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Vectorborne Zoonoses: Break-Out Session Epidemiology and Laboratory Capacity Workshop – Oct
Texas Department of State Health Services Vectorborne Zoonoses: Break-out Session Epidemiology and Laboratory Capacity Workshop – Oct. 2018 DSHS Zoonosis Control Branch Session Topics Texas Department of State Health Services • NEDSS case investigation tips • Lyme disease • Rickettsial diseases • Arboviral diseases ELC 2018 - Vectorborne Diseases 2 Texas Department of State Health Services Don’t be a Reject! Helpful tips to keep your notification from being rejected ELC breakout session October 3, 2018 Kamesha Owens, MPH Zoonosis Control Branch Texas Department of State Health Services Objectives • Rejection Criteria • How to document in NBS (NEDSS) • How to Report Texas Department of State Health Services 10/3/2018 ELC 2018 - Vectorborne Diseases 4 Rejection Criteria Texas Department of State Health Services Missing/incorrect information: • Incorrect case status or condition selected • Full Name • Date of Birth • Address • County • Missing laboratory data 10/3/2018 ELC 2018 - Vectorborne Diseases 5 Rejection Criteria continued Texas Department of State Health Services • Inconsistent information • e.g. Report date is a week before onset date • Case investigation form not received by ZCB within 14 days of notification • ZCB recommends that notification not be created until the case is closed and the investigation form has been submitted 10/3/2018 ELC 2018 - Vectorborne Diseases 6 Rejection Criteria continued Texas Department of State Health Services • Condition-specific information necessary to report the case is missing: • Travel history for Zika and other non-endemic conditions • Evidence of neurological disease for WNND case • Supporting documentation for Lyme disease case determination 10/3/2018 ELC 2018 - Vectorborne Diseases 7 How to Document in NBS (NEDSS) Do Don’t Add detailed comments in designated Leave us guessing! comments box under case info tab. -
Melioidosis: a Clinical Model for Gram-Negative Sepsis
J. Med. Microbiol. Ð Vol. 50 2001), 657±658 # 2001 The Pathological Society of Great Britain and Ireland ISSN 0022-2615 EDITORIAL Melioidosis: a clinical model for gram-negative sepsis The recently published study of recombinant human clinical sepsis model over the current heterogeneous activated protein C drotrecogin-á, Eli Lilly, Indiana- clinical trials. Our knowledge of melioidosis and its polis, IN, USA) in severe sepsis makes welcome causative organism, Burkholderia formerly Pseudomo- reading. At last a clinical trial of an augmentative nas) pseudomallei, has expanded considerably over the therapy in severe sepsis has managed to show a last 15 years. Melioidosis was originally described in mortality bene®t from the trial agent [1]. Most studies Myanmar then Burma) in 1911 and came to of augmentative treatments in serious sepsis have failed prominence during the Vietnam con¯ict, when French to show clear bene®t. Sepsis studies commonly involve and American soldiers became infected. It has been a syndrome caused by a myriad of organisms, occurring described in most countries of south-east Asia, in a very heterogeneous group of patients, who may be including the Peoples Republic of China and the Lao enrolled in one of several centres. This introduces PDR [5], but Thailand has the greatest reported disease multiple confounding factors. Agood model for clinical burden [6]. It is also endemic to northern Australia [7]. sepsis studies would ideally cause disease in a relatively Understanding of the epidemiology of the disease has homogeneous population, be acquired in a community been improved by the demonstration of two pheno- setting, present in large numbers to a single institution, typically similar but genetically distinct biotypes in the be caused by a single organism, and ordinarily result in environment [8], only one of which appears to be a substantial mortality rate. -
Kellie ID Emergencies.Pptx
