Email [email protected] Description Q2FV59 Tue Jul 17 17:05:54 BST Date 2012 Unique Job 2b2080859139b16d ID

Detailed template

information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

PDB header: Chain: A: PDB Molecule:dehydrosqualene synthase; 1 c2zcpA_ Alignment 100.0 99 PDBTitle: crystal structure of the c(30) dehydrosqualene2 synthase from staphylococcus aureus complexed with3 farnesyl thiopyrophosphate

Fold: synthases 2 d1ezfa_ Alignment 100.0 18 Superfamily:Terpenoid synthases Family: synthase

PDB header:transferase Chain: G: PDB Molecule:geranyl diphosphate synthase; 3 c3aq0G_ Alignment 98.4 15 PDBTitle: ligand-bound form of arabidopsis medium/long-chain length prenyl2 synthase (surface polar residue mutant)

Fold:Terpenoid synthases 4 d2q80a1 Alignment 98.0 12 Superfamily:Terpenoid synthases Family:Isoprenyl diphosphate synthases

PDB header:transferase Chain: A: PDB Molecule:polyprenyl synthetase; 5 c4dhdA_ 97.9 13 Alignment PDBTitle: crystal structure of isoprenoid synthase a3msh1 (target efi-501992)2 from pyrobaculum calidifontis

PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate 6 c1wy0A_ Alignment 97.9 13 synthetase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthetase from2 pyrococcus horikoshii ot3

Fold:Terpenoid synthases 7 d1v4ea_ Alignment 97.8 15 Superfamily:Terpenoid synthases Family:Isoprenyl diphosphate synthases

PDB header:transferase Chain: D: PDB Molecule:farnesyl-diphosphate synthase; 8 c3m9uD_ 97.7 10 Alignment PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase2 from lactobacillus brevis atcc 367

PDB header:transferase Chain: B: PDB Molecule:decaprenyl diphosphate synthase; 9 c3mzvB_ 97.7 11 Alignment PDBTitle: crystal structure of a decaprenyl diphosphate synthase from2 rhodobacter capsulatus

PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate synthase; 10 c3n3dB_ 97.6 13 Alignment PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase from2 lactobacillus brevis atcc 367

PDB header:transferase Chain: B: PDB Molecule:trans-isoprenyl diphosphate synthase; 11 c3oyrB_ Alignment 97.4 11 PDBTitle: crystal structure of polyprenyl synthase from caulobacter crescentus2 cb15 complexed with calcium and isoprenyl diphosphate PDB header:transferase Chain: A: PDB Molecule:putative polyprenyl synthetase; 12 c3nf2A_ 97.3 14 Alignment PDBTitle: crystal structure of polyprenyl synthetase from streptomyces2 coelicolor a3(2)

PDB header:transferase Chain: B: PDB Molecule:octaprenyl-diphosphate synthase; 13 c3rmgB_ 97.2 10 Alignment PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase from2 bacteroides thetaiotaomicron

PDB header:transferase Chain: D: PDB Molecule:component b of hexaprenyl diphosphate 14 c3aqbD_ Alignment 97.1 15 synthase; PDBTitle: m. luteus b-p 26 heterodimeric hexaprenyl diphosphate synthase in2 complex with magnesium

PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate 15 c2e8xB_ Alignment 97.0 16 synthetase; PDBTitle: s. cerevisiae geranylgeranyl pyrophosphate synthase in2 complex with magnesium and gpp

PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthase; 16 c3lmdA_ 96.6 8 Alignment PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase2 from corynebacterium glutamicum atcc 13032

PDB header:transferase Chain: A: PDB Molecule:octaprenyl pyrophosphate synthase; 17 c3tc1A_ 96.6 15 Alignment PDBTitle: crystal structure of octaprenyl pyrophosphate synthase from2 helicobacter pylori

Fold:Terpenoid synthases 18 d1rtra_ Alignment 96.4 11 Superfamily:Terpenoid synthases Family:Isoprenyl diphosphate synthases

PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 19 c3ts7B_ 96.2 12 Alignment PDBTitle: crystal structure of farnesyl diphosphate synthase (target efi-501951)2 from methylococcus capsulatus

PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthase; 20 c3lk5A_ 95.7 12 Alignment PDBTitle: crystal structure of putative geranylgeranyl pyrophosphate synthase2 from corynebacterium glutamicum

