September 29, l ')')2 Vol. XLIV No. 20 "Still U.S. Department of Health The Second and Human Services Best Thing About Payday" National Institutes of Health

'At the Crossroads... ' Conte Building Dedicated NIH Hosts Groundbreaking Amid Fond Remembrances Ceremony for Natcher Bldg. By Rich McManus By Carla Garnett e was a hearty, funloving, passionate, bout 5 weeks ago, Rep. William H. Hstubborn man, but this last quality A Natcher (D-Ky.) was taking a walk proved most important for Rep. Silvio 0. through his home district when he met an Conte, the late Massachusetts legislator in elderly man he had known for several years. As whose memory the recently completed Bldg. 49 Natcher spoke, one could imagine the man bent was dedicated on Sept. 17. at the waist, shuffling along with the aid of a For the better part of two decades, Conte cane and obviously in very poor health. struggled in Congress to obtain funds for However, Natcher said, the old man was lucid increased pediatric research at NIH. His enough not only to recognize and greet his Rep. William H. Natcher ofKentucky shares a tenacity was rewarded in 1988 when ground congressman, but also to offer him some sage light moment with NIH director Dr. Bernadine was broken for the Child Health and Neuro­ advice. Healy during the groundbreaking ceremony held sciences Building, now known as the Silvio 0. 'Tm 70 years old now," the constituent said, Sept. I I-his 83rd birthday-forthe NIH Conte Bldg. adopting a paternal tone, "and look at me. I'm campus building that will bear his name. 'This didn't come easy," said Rep. Joe Early not well. When you get to be my age I want (D-Mass.), a longtime friend of Conte's who you to take better care of yourself than I have." spoke at the dedication. "Twelve years ago, a The octagenarian congressman nodded, bill for this building was knocked out of the accepting this wisdom with an inner smile and House by a member from Missouri, whom I engraving the encounter in his long-term won't name. memory. "I promised him I would," he said. "But Corinne," he said, addressing Conte's A fit and grinning Natcher relished retelling wife, "how proud Silvio would be today. He this story at NIH on Sept. 11, the day he told me this was his biggest thrill, the finest turned 83 and the day ground was broken for thing that ever happened to him." the campus building that will bear his name and Early, as devoid of pretense as the man he legacy. came to honor, reenacted for the crowd of NIH "I have always believed that if you take care of officials what he imagined Conte's reaction the health of your people and educate your would be were he still alive: (See NATCHER, Page 10) (See CONTE, Page 4) Nursing Research in Action Researchers Bank on NIGMS Cell Repository, Now Age 20 NCNR's Intramural Program Moves Ahead in Third Year By Ann Dieffenbach I t may be a bank, but it receives interest By June Wyman from its customers-scientific interest, that Corinne Conte, widow of Rep. Silvio Conte (R­ 0 ne day each month, Ron Wilson (an is. The NIGMS Human Genetic Mutant Cell Mass.), unveils the plaque that adorns the new alias) flies from his home in Orlando to the NIH Clinical Center and pumps iron before Repository, which is 20 years old in 1992, is an research facility at NIH named after her husband, an audience. As the audience watches intently important resource for scientists working to a longtime champion in Congress ofbiomedical and records his time, Wilson gets up from a understand basic genetic and cellular processes, research. Looking on is NIHdirector Dr. prone position, walks 30 feet, lifts weights, and as well as diseases in which these processes go Bernadine Healy, who remembered Rep. Conte as climbs stairs. awry. a vigorous defender of the American famil,y, Wilson is being studied by nurse researchers The repository provides researchers with well­ particularly children. characterized, uncontaminated cell lines on the intramural staff of the National Center representing genetic diseases and disorders with for Nursing Research. The main purpose of his a genetic component. The collection also CFC Kickoff Set for Oct. 14 trips is to receive AZT treatment for HIV contains cells from apparently normal individu­ The annual Combined Federal Campaign infection as part of an NIAID clinical trial. But als, which can serve as experimental controls. kickoffwill be held on Wednesday, Oct. 14 at he also participates in an NCNR study of how Using cells from the NIGMS repository, 11:45 a.m. in front of Bldg. 1. Fun, food and muscle weakness affects the lives of HIV­ scientists have made major findings about the entertainment will be offered to all who infected patients. genes involved in a variety of diseases including attend. The NIH Health's Angels will Now in its third year, NCNR's intramural Huntington's disease, cystic fibrosis, Duchenne sponsor its annual RunlWalk, t-shirts and program is pioneering a kind of research that muscular dystrophy, retinitis pigmentosa, race registrations forwhich are available at focuses more on patients' problems and familial hypercholesterolemia, and R&W stores. A free rafflewill include such experiences than on their disease or its treat­ neurofibromatosis. prizes as a 20-inch color 1V, courtesy of ment. "We'll often study something that's a problem Filling a Need GEICO, two round-trip airfares on USAir, Cineplex Odeon movie tickets, and a pair of for the patient, like fatigue or night sweats," The idea for a cell repository grew out of Washington Capitals hockey tickets. See you explained Dr. Mary E. Ropka, director of the changes in scientific research that took place there! program. "The goal is to make patients' lives (See CELL BANK, Page 6) (See NURSING RESEARCH, Page 8) The Record page 2 September 29, I 992

NCl's PDQ Has New Editor

The NCI recently announced that Dr. Daniel G. Haller, program leader for clinical oncology research at the University of Pennsylvania Cancer Center, Philadelphia, is the new editor­ in-chief of the PDQ editorial board. A member of the board for more than 3 years, he believes that "PDQ represents an unparalleled opportu­ nity to access timely and important cancer information." He succeeds Dr. Robert C. Young, president of Fox Chase Cancer Center in Philadelphia, who had served 8 years on the editorial board, 5 of them as editor-in-chief. PDQ is a database that contains information Newly appointed PDQ editor-in-chiefDr. Daniel Haller (far l) meets with former editors-in-chief Drs. about state-of-the-art cancer treatment, ongoing Robert Young and Daniel Ihde and !CIC Director Susan Hubbard at a recent board meeting. clinical trials, as well as closed clinical trials, and a directory of oncologic specialists and organiza­ tions providing cancer care in the United States. 80 formsof cancer and can be accessed in a available through the CancerFax computer, The editorial board meets monthly to review variety of ways by physicians and patients, as 402-5874. Information from the database can and update the database. The board was well as nurses, social workers, and medical also be accessed through CancerNet, ICIC's established in 1984 with Dr. Daniel Ihde, now writers. PDQ is maintained by staff at the newest service, using the electronic mail services deputy director of NCI, as the first editor-in­ International Cancer Information Center of Internet or BITNET. Internet users may chief of PDQ. At present, the core board (ICIC), headquartered in NCI's Bloch Bldg., send a message to- consists of 21 cancer specialists in adult cancers; located at the edge of the campus on Old cancernet@icicb. nci. nih. gov-with a blank it is supplemented by pediatric, early detection/ Georgetown Rd. subject line and the word HELP in the body of prevention, and supportive care boards. A Widely accessible, PDQ is available through a the mail message. Within 10 minutes, board to develop a file of investigational drugs personal computer with a modem and through CancerNet will send a return mail message is expected to convene later this year. CD-ROM. For those who do not have access containing instructions for accessing PDQ NINOSPDQ contains Honors information Summer on approximatelyStudents to a computer, PDQ information is also information. For general information about PDQ or how to use it, call the Cancer Information Service, 1- The National Institute of Neurological 800-4-CANCER, CancerFax at 301-402-5874, Disorders and Stroke honored 39 of the or ICIC at 496-7403. 0 students working in the NINDS Summer Program in the Neurological Sciences at the recent 8th annual Summer Student Awards TheNIH Record Ceremony. Published biweekly at Bethesda, Md., by the Editorial The program provides an opportunity for Operations Branch, Division of Public Information, for students to participate in research involving all the information of employees of the National Institutes of aspects of the brain and nervous system. Each Health, Department of Health and Human Services, and year, the institute acknowledges students who circulated to nonemployees by subscription only through have done exceptional work in this program. the Government Printing Office. The content is reprintable without permission. Pictures may be available on request. The students received letters of commendation Use of funds forprinting this periodical has been approved or award packages that included a certificate, by the director of the Office of Management and Budget textbook and paperweight. through September 30, 1992. Recipients of the Exceptional Summer NIH Record Office Correspondents: Student Award included: Jack Chen, Scott Bldg. 31, Room 2B-03 CC, Sue Kendall Henson, Omar Khan, Elaine Lau, Eunice Lau, Phone 496-2125 DCRT, Anne P. Enright Fax 402-1485 Hoang Le, Dionisio Rubi, Jorge Rubi, Rachel DRG, N. Sue Meadows Sherman, ]oner Tomas, and Sovanrith Tun Editor FIC, Jim Bryant (Laboratory of Central Nervous System Richard McManus NCI, Patricia A. Newman Studies); Meira Cohen (Neuroimmunology NCHGR, Leslie Fink Branch); Wendy Davis (Epilepsy Research NCNR, June Wyman Assistant Editor NCRR, Polly Onderak Branch); Penelope Kuhn (Laboratory of Viral Anne Barber NINDS awardees Rachel Sherman and Sovanrith NEI, Linda Huss and Molecular Pathogenesis); Wei-Han Henry NHLBI, Louise Williams Fang (Clinical Neuroscience Branch}; Jeanne Tun worked on illnesses of the nervous system. Staff Writer NIA, Vicky Cahan Steppe! (Laboratory of Neural Control); and Carla Garnett NWD, James Hadley Desiree Wilson (Contracts Management NIAMS, Amy Iadarola Branch). Shingyee Huang (Experimental Therapeutics NICHD, Carol Florance Editorial Assistant Students receiving Letters of Commendation Branch}; Lester Hui (Laboratory of Neuro­ NIDCD, Gail Blatt Marilyn Berman NIDDK, Eileen Corrigan included: Ali Al-Attar, Michael Day, Dawn chemistry}; Maurice Johnson (Grants Manage­ ry ment Branch); Dung Le (Epilepsy Research NIDR, Mary Daum Dew, Lia Haynes, B an Klepper, Amir NIEHS, Hugh J. Lee Branch}; Eric Bradburn and Jennifer Porter reserves che right to Moinfar, Mary Ellexson-Nino, Jonathan Thr NIH Rtcord NIGMS, Wanda Warddell (Neuroimmunology Branch); Gerardo Gonzalez make corrections, changes, or deletions Pirnazar, Christian Romero, and Christopher in submitted copy in conformity with NINOS, Carol Rowan (Neuroimaging Branch); and Hung Tran and the policies of the paper and HHS. NLM, Roger L. Gilkeson Tyrrell (Laboratory of Central Nervous System ry Studies}; Michelle Bishop, Catherine Palmer, Makoto Yoshino (Laborato of Neurophysiol­ and Nina Robin (Medical Neuroloey Branch); ogy). 0 The Record page 3 September 29, 1992

