Tropical Geometry of Biological Systems O Radulescu To cite this version: O Radulescu. Tropical Geometry of Biological Systems. CASC 2020, Sep 2020, Linz, Austria. hal- 02949563 HAL Id: hal-02949563 https://hal.archives-ouvertes.fr/hal-02949563 Submitted on 25 Sep 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Tropical Geometry of Biological Systems (Invited Talk) O. Radulescu University of Montpellier, and CNRS UMR5235 LPHI, Montpellier, France
[email protected] Abstract. Tropical geometry ideas were developed by mathematicians that got inspired from very different topics in physics, discrete mathe- matics, optimization, algebraic geometry. In tropical geometry, tools like the logarithmic transformation coarse grain complex objects, drastically simplifying their analysis. I discuss here how similar concepts can be applied to dynamical systems used in biological modeling. In particular, tropical geometry is a natural framework for model reduction and for the study of metastability and itinerancy phenomena in complex biochemical networks. Keywords: Tropical geometry, chemical reaction networks, model reduction, singular perturbations, metastability, itinerancy 1 Introduction Mathematical modelling of biological systems is a daunting challenge. In or- der to cope realistically with the biochemistry of cells, tissues and organisms, both in fundamental and applied biological research, systems biology models use hundreds and thousands of variables structured as biochemical networks [16,38,1].