PDB header:transferase Chain: A: PDB Molecule:trans-isoprenyl diphosphate synthase; 21 c3oyrA_ Alignment not modelled 95.4 10 PDBTitle: crystal structure of polyprenyl synthase from caulobacter crescentus2 cb15 complexed with calcium and isoprenyl diphosphate PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 22 c3ucaB_ not modelled 95.3 15 Alignment PDBTitle: crystal structure of isoprenoid synthase (target efi- 501974) from2 clostridium perfringens PDB header:transferase Chain: B: PDB Molecule:farnesyl diphosphate synthase; 23 c3m0gB_ not modelled 94.8 18 Alignment PDBTitle: crystal structure of putative farnesyl diphosphate synthase from2 rhodobacter capsulatus PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 24 c3ipiA_ not modelled 94.5 11 Alignment PDBTitle: crystal structure of a geranyltranstransferase from the2 methanosarcina mazei PDB header:transferase Chain: A: PDB Molecule: synthetase; 25 c3cp6A_ not modelled 94.4 15 Alignment PDBTitle: crystal structure of human farnesyl diphosphate synthase (t201a2 mutant) complexed with mg and biphosphonate inhibitor PDB header: Chain: A: PDB Molecule:isoprene synthase; 26 c3n0fA_ not modelled 94.4 14 Alignment PDBTitle: crystal structure of isoprene synthase from grey poplar leaves2 (populus x canescens) PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate 27 c2azjB_ Alignment not modelled 94.4 12 synthetase; PDBTitle: crystal structure for the mutant d81c of sulfolobus2 solfataricus hexaprenyl pyrophosphate synthase PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl diphosphate synthetase; 28 c1wmwA_ Alignment not modelled 94.3 17 28 c1wmwA_ not modelled 94.3 17 Alignment PDBTitle: crystal structure of geranulgeranyl diphosphate synthase from thermus2 thermophilus PDB header:lyase Chain: A: PDB Molecule:epi-isozizaene synthase; 29 c3lg5A_ not modelled 93.9 11 Alignment PDBTitle: f198a epi-isozizaene synthase: complex with mg, inorganic2 pyrophosphate and benzyl triethyl ammonium cation Fold:Terpenoid synthases 30 d1fpsa_ Alignment not modelled 93.2 13 Superfamily:Terpenoid synthases Family:Isoprenyl diphosphate synthases PDB header:transferase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase; 31 c1yhlA_ not modelled 93.0 17 Alignment PDBTitle: structure of the complex of trypanosoma cruzi farnesyl diphosphate2 synthase with risedronate, dmapp and mg+2 PDB header:lyase 32 c1hx9A_ Alignment not modelled 93.0 15 Chain: A: PDB Molecule:5-epi-aristolochene synthase; PDBTitle: crystal structure of teas w273s form 1