Accessibility Is Theme of Disability Awareness Program Eggers Continues NCHGR Lectures Baltimore TV consumer reporter Jayne Miller, with Disability Act of 1990. She has extensive and a leading spokesman for people with experience designing, implementing and The NCHGR's 1992-93 Human Genome disabilities, Dr. Susan M. Daniels, will headline managing programs benefiting citizens with Lecture Series continues this month with a NIH's 10th annual Disability Employment disabilities. presentation by Dr. Mitchell Eggers on Awareness Program on Thursday, Oct. 15, from Jorge Urrutia, director of the Division of "Genosensors: Microfabricated Devices for 11:30 a.m. to I :30 p.m., Wilson Hall, Bldg. 1. Engineering Services at NIH, addresses this Automated DNA Sequence Analysis," on Oct. Miller is the consumer advocate reporter for year's theme, "Accessibility: The Key to 15 in Lipsett Amphitheater, Bldg. I 0, at noon. "Eleven On Your Side" on WBAL-TV Channel Opportunity," in his opening remarks, and Eggers is currently head of the bioelectronics 11 in Baltimore. Her investigative reporting Diane Armstrong, director of the Office of division at the Houston Advanced Research has earned many honors including the National Equal Opportunity, presents special awards to Center, which is developing technologies that Headliner and Associated Press awards for NIH employees and others in the community will aid in DNA sequencing. He has also been reporting on the handling of child abuse cases, who have contributed greatly to furthering associated with Rice University as an adjunct and United Press International and Society of employment and accessibility for persons with associate professor since 1991. He received his Professional Journalist awards for her stories on disabilities. undergraduate degree in electronic engineering emergency preparedness at Baltimore-Washing­ Dr. Ronald Geller of NHLBI, who chairs the from Texas A&M University in 1980, his M.S. ton International Airport. NIH advisory committee for employees with degree in 1981 and Ph.D. degree in I 984 from Daniels, who has a Ph.D. in educational disabilities, will report on recent progress and the same institution. psychology with an emphasis in disability future effortsto meet the needs of disabled From 1985 to 1990, Eggers was on the staff of studies, is associate commissioner of the HHS workers at NIH. Massachusetts Institute of Technology's Lincoln Administration on Developmental Disabilities. All NIH employees are invited to attend the Laboratory, where he founded and directed a She served on special assignment to the program and reception that immediately multidisciplinary basic research project for President's committee on employment of follows. Sign language interpretation will be investigating the properties emergent from people with .disabilities during the final legisla­ provided. For reasonable accommodation networks of brain cells grown, differentiated, tive phases leading to passage of the Americans needs, call 496-2906. 0 and synaptically interconnected on fabricated biochips. His lecture will include discussion of the development of electronic devices that link Bethesda Businesses Unite in Fundraiser To Help Children's Inn biological phenomena to electronics, specifically The business community of Bethesda has for dollar, any proceeds above $10,000 gener­ forbiotechnology and biomedical applications combined forces for the second year in a row to ated by the event, said inn spokesman Judy such as DNA sequencing. For more informa­ offer "Come Back to Bethesda," a day-long Immerman. tion or to schedule an appointment with Eggers, festival on Saturday, Oct. 3 benefiting the Acting as emcees for Come Back to Bethesda contact Dr. Carol Dahl, 402-0838. 0 Children's Inn at NIH. '92 will be radio personalies from XTRA I 04 .1, Last year's function, hosted by Chevy Chase whose reporters have interviewed inn Executive NAEP Sponsors First National Chevyland, brought $10,000 to the inn. That Director Robert Gray, and Randy Schools, Asthma Management Conference day included a hot rod show, a special showing general manager of R&W. of the film American Graffiti and an evening "Last year we were trying to raise awareness of Asthma has been increasing in frequency and dance. the inn, and raise funds," said Dabney. "This severity nationwide and worldwide. Yet, with On Saturday, Oct. 3, Come Back to Bethesda year we're able to raise more money. We hope proper management, most asthma patients can '92 will again feature the free exhibit of custom to do even better next year." lead normal lives. cars, street rods and trucks at the Chevyland For information about the fundraiser, call On Oct. 11-13, the National Asthma Educa­ show room and lots, a showing of American Dabney, 657-4000. 0 tion Program's (NAEP) coordinating committee Graffiti (at Bethesda Cinema and Drafthouse) will host the "First National Conference on and a fifties-style sock hop from 7 to 11 p.m. Asthma Management" at the Hyatt Regency Children's Inn Tours Available featuring the Legendary Orioles. Crystal City in Arlington, Va. Tours of the Children's Inn at NIH are now "We hope to raise at least $23,000 for the The NAEP is coordinated by the National available to the public on the second Wednes­ Children's Inn with this year's event," said Dave Heart, Lung, and Blood Institute. Its coordi­ day of each month, from 11:30 a.m. to I p.m. Dabney, manager of Chevyland. "The business nating committee brings together 32 voluntary Both private quarters and community areas of community in Bethesda has again united for a health, professional, and medical organizations the inn are part of the tour. true celebration of nostalgia, and to benefit the from the public and private sectors. The From its state-of-the-art playground and children at NIH." landmark event represents the first time that so garden to its homelike interior, the inn Host sponsors, who have contributed gifts of diverse a group has converged to grapple solely provides a nurturing environment for children $2,000, include Chevyland, GEICO, Hot with the problems of asthma management. being treated forcritical illnesses at NIH and Shoppes, Bell Atlantic Mobile Systems, and the The meeting's agenda of plenary sessions, their families. The 2-year-old facilityhas two Bethesda Urban District. Seventeen other roundtables, and workshops will cover such double kitchens and dining areas, living room, corporate sponsors, including the NIH Federal topics as: the latest findings on the disease's game room, play room, computer room, Credit Union, have given $500 each. Dabney inflammatory basis; epidemiological trends; library, quiet room, and laundry room, and hopes the sock hop will generate another clinical updates; peak flow monitoring; health can accommodate up to 36 families.The inn's $7,000. care barriers; child and adult patient education; purpose is to keep a family together in the Raffle prizes at the event include a deluxe allergens; pharmacology; cultural influences; midst of medical crisis, reduce stress, and getaway for two from J&D Travel Associates, management in schools; immunotherapy; high promote self-help and mutual support. Inc., and tickets to Redskins, Bullets and risk patients; asthma and sports; and emergency A volunteer will be on hand to answer Capitals games. care. questions during tours. To schedule one call Merck & Co. Inc., which donated the money For more information, phone (301) 951-3275 Judy Immerman, 496-5672. that built the inn, has offered to match, dollar or fax (301) 951-3269. 0 The Record page4 September 29, 1992

