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STEROIDS ANTI SHOP INJECTABLE ORAL PCT HORMONES ESTROGENS ONLINE GENERIC BLOG Home / Oral Steroids Search products… Oral Steroids It’s no secret that the popularity of bodybuilding and weightlifting has led SEARCH to the rapid development of the pharmacological branch of medicine. Gone are the days when compulsory training was needed before taking sports equipment. Currently, any drugs intended for experienced and professional athletes have become available even to beginners. STEROIDS FOR SALE Testosterone Derivatives Most oral anabolic steroids are considered derivatives of testosterone. Through anabolic steroids, you can significantly increase endurance, strength indicators and effectively build muscle. Thanks to the male hormone, it is possible to achieve high results both during the training process, and at competitions at various levels. In addition, the high performance of a trained body allows you to recover quite quickly after maximum loads in physical and emotional terms and to safely begin further Alpha Pharma studies. Showing 1–12 of 32 Sort by popularity Dragon Pharma results Maxtreme Indian Brand BM Pharmaceuticals Healing Pharma Buy Andriol Buy Max-Drol Buy Oxa-Max Natco Pharma Testocaps Online Online Online $30.00 $89.00 $89.00 Sun Pharmaceuticals ADD TO ADD TO ADD TO CART CART CART FAQ Privacy Policy My Account Checkout Buy Magnum Buy Magnum Stanol Buy Magnum Cart Turnibol 10 Online 10 Online Oxymeth 50 Online Contact Us $44.00 $38.00 $64.00 Contact Us ADD TO ADD TO ADD TO CART CART CART PRODUCT TAGS Acyclovir (Zovirax) Amoxicillin Anastrozole Buy Magnum Buy Magnum D Bol Buy Modalert 200 Augmentin Oxandro 10 Online 10 Online Online $67.00 $39.00 $12.00 Azithromycin ADD TO ADD TO ADD TO CART CART CART Boldenone undecylenate (Equipose) Cabergoline (Cabaser) Clenbuterol hydrochloride (Clen) Clomiphene citrate (Clomid) Buy Modalert 100 Buy Superdrol 10 Buy Halotestin Drostanolone propionate Online Online Online (Masteron) $7.00 $58.00 $199.00 Dutasteride (Avodart) ADD TO ADD TO READ CART CART MORE Exemestane (Aromasin) Finasteride (Propecia) 1 2 3 → Fluoxymesterone (Halotestin) Furosemide (Lasix) HCG Human Growth Hormone (HGH) Isotretinoin (Accutane) Letrozole Liothyronine (T3) Mesterolone (Proviron) Methandienone oral (Dianabol) Methenolone acetate (Primobolan) Methenolone enanthate (Primobolan depot) Modafinil Nandrolone decanoate (Deca) Nandrolone phenylpropionate (NPP) Oxandrolone (Anavar) Oxymetholone (Anadrol) Premarin Sildenafil Citrate Stanozolol injection (Winstrol depot) Stanozolol oral (Winstrol) Sustanon 250 (Testosterone mix) Tadalafil Tamoxifen citrate (Nolvadex) Testosterone cypionate Testosterone enanthate Testosterone propionate Testosterone supplements Testosterone suspension Trenbolone acetate Trenbolone enanthate Trenbolone Hexa Trenbolone Hexa Turinabol (4- Chlorodehydromethyltestosterone) © Copyright 2019 - Fitness GYM WordPress Theme.

