- MBL received gifts exceeding $10 million each year.

tions including those to Plant were $4.6 million, the lowest level since

1995. The long-term investment portfolio, however, performed quite fund competitively in a year when the average common stock mutual declined by 28%. The 3.9% decline in market values was in the top

a universe of 1 22 foundations and quartile when compared to how endowments performed in 2002. The MBL had realized and unrealized investment losses, which totaled $2 million in 2002.

Taking into account the challenging near-term market environment, in 2002 the Laboratory experienced its first decline in Total Net Assets since 1994. MBL's Net Assets declined $6.2 million. R67

The MBL's Balance Sheet Assets reflected this impact, In summary, it was a challenging year financially mainly due to the effect the third consecutive of investment declining by $7.1 million. The entire decline was concen- year trated in Short Term Investments and Pledge Receivables. market declines had on MBL's philanthropic support and investment out of our The Endowment held up due to the receipt of new portfolio. Coming strategic Plant & effort we have started permanently restricted gifts. Property, Equipment planning already implementing also held steady as $2.4 million in improvements more steps that will position the Laboratory for a strong rebound in our Government Grants and to than offset the accrued depreciation. Liabilities declined ultimately the relin- for a new that should by approximately $1 million, principally due to gear-up capital campaign improve summer/ quishment of a Unitrust to the benefit of the Laboratory. our philanthropic support. Our education, visiting scientist, and conference activities remained and when with the resident Considering some financial performance ratios, our Return strong combined expanded continue to on Average Net Assets was a negative 6.7%, which is in research programs should help us improve our results in the line with most non-profits during this period. The MBL's operating near future. Leverage Ratio (Unrestricted & Temporarily Restricted Net Assets/ Debt) remains sound at 4.48X. Also, both our Debt B. Conrad Service Coverage ratio of 1 .72X for 2002 and our non- Mary permanently restricted Cash & Investments of $25.6 million at year-end are well in excess of the financial covenants of the Letter of Credit supporting the MBL's Long Term Debt.

Lobster eyes, Diane Heck. David Ramsey, Lydia Louis, and Jeff Laskin R68

FINANCIAL STATEMENTS

and Balance Sheet as of December 31 2002 2001 . Operating History , and

BALANCE SHEET (In Thousands) 2002 2001

ASSETS: Cash and Short Term Investments $4.357 $8.993 Pledges and Other Receivables 8.794 11,265 Assets Held by Bond Trustee 269 Other Assets 631 711 Endowment and Similar Investments 42.290 42.181 Property Plant and Equipment (Net) 31.729 31,519

TOTAL ASSETS: 87.801 94.938

LIABILITIES.

Accounts Payable 2,797 3,133 Annuities and Unitrusts Payable 535 1,383 Deferred Revenue and Other Liabilities 2.557 2,318 Long Term Debt 10,200 10,200

Total Liabilities: 16.089 17,034

NET ASSETS- Unrestricted 20,381 22.261 The financial statements of the Temporary Restricted 25.278 29.941 Marine Biological Laboratory, for Restricted the fiscal year ending December Permanently 26,053 25,702 31. 2002. were audited by Pr/cewaterhouseCoopers. LLP Total Net Assets: 71.712 77.904

financial statements are Complete TOTAL LIA8ILITES AND NET ASSETS: $87.801 $94,938 available upon request from:

OPERATING HISTORY (In Thousands) Mr Homer Lane Chief Financial Officer OPERATING SUPPORT: Marine Biological Laboratory 7 M8L Street Government Grants $15.849 $14,648 Woods Hole. MA Private Contracts 1.495 1,675 02543-1015 Lab Rental and Net Tuition 2,188 1,954 Fees for Conferences and Services 5.333 4.383 Contributions 4.522 10.886 Investment and Other Revenues 3,321 2.555 Total Operating Support 32,708 36,101

EXPENSES: Research 22,371 20.399 Instruction 5.998 5.637 Conferences and Services 1.460 1.133 Other Programs 5.027 4.643 Total Expenses: 34.856 31.812

CHANGE IN NET ASSETS BEFORE

NON. OPERATING ACTIVITY. (2,148) 4.239

Non-Operating Activities. Contributions to Plant and Other Expenses, Net (149) 2,244

Total Investment Income and Earnings (1,994) (2.930) Less Investment Earnings Used for Operations (1,901) (1.475) Reinvested (Utilized) Investment Earning (3.895) (4,405)

TOTAL CHANGE IN NET ASSETS: $(6.192) $2.128 R69

gifts

REPORT OF THE DEVELOPMENT COMMITTEE

As the MBL engaged in institution-wide strategic planning during this past year as described by forward Dr. Speck earlier in this report, 2002 was a pivotal year for Development efforts. Moving educational after our spectacularly successful Discovery Campaign with new research and pro- education activities grams now in place, we turned our attention to broadening our outreach and through a series of events and communications.

P/anlcromc sarcodme The Host

DNA is heated within the dark. Last summer, we held an enjoyable and informative Day of Science attended by 92 guests from centra/ nuc'ear capsule. The communities that included MBL scientists and lab tours. The Council of symbionts are the sma// bright nearby presentations by specks radfatmg outward along the Visitors meeting drew 80 friends from across the country to learn about Modem Molecular host spines, David Caron Approaches to Global Infectious Diseases and to tour the totally refurbished suite of laboratories for the newly established research program in this area. As in past years, our summer lectures and the MBL. childrens' programs in Nantucket and Martha's Vineyard spread the word about We branched out in 2002 and held our first-ever alumni reception in Chapel Hill, North Carolina, and friends of the Lab. attended by 65 course alumni and faculty, MBL Corporation Members,

is MBL's web site so we And, turning to the Internet, Development information now featured on

can effectively extend our message to a world-wide community.

from the Andrew W. In 2002, MBL raised $4,944,803 in private support. This included $1 ,350,000 Mellon Foundation in renewed support for terrestrial forest research and support for a new pilot about that is distributed on the project designed to index and organize information organisms Internet. MBL Council of Visitors member, Robert Shifman, provided an additional gift of $564,502 to the Milton Shifman Endowed Scholarship The G. Linger Vetlesen Foundation Center unrestricted continued its generous and long-standing support for the Bay Paul and and the Wellcome support. The Ellison Medical Foundation, the Grass Foundation, Burroughs in and biomedicme. Fund all provided renewed support for MBL's advanced courses biology

both new The 2002 Annual Fund had another strong year with $553,620 raised from 898 donors of donors are both records in annual fund giving at the MBL. The amount raised and numbers up of donors whose of by 9% over last year. As in past years, the Whitman Society, comprised gifts for $1,000 or more accounted for much of this success. I would like to thank Dr. Peter Armstrong the Annual Fund drive for the serving as Annual Fund Chair and Mr. Michael Fenlon for leading for the Associates. We are enormously grateful for this unrestricted support Laboratory.

On behalf of the Development Committee, the Board of Trustees, and the entire MBL community, whose names on the I would like to express my appreciation to the donors appear following pages, and to those who requested anonymity. We are all most grateful for their generous and educational support for the Marine Biological Laboratory's research programs.

Christopher M. Weld, Chair, Development Committee R70

HIGHLIGHT!

During 2002, Ecosystems Center Staff the following members map out a research foundations and ; plan, Elizabeth Armstrong individuals provided major support for the Laboratory.

Burroughs Wellcome Fund awarded $170,000 I Mr. Robert Shifman made an additional gift of for continuing support of the Molecular $564,502 to support the Milton L. Shifman Mycology course. Endowed Scholarship. Mr. Shifman was a member of the Council of Visitors. The Ellison Medical Foundation awarded

$282,670 for continuing support of the G. Linger Vetlesen Foundation provided Molecular Biology of Aging Colloquium for $150,000 for the Josephine Bay Paul Center the period 2002 through 2004. in Comparative Molecular Biology and Evolution; $100,000 in support of the The Grass Foundation awarded $226,500 in program to develop marine models for renewed funding for the Neurobiology and biomedical research; and $100,000 to

Neural Systems and Behavior courses. underwrite veterinary services in the Marine Resources Center. Andrew W. Mellon Foundation awarded two

grants totaling $1,350,000: $850,000 to support research on nitrogen transformation in terrestrial landscapes conducted by The Ecosystems Center and $500,000 to launch

the Universal Biological Indexer and Orga-

nizer (uBio), a database and internet tool to

provide up-to-date biological information.

Neura/ system cone mossaic, Inigo Nova'

SPECIAL GIFTS

Other Gifts

American Society for Biochemistry & Molecular Biology

Mrs KimballC Atwood, III Aquatic Eco-systems, Inc Ms Susan M Barnes Josephine Bay Paul & C Michael Paul Foundation Bio-Rad Dr Barry R Bloom Mr and Mrs Thomas C Bolton Mrs Carolyn S Carlson Dr Eloise E Clark Drs William and Marion Cohen Dr Seymour S Cohen Elsevier Science Ireland Ltd Drs Lawrence Cohen and Barbara Ehrlich Federation of American Societies for Experimental Biology Fluke Corporation Friendship Fund Dr and Mrs Harold Gainer Drs Robert and Anne Goldman Dr and Mrs J Woodland Hastings Dr Robert R Haubnch A variety of foundations, individuals, and companies provided Mr and Mrs Irwm Herskowitz funds for special projects and programs at the Marine Biological Mrs Carmela J Huettner Mr and Mrs Richard A Huettner Laboratory. We gratefully acknowledge their support. Dr and Mrs Shmya Inoue Mr David Isenberg and Ms Paula Blumenthal Invitrogen

Dr Wallace Ip Mr Daniel Gifts Isenberg Major Dr. and Mrs Benjamin Kaminer Dr Andrew Kropmski and Dr Peggy Pntchard Anonymous (2) Dr Kiyoshi Kusano American Society for Cell Biology Dr Hans Laufer American Society for Reproductive Medicine Mr Richard Mawe Applied Biosystems Merck Research Laboratories Cox Foundation, Inc Ms Natalie Miller Estate of Emily Ann Cramer Dr Betty C Moore Environmental Data Research Institute Ms Mary Musacchia and Dr James Faber ExxonMobil Foundation Mr Telephone, Inc Georgia-Pacific Corporation New England Biolabs, Inc Mr William Golden and Dr Jean Taylor Ms Catherine N Norton Howard Hughes Medical Institute Novartis Dr and Mrs Kurt J Isselbacher Dr and Mrs Philip Person Mr and Mrs George W Logan Pharmacia & Upjohn Company The Mantia Family Trust PhotoArk Massachusetts Environmental Trust Estate of Madelene E Pierce The Honorable and Mrs G William Miller Princeton Day School New York Times Company Foundation Promega Corporation Nikon Instruments Inc Qiagen, Inc The Pfizer Foundation Dr and Mrs Harris Ripps Mrs Robert W Pierce Dr Raja Rosenbluth William Townsend Porter Foundation Mr and Mrs William Rugh Dr and Mrs John W Rowe Schenng-Plough Research Institute

The Schooner Foundation Smauer Associates Inc . Publishers Sholley Foundation, Inc Dr Sol Sepsenwol The Catherine Filene Shouse Foundation Dr Abraham Spector and Ms Marguerite Filson Alfred P Sloan Foundation Drs Melvn and Evelyn Spiegel Society for Neuroscience Mrs Eleanor Stembach The Seth Sprague Education & Charitable Foundation Syngenta Drs William Speck and Evelyn Upper Dr and Mrs Andrew G Szent-Gyorgyi The Sprague Foundation Ms Natalie Trousof Drs Albert Stunkard and Margaret Maurin United States Geological Survey Mr and Mrs Gerard I Swope Dr Dale A Webster Universal Imaging Corporation Dr and Mrs. Gerald Weissmann Mr Sidney J Wemberg, Jr Mrs Clare M Wilber The Irving Wemstein Foundation, Inc. World Health Organization Mr and Mrs Christopher M Weld World Precision Instruments The Worthmgton Family Foundation, Inc R72

THE WHITMAN SOCIETY

1 " Mem.' j in the Whitman Society is open each year to individual donors who

' . (e $1,000 or more to the MBL Annual or Alumni Funds.

Director's Circle Mr William T. Golden Gmny and Pete Nicholas | Massachusetts American Museum of Natural History, Boston, Anonymous New York, New York Arthur B. Pardee and Ann B. Goodman Massachusetts Dr. Porter W. Anderson, Jr. Mr. and Mrs. Amos B. Hosteller Jr. Cambridge, Massachusetts Key Largo, Florida Boston, Mr. Manus A. Robinson Florida Mr. and Mrs William C Cox, Jr Dr. Laurie J. Landeau Key Biscayne, Hobe Sound, Florida Northport, New York Drs Mitchell Sogin and Laurel Miller Fa/mouth, Massachusetts Dr. and Mrs. Kurt J. Isselbacher Robert A. Prendergast Newton Center, Massachusetts Fa/mouth, Massachusetts Mr. and Mrs. John C. Stegeman Ann Mr. and Mrs. George W. Logan Mr. and Mrs. Richard Reiss Arbor, Michigan New York Salem, Virginia New York, Drs. Ann E. Stuart and John W. Moore North Carolina The Honorable G William Miller Harriet and Sheldon Segal Chapel Hill, Washington, DC Hartsc/ale, New York

Mrs. Robert W. Pierce Boca Florida Grande, Member Patron | | Mr. Vin Ryan and Ms. Carla Meyer Edward and Marion Adelberg Boston, Massachusetts Anonymous New Haven, Connecticut

Dr. and Mrs. John W. Rowe Frank and Mardi Bowles Dr Louise Adler New York, New York Woods Hofe, Massachusetts Fa/mouth, Massachusetts

Drs. William and Speck Evelyn Upper Mr. and Mrs. Malcolm K. Brachman Dr Garland E Allen Massachusetts West Fa/mouth, Dallas, Texas Saint Louis, Missouri

Mr. Sidney J. Wemberg, Jr. Mr. and Mrs. Murray H Bring Mr and Mrs Douglas F Allison New York, New York East Hampton, New York Bloomfield Hills, Michigan

Drs and Clara Dr and Mrs Gerald Weissmann Drs Claire Fraser and J. Craig Venter Clay Armstrong New York, New York Potomac, Maryland Philadelphia, Pennsylvania

Peter and Mr. and Mrs. Christopher M Weld Frances and Howard Jacobson Margaret Armstrong Davis, California Essex, Massachusetts Westborough, Massachusetts

Dr Samuel C Armstrong Mr. and Mrs Alfred M Zeien Dr. and Mrs. Stephen M. Krane Everett, Washington Boston, Massachusetts Waban, Massachusetts Jean and Bob Ashton M.D. Catherine C. Lastavica, New York, New York Benefactor Manchester, Massachusetts ] Mr and Mrs David Bakalar

Diane and Norman Bernstein Dr. and Mrs. Leonard Laster Chestnut Hill, Massachusetts Washington, DC Woods Hole, Massachusetts Mr and Mrs Charles A Baker New Mr, and Mrs. Jonathan Conrad Dr. Anna Logan Lawson Princeton, Jersey New York, New York Daleville, Virginia Drs Robert and Harriet Baker White New York K Plains, Mr. and Mrs. Diarmaid Douglas-Hamilton Birgit Rose and Werner Loewenstem Massachusetts Fa/mouth, Massachusetts Beverly, David Baltimore and Alice S Huang Pasadena, California R73

Mrs Fredenk B Bang Mr and Mrs Frank C. Carotenuto Mr and Mrs David L Douglass Woods Hole, Massachusetts East Fa/mouth, Massachusetts Woodside, California

and Mel Barkan Hope Dr and Mrs Richard L Chappell Judith and John Dowhng Boston, Massachusetts New York, New York Boston, Massachusetts

Dr and Mrs Robert B Barlow Frank and Julie Child The Jane and Allan Dragone Foundation Jamesville, New York Woods Hole. Massachusetts Vero Beach, Florida

Fred and Christine Bay Dr Eloise E Clark Mr and Mrs George Edmonds Landgrove, Vermont Bowling Green, Ohio Osterville, Massachusetts

Bruce Anthony Beal Mr. and Mrs Hays Clark Mr and Mrs Hans A Ege Woods Hole, Massachusetts Hobe Sound, Florida Mahwah, New Jersey

Drs Eugene and Millicent Bell Mr and Mrs James M Clark Drs Herman N. Eisen and Natalie Aronson Boston, Massachusetts Palm Beach, Florida Waban, Massachusetts

Drs Michael and R Suzanne Bennett Arnold and Connie Clark Mrs Ariana Fairbanks New Rochelle, New York Woods Hole, Massachusetts Honolulu, Hawaii

Mrs. Beth Berne Drs Alexander W Clowes and Susan E Detweiler Dr. A Verdi Farmanfarmaian Woods Hole, Massachusetts Seattle, Washington Princeton, New Jersey

Jewelle and Nathaniel Bickford Mrs George H A. Clowes Ms Linda Sallop and Mr Michael Fenlon New Yoric, New Yorlc Dover, Massachusetts Newton, Massachusetts

