DOCSLIB.ORG

Scientific Articles Published by H.C.Hemker (Selection, Some Key Articles in Bold)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Scientific Articles Published by H.C.Hemker (Selection, Some Key Articles in Bold) Scientific Articles published by H.C.Hemker (selection, some key articles in bold). References 1. Thrombin generation and plasma dilution. Hemker, H. C., & De Smedt, E. (2010). American Journal of Clinical Pathology, 133(1), 163. 2. The technique of measuring thrombin generation with fluorogenic substrates: 3. the effects of sample dilution. De Smedt, E., Wagenvoord, R., & Hemker, H. C. (2009). Thrombosis and Haemostasis, 101(1), 165-170. 3. The technique of measuring thrombin generation with fluorescent substrates: 4. the H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration. Hemker, H. C., Hemker, P. W., & Al Dieri, R. (2009). Thrombosis and Haemostasis, 101(1), 171-177. Erratum: Thrombosis and Haemostasis, 101(2), 412. 4. The technique of measuring thrombin generation with fluorogenic substrates: I. necessity of adequate calibration. De Smedt, E., Al Dieri, R., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., & Hemker, H. C. (2008). Thrombosis and Haemostasis, 100(2), 343-349. 5. Linear diffusion of thrombin and factor xa along the heparin molecule explains the effects of extended heparin chain lengths. Wagenvoord, R., Al Dieri, R., van Dedem, G., Béguin, S., & Hemker, H. C. (2008). Thrombosis Research, 122(2), 237-245. 6. Thrombin generation in whole blood. Al Dieri, R., & Hemker, C. H. (2008). British Journal of Haematology, 141(6), 895. 7. Recollections on thrombin generation. Hemker, H. C. (2008). Journal of Thrombosis and Haemostasis, 6(2), 219-226. 8. Thrombin generation and the search for the ideal antithrombotic drug. [La génération de la thrombine et la recherche du médicament antithrombotique idéal] Hemker, H. C., Al Dieri, R., & Béguin, S. (2008). Sang Thrombose Vaisseaux, 20(SPEC. ISS.), 40-45. 9. Decorticated thrombinography. [La thrombinographie décortiquée] Béguin, S., Al Diéri, R., & Hemker, H. C. (2008). Sang Thrombose Vaisseaux, 20(SPEC. ISS.), 33-34. 10. Thrombin-generating capacity in patients with von willebrand's disease. Haematologica, 92(12), 1639-1646. Rugeri, L., Beguin, S., Hemker, C., Bordet, J. -., Fleury, R., Chatard, B., et al. (2007). 11. The contribution of α2-macroglobulin thrombin to the endogenous thrombin potential [5]. Hemker, H. C., De Smedt, E., & Al Dieri, R. (2007). British Journal of Haematology, 139(3), 513. 12. Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin. Vrij, A. A., Oberndorff-Klein-Woolthuis, A., Dijkstra, G., de Jong, A. E., Wagenvoord, R., Hemker, H. C., et al. (2007). Journal of Thrombosis and Thrombolysis, 24(2), 175-182. 13. The initiation phase - A review of old (clotting-) times. Hemker, H. C. (2007). Thrombosis and Haemostasis, 98(1), 20-23. 14. Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system. Eilertsen, A. L., Liestøl, S., Mowinckel, M. -., Hemker, H. C., & Sandset, P. -. (2007). Thrombosis and Haemostasis, 97(6), 938-943. 15. Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis. De Bièvre, M. A., Vrij, A. A., Schoon, E. J., Dijkstra, G., De Jong, A. E., Oberndorff-Klein Woolthuis, A. H., et al. (2007). Inflammatory Bowel Diseases, 13(6), 753-758. 16. Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk. Lecompte, T., Wahl, D., Perret-Guillaume, C., Hemker, H. C., Lacolley, P., & Regnauli, V. (2007). Haematologica, 92(5), 714-715. 17. Caution in the interpretation of continuous thrombin generation assays: A rebuttal [11]. Hemker, H. C., & de Smedt, E. (2007). Journal of Thrombosis and Haemostasis, 5(5), 1085-1087. 18. Thrombin generation, a function test of the haemostatic-thrombotic system. Hemker, H. C., Al Dieri, R., De Smedt, E., & Béguin, S. (2006). Thrombosis and Haemostasis, 96(5), 553-561. 19. Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. De Nanteuil, G., Gloanec, P., Béguin, S., Giesen, P. L. A., Hemker, H. C., Mennecier, P., et al. (2006). Journal of Medicinal Chemistry, 49(17), 5047-5050. 