CONTE (Continued from Page 1) Seven Institutes To Share Space

Seven research institutes at NIH will "He'd be on the phone right away to his best occupy space in the Silvio 0. Conte Bldg., friend, (former Speaker of the House) Tip also known as Bldg. 49. They are NICHD, O'Neill. 'Tip,' he'd say, 'You should see it. NIMH, NINDS, NIAAA, NEI, NIDR and They're dedicating a $72 million research NIA. The following units within these facility co me and it's the most unique building institutes will locate there: in che world. Tip, it's the best, the NIH NICHO-Laboratory of Developmental director Dr. Healy cold me so."' Neurobiology, Laboratory of Cellular and Conte's greatest pride was the NIH, according Molecular Neurophysiology, Endocrinology co Early. "He called NIH the finest research and Reproduction Research Branch, Section facility in the world. He'd be the first to say it's onGrowth Factors. not the buildings chat make it so great, buc the NIMH-Division of Intramural Research people you put inside chose buildings ...We have Rep.Joe Early (D-Mass.) was a friendof Contes Programs, Laboratory of Neuropsychology, co continue co give NIH the cools it needs co do and remembered the enthusiasm his colleague Clinical Neuroscience Branch, Veterinary the job." always had about NIH research. Having an NIH Medicine and Resources Branch. Remembering Conte as a lively hunting building named after him was Contes greatest NINDS--Centerfor Neurogenetics, companion and devout Catholic was his friend professionalpride, he related. Central Nervous System Implantation che Rev. William George ofGeorgecown Program, Laboratory of Molecular and University, who recounted instances of"Sil's" Cellular Neurobiology, Laboratory of Neural joy in living. Control, Neural Systems Section. "When Sil was being created here at NIH and "You won't be haunted by Sil," offered NIAAA-Laboratoryof Molecular and knew he was dying, he never lost his passion for George."The sign you installed is big enough Cellular Neurobiology, Laboratory of work or for hunting. Even when his blood for his ego." Neurogenetics, Laboratory of Membrane George said the key to Conte's effectiveness in Biochemistry and Biophysics, part of Section Congress was his knowledge of strategy: "He on Neurochemistry and Neuroendocrinology. knew how Congress worked and he loved it. NEI-Veterinary Research and Resources He had tremendous respect for his colleagues, Section (NE! is lead NIH institute for even his enemies. He did wonderful things to managing Bldg. 49's state-of-the-art animal bring humor co the floor (of Congress)." facility), Laboratory of Sensorimotor Re­ George concluded by remembering Conte as search. fundamentally "a very simple, sincere man NIDR-Neurobiology and Anesthesiology when it came co piety. Underneath it all, he Branch. was a simple man of faith. He could be difficult NIA-Section on Cerebral Physiology and sometimes, but he was a really fun man." Metabolism of the Laboratory of Neuro­ Corinne Conte, who attended with two of sciences. their daughters, remembered that her husband Photos: John Crawford "loved life, and he loved you at NIH, and all the people. To this day, I'm finding out so many things Silvio was involved with that I Corinne Conte addresses the audience on Sept. 17. never knew about-things that are good for She is still discovering many ofthe good works her people, especially chose in need of medical care. husband accomplished on behalfof Americas "He always said NIH was the jewel of the medical mearch effort, she said. medical profession. Today I can say chat one of the stars in NIH's crown is the fact that this building is named for him. Another scar in the crown is the Decade of the Brain, which he counts were very low and he was tired, he supported so strongly. I know there will be so continued co work, thanks co che help of his crackerjack staff." George said Conte once came co the Clinical Enjoying the reception following the building Center in full hunting regalia co gee a refill on a dedication were NICHD director Dr. Duane pump he wore that delivered chemotherapy. Alexander and Rep. Connie Morella (R-Md.). "We were going to shoot quail and pheasant, NICHD will be among seven institutes sharing and he comes striding in with chis big orange space in Bldg. 49, which will be the site ofresearch hunting whistle around his neck, for calling the on child health and the neurosciences. dogs out in the field. One of the nurses asked what the whiscle was for and requested a demonstration. Well, Sil didn't just give a quiet toot, he let om a full blast." many good things that will come forth from the doctors' research here." George also recalled that when Conte would The Rev. William George of Georgetown Univer­ "This building will stand as a perfect testa­ leave the CC, named after Sen. Warren Grant sity was a friend and hunting partner of Conte's. ment to his life," said NIH director Dr. Magnuson, he would point to the modest Here he gestures toward the si out front of the gn Bernadine Healy, who remembered in Silvio plaque in the lobby bearing the former Wash­ new building, which Conte insisted be large Conte"a legacy of love and service chat will ington state lawmaker's name and say, "] ust be enough that people recognize it. sure the sign on my building is bigger than forever enrich this country. He brought the chat." passion of his Italian heritage to his concern for The Record page 5 September 29, 1992

the health of America's children ...Silvio Conte's Avoid the Flu-Get Vaccinated This Fall at NIH family was America." Healy gave details of Conte's biography-his Although fall has just begun, ic is time to first career as a machinist, his Navy service as a prepare for the upcoming flu season. Now is Seabee, and highlights of his legislative tenure. Influenza Immunization Schedule the time to consider vaccination to protect She concluded with advice to the 550 workers yourself from influenza, because the vaccine Bldg. 10, Clinic 6: Oct. 6.-Nov. 13 from seven institutes who will occupy the 8- takes a few weeks to produce immunity. Rm. 6C306 story building, beginning late this year: "Make The Occupational Medical Service (OMS) A-B-C Oct. 6 7:30-11 a.m., 1-2 p.m. haste carefullv, but make haste-Silvio is will provide free flu shots to NIH employees watching." D-E-F Oct. 8 7:30-11 a.m., 1-3 p.m. between Oct. 6 and Nov. 13. Even if you have Following the remarks, guests, who had been Oct. 27 7:30-11 a.m., 1-2 p.m. been vaccinated in the past, previous influenza entertained by performances of the U.S. Marine vaccination does not provide protection against G-H-1 Oct. 28 7:30-11 a.m., 1-3 p.m. Band, watched as Mrs. Conte unveiled a sign this year's influenza strains. Annual vaccina­ and plaque, cut a ribbon, then entered the new tions are needed. J-K-L Oct. 13 7:30-11 a.m., 1-2 p.m. facility for a reception and tours. D Vaccination may prevent or reduce the M-N-O Oct. 14 7:30-11 a.m., 1-3 p.m. NIEHS Centers Program severity of infection with influenza and also Nov. 3 7:30-11 a.m., 1-2 p.m. Has 'New Directions' decreases the opportunities for spread of this virus among patients, visitors and colleagues. P-Q-R Nov. 5 7:30-11 a.m., 1-3 p.m. NIEHS is making changes in its Centers The noninfectious vaccine will not cause Program to integrate basic research programs influenza. Individuals who are allergic to eggs S-T-U Oct. 20 7:30-11 a.m., 1-2 p.m. with the institute's new directions in public and eggproducts should not receive the vaccine. health and the environment. The changes are V to Z Oct. 22 7:30-11 a.m., 1-3 p.m. The vaccine is considered safe for pregnant Nov. 10 7:30-11 a.m., 1-2 p.m. being implemented through new guidelines that women, but pregnant women in their first will strengthen basic research components as trimester may wish co consult their physician Make-Up Day, Nov. 13 8-11 a.m., 1-3 p.m. well as bring new activities of outreach and before immunization. education into the centers for the first time. Immunization is even a higher priority for Evening Clinics will be held on Mondays and Wednes­ The mission of the institute-to understand some individuals: days, 6-8 on a first-come, first-served basis. the contribution to human diseases of chemicals eHealch-care workers and support staff, and physical factors in the environment-cuts especially those who have contact with patients Bldg. 13, Rm. G-904 across diseases of interest to many other NIH and other employees who routinely visit che A-B-C Oct. 23 8-11 a.m., 1-3 p.m. institutes and therefore requires collaborations Clinical Center; among both staff and grantees. This is particu­ G-H-1 Oct. 9 8-11 a.m., 1-3 p.m. ePersons larly evident in the Centers Program, directed age 65 or older; J-K-L Oct. 30 8-11 a.m., 1-3 p.m. by Dr. Christopher Schonwalder of the ePersons with chronic cardiovascular, Division of Extramural Research and Training, pulmonary or metabolic disorders, kidney P-Q-R Oct. 16 8-11 a.m., 1-3 p.m. which provides support to bring together the disease, anemia; interdisciplinary research activities needed to 8-11 a.m., 1-3 p.m. ePersons who are immunocompromised. S-T-U Nov. 6 study problems of environmental exposure and disease. In order co accommodate employees in a more The new guidelines require a minimum of $1 time-efficient manner, OMS will be imple­ Off-site facilities listed below, first-come, first-served basis: million in existing peer-reviewed research menting a new schedule based on the first letter support related to environmental health of your last name and extending the flu clinics sciences. Most, but not all, of this research by 2 weeks. See the schedule for a convenient EPN, Rm. 103 Oct. 15 8:30-11 a.m. would be supported by NIEHS through other time and place; no appointments are needed for Oct. 29 8:30-11 a.m. mechanisms. these clinics. If for some reason you cannot Nov. 12 8:30-11 a.m. The center grant provides support for various make the assigned day, you can attend any Federal Bldg., facilities and will also provide funds to develop other clinic at OMS to receive your vaccine. Additional information can be obtained from Rm. 10-B08 Oct. 15 1-3 p.m. community outreach and education research, to Oct. 29 1-3 p.m. explore new research directions, and to respond the Occupational Medical Service (496-4411) immediately to the public health implications or the Hospital Epidemiology Service (496- Poolesville, Conf. Rms.: of environmental incidents such as spills, leaks, 2209). Employees will be asked to complete a Bldg. 102 Oct. 21 9-11 :30 a.m. or other situations causing public concern. short questionnaire to help OMS/HES improve Bldg. 110 Oct. 21 1-3 p.m. NIEHS anticipates that these new programs the response of employees in receiving the influenza vaccine. Westwood Bldg., Rm. 11 Oct. 19 8:30-11:30 a.m. will promote individual actions to avoid Oct. 26 1-3 p.m. unhealthy exposures to environmental agents or The CC administration strongly encourages Nov. 2 1-3 p.m. reduce the potential for disease and disorders all NIH workers to obtain the vaccine. resulting from the unavoidable exposures inherent in today's society, such as air pollut­ lmmunosuppression Is Topic of NIAID Symposium, Oct. 23 ants. The centers will also be a resource for dealing with local environmental concerns by An NIAID symposium on immunosuppres­ cally mediated diseases and transplantation. providing expertise on current issues in sion in the treatment of disease will be held on Cosponsoring the CME-accredited event is the environmental health and educational outreach Friday, Oct. 23 from 8:30 a.m. to 5 p.m. in American Academy of Allergy and Immunol­ at the local level. Currently the institute funds Masur Auditorium, Bldg. 10. It will discuss ogy. Registration deadline is Sept. 30. For 13 Environmental Health Sciences Centers che state of the art in the use of immunosup­ information, contact Dr. Howard Dickier, 496- throughout the country. D pressive agents in che treatment of immunologi- 7104. D The Record page6 September 29, 1992