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MMC International BV
M.M.C. International Steroid Substances Steroid Test A Colour Steroid Test B Colour Steroid Test B Colour with UV Light Stanozolol/ Oxandrolone Test Clenbuterol/ Oxymetholone Test Ephedrine Test Alfadolone Orange Yellow Nil - - - Androsterone Orange Yellow White - - - Beclometasone Brown–yellow Orange Nil - - - Betamethasone Orange–brown Pink–Orange Nil - - - Boldenone Base (Equipoise, Ganabol) (pure powder) Warm red after 2 min. Dark Orange after 2 min. Bright Light Orange - - - Boldenone Undecanoate (oil) Dark brownish-red Dark Red Bright Light Orange - - - Boldenone Undecylenate (oil) Orange - Light Brown Dark Orange → Brown Bright Light Orange-Yellow - - - Carbenoxolone (CBX) Orange Yellow Yellow - - - Cholesterol Violet Orange White - - - Clenbuterol (Spiropent, Ventipulmin) - - - - Purple - Dark brown with yellow-green on the Dark brown with yellow-green on the Clomiphene (Androxal, Clomid, Omifin) Nil Dark brown to black No reaction Dark brown to black sides of the ampoule sides of the ampoule Cortisone Orange Yellow Green - - - Desoxycortone Blue–black Yellow Yellow - - - Dexamethasone Yellow Orange–pink Nil - - - Dienestrol Yellow Orange–red Nil - - - Diethylstilbestrol (DES) Orange (→yellow–green) Nil - - - Dimethisterone Brown–green Orange–red Yellow - - - Drostanolone Propionate (Masteron) (oil) Bright green Yellow-Orange Orange - - - Dydrogesterone (Duphaston) - Orange Green-Yellow - - - Enoxolone Orange Yellow Green-Yellow - - - Ephedrine (also for Pseudo- and Nor-Ephedrine) - - - - - Orange Estradiol (Oestradiol) Orange
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Toiminta Unita on Ulla La Mungukurti |
TOIMINTAUNITA USON 20180071390A1ULLA LA MUNGUKURTI | ( 19) United States (12 ) Patent Application Publication (10 ) Pub. No. : US 2018/ 0071390 A1 PATEL et al. (43 ) Pub . Date : Mar . 15 , 2018 ( 54 ) COMPOSITIONS OF PHARMACEUTICAL A61K 9 / 06 (2006 .01 ) ACTIVES CONTAINING DIETHYLENE A61K 9 /00 (2006 .01 ) GLYCOL MONOETHYL ETHER OR OTHER A61K 31 /573 ( 2006 .01 ) ALKYL DERIVATIVES A61K 31/ 565 ( 2006 .01 ) A61K 31/ 4439 ( 2006 . 01 ) ( 71 ) Applicant : THEMIS MEDICARE LIMITED , A61K 31 / 167 ( 2006 . 01 ) Mumbai (IN ) A61K 31 / 57 (2006 . 01) (52 ) U . S . CI. (72 ) Inventors : Dinesh Shantilal PATEL , Mumbai CPC .. .. .. A61K 47 / 10 ( 2013 . 01 ) ; A61K 9 /4858 ( IN ) ; Sachin Dinesh PATEL , Mumbai ( 2013 .01 ) ; A61K 9 /08 ( 2013 .01 ) ; A61K 9 / 06 ( IN ) ; Shashikant Prabhudas ( 2013 .01 ) ; A61K 9 / 0014 ( 2013 .01 ) ; A61K KURANI, Mumbai ( IN ) ; Madhavlal 31/ 573 ( 2013 .01 ) ; A61K 31 /57 ( 2013 .01 ) ; Govindlal PATEL , Mumbai ( IN ) A61K 31/ 565 ( 2013 .01 ) ; A61K 31 /4439 (73 ) Assignee : THEMIS MEDICARE LIMITED , ( 2013 .01 ) ; A61K 31/ 167 ( 2013 .01 ) ; A61K Mumbai (IN ) 9 /0048 ( 2013 .01 ) ; A61K 9 /0019 (2013 .01 ) ( 57 ) ABSTRACT (21 ) Appl. No .: 15 / 801, 390 The present invention relates to pharmaceutical composi tions of various pharmaceutical actives, especially lyophilic ( 22 ) Filed : Nov . 2 , 2017 and hydrophilic actives containing Diethylene glycol mono ethyl ether or other alkyl derivatives thereof as a primary Related U . S . Application Data vehicle and /or to pharmaceutical compositions utilizing (62 ) Division of application No. 14 /242 , 973 , filed on Apr. Diethylene glycol monoethyl ether or other alkyl derivatives 2 , 2014 , now Pat. No. 9 , 827 ,315 .