Mr F and Mrs Eric Billings Dr Jewel PlummerCobb Mrs James J Ferguson Jr Potomac, Maryland Los Angeles, California Chevy Chase, Maryland

Dr and Mrs Elkan R Blout Drs. Arthur L, and Laura H Colwin Mr and Mrs Harold E Foreman, Jr Cambridge, Massachusetts Key Biscayne, Florida Northbroolc, Illinois

Mr Allen Bragdon Dr and Mrs D Eugene Copeland Drs Bruce and Barbara C Furie South Yarmouth, Massachusetts Woods Hole, Massachusetts Wellesley, Massachusetts

Dr and Mrs Goodwin M Breinm Molly N Cornell Dr and Mrs David C Gadsby New Yorlc, New York Falmouth, Massachusetts New York, New Yorlc

Dr and Mrs. John B Buck Dr William B Cosgrove Ms SalheGiffen Sykesvtlle, Maryland Pittsboro, North Carolina Falmouth, Massachusetts

Mr and Mrs N Harrison Buck Dr Joseph T Coyle Rebeckah DuBois Glazebrook Princeton, New Jersey Belmont, Massachusetts Osprey, Florida

Dr Max M Burger Thomas and Geraldine Crane Dr and Mrs Murray Glusman Basel, Switzerland Weston, Massachusetts Woods Hole, Massachusetts

Dr and Mrs Mario Burgos Dr and Mrs Stephen D Crocker Suzanne and Maynard Goldman Mendoza, Argentina Bethesda, Maryland Boston, Massachusetts

Rick and Nonnie Burnes Drs Mrs Sally Cross Robert and Anne Goldman Butler's Hole Fund Falmouth, Massachusetts Chicago, Illinois Boston, Massachusetts Dr and Mrs Anthony J Cutaia Drs Timothy and Mary Helen Goldsmith Mr and Mrs Malcolm Campbell Ballwin, Missouri Northford, Connecticut Upper Montcla/r, New Jersey Vineyard Haven, Massachusetts Mr and Mrs Bruce G Daniels Dr and Mrs Moise H Goldstein, Jr Lincoln, Massachusetts Woods Hole, Massachusetts Dr Graciela C Candelas

San Juan, Puerto Rico Dr Eric H Davidson Susan and Tom Goux Pasadena, California Teahclcet, Massachusetts

Continued R74

Dick and Eleanor Grace Dr Gertrude W Hinsch Mr and Mrs Robert P Lambrecht The Brain Center Thonotosassa, Florida Boca Grande, Florida Mew Seabury, Massachusetts John and Ohvann Hobbie Mr and Mrs Rudy Landry Fa/mouth, Massachusetts Philip Grant Pocasset, Massachusetts Washington, DC Drs F Hoffman and Elena Gtkowitz Joseph Homer W and Mary Cronan Lane

< Connect/cut Dr Michael J and Mr :a H Greenberg New Haven, North Fa/mouth, Massachusetts St Augustine, Florida Dr. Francis C G Hoskin and Mrs Nancy Norman Lassalle Elizabeth M Farnham Dr Mary J Greer New York, New York Massachusetts New York, New York Canton, Dr Hans Laufer Mrs. Carmela J Huettner Mr. and Mrs William H Greer, Jr Storrs, Connecticut Massachusetts Chevy Chase, Maryland Woods Hole, Mr Joel A Leavitt Hunter Dr and Mrs Thomas C Gregg Mr and Mrs Charles Boston, Massachusetts Fa/mouth, Massachusetts Kansas City, Missouri

Mrs J K Lilly, III Paul R and Mona Gross Dr. and Mrs Hugh E Huxley West Fa/mouth, Massachusetts Jamaica Plain, Massachusetts Concord, Massachusetts Dr and Mrs Anthony Liuzzi Dr and Mrs Lawrence Grossman Dr and Mrs Shmya Inoue Boston, Massachusetts Baltimore, Maryland Fa/mouth, Massachusetts Laszlo and Joyce Lorand Dr. and Mrs Harlyn O Halvorson Mary D Janney Glencoe, Illinois Woods Hole, Massachusetts Washington, DC Dr and Mrs Robert E Mamer Diane and Robert Ms Penelope Hare Jaye Way/and, Massachusetts West Fa/mouth, Massachusetts Newton, Massachusetts

Walter and Shirley Massey Dr William R Dr. and Mrs. Robert Haselkorn Jeffery Atlanta, Georgia Chicago, Illinois Silver Spring, Maryland Mr and Mrs Robert Mastroianni Jones Woody and Hanna Hastings Ms Barbara W Fa/mouth, Massachusetts Cambridge, Massachusetts Fa/mouth, Massachusetts Luigi Mastroianni, M D. and R Freda and Kaminer Ph Dr Robert Haubnch Benjamin Elaine Pierson-Mastroianni, M D , D Woods Massachusetts Granville, Ohio Hole, Haverfbrd, Pennsylvania

B. and Richard S Bockman Synnova Hayes Drs Darcy Kelley Mr. Andrew Mattox and Ms Sandee Parmelee New York Princeton, West Virginia Sag Harbor, Woods Hole, Massachusetts

and Dr Diane E Heck Anastasia Tom Kelly Dr and Mrs Robert T McCluskey Rumson, New Jersey River Vale, New Jersey Brooklme, Massachusetts

Dr. and Mrs Thomas Hedges, Jr Dr and Mrs Alexander Keynan Mr and Mrs Michael Meehan Moorestown, New Jersey Jerusalem, Israel Wi//iamstown, Massachusetts

Mr and Mrs A Knowles, Jr Dons and Howard Hiatt Sidney Dr and Mrs Jerry M Melillo Cambridge, Massachusetts Raleigh, North Carolina Falmouth, Massachusetts

Mr and Mrs David Hibbitt Sir Hans and Lady Kornberg Mr Richard P Mellon Fa/mouth, Massachusetts Bristol, Rhode Island LaugMmtown, Pennsy/vanja

Ms V Korzun Dr Llewellya Hilhs and Dr Paul Colmvaux Ellyn Dr and Mrs Roger D Milkman Woods Hole, Massachusetts Chatham, New Jersey Fa/mouth, Massachusetts

Mr Timothy T Hilton Dr William J Kuhns Mr Gernsh H. Milliken Ontario Cambridge, Massachusetts Toronto, New York, New York

Gregory J and Pamela Clapp Hmkle Plymouth, Massachusetts R75

Drs M Skinner and John S Cook Ralph and Muriel Mitchell Tom and Patty Pollard Dorothy Cambridge, Massachusetts Branrbrd, Connecticut Falmoufh, Massachusetts

Dr and Mrs Merle Mizell Drs Frank and Billie Press Drs Melvm and Evelyn Spiegel New Orleans, Louisiana Washington, DC Hanover, New Hampshire

Mrs Steel Dr Leyla deToledo-Morrell Mr and Mrs John S Price Connnc York Chicago, Illinois Bryn Mawr, Pennsylvania Little Neck, New

Dr and Mrs Malcolm S Ms Marcia Morris Charlotte and Irving W Rabb Steinberg Boston, Massachusetts Cambridge, Massachusetts Princeton, New Jersey

Professor and Mrs Toshio Narahashi Lionel and Mildred Rebhun Mr and Mrs James M Stewart Nanrucket. Massachusetts Chicago, ///

Mr and Mrs Frank L Nickerson Mr and Mrs Peter W Renaghan Carol and Joseph T Stewart, Jr Fa/mouth. Massachusetts North Fa/mouth, Massachusetts Skillman. New Jersey

Mr and Mrs Richard Rhoads Mr Richard H Stowc Boston, Massachusetts New York, New York

Drs Alfred and Suacher Dr Monica Riley Dorothy Fa/mouth, Massachusetts Ros'yn, New York

Gerard and Dr and Mrs Harris Ripps Mary Swope Chicago, Illinois Washrngton, DC

Dr and Mrs Jack Rosenbluth John and Malory Swope New Rochelle. New York Concord, New Hampshire

Allan and Clare Rosenfield Andrew G and Ursula Szent-Gyorgyi Hartsda/e, New York Wa'tham, Massachusetts

Mr and Mrs Edward S Rowland Mr and Mrs Samuel Thome Harm/ton, Massachusetts Manchester, Massachusetts

Drs Joan and Gerald Ruderman Mr and Mrs Tom Tierney Massachusetts Wellesley, Massachusetts Wellesley, Andrew Hawkins Mr Andrew Sabm Mr D Thomas Trigg Massachusetts East Hampton, New York Westwood, Ronald P and Karen E O'Hanley Elaine and Walter Troll Ipswich, Massachusetts Dr and Mrs Edward D Salmon New York. New York Chapel Hill. North Caro//na David and Anastasia Palmer Mr and Mrs Edward Tsoi Waquoif. Massachusetts Dr. and Mrs Hidemi Sato Massachusetts Toba M/e, Japan Arlington, Dr and Mrs George D Pappas Walter Vincent and Dore Butler Chicago, Illinois Dr and Mrs John W Saunders, Jr Drs Woods Ho'c. Massachusetts Waquo/f, Massachusetts Drs Thoru and Judith Pederson Worcester, Massachusetts Mr Morton T Saunders Dr and Mrs Byron H Waksman New York, New York G/adwyne, Pennsylvania Mr and Mrs Joseph Pellegnno Leonard and Eve Warren Boston, Massachusetts Dr Cecily Cannan Selby Bato New York, New York Cynwyd, Pennsylvania Mrs Nancy Pendleton Mr and Mrs Wheeler Fa/mouth, Massachusetts Dr and Mrs Douglas R Shanklm Henry Massachusetts Memphis, Tennessee Boston. Bertha and Philip Person Ms Rosalind C Wh.tehead Flushing. New York Marilyn and David Sheprow York Woods Hole, Massachusetts New York, New Mr and Mrs Frederick H Pierce Mrs Annette L Williamson Amherst, New Hampshire Mrs Jacqueline N Simpkins Barnstab'e, Massachusetts Fort Worth, Texas Mr and Mrs Robert W Pierce. Jr Boston, Massachusetts Dr Matthew Wmkler Austin, Texas R76

ANNUAL FUND 2002

Gifts to the Annual Fund are unrestricted and used immediately where they will best benefit the current activities of the MBL research community.

I and Foundation Donors Corporate The Sponsors Club The Century Club $250 - $499 $1 00- $249 Aetna Inc Amengroup Foundation Dr and Mrs Daniel L Alkon Mr Thomas H Aal Bay Foundation Drs James and Helene Anderson Dr and Mrs Donald A Abt George Botelho, Inc Mr and Mrs Michael Angelini Dr Nina Stromgren Allen Mr The Commonwealth Fund Dr and Mrs George P. Baker, Jr and Mrs David S Ament Cox Foundation, Inc Dr Andrew Bass and Ms Margaret Marchaterre Mr and Mrs Duncan P Aspmwall ExxonMobil Foundation, Inc Dr Martha B Baylor Mr and Mrs Richard Asthalter Gilbane Building Company Dr Miriam F Bennett Mrs Kimball C Atwood, III The Gillette Company Mr and Mrs Thomas C Bolton Mr Nathaniel Atwood and Ms Susan Parkes Doreen Grace Fund Drs Harry Conner and Carol Scott-Conner Mr and Mrs Donald R Aukamp Harken Foundation Mr John Cromie and Dr Gloria Gallo-Cromie Dr. and Mrs David S Babm Johnson & Johnson Dr and Mrs. Paul J De Weer Mr and Mrs John M Baitsell The Henry J Kaiser Family Foundation Drs Lmda Deegan and Christopher Neill Drs Barbara-Anne Battelle and James Alligood The Gruss Lipper Foundation Prof and Mrs Frederick A Dodge Dr and Mrs Thomas L Benjamin McDonald's Corporation Mr and Mrs David Fausch Mr and Mrs Maks Birnbach National Grid Dr Rachel D Fink Dr, and Mrs. Thomas P Bleck Oracle Corporation Dr and Mrs Harold Gainer Dr and Mrs David A Bodznick The David and Lucile Packard Foundation Mrs Mary L Goldman George Botelho, Inc Josephine Bay Paul and C Michael Paul Dr Stephen L Hajduk Drs Barbara and John Boyer Foundation Dr and Mrs John P Harrington Mr and Mrs Peter Boyer Ralph F Peo Foundation, Inc Mr William A Raskins Mrs Eleanor D Bronson Saint-Gobain Corporation Foundation Mr and Mrs Gary G Hayward Ms Sarah Dixwell Brown The Schooner Foundation Mrs Elizabeth Heald Mr and Mrs Darryl A Buckingham Esther Simon Charitable Trust Dr Yukio Hiramoto Bufftree Building Co , Inc Mr and Mrs Lon Hocker Drs William and Madeline Burbanck Dr and Mrs Daniel Johnston Mrs Barbara Gates Burv/ell The 7888 Club Dr and Mrs Morns John Karnovsky Mr and Mrs William O Burwell Mr and $500 - $999 Mr and Mrs Gilbert King Mrs Bruce E Buxton Dr and Mrs Edward A Kravitz Mr and Mrs John L Callahan, Jr Dr and Mrs Alan M Kuzman Mr and Mrs David J Campbell Drs Ted Begenisich and Sherrill Spires and Mrs William K Mr and Mrs D Bret Carlson Mr and Mrs Robert O Bigelow Attorney Mackey Ms Lynn Snyder Mackler Mr Robert J. Carney Drs Colleen Cavanaugh and Philip Gschwend P Ph Drs Richard and Hermme Father D Cassidy. O , D Mr and Mrs Gorham L Cross Makman Joseph Dr and Mrs Julian B Marsh Dr and Mrs Estill L Caudill Drs Robert and Ellen DeGroof Ms Jane A McLaughlm Ms Martha Chen Dr Philip Dunham and Ms Gudrun Bjarnarson Dr DeForest Mellon, Jr Mrs Vera S Clark Mrs Ruth E Fye Drs Timothy Mitchison and Christine Field Dr Mary Clutter Dr Joseph Gall and Ms Diane Dwyer Dr Peter A N.ckerson Dr Carolyn Cohen Mr and Mrs Charles M Ganson, Jr Dr and Mrs Santo V Nicosia Dr and Mrs Maynard M Cohen Mr and Mrs William Gilbane, Jr Mr and Mrs William J Pechilis Mr and Mrs Alexander Mr and Mrs John G McMillian Colby Dr Khela Mr and Mrs Franz Colloredo-Mansfeld Mr Andrew E Norman Ransier Rev Dr. LeBaron C. Colt, Jr Mr and Mrs Jonathan O'Herron Michael Robertson and Dr Robertson Mr and Mrs Nathaniel S Dr Michael Rabinowitz and Ms Diane Hoxmeier Emmy Coolidge Mr and Mrs S Robertson Dr and Mrs Sherwm J Dr Edward B. Rastetter Phillip Cooperstem Mr Kenneth Rosenthal Dr and Mrs John O Corliss Dr and Mrs Frederick R, Rickles Dr Cynthia V Stauffacher Dr Helen M Costello Mr Michael C Ruettgers Dr Dusan Stefoski Mr and Mrs William G Prof, and Mrs Howard K Schachman Coughlin Dr Andreas C Stemmer Mr Charles Crane and Ms Wendy Breuer Mr. and Mrs Hans L Schlesmger Drs Maurice and Sussman Dr Karen Crawford Dr and Mrs William Trager Raquel Mr and Mrs E Mr and Mrs Richard D Cutler Mr and Mrs John J Valois Stephen Taylor Drs William and Telfer Dr and Mrs D'Alessio Dr Dyann an M- Peter Wirth Mary Giuseppe Mr and Mrs Richard Verney Dr and Mrs Nigel Daw Mr and Mrs. Lynn H Wilke Dr Martha Bridge Denckla Mr and Mrs Leslie J Wilson Dr Wolf-Dietrich Dettbarn Dr Charles Yanofsky Dr William A Dickson Mr John F Zietlow, Jr Mr and Mrs David L Donovan Dr Michael J Zigmond Ms Dorothy L Drummey Mr Fertilized sea urchin egg, Hakhyun Ka and Mrs Hans Zimmer R77

Annual Fund Volunteers

Chairman Dr Peter B Armstrong

Associates Chairman Mr Michael Fenlon

Volunteers Dr Robert B Barlow. Jr Dr A Verdi Farmanfarmaian Mr Homer W Lane. Jr Dr. Hans Laufer Dr Anthony Liuzzi Dr Luigi Mastroianni. Jr Dr Merle Mizell Dr Thoru Pederson Dr Robert A Prendergast Dr Cecily C Selby Dr Byron H Waksman