20. New approaches for measuring coagulation. Barrowcliffe, T. W., Cattaneo, M., Podda, G. M., Bucciarelli, P., Lussana, F., Lecchi, A., et al. (2006). Haemophilia, 12(SUPPL. 3), 76-81. 21. The limits of simulation of the clotting system. Wagenvoord, R., Hemker, P. W., & Hemker, H. C. (2006). Journal of Thrombosis and Haemostasis, 4(6), 1331-1338. 22. Age-dependency of thrombin generation. Hemker, H. C., & Al Dieri, R. (2006). Thrombosis and Haemostasis, 95(5), 756-757. 23. Mathematical and biological models of blood coagulation. A rebuttal [16]. Hemker, H. C., De Smedt, E., & Hemker, P. W. (2006). Journal of Thrombosis and Haemostasis, 4(3), 710-711. 24. Good mathematical practice: Simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection. Hemker, H. C., & Ataullakhanov, F. I. (2006). Pathophysiology of Haemostasis and Thrombosis, 34(2-3), 55-57. 25. Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight. Al Dieri, R., Alban, S., Béuin, S., & Hemker, H. C. (2006). Journal of Thrombosis and Haemostasis, 4(1), 83-89. 26. During coagulation, thrombin generation shifts from chemical to diffusional control [1]. Hemker, H. C., De Smedt, E., & Hemker, P. W. (2005). Journal of Thrombosis and Haemostasis, 3(11), 2399- 2400. 27. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Dargaud, Y., Béguin, S., Lienhart, A., Al Dieri, R., Trzeciak, C., Bordet, J. C., et al. (2005). Thrombosis and Haemostasis, 93(3), 475-480. 28. Laboratory monitoring of low-molecular-weight heparin therapy - part II. Hemker, H. C., Al Dieri, R., Béguin, S., Boneu, B., Monreal, M., & Barrowcliffe, T. W. (2005). Journal of Thrombosis and Haemostasis, 3(3), 571- 576. 29. Laboratory monitoring of low-molecular-weight heparin therapy--part II. monitoring LMWH therapy? for the moment a non-question. Hemker, H. C., Al Dieri, R., & Béguin, S. (2005). Journal of Thrombosis and Haemostasis : JTH, 3(3), 571-573. 30. Calibrated automated thrombinography (CAT). Hemker, H. C. (2005). Thrombosis Research, 115(3), 255. 31. Phenotyping the haemostatic system by thrombography - potential for the estimation of thrombotic risk. Regnault, V., Hemker, H. C., Wahl, D., & Lecompte, T. (2004). Thrombosis Research, 114(5-6 SPEC. ISS.), 539-545. 32. Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time. Al Dieri, R., Alban, S., Béguin, S., & Hemker, H. C. (2004). Journal of Thrombosis and Haemostasis, 2(8), 1395-1401. 33. Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available. Wielders, S. J. H., Béguin, S., Hemker, H. C., & Lindhout, T. (2004). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(6), 1138-1142. 34. Thrombin generation assays: Accruing clinical relevance. Hemker, H. C., Al Dieri, R., & Béguin, S. (2004). Current Opinion in Hematology, 11(3), 170-175. 35. The love of the artist for his model of thrombin generation. Hemker, H. C., & Béguin, S. (2004). Journal of Thrombosis and Haemostasis, 2(3), 400-401. 36. Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: Subject-dependent variation in thrombogram characteristics. Vanschoonbeek, K., Feijge, M. A. H., Van Kampen, R. J. W., Kenis, H., Hemker, H. C., Giesen, P. L. A., et al. (2004). Journal of Thrombosis and Haemostasis, 2(3), 476-484. 37. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPlb- dependent process, defective in bernard-soulier syndrome. Béguin, S., Keularts, I., Al Dieri, R., Bellucci, S., Caen, J., & Hemker, H. C. (2004). Journal of Thrombosis and Haemostasis, 2(1), 170- 176. 38. Calibrated automated thrombin generation measurement in clotting plasma. Hemker, H. C., Giesen, P., Al Dieri, R., Regnault, V., De Smedt, E., Wagenvoord, R., et al. (2003). Pathophysiology of Haemostasis and Thrombosis, 33(1), 4-15. 39. Pathophysiology of haemostasis and thrombosis: Editorial. Hemker, H. C., & Rosing, J. (2003). Pathophysiology of Haemostasis and Thrombosis, 33(1), 1. 