4/24/11 ID Alert! recognizing rapidly fatal infections Susan M. Kellie, MD, MPH Professor of Medicine Division of Infectious Diseases, UNMSOM Hospital Epidemiologist UNMHSC and NMVAHCS Fever and…. Rash and altered mental status Rash Muscle pain Lymphadenopathy Hypotension Shortness of breath Recent travel Abdominal pain and diarrhea Case 1. The cross-country trucker A 30 year-old trucker driving from Oklahoma to California is hospitalized in Deming with fever and headache He is treated with broad-spectrum antibiotics, but deteriorates with obtundation, low platelet count, and a centrifugal petechial rash and is transferred to UNMH 1 4/24/11 What is your diagnosis? What is the differential diagnosis of fever and headache with petechial rash? (in the US) Tickborne rickettsioses ◦ RMSF Bacteria ◦ Neisseria meningitidis Key diagnosis in this case: “doxycycline deficiency” Key vector-borne rickettsioses treated with doxycycline: RMSF-case-fatality 5-10% ◦ Fever, nausea, vomiting, myalgia, anorexia and headache ◦ Maculopapular rash progresses to petechial after 2-4 days of fever ◦ Occasionally without rash Human granulocytotropic anaplasmosis (HGA): case-fatality<1% Human monocytotropic ehrlichiosis (HME): case fatality 2-3% 2 4/24/11 Lab clues in rickettsioses The total white blood cell (WBC) count is typicallynormal in patients with RMSF, but increased numbers of immature bands are generally observed. Thrombocytopenia, mild elevations in hepatic transaminases, and hyponatremia might be observed with RMSF whereas leukopenia -
Pearls: Infectious Diseases
Pearls: Infectious Diseases Karen L. Roos, M.D.1 ABSTRACT Neurologists have a great deal of knowledge of the classic signs of central nervous system infectious diseases. After years of taking care of patients with infectious diseases, several symptoms, signs, and cerebrospinal fluid abnormalities have been identified that are helpful time and time again in determining the etiological agent. These lessons, learned at the bedside, are reviewed in this article. KEYWORDS: Herpes simplex virus, Lyme disease, meningitis, viral encephalitis CLINICAL MANIFESTATIONS does not have an altered level of consciousness, sei- zures, or focal neurologic deficits. Although the ‘‘classic triad’’ of bacterial meningitis is The rash of a viral exanthema typically involves the fever, headache, and nuchal rigidity, vomiting is a face and chest first then spreads to the arms and legs. common early symptom. Suspect bacterial meningitis This can be an important clue in the patient with in the patient with fever, headache, lethargy, and headache, fever, and stiff neck that the meningitis is vomiting (without diarrhea). Patients may also com- due to echovirus or coxsackievirus. plain of photophobia. An altered level of conscious- Suspect tuberculous meningitis in the patient with ness that begins with lethargy and progresses to stupor either several weeks of headache, fever, and night during the emergency evaluation of the patient is sweats or a fulminant presentation with fever, altered characteristic of bacterial meningitis. mental status, and focal neurologic deficits. Fever (temperature 388C[100.48F]) is present in An Ixodes tick must be attached to the skin for at least 84% of adults with bacterial meningitis and in 80 to 24 hours to transmit infection with the spirochete 1–3 94% of children with bacterial meningitis. -
Health: Epidemiology Subchapter 41A
CHAPTER 41 – HEALTH: EPIDEMIOLOGY SUBCHAPTER 41A – COMMUNICABLE DISEASE CONTROL SECTION .0100 – REPORTING OF COMMUNICABLE DISEASES 10A NCAC 41A .0101 REPORTABLE DISEASES AND CONDITIONS (a) The following named diseases and conditions are declared to be dangerous to the public health and are hereby made reportable within the time period specified after the disease or condition is reasonably suspected to exist: (1) acquired immune deficiency syndrome (AIDS) - 24 hours; (2) anthrax - immediately; (3) botulism - immediately; (4) brucellosis - 7 days; (5) campylobacter infection - 24 hours; (6) chancroid - 24 hours; (7) chikungunya virus infection - 24 hours; (8) chlamydial infection (laboratory confirmed) - 7 days; (9) cholera - 24 hours; (10) Creutzfeldt-Jakob disease - 7 days; (11) cryptosporidiosis - 24 hours; (12) cyclosporiasis - 24 hours; (13) dengue - 7 days; (14) diphtheria - 24 hours; (15) Escherichia coli, shiga toxin-producing - 24 hours; (16) ehrlichiosis - 7 days; (17) encephalitis, arboviral - 7 days; (18) foodborne disease, including Clostridium perfringens, staphylococcal, Bacillus cereus, and other and unknown causes - 24 hours; (19) gonorrhea - 24 hours; (20) granuloma inguinale - 24 hours; (21) Haemophilus influenzae, invasive disease - 24 hours; (22) Hantavirus infection - 7 days; (23) Hemolytic-uremic syndrome – 24 hours; (24) Hemorrhagic fever virus infection - immediately; (25) hepatitis A - 24 hours; (26) hepatitis B - 24 hours; (27) hepatitis B carriage - 7 days; (28) hepatitis C, acute - 7 days; (29) human immunodeficiency -