Fold:Terpenoid synthases 33 d5easa2 Alignment not modelled 92.2 15 Superfamily:Terpenoid synthases Family:Terpenoid cyclase C-terminal domain PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl pyrophosphate 34 c2j1pB_ Alignment not modelled 92.1 16 synthetase; PDBTitle: geranylgeranyl diphosphate synthase from sinapis alba in2 complex with ggpp Fold:Terpenoid synthases 35 d1rqja_ Alignment not modelled 91.5 13 Superfamily:Terpenoid synthases Family:Isoprenyl diphosphate synthases PDB header:lyase Chain: B: PDB Molecule:(+)-delta-cadinene synthase isozyme xc1; 36 c3g4dB_ not modelled 91.3 17 Alignment PDBTitle: crystal structure of (+)-delta-cadinene synthase from gossypium2 arboreum and evolutionary divergence of metal binding motifs for3 PDB header: Chain: A: PDB Molecule:(+)-bornyl diphosphate synthase; 37 c1n20A_ not modelled 90.5 15 Alignment PDBTitle: (+)-bornyl diphosphate synthase: complex with mg and 3-aza-2 2,3-dihydrogeranyl diphosphate Fold:Terpenoid synthases 38 d1n1ba2 Alignment not modelled 90.3 14 Superfamily:Terpenoid synthases Family:Terpenoid cyclase C-terminal domain PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative farnesyl pyrophosphate 39 c2o1oB_ Alignment not modelled 90.1 14 synthase; PDBTitle: cryptosporidium parvum putative polyprenyl pyrophosphate2 synthase (cgd4_2550) in complex with risedronate. PDB header:lyase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase, putative; 40 c3ez3A_ not modelled 89.9 13 Alignment PDBTitle: crystal structure of plasmodium vivax geranylgeranylpyrophosphate2 synthase pvx_092040 with zoledronate and ipp bound PDB header:transferase Chain: F: PDB Molecule:farnesyl diphosphate synthase; 41 c2f94F_ not modelled 88.7 15 Alignment PDBTitle: crystal structure of human fpps in complex with ibandronate PDB header:transferase Chain: B: PDB Molecule:geranyl diphosphate synthase small 42 c3qkcB_ Alignment not modelled 87.8 13 subunit; PDBTitle: crystal structure of geranyl diphosphate synthase small subunit from2 antirrhinum majus Fold:Terpenoid synthases 43 d1ps1a_ Alignment not modelled 86.9 7 Superfamily:Terpenoid synthases Family:Aristolochene/pentalenene synthase PDB header:lyase Chain: B: PDB Molecule:1,8-cineole synthase; 44 c2j5cB_ Alignment not modelled 85.0 14 PDBTitle: rational conversion of and specificity2 in a monoterpene synthase. structural insights into the3 molecular basis of rapid evolution. PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 45 c3p8rA_ not modelled 84.7 14 Alignment PDBTitle: crystal structure of polyprenyl synthase from vibrio cholerae PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 46 c3p8lB_ not modelled 84.5 13 Alignment PDBTitle: crystal structure of polyprenyl synthase from enterococcus faecalis2 v583 PDB header:lyase Chain: A: PDB Molecule:alpha-bisabolene synthase; 47 c3saeA_ not modelled 84.3 12 Alignment PDBTitle: structure of a three-domain sesquiterpene synthase: a prospective2 target for advanced biofuels production PDB header:transferase Chain: A: PDB Molecule:polyprenyl synthetase; 48 c4fp4A_ not modelled 84.0 11 Alignment PDBTitle: crystal structure of isoprenoid synthase a3mx09 (target efi-501993)2 from pyrobaculum calidifontis PDB header:lyase Chain: A: PDB Molecule:4s-limonene synthase; 49 c2ongA_ not modelled 82.2 17 Alignment PDBTitle: crystal structure of of limonene synthase with 2-2 fluorogeranyl diphosphate (fgpp). PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 50 c3lomA_ not modelled 81.3 12 Alignment PDBTitle: crystal structure of geranyltransferase from legionella2 pneumophila Fold:Terpenoid synthases 51 d1kiya_ Alignment not modelled 81.3 12 Superfamily:Terpenoid synthases Family:Trichodiene synthase PDB header:lyase Chain: B: PDB Molecule:taxadiene synthase; 52 c3p5rB_ Alignment not modelled 79.6 15 PDBTitle: crystal structure of taxadiene synthase from pacific yew Alignment (taxus2 brevifolia) in complex with mg2+ and 2- fluorogeranylgeranyl3 diphosphate PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthase; 53 c2ogdB_ not modelled 78.2 17 Alignment PDBTitle: t. brucei farnesyl diphosphate synthase complexed with bisphosphonate2 bph-527 PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 54 c3lsnA_ not modelled 74.9 13 Alignment PDBTitle: crystal structure of putative geranyltranstransferase from pseudomonas2 fluorescens pf-5 complexed with magnesium PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase (ispa); 55 c3llwA_ not modelled 71.9 9 Alignment PDBTitle: crystal structure of geranyltransferase from helicobacter2 pylori 26695 PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 56 c2forB_ Alignment not modelled 69.0 14 PDBTitle: crystal structure of the shigella flexneri farnesyl pyrophosphate2 synthase complex with an isopentenyl pyrophosphate PDB header:lyase, isomerase 57 c3s9vD_ Alignment not modelled 66.2 11 Chain: D: PDB Molecule:abietadiene synthase, chloroplastic; PDBTitle: abietadiene synthase from abies grandis PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 58 c2ftzA_ not modelled 63.7 23 Alignment PDBTitle: crystal structure of geranyltranstransferase (ec 2.5.1.10) (tm0161)2 from thermotoga maritima at 1.90 a resolution PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 59 c4f62B_ not modelled 50.3 14 Alignment PDBTitle: crystal structure of a putative farnesyl-diphosphate synthase from2 marinomonas sp. med121 (target efi-501980) Fold:Terpenoid synthases 60 d1di1a_ Alignment not modelled 48.5 9 Superfamily:Terpenoid synthases Family:Aristolochene/pentalenene synthase PDB header:lyase Chain: A: PDB Molecule:2-methylisoborneol synthase; 61 c3v1vA_ Alignment not modelled 45.2 12 PDBTitle: crystal structure of 2-methylisoborneol synthase from streptomyces2 coelicolor a3(2) in complex with mg2+ and geranyl- s-thiolodiphosphate PDB header:transcription Chain: B: PDB Molecule:tena homolog; 62 c3oqlB_ not modelled 42.2 8 Alignment PDBTitle: crystal structure of a tena homolog (pspto1738) from pseudomonas2 syringae pv. tomato str. dc3000 at 2.54 a resolution PDB header:lyase Chain: A: PDB Molecule:2-methylisoborneol synthase; 63 c3v1xA_ Alignment not modelled 41.4 9 PDBTitle: crystal structure of 2-methylisoborneol synthase from streptomyces2 coelicolor a3(2) in complex with mg2+ and 2- fluorogeranyl diphosphate PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; 64 c2h8oA_ not modelled 41.4 12 Alignment PDBTitle: the 1.6a crystal structure of the geranyltransferase from2 agrobacterium tumefaciens PDB header:transferase Chain: B: PDB Molecule:geranyl diphosphate synthase small 65 c3kraB_ Alignment not modelled 41.3 9 subunit; PDBTitle: mint heterotetrameric synthase in2 complex with magnesium PDB header:transcription Chain: A: PDB Molecule:tena homolog; 66 c3oqlA_ not modelled 34.8 8 Alignment PDBTitle: crystal structure of a tena homolog (pspto1738) from pseudomonas2 syringae pv. tomato str. dc3000 at 2.54 a resolution PDB header:biosynthetic protein Chain: F: PDB Molecule:protein mraz; PDBTitle: crystal structure of a cell division and cell wall2 67 c1n0fF_ not modelled 33.8 11 Alignment biosynthesis protein upf0040 from mycoplasma pneumoniae:3 indication of a novel fold with a possible new conserved4 sequence motif PDB header: Chain: A: PDB Molecule:transcriptional regulator; 68 c2rd3A_ not modelled 29.5 14 Alignment PDBTitle: crystal structure of tena homologue (hp1287) from2 helicobacter pylori Fold:Double-split beta-barrel 69 d1n0ea_ Alignment not modelled 26.9 11 Superfamily:AbrB/MazE/MraZ-like Family:Hypothetical protein MraZ