Annual Fund, continued

Dr and Mrs Thomas K Duncan Mr and Mrs Hoyt Ecker Elizabeth Armstrong Dr Frank Egloff Drs Paul Englund and Christine Schneyer Dr and Mrs Herman T Epstein Estabrooks Mr Gordon C Dr David Klein Mr and Mrs Brian Nickerson Dr and Mrs Thomas Evans Mr Mark Koide Mr. and Mrs Michael O'Rand Dr Alan Ezekowitz and Ms Debbie Lunder Dr and Mrs Rudolf Dr Kiyoshi Kusano Oldenbourg Dr Patricia M Failla Dr Janice and Mr Albert Olszowka Drs Eugene and Mitsuko Laforet Daniel D Federman Mr and Mrs Ms. Judith E Laster Mr James G Ottos Mr and Mrs Howard G Freeman Mr William Lawrence and Mrs Barbara Buchanan Dr and Mrs Ray D Owen Friedman A Park Dr Larry Jay Dr and Mrs John J Lee Mr Malcolm Dr John J Funkhouser H Park and Mrs Ms Alice C Leech Ms Marina B Dr and Mrs Robert M Galatzer-Levy Dr Marian E LeFevre Dr and Mrs Rodenc Park Frank B Pearce Dr and Mrs Gallagher Dr David P Lenzi Dr and Mrs John Miss Eleanor Garfield Dr and Mrs Aaron B Lerner Mr and Mrs David Pearson A Perkins Ms Margaret Geist Dr and Mrs Jack Levin Dr and Mrs Courtland D Mr and Mrs Vincent Dr Bruce J Peterson Geoffrey Dr. and Mrs Richard B Levine Dr and Mrs Martin Gibbs Drs David and Jeanette Pleasure Mr and Mrs David W Lillie Mrs Janet F. Gillette Dr Jeanne S Pomdexter Dr and Mrs Daniel M Lilly Drs Alfred and Joan and Mrs B Pollard Goldberg Dr. and Mrs Richard W. Linck Dr Harvey Dr. and Mrs Herbert Graham Drs Mary Porter and Tom Hays Dr Raymond J Lipicky Dr and Mrs Green Dr Dale Purves and Ms Shannon Ravenel Philip Dr Stephen J Lipson Mr Noah Mr and Mrs Putnam, III Greenberg Dr. and Mrs. John E Lisman George Dr L Greif Ms Kathenne E Putnam Roger Dr. Robert B Loftfield Dr and Mrs Newton H Gresser Dr and Mrs James P Quigley Dr and Mrs. Irving M London Dr June and Mr Arnold Lum Mrs Robert F Rakowski Harngan Dr Louise M Luckenbill Dr and and Mr Robert Suitor Dr Glenn W Harnngton Dr Richard Lum Dr Carol Reinisch Dr and Mrs Neils Haugaard Dr Judith Rhodes Mr Gerald Lynch Mr and Mrs Edmund Hazzard Drs Paul and Michele Lorand Drs Richard and Sylvia Manalis Rmgel K Dr and Mrs Peter Hepler Mr and Mrs Ronald Marcks Mr and Mrs John Ripple Mrs Theodore T Herskovits Rmer Dr and Dr Andrew C Mannucci Dr Hope Mr Mrs William Hobart Rodin and Mr and Mrs Lowell V Martin Mr Dana Dr Edward Horn Lawrence Rome G Dr and Mrs William M McDermott Dr and Mrs C Dr and Mrs James C Houk Dr Joel L Rosenbaum Mr Paul McGonigle Prof Nechama Lasser-Ross Ruth Hubbard Dr and Mrs David McGrath Drs William Ross and Dr and Mrs W Bruce Hunter Dr Uldis Roze Mr and Mrs James McSherry Dr and Mrs Kurt J Isselbacher William Devme Russell-Hunter Dr Martin Mendelson Dr Dr Marietta Radovic Issidorides Dr Melanie and Mr Klein Merriman Mrs Anne W Sawyer Dr Launnda A Jaffe Mrs Lilian M Dr Nancy S Milburn Scherp Mr and Mrs Ernest Jaworski Herbert Schuel G Dr and Mrs Rtcardo Miledi Dr Mrs Sally S Joslm Dr and Mrs Robert Seidler Drs David and Virginia Miller Drs Jane Kaltenbach and Robert Townsend Ms Barbara Park Mr. and Mrs Robert W Morey. Jr Shapiro Mrs Karush Mr and Mrs John J Sheridan Sally Mr and Mrs Samuel Murphy Mr and Mrs H Ernst Keller Drs Silverstem and Dr. and Mrs X J Musacchia Roy Jacquelyn Mr Louis M Kerr Dr. and Mrs John E Naugle Joseph-Silverstein Mr and Mrs Arthur F King Messrs William and David Newton Dr Maxine Singer Continued R78

Mr and Mrs Alvin Fossner RADM J Mr and Mrs Alain Singer Paul Mulloy USN (Ret) Dr Frenkel Mrs Cynthia C Smith Krystyna Ms Ins Nelson Drs Dr and Mrs. Paul F Smith Patricia Garrett and Oliver Woshmsky Ms Kathryn Paine L Dr E Gellis Mr Drs Roxanna and Ronald ; >icwitz Stephen and Mrs Nicholas Pantazis

' Mr. and Mrs James E Gifford Mr Mr David Space ar in/is David Parker, Jr Dr and Mrs Alan Mrs Barbara B Glade Dr and Mrs Charles Parmenter

1 Dr Joel S Gordon '. Dr Dr. and Mrs W I phenson Leonard M Passano " Dr Martin ! Ms Joan Mr and Mrs : ewart Gorovsky Pearlman and Dr Peter Kivy Mrs Enka A Green Ms S Dr Elijah Ste~ Ms Jasmin Bihler Joyce Pendery

, Dr Carole Dr and Drs. Alber u rd and Margaret Maurin Nancy Greep Mrs Murray E Pendleton Mr and Mrs Dr and Mrs i.^utsuyuki Sugimori Joseph Guttenplan Ronald J Pfohl Mr and Mrs Peter A Hall Mr and Mrs. E. Kent Swift, Jr Mr and Mrs Harold Pilskaln Mr and Mrs Hall Dr Margaret W Taft Robert Mr and Mrs Kenneth Poehls Drs. Bruce Telzer and Leah T Haimo Drs Clifford and Drusilla Harding Dr and Mrs Richard A Polin Mr. and Mrs W Nicholas Thorndike Dr, and Mrs Richard Bennet Harvey Dr. and Mrs Daniel A. Pollen Dr E V John F Towle, DOS Audrey Haschemeyer Mr and Mrs Abraham I Pressman Mr and Mrs William Traver Ms Elizabeth E Hathaway Mr and Mrs Gerald B Reynolds Mr Dr and Mrs David M. Travis John Hay Dr Robert V Rice Dr and Mrs Steven N Treistman Dr Teru Hayashi Dr Morris Rockstem Miss Ruth Tucker Dr David S. Hays Mr and Mrs Peter J Romano Mrs Jane M Heald Dr. and Mrs. Kenyon S Tweedell Mr Dorothy C Ryder Mr and Mrs Volker Ulbrich Dr Simone Helluy Mr and Mrs Herbert Shanker Dr and Mrs. Ivan Valiela Drs Richard and Susan Hill Dr and Mrs Gaius R Shaver Dr. and Mrs Robert B Hill Drs. Claude and Dorothy Villee Ms Kathleen Lake Shaw Mr and Mrs Samuel Vincent Mr and Mrs Gerald J Holtz Mr Richard W Shrmer Dr Dr Talbot H Waterman Linda A Hufnagel-Zackroff Dr Jeffrey D Silberman Dr Annemarie Weber Mr and Mrs Felix Inigo Mrs. Louise M Specht

Mr and Mrs Charles A Johnson Rev III Dr and Mrs George Weiffenbach and Mrs William A Spurrier, Dr Mrs Dr Gary Wessel and James E Johnson Mrs Eleanor Steinbach Mrs RoseT Wheeler Dr Harry S Kahn Dr Raymond G Stross Dr Edna S Dr and Mrs Martin Keister White Kaneshiro Mrs. Belle K Taylor Mr. and Mrs Alan K Dr Leana Dr and Mrs Roland L Wigley Karplus and Mr Joby Topper Prof Mark D Kirk Prof and Mrs Michael Drs Jonathan and Beatrice Wittenberg Tytell Dr Peter and Drs Joshua Zimmerberg and Teresa Jones Kivy Ms Joan Pearlman Mrs Alice H van Buren Mr and Mrs Paul W Knaplund Mr James Ware and Ms Sharon McCarthy Mrs Phyllis Kuffler Mr Michael S Weinstein Mr and Mrs Ted Kulesza Dr and Mrs Charles R Wyttenbach Mr and Mrs Other Ray La Ranger Mrs Marilyn J Young | Mr and Mrs Steven V Launa Mr and Mrs Kenneth H Zimble Ms Corinne Le Bovit Mrs P Zinn Mr and Mrs David C Ahearn Margery Dr and Mrs Stephen B Leighton Dr and Mrs Steven J Zottoli Mr and Mrs Scott M Allard Mr and Mrs Edwin M Libbm Mr and Mrs John J Aziz Dr. and Mrs John H. Lochhead Dr and Mrs Richard H Backus Mr and Mrs Edward Loessel Mr and Mrs Joe Barnngton Dr Irene Loewenfeld Ms Jane Berger and Mr Roger Gittmes Dr. and Mrs Frank J Ms Pauline F Blanchard Longo Ms Lena T Lord Ms Casey Bliss Mr Fred E Lux Mr and Mrs Anthony Briana Mrs Priscilla M, Mrs Jennie P Brown Makay Dr Robert P Malchow Mr and Mrs Thomas A Brown Dr Dawn Morin Manck Dr Roberto Bruzzone Mr and Mrs Joseph S Maranchie Mr and Mrs Arnold H Burrough Dr and Mrs Joe L Martinez, Jr Mr and Mrs E Brewster Buxton Mr, and Mrs Frank J Mather, III Mr. and Mrs George Cadwalader Dr Rita W Mathews Mr Arthur D Calfee Mrs Dorothea J Mautner Dr Peter Clark and Ms Ellen Barol Mrs Polly Miles Mr and Mrs James M deary Dr and Mrs Daniel G Miller Mrs Elizabeth Ann Cohen Cdr and Mrs Lloyd C Morris U5N (RET) Mr and Mrs Peter Connolly Mr and Mrs Dana S. Morse Mr and Mrs J Crandall Sterling Mr Thomas A Mulholland Mrs Marcia Donovan Dr Patricia L Dudley Dr Quan-Yang Duh and Ms Ann Comer Mrs Frances E Eastman Dr Hugh Young Elder Mrs Helen M Erickson Dr Aian Scott Fanning Mrs Ruth Alice Fitz Mr John H. Ford R79

ALUMNI RELATIONS ADVISORY BOARD ALUMNI FUND 2002

Dr. Robert B Barlow, Jr. (Physiology. 1963) SUNY Upstate Medical University

Dr. Thomas L. Benjamin (Physiology. 1959/ Neurophysiology. 1966). Harvard Medical School

Dr. Richard T. Born & Oihs to the Alumni Fund are used to meet the basic needs of (Neural Systems Behavior, 1987) Harvard Medical School MBL courses, including tuition support for students. ephen C. Cannon (Neurobiology, 1988) sity of Texas Southwestern Medical Center

Dr. Eloise E. Clark (Physiology, 1956) Ms Joan Edstrom Anonymous Bow/ing Green State University Dr Joan Abbott Ms Marcia Edwards Prof and Mrs Laurence F Abbott Dr. Manlynn E Etzler Dr. Jeffrey T. Corwin (Neurobiology, 1975) Dr William Dr and Mrs Arnold G Eversole Agnew University of Virginia, School of Medicine Drs Dianne and Thomas Allen Dr C Ronald Anderson Prof. Donald Faber Dr. Joseph T. Coyle (Neurobiology, 2001) R Dr William DeWitt Andrus, Jr Dr. and Mrs Richard Fay Harvard Medical School Drs Robert and Lynne Angerer Dr. Marta Feldmesser Dr Carolina V Arancibia Dr V Jr Cyril Fmnegan, Dr. Joseph R. Fetcho (Neural Systems & Behavior, Drs Carol Arnosti and Andreas Teste Dr Thomas R Flanagan 1984), State University of New York Dr Michael 5 Ascher Dr. Karl W Flessa Ms Christine M Foreman Dr. Elizabeth Fowler (Physiology, 1 966) Dr and Mrs Robert Barker. Jr Dr. Elizabeth Fowler and Dr James Parmentier Millennium Pharmaceutica/s Dr Edward Joseph Behrman Dr Kenneth I Freedman Dr William H Drs and Anita Freudenthal Bergstrom Hugo Dr. Leah T. Haimo (Physiology, 1974), Dr. Gerald Dr, Marvin J Fritzler Bergtrom University of California, Riverside Dr Ari Berkowitz Dr Anne E Fry Dr Emmanuel C Besa Dr. Marnie E. Halpern (Neurobiology. 1986) Mr Edward M Blumenthal Dr. Theresa Gaasterland Carnegie Institution of Washington Dr Mark Boothby Dr Paul E. Gallant Dr Richard T Born Dr. Helen W Gjessing Dr. Alexander Keynan (Physiology, 1961) Dr. and Prof James A Glazier Elayne Bornslaeger-Bednar Israel Academy of Sciences and Humanities Mr Michael Bednar Dr Joel S Gordon Dr Emil Dr. Joan Gottlieb Borysko Eiger Dr. Daniel P. Kiehart (Physiology, 1975) Dr Peter Brodfuehrer Dr Esther M Goudsmit Dufce University Medical Center Dr and Mrs Donald D Brown Dr and Mrs Eugene Grebner Dr. P Brown Dr Lewis J. Greene Harley Dr. George M, Langford (Physiology, 1972), Dr Richard R Dr Warren M Grill Burgess Dartmouth College Dr Jerome Gross Mr and Mrs Patrick J Calie Dr William M. McDermott (Invertebrate Zoology. Dr David Dr Mamie E Campbell Halpern 1950), U.S. Navy (retired) Dr James R Campi Dr Lisa M Halvorson T. Joiner Ph D Dr Cadet Hammond Hand, Jr Cartwnght. Jr, Dr. Melanie Pratt Merriman (Embryology, 1975/ Dr Clarissa M. Dr. Susan M Cheney Harding Physiology, 1976), Touchstone Consulting Dr Jonathan Chernoff Dr. Robert D Harvey Dr Chi-Bin Chien Dr. Norman B Hecht Dr. Thomas D. Pollard (Physiology, Director 1989- Dr Carson C Chow Dr. Heitman Joseph 1 993), Yale University Dr Ka Hou Chu Drs. Joseph and Barbara Hichar Dr Carl Clark Dr W Holton Cyrus Raymond Dr Joshua R. Sanes (Neurobiology, 1971) Dr. William T Clusin Dr and Mrs Holtzman Seymour Washington University Medical Center Dr and Mrs R John Collier Mr Timothy E Holy Dr and Mrs Marc D Coltrera Dr Xudong Huang Dr. Wise Young (Neurobiology, 1972) Dr Clark E. Corliss Drs Deborah Hursh and Mark Mortin Rutgers University Dr Jeffrey T Corwin Dr Jerard Hurwitz Mr John Cromie and Dr Gloria Gallo-Cromie Dr Dr Alice M Curry Richard Intres Ex-Officio Dr Allen Isaacson Dr. C Dahl Dr and Mrs K Stephen Stephen Itaya Dr Peter B. Armstrong (Invertebrate Zoology, 1961) Dr and Mrs Harry W Dickerson Chairman, MBL Annua!/Alumni Fund Dr William J Dickinson Dr. Jon W Jacklet University of California, Davis Dr Bruce A Diner Dr Nancy A Johnson Mr. Jonathan S and Dr Thelma Dixon Dr Leslie and Mr James Jolly Dr. John E. Dowling (Neurobiology, 1970) Mr and Mrs Richard Drucker President. MBL Corporation Dr Catherine Asleson Dundon Harvard University Dr Kathleen Dunlap Dr and Mrs David Durica Continued R80