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(12) Patent Application Publication (10) Pub. No.: US 2014/0296.191 A1 PATEL Et Al
US 20140296.191A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0296.191 A1 PATEL et al. (43) Pub. Date: Oct. 2, 2014 (54) COMPOSITIONS OF PHARMACEUTICAL (52) U.S. Cl. ACTIVES CONTAINING DETHYLENE CPC ............... A61K 47/10 (2013.01); A61 K9/0019 GLYCOL MONOETHYLETHER OR OTHER (2013.01); A61 K9/0048 (2013.01); A61 K ALKYL DERVATIVES 45/06 (2013.01) USPC ........... 514/167: 514/177; 514/178: 514/450; (71) Applicant: THEMIS MEDICARE LIMITED, 514/334: 514/226.5: 514/449; 514/338; Mumbai (IN) 514/256; 514/570; 514/179; 514/174: 514/533; (72) Inventors: Dinesh Shantilal PATEL, Mumbai (IN); 514/629; 514/619 Sachin Dinesh PATEL, Mumbai (IN); Shashikant Prabhudas KURANI, Mumbai (IN); Madhavlal Govindlal (57) ABSTRACT PATEL, Mumbai (IN) (73) Assignee: THEMIS MEDICARE LIMITED, The present invention relates to pharmaceutical compositions Mumbai (IN) of various pharmaceutical actives, especially lyophilic and hydrophilic actives containing Diethylene glycol monoethyl (21) Appl. No.: 14/242,973 ether or other alkyl derivatives thereofas a primary vehicle and/or to pharmaceutical compositions utilizing Diethylene (22) Filed: Apr. 2, 2014 glycol monoethyl ether or other alkyl derivatives thereofas a primary vehicle or as a solvent system in preparation of Such (30) Foreign Application Priority Data pharmaceutical compositions. The pharmaceutical composi Apr. 2, 2013 (IN) ......................... 1287/MUMA2013 tions of the present invention are safe, non-toxic, exhibits enhanced physical stability compared to conventional formu Publication Classification lations containing such pharmaceutical actives and are Suit able for use as injectables for intravenous and intramuscular (51) Int. Cl. administration, as well as for use as a preformed solution/ A647/ (2006.01) liquid for filling in and preparation of capsules, tablets, nasal A6 IK 45/06 (2006.01) sprays, gargles, dermal applications, gels, topicals, liquid oral A6 IK9/00 (2006.01) dosage forms and other dosage forms.
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Chemical Muscle Enhancement (The BDR) by Author L
Chemical Muscle Enhancement (The BDR) By Author L. Rea TABLE OF CONTENTS 1. AAS INTRODUCTION ..PG’S 1-12 WARNING: READ FIRST OVER 20 YEARS AGO... WHY STEROIDS AND WHAT IS POSSIBLE? WHAT ARE STEROIDS? FEMALE HORMONE SYNTHESIS MALE HORMONE SYNTHESIS TESTOSTERONE... WHAT DOES IT DO? STEROIDS INCREASE PC SYNTHESIS STEROIDS EFFECT BLOOD VOLUME WHAT HAPPENS AFTER TESTOSTERONE MOLECULES LEAVE RECEPTORS? STEROIDS...GROWTH ON THE CELULAR LEVEL 2. DRUG REFERENCES AND DESCRIPTIONS..PG 12 ORAL ANABOLIC / ANDROGENIC STEROIDS..PG’S 13-30 INJECTABLE ANABOLIC / ANDROGENIC STEROIDS..PG’S 31-45 TESTOSTERONE AND ITS ESTERS..PG’S 45-61 NORTESTOSTERONE (NANDROLONE) AND ITS ESTER..PG’S 62-70 TRENBOLONE AND DERIVATIVES..PG’S 71-78 ESTROGEN CONTROL AND HPTA REGENERATION DRUGS..PG’S 79-94 DIURETICS..PG’S 95-102 THYROID HORMONES ..PG’S 103-116 NON-AAS GROWTH FACTORS AND RELATED SUBSTANCES..PG’S 117-141 OTHER SUBSTANCES..PG’S 142-152 3. REPORTED CYCLES AND EFFECTS.. (Introduction) PG’S 153-159 REPORTED CYCLES AND EFFECTS EXAMPLES (MALE)...PG’S 160-169 REPORTED CYCLES AND EFFECTS EXAMPLES (FEMALE)...PG’S 170-174 REPORTED ADVANCED CYCLES AND EFFECTS-BLITZ CYCLES..PG’S 175-200 (More Reported Cycles and Effects) 4. NUTRITION..PG’S..201-211 5. SUPPLEMENTAL CREATINE..PG’S 212-216 6. REFERENCES AND AVAILABLE LITERATURE..PG’S 217-223 All Rights Reserved CHEMICAL MUSCLE ENHANCEMENT (The Report) and BODYBUILDERS DESK REFERENCE COPYRIGHT ©2002 by AUTHOR L. REA No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical including photocopy, recording, or by any information storage and retrieval system, without the permission in writing of the author and publisher.