PDB header:lyase 70 c1hm4A_ Alignment not modelled 24.2 7 Chain: A: PDB Molecule:pentalenene synthase; PDBTitle: n219l pentalenene synthase

Fold:Heme oxygenase-like 71 d1udda_ Alignment not modelled 22.1 16 Superfamily:Heme oxygenase-like Family:TENA/THI-4 PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, abrb family; 72 c2l66B_ not modelled 18.6 4 Alignment PDBTitle: the dna-recognition fold of sso7c4 suggests a new member of spovt-abrb2 superfamily from archaea. PDB header:lyase Chain: B: PDB Molecule:transcriptional activator tena-1; 73 c2qzcB_ not modelled 18.2 11 Alignment PDBTitle: crystal structure of a putative tena-like (tena- 1, sso2206)2 from sulfolobus solfataricus p2 at 1.50 a resolution PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate 74 c2j1oA_ not modelled 17.8 12 Alignment synthetase; PDBTitle: geranylgeranyl diphosphate synthase from sinapis alba PDB header:lipid binding protein Chain: A: PDB Molecule:acyl-coa-binding domain-containing 75 c3epyA_ Alignment not modelled 17.6 10 protein 7; PDBTitle: crystal structure of human acyl-coa binding domain 72 complexed with palmitoyl-coa PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; 76 c3npkB_ not modelled 15.3 15 Alignment PDBTitle: the crystal structure of geranyltranstransferase from campylobacter2 jejuni PDB header:unknown function Chain: B: PDB Molecule:tena/thi-4 protein, domain of unknown function with a heme 77 c3ddeB_ not modelled 13.8 14 Alignment PDBTitle: crystal structure of a domain of unknown function with a heme2 oxygenase-like fold (sden_3740) from shewanella denitrificans os2173 at 2.30 a resolution Fold:Heme oxygenase-like 78 d1otva_ Alignment not modelled 13.5 11 Superfamily:Heme oxygenase-like Family:PqqC-like