Students get dockside instruction from Marine Resources

Center staff, Elizabeth Armstrong

Dr Dana T Dr. and Mrs James W Kalat Nojima Dr Joel P Stafstrom Mrs Norris Or Mananna M Kane Phyllis Dr Gary R Strichartz Drs Victor and Ruth Nussenzweig Dr Alvm M. Kaye Dr David T Sullivan J Or Gordon I Kaye Dr Frank Swartz Dr Michael D. Oberdorfer Drs Thomas and Laura Keller Ms Hyla C Sweet Dr Catherine L Olsen Dr and Mrs R Emmett Kenney Dr. Ben G Szaro Dr Olsen Dr Richard G Kessel Ingnth Deyrup Prof. John M. Olson Dr Lynda A Kiefer Ms Penny A Tavormma Dr and Mrs Brett A Oxberry Dr Elizabeth L Kimberly Mrs Vera A Taylor Dr Donald W King Dr Saul Teichberg Mrs G. Pacifici Dr Leonard B- Kirschner Mary Dr Wesley J Thompson Drs Paul and Charles Thomas Dr and Mrs Paul M Knopf Kimberly Dr Barbara Holland Toomey Mr Matthew Person and Ms Jill Enckson Dr Robert E Knowlton Dr Norman J Pieniazek Dr Carol A Koenigsberger Dr Jeanine A Ursitti Dr Louis Pierro Dr WieslawJ Kozek Dr Carl B PNcher Dr Ajit Kumar Dr Raghunath Virkar Dr Pires and Mrs Anthony Ms Melissa A Vollrath Dr Sabrina and Mr Bradford Powell Dr Michael J Landzberg Dr Susan Volman Dr Holly A Lavoie Dr Esther L Racoosm Dr Matthew K Lee Dr William G Wadsworth Dr Jennifer L Dr William J Lehman Raymond Dr Brant G Wang Dr Jean and Mr Ronald Dr Ellen K. LeMosy Regal Dr Deborah Williams Ward Dr and Mrs Robert Alan Resnik Dr Ethan Lerner Drs Gary E Ward and Zail Berry Dr Kristin Lester Revill Drs Brian Link and Vivian Lee Mr and Mrs Herman Ward Dr. Randall W Ms Anne M Linton Reyer Dr and Mrs Samuel Ward Ms Marian C Rice Drs Joan and James Lisak Dr Susanna H Weerth Dr Austen F Mr and Mrs Edward K Lobenhofer Riggs Ms Kay E Wellik Dr M Robbins Dr and Mrs Robert J Loeffler Regma Dr Harold Bancroft White Drs Duncan and Grace Saunders Rollason Dr Ann M Lohof Dr Clayton Wiley Brian K Romias, MS Dr Jane Lubchenco MD, Dr Ulrike Wille T Dr James Russell Dr Kathenne Wilson Ms Carol Ann Dr Stephen E Malawista Ryder Dr Andrea G Witlin Dr David E Mann, Jr Dr Anne M Wood R Dr Dr. David Samols Drs Lawrence and Judith and Mrs. Phillip 6 Maples Wysocki Spiegel Dr Satoh Dr Junko Munakata Marr Noriyuki Dr Richard L Saunders Dr Michael Massanan Dr Ayako Yamaguchi Dr Charles H Dr. Jon M McCormick Sawyer Dr Naoyuki Yamamoto Dr RolfSchauder Dr Duane P. McPherson Ms Judith L Yanowitz Dr. Paul R. Schloerb Dr Anne Messer Dr. Karen P York Dr H Schwartz Dr Laurie Miller James Dr Lin Yue Dr Carla Shatz Dr Maria I Morasso Dr and Mrs Alan Sher Dr Yasuhiro Morita Dr and Mrs Cheng Zhu Dr David R Sherwood Mr Stephen h Munroe Dr Richard E Zigmond Dr Joyce M Simpson Dr Max Snodderly Dr David P Nagle, Jr Dr Sandra C Souza Drs Angus Nairn and Marina Picciotto Dr Lee Niswander Mr Nelson Spruston R81

FELLOWSHIPS AND SCHOLARSHIPS

Endowed and expendable funds for scholarships and fellowships are an integral part of the MBL's successful research and education programs. In 2002, twenty-two scientists from the U.S. and abroad were awarded fellowship grants that allowed them to work in our uniquely collaborative research environment. The Laboratory also awarded scholarships to 97 highly qualified students, enabling them to participate in our total-immersion courses.

We gratefully acknowledge the donors listed below, who provided $245,270 for research fellowships and $726,558 for scholarships in 2002.

American of Cell Society Biology I Aline D. Gross Scholarship Fund Summer Research Awards Dr and Mrs Paul R Gross American Society of Cell Biology Dr and Mrs Benjamin Kaminer Dr and Mrs Lewis P Rowland

I Robert Day Allen Fellowship Fund Technic, Inc Drs. Joseph and Jean Sanger

I E. E- Just Endowed Research Fellowship Fund

I MBL Associates Endowed Scholarship Fund The Cole Memorial Family Fund MBL Associates William Townsend Porter Foundation

Mrs. Nawne Meigs-Brown Georgia-Pacific Corporation

I B. Frederik Bang Fellowship Fund I Fred Karush Endowed Library Readership Dr and Mrs Jack Levin Dr and Mrs Laszlo Lorand Dr and Mrs Arthur M Silverstein

I Charles R. Crane Fellowship Fund Fund Friendship I H Keffer Hartline Fellowship Fund Dr. Peter Hartline

I John O. Crane Fellowship Fund Mr and Mrs Frederick F Hartline Friendship Fund Dr and Mrs Thomas R Hedges, Jr Ms Rebecca Kucera

I Jean and Katsuma Dan Fellowship Fund Dr Earl Weidner Mr William A Haskms Mrs Eleanor Steinbach I Kuffler Fellowship Fund Drs Joseph and Jean Sanger Dr and Mrs Edward A Kravitz

Bernard Davis Fund Frank R. Lillie | and Fellowship | Fellowship Scholarship Mrs Elizabeth M Davis Estate of Emily Ann Cramer

I S. T. Daniel and Edith Grosch Scholarship Fund I Mountain Memorial Fund Ms Laura Grosch and Mr Herb Jackson Dr and Mrs Dean C Allard. Jr Ms Brenda J Bodian Mr and Mrs Amos L Roberts Mr and Mrs Thomas H Roberts

Mouse oocyte, Umit Ali Kayisli Continued R82

James A and Faith Miller Fellowship Fund I The Catherine Filene Shouse SES Scholarship Fund Drs David and Virginia Miller The Catherine Filene Shouse Foundation

Frank Morrell Endowed Memorial Scholarship (The Catherine Filene Shouse Scholarship Fund Dr Leyla de Toledo Morrell The Catherine Filene Shouse Foundation

Hartshorne Mudd Fund The Catherine Filene Shouse Fund | | Emily Scholarship Fellowship World Academy of Art and Science The Catherine Filene Shouse Foundation

I Neural and Behavior Fund The Gruss Fund Systems Scholarship | Upper Dr and Mrs Alan Gelpenn The Gruss Upper Foundation Dr Warren M Gnll

Drs William Knstan and Kathleen French i The Bill and Phoebe Speck Fund Dr and Mrs Richard B Levine Dr William T Speck Dr Mark W Miller Drs. Jams C Weeks and William M Roberts The Evelyn and Melvm Spiegel Fellowship Fund | Drs Harold Zakon and M Lynne McAnetly Dr and Mrs Jack Levin Ms M Jade Zee The Sprague Foundation Drs Joseph and Jean Sanger Nikon Fellowship

Nikon Instruments Inc I H. B. Stembach Fellowship Fund Mrs Eleanor Stembach The Plum Foundation John E. Dowlmg Fellowship Fund Horace W Stunkard Scholarship Fund | The Plum Foundation Drs Albert Stunkard and Margaret Maunn

I William Townsend Porter Fund Eva Fund Scholarship | Szent-Gyorgyi Scholarship ' for Minority Students Dr and Mrs Benjamin Kammer William Townsend Porter Foundation Dr and Mrs Laszlo Lorand Drs Joseph and Jean Sanger

I Florence C Rose and S. Meryl Rose Endowed Dr Andrew and Ms Ursula Szent-Gyorgyi I Scholarship Fund

Dr Gwynn Akin Bowers I Universal Imaging Fellowship Fund Dr and Mrs D Eugene Copeland Universal Imaging Corporation Mrs Edna B Hill

Ms Kaaren Janssen Walter L. Wilson Endowed | Scholarship Dr and Mrs Benjamin Kammer Dr Paul N Chervm W K Kellogg Foundation Dr Jean R Wilson Dr Hans Laufer Dr Liuzzi and Mrs Anthony I Young Scholars/Fellows Program Dr and Mrs Roger D Milkman Drs James and Helene Anderson Mrs Eleanor M, Nace Drs Harry Conner and Carol Scott-Conner Drs Keen A and Nancy S. Rafferty Or and Mrs James L German Mrs Florence C Rose Dr and Mrs Anthony LIUZZI Mouse cell tnvas'cn pores Dr and Mrs John W Saunders. Jr Drs and Elaine Mastroianm and membrane, mouse Luigi Dr and Mrs J P Trrnkaus Drs David and Miriam Mauzerall b'astosist, Umit Ali Kayislt Drs Matthew and Jeanne Meselson Milton L Shifman Endowed Drs Skinner and John Cook | Scholarship Dorothy Milton L Shifman Scholarship Trust Dr and Mrs Edward A Spiegel Dr Annemarie Weber Drs Jonathan and Beatrice Wittenberg Mr and Mrs Kenneth H Zimble R83

MEMORIAL AND TRIBUTE GIFTS

The following donors have chosen to support the Marine Biological Laboratory as a special way to remember or honor a relative or friend.

In of John Helfnch | Memory Drs. Colleen Cavanaugh and Philip Gschwend Drs Bruce and Teresa Corliss Harken Foundation Ms Ken Holland Dr Max Holmes

Drs Knute Nadelhoffer and Barbara Billings Ms Andrea Ricca Dr and Mrs Gaius R Shaver

Mr Jeffrey Shelkey and Ms Joanne Willey Ms Jane Tucker Dr. and Mrs Lawrence J Wangh Dr Xiangming Xiao

In of Mr. Robert Huettner | Memory Mrs Carmela J Huertner Mr and Mrs Richard A Huettner Ms Catherine N Norton

In of Dr. Arthur G. Humes | Memory Dr Patricia L Dudley

In Honor of Lawrence | Macy Dr and Mrs Gerald Weissmann

In of Dr. Frank Morrell | Memory Dr Thomas P. Bleck Honor of Drs. and Clara |ln Clay Armstrong Bequests In Honor of Ms Lynn Snyder Mackler | Cooper Neely Mr and Mrs Joe Barnngton Estate of Emily Ann Cramer In of Dr. Kimball C. III | Memory Atwood, In of Dr. Lionel I. Rebhun Mrs Eleanor Steinbach | Memory Estate of Madelene E Pierce Drs Robert and Anne Goldman

In of Dr. Frank A. Jr. | Memory Brown, In of Elizabeth Russell P. (Tibby) Mrs Jennie Brown | Memory Dr and Mrs Ray D Owen In of Dr. Francis D. Carlson | Memory In Honor of Salmon Mrs Carolyn S. Carlson | Marjone Drs David Forkosh and Linda Hirshman

In Honor of Mr. Richard D. Cutler | In Honor of Mr. Arthur D. Traub Gilbane Building Company | Ms Natalie Miller

|ln Memory of Eugene Floyd DuBois In of Dr. E Wheeler Mrs James R Glazebrook | Memory George Dr Khela Ransier Mrs T In of Dr. D. Ebert Rose Wheeler | Memory and Mrs. James Dr and Mrs Charles R Wyttenbach In of Dr Charles G. Wilber | Memory In Mrs Clare M Wilber I Memory of Morris Goldman Dr and Mrs Harris Ripps In Honor of Alfred and Zeien | Joyce Mr Michael In of Elizabeth K. Hartline C Ruettgers | Memory Dr and Mrs Thomas R Hedges, Jr R84

OTHER GIFTS AND PROGRAMS

of the MBL educational is maintained The quality and success program and through the loan of research equipment, reagents, computers by:

Equipment Lenders Elizabeth Armstrong

PCS Assembly Accelrys Inc General Valve Corporation Peak Performance Inc Adams & List Associates Genetronics, Inc / BTX Instrument Technologies. Genomic Solutions Perkm Elmer Applied Biosystems Agilent Technologies. Inc. Division Elmer Life Sciences Amersham Pharmacia Biotech Inc GlaxoSmithKlme Perkm Photon International A.M P.I Grass Instrument Company/ Technology Photonic Instruments Apogent Discoveries/ Robbins Astro-Med, Inc GrassTelefactor Platform Inc Matching Gifts Scientific Computing Photonic Promega Corporation Applied Precision, Inc Hamamatsu Systems Inc Aquatic Eco-Systems. Inc Harvard Apparatus, Aetna Inc Quantitative Imaging Corporation Aquatic Habitats BP Foundation, Inc Arcturus Engineering, Inc Improvision Inc The Fund Research Precision Instruments, Co Commonwealth Atto Bioscience Instrutech Corporation ExxonMobil Foundation, Inc Inc Roche Science AutoQua,nt Imaging, Inc Intelligent Imaging Innovations, Applied Johnson & Johnson Scientific Axon Instruments, Inc Invitrogen Roper The Henry J Kaiser Family Foundation San Instruments Barnstead/Thermolyne Jackson ImmunoResearch Diego K Foundation Cruz W Kellogg Beckman Coulter Instruments. Inc Laboratories, Inc Santa Biotechnology McDonald's Corporation Becton Dickinson IS Scanalytics National Grid Scion Biocare Medical Kepco Power Co Corporation Oracle Instruments Corporation BD Biosciences Kinetic Systems, Inc SD The David & Lucile Packard Zonen/Division of SCI-TEC Biophotonics international Kipp & Sigma Foundation Stnauer Associates, Inc Bioptechs Instalments, Inc Instruments Saint-Gobain Corporation Bio-Rad Confocat Soma Scientific Medical Foundation Bio-Rad Laboratories Lab Line SONY Systems Bnnkmann Instruments Laser Science Stoelting Instrument Brownlee Precision Co Leica Confocal Sutler Company Inc Synaptosoft, Inc Burleigh Instruments, Inc Leica Microsystems Ludl Electronic Products, Ltd Cairn Research LTD Ludlum Measurements, Inc Technical Manufacturing Cambridge Electronic Design Corporation The of Ltd Cambridge Research MatTek Corporation Company Biologists, Instrumentation, Inc McCrone Microscopes ThermoElectron ThermolEC CBS Scientific Company, Inc Micro Video Instruments, Inc ThermoNeslab Chroma Technology Corporation Microway ThermoSavant Coherent Inc Miltenyi Biotec, Inc ThermoShandon COMPAC Computer Corporation MJ Research Molecular ThermoSpectronics Compix Inc . Imaging Systems Dynamics Crest Technologies Molecular Probes Universal Imaging Corporation CyBio, Inc MWG Biotech

Vashaw Scientific Dagan Corporation Nanodrop Technologies Vibratome Dako Corporation Nanshige USA, Inc Vincent Associates David Kopf Instruments National Instruments Del Imaging Systems, LLC Nikon Confocal VWR Diagnostic Instruments, Inc Nikon. Inc Warner Instrument Corporation DNA Star, Inc World Precision Instalments DVC Co Inc Olympus Confocal Olympus Corporation Carl Zeiss, Inc Eastman Kodak Omega Optical, Inc Instrument Co Carl Zeiss Confocal Edinburgh Biocomputing Systems Ophthalmic Carl Zeiss Imaging Eppendorf Scientific Inc. Optiquip Optronics FHC Fine Science Tools Fisher Scientific/Zylux Corp. Fluke Corporation R85 governance & administration

BOARD OF TRUSTEES

Chairman of the Board of Trustees I Ex Officio Trustees Sheldon J Segal, The Population Council

William T Director and Vice Chair of the Board of Trustees Speck, Chief Executive Officer Robert E Palazzo, Chair of the Science George W Logan. Pine Street Partners Council Mary B Conrad, Fiduciary Trust International President of the Corporation John E Dowlmg, Harvard University Executive Committee Director and Chief Executive Officer of the Board of Trustees William T Speck, Marine Biological Laboratory* Margaret C Bowles Treasurer of the Corporation Mary B Conrad' Mary B Conrad. Fiduciary Trust International" George W Logan Marcia Morris Clerk of the Corporation, Ronald P O'Hanley Thomas S Robert E Crane. Mintz. Levin. Cohn. Ferris, Glovsky & Palazzo' Popeo, PC* Sheldon J Segal William T Speck- Chair of the Science Council Chnstopher M Weld Robert E Palazzo, Rensselaer Polytechnic Institute'

Class Trustees | of 2003 Honorary | Brisbane Darcy Kelley. Columbia University William T Laurie J Landeau, Marmetics, Inc Golden. New York. NY Robert E Burton J Lee, III. Vero Beach. FL Mainer, Wayland, MA Ronald P O'Hanley, Mellon Institutional Asset Mgt Jean Pierce, Boca Grande. FL Vincent J Schooner LLC Trustees Emeriti Ryan. Capital |

Edward A \Classof2004 Adelberg, Yale University. New Haven. CT M Howard Jacobson, Bankers Trust John B Buck, Sykesville, MD S George M Langford, Dartmouth College Seymour Cohen, Woods Hole, MA G William Miller, G William Arthur L Colwm. FL Miller & Co . Inc Key Biscayne. Frank Laura Hunter Colwm, Press, The Washington Advisory Group Key Biscayne. FL Donald Christopher M Weld, Sullivan and Worcester. Boston Eugene Copeland, Woods Hole, MA Torsten N Sears Crowell, Jr. Indiana Wiesel. The Rockefeller University University. Bloomington, IN Teru Hayashi. Woods Hole. MA Class of 2005 Ruth Hubbard, Cambridge. MA | C Ladd Porter Prosser, University of Illinois. Urbana, IL W Anderson. Key Largo. FL W D Russell-Hunter. Claire M Fraser, The Institute for Genomic Research Syracuse University. Syracuse. NY John W Saunders. MA George W Logan. Salem, VA Waquoit. David Sheprow. Boston, MA Robert Prendergast, Falmouth, MA D Thomas John W Rowe, Aetna U S Healthcare Tngg Wellesley, MA Walter S Vincent. Woods Hole. MA Class of 2006 | Margaret C Bowles, Woods Hole, MA iDirectors Emeriti Martha W Cox, Hobe Sound, FL Walter E Massey, Morehouse College Paul Gross. Falmouth, MA Marcia C Morris, Boston, MA Harlyn O Halvorson. Woods Hole. MA Gerald Weissmann. New York University School of Medicine