CELLBANK (Continued from Page 1) during the 1950's and 1960's, Scientists were doing more research involving cultured cells, but this required them to locate cell donors­ no easy task if a study involved a rare disorder. Often, researchers obtained cell samples from other scientists, but there was no guarantee that shared samples were free of contamination, or even that they were identified correctly. Scientists who used cultured cells during the years before the repository was created tell rueful stories of puzzling findings-and wasted time-attributed to contaminated or misidentified cells. Dr. DeWitt Stetten, Jr., who was NIGMS director from 1970 to 1974, realized that a response to this situation would be to establish a The staffof the Coriell Institute forMedical Research includes (from l) founderDr. Lewis L. Coriell; collection of cell cultures for use by any SelenaDwight, research associate who has trained and supervised numerous cell culture technicians; qualified scientist. In 1972, NIGMS awarded a recently retired director Dr. Arthur E. Greene; and current director Dr. Richard A. Mulivor. contract to the Coriell Institute for Medical Research in Camden, N.J., to establish the cell Establishing Cell Lines tion on the original diagnosis, the laboratory repository. Over the years, other PHS compo­ It takes considerable expertise and time to that submitted the cells, the original literature nents, including NINDS, NIMH, NIDDK, establish a cell line. Cultures must be carefully citation, the number of cell generations or and NIAMS, have contributed to the support of characterized, able to grow, and free of contami­ population doublings since the culture was special repository collections related to their nauon. established, and the chromosomal location or research interests. In the early years of the repository, most of biochemical characterization of the genetic During its first year of operation, the reposi­ the cells stored were fibroblasts, which are defect. tory established 139 cell lines and shipped 144 obtained by taking a small sliver of skin from a Cell lines in the repository are cross-referenced cultures to researchers. Since then, it has donor's forearm. Today, a substantial portion with the Online Mendelian Inheritance in Man processed more than 10,000 submitted speci­ of the cell lines are derived from white blood database, and efforts are under way to cross­ mens and provided more than 58,000 cell cells. Other cultures are grown from cells in reference the collection with the Genome cultures to investigators. The collection now chorionic villus or amniotic fluid samples. Database, as well. includes 5,270 cell cultures, representing 364 Once at the repository, the sample is placed in Each year, NIGMS publishes a printed well-defined genetic disorders. There is a culture flasks containing growth medium and, version of the repository's database as a catalog modest charge for each cell line requested. as needed, other factors that stimulate growth. of available cell lines. As the collection has The collection contains cells with every After 3 to 4 weeks in an incubator, the multi­ grown, so has the catalog-to the point that it known type of chromosomal abnormality, plying cells are transferred to additional flasks to now has reached telephone-book size. To save including deletions, additions, inversions, continue their growth. Meanwhile, the cells go printing and mailing costs, several years ago translocations, and "fragile sites" where breaks through dozens of tests to make sure that they NIGMS began producing a full catalog every are likely to occur. There are cells with are not contaminated by microorganisms, other year, and a supplement in the intervening identified biochemical defects, such as those including bacteria, yeast, fungi, and myco­ years. The latest catalog is likely to be the last, from people with Tay-Sachs disease, and cells in plasma. About 2 months later, when enough however, as work has begun to provide the which the biochemical defect is still unknown, cells have been accumulated, the cells are database via online access. as in Huntington's disease. harvested, apportioned into ampules, and stored Recently, the repository began offering DNA New Service r in liquid nitrogen at a temperature of -196 purified fom selected cell lines. According to degrees Centigrade until they are requested for In 1990, the repository began offering DNA repository director Dr. Richard A. Mulivor, research. When properly thawed, these living from rodent-human hybrid cell lines, in providing DNA "saves researchers the time, cells resume their functions and begin to addition to cell cultures from these lines. These equipment, and expense required to perform multiply again. cell hybrids have been used in genetics research the extraction themselves." The repository "The cell lines, which have been referred to as for more than a decade. When human and currently has DNA from 275 cell lines available, our 'frozen assets,' are not a Noah's Ark of rodent cells are fused, the hybrid cells contain and has already sent out 4,500 samples to genetic diseases or museum specimens; they are all the chromosomes of both species. As the investigators. a vital national resource," says Mulivor. "The cells grow and divide, most of the human The repository also has cell cultures from staff of the repository is proud of its contribu­ chromosomes are gradually lost, for reasons that extended family pedigrees, which are valuable in tions in the application of cell culture tech­ are not clear. Eventually, a given hybrid cell genetic linkage studies, and a small collection of niques to the detailed study of human genetics, line will contain just one or a few human cell cultures derived from diverse human which has led to a wealth of information about chromosomes. populations such as Amerindians, Melanesians, metabolic disorders and gene abnormalities." A gene mapper can take a stretch of human and Pygmies. DNA of unknown chromosomal origin and Among the most commonly requested cell Comprehensive Database apply it to, for instance, a hybrid cell line lines are those with chromosomal abnormalities, The repository maintains a comprehensive known to contain only human chromosomes 1 those from the Utah and Amish pedigrees, and computer database that contains records on and 3. If the applied DNA is complementary in those from individuals with xeroderma individual cell lines and a bibliography of sequence to any portion of either of the human pigmentosum, cystic fibrosis, ataxia­ publications citing cell line use. With each cell chromosomes, it will bind to the complemen­ telangiectasia, and Fragile X syndrome. line they request, researchers receive informa- tary sequence on the intact chromosome and The Record page 7 September 29, 1992

can later be detected. In one step, the re­ mapping. Second, and at least as important, is on cell lines with mutations that are well-defined searcher has narrowed the search for the DNA's the fact that the repository will accept valuable at the DNA level," Greenberg says. "For chromosomal origin from any one of 24 cell lines from my laboratory for permanent example, the repository has 21 cell lines contain­ possible chromosomes to only two. storage-and who hasn't ever had a freezer ing distinct, molecularly characterized cystic Rodent-human hybrid cell lines are notori­ break down and lost critical cell lines? The fibrosis mutations, as well as cell lines containing ously unstable, however, and are also not useful repository will also aid in the distribution of thalassemia mutations. These are valuable for for gene mapping unless the researcher can be these materials to other interested laboratories, diagnostic work, and also to correlate various sure exactly which chromosomes they contain. eliminating a substantial workload from my defects with the severity of the disorder." In The repository has addressed both of these lab." research on cystic fibrosis, the repository issues in developing two hybrid panels, one Future Directions collections are expected to aid the search for the containing cell lines with from one to 19 Among the repository's newest initiatives is mutations responsible for about 30 percent of human chromosomes in each and one contain­ the acquisition of all cell lines from the French the cases. Greenberg adds that the repository is ing cell lines with one or two human chromo­ Centre d'Etude du Polymorphisme Humain working to characterize similar cell lines for somes. The scientific community has re­ (CEPH). This collection includes more than other diseases, such as Fragile X syndrome. sponded enthusiastically to the availability of 800 lines from about 60 families, and is "very According to NIGMS director Dr. Ruth L. the somatic cell hybrids, which have rapidly useful for linkage analysis," notes Greenberg. Kirschstein, who took her position when the become among the most frequently ordered cell Using the CEPH lines from the NIGMS repository was just 2 years old, "The repository lines in the repository. repository, investigators will be able to obtain is a dynamic resource that has continually "Now that we have these panels, the next larger amounts of DNA than are available from evolved to meet, and even anticipate, the thrust is to create chromosome-specific panels," CEPH itself, and will also be able to look at changing needs of research scientists, and there says Dr.Judith Greenberg, director of the ceHular characteristics that cannot be studied by is every reason to expect that it will continue this NIGMS Genetics Program and project officer examining DNA. record of responsiveness in the future." D for the cell repository contract. "These panels "Another fairly new, and growing, emphasis is would include hybrids containing portions of specific chromosomes, and would be useful for NIH Introduces TRANSHARE Program, Subsidizes Employees' Commutes regional mapping studies. Eventually, we NIH recently launched its TRANSHARE be selected by lottery. would like to have a regional mapping panel for Program, a subsidy program to encourage The ultimate goal of TRANSHARE is to each chromosome." Greenberg adds that the employees to use public transportation. It will relieve traffic and parking congestion on repository is trying to work closely with the be run by the Office of Research Services, campus and surrounding roadways. For more chromosome groups organized by the interna­ Division of Security Operations, Employee information about the TRANSHARE pilot, call tional Human Genome Organization to Transportation Services Office (ETSO). ETSO, 402-RIDE. identify and acquire panels that are of the TRANSHARE will begin as a 1-year pilot greatest utility to the gene mapping commu­ program of 2,000 employees subsidized up to nity. $21 a month in fare media for using public Input from the Scientific Community transportation. The Bldg. 31 R&W gift shop In addition to Greenberg's supervision of the will distribute the subsidies to participants in repository's operation, a committee of outstand­ the form of Metrorail farecards, Metrobus UNCLESAM ing scientists advises NIGMS on the tokens, Ride-On tickets and commuter coupons repository's progress. The advisory group also for the MARC trains. Employees must predicts areas of future scientific need and relinquish their on-campus parking permits to makes recommendations for the acquisition of participate in TRANSHARE. WANTSYOU new cell lines, the deletion of cell lines from the The future of the government-wide subsidy collection, and related matters. The advisors program, which includes TRANSHARE, include experts in medical genetics, cytogenet­ depends on the success of this and similar ics, population genetics, molecular genetics, programs. The legislation that authorizes the somatic cell genetics, and database manage­ subsidy expires December 1993. Renewal of ment. the law depends on recorded successes of all The repository also relies on investigators to subsidy programs. submit specimens for inclusion in the collec­ In particular, the success of TRANSHARE tion, as well as on curators who analyze cell hinges on whether it effectively mitigates on­ cultures for specific biochemical and chromo­ campus traffic concerns. Regardless of the somal abnormalities. renewal of the subsidy law, NIH must prepare a Greenberg stresses that the repository "could report for the DHHS beforecontinuing beyond not have flourished during the past 20 years the pilot. If approved, NIH plans to expand without the generosity and cooperation of the the program and include on- and off-campus many members of the scientific community employees subject to available funding in fiscal who have served as advisors and curators and year 1994. who provided the samples from which the cell For employees whose commute route to NIH lines were established." is convenient to the Shady Grove Metro Dr. David Ledbetter of Baylor College of Station, TRANSHARE is enhanced by the Medicine, who chairs the advisory group to the availability of a satellite parking lot there. In y surrendering on-campus parking permits for TO RIDE repositor, says that the repository "serves two important functions for me as a biomedical guaranteed Shady Grove parking spots, employ­ researcher. First, it is a tremendous resource for ees automatically qualify for TRANSHARE. obtaining cell lines with genetic and cytogenetic Should demand exceed supply during the pilot program, TRANSHARE participants will METRO abnormalities for experimentation and gene The Record page 8 September 29, l 992