Fold:Double-split beta-barrel 79 d1yfba1 Alignment not modelled 13.1 5 Superfamily:AbrB/MazE/MraZ-like Family:AbrB N-terminal domain-like

Fold:Heme oxygenase-like 80 d1rcwa_ Alignment not modelled 12.7 12 Superfamily:Heme oxygenase-like Family:PqqC-like Fold:DNA/RNA-binding 3-helical bundle Superfamily:TrpR-like 81 d1j1va_ not modelled 12.2 13 Alignment Family:Chromosomal replication initiation factor DnaA C-terminal domain IV PDB header:isomerase Chain: A: PDB Molecule:peroxisomal d3,d2-enoyl-coa isomerase; 82 c2cquA_ not modelled 11.5 14 Alignment PDBTitle: solution structure of rsgi ruh-045, a human acyl-coa2 binding protein Fold:Double-split beta-barrel 83 d2fy9a1 Alignment not modelled 11.3 14 Superfamily:AbrB/MazE/MraZ-like Family:AbrB N-terminal domain-like PDB header:virus Chain: A: PDB Molecule:capsid protein; 84 c2vf1A_ not modelled 11.2 30 Alignment PDBTitle: x-ray crystallographic structure of the picobirnavirus2 capsid PDB header:isomerase Chain: B: PDB Molecule:ent-copalyl diphosphate synthase, chloroplastic; 85 c3pybB_ not modelled 9.0 9 Alignment PDBTitle: crystal structure of ent-copalyl diphosphate synthase from arabidopsis2 thaliana in complex with 13-aza-13,14- dihydrocopalyl diphosphate PDB header:transcription Chain: B: PDB Molecule:stage v sporulation protein t; 86 c2ro5B_ Alignment not modelled 8.8 14 PDBTitle: rdc-refined solution structure of the n-terminal dna recognition2 domain of the bacillus subtilis transition-state regulator spovt PDB header:hydrolase Chain: C: PDB Molecule:translin associated factor x, isoform b; 87 c3riuC_ not modelled 8.1 18 Alignment PDBTitle: crystal structure of drosophila hexameric c3po formed by truncated2 translin and trax Fold:Acyl-CoA binding protein-like 88 d1hbka_ Alignment not modelled 8.0 10 Superfamily:Acyl-CoA binding :Acyl-CoA binding protein PDB header:oxygen storage/transport Chain: A: PDB Molecule:hemoglobin component vii; 89 c1x46A_ not modelled 7.9 8 Alignment PDBTitle: crystal structure of a hemoglobin component (ta-vii) from2 tokunagayusurika akamusi PDB header:transcription 90 c2bj3D_ Alignment not modelled 7.9 18 Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo PDB header:protein turnover Chain: A: PDB Molecule:ubiquitin fusion degradation protein 1; 91 c1zc1A_ not modelled 7.4 12 Alignment PDBTitle: ufd1 exhibits the aaa-atpase fold with two distinct2 ubiquitin interaction sites PDB header:transcription 92 c2w1tB_ Alignment not modelled 7.2 14 Chain: B: PDB Molecule:stage v sporulation protein t; PDBTitle: crystal structure of b. subtilis spovt PDB header:cell cycle Chain: Y: PDB Molecule:borealin; 93 c2raxY_ not modelled 7.0 13 Alignment PDBTitle: crystal structure of borealin (20-78) bound to survivin (1- 120) Fold:Glycosyl hydrolase domain 94 d2aaaa1 Alignment not modelled 6.8 7 Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain

Fold:Ribbon-helix-helix 95 d2bj7a1 Alignment not modelled 6.8 16 Superfamily:Ribbon-helix-helix Family:CopG-like

Fold:Thioredoxin fold 96 d1un2a_ Alignment not modelled 6.6 8 Superfamily:Thioredoxin-like Family:DsbA-like

Fold:Ribbon-helix-helix 97 d2hzaa1 Alignment not modelled 6.4 14 Superfamily:Ribbon-helix-helix Family:CopG-like PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase; 98 c2qneA_ Alignment not modelled 6.4 15 PDBTitle: crystal structure of putative methyltransferase (zp_00558420.1) from2 desulfitobacterium hafniense y51 at 2.30 a resolution Fold:Methionine synthase domain-like 99 d3bula1 Alignment not modelled 6.3 15 Superfamily:Methionine synthase domain Family:Methionine synthase domain