40. The Choay domain - the structure responsible for the anticoagulant action of heparins. [Le domaine Choay - La structure responsable de l'activité anticoagulante des héparines] Hemker, H. C., Dieri, R. A., Wagenvoord, R., Béguin, S., & Blancher, M. G. (2003). Bulletin De l'Academie Nationale De Medecine, 187(1), 59-67. 41. Thrombin generation: Old wine into new wineskins(ref. I). Hemker, H. C., & Béguin, S. (2003). Thrombosis and Haemostasis, 90(5), 764-765. 42. Von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. Briedé, J. J., Wielders, S. J., Heemskerk, J. W., Baruch, D., Hemker, H. C., & Lindhout, T. (2003). Journal of Thrombosis and Haemostasis : JTH, 1(3), 559-565. 43. The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets. Al Dieri, R., Béguin, S., & Hemker, H. C. (2003). J Thromb Haemost, 1(2), 269-274. 44. Thrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants. Regnault, V., Béguin, S., Wahl, D.,
Load more

Recommended publications
  • Desmodus Rotundus) Blood Feeding
    toxins Article Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding Rahini Kakumanu 1, Wayne C. Hodgson 1, Ravina Ravi 1, Alejandro Alagon 2, Richard J. Harris 3 , Andreas Brust 4, Paul F. Alewood 4, Barbara K. Kemp-Harper 1,† and Bryan G. Fry 3,*,† 1 Department of Pharmacology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing & Health Sciences, Monash University, Clayton, Victoria 3800, Australia; [email protected] (R.K.); [email protected] (W.C.H.); [email protected] (R.R.); [email protected] (B.K.K.-H.) 2 Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico; [email protected] 3 Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, Queensland 4067, Australia; [email protected] 4 Institute for Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia; [email protected] (A.B.); [email protected] (P.F.A.) * Correspondence: [email protected] † Joint senior authors. Received: 20 November 2018; Accepted: 2 January 2019; Published: 8 January 2019 Abstract: Animals that specialise in blood feeding have particular challenges in obtaining their meal, whereby they impair blood hemostasis by promoting anticoagulation and vasodilation in order to facilitate feeding. These convergent selection pressures have been studied in a number of lineages, ranging from fleas to leeches. However, the vampire bat (Desmondus rotundus) is unstudied in regards to potential vasodilatory mechanisms of their feeding secretions (which are a type of venom). This is despite the intense investigations of their anticoagulant properties which have demonstrated that D.
    [Show full text]
  • Heparin EDTA Patent Application Publication Feb
    US 20110027771 A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0027771 A1 Deng (43) Pub. Date: Feb. 3, 2011 (54) METHODS AND COMPOSITIONS FORCELL Publication Classification STABILIZATION (51) Int. Cl. (75)75) InventorInventor: tDavid Deng,eng, Mountain rView, V1ew,ar. CA C09KCI2N 5/073IS/00 (2006.01)(2010.01) C7H 2L/04 (2006.01) Correspondence Address: CI2O 1/02 (2006.01) WILSON, SONSINI, GOODRICH & ROSATI GOIN 33/48 (2006.01) 650 PAGE MILL ROAD CI2O I/68 (2006.01) PALO ALTO, CA 94304-1050 (US) CI2M I/24 (2006.01) rsr rr (52) U.S. Cl. ............ 435/2; 435/374; 252/397:536/23.1; (73) Assignee: Arts Health, Inc., San Carlos, 435/29: 436/63; 436/94; 435/6: 435/307.1 (21) Appl. No.: 12/847,876 (57) ABSTRACT Fragile cells have value for use in diagnosing many types of (22) Filed: Jul. 30, 2010 conditions. There is a need for compositions that stabilize fragile cells. The stabilization compositions of the provided Related U.S. Application Data inventionallow for the stabilization, enrichment, and analysis (60) Provisional application No. 61/230,638, filed on Jul. of fragile cells, including fetal cells, circulating tumor cells, 31, 2009. and stem cells. 14 w Heparin EDTA Patent Application Publication Feb. 3, 2011 Sheet 1 of 17 US 2011/0027771 A1 FIG. 1 Heparin EDTA Patent Application Publication Feb. 3, 2011 Sheet 2 of 17 US 2011/0027771 A1 FIG. 2 Cell Equivalent/10 ml blood P=0.282 (n=11) 1 hour 6 hours No Composition C Composition C Patent Application Publication Feb.
