Neisseria Infection of Rhesus Macaques As a Model to Study Colonization, Transmission, Persistence, and Horizontal Gene Transfer
Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer Nathan J. Weyanda,b,1, Anne M. Wertheimerc,d,e, Theodore R. Hobbsf,g, Jennifer L. Siskoa,b, Nyiawung A. Takua,b, Lindsay D. Gregstona,b, Susan Claryh, Dustin L. Higashia,b, Nicolas Biaisi,2, Lewis M. Browni,j, Shannon L. Planerg,k, Alfred W. Legasseg,k, Michael K. Axthelmg,k,l, Scott W. Wongg,h,l, and Magdalene Soa,b aBIO5 Institute and bDepartment of Immunobiology, University of Arizona, Tucson, AZ 85721; cArizona Center on Aging, dDepartment of Medicine and eDivision of Geriatrics General Internal and Palliative Medicine, University of Arizona, Tucson, AZ, 85719; fDivision of Animal Resources, kDivision of Pathobiology and Immunology, gOregon National Primate Research Center, and lVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006; hDepartment of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, Portland, OR 97239; and iDepartment of Biological Sciences and jQuantitative Proteomics Center, Columbia University, New York, NY 10027 Edited by Rino Rappuoli, Novartis Vaccines and Diagnostics, Siena, Italy, and approved January 10, 2013 (received for review October 9, 2012) The strict tropism of many pathogens for man hampers the de- may be possible to develop a model for studying Neisseria–host velopment of animal models that recapitulate important microbe– interactions in which there are no host-restriction barriers to host interactions. We developed a rhesus macaque model for study- overcome. ing Neisseria–host interactions using Neisseria species indigenous to The rhesus macaque (RM) has ∼93% DNA sequence identity the animal.
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