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SEAC) Held on 01/10/2019 at Committee Room, Gujarat Pollution Control Board, Sector 10A,Gandhinagar
Minutes of the 554 th meeting ofthe State Level Expert Appraisal Committee (SEAC) held on 01/10/2019 at Committee Room, Gujarat Pollution Control Board, Sector 10A,Gandhinagar. The 554 th meeting of the State Level Expert Appraisal Committee (SEAC) was held on 1st October 2019 at Committee Room, Gujarat Pollution Control Board, Sector 10A, Gandhinagar. Following members attended the meeting: 1. Dr. Dinesh Misra, Chairman, SEAC 2. Shri S. C. Srivastav, Vice Chairman, SEAC 3. Shri Rajesh. I. Shah, Member, SEAC 4. Shri V. N. Patel, Member, SEAC 5. Dr. V. K. Jain, Member, SEAC 6. Shri A. K. Mule, Member, SEAC The regular agenda of Appraisal, Screening & Scoping/ToR, Reconsideration cases were taken up. The Committee considered the applications made by project proponents, additional details submitted as required by the SEAC/SEIAA and details furnished in the Form-1, PFR, EIA-EMP reports. Proposal No. Name and Address of the Unit Remarks 04 SIA/GJ/IND2/29059/2017 M/s. Dev Dyechem Industries EC – Plot No. C-1/324, Phase-I & II GIDC – Reconsideration Naroda, Ahmedabad. • PP remained absent in the EC – Appraisal presentation held on 01/10/2019. • After detailed discussion, Committee decided to defer the proposal and consider the same in one of the upcoming meeting of SEAC. 05 SIA/GJ/IND2/29678/2018 M/s. Apex Pharma EC – C-298/2/4, Saykha Industrial Estate, Reconsideration Saykha, Ta- Vagra, Dist -Bharuch. Category of the unit: 5(f) Project status: New • Project proponent (PP) submitted online application vide no. SIA/GJ/IND2/29678/2018 dated 30/04/19 for obtaining Environmental Clearance.
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2096 Sex Hormones and Their Modulators
2096 Sex Hormones and their Modulators pertensive and potassium-sparing effects might be beneficial in timineralocorticoid effect of drospirenone has also been investi- women requiring treatment for both menopausal symptoms and gated and found to lower blood pressure in postmenopausal 4 hypertension (see also Menopausal Disorders, below). women with treated and untreated hypertension. OCH3 1. Karara AH, et al. Pharmacokinetics and pharmacodynamics of 1. Schürmann R, et al. Estradiol and drospirenone for climacteric drospirenone-estradiol combination hormone therapy product symptoms in postmenopausal women: a double-blind, rand- H3C coadministered with hydrochlorothiazide in hypertensive post- omized, placebo-controlled study of the safety and efficacy of menopausal women. J Clin Pharmacol 2007; 47: 1292–1302. three dose regimens. Climacteric 2004; 7: 189–96. 2. Preston RA, et al. Randomized, placebo-controlled trial of the 2. Whitehead M. Hormone replacement therapy with estradiol and H3C H effects of drospirenone-estradiol on blood pressure and potassi- drospirenone: an overview of the clinical data. J Br Menopause um balance in hypertensive postmenopausal women receiving Soc 2006; 12 (suppl 1): 4–7. hydrochlorothiazide. Menopause 2007; 14: 408–14. 3. Archer DF, et al. Long-term safety of drospirenone-estradiol for H H hormone therapy: a randomized, double-blind, multicenter trial. NSAIDs. Drospirenone has the potential to exacerbate the ef- Menopause 2005; 12: 716–27. O fects of other drugs, such as NSAIDs, that can increase serum 4. Mallareddy M, et al. Drospirenone, a new progestogen, for post- potassium. Licensed product information suggests that a clinical menopausal women with hypertension. Drugs Aging 2007; 24: effect is unlikely in practice, although the use of a number of 453–66.