    [Show full text]
  • A Novel Anticoagulant Protein from Scapharca Broughtonii
    Journal of Biochemistry and Molecular Biology, Vol. 35, No. 2, March 2002, pp. 199-205 © BSRK & Springer-Verlag 2002 A Novel Anticoagulant Protein from Scapharca broughtonii Won-Kyo Jung, Jae-Young Je, Hee-Ju Kim and Se-Kwon Kim* Department of Chemistry, Pukyong National University, Busan 608-737, Korea Received 24 September 2001, Accepted 26 November 2001 An anticoagulant protein was purified from the edible marine organisms have rarely been isolated, except for several portion of a blood ark shell, Scapharca broughtonii, by anticoagulant proteoglycans and polysaccharides from marine ammonium sulfate precipitation and column algae (Chargaff et al., 1936 Kindness et al., 1980; Maimone chromatography on DEAE-Sephadex A-50, Sephadex G- and Tollefsen, 1990; McLellan & Jurd, 1991; Jurd et al., 75, DEAE-Sephacel, and Biogel P-100. In vitro assays with 1995) and ascidian tunic (Lee et al., 1998). human plasma, the anticoagulant from S. broughtonii, During screening of the anticoagulant activity in marine prolonged the activated partial thromboplastin time animals, we recently detected anticoagulant activity from (APTT) and inhibited the factor IX in the intrinsic soluble extracts of the blood ark shell, Scapharca broughtonii. pathway of the blood coagulation cascade. But, the fibrin In the present paper, we report the purification and properties plate assay did not show that the anticoagulant is a of the first anticoagulant protein from marine bivalves. fibrinolytic protease. The molecular mass of the purified S. broughtonii anticoagulant was measured to be about 26.0 Materials and Methods kDa by gel filtration on a Sephadex G-75 column and SDS- PAGE under denaturing conditions.
    [Show full text]
  • View PDF Version
    RSC Advances PAPER View Article Online View Journal | View Issue Interaction of the synthetic antithrombotic peptide P10 with thrombin: a spectroscopy study Cite this: RSC Adv.,2019,9, 18498 Fangyuan Chen, Han Jiang, Wenwei Chen and Guangrong Huang * Thrombin is a critical serine protease in the coagulation system and is widely used as a target protein for antithrombotics. Spectroscopic analysis is a simple and effective method that is used to study the interaction between small molecules and proteins. In this study, the interactions of a potential antithrombotic peptide AGFAGDDAPR (P10) with thrombin were investigated by fluorescence spectroscopy, UV-vis spectroscopy, circular dichroism, Fourier-transform infrared spectroscopy and Raman spectroscopy, respectively. The results showed that the peptide P10 bonded to thrombin via hydrogen bonding and van der Waals forces, resulting in fluorescence quenching. And, the secondary structure of Received 22nd April 2019 thrombin changed, the b-sheet decreased, and the random coil increased. The peptide P10 bonded to Accepted 29th May 2019 proline and lysine, and changed the space structure of thrombin, resulting in inhibition of thrombin activity. DOI: 10.1039/c9ra02994j The results contributed to exploration of the mechanism of this potential antithrombotic drug interaction Creative Commons Attribution 3.0 Unported Licence. rsc.li/rsc-advances with thrombin in order to provide a preliminary understanding of the pharmacodynamic properties of P10. Introduction isolated and identied from natural materials and have demonstrated many biologically active functions such as The coagulation process is a cascade of proteolytic reactions, bacteriostatic, antioxidant, hypotensive, hypoglycemic, etc.10,11 divided into an intrinsic pathway and an extrinsic pathway.
    [Show full text]
  • WO 2011/014741 Al
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 3 February 2011 (03.02.2011) WO 2011/014741 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 5/00 (2006.0 1) C12N 5/02 (2006.0 1) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US2010/043854 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 30 July 2010 (30.07.2010) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, (26) Publication Language: English SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 61/230,638 31 July 2009 (3 1.07.2009) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ARTEMIS HEALTH, INC. [US/US]; 153 1 Industrial ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, Road, San Carlos, CA 94070 (US).