'Ex officio

As of April I 2002 R86

STANDING COMMITTEES STRATEGIC PLANNING COMMITTEES

Committee Committee | Steering Development | Christopher Weld, Chair Porter W Anderson Peter Armstrong Robert Barlow Mardi Bowles Martha Cox John Dowling Claire Fraser M Howard Jacobson Burton Lee G William Miller Jean Pierce Robert Prendergast John W Rowe Torsten Wiesel

Facilities & Capital Equipment Committee Mardi Bowles, Chair Porter Anderson George Langford Walter Massey Andrew McArthur Frank Press Christopher Weld

Committee | Nominating John W. Rowe, Chair Martha Cox 'John E Dowling, President of the Corporation Claire Fraser 'Robert Palazzo, Science Council Chair Jean Pierce Vincent J Ryan William T Speck, Director & CEO Gerry Weissmann

Finance | Committee Ronald P O'Hanley, Chair Mary B Conrad Thomas S Crane Maynard Goldman M Howard Jacobson

Darcy Kelley Laurie Landeau George W Logan Robert Prendergast

Investment Committee I Mary B Conrad. Chair Thomas S Crane George W Logan G William Miller Marcia Morris Ronald O'Hanley Vincent J Ryan R87

CORPORATION

I Life Members

Dr Edward A New Haven, CT Adelberg, Dr Herbert Levitan, National Science Foundation Dr Stockholm Bjorn Afzelius. University Dr John H Lochhead, London, England Dr Ernest Amatniek, (address unknown) Dr Birgit Rose Loewenstein, Falmouth, MA Dr John M Arnold, Falmouth, MA Dr Frank A Loewus, Washington State University Dr Robert B Loftfield, University of New Mexico Mrs G Woods Hole, MA Betsy Bang, Dr Laszlo Lorand, Northwestern University York Dr Alan W Bernheimer, New University Medical School Medical Center Dr M IL Lloyd Bertholf, Bloomington, Dr Robert E Mainer, The Boston Company, Inc Dr Herman F Bosch, Falmouth, MA Dr Julian B Marsh, Chestnut Hill, MA of Health Dr F J- Jr , National Institutes Brmley, Mr Lowell V Martin, Woods Hole, MA Dr John B MD Buck, Sykesville, Dr Rita W Mathews, Southfield, MA Dr Madeline P Burbanck, Atlanta, GA Dr, Jams Metuzals, Ontario, Canada Dr William D Burbanck, Atlanta, GA Dr. John A Moore, University of California (deceased 2002) Dr Alfred B Chaet, Maitland, FL Dr. John W Moore, Duke University Medical Dr Arnold M Clark, Woods Hole, MA Center James M Palm Beach, FL Mr Clark, Dr Aron A Moscona, New York, NY Dr M Cohen, Rush Medical Maynard College Dr X J Musacchia, Bella Vista, AR Dr S Cohen, Woods Hole, MA Seymour Dr Maimon Nasatir, Ojai, CA Dr Jack R Collier, Effie, LA

Dr McCann Collier, Effie, LA Marjone Dr Leonard M Passano, University of Wisconsin Dr Arthur L Colwin, FL Key Biscayne, Dr. William T W Potts, University of Lancaster Dr Laura Hunter Colwin, FL Key Biscayne, Dr Carl A Price, Falmouth, MA Dr Sherwin J University of Cooperstein, Dr Margaret McDonald Prytz (address unknown) Connecticut Dr Woods Hole, MA D Eugene Copeland, Dr Charles E Renn (address unknown) Dr John O Corliss, Bala PA Cynwyd, Dr George T Reynolds, Princeton University Dr Helen M. Costello, Hill, NC Chapel Dr Robert V Rice, Falmouth, MA Dr Helen NC Crouse, Hayesville, Dr Morris Rockstem, Coral Gables, FL Dr Raphael R Ronkin, Washington, DC Dr W Daw, Branford, CT Nigel Dr John D Roslansky, Woods Hole, MA Dr Robert L School DeHaan, Emory University (deceased 2003) of Medicine Dr Priscilla F Roslansky, Associates of Dr Patncia L WA Dudley, Seattle, Cape Cod, Inc. Dr Jay S Roth, Woods Hole, MA Dr Charles Edwards, Longboat Key, FL Dr Gerald F The Elliott, Open University Dr Hidemi Sato, Nagoya University Research Unit Dr R Walter Schlesmger, North Falmouth, MA Dr. Allan C Scott, Colby College Dr Patricia M Johns SC Failla, Island, Dr Arthur M Silverstein, Johns Hopkins Dr Donald T Frazier, University of Kentucky University Medical Center Dr Raymond A Sjodin, Baltimore, MD Dr. Paul F. Smith, Woods Hole, MA Dr Mordecai L Gabriel, College Brooklyn Mr John W Speer, Portsmouth, Rl Dr Glusman, New York State Murray Dr Nicholas Sperelakis, University of Cincinnati Institute Psychiatric Dr Evelyn Spiegel, Dartmouth College Dr Herbert Graham, Woods Hole, MA Dr Melvm Spiegel, Dartmouth College Dr Graver C Stephens, University of California Dr Howard L of Hamilton, University Virginia Mrs Jane Lazarow Stetten, Chevy Chase, MD Dr. Clifford V MA Harding, Jr, Falmouth, Dr Bernard L Strehler, CA MA Laguna Niguel, Dr Audrey E V Haschemeyer, Woods Hole, Dr Maurice Sussman, Falmouth, MA Dr Teru Woods Hole, MA Hayashi, Dr Raquel B Sussman, Marine Biological Dr Frederick L Hisaw, McMinnville, OR Laboratory Dr. Francis C G Canton, MA Hoskin, Mrs Gwen P Szent-Gyorgyi, Woods Hole, MA Prof Ruth Hubbard, Harvard University Dr Bruce NH W Hunter, Peterborough, Mr W Nicholas Thorndike, Wellington Stratton VA Medical Center Dr Charles Hurwitz, Management Company Dr William Trager, The Rockefeller University Dr FL George Katz, Sarasota, Dr J P Tnnkaus, Yale University (deceased 2003) Dr John M Kingsbury, Cornell University Dr Kiyoshi Kusano, National Institutes of Health School Dr Claude A Villee, Jr , Harvard Medical Dr Walter S Vincent, Woods Hole, MA Mr Ezra Laderman, Yale University Dr Paul H LaMarche, Eastern Maine Medical Dr Talbot H Waterman, Yale University Center Dr Roland L Wigley, Woods Hole, MA Dr Max A Lauffer, Penn State University Dr Lon A Wilkens, University of Missouri Medical Center Dr Paul Witkovsky, NYU Medical Center RSS

Members

Dr Donald A Abt, Univer;ity of Pennsylvania Dr Barbara C Boyer, Union College Dr Karen Crawford, St Mary's College School of Veterinary Medicine Dr. Bruce P Brandhorst, Simon Fraser University of Maryland Dr James A Adams. Tallai assee, FL Dr Marianne Bronner-Fraser, California Institute Dr Gertrud Cremer-Bartels, Muenster, Germany Dr William J A. .-?i'iian. Jr. Falmouth, MA of Technology Dr Terry J Crow, University of Texas Dr Daniel L Alkon, Rockefeller Neuroscience Dr Stephen C Brown, SUNY at Albany Medical School Institute Mr William L Brown, Weston, MA Mr Robert J Crowther, Shriners Hospitals Dr. Garland E Allen, Washington University Dr. Carole L Browne, Wake Forest University for Children Dr Nina Stromgren Allen, North Carolina School of Medicine Dr Michael P Cummings, Marine Biological State University Dr Robert A Browne, Wake Forest University Laboratory Dr Mark C Alhegro, Louisiana State University Dr Anne C Bucklin, University of New Mr Richard D Cutler, Marine Biological Medical Center Hampshire Laboratory School Dr Everett Anderson, Harvard Medical Dr Max M Burger, Novartis International AG Dr John M Anderson, Ithaca, NY Dr David R Burgess, Boston College Dr Eric H Davidson, California Institute Dr Porter W Anderson, Jr, Key Largo, FL Dr Mario H Burgos, IHEM Medical School of Technology Dr Christine Armett-Kibel, University of Dr John E Burns, Beloit College Dr Daniel B Davison, Bristol-Myers Squibb PRI Massachusetts, Boston Dr. Harold L Burstyn, Syracuse University Dr EliezarA Dawidowicz, Marine Biological of Prof Clay M Armstrong, University Dr Sherry Burszta|n, Dartmouth Medical School Laboratory Pennsylvania School of Medicine Dr Paul J De Weer, University of Pennsylvania Prosser MA Mrs Ellen Armstrong, Woods Hole, Dr Ronald L Calabrese, Emory University Dr Linda A Deegan, Marine Biological Dr Peter B Armstrong, University of California Dr. R Andrew Cameron, California Institute Laboratory Mr Robert W Ashton, Bay Foundation of Technology Dr Robert C DeGroof, Doylestown, PA Dr Jelle Atema, Boston University Marine Mr Richard H Campbell, Bang-Campbell Dr Martha Bridge Denckla, Johns Program Associates Hopkins University Jr Dr Graciela C Candelas, University of Dr Henry A DePhillips, , Trinity College Dr Baccio Baccetti, University of Sienna, Italy Puerto Rico Dr Douglas W DeSimone, University of Virginia Dr Robert G Baker, New York University Dr Lucio Canello, Stazione Zoologica "A Dr Wolf-Dietrich Dettbarn, Nashville, TN Medical Center Dohrn," Italy Dr. Vincent E Dionne, Boston University Marine Dr David Baltimore, California Institute Dr Catherine Emily Carr, University of Maryland Program of Technology Prof James F Case, University of California Dr John E Dowling, Harvard University Dr. Robert B Barlow, Jr, SUNY Ph Dr Arthur Brooks John B, Pierce Upstate Father Joseph D Cassidy, O P, D , DuBois, Medical University Providence College Foundation Laboratory T Dr Daniel Barry, South Hadley, MA Dr Colleen M Cavanaugh, Harvard University Dr Thomas K Duncan, Nichols College Dr. R Susan Barry, Mount Holyoke College Dr Edward L Chambers, University of Miami Dr Philip B Dunham, Syracuse University Dr Andrew H Bass, Cornell University School of Medicine Dr Paul V Dunlap, University of Michigan of Florida Dr. Barbara-Anne Battelle, University Dr Donald C Chang, Hong Kong University of Mr Frederick Bay, Bay Foundation Science and Technology Dr William R Eckberg, Howard University Dr. Elaine L Brown Bearer, University Dr Richard L Chappell, Hunter College Dr Kenneth T Edds, Bayer Diagnostics Dr. John M. Beatty, University of Minnesota Dr Frank M Child, Woods Hole, MA Dr Howard A Eder, Albert Einstein College Dr. Luis Alberto Beauge, Institute de Dr Rex Leslie Chisholm, Northwestern University of Medicine Investigacion Medica, Argentina Dr Elena Citkowitz, Hospital of St Raphael Ms Joan Edstrom, Falmouth, MA of Rochester Dr. Ted Begenisich, University Dr David E Clapham, Children's Hospital Dr Barbara E. Ehrlich, Yale University Dr. David A Begg, University of Alberta, Canada Dr Eloise E Clark, Bowling Green Dr Arthur Z Eisen, Washington University TEI Biosciences Inc Dr. Eugene Bell, State University Dr Herman N Eisen, Massachusetts Institute School Dr. Thomas L Benjamin, Harvard Medical Mr Hays Clark, Hobe Sound, FL of Technology Dr. Michael V L Albert Einstein Bennett, College Prof Walhs H Clark, Jr., Madison, ME Dr Hugh Young Elder, University of Glasgow, of Medicine Dr John R Clay, National Institutes of Health Scotland F Dr Miriam Bennett, Colby College Dr Alexander W Clowes, University of Dr. Paul T. Englund, Johns Hopkins Dr. R Suzanne Bennett, Albert Einstein College Washington Medical School of Medicine Dr Jewel Plummer Cobb, California Dr David Epel, Stanford University Dr. T Suzanne Berlin, York, ME State University Dr. Herman T. Epstein, Woods Hole, MA Columbia Venture Mr Norman Bernstein, Realty Dr Carolyn Cohen, Brandeis University Mr Ray L Epstein, Taunton, MA Dr Francisco Bezanilla, Health Science Center Dr Lawrence B Cohen, Yale University School Dr. John D Biggers, Harvard Medical School of Medicine Prof Donald Faber, Albert Einstein College Dr. Stephen H Bishop, Ames, IA Dr William D Cohen, Hunter College of Medicine Dr Dieter Blennemann, Riverside, CT Dr Annette W Coleman, Brown University Dr David H Farb, Boston University School Dr George S Bloom, University of Texas Dr Paul Colmvaux, Marine Biological Laboratory of Medicine Southwestern Medical Center Dr R John Collier, Harvard Medical School Dr A Verdi Farmanfarmaian, Rutgers University Dr Kerry S Bloom, University of North Carolina Dr James P Collins, Arizona State University Dr Barry William Festoff, VA Medical Center Dr. David A Bodznick, Wesleyan University Dr D. Wesley Corson, Jr, Storm Eye Institute Dr Rachel D Fink, Mount Holyoke College Dr Edward VT G Boettiger, Rochester, Dr Jeffrey T Corwm, University of Virginia, Dr Alan Finkelstem, Albert Einstein College Dr Richard A Boolootian, Sherman Oaks, CA School of Medicine of Medicine

Dr. Thomas A Borgese, Lehman College, CUNY Dr Ernest F Couch, Texas Christian University Dr Gerald D Fischbach, Columbia University Dr David Illinois State W Borst, Jr, University Dr Rachel Llanelly Cox, Marine Biological Dr Harvey M. Fishman, University of Texas Dr. Francis P. Bowles. Marine Biological Laboratory Medical Branch S Mr Dennis New York, NY Laboratory Thomas Crane, Esq , Mintz, Levin, Cohn, Flanagan, Ferns, Glovsky & Popeo, P C R89

Dr Richard Allen Franklin Mr Robert Fluck, and A Gunning, Falmouth, MA Dr Robert D. Hunter, Oakland University Marshall Dr Francis College G. Gwilham, Reed College Dr Hugh E Huxley, Brandeis University Dr Kenneth H Foreman, Marine Biological T Laboratory Prof Leah Haimo, University of California Dr Joseph llan, Case Western Reserve Dr L. Thomas O Fox, Harvard Medical School Dr Stephen Hajduk, Marine Biological University Dr Clara Franzim-Armstrong, University of Laboratory Dr Nicholas A Ingoglia, New Jersey Pennsylvania Dr Linda M Hall, Functional Insect Genomics Medical School Dr Scott California Institute Institute Fraser, Dr Saduyki Inoue, McGill University, Canada of Technology Dr Tatsuji Haneji, The University of Dr Shinya Inoue, Marine Biological Laboratory Dr. Kathleen A French, University of California. Tokushima, Japan Dr KurtJ Isselbacher, Massachusetts General San Dr T Diego Roger Hanlon, Marine Biological Hospital Cancer Center Dr Robert J French, University of Calgary Laboratory Dr Marietta Radovic Issidondes, Theodor Dr Chandler M Fulton, Brandeis University Dr Ferenc Harosi, New College of the Theohan Cozzika Foundation

Dr - Barbara C Fune, Beth Israel Deaconess University of South Florida Dr Colin S Izzard, SUNY Albany Medical Center F Ph June Harngan, D , Honolulu, HI Dr Bruce P - Fune, Beth Israel Deaconess Dr John Harrington, SUNY New Paltz Dr Laurmda A Jaffe, University of Connecticut Medical Center Dr Stephen C. Harrison, Harvard University Health Center Dr Edwin J Dr Robert Furshpan, Harvard Medical School Haselkorn, University of Chicago Dr Lionel Jaffe, Marine Biological Laboratory Dr Robert P Northeastern Dr J Futrelle, University Woodland Hastings, Harvard University Dr William R Jeffery, University of Maryland Dr L Raymond Hayes, Jr, Howard University Dr Diana E. J Jennings, Marine Biological Dr. Howaida Gabr, Suez Canal University Dr Diane E Heck, Rutgers University Laboratory Dr David C Rockefeller Dr Gadsby, The University Jonathan Joseph Henry, University of Illinois Dr Daniel Johnston, Baylor College of Medicine Dr Harold Gainer, National Institutes of Health Dr Peter K Hepler, University of Massachusetts Dr Teresa L Z Jones, National Institutes Dr Robert M Galatzer-Levy, Chicago, IL Dr Walter R Herndon, University of Tennessee of Health Dr G Institution Joseph Gall, Carnegie Prof Avram Hershko, Technion-lsrael Institute of Dr Robert K Josephson, University of California Dr Michael A Gallo, UMDNJ-Robert Wood Technology, Israel Dr Leonard K Kaczmarek, Yale University School Johnson Medical School Dr Theodore T Herskovits, Fordham University of Medicine Dr Alan Monell Chemical H Gelperm, Dr Howard Hiatt, Bngham and Women's Dr Gabor Kaley, New York Medical College Senses Center Hospital Dr Jane C Kaltenbach, Mount Holyoke College