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NEWS 02 2020 ENG.Qxp Layout 1
Polymers and fluorescence Balance of power 360° drinking water analysis trilogy Fluorescence spectroscopy LCMS-8060NX: performance of industrial base polymers and robustness without Automatic, simultaneous and compromising sensitivity rapid analysis of pesticides and speed CONTENT APPLICATION »Plug und Play« disease screening solution? – The MALDI-8020 in screening for Sickle Cell Disease 4 Customized software solutions for any measurement – Macro programming for Shimadzu UV-Vis and FTIR 8 Ensuring steroid-free food supplements – Identification of steroids in pharmaceuticals and food supplements with LCMS-8045 11 MSn analysis of nonderivatized and Mtpp-derivatized peptides – Two recent studies applying LCMS-IT-TOF instruments 18 Polymers and fluorescence – Part 2: How much fluorescence does a polymer show during quality control? 26 PRODUCTS The balance of power – LCMS-8060NX balances enhanced performance and robustness 7 360° drinking water analysis: Episode 2 – Automatic, simul- taneous and rapid analysis of pesticides in drinking water by online SPE and UHPLC-MS/MS 14 Versatile testing tool for the automotive industry – Enrico Davoli with the PESI-MS system (research-use only [RUO] instrument) New HMV-G3 Series 17 No more headaches! A guide to choosing the perfect C18 column 22 Validated method for monoclonal antibody drugs – Assessment of the nSMOL methodology in Global solution through the validation of bevacizumab in human serum 24 global collaboration LATEST NEWS Global solution through global collaboration – Shimadzu Cancer diagnosis:
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EXECUTIVE SUMMARY Steroids
EXECUTIVE SUMMARY PREFACE M/s Ratantray Pharmaceuticals Pvt. Ltd. is proposing a project for manufacturing of Vitamins, Steroids & Hormones. SITE DESCRIPTION The said project will come up at H1-174 RIICO, Shree Khatushyam Ji Industrial Area, Reengus, District-Sikar, Rajasthan. The total land available is 500 square metre. The complete land is under acquisition. PROJECTDESCRIPTION M/s Ratantray Pharmaceuticals Pvt. Ltd. is proposing a project for manufacturing of Vitamins, Steroids & Hormones. As per EIA Notification dated 14th Sept., 2006 and amended from time to time, the proposed project falls under Category “B”, Project or Activity 5(f) Synthetic organic chemical Industry. The project is submitted at SEIAA Rajasthan as the proposed project is in notified industrial area. The details of Raw materials are as shown in the table below: Table-1 List of Raw Material S. No. Raw Material Unit Quantity Standard Per Month Per Year (5.0kg batch size) (110kg/month) (Kg) 1 Cyanocobalamin Kg 5.00 100 1200 2 Methyl Iodide Kg 4.50 90 1080 3 Sodium Kg 5.50 110 1320 Borohydride 4 Chloroform Kg 98.00 1960 23520 5 Acetone Kg 60.00 1200 14400 6 Phenol Kg 25.00 500 6000 7 Methanol Kg 13.00 260 3120 The details of Raw materials are as shown in the table below: Table-2 List of Products S. No. Vitamins 1 Methylcobalamin ( Vitamin B12) 2 Hydroxocobalamin Acetate 3 Alfacalcidol (Vitamin D) 4 Ascorbic Acid (Vitamin C) 5 Calcitriol (Vitamin D3) 6 Ergocalciferol (Vitamin D2) 7 Paricalcitol (Vitamin D2) 8 Pyridoxal 5 Phosphate (Vitamin B6) Steroids 1 | Page 1 Beclomethasone
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Injectable Steroids Oral Steroids Post Cycle Therapy Fat Burners Manufacturers Contact Us
