Scientific Articles published by H.C.Hemker (selection, some key articles in bold). References 1. Thrombin generation and plasma dilution. Hemker, H. C., & De Smedt, E. (2010). American Journal of Clinical Pathology, 133(1), 163. 2. The technique of measuring thrombin generation with fluorogenic substrates: 3. the effects of sample dilution. De Smedt, E., Wagenvoord, R., & Hemker, H. C. (2009). Thrombosis and Haemostasis, 101(1), 165-170. 3. The technique of measuring thrombin generation with fluorescent substrates: 4. the H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration. Hemker, H. C., Hemker, P. W., & Al Dieri, R. (2009). Thrombosis and Haemostasis, 101(1), 171-177. Erratum: Thrombosis and Haemostasis, 101(2), 412. 4. The technique of measuring thrombin generation with fluorogenic substrates: I. necessity of adequate calibration. De Smedt, E., Al Dieri, R., Spronk, H. M. H., Hamulyak, K., Ten Cate, H., & Hemker, H. C. (2008). Thrombosis and Haemostasis, 100(2), 343-349. 5. Linear diffusion of thrombin and factor xa along the heparin molecule explains the effects of extended heparin chain lengths. Wagenvoord, R., Al Dieri, R., van Dedem, G., Béguin, S., & Hemker, H. C. (2008). Thrombosis Research, 122(2), 237-245. 6. Thrombin generation in whole blood. Al Dieri, R., & Hemker, C. H. (2008). British Journal of Haematology, 141(6), 895. 7. Recollections on thrombin generation. Hemker, H. C. (2008). Journal of Thrombosis and Haemostasis, 6(2), 219-226. 8. Thrombin generation and the search for the ideal antithrombotic drug. [La génération de la thrombine et la recherche du médicament antithrombotique idéal] Hemker, H. C., Al Dieri, R., & Béguin, S. (2008). Sang Thrombose Vaisseaux, 20(SPEC. ISS.), 40-45. 9. Decorticated thrombinography. [La thrombinographie décortiquée] Béguin, S., Al Diéri, R., & Hemker, H. C. (2008). Sang Thrombose Vaisseaux, 20(SPEC. ISS.), 33-34. 10. Thrombin-generating capacity in patients with von willebrand's disease. Haematologica, 92(12), 1639-1646. Rugeri, L., Beguin, S., Hemker, C., Bordet, J. -., Fleury, R., Chatard, B., et al. (2007). 11. The contribution of α2-macroglobulin thrombin to the endogenous thrombin potential [5]. Hemker, H. C., De Smedt, E., & Al Dieri, R. (2007). British Journal of Haematology, 139(3), 513. 12. Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin. Vrij, A. A., Oberndorff-Klein-Woolthuis, A., Dijkstra, G., de Jong, A. E., Wagenvoord, R., Hemker, H. C., et al. (2007). Journal of Thrombosis and Thrombolysis, 24(2), 175-182. 13. The initiation phase - A review of old (clotting-) times. Hemker, H. C. (2007). Thrombosis and Haemostasis, 98(1), 20-23. 14. Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system. Eilertsen, A. L., Liestøl, S., Mowinckel, M. -., Hemker, H. C., & Sandset, P. -. (2007). Thrombosis and Haemostasis, 97(6), 938-943. 15. Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis. De Bièvre, M. A., Vrij, A. A., Schoon, E. J., Dijkstra, G., De Jong, A. E., Oberndorff-Klein Woolthuis, A. H., et al. (2007). Inflammatory Bowel Diseases, 13(6), 753-758. 16. Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk. Lecompte, T., Wahl, D., Perret-Guillaume, C., Hemker, H. C., Lacolley, P., & Regnauli, V. (2007). Haematologica, 92(5), 714-715. 17. Caution in the interpretation of continuous thrombin generation assays: A rebuttal [11]. Hemker, H. C., & de Smedt, E. (2007). Journal of Thrombosis and Haemostasis, 5(5), 1085-1087. 18. Thrombin generation, a function test of the haemostatic-thrombotic system. Hemker, H. C., Al Dieri, R., De Smedt, E., & Béguin, S. (2006). Thrombosis and Haemostasis, 96(5), 553-561. 19. Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. De Nanteuil, G., Gloanec, P., Béguin, S., Giesen, P. L. A., Hemker, H. C., Mennecier, P., et al. (2006). Journal of Medicinal Chemistry, 49(17), 5047-5050. 20. New approaches for measuring coagulation. Barrowcliffe, T. W., Cattaneo, M., Podda, G. M., Bucciarelli, P., Lussana, F., Lecchi, A., et al. (2006). Haemophilia, 12(SUPPL. 3), 76-81. 21. The limits of simulation of the clotting system. Wagenvoord, R., Hemker, P. W., & Hemker, H. C. (2006). Journal of Thrombosis and Haemostasis, 4(6), 1331-1338. 22. Age-dependency of thrombin generation. Hemker, H. C., & Al Dieri, R. (2006). Thrombosis and Haemostasis, 95(5), 756-757. 23. Mathematical and biological models of blood coagulation. A rebuttal [16]. Hemker, H. C., De Smedt, E., & Hemker, P. W. (2006). Journal of Thrombosis and Haemostasis, 4(3), 710-711. 