Dr James L III, Weill Medical Dr German, College Stephen M Highstem, Washington Dr Benjamin Kaminer, Boston University of Cornell University University School of Medicine Medical School Dr Martin Brandeis Gibbs, University Dr John G Hildebrand, University of Arizona Dr Edna S Kaneshiro, University of Cincinnati Dr Anne E Marine Giblin, Biological Laboratory Dr Richard W Hill, Michigan State University Dr Ehud Kaplan, Mount Sinai School of Dr A. Jane Gibson, Enta, NH Dr Robert B. Hill, University of Rhode Island Medicine Dr Prosser Gifford, Library of Congress Dr Susan D Hill, Michigan State University Dr Stephen J Karakashian, Milwaukie, OR Prof Giovanni Universita di Giudice, Dr Llewellya W Hillis, Marine Biological Dr Arthur Karlin, Columbia University Palermo, Italy Laboratory Dr Morns John Karnovsky, Harvard Medical Dr Antonio Giuditta, Universita di Napoli Dr Edward H Hinchcliffe, University of School

"Fedenco II," Italy Massachusetts Medical School Mr H Ernst Keller, Carl Zeiss, Inc. Dr Paul Glynn, Brunswick, ME Dr Michael Hmes, Yale University School Dr. Darcy B. Kelley, Columbia University Mr William T Chairman Golden, Emeritus, of Medicine Dr Robert E Kelly, Woods Hole, MA American Museum Dr Gregory J Hinkle, Millenium Dr Norman E Kemp, University of Michigan of Natural History Pharmaceuticals Mr John P Kendall, Faneuil Hall Associates Dr. Robert D Northwestern Goldman, University Dr Gertrude W. Hinsch, University of Mr Louis M Kerr, Marine Biological Laboratory Medical School South Florida Dr Alexander Keynan, Israel Academy of Dr Paul K Goldsmith, National Institutes Dr Jan Hinsch, Leica, Inc Sciences/Humanities, Israel of Health Dr John E Hobbie, Marine Biological Dr Shahid M M Khan, SUNY Upstate Dr H Timothy Goldsmith, Yale University Laboratory Medical University Dr Moise H Goldstein, Jr, The Johns Hopkins Dr Alan J Hodge, San Diego, CA Dr Kamran Khodakhah, Albert Einstein College University (deceased 2002) of Medicine Dr Robert Michael Gould, NYS Institute of Dr Joseph F Hoffman, Yale University School Dr Daniel P Kiehart, Duke University Basic Research of Medicine Medical Center Mr Dick Doreen Grace, Grace Fund Dr George G Holz, IV, New York University Dr Irving M Klotz, Northwestern University Dr Werner M Graf, College of France, France Medical Center Mr Robert A Knudson, Marine Biological Dr Philip Grant, National Institutes of Health Dr Charles S Hopkinson, Jr, Marine Laboratory Dr Judith P Grassle, Rutgers University Biological Laboratory Dr Samuel S Koide, The Rockefeller University Dr Katherine G. Graubard, University of Dr James C Houk, Northwestern University Sir Hans Kornberg, Boston University Washington Medical School Dr Edward M Kosower, Tel-Aviv University, Israel Dr E. Peter Greenberg, University of Iowa Dr Ronald R Hoy, Cornell University Dr Stephen M Krane, Massachusetts Dr Michael J Greenberg, University of Florida Dr Alice S Huang, California Institute of General Hospital Dr. Mary J Greer, New York, NY Technology Dr Robert Krauss, Denton, MD R Dr Donald Griffin, Harvard University Dr Linda A Hufnagel-Zackroff, University of Dr Edward A Kravitz, Harvard Medical School Dr Albert York Grossman, New University Rhode Island Dr William B Knstan, Jr., University of California, Medical Center Dr William D Hummon, Ohio University San Diego Prof Lawrence Grossman, The Johns Dr Susie H Humphreys, Food and Drug Dr Andrew M Kropmski, Queen's University, Hopkins University Administration Canada Dr. Yosef Gruenbaum, The Hebrew University Dr. Tom Humphreys, University of Hawaii Dr Damien P Kuffler, Institute of Neurobiology of Jerusalem Dr Tim Hunt, ICRF Clare Hall Labs, England Dr. William J Kuhns, The Hospital for Sick Dr John A Gruner, Cephalon, Inc Children, Canada R90

Dartmouth Dr Ada L. Foundation for Blood Research Dr Joseph G. Kunkel, University of Massachusetts Dr Frances V McCann Murray, Olins, Dr Alan M, Kuzinan, Marine Biological Laboratory Medical School Dr Donald E. Olins, Foundation for Blood Research Ms. Jane A McLaughlin, Marine Biological Dr James L Oschman, Dover, NH Dr Aimlee D laderman. Vale University Laboratory

' F of Texas Dr, Robert E Rensselaer Dr Laurie J. Landeau, Li ,tov. '!, c Dr Robert McMahon, University Palazzo, Polytechnic Island Institute Dr Dennis M D La-"-' -y Hospital Dr. Thomas Meedel, Rhode College of Cleveland Prof Ian A Meinertzhagen, Dalhousie Dr John D Palmer, University of Massachusetts Institutes of Health Canada Dr. Harish C National Institutes of Health Dr. Story C La", is, National University, Pant, Dr David L,v >.vnr, University of Miami Dr Dennis E Meiss, Immunodiagnostic Dr George D Pappas, University of Illinois Dr. George M. Langford, Dartmouth College Laboratories Dr Arthur B Pardee, Dana-Farber Cancer Institute Dr Rosevelt L of Dr Jeffrey Laskin, University of Medicine and Dr Jerry M Melillo, Marine Biological Laboratory Pardy, University Nebraska Dentistry of New Jersey Dr DeForest Mellon, Jr, University of Virginia Dr James L Parmentier, International Health Dr, Nechama Lasser-Ross, New York Mr. Richard P Mellon, Laughlmtown, PA Organization Medical College Dr Michael E Mendelsohn, New England Dr Thoru Pederson, University of Massachusetts Dr Leonard Laster, University of Massachusetts Medical Center Medical Center Medical School Dr Allen F Mensmger, University of Minnesota Dr Courtland D Perkins, Alexandria, VA Dr Alan Laties, Scheie Eye Institute Dr Melanie Pratt Mernman, Touchstone Dr Philip Person, Flushing, NY Dr Hans Laufer, University of Connecticut Consulting Dr Bruce J Peterson, Marine Biological Laboratory Dr Paul B Lazarow, Mount Sinai - School Dr Matthew Meselson, Harvard University Dr Ronald Pethig, University College of North of Medicine Dr Ricardo Miledi, University of California, Irvine Wales, UK Mr Maurice Lazarus, Federated Department Dr Roger D Milkman, University of Iowa Dr Ronald J Pfohl, Miami University Stores Dr Andrew L Miller, Hong Kong University Dr Sidney K Pierce, Jr, University of South Florida Dr Edward R Leadbetter, University of of Science and Technology Dr David E Pleasure, Children's Hospital Connecticut Mr Thomas J. Miller, Concord, MA Dr Jeanne S. Poindexter, Barnard College Dr Joshua Lederberg, The Rockefeller University Dr Gradimir Misevic, University Hospital Dr Harvey B Pollard, U S U H S Dr John J Lee, City College of CUNY of Basel, Switzerland Dr Thomas D Pollard, Yale University Mr Donald B Lehy, North Falmouth, MA Dr Ralph Mitchell, Harvard University Dr Beverly H Porter, Columbia, MD Dr. Stephen B Leighton, Beecher Instruments Dr Timothy Mitchison, Harvard University Dr Mary E Porter, University of Minnesota Dr Aaron B. Lerner, Yale University School Medical School Dr. David D. Potter, Harvard Medical School of Medicine Dr Hiroyoshi Miyakawa, Tokyo College of Dr Maureen K Powers, San Pablo, CA Dr Jack Levin, University of California School Pharmacy, Japan Dr Robert A Prendergast, Johns Hopkins University of Medicine Dr David M Miyamoto, Drew University Dr David J. Prior, Northern Arizona University Dr Michael S Levine, University of California Dr. Merle Mizell, Tulane University Dr Robert D. Prusch, Gonzaga University Dr Richard B. Levine, University of Arizona Dr Jorge E Moreira, National Institutes of Health Dr Dale Purves, Duke University Medical Center Dr Francoise Levmthal, Columbia University Dr. James G Morin, Cornell University Prof Irwin B. Levitan, University of Pennsylvania Dr. Leyla de Toledo Worrell, Rush-Presbyterian- Dr. James P Quigley, The Scripps Research Institute School of Medicine St Lukes

Dr Richard W Linck, University of Minnesota Dr Stephen S Morse, Columbia University Mr Irving W Rabb, Cambridge, MA School of Medicine Dr Andrew W Murray, Harvard University Dr. Harvey Rabin, Rockville, MD B Dr Raymond J Lipicky, Food and Drug Dr. Michael Rabinowitz, Boston, MA Administration Dr Samuel M Nabrit, Atlanta, GA Dr Nancy S Rafferty, Marine Biological Laboratory Dr. John E Lisman, Brandeis University Dr Knute J Nadelhoffer, National Science Dr Robert F Rakowski, Ohio University Dr. Anthony Liuzzi, Boston, MA Foundation Dr Fidel Ramon, Universidad Nacional Autonoma Dr Rodolfo R Llinas, New York Unversity Dr. Ronald L Nagel, Albert Einstein College de Mexico, Mexico Medical Center of Medicine Dr Edward B Rastetter, Marine Biological of Dr Phillip S Lobel, Boston University Marine Dr Yasuko Nakajima, University Illinois, Laboratory

Program, Marine Biological Laboratory College of Medicine Dr Lionel I Rebhun, University of Virginia Dr Werner R Loewenstein, Falmouth, MA Prof Toshio Narahashi, Northwestern University (deceased 2002} R Dr Irving M London, Harvard-MIT Medical School Dr John Reddan, Oakland University of Health Dr Frank J. Longo, University of Iowa Dr Enrico Nasi, Boston University School Dr. Thomas S Reese, National Institutes Dr Louise M Luckenbill, Falmouth, MA of Medicine Dr Carol L Reinisch, Marine Biological Laboratory Dr. Christopher Neill, Marine Biological Dr Edward F MacNichol, Jr, Boston University Laboratory Dr Frederick R Rickles, George Washington School of Medicine Margaret C Nelson, Ph.D., Cornell University University Dr Jane Ann Maienschein, Arizona State Dr. Peter A. Nickerson, SUNY, Buffalo Dr Conly L Rieder, Wadsworth Center University Dr Santo V Nicosia, University of South Florida Dr. Monica Riley, Marine Biological Laboratory Dr Craig C Malbon, State University of New York Ms Catherine N Norton, Marine Biological Dr Harris Ripps, University of Ilinois at Chicago Dr Robert P Malchow, University of Illinois, Laboratory Dr J Murdoch Ritchie, Yale University School Chicago Dr Michael P Nusbaurn, University of of Medicine Dr. Richard S Manalis, Indiana-Purdue University Pennsylvania School of Medicine Dr Lawrence C Rome, University of Dr Lynn Margulis, University of Massachusetts Pennsylvania Dr Andrew C Marmucci, Mercerville, NJ Mr Jonathan O'Herron, Lazard Freres & Company Dr Jack Rosenbluth, New York University Dr L Jr of Dr Ana Lia of School of Medicine Joe Martinez, , University Texas Obaid, University Pennsylvania Fraser Dr Luigi Mastroianni, Jr, Hospital of University School of Medicine Dr Raja Rosenbluth, Simon University of Pennsylvania Dr Shinpei Ohki, SUNY at Buffalo Dr Allan Rosenfield, Columbia University School Dr David Mauzerail, Rockefeller University Dr Rudolf Oldenbourg, Marine Biological of Public Health Dr M Lynne McAnelly, University of Texas Laboratory Dr Herbert S Rosenkranz, Florida Atlantic Dr Andrew G McArthur, Marine Biological Dr James L Olds, George Mason University University Laboratory R9I

Dr William N Ross, New York Medical College Dr Abraham Spector, Columbia University Dr Patricia Wadsworth, University of Mr Rudi Rottenfusser, Carl Zeiss Inc Dr Johanna E Speksnijder, Odikj, The Massachusetts Dr Lewis P Institute Netherlands Rowland, Neurological Dr Norman R Wamwnght, Marine Biological Dr Joan V Ruderman, Harvard Medical School Dr David C Spray, Albert Einstein College Laboratory Dr Medicine John D Rummel, NASA Headquarters of Dr Byron H Waksman, New York University Dr Norman B. Rushforth, Case Western Dr Kenneth R Spring, National Institutes Medical Center Reserve University of Health Dr Betty Wall, Woods Hole, MA Dr William Devine Dr Russell-Hunter, Easton, MD John H Steele, Woods Hole Oceanographic Dr Lawrence J Wangh, Brandeis University Institution Dr Robert C Warner, Laguna Beach, CA Dr Mary Beth Saffo, Harvard University Dr Antoinette Stemacker, University of Dr Leonard Warren, Wistar Institute Dr Guy Salama, University of Pittsburgh Puerto Rico Dr. John B Waterbury, Woods Hole Dr Edward D Salmon, University of Dr Malcolm S Steinberg, Princeton University Oceanographic Institution North Carolina Dr Andreas C Stemmer, Institut fuer Robotik, Dr Stephen G Waxman, Yale Medical School Dr Abigail Salyers, University of Illinois Switzerland Dr Annemane Weber, University of Pennsylvania Prof Brian M of Prof Ph Salzberg, University Johan Stenflo, M D , D , University of School of Medicine Pennsylvania School of Medicine Lund, Sweden Dr Janis C Weeks, University of Oregon Dr Jean M Sanger, University of Pennsylvania Mr Paul A Steudler, Marine Biological Laboratory Dr. Earl Weidner, Louisiana State University School of Dr Darrell R. Medicine Stokes, Emory University Dr Alice Sara Weiss, Silver Spring, MD Dr W. Joseph Sanger, University of Pennsylvania Dr Elijah W Stommel, Dartmouth Hitchcock Dr. Dieter G Weiss, University of Rostock, Medical Center Medical Center Germany Dr. John Dr. W Saunders, Jr. Waquoit, MA Alfred Stracher, SUNY Health Science Center Dr Leon P Weiss, University of Pennsylvania K Prof- Howard Schachman, University of at Brooklyn School of Veterinary Medicine California Dr Felix Strumwasser, East Falmouth, MA Dr Mansa C Weiss, Paoli Memorial Hospital Dr. Gerald P of Dr E Schatten, University Pittsburgh Ann Stuart, University of North Carolina at Dr Gerald Weissmann, New York University Dr Arlene C Schmeer, Mercenene Cancer Chapel Hill Medical Center Research Institute Dr Mutsuyuki Sugimon, New York University Dr Jennifer J Wernegreen, Marine Biological Dr. Herbert Schuel, SUNY at Buffalo Medical Center Laboratory Dr Lawrence of Dr Schwartz, University William C Summers, Western Washington Dr Monte Westerfield, University of Oregon Massachusetts University Dr J Richard Whittaker, University of New Dr A Nicola Schweitzer, Brooklme, MA Dr Kathy A Suprenant, University of Kansas Brunswick Dr Felix E Schweizer, University of California, Prof Mary Anne Sydlik, Hope College Dr Torsten N Wiesel, The Rockefeller University Los Angeles Dr Andrew G Szent-Gyorgyi, Brandeis University Dr Darcy B. Wilson, Torrey Pines Institute Dr Sheldon J Segal, The Population Council Dr T Hastings Wilson, Harvard Medical School Dr Stephen Lament Senft, Woods Hole, MA Dr Marvin L Tanzer, University of Connecticut, Dr Beatrice Wittenberg, Albert Einstein College Dr Douglas R Shanklin, University of Tennessee School of Dental Medicine of Medicine Dr Nadav The Institute Dr Shashar, Interuniversity Ichiji Tasaki, National Institutes of Health Dr Jonathan B Wittenberg, Albert Einstein of Eilat, Israel Dr Edwin W Taylor, University of Chicago College of Medicine Dr Victor E. Harvard Shashoua, Medical School Dr William H Telfer, University of Pennsylvania Dr William F Wonderlin, West Virginia University Dr Gaius R Shaver, Marine Biological Dr Bruce Telzer, Pomona College Dr Mary Kate Worden, University of Virginia Laboratory Prof Mark Terasaki, University of Connecticut Dr Basil V Worgul, Columbia University Dr. John R. Shaver, Michigan State University Health Center Dr Chau Hsiung Wu, Northwestern University (deceased 2003) Dr James G Townsel, Meharry Medical College Medical School Dr Michael P Sheetz, Columbia University Dr David M Travis, Woods Hole, MA Dr Charles R Wyttenbach, University of Kansas Dr David Sheprow, Boston University Dr Steven N Treistman, University of Dr Irwin W Sherman, University of California Massachusetts Medical Center Dr. Harold H. Zakon, University of Texas Dr Osamu Shimomura, Falmouth, MA Dr Walter Troll, NYU Medical Center Dr Seymour Zigman, Falmouth, MA