    [Show full text]
  • Dracula's Children: Molecular Evolution of Vampire Bat Venom
    JPROT-01451; No of Pages 17 JOURNAL OF PROTEOMICS XX (2013) XXX– XXX Available online at www.sciencedirect.com www.elsevier.com/locate/jprot 1 Dracula's children: Molecular evolution of vampire bat venom a,1 b,c,1 a,d,1 a,d,e,1 Q12 Dolyce H.W. Low , Kartik Sunagar , Eivind A.B. Undheim , Syed A. Ali , f a a,d d 3 Alejandro C. Alagon , Tim Ruder , Timothy N.W. Jackson , Sandy Pineda Gonzalez , d d b,c a,d,⁎ 4 Glenn F. King , Alun Jones , Agostinho Antunes , Bryan G. Fry 5 aVenom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia 6 bCIMAR/CIIMAR, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Rua dos Bragas, 177, 7 4050-123 Porto, Portugal 8 cDepartamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal 9 dInstitute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia 10 eHEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, 11 Karachi 75270, Pakistan 12 fDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, 13 Av. Universidad 2001, Cuernavaca, Morelos 62210, Mexico 14 1617 ARTICLE INFO ABSTRACT 2218 Article history: While vampire bat oral secretions have been the subject of intense research, efforts have 1923 Received 29 March 2013 concentrated only on two components: DSPA (Desmodus rotundus salivary plasminogen 2024 Accepted 28 May 2013 activator) and Draculin. The molecular evolutionary history of DSPA has been elucidated, 2125 while conversely draculin has long been known from only a very small fragment and thus 26 even the basic protein class was not even established.
    [Show full text]
  • Vascular–Platelet and Plasma Hemostasis Regulators from Bloodsucking Animals
    Biochemistry (Moscow), Vol. 67, No. 1, 2002, pp. 143150. Translated from Biokhimiya, Vol. 67, No. 1, 2002, pp. 167176. Original Russian Text Copyright © 2002 by Basanova, Baskova, Zavalova. REVIEW Vascular–Platelet and Plasma Hemostasis Regulators from Bloodsucking Animals A. V. Basanova1, I. P. Baskova1*, and L. L. Zavalova2 1School of Biology, Lomonosov Moscow State University, Moscow, 119899 Russia; fax: (095) 9391745 2Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. MiklukhoMaklaya 16/10, Moscow, 117997 Russia; fax: (095) 3306538; Email: [email protected] Received June 6, 2001 Revision received July 3, 2001 Abstract—Saliva of bloodsuckers (leeches, insects, ticks, vampire bats) contains various regulators of some hemostatic stages. This review summarizes information on their structural characteristics and mechanisms of action. Most bloodsuckers are shown to inhibit vascular–platelet hemostasis by blocking collageninduced platelet adhesion/aggregation. Plasma hemosta sis is inhibited by blocking activation of factor X or factor Xa directly. Key words: bloodsuckers, leeches, insects, ticks, vascular–platelet hemostasis, platelet adhesion and aggregation, prothrom binase complex, factor Xa Hematophages, i.e., animals adapted during evolu of intrinsic mechanisms of blood coagulation and pro tion to bloodsucking as their exclusive feeding, secrete teins of the prothrombinase complex; 3) regulators of fib compounds blocking the hemostasis of the host. This is an rin formation; these include inhibitors of thrombin and absolute requirement for survival of the bloodsuckers [1]. factor XIIIa, fibrino(geno)lytic enzymes and activators of Therefore, the appearance of antihemostatic and fibri fibrinolysis [2]. nolytic compounds in secretions of hematophages has In this review, we consider only the first two groups evolutionary sense.
    [Show full text]
  • The Role of Bats and Relationships As Reservoirs of Zoonotic Viruses and the Origin of New Coronaviruses
    Forensic Research & Criminology International Journal Literature Review Open Access Spillover: the role of bats and relationships as reservoirs of zoonotic viruses and the origin of new coronaviruses Abstract Volume 8 Issue 5 - 2020 Since recent findings on coronavirus, there are numerous outstanding questions about the 1,2 recent emergence of these viruses, their relationship to bats, environmental issues, gene Diniz Pereira Leite Júnior, Rodrigo Antônio 3 recombinations, reservoirs, evolution and the role of human coronavirus in human infection. Araújo Pires, Elisangela Santana de Oliveira This review aimed to gather information about the possible origin of the new coronavirus Dantas,4 Ronaldo Sousa Pereira,2 Mário (SARS-CoV-2) and its relationship with the alated mammals and the new strains found. Mendes Bonci,1 Regina Teixeira Barbieri Selected studies indicate that SARS-CoV-2 is a chimeric virus between a bat coronavirus Ramos,1 Gisela Lara da Costa,5 Marcia de and a coronavirus of unknown origin. One of the possibilities points to bats as being a Souza Carvalho Melhem,6 Paulo Anselmo reservoir originating from SARS-CoV-2 (COVID-19), transmitting to man via host source. Nunes Felippe,3,7 Claudete Rodrigues Paula1 The records indicate that a recombination between the coronaviruses of pangolins and the 1School of Dentistry, University of São Paulo (USP), SP, Brazil bat coronavirus BatCoV RaTG13 and SARS-CoV-2 human there is a common ancestry 2Specialized Medical Mycology Center, Laboratory Investigation, among these Betacoronaviruses, which were even identified in other mammalian species, Medicine School, Federal University of Mato Grosso (UFMT), named Ptajacu-CoV. Several questions were raised about the artificial origin of the virus by MT, Brazil laboratory manipulation.