One Vaccine, Two Diseases, Three Lessons
Wednesday, 2 October 2019 One vaccine, two diseases, three lessons Helen Petousis-Harris, PhD Senior Lecturer, Vaccinology Dept General Practice and Primary Health Care Overview Virtues of an outer Kissing cousins, two Serendipity and membrane vesicle vaccine? divergent diseases opportunity Wednesday, October 2, 2019 • Most meningococcal vaccines based on polysaccharide antigens (groups A, C, W135, Y) • Meningococcal Group B oligosaccharides cross react with fetal neuro tissue – not suitable vaccine antigen • Meningococcal Group B vaccine approaches needed to be 3 different – non PS-Conjugate Solution – outer membrane vesicles There are many other antigenic structures aside from PS Outer-membrane vesicles generate mainly strain specific responses against PorA which is highly variable across strains Developed in 1980’s and used Cuba and Norway 4 2/10/2019 Tan LKK, Carlone GM, Borrow R. Advances in the Development of Vaccines against Neisseria meningitidis. New England Journal of Medicine. 2010;362:1511-20. Meet the family 80-90% homology in primary sequences High level of recombination 5 Muzzi, A., Mora, M., Pizza, M., Rappuoli, R., & Donati, C. (2013). Conservation of meningococcal antigens in the genus Neisseria. MBio, 4(3), e00163-13. What is gonorrhoea? 6 2/10/2019 How common is gonorrhoea? • Second most reported sexually transmitted disease in US (600,000 cases per annum) • In NZ ~3000 cases per annum (60-90 per 100,000) • To put in context – Invasive Pneumococal Disease pre-vaccine <2s ~100 per 100,000 – Meningococcal disease at its height 17 per 100,000 • Tairawhiti DHB 400 per 100,000 7 No correlate of protection and repeat infections • Natural infection with gonorrhoea does not induce a protective immune response. -
2017 Indiana Report of Infectious Diseases
ANNUAL REPORT OF INFECTIOUS DISEASES 2017 INTRODUCTION Indiana Field Epidemiology Districts ................................................................................................ iv Indiana Population Estimates, 2017 ...........................................................................................v List of Reportable Diseases & Conditions in Indiana, 2017 ............................................................ vii FOODBORNE & WATERBORNE DISEASES & CONDITIONS ..................................................................... 1 Campylobacteriosis ............................................................................................................................ 3 Cryptosporidiosis ................................................................................................................................ 7 Escherichia coli, Shiga toxin-producing .......................................................................................... 11 Giardiasis ........................................................................................................................................... 15 Hepatitis A ........................................................................................................................................ 18 Legionellosis .................................................................................................................................... 21 Listeriosis ........................................................................................................................................ -
COMMUNICABLE DISEASES BULLETIN Centre for Disease Control