Mr Alan M F. Shipley, Forestdale, MA Dr Robert Troxler, Boston University School Dr Michael J Zigmond, University of Pittsburgh Dr Robert B Silver, Wayne State University of Medicine Dr Joshua J. Zimmerberg, National Institutes Dr K Kathleen Siwicki, Swarthmore College Dr Kenyon S Tweedell, University of Notre Dame of Health Dr Dorothy M Skinner, Falmouth, MA Dr Mark L Tykocinski, Case Western Reserve Dr Steven J Zottoli, Williams College Dr Roger D Sloboda, Dartmouth College University Dr Greenfield Sluder, University of Prof Michael Tytell, Wake Forest University Massachusetts Medical Center School of Medicine

Dr Peter J S Smith, Marine Biological Laboratory Dr. Hiroshi Ueno, Kyoto University, Japan Dr Stephen J Smith, Stanford University School of Medicine Dr Ivan Valiela, Boston University Marine Program Dr Roxanna S Smolowitz, Marine Biological Dr Richard Vallee, University College of Laboratory Physicians & Surgeons Dr Mitchell L Sogm, Marine Biological Mr. John J Valois, Woods Hole, MA Laboratory Dr Cindy Lee Van Dover, The College of William Dr Martha M Sorenson, Cidade Universitana- and Mary UFRJ, Brazil Dr Kensal E Van Holde, Oregon State University Dr William T Speck, Marine Biological Laboratory R92

ASSOCIATES

Dr and Mrs Richard Bennet I Patron Dr. and Mrs Frank M, Child Harvey Dr and Mrs Arnold M Clark Dr and Mrs J Woodland Hastings Dr R Mr and Mrs. MaicoIm Campbell Mr and Mrs James M. Clean/ Robert Haubnch The Honorable and Mrs. John S Langford Dr and Mrs Laurence P Cloud Mrs Elizabeth Heald Dr and Mrs Edward F MacNichol, Jr Drs Harry Conner and Carol Scott-Conner Mr and Mrs Edward S Heard H. Mrs William O. (Miles. II Mr and Mrs Donald B Cook Dr and Mrs Howard Hiatt Mr and Mrs Theron S Curtis, Jr Mr and Mrs David Hibbitt Dr Hillis Dr Associate Mr and Mrs Joel Davis Llewellya and Paul Colmvaux [Sustaining Mr and Mrs Joseph L Dixon Dr and Mrs John E Hobbie Mr and Mrs F, Gerald Dr Peter A Mr and Mrs. David Bakalar Douglass Hoenig Dr and Mrs John E. Mr and Mrs Gerald J Holtz Mr and Mrs Norman Bernstein Dowlmg Mr and Mrs W J Drs Francis C Hoskm and Elizabeth Farnhan Mr Bnan Bragmton-Smith Doyle Dr and Mrs Arthur Brooks DuBois Mrs Carmela J Huettner Inc. Bufftree Building Co , Mr and Mrs Robert Elias Ms Susan A Huettner Mrs Martha Saunders Ferguson Mr and Mrs Jerome Dr and Mrs Inoue Dr David Forkosh and Dr Linda Hirshman Fanger Shmya Dr and Mrs Michael J Fishbein Dr and Mrs Kurt J Isselbacher Dr and Mrs. Leonard Laster Mr and Mrs Freeman Mrs D Dr and Mrs John W Rowe Howard G Mary Janney Dr and Mrs Robert A Frosch Dr and Mrs James E. Johnson

Dr and Mrs John J. Funkhouser Mrs Sally S, Joslin Associate | Supporting Dr and Mrs Mordecai L Gabriel Dr and Mrs Benjamin Kammer Dr and Mrs David Garber Dr and Mrs Morns John Karnovsky Mrs Clowes Margaret Miss Eleanor Garfield Dr and Mrs George Katz Mrs Cross Sally Dr and Mrs James L German, HI Mr and Mrs Arthur King Ms Anne R DuBois Dr and Mrs Prosser Gifford Mr and Mrs Paul W Knaplund Mr Clifton H Eaton Dr and Mrs Murray Glusman Mr and Mrs. A. Sidney Knowles, Jr Dr and Mrs Harold S Ginsberg Dr. and Mrs Moise H Goldstein Mr and Mrs Walter E Knox Mrs Rebeckah DuBois Glazebrook Mrs Ann Goodman and Dr. Arthur Pardee Sir Hans and Lady Kornberg Drs Alfred and Joan Goldberg Dr. S. Mr and Mrs Charles Goodwin, III and Mrs Andrew Kulin Ms Hare Penelope Mr and Mrs Frederic Greenman Mr Ezra Laderman Mr and Mrs. Gary G Hayward Dr and Mrs Thomas C Gregg Dr and Mrs George M Langford Mr and Mrs William K Mackey, Esq Dr and Mrs Newton H Gresser Dr Hans Laufer Dr. and Mrs William M. McDermott Ms Kathryn Hackett Dr and Mrs John J Lee Mr and Mrs Robert Parkinson Mr Russ Dr and Mrs Harlyn O Halvorson Lemcke Mr. and Mrs. William J. Pechilis Mr and Mrs Benjamin Handelman Mr. and Mrs James E Lloyd Dr and Mrs Alan D Perlmutter Mr and Mrs Walter J Salmon Mrs Anne W Sawyer Dr John Tochko and Mrs. Christina Myles-Tochko THE 2001-2002 FALMOUTH FORUM SERIES sponsored by the MBi Associates [Family Membership

Dr and Mrs David E Adelberg October 5, 2001 Dr and Mrs Dean C Allard, Jr "Why I Sing in the Shower" Dr Peggy Alsup Keith Lockhart, Conductor, The Boston Pops Orchestra Mr and Mrs Douglas Amon Drs James and Helene Anderson October 19, 2001 Dr and Mrs Samuel C Armstrong "Memoirs of a Geisha: The Making of a Novel" Mr and Mrs Duncan P. Aspinwall Arthur Golden, Author, Memoirs of a Geisha Mr and Mrs Donald R, Aukamp Mr and Mrs John M Baitsell December 7, 2001 Dr and Mrs Robert B Barlow, Jr "An Evening with Norm Abram" Mr and Mrs John Barnes Norm Abram, Master Carpenter and host of The New Yankee Workshop Dr and Mrs Harriet P Bemheimer Mr and Mrs Robert O Bigelow January 18, 2002 Dr and Mrs Edward G Boettiger "The Great Powers and the East Mediterranean World" Mr and Mrs Kendall 8 Bohr Erik Goldstein, Chairman, Department of International Relations; Dr and Mrs Thomas A Borgese Professor of International Relations, Boston University Dr and Mrs Francis P Bowles Mr and Mrs Peter Boyer 1 2002 February , Mr and Mrs Thomas A. Brown "Around the Other Round Stone Barn: The Restoration, Dr and Mrs John B Buck History, and Relevance of the Hancock Shaker Community" Mr and Mrs William O Burwell Mary Rentz, Past-President, Board of Trustees, Hancock Shaker Village Mr and M's Bruce E. Buxton Dr and Mr, Richard L Chappell Friday, March 1, 2002 "Osteoporosis: The Research Frontier - Hopes for a Cure" Bjorn R. Olsen, Hersey Professor of Cell Biology; Harvard-Forsyth Professor of Oral Biology; Chairman, Harvard-Forsyth Department of Oral Biology, Harvard Medical School R93

ASSOCIATES EXECUTIVE BOARD

Ruth Ann taster, President Sallle Giffen, Vice-President

Kitty Brown, Treasurer Mr. and Mrs Richard M Paulson, Jr Ruth Shephard. Secretary I Individual Membership Dr. and Mrs John B Pearce Mrs Pendleton Tammy Amon Nancy Mr Richard A Ahern Barnes Mr and Mrs John 8 Pen Helen Dr Nina Stromgren Allen Peter Dr and Mrs Courtland D. Perkins Boyer Mrs Fredenca Z Alpert Dr and Mrs Person Bruce Button Philip Mr Dean N Arden Julie Child Mr Frederick S Peters Mrs. Ellen Prosser Armstrong Mrs. Grace M Peters Martha Ferguson Mr Garfield M Arthur Mr and Mrs E Joel Peterson Thomas Gregg Mrs Barbara Atwood Mr. and Mrs Harold Pilskaln James Johnson Mrs June Atwood Alice Knowles Mr and Mrs Andrew H Plevin Mr. Everett E Bagley Mr. and Mrs George H Hans Kornberg Plough Ms. Megan E Barrasso Rebecca Lash Dr and Mrs Aubrey Pothier, Jr. Ms Patricia M. Barry Susan Loucks Mr and Mrs Allan Ray Putnam Mr Mike Barry Mrs Lionel I Rebhun Jack Pearce Dr Millicent Bell Alan Perlmutter Dr and Mrs George T Reynolds Mr C John Berg Dr and Mrs Harns Ripps Virginia Reynolds Ms Olive C Beverly Salmon Ms Jean Roberts Marjorie Mr George Billings Rev Michael Robertson and Dr. Robertson Volker Ulbrich Emmy Mrs Ellen F Binda Drs. Priscilla and John Roslansky Ms. Avis Blomberg Ex-officio members Mr and Mrs John D Ross Dr. Robert H Broyles William T. Director & MBL Dr and Mrs John W Saunders, Jr Speck, CEO, Mr. Joseph W Burke Mr and Mrs Schuster John E. Dowling, President of the Savely Mrs Barbara Gates Burwell Mr and Mrs Harold H Sears Corporation, MBL J G. Butch Dr and Mrs Sheldon J Sheldon J. Segal, Chairman of the Board Segal Dr Graciela C Candelas Dr and Mrs Robert Seidler of Trustees, MBL Mr Frank C Carotenuto Mr and Mrs Daniel Shearer Dr Robert H Carner Dr and Mrs David Associates Administrator Sheprow Dr Chia-Yen Chen Dr. and Mrs Irwm Sherman Susan Joslin Dr Sallie Chisholm Mr and Mrs Bertram R Silver Ms Paula Ciara Mr and Mrs Jonathan O Simonds Mrs Octavia C Clement Mr and Mrs John A Simounan Dr Jewel Plummer Cobb Drs Frederick and Marguerite Smith Mrs Margaret H Coburn Drs William Speck and Evelyn Lipper Dr Seymour S Cohen Dr and Mrs L. Sr Guy Steele, Ms Genevieve Coleman Dr and Mrs Alan B Steinbach Associates, continued Ms Anne S Concannon Dr and Mrs William K Stephenson Ms Margaret S Cooper Dr and Mrs Thomas R Stetson Dr and Mrs Laszlo Lorand Dr D Eugene Copeland Mr and Mrs E Kent Swift, Jr Mr Richard C Levering Mrs. Molly N. Cornell Mr and Mrs Gerard L Swope Mr and Mrs Francis C Lowell, Jr. Dr Vincent Cowling Mr and Mrs Emil D Tietje, Jr Mrs Phyllis M MacNeil Mrs Marilyn E Crandall Mr D. Thomas Mr and Mrs Joseph Martyna Trigg Ms Cathleen Creedon Dr. and Mrs Walter Troll Drs Luigi and Elaine Mastroiann: Ms Helen M. Crossley Prof and Mrs Michael Tytell Dr and Mrs Robert T McCluskey Ms Dorothy Crossley Mr. and Mrs Volker Ulbrich Mr and Mrs Derek J McDonald Mrs Villa B Crowell Mr and Mrs. John J Valois Mr and Mrs James McSherry Mrs Dons M Curran Drs. Claude and Dorothy Villee Mrs Nawrie Meigs-Brown Mrs Elizabeth M Davis Dr John Waterbury and Ms Vicky Cullen Dr. and Mrs Jerry M Melillo Ms Maureen Davis Mr and Mrs John T. Weeks Dr Martin Mendelson Ms Carol Reimann DeYoung Dr and Mrs Gerald Weissmann Mr and Mrs Richard Meyers Mrs Virginia A Dierker Dr. and Mrs. Paul S Wheeler Mr. and Mrs Charles A Mitchell Mr David L Donovan Ms Mabel and Mr Rollins Dr and Mrs Merle Mizell Whelpley George Ms Suzanne Droban Mrs. Geoffrey Whitney Dr. and Mrs Charles H Montgomery Ms Maureen J. Ougan Mr. and Mrs. H Wilke Mr and Mrs Stephen A Moore Lynn Ms. Deborah Dunn Mr and Mrs. Leslie J Wilson Mr James V Moynihan Mrs Frances E Eastman Dr and Mrs T Hastings Wilson Mr. and Mrs. Lewis Nassikas Dr Frank Egloff Mr and Mrs. Leonard M. Wilson Dr. and Mrs John E Naugle Ms. Elizabeth Egloff Mr and Mrs Richard Yoder Dr. Pamela Nelson and Mr Christopher Olmsted Mrs Eleanor B Faithorn Mrs Manlyn G Zacks Mr. and Mrs Frank L Nickerson Ms Helen C Farnngton Mr and Mrs Bruce Zimmerli Dr. and Mrs Clifford T O'Connell Mrs Ruth Alice Fitz

Mr and Mrs. James J O'Connor Ms Sylvia M Flanagan Mr and Mrs Daniel O'Grady Mr John W Folmo, Jr Mr and Ms David R Palmer Dr and Mrs Clement E Papazian R94

GIFT SHOP VOLUNTEERS

Marion Adeiburg Beth Berne Avis Blomberg Gloria Borgese Julie Child Janet Daniels Carol De Young Frances Eastman Pat Ferguson Barbara Grossman Jean Halvorson Associates, continued Hanna Hastings Ms Mary W McKoan Mrs Ruth Shephard Marcella Katz Ms Jane A McLaughlm Mr Frank Shephard Donna Ms Louise McManus Ms Shiebler Kornberg Mr Paul J. Freyheit Dorothy Barbara Little Ms Cornelia Hanna McMurtne Ms Enid K Sichel Mrs Ruth E Fye Florence Mixer Ms Paula A Dr D Silberman Mr Joseph C Gallagher Mealy Jeffrey Bertha Person Mrs Lois E Galvin Dr Carmen Merryman Mrs Phyllis J Silver Julie Ranlcin Miss Lan Ge Ms Vivagean V. Merz Mrs. Cynthia C Smith Arlene Marianne F Milkman Rogers Mrs Matilda L Gellis Mrs Mrs Louise M Specht Atholie Rosen Mrs Dons D Gerace Mrs Florence E Mixer Dr Evelyn Spiegel Mr Cynthia Smith Ms Sallie Giffen Ken Moffitt Mrs Helene E Spurrier Alice Todd Mrs. Janet F Gillette Mr Lawrence A Monte Dr Robert E Steele Natalie Trousof Ms Moor Mrs Eleanor Stembach Mr Michael P Goldring Cynthia Clare Wilber Ms Muriel Gould RADM Paul J Mulloy USN (Ret) Dr Malcolm S Steinberg Betty Wilson Mrs Winifred M Green Mrs Carol Murray Ms Eleanor Sterling Grace Witzell Mrs Eleanor M Nace Mrs. Jane Lazarow Stetten Ms Janet M Gregg Mr III Bunnie Zigman Mrs Jeanne B Griffith Mrs Anne Nelson Edward Stimpson, Mrs Barbara Grossman Dr Eliot H Nierman Mrs Elizabeth Stommel F Mrs Valerie A Hall Mr Edmund Nolan Ms Maren Studlien Ms Schiffer Noland Mr Albert H Swam Ms Mary Elizabeth Hamstrom Peggy Mrs Jane M Heald Ms Catherine N Norton Mr Dorman J Swartz Mr Mark Hollander Dr Renee Bennett O'Sullivan Mr James K Taylor Dr Jack S Parker Mrs Alice Todd Mrs Betsy Honey Mr David Jr Mr Arthur D Traub TOUR GUIDES Mr Roger W Hubbell Parker. Ms Alexandra Izzo Ms Carolyn L Parmenter Ms Natalie Trousof Ms Joan Pearlman Mr Louis C Turner Dr Diana E Jennings Dr Daniel A Pollen Eleanor Mrs Megan H. Jones Ms S Uhlmger Gloria Borgese Ms Barbara W Jones Mr Barry Pratt Ms Ciona Ulbrich Frank Child Mrs Joan T Kanwisher Ms Elizabeth T Price Ms Sylvia Vatuk Nancy Fraser Ms Dianne Purves Ms Dawn Mrs Sally Karush Vaughn Sallie Giffen Mrs Julia S Rankin Ms Susan Veeder Ms Patricia E Keoughan Ronald Glantz Dr M Mr Lee D Vincent Dr Peter N Kivy Magaret Rappaport Charles Mahoney Mrs Carol V Rasic Mr Arthur D Voorhis Ms Kathryn M Kleekamp Haskell Maude Mr Fred J Jr Mrs Ann Wadsworth Ms Margaret D Lakis Ravens, Andrew McArthur Ms W Rianhard Mrs Eve Warren Ms Meryl Langbort Mary Merz Vivagean Ms Rebecca Lash Ms Andrea Ricca Mr. Michael S Wemstein Carl Ollmer Mr William Lawrence Dr Mary Elizabeth Rice Ms Lillian Wendonf William Philips Dr Marian E LeFevre Ms Sandy L Richardson Dr Gary Wessel Julie Rankin Mr Edwin M Libbin Dr Monica Riley Mr George R Wezntak Howard Redpath Mrs- Lola E Robertson Mr White Mr Lennart Lindberg Gerry Sheila Silverberg Dr Steven R Mrs. Barbara C Little Rodermel Mrs Barbara Whitehead Mary Ulbrich Mrs. Sarah J Loessel Mrs Arlene Rogers Mrs Clare M Wilber John Valois Ms Susan Loucks Mrs Wendy E Rose Mrs Helen Wilson Mrs Atholie K Rosett Mrs Grace Witzell Mr Jeremy Loyd F Dr Zella Luria Dr Virginia Ross Ms Nancy Woitkoski Dr John D Rummel Mr Dale Ms Sallie G Lyon Wolfgram Mrs Rosalind Russell Mrs M York Mrs Margaret M MacLeish Dorothy Mrs Annemarie E Mahler Dr Albert Samuel Dr Linda Amaral Zettler Mr A Sanborn Mrs Bunnie Rose Mrs. Nancy R Malkiel Raymond Zigman Mr Brett Mandel and Dr Thomas Sbarra Mrs Margery P Zinn Ms Laura Wembaum Ms Mary M Scanlan Mrs Diane B Maranchie Mr Claude Schoepf Mr Samuel C Schon Mrs Marjorie Marshall Mrs Elsie M Scott Mrs Mary Hartwell Mavor Dr Cannan Mr Bill McGoey Cecily Selby Mrs Deborah G Senft Mr Pauf McGonigle Ms Neuron. Peter Koulen Dr Susan G Mcllwain Dorothy Sgarzi Mrs Charlotte Shemin R95

COUNCIL OF VISITORS

The purpose of the Council of Visitors is to increase awareness of the Marine Biological Laboratory and to inform members about the broad range of activities in research and educational programs. COV members serve as

ambassadores of the Laboratory, and thus raise visibility of fhe MBL.