    [Show full text]
  • Expression of Biological Activity of Draculin, the Anticoagulant Factor
    Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule Citation for published version (APA): Fernandez, A. Z., Tablante, A., Bartoli, F., Beguin, S., Hemker, H. C., & Apitz-Castro, R. (1998). Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. Biochimica et Biophysica Acta-general Subjects, 1425(2), 291-299. https://doi.org/10.1016/S0304-4165(98)00082-8 Document status and date: Published: 23/10/1998 DOI: 10.1016/S0304-4165(98)00082-8 Document Version: Publisher's PDF, also known as Version of record Please check the document version of this publication: • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.
    [Show full text]
  • An Investigation of Mining Impacts on Bats in South-West England
    An investigation of mining impacts on bats in South-West England Submitted by Emma Theobald to the University of Exeter as a thesis for the degree of Masters by Research in Biological Sciences in March 2018 This thesis is available for Library use on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement. I certify that all material in this thesis which is not my own work has been identified and that no material has previously been submitted and approved for the award of a degree by this or any other University. Signature: …………………………… 1 Acknowledgements: First of all a massive thank you to my research tutors Prof. David Hosken and Dr. Kelly Moyes for introducing me ‘bat world’ and for their continued guidance and support, also to Prof. Patrick Foster for his insight into the mining industry. I am very grateful to Wolf Minerals for providing the funding for this research and would like to thank Jess Easterbrook and Hannah Clarke of the Environmental Team and Michel Hughes for introducing me to the Drakelands site and answering my questions. I really appreciate the cooperation of the landowners who let me climb fences and wander through their fields and to set up detectors (David Cobbold in particular) - without your permission this research would not have been possible. Last but not least, I would like to thank Reece and my family and friends for their support and encouragement and for listening to my bat chat over the past year and a half! 2 An investigation of mining impacts on bats in South-West England Abstract: The extraction of minerals through open-pit mining can result in sudden and extensive land use change, often posing threats to local biodiversity.
    [Show full text]
  • Purification and Partial Characterization of Draculin, the Anticoagulant Factor Present in the Saliva of Vampire Bats (Desmodus Rotundus)
    Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus) Citation for published version (APA): Apitz-Castro, R., Beguin, S., Tablante, A., Bartoli, F., Holt, J. C., & Hemker, H. C. (1995). Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus rotundus). Thrombosis and Haemostasis, 73(1), 94-100. https://doi.org/10.1055/s-0038- 1653731 Document status and date: Published: 01/01/1995 DOI: 10.1055/s-0038-1653731 Document Version: Publisher's PDF, also known as Version of record Please check the document version of this publication: • A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.
    [Show full text]
  • Oup Biohor Hzw015 1..20 ++
    BioscienceHorizons Volume 10 2017 10.1093/biohorizons/hzw015 ................................................................................................................................................................. Review article Evolution of salivary secretions in haematophagous animals Francesca L. Ware* and Martin R. Luck School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicester LE12 5RD, UK *Corresponding author: 27 Braishfield Gardens, Bournemouth, Dorset BH8 0QA, UK. Email: [email protected] Supervisor: Prof. Martin Luck, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicester LE12 5RD, UK. ................................................................................................................................................................. Haemostasis is the prevention of blood fluidity in vertebrates and is the first stage of wound healing. Haematophagous animals use the blood of vertebrates as their sole source of nutrition and have evolved many salivary constituents to counteract the haemostatic response of their prey. These animals and their saliva have been studied for many years, with some applications in medicine. The purpose of this study is to compare the salivary constituents of leeches (Hirudinae), ticks (Argasidae and Ixodidae) and vampire bats (Desmodontinae) and to consider their evolutionary origin. Salivary constituents include plasminogen activa- tors (PAs), anticoagulants (activated factor X, FXa; inhibitors),
    [Show full text]