NURSING RESEARCH (Continued from Page 1) HIV drugs, the disease itself, or both. Re­ searchers also are hoping to learn how the myopathy responds to changes in HIV treat­ more livable, helping them to feel and function ment-for example, lowering AZT doses or better or to cope with a chronic illness and its Problemsstopping thewith medication HIV Medication for a time. treatment." That orientation is clear in the intramural program's current portfolio. Three projects, all A third study is evaluating patient compliance at the Clinical Center, deal with problems with three drug treatments-interferon alone, experienced by people who are HIV-infected as AZT alone, and AZT plus interferon-in an they undergo treatment for the disease. Beyond NIAID clinical trial. The study is conducted in the CC, NCNR researchers in Hawaii are collaboration with an NIAID nurse. studying caregiver burden and quality of life of "This is a particularly interesting study women who care for older men with dementia, because patients are essentially feeling well, but as part of NHLBI's Honolulu Heart Study and are being asked to take drugs that might make NIA's Honolulu Aging Asian Study. At NIA's Dr. MaryRopka reviews body composition them feel bad and interrupt their attempts to Gerontological Research Center in Baltimore, information obtained by bioelectrical impedence live a normal life," said Ropka. Nurse research­ nurse researchers are examining how to manage analysis during the HIV nutrition study. ers would like to know what personal, health, urinary incontinence, limited mobility, and and treatment factors contribute to patients' other common problems of older people. problems with taking their HIV drugs as Collaboration with other health disciplines is prescribed. a key feature of the NCNR intramural program, What motivates patients to participate in this Results of all three HIV projects are expected which operates by adding a complementary research, which promises no immediate to yield knowledge that will help make life more nursing research component to established NIH individual benefit? "Some are genuinely liveable for people with HIV. D projects. Currently, NCNR staffare working interested in things like whether they have NHLBI Symposium on Oct. 15-16 with intramural nurses and scientists from elevated triglycerides and how much body fat Honors Gardner McMillan NIAID, NIA. NHLBI, and NINDS, as well as they have," Ropka said. "Others believe that by nurses, dietitians, and investigators from the participating they will help someone someday." CC. For example, HIV-infected people who Results of the research will shed light on when NHLBI will host a special symposium on come to NIH to participate in NIAID clinical and why nutritional problems occur, and help atherosclerosis Oct. 15-16 to honor Dr. trials are invited to participate in NCNR's Muscleidentify Weakness who is at risk. Gardner McMillan, former director of its AIDSstudies and of nurritionQuality of and Life myopathy. Arteriosclerosis, Hypertension, and Lipid Metabolism (AHLM) Program. A second study evolved from clinical observa­ The symposium, to be held in the Clinical Because HIV infection is no longer rapidly tions of a new problem in HIV-infected Center's Masur Auditorium, will bring together fatal, patients infected with the virus are living patients: myopathy, or muscle weakness. experts from around the country to explore the long enough to develop chronic problems that Several questions arose: Are there actually latest research findings about the pathobiology interfere with their daily lives. Eating is one of physiologic changes in muscle tissue? When and associated risk factors of atherosclerosis. those problems. does this happen? How does it affect people's Topics will include endothelial dysfunction, Nutrition-related problems can include ability to function? lipoprotein receptors, oxidation and free fatigue, nausea and vomiting, oral lesions, Bob Wilson, for example, suffered from radicals, monocytes, growth stimulatory and weight loss, difficulty in swallowing, diarrhea, extreme fatigue, weakness, and pain in his inhibitory molecules, cytokines and monokines, and fever. These are caused either by the muscles and joints after taking AZT for awhile. smooth muscle diversity, immunity, matrix disease itself or by drugs that attack the virus or "At the time I was a designer, and I spent all molecules, platelets and coagulation, associated opportunistic infections. NCNR day on my feet," he said. "It was very painful." thrombosis, hypertension, diabetes, and research nurses are studying what nutritional Asked to participate in the myopathy study, he genetics. Also, special sessions will feature a problems occur, what causes them, and how agreed because of the chance to learn more look back and a glance ahead at the past and these problems affect immune function in about his problem. Although Wilson suspects future of atherosclerosis research. various stages of HIV infection and different his myopathy is a side effect of AZT-he had The symposium honors one of the pioneers in HIV treatments. more energy when he stopped taking the drug atherosclerosis research. McMillan, who retired While they are enrolled in the study, patients temporarily-researchers are unsure how as AHLM director in 1991, advocated seeking a keep food intake records and undergo several myopathy is related to AZT, other drug multiple explanation for atherosclerosis and tests that measure body composition including treatments, and the virus itself. conducted key research in the field. One of his height, weight, body fat, and lean body tissue. To find out, NCNR scientists are studying 25 studies showed that the amount of cholesterol Patients get copies of these body composition HIV-infected people for 6 months. Like in atherosclerotic lesions did not match their analyses, as well as printouts showing their food Wilson, patients are interviewed and fill out severity. He also coauthored with Dr. George and vitamin intake compared with recom­ questionnaires each month about how muscle L. Duff of McGill University a paper on mended nutrient allowances. If they are losing weakness affects their normal routines. Their atherosclerotic lesions that has been the weight-as happens in sicker patients with strength and endurance are evaluated in clinical standard reference since 1951. chronic diarrhea-a dietitian meets with them exams and tested in timed activities-for A transplanted Canadian, McMillan joined to see how they can change their diet to gain example, how long it takes to get up from a NHLBI in 1966. His productive career weight. Blood samples are analyzed for viral prone position and a chair, climb stairs, walk 30 resulted in nearly 80 scientific publications and activity and immune function. feet, and lift weights. Finally, muscle biopsies earned him numerous honors, including the Of 120 patients in the study, most are men, are done to evaluate the effects of HIV and drug 1977 NIH Director's Award. although there are 14 women. Their ages range treatments on muscle tissue. For more information on the symposium, from 19 to 55. Although all are HIV-infected, Results of this study are expected to suggest to contact Louise Duvall, 496-9899; to register, they may or may not have AIDS. what extent myopathy is related to certain anti- contact Carol Sadler at (301) 468-MEET. D The Record page 9 September 29, 1992