24. Good mathematical practice: Simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection. Hemker, H. C., & Ataullakhanov, F. I. (2006). Pathophysiology of Haemostasis and Thrombosis, 34(2-3), 55-57. 25. Fixed dosage of low-molecular-weight heparins causes large individual variation in coagulability, only partly correlated to body weight. Al Dieri, R., Alban, S., Béuin, S., & Hemker, H. C. (2006). Journal of Thrombosis and Haemostasis, 4(1), 83-89. 26. During coagulation, thrombin generation shifts from chemical to diffusional control [1]. Hemker, H. C., De Smedt, E., & Hemker, P. W. (2005). Journal of Thrombosis and Haemostasis, 3(11), 2399- 2400. 27. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Dargaud, Y., Béguin, S., Lienhart, A., Al Dieri, R., Trzeciak, C., Bordet, J. C., et al. (2005). Thrombosis and Haemostasis, 93(3), 475-480. 28. Laboratory monitoring of low-molecular-weight heparin therapy - part II. Hemker, H. C., Al Dieri, R., Béguin, S., Boneu, B., Monreal, M., & Barrowcliffe, T. W. (2005). Journal of Thrombosis and Haemostasis, 3(3), 571- 576. 29. Laboratory monitoring of low-molecular-weight heparin therapy--part II. monitoring LMWH therapy? for the moment a non-question. Hemker, H. C., Al Dieri, R., & Béguin, S. (2005). Journal of Thrombosis and Haemostasis : JTH, 3(3), 571-573. 30. Calibrated automated thrombinography (CAT). Hemker, H. C. (2005). Thrombosis Research, 115(3), 255. 31. Phenotyping the haemostatic system by thrombography - potential for the estimation of thrombotic risk. Regnault, V., Hemker, H. C., Wahl, D., & Lecompte, T. (2004). Thrombosis Research, 114(5-6 SPEC. ISS.), 539-545. 32. Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time. Al Dieri, R., Alban, S., Béguin, S., & Hemker, H. C. (2004). Journal of Thrombosis and Haemostasis, 2(8), 1395-1401. 33. Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available. Wielders, S. J. H., Béguin, S., Hemker, H. C., & Lindhout, T. (2004). Arteriosclerosis, Thrombosis, and Vascular Biology, 24(6), 1138-1142. 34. Thrombin generation assays: Accruing clinical relevance. Hemker, H. C., Al Dieri, R., & Béguin, S. (2004). Current Opinion in Hematology, 11(3), 170-175. 35. The love of the artist for his model of thrombin generation. Hemker, H. C., & Béguin, S. (2004). Journal of Thrombosis and Haemostasis, 2(3), 400-401. 36. Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: Subject-dependent variation in thrombogram characteristics. Vanschoonbeek, K., Feijge, M. A. H., Van Kampen, R. J. W., Kenis, H., Hemker, H. C., Giesen, P. L. A., et al. (2004). Journal of Thrombosis and Haemostasis, 2(3), 476-484. 37. Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPlb- dependent process, defective in bernard-soulier syndrome. Béguin, S., Keularts, I., Al Dieri, R., Bellucci, S., Caen, J., & Hemker, H. C. (2004). Journal of Thrombosis and Haemostasis, 2(1), 170- 176. 38. Calibrated automated thrombin generation measurement in clotting plasma. Hemker, H. C., Giesen, P., Al Dieri, R., Regnault, V., De Smedt, E., Wagenvoord, R., et al. (2003). Pathophysiology of Haemostasis and Thrombosis, 33(1), 4-15. 39. Pathophysiology of haemostasis and thrombosis: Editorial. Hemker, H. C., & Rosing, J. (2003). Pathophysiology of Haemostasis and Thrombosis, 33(1), 1. 40. The Choay domain - the structure responsible for the anticoagulant action of heparins. [Le domaine Choay - La structure responsable de l'activité anticoagulante des héparines] Hemker, H. C., Dieri, R. A., Wagenvoord, R., Béguin, S., & Blancher, M. G. (2003). Bulletin De l'Academie Nationale De Medecine, 187(1), 59-67. 41. Thrombin generation: Old wine into new wineskins(ref. I). Hemker, H. C., & Béguin, S. (2003). Thrombosis and Haemostasis, 90(5), 764-765. 42. Von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets. Briedé, J. J., Wielders, S. J., Heemskerk, J. W., Baruch, D., Hemker, H. C., & Lindhout, T. (2003). Journal of Thrombosis and Haemostasis : JTH, 1(3), 559-565. 43. The ionic contrast medium ioxaglate interferes with thrombin-mediated feedback activation of factor V, factor VIII and platelets. Al Dieri, R., Béguin, S., & Hemker, H. C. (2003). J Thromb Haemost, 1(2), 269-274. 44. Thrombinography shows acquired resistance to activated protein C in patients with lupus anticoagulants. Regnault, V., Béguin, S., Wahl, D.,