Blog Shopping Cart Wishlist My Account Checkout Search $0.00 Menu STEROIDS SHOP INJECTABLE STEROIDS ORAL STEROIDS POST CYCLE THERAPY FAT BURNERS MANUFACTURERS CONTACT US Injectable Steroids Shop Injectable Steroids SORT BY POPULARITY Search SOLD OUT INJECTABLE STEROIDS Deca Durabolin Equipoise HGH Masteron NPP INJECTABLE STEROIDS Parabolan Androxine $90.00 Primobolan Depot Sustanon 250 Testosterone Cypionate Testosterone Enanthate Testosterone Propionate Testosterone Suspension Trenbolone Acetate Trenbolone Enanthate Trenbolone Suspension Tri Tren Winstrol Depot ORAL STEROIDS INJECTABLE STEROIDS Anadrol Aquaviron Anavar $66.00 Dianabol Halotestin Methyltrienolone Moda됍nil Primobolan Proviron Superdrol Testosterone Undecanoate Turinabol Winstrol POST CYCLE THERAPY Anastrozole EQUIPOISE Boldebolin Cabergoline $60.00 Clomid Exemestane HCG HMG Letrozole Nolvadex FAT BURNERS Clenbuterol Cytomel T3 MANUFACTURERS EQUIPOISE Alpha Pharma Boldebolin (vial) Eminence Labs $55.00 Maxtreme Pharma SOLD OUT EQUIPOISE BoldePrime $69.00 EQUIPOISE Bold-Max $73.00 SOLD OUT EQUIPOISE Bold-One $39.00 SOLD OUT INJECTABLE STEROIDS CypoPrime $43.00 SOLD OUT DECA DURABOLIN DecaPrime $54.00 INJECTABLE STEROIDS Alphabolin $62.00 INJECTABLE STEROIDS Alphabolin (vial) $125.00 SOLD OUT INJECTABLE STEROIDS EnaPrime $43.00 HGH Eutropin 4 IU $55.00 HGH Humatrope $550.00 INJECTABLE STEROIDS Induject-250 $59.00 INJECTABLE STEROIDS Induject-250 (vial) $59.00 SOLD OUT INJECTABLE STEROIDS DrostoPrime $72.00 INJECTABLE STEROIDS
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Recent Advances in the Analysis of Steroid Hormones and Related Drugs
ANALYTICAL SCIENCES MAY 2004, VOL. 20 767 2004 © The Japan Society for Analytical Chemistry Reviews Recent Advances in the Analysis of Steroid Hormones and Related Drugs Sándor GÖRÖG Gedeon Richter Ltd., P.O.B. 27, H-1475 Budapest, Hungary The development during the last 15 years and the state-of-the-art in the analysis of bulk steroid hormone drugs and hormone-like structures and pharmaceutical formulations made thereof are summarized. Other steroids (sterols, bile acids, cardiac glycosides, vitamins D) as well as biological-clinical aspects and pharmacokinetic and metabolic studies are excluded from this review. The state-of-the-art is summarized based on comparisons of monographs in the latest editions of the European Pharmacopoeia, United States Pharmacopoeia and the Japanese Pharmacopoeia. This is followed by sections dealing with new developments in the methodology for the fields of spectroscopic and spectrophotometric, chromatographic, electrophoretic and hyphenated techniques as well electroanalytical methods. The review is terminated by two problem-oriented sections: examples on impurity and degradation profiling as well as enantiomeric analysis. (Received January 14, 2004; Accepted February 2, 2004) 1 Introduction 767 4·3 Supercritical fluid chromatography (SFC) 2 Steroid Hormone Drugs in Pharmacopoeias 768 4·4 High-performance liquid chromatography 2·1 Assay of bulk drug materials (HPLC) and HPLC-MS 2·2 Related impurities test of bulk drug materials 5 Electrophoretic and Related Methods 776 2·3 Assay of steroid hormone formulations
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Influence of Androgens on Circulating Adiponectin in Male and Female Rodents