Mr Robert W Ashton Dr Goodwin M Breinin Dr Sylvia A Earle Foundation New York Medical Center Bay University Deep Ocean Engineering New York. New York New York, New Yorlt Oakland. California

Mr Donald J Bainton Mr H Murray Bring Mr & Mrs Hoyt Ecker Continental Can Co New York, New York Vero Beach, Florida Boca Raton, Florida Mr John Callahan Mr Anthony B Evnin Mr David Bakalar Carpenter, Sheperd & Warden Venrock Associates

Chestnut Hi/I, Massachusetts New Lone/on, New Hampshire New York, New York

Dr George P Baker Mrs. Elizabeth Campanella Mr Michael Fenlon Massachusetts General West Fafmouth, Massachusetts Hospital Nathan Sallop Insurance Agency. Inc Boston, Massachusetts Boston, Massachusetts Dr R John Collier Dr Sumner A Barenberg Harvard Medical School Judah Folkman, M D Bernard Boston, Massachusetts Technologies Children's Hospital Chicago, Illinois Boston, Massachusetts Dr Stephen D Crocker Mr. Mel Barkan Bethesda, Mary/and Mrs Hadley Mack French The Barkan Companies Edsel & Eleanor Ford House Massachusetts Mr Michael J Cronin Boston, Grosse Pomte Farms. Michigan Cognition Corporation Mr Frederick Massachusetts Bay Bedford, Mr and Mrs Huib Geerlings Josephine Say Paul & C Michael Paul Boston, Massachusetts Foundation, Inc Mrs. Lynn W Piasecki Cunningham New York, New York Film and Videomaker, Piasecki Productions Mr Maynard Goldman New York, New York Maynard Goldman & Associates Mr Robert P Beech Boston, Massachusetts Component Software International, Inc Dr Anthony J Cutaia Mason, Ohio Inc Anheuser-Busch, Ms Charlotte I Hall St Missouri Louis, Edgartown, Massachusetts Mr George Berkowitz Sea Foods Dr, Lorenzo DiCarlo Legal Ms Penelope S Hare Al/ston. Massachusetts Mrs. Sally Stegeman DiCarlo West Falmouth, Massachusetts Ann Arbor. Michigan Jewelle and Nathaniel Bickford Mrs Elizabeth Heald New York, New York Dr Charles Di Cecca West Falmouth, Massachusetts Medford, Massachusetts Dr Elkan R Blout Dr Thomas R Hedges, Jr Harvard Medical School Mr Diarmaid H Douglas-Hamilton Neurological Institute, Pennsylvania Hospital Boston. Massachusetts Hamilton Thorne Research Philadelphia. Pennsylvania Beverly, Massachusetts Mr Malcolm K Brachman Drs Linda Hirshman and David Forkosh Northwest Oil Mr F du Pont Company Benjamin Brandeis University & FMH Foundation Dallas. Texas Du Pont Company Waltham, Massachusetts Deepwater, New Jersey

Continued Mitch Sogm, Elizabeth Armstrong Nosema locustae spores, Linda Amaral Zertler R96

COUNCILOR VISITORS MEETING JUNE 27, 28, 2002 Mr Robert S Shifman St Simon's Island, Georgia

Mr Modern Molecular Approaches to Global Infectious Diseases and Mrs Gregory Skau John R. David, M-D., Moderator Grosse Pomte Farms, Michigan Harvard School of Public Health Mr John C Stegeman A 21st Century Challenge: Using Genomics, Proteomics, and Molecular Campus Rentals Ann Immunology to Develop Vaccines for Malaria and Lung Cancer Arbor, Michigan Stephen L. Hoffman, M.D. Mr T Senior Vice President, Biologies Joseph Stewart, Jr Celera Genomics Skillman, New Jersey

Mr Richard H AIDS in Africa: New Epidemics, New Viruses Stowe Max Essex, D.V.M., Ph.D. Capital Counsel LLC Chairman, Department of Immunology and Infectious Diseases New York, New York Harvard School of Public Health Mr Gerard L Swope The Conundrum of Tuberculosis and HIV/AIDS Washington, DC

Jerrold J. Eilner, M.D. Mr John F Director, Center for Emerging and Re-Emerging Pathogens Swope New Jersey School of Medicine Concord, New Hampshire

Mr and Mrs Stephen E Taylor Mi/ton Massachusetts

Mr Samuel Thome Mrs Barbara W Hostetter Mr Michael T Martin Thorne Trading Campany, LLC Barr Foundation Manchester, Massachusetts SportsMark, Inc Boston, Massachusetts New York, New York Mrs Karen Tierney Mr Charles Hunter Massachusetts Mrs Christy Swift Maxwell Wellesley, Hunter Kessinger & Co Grosse Pomte Farms, Michigan Kansas City, Missouri Mrs Donna Vanden Bosch-Flynn Mr Ambrose Monell Spring Lake, New Jersey Mr Thomas J, Jr Hynes, G Linger Vetlesen Foundation Meredith & Grew, Inc Palm Beach, Florida Mr Benjamin S Warren III Boston, Massachusetts Grosse Pomte Farms, Michigan Dr Mark Novitch Mrs B R.N Mary D Janney Washington, DC Nancy Wemstein. Washington, D.C. The Hospice, Inc Mr David R Palmer Glen Ridge, New Jersey Dr Morris J Karnovsky David Ross Palmer & Associates Harvard Medical School S Wemstein, Waquoit, Massachusetts Stephen Esq Boston, Massachusetts Mornstown, New Jersey

Mr and Mrs Joseph P. Pellegnno Ms Ellyn V Korzun Boston, Massachusetts John C West. M D Goldman, Sachs & Co Danville, Pennsylvania

New York, New York Mr Robert Pierce, Jr Pierce Aluminum Co Mr Frederick J Weyerhaeuser Massachusetts Mr and Mrs Robert Lambrecht Franklin, Massachusetts Beverly, Boca Grande, Florida Mr Manus A Robinson Mrs Robin Wheeler Mr Rudy Landry Fundamental Investors Ltd West Falmouth, Massachusetts Massachusetts Pocasset. Key Biscayne, Florida Ms Rosalind C Whitehead Catherine C Lastavica, M D Mr Edward Rowland New York. New York Tufts University School of Medicine Tucker Anthony. Inc. Boston, Massachusetts Boston, Massachusetts Mrs Annette Williamson Forth Worth. Texas Dr Anna Logan Lawson Mr Andrew E Sabin Daleville, Virginia Sabin Metal Corporation East Hampton, New York Mr Joel A. Leavitt Massachusetts Boston, Ms Linda Sallop Nathan Sallop Insurance Agency, Inc. Mrs. Margaret Lilly Boston, Massachusetts West Falmouth, Massachusetts Mr Gregory A Sandomirsky Mr. Richard Lipkin Mintz Levin Cohen Ferns Glovsky & Popeo, PC Shipan Capital Boston, Massachusetts New York. New York

Dr Cecily C Selby New York. New York R97

ADMINISTRATIVE SUPPORT STAFF 1

Bulletin Services Office [Biological [Financial J Homer Chief Greenberg, Michael , Lane. Jr. W. Editor-in -Chief Financial Officer Hinkle. Pamela Clapp, McLean, David. Controller Richard J Managing Editor Mullen, , Manager, Child. Wendy Research Administration Gibson, Victoria R Adams, Taryn Schachmger, Carol H Aguiar, Deborah Bliss, Casey M Brady, Caroline Kenneth I Director's Office Crosby, Bonnie Jean Speck. William T.. Director Griffin, and Chief Executive Officer Lancaster, Cindy Donovan. Marcia H Newman, Melissa Nunes, Kenda Equal Employment Opportunity Solchenberger, Carolyn MacNeil. Jane L Stellrecht. Lynette

Veterinarian Services Stock Room

Smolowitz, Roxanna. Campus Schorer. Timothy M , Supervisor : Veterinarian Galatzer-Levy. David Allen, Taylor Olive, Jr, Charles W Photo Volker Bonacci, Lisa' by Steger Dalpe. Heather Purchasing Ehlen. Jill- Hall Jr, Lionel E., Supervisor Hancock, Amy Hunt, Lisa M Stukey. Jetley Widdiss, Brittany'

|Educational Programs [Housing and Conferences

M , Director Dawidowicz. Eliezar A , Director Beckwith, Mary Hamel, Carol C Fuglister. Charles K

Holzworth, Kelly Grasso, Deborah Knjger, Sally J Suzanne Central Microscopy Facility and Livingstone. General Use Rooms Oldham. Pamela Louis Diana Kerr, M . Supervisor Pento, Histen, Gavin 7 Stackhouse. Barbara Inzina, Jessica- Wagner, Carol Luther, Herbert Ogomo. Christopher On' Housekeeping : ; Parmenter, Marjone Bailey. Jeffrey Jr Photo by Elizabeth Armstrong Peterson, Martha B Barnes, Susan M Scanlon, John ? Barron, Laura : Bernos. Jessica Chen, Zhi Xm

(External Affairs Doherty. Bryant-' I Senior Staff David-" Carotenuto, Frank C . Director Johnston, Butcher, Valerie Hannigan, Catherine Mary Beckwith, Director of Housing and Conferences Faxon, Wendy P MacDonald. Cynthia C Frank Carotenuto, Director of External Affairs George, Mary McNamara, Noreen M Richard Cutler, Director of Facilities and Services Johnson, A Knstme Santiago. Crystal Lenny Dawidowicz, Director of Education Patch-Wing, Dolores Shum, Mei Wah Susan Goux, Director of Human Resources Quigley. Barbara A Waterbury. Matthew-" Roger Hanlon, Director of the Marine Resources Center Shaw, Kathleen L Pamela Clapp Hinkle. Director of Communications Homer Lane. Chief Financial Officer Associates Program |Human Resources Andrew Mattox, Environmental Health and Safety Manager Joslin, Susan Goux, Susan P, Director Richard Mullen. Manager of Research Administration Sgarzi. Dorothy J. Damery, Angela" Cathy Norton. Director of the MBL/WHOI Houser, Carmen Library William T Speck, Director and Chief Executive Officer Communications Office Snow, Linda Hinkle. Pamela Clapp Director Hemmerdinger, Catherine J. Erik Jonsson NAS Hartmann. Kelley' | Center, Hlista. Laurel' Carlisle, Ann-' Langill, Christine' Doherty. Joanne Liles, Beth R Ehchalt, Donald : Mansfield, Samantha Shurtleff, Joan Mock-Munoz De Luna, Dana- Including persons who joined or left the staff during 2001 Rullo. Gina Summer or temporary R98

Support staff, continued

Paul Cents for Information Division Josephine Bay Technology | Services, Projects and Facilities Mendoza, Duke Inzina, Barbara, Network Cutler, Richard D Comparative Molecular Manager , Director Mills, Stephen A Callahan, Michael- Biology and Evolution Enos, Joyce B Pratt, Barry 2 Alex 2 2 Lim, Pauline Cohen, Stackhouse, Aaron Rattacasa, Frank

Nih.ll, Tara Dematos, Christopher Settlemire, Donald Fournier, Pamela Apparatus Shepherd, Denise M Jones, Patricia L Atwood, Paul Sullivan, Brendon 2 Marine Resources Leary, Patrick Michael G Toner, Michael | Center Baptiste, Lowell, Hanlon, Roger T, Director Gregory Barnes, Franklin D Ware, Lynn M - Mountford, Rebecca J William Maddux, Betty L S Haskins, A David P, Santore, Gabnelle Remsen, Pratt, Barry Security and Projects Renna, Denis J Fleet, Barry M , Manager David B. Aquatic Resources Department Space, Transportation Services & Grounds Blunt, Hugh F 2 Wagner, Paul H., Fish Jr, David L Enos, Jr., Edward G , Hayes, Joseph Supervisor Superintendent Bailey, Jeffrey B Hathaway, Peter J. Dimond, James L 2 Boucher, Richard L. Kelley, Kevin Grossman, William M NASA Center for Advanced Brereton, Richard S 2 Lochhead, William M Studies in the Life Daniel John Klimm III, Henry W Space Clayton, Rozum, Sexton, Andrew W Sciences Collins, Paul J Scanlan, Melanie 2 2 Sterling, Andrew Blazis, Diana, Administrator Cutler, Matthew 2 2 Sterling, Christian Farrell, Heather Duane, James Sullivan, Daniel A. Illgen, Robert F The Center | Ecosystems 2 Tassman, Eugene Malchow, Robert Cave, Anthony, Center Research Clare 2 Whelan, Sean P (Safety Services McHugh, Administrator H Mendoza, 2 Center Mattox, Andrew , Environmental, Guy Nunez, Guillermo, William 2 MRC Life Support System Health, and Safety Manager Rogers, Research Administrator 2 William 2 Santoro, John Berthel, J. Mebane, N , Systems Elder, Kristopher Dorothy Operator Donovan, Suzanne J Carroll, James Research Space Administration Plant Operations and Maintenance Seifert, Mary Ann Hanley, Janice S Kaufmann, Sandra J Abbott, Thomas E., Supervisor Kuzirian, Alan Anderson, Lewis B Linnon, Beth Satellite/Periwinkle Children's Atwood, Paul R 2 Programs Auclair, Donald Robinson, Paulina H 2 Bailey, Jeffrey B 2 Barnes, John S IMBL/WHOI LIBRARY Butler, Meredith 2 Catherine N 2 Bryant, Horace Norton, , Director Camire, Aaron 2 W. Uhlmger, Eleanor, Assistant Guiffrida, Beth Cadose, James 2 Callahan, John J Director, MBL Library Halter, Sarah 2 2 Garrett Deveer, Joseph M Karalekas, Nina Cormier, 2 Elias, Michael Monahan, A Jean Langill, Susan 2 Ficher, Jason Nelson, Heidi Leveque, Rachel Person, Matthew Noonan, Brendan 2 Goehl, George 2 Walter Reuter, Laura Noonan, Patrick Gonsalves, Jr, W.

2 Jon R Riley, Jacqueline O'Connor, Caitlin Henderson, 2 House, James Stafford, Nancy Orfila, Cecelia 2 Robert Stout, Amy Plourde, Anna Howell, 2 Richard Walton, Jennifer Sturbaum, Sonja Langill, 2 Laurmo, Frank Swetish, Margaret 2 2 Mancevice, Connne Digital Processing Center Swiniarski, Kathryn Herbert Clark, Sarah Thamm, Jennifer McAdams III, M 2 Michael Hadway, Nancy Urciuoli, Karen McHugh, O 2 2 Mannix, Jessica Vachon, Julia 2 McQuillan, Jeffrey Reuter, Laura Westburg, Joanne