THE NORTHERN TERRITORY NT COMMUNICABLE DISEASES BULLETIN Centre for Disease Control ISSN 1323-8612 Vol. 5, No 1, March 1998 Congratulations to all the heroic service providers and volunteers who cleaned up after the Katherine and Douglas Daly River floods and kept things going throughout. In the aftermath of the Katherine and Douglas Daly River floods The recent floods in Katherine and the Douglas Ross River virus since the floods. In addition, there Daly River region gave CDC the opportunity to has been no apparent increase in the number of assess and review disease control priorities in cases of hepatitis A (incubation period 15-50 days, disaster situations. While disasters and their public usually 30 days) although it is still under enhanced health consequences differ according to individual Contents circumstances, a number of important lessons for In the aftermath of the Katherine and Douglas Daly River disaster preparedness can be learned from the floods .................................................................................. 1 international and local literature on disasters (short The effect of conjugate Hib vaccines on the incidence of invasive Hib disease in the NT ....................................... 3 list overleaf). The main dangers in the acute post- Evidence associating measles viruses with Crohn’s disaster phase are injuries and acute exacerbations disease and autism inconclusive ......................................... 6 of chronic diseases such as diabetes, especially if Update on HIV and hepatitis C in the NT........................... 7 medical supplies run short. Non-communicable diseases update: No.4 ......................... 9 Death of a five year old from meningococcal disease Outbreaks of infectious disease after a disaster are in Darwin.......................................................................... 12 Lessons from a case of meningococcal eye disease ......... -
Positive Rates of Anti-Acari-Borne Disease Antibodies of Rural Inhabitants in Japan
NOTE Public Health Positive rates of anti-acari-borne disease antibodies of rural inhabitants in Japan Tsutomu TAKEDA1)*, Hiromi FUJITA2), Masumi IWASAKI3), Moe KASAI3), Nanako TATORI4), Tomohiko ENDO5), Yuuji KODERA1,5) and Naoto YAMABATA6) 1)Wildlife Section, Center for Weed and Wildlife Management, Utsunomiya University, 350 Mine, Utsunomiya-shi, Tochigi 321-8505, Japan 2)Mahara Institute of Medical Acarology, 56-3 Aratano, Anan-shi, Tokushima 779-1510, Japan 3)Nikko Yumoto Visitor Center, National Parks Foundation Nikko Branch, Yumoto, Nikko-shi, Tochigi 321-1662, Japan 4)Department of Agriculture, Utsunomiya University, 350 Mine, Utsunomiya-shi, Tochigi 321-8505, Japan 5)United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan 6)Institute of Natural and Environmental Sciences, University of Hyogo, Sawano 940, Aogaki-cho, Tanba, Hyogo 669-3842, Japan J. Vet. Med. Sci. ABSTRACT. An assessment of acari (tick and mite) borne diseases was required to support 81(5): 758–763, 2019 development of risk management strategies in rural areas. To achieve this objective, blood samples were mainly collected from rural residents participating in hunting events. Out of 1,152 doi: 10.1292/jvms.18-0572 blood samples, 93 were positive against acari-borne pathogens from 12 prefectures in Japan. Urban areas had a lower rate of positive antibodies, whereas mountainous farming areas had a higher positive antibody prevalence. Residents of mountain areas were bitten by ticks or mites Received: 25 September 2018 significantly more often than urban residents. Resident of mountain areas, including hunters, may Accepted: 9 March 2019 necessary to be educated for prevention of akari-borne infectious diseases. -
Implementation Manual for the National Epidemiological Surveillance of Infectious Diseases Program
Implementation Manual for the National Epidemiological Surveillance of Infectious Diseases Program Part I. Purpose and Aim The National Epidemiological Surveillance of Infectious Diseases (NESID) Program was started in July 1981 with 18 target diseases. It has been operated with reinforcement and expansion along the way, including the adoption of a computerized online system and an increase in the target diseases to 27 diseases since January 1987. In response to the enactment of the Act on the Prevention of Infectious Disease and Medical Care for Patients with Infectious Diseases (Act No. 114 of 1998; hereinafter referred to as the “Act”) in September 1998 and its enforcement from April 1999, the NESID Program was positioned as a statutory measure. This program will build an appropriate system with cooperation from physicians and other healthcare workers, in order to prevent outbreaks and spread of various infectious diseases by