New Genome Center Launches Fruit Fly Mapping Project A new, multi-campus research center based at do, and the technology they develop can be locate specific genes on chromosomes. the U niversicy of California-Berkeley will applied to mapping human genes." To make more detailed "physical" maps of the spearhead a project co map the fruit fly's Known to researchers by its scientific name, fruit fly genome, scientists at the new center will complete set of genetic instructions, known as Drosophila melanogaster, the fruit fly has been use bacterial virus vectors capable of holding a its "genome." The center will unify efforts co intensely studied by geneticists for over half a cloned piece of DNA about 100,000 base pairs map the animal's DNA and provide a central­ century. Modern geneticists have used the fruit long. By matching the overlapping sections of ized resource for technologies and materials co fly co learn how combinations of genes control the DNA pieces, the team will prepare maps of the large number of scientists studying genetics the head-co-tail and side-co-side development of DNA covering large portions of each chromo­ in the fruit fly. The maps of the fly genome the insect's body. More precise knowledge some. The relatively small size of the DNA will be unique in their ability co relate the about the genetic rules that govern how a body pieces in these vectors will allow scientists to physical location of genes on chromosomes to forms will provide researchers with new tools co begin sequencing the fly genome's 165 million their biological function in the organism. understand fecal development in humans and base pairs by adding some novel twists to The center "without walls" will be composed how errors in this process may result in birch efficient and widely practiced techniques. of four laboratories located at different sites. defects. By inserting so-called "jumping elements" Dr. Gerald Rubin, a respected fruit fly geneti­ In addition, says center director Rubin, "The into critical genes in the fly's genome, the cist and head ofU.C.-Berkeley's genetics information gathered on the fruit flyso fargives researchers will develop a set of mutations chat division, will serve as the center director. A scientists the best opportunity to combine will be useful in mapping a gene and, at the component at Washington University in Sc. knowledge about DNA sequence and gene same time, help to identify the gene's specific Louis will be led by Dr. Daniel Hard; Dr. Allan function in a complex organism." The maps function. The jumping gene will knock out the Spradling will head the component at the constructed by the center researchers will function of crucial genes necessary for the fly to Carnegie Institution of Washington (in provide a natural stepping scone into sequenc­ live. By studying these lethal alterations, Baltimore); and a component at the Lawrence ing the animal's DNA, Rubin says. researchers can draw conclusions about the role Berkeley Laboratory will be led by Dr. Michael A key reason why the fruit fly has been so of the mutated gene in a vital life process. At Palazzolo. valuable is because of its giant polytene chromo­ the same time, the investigators will map and "The researchers leading chis effort have a somes, found in cells of the insect's salivary catalog areas around the jumping genes. history of doing excellent science using the fruit glands. Each of these special chromosomes is Such information will also be valuable in fly, and they make their resources freely made up of just over 1,000 identical strands of deciphering the function of human genes. available to the rest of the community," says Dr. DNA, instead of the usual one strand. Each Many of the proteins in the fruit fly, such as Jeffery Schloss, program administrator at gene, therefore, is present 1,000 times and the receptors, regulatory proteins, and enzymes, are NCHGR. 'The maps generated by chis project copies are all lined up next to each other. This already known to have direct counterparts in will not only give researchers new opportunities alignment makes the chromosomes so large they humans, indicating chat important basic life co understand where genes are located but will can be seen under a simple microscope, a fact processes have been preserved during evolution. also facilitate learning what these genes actually that has been a boon to geneticists seeking to FlyBase: A DrosophilaDatabase � Computer Training Classes A 3-year grant has been awarded co support lected by Ors. Dan Lindsley and Michael Classes Dates the development of a relational database for Ashburner and others over many years and will Managing Data Effectively 9/30 Intermediate PC-DOS 10/1-10/2 the Drosophila genome. The database will be be continuously updated with new research Developing In-House Applications called FlyBase. When complete, FlyBase will findings," he said. on the Macintosh 10/5 serve as a resource for the genome research While the establishment and maintenance of Beyond Basic WYLBUR 10/5-10/9 communiry. FlyBase will greatly enhance the the curated databaseis the responsibiliry of all Analysis of Ligand Binding Data qualiry of accessing and handling the over­ four sites, each location will be responsible for Using the LIGAND Program 10/6 whelming amount of information about specific curatorial functions. The master OS/2 2.0 Overview 1017 database and major programs will be main­ Topics in Flow Cytometry 10/8-10/9 Drosophila. Introduction to MicrosoftWindows 10/13 There are four locations involved in the tained at Harvard Universiry, where much of PC<-> Mainframe Communication FlyBase project. Dr. William Gelbart, the programming effort will occur. The with ProComm Plus 10/13 professor of cellular and developmental biology U niversiry of Cambridge component, headed Getting Started with C 10/13-10/16 at Harvard Universiry, serves as the principal by Ashburner, will maintain the genetics tables GCG Sequence Analysis Under investigator. The coinvestigators are Dr. and will also be the European database server Unix on the Convex 10/14 Introduction to the Convex Supercomputer Michael Ashburner of the Universi of site for FlyBase. The component based at the 10/14 ry Enter BBS 10/14 Cambridge (Cambridge, UK); Ors. Thomas C. University of California, led by Merriam, will Developing Data Entry Applications Kaufman and Kathleen A. Matthews of maintain tables relating to the molecular with SAS/FSP 10/14 Indiana University (Bloomington, IN); and properties of genes. Kaufman and Matthews, Introduction to !SPF/PDF 10/15 Dr. John R. Merriam of the University of based at Indiana Universiry, will maintain Using Computers to Find California (Los Angeles). tables of strains from the two funded Dros­ Possible Regulatory Elements 10/15 Introduction to WYLBUR "In the past, dedicated volunteers from the ophilastock centers in the United States. 10/19-10/30 Introduction to Parallel Computing 10/20 Drosophilagenetics and molecular biology Gelbart, at Harvard Universiry, will maintain Running SAS Software in the research communiry have maintained and tables relating to mobile genetic elements and PC-DOS Environment I 0/20-10/22 distributed essential data resources for Dros­ genes introduced by germline transformations. Unix Commands 10/21 ophila genetics," says Dr. David Benton, These data tables will allow representation of Editing with Emacs 10/21 program administrator at NCHGR. "The up-to-date genetic and molecular maps of the Introduction ro Molecular Modeling I 0/22 rapid increase in the amount of available fruit fly genome. Programs integrating FlyBase Orientation to Running SAS on the Mainframe 10/26 DCRT Support for Unix Workstations at NIH 10/26 information now requires that a public with DNA and protein sequence databases will database be established. This database will be developed in collaboration with the Na­ Classes are offered by the DCRT Training Program incorporate the wealth of information col- tional Center forBiotechnology Information. without charge. Call 496-2339 for more information.□ The Record page 10 September 29, 1992

NATCHER (Continued from Page 1)

children, you continue to live in the strongest country in the world," he said, repeating words he has made famous over his years in public service, to the birthday gathering that included among other congressmen and high-ranking government officials, DHHS secretary Dr. Louis Sullivan, Interior Department Secretary Manuel Lujan, and the longest-serving (50 years, 5 months) member of congress, Rep. Jamie Whitten (D-Miss.), aOklahoma close friend of Natcher's. Paraphrasing a line from composers Rodgers and Hammerstein, NIH director Dr. Bernadine Healy said in opening remarks that in naming NIH's newest construction under­ taking after the Kentucky congressman, "We're only doin' awhat comes Natcher-ly." Though not geographically in the center of the country, Healy said, Kentucky represents the core of the union. On its northern border, the state touches the heartland of the Midwest; to the east, it NIH director Dr. Bernadine Healy leads the ceremonial hardhatcrew (from l) MarylandRep. Steny Hoyer, stretches deep into Appalachia; below, it Interior Secretary ManuelLujan, Reps. William Natcher ofKentucky and Jamie Whitten ofMississippi borders Tennessee, home of the Grand Ole and DHHS secretary Dr. Louis Sullivan in breaking ground forthe administration building that will Opry; and at its western-most tip, Kentucky reunite a largeportion ofBethesda-based NIH'ers currently working in rental properties.

Scheduled to house the extramural programs He shared the day with several family members for seven institutes and provide conference including his 19-month-old great granddaugh­ facilities for researchers, the $17 6 million ter, who he proudly said "demands all kinds of Natcher Bldg. will also reunite NIH'ers now housed in scattered rental properties with their ''Maythis building be filledwith colleagues at 9000 Rockville Pike, the hallmarks of hislife-a zeal for "This building certainly will be a beacon of enlightenment and of hope and of great good health and a fullness oflife. " Healy, DHHS secretary Dr. Louis Sullivan activity," predicted Sullivan, "not only for this (second from I) and birthday boy Natcher (r) share campus but also for our whole nation's bio­ a few moments with Rep. Steny Hoyer (D-Md.) medical research enterprise." The Natcher before the ceremony. Bldg., he continued, will go a long way toward special attention, and receives it." quickening and improving the process of health First elected to Congress in I 953, Natcher, a research, long-time NIH ally and ardent supporter of "Today is not only my birthday," said health research who is known for sponsoring "dips its toe into the Mississippi River, the Natcher, accepting accolades from the audience, biomedical funding legislation, has served 39 traditional border between east and west." "but it is one of the happiest days of my life." years through 8 presidents, 38 appropriations Kentucky has often been at the political DCB Pro· crossroads of the nation, she continued. "The Ject Offic fairness and evenhandedness for which Mr. Cl Yde Messerly Natcher is truly famous, I believe, derives in P hone: 301-4 part from his origins in the state that is both 96-23 DES Emergency geographically and politically NIHso central to this ''lone: 108 · nation." Like Kentucky, Healy said, also touches every corner of the country, funding research in every state in the U.S., with more than 24,000 researchNIH's grants at more than 1,800 universities and research institutions. Eighty percent of $9 billion budget is dispersed primarily in grants. 'The 3 I 8 acres, 50 buildings and I 6,000 employees here are only the tip of the iceberg," Healy said. "The country is our campus and Natcher, a longtime biomedical research advocate, recently celebrated his 83rd birthday at a groundbreak­ the Natcher Building will be the crossroads for ing ceremony here forthe NIH building named for him. that national campus," The Record page 11 September 29, 1992

committees and 7 NIH directors. "I can tell you that of the 7 NIH directors I've served with, I've found none more able, none more dedicated and certainly none more beautiful than Dr. Healy," Natcher said, recalling the support he has given and received from the Maryland delegation to Congress. "Thank you, especially my friendSteny Hoyer, Connie Morella and Barbara Mikulski and all those who marched with us every step of the way [through annual appropriations hearings]." The Natcher Bldg. is the second NIH edifice in recent years to be named for a congressman

Kentucky Sen. Wendell Ford (c) joined Healy, Sullivan (second fromI) and Rep. Louis Stokes of Ohio (r) to congratulatefellow Kentucky congressman Natcher on his 83rd birthday, which Natcher called "one ofthe happiest days of my life."