Influence of Androgens on Circulating Adiponectin in Male and Female Rodents Joshua F. Yarrow1,2*, Luke A. Beggs1,2, Christine F. Conover1, Sean C. McCoy1, Darren T. Beck3, Stephen E. Borst3,2 1 Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida, United States of America, 2 Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, Florida, United States of America, 3 Malcom Randall Veterans Affairs Medical Center, Geriatrics Research, Education, and Clinical Center (GRECC), Gainesville, Florida, United States of America Abstract Several endocrine factors, including sex-steroid hormones are known to influence adiponectin secretion. Our purpose was to evaluate the influence of testosterone and of the synthetic non-aromatizable/non-5a reducible androgen 17b- hydroxyestra-4,9,11-trien-3-one (trenbolone) on circulating adiponectin and adiponectin protein expression within visceral fat. Young male and female F344 rats underwent sham surgery (SHAM), gonadectomy (GX), or GX plus supraphysiologic testosterone-enanthate (TE) administration. Total circulating adiponectin was 39% higher in intact SHAM females than SHAM males (p,0.05). GX increased total adiponectin by 29–34% in both sexes (p,0.05), while TE reduced adiponectin to concentrations that were 46–53% below respective SHAMs (p#0.001) and ablated the difference in adiponectin between sexes. No differences in high molecular weight (HMW) adiponectin were observed between sexes or treatments. Adiponectin concentrations were highly and negatively associated with serum testosterone (males: r = 20.746 and females: r=20.742, p#0.001); however, no association was present between adiponectin and estradiol. In separate experiments, trenbolone-enanthate (TREN) prevented the GX-induced increase in serum adiponectin (p#0.001) in young animals, with Low-dose TREN restoring adiponectin to the level of SHAMs and higher doses of TREN reducing adiponectin to below SHAM concentrations (p#0.001).
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Hepatotoxicity Associated with Illicit Use of Anabolic Androgenic Steroids in Doping
Eur opean Rev iew for Med ical and Pharmacol ogical Sci ences 2017; 21 (1 Suppl): 7-16 Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping R. SOLIMINI, M.C. ROTOLO, L. MASTROBATTISTA, C. MORTALI, A. MINUTILLO, S. PICHINI, R. PACIFICI, I. PALMI Department of Therapeutic Research and Medicines Evaluation, Drug Abuse and Doping Unit, Istituto Superiore di Sanità, Rome, Italy Abstract. – Anabolic Androgenic Steroids Since then , several synthetic analogs of testos - (AAS) abuse and misuse is nowadays a harmful terone, known as Anabolic Androgenic Steroids habit involving both professional or recreational (AAS) or designer steroids (e.g . methyltestos - athletes, as well as general population. AAS are also frequently present in over-the-counter di - terone in 1935 , nandrolone in 1950 and 1953, etary supplements without being declared in the testosterone esters from mid-1950s, stanozolol list of ingredients, leaving consumers unaware and oxymetholone in 1959 , oxandrolone in 1962) of the risks of adverse effects. Indeed, health have been produced in the attempt to minimize risks of AAS consumption in pharmaceutical the androgenic effects and improve the anabolic preparations or dietary complements seem still ones 1,2,7-9 . However , a successful complete sepa - underestimated and under-reported. The variety of complications due to AAS misuse involves ration of the anabolic and the androgenic proper - cardiovascular, central nervous, musculoskeletal ties has never been realized in the synthetic de - and genitourinary systems of both males and fe - rivatives of testosterone 1,2,10,11 . Among those, nan - males; psychiatric and behavioral effects, dam - drolone was the first compound which showed a ages to metabolic system, skin and mainly liver.
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