ensuring that measures are taken for the effective and appropriate prevention, diagnosis and treatment of infectious diseases through the accurate monitoring and analysis of information on the occurrences of infectious diseases and through prompt provision and public disclosure of findings from such monitoring and analysis to the general public and healthcare workers, in order to design appropriate measures against infectious diseases by monitoring the detection status of, and identifying the characteristics of, circulating pathogens through collection and analysis of information on the pathogens. Part II. Target Infectious Diseases Target infectious diseases of this surveillance program shall be as follows. 1. Infectious diseases requiring report of all cases (notifiable diseases) Category I Infectious Diseases (1) Ebola hemorrhagic fever, (2) Crimean-Congo hemorrhagic fever, (3) smallpox, (4) South American hemorrhagic fever, (5) plague, (6) Marburg disease, (7) Lassa fever. -
| Oa Tai Ei Rama Telut Literatur
|OA TAI EI US009750245B2RAMA TELUT LITERATUR (12 ) United States Patent ( 10 ) Patent No. : US 9 ,750 ,245 B2 Lemire et al. ( 45 ) Date of Patent : Sep . 5 , 2017 ( 54 ) TOPICAL USE OF AN ANTIMICROBIAL 2003 /0225003 A1 * 12 / 2003 Ninkov . .. .. 514 / 23 FORMULATION 2009 /0258098 A 10 /2009 Rolling et al. 2009 /0269394 Al 10 /2009 Baker, Jr . et al . 2010 / 0034907 A1 * 2 / 2010 Daigle et al. 424 / 736 (71 ) Applicant : Laboratoire M2, Sherbrooke (CA ) 2010 /0137451 A1 * 6 / 2010 DeMarco et al. .. .. .. 514 / 705 2010 /0272818 Al 10 /2010 Franklin et al . (72 ) Inventors : Gaetan Lemire , Sherbrooke (CA ) ; 2011 / 0206790 AL 8 / 2011 Weiss Ulysse Desranleau Dandurand , 2011 /0223114 AL 9 / 2011 Chakrabortty et al . Sherbrooke (CA ) ; Sylvain Quessy , 2013 /0034618 A1 * 2 / 2013 Swenholt . .. .. 424 /665 Ste - Anne -de - Sorel (CA ) ; Ann Letellier , Massueville (CA ) FOREIGN PATENT DOCUMENTS ( 73 ) Assignee : LABORATOIRE M2, Sherbrooke, AU 2009235913 10 /2009 CA 2567333 12 / 2005 Quebec (CA ) EP 1178736 * 2 / 2004 A23K 1 / 16 WO WO0069277 11 /2000 ( * ) Notice : Subject to any disclaimer, the term of this WO WO 2009132343 10 / 2009 patent is extended or adjusted under 35 WO WO 2010010320 1 / 2010 U . S . C . 154 ( b ) by 37 days . (21 ) Appl. No. : 13 /790 ,911 OTHER PUBLICATIONS Definition of “ Subject ,” Oxford Dictionary - American English , (22 ) Filed : Mar. 8 , 2013 Accessed Dec . 6 , 2013 , pp . 1 - 2 . * Inouye et al , “ Combined Effect of Heat , Essential Oils and Salt on (65 ) Prior Publication Data the Fungicidal Activity against Trichophyton mentagrophytes in US 2014 /0256826 A1 Sep . 11, 2014 Foot Bath ,” Jpn . -
Illinois Register Department of Public Health Notice of Proposed Amendments Title 77
ILLINOIS REGISTER DEPARTMENT OF PUBLIC HEALTH NOTICE OF PROPOSED AMENDMENTS TITLE 77: PUBLIC HEALTH CHAPTER I: DEPARTMENT OF PUBLIC HEALTH SUBCHAPTER k: COMMUNICABLE DISEASE CONTROL AND IMMUNIZATIONS PART 690 CONTROL OF COMMUNICABLE DISEASES CODE SUBPART A: GENERAL PROVISIONS Section 690.10 Definitions 690.20 Incorporated and Referenced Materials 690.30 General Procedures for the Control of Communicable Diseases SUBPART B: REPORTABLE DISEASES AND CONDITIONS Section 690.100 Diseases and Conditions 690.110 Diseases Repealed from This Part SUBPART C: REPORTING Section 690.200 Reporting SUBPART D: DETAILED PROCEDURES FOR THE CONTROL OF COMMUNICABLE DISEASES Section 690.290 Acquired Immunodeficiency Syndrome (AIDS) (Repealed) 690.295 Any Unusual Case of a Disease or Condition Caused by an Infectious Agent Not Listed in this Part that is of Urgent Public Health Significance (Reportable by telephone immediately (within three hours)) 690.300 Amebiasis (Reportable by mail, telephone, facsimile or electronically as soon as possible, within 7 days) (Repealed) 690.310 Animal Bites (Reportable by mail or telephone as soon as possible, within 7 days) (Repealed) 690.320 Anthrax (Reportable by telephone immediately, within three hours, upon initial clinical suspicion of the disease) 690.322 Arboviral Infections (Including, but Not Limited to, Chikungunya Fever, ILLINOIS REGISTER DEPARTMENT OF PUBLIC HEALTH NOTICE OF PROPOSED AMENDMENTS California Encephalitis, St. Louis Encephalitis, Dengue Fever and West Nile Virus) (Reportable by mail, telephone, facsimile