Photos: Bill and Ernie Branson from $73 million when he entered Congress in 1953 to nearly $9 billion in 1992, promised to see it reach $15 billion beforeSullivan leaves office. "You're all able people," Natcher said, commenting that the annual budget proposal hearings attended by Sullivan, PHS head Dr. James Mason, Healy and the institute directors are some of the nicest occasions in Congress. At those hearings, individual institute directors submit their "wish" lists for the upcoming budget season. "We admire you," continued the congressman. "We appreciate you ... and your , iilii':;� .·� testimony is always unusual. I serve on three Healyuses the enigineering model to point out subcommittees and when I use the word Healy(!) greeted several members of Congress who features ofthe new campus edifice that will house 'unusual,' I mean we agree with you." attended the groundbreaking forNatcher includ­ NIH'sextramural program offices, and a 1,000- In the opening moments of the program, ing Rep. Connie Morella, who represents seat auditorium and conference center. Chaplain Gary Johnston of the Clinical Maryland's district eight, where NIH is located. Center's spiritual ministry department, gave an who sits on the House appropriation commit­ invocation. His words also provided an renowned for his unique collection of ties­ tee; the Silvio 0. Conte Bldg., dedicated on appropriate benediction: "May this building with rwo birthday presents: a tie bearing an campus Sept. 17, was named for Natcher's that shall bear [Natcher's] name be filled with embroidered Natcher Bldg. and a framed ren­ Massachusetts colleague in the House who died the hallmarks of his life-a zeal for good health dering of the edifice. 0 of cancer last year at NIH. Natcher and Conte and a fullness of life." NCRR Cosponsors Symposium were great friends in addition to sharing Following the ceremonial groundbreaking NCRR's General Clinical Research Centers advocacy of health research-their committee where Natcher, Sullivan, Healy and members of Program and the University of Texas Southwest­ was known as the "Bill and Sil Show." Congress donned hard hats and picked up ern Medical Center at Dallas are cosponsoring a Natcher, who has seen the NIH budget grow shovels, Healy presented the honoree- symposium, "Techniques of Patient-Oriented Research," on Oct. 30-Nov. 1 in Dallas. The symposium seeks to better equip clinical researchers to translate discoveries in the laboratory to the bedside. Directed by Drs. Charles Y.C. Pak, principal investigator of the General Clinical Research Center, and Perrie Adams, associate dean for research, both at the University of Texas Southwestern Medical Center at Dallas, the symposium is intended for young physicians who wish to learn the funda­ mental techniques of clinical research, as well as for senior investigators who would like to organize a similar program. For more information, please contact: Dr. Charles Y.C. Pak, University of Texas South­ At left, Hl'aly gives Natcher the smaller oftwo birthday presents from NIH. Thebigger giftwas a framed western Medical Center at Dallas, 5323 Harry rendering ofthe NIH building named forhim. At right, Natcher shows offa new addition to his renowned Hines Boulevard, Dallas, TX 75235-8885; collection ofunusual neckwear-a Natrher Bldg. tie. phone: 214-688-2100. 0 The Record page 12 September 29, 1992

NIH Police Officers Shine In 'Olympics,' Win Five Medals

By Anne Barber

Five members of NIH's police force entered Olympics," Knowles admitted. "I would have che recent Internacional Law Enforcement trained harder and gocten the right equipment. Olympics and came away wich 1 gold, 2 silver But I'm not making any excuses. I'm looking and 2 bronze medals. Noc a bad showing for a forward to 1994 when the Olympics will be first-time entry. held in Birmingham, Ala., where I hope to The Olympic events, held during August, were make a betcer showing. spread throughout the Districc of Columbia, "I lifted 425 pounds in my squacs but depth Maryland and Virginia and included events was my problem. I have squacted deeper in from darts to "toughest cop." Participants came competitions and lifted more pounds (550) but from many countries including Australia, New noc this cime. It was a good meec though," he Zealand, The Netherlands, Hungary, Finland, said. "By the way, the champion lifted 640 Sweden, Russia, Bulgaria, China, Dubai, Hong pounds." Kong, Canada, and from all over the United Officers Miller and Blum entered the States, including Hawaii and Alaska. shooting competition-pistol, service revolver, Representing NIH were Sgt. Mark E. Knowles and high-powered rifle. They went in as (patrol section), Cpl. Bruce A. Blum (patrol unqualified masters, which meant they did not section), Cpl. Edward C. Landicho (detective), get to shoot in specific categories. Miller Cpl. Harold L. Miller (detective), and Cpl. finished 9th in rifle (out of about 50), 26th in Patrick Coajou (patrol section). semi-automatic pistol and 16th in the revolver The officers were excited about participating Landicho displays the 5 medals he won at the shoot with 250 competitors. in the Olympics and were happy to represent Olympics-} gold, 2 silver and 2 bronze. "I ranked fairly well, since this was only my NIH. "A lot of people did not know DHHS second time competing," Miller said. "So, I'm had a law enforcement group," said Miller. "In really looking forward to the 1994 Olympics." fact, we are the second largest police department individual events and one relay. Blum placed 18th in revolver, 25th in pistol, in Montgomery County." The swimming competition was scheduled for buc "not far from the bottom in rifle shooting," "We (officers) all share similar experiences," 2 days. "On the first day, when I came home he admics. "It was my first time ever in a rifle added Blum. "There were a lot of people there with two silver and two bronze medals, my competition. I realize I made mistakes. It was willing to give you pointers," Miller said. mother said to me, Thac's good. But, where's very illuminating and a Joe of fun. I would like "Like a big brotherhood," they all agreed. the gold?' That made me more determined to to do it over again." To make this point, the officers discussed go back the next day and give it my best shot. "I want to push and try more rifle events next some of the swapping of patches and hats that "Next time," he says, "I will train for che long­ time," said Miller. "I also hope to shoot in a took place among participants. Blum came distance events. I have been lifting weights and specific category. However, I don't chink we away with a Russian police banner and, in improving my endurance." did too badly because the target was at 600 exchange, gave a Russian his blue Colt hat. Knowles, weighing 235 pounds, participated yards and we only practiced at a 100-yard range "This fosters good relationships," Blum said. in power lifting in the 242-pound weight class. for a month before the meet." Landicho won all the NIH'ers' medals in the 'This was my firsc competition in 9 years," he Coajou entered the darts compecition. He swimming competition. "I chose this category," said. "My problem was that I did not get low made it to the 5th round of eliminations but he said, "because I have always been a swimmer. enough in my squats. lost in the final rounds. I began at age 6 and continued throughout "I also lacked the proper training equip­ Three of the top 15 medals in the shooting college swimming in competitions. I lift ment-power suit and proper wraps. Power events went to Hungarians; swimming was weights and participate in other sports, but I lifting is very different from lifting weighcs. dominated by Australians; and the toughest cop decided swimming was my best shot. I used to "I wish I had decided earlier to enter the was a 32-year-old from Stockholm, Sweden, do extrememly well in endurance races, but this time I only went for the shorter distances." Entering in the age group 20-29, Landicho won a gold medal in the 50-yard backstroke. He won silver medals in both the 100-yard backstroke and the 50-yard breaststroke. He also won 2 bronze medals-1 for the 100-yard individual medley and the other in the 200-yard individual medley team relay. For the gold medal, he said, "I beat out the Australian who just outtouched me in the 100- yard backstroke the day before." For the team medal, he was one of a four­ member team, where each racer participated in four categories-breaststroke, backstroke, butterfly, and freestyle. The relay team con­ sisted of officers from Maryland State Police, Representing NIH's police force at the International Law Enforcement Olympics were (from l) Cpl. Bruce Prince Georges County Sheriffs and the Secret A. Blum, Sgt. Mark E. Knowles, Cpl. Harold L. Miller, Cpl. Edward C. Landicho, and Cpl. Patrick Service. The finishing times were then averaged Coajou. out as a team. Out of four individual events and two relays, Landicho placed in four The Record page 13 September 29, I 992

who had 10 compete in eight events, all in 1 day. Landicho has his eye on this comest for Physician Assistants Celebrate Ganguly Named NHLBI Branch Chief the next Olympics. 25th Anniversary, Oct. 6 Dr. Pankaj Ganguly has been appointed chief Prior to the international comest, the NIH On Oct. 6, thousands of physician assistants of the Thrombosis and Hemostasis Branch of officerscompeted in local meets such as the around the country will celebrate the 25th NHLBI Division of Blood Diseases and Patrol Officers' Competition, sponsored anniversary of their profession. Resources. annually by the Metropolitan Washington It was on that day in 1967 that three former A nationally recognized investigator in Council of Governments. Two years ago in this medical corpsmen, who wanted to transfer to thrombosis and hemostasis, Ganguly has been event, NIH won a 3rd-place trophy in felony civilian jobs the skills they learned in the with the branch since joining NHLBI as a trafficstops; the hardware is on display in the military, graduated from the first physician health scientist administrator in 1987. He has police section, Bldg. 31C, B3 lobby. assistant (PA) educational program in the contributed to numerous division initiatives "NIH has always placed in the top 50 percent country at Duke University. related to basic and clinical studies with blood of the patrol board matches," said Miller, Today there are nearly 22,000 licensed platelets. proudly. "But that competition is more job­ practicing PA's in the United States. More than A native of Calcutta, India, Ganguly attended based, while the international competition is 50 percent of all PA's provide primary care Calcutta University, earning a B.S. with honors more individualized." including family, general medicine, internal Landicho sums up the group's feelings: "We medicine, pediatric and OB/GYN care. Nearly are all happy to make NIH known in the law a quarter of all PA's also serve as commissioned enforcement area." officers in all branches of the military. PA's Adds Miller, "We may be small, we may be take medical histories, perform physical exams, young, but never discount us. Look over your order and interpret tests, make diagnoses, shoulder, we are right behind you." D establish treatment plans, and, in many NCI-FCRDC Hosts Health Fair jurisdictions, write prescriptions. The NCI's Frederick Cancer Research and Seven PA's currently work at NIH. Three Development Center recently held its second PA's employed by NIAID provide continuity of annual Health and Safety Fair, conducted by care for inpatients, primarily with vasculitis, and the occupational health services and safety are responsible for outpatient followup visits. division of the environmental control and Four PA's in the Occupational Medical Service clinic provide care for employees with occupa­ research program. The goal was to increase health and safety awareness and provide tips to tional injuries and illnesses. A new PA will start this fall with NHLBI's bone marrow transplan­ be used at home and in the workplace. The fair was a success as more than 1,000 people tation unit. The following PA's at NIH wish their participated. colleagues a happy 25th anniversary: Sandra Dr. Raymond Gilden, director of the opera­ Dr. Pankaj Ganguly Bishop, Karen Kobayashi, Mary Stevens and tions and technical support program at NCI­ Catherine Vangellow of OMS; Jennifer Hahn, in physics and a Ph.D. in biophysics. He was a FCRDC, gave opening remarks and a formal Cheryl Talar Williams and Patricia Steele of professor of biochemistry at the University of welcome. More than 65 vendors, volunteer NIAID; and Kath n Whitfield, NHLBI. 0 Tennessee in Memphis and the University of organizations and health professionals contrib­ ry Puerto Rico in San Juan, where he also chaired uted to the event. Comprehensive health the biochemist and nutrition department. screening programs including health assessment, ry He has published more than 70 scientific hearing, blood pressure, cholesterol/triglyceride NCI Scientist's Book Is Alternate articles and served on the NIH hematology profile, diabetes, and stress assessment were Book-of-the-Month Club Selection study section. Among his awards is the 1990 provided. Vendors displayed products relevant NIH Merit Award for "dedication, commit­ to home and workplace safety such as child The TransformedCell: Unlocking the Mysteries ment, and innovation in scientific management safety devices, power and hand tool safety, and by Dr. Steven A. Rosenberg, chief of of Cancer, and program development in thrombosis and industrial safety supplies. Recycling organiza­ surgery at NCI, and John M. Barry, has been hemostasis." 0 tions distributed literature and set up visual selected as a Book-of-the-Month Club alternate displays. for September. It is published by G.P. Speakers addressed important health and Putnam's Sons. The book is also a Quality safety topics throughout the day from estrogen Paperback Book Club alternate selection. Ozone Layer Changes Discussed replacement therapy and the detection and Copies are now available in the R&W Gift management of early prostate cancer, to exercise Shop in Bldg. 31. On Oct. 8, Dr. Richard Stolarski, research and fitness and health eating, to an update on The book describes Rosenberg's efforts to scientist with the NASA Goddard Space Flight AIDS. 0 marshal a patient's own white blood cells to Center, will make a presentation to the NIH fight cancer. It traces how he and his team skin diseases interagency coordinating commit­ Ski Club To Meet developed a technique that stimulates the tee on the data that provide a fairly consistent The NIH Ski Club will meet on Thursday, body's T-cells using interleukin-2 and inserted picture of the change that has occurred in Oct. 8 at 7 p.m in Bldg. 31, Conf. Rm. 4 to foreign genes into the T-cells to help them stratospheric ozone levels. Stolarski's specialty announce details of its 1992-93 ski season and attack tumors. areas are atmospheric chemistry and strato­ take deposits for trips. Day trips include Rosenberg's purpose in writing the book was spheric ozone. Whitetail and Blue Knob; there will be a long to explain to the public how medical research is The meeting will take place from 1 :30 to weekend at Canaan Valley, W.Va., including conducted and to describe the importance of 4:30 p.m. in Bldg. 31, Conf. Rm. 7. members of the Special Love program. The big such research in a time when science "often For more information, call Sharon Nouzari­ trip of the season will be to Breckenridge, seems under siege," He details his training and Louis, 496-0801. 0 Colo., for downhill and crosscountry skiers. research and discusses the experiences of his Attend the meeting for more details. 0 patients in their battle against cancer. 0 The Record page 14 September 29, 1992

NIEHS Creates New Development Office; Johnson-Thompson Named Director Dr. Marian Johnson-Thompson, who holds a Chemistry, NCI, studying the role of protein Ph.D. degree in microbiology from kinase C in multidrug resistance with Dr. Robert Georgetown University, and for several years Glazer, whom she later joined at Georgetown has served as professor in the department of University as adjunct professor of pharmacology biology at the University of the District of in the medical school; she collaborated with him Columbia, has joined NIEHS as director of the in identifying the regulatory role of "C-fes" in newly established Office of Institutional the differentiation of myeloid leukemia cells. Development (OID). Her previous research experiences have Johnson-Thompson had previously served as included work at Howard University's Laser a member of the minority programs review Chemistry Laboratory; the space science division committee, NIGMS, where she provided of General Electric Co.; and the Lawrence leadership on the Minority Biomedical Livermore Radiation Laboratory. Research Support Program review committee. In addition, Johnson-Thompson has worked In her new position, she will serve as the focal with NASA and has served in the Office of point for establishing goals to assure diverse International Health within the Office of the populations' participation in the institute's Secretary, DHHS, analyzing health problems in research and training programs. Dr. Marian Johnson-Thompson underdeveloped countries. In addition, she will serve as principal liaison "The institute is indeed fortunate to have to minority institutions, develop programs to someone with the outstanding qualifications of increase minority populations' and institutions' program, and oversee the institute's proposed Dr. Johnson-Thompson accept this position," participation in environmental health research, graduate program in conjunction with the said NIEHS director Dr. Kenneth Olden. and coordinate overall policies related to University of North Carolina at Chapel Hill. "It is extremely important that we do all we minority health and education issues both The OID, located within the Officeof the can to introduce young minds to wonders of inside and outside NIEHS. Director, will develop policies and procedures science and to make sure that women and Johnson-Thompson will create programs for forpromoting a more aggressive minority minorities in particular are recruited." D local public schools and colleges and get recruitment program within the institute. NIEHS staff more involved in teaching. She Johnson-Thompson has worked as a molecu­ will also administer the NIEHS summer intern lar virologist in the Laboratory of Biological NIA/D's David Hoggan Retires, To Teach in China He spent countless hours in the laboratory idea behind gene therapy," says Hoggan. from the United States who wish to teach in exploring the biology and genetics of viruses. When he wasn't at the laboratory, working to China. Through the program, Hoggan, his wife Now he begins a new challenge-teaching develop an animal model for HIV or chromo­ and 31 other Americans with backgrounds English to the Chinese. some mapping endogenous murine leukemia varying from travel to chemistry will work in In July 1992, Dr. M. David Hoggan retired as viruses, Hoggan foundtime to pursue scuba China this year. a senior scientist in the Laboratory of Molecular diving, skiing and biking, with camera close at Hoggan received his B.S. degree in 1952 and Microbiology, NIAID, after 29 years of service hand. his M.S. degree in 1953, both in bacteriology, to NIH and the PHS. "He uses a camera much like an electron from the University of Utah. After completing "After spending 8 to 14 hours in the lab every microscope," says colleague Dr. Roy Repaske, his Sc.D. degree in microbiology at Johns day, it's hard to make the break," says Hoggan. "always looking for that perfect photograph." Hopkins University in 1959, he joined the U.S. "I am very fortunate to have worked with such Hoggan conducted much of his early research Army's Bacteriology, Immunology and Infec­ great colleagues at NIH." using an electron microscope. tious Disease Branch in Washington, D.C. He "Dr. Hoggan is an eminent scientist whose In August, Hoggan began another venture. became a PHS commissioned officer in 1963 work has furthered research on a number of Through the David M. Kennedy Center for and began working in the Laboratory of Viral different viruses," says Dr. Malcolm Martin, International Studies at Brigham Young Diseases, NIAID. In 1984, he moved to the chief of the Laboratory of Molecular Microbiol­ University (BYU), Hoggan and his wife have Laboratory of Molecular Microbiology, becom­ ogy. taken a !-year teaching assignment at the ing a senior scientist in 1990. One of Hoggan's most important contribu­ Zhenjiang Medical University in Hang Zhou, During his career, Hoggan received the Medal tions, Martin says, occurred in 1975 when he Province of Zhejiang, People's Republic of for Meritorious Service from the Armed Forces demonstrated that a parvovirus, the adeno­ China. Institute of Pathology and two PHS Commenda­ associated virus, was able to integrate copies of The Haggans are members of the Church of tion Service Medals. He is a member of the its DNA genome into mammalian cells. Jesus Christ of Latter-day Saints, which runs American Society forMicrobiologists, the Parvoviruses, capable of causing serious disease the Kennedy Center. American Association of Immunologists and the in certain animals, also can infect people, but At Zhenjiang, Hoggan teaches English to Electron Microscopy Society of America.-Mary thus far are not known to cause disease in Chinese medical students and college students Jane Walker 0 humans. preparing to study medicine. His wife also This finding has opened doors to the develop­ teaches English at the university. Research Subjects Needed ment and use of parvoviruses as vectors in gene "We knew we wanted to go back to China; The NICHD is seeking infants for a longitudi­ therapy. Viruses, acting as vectors or carriers, we've been there before and love the people," nal study of cognitive and social development. provide a way to introduce foreign genes into he says. Infants must be 2 months old between Oct. 1, cells. The Kennedy Center, BYU's focal point for 1992, and Jan. 1, 1993. For more information, "If you could replace the sick gene or superim­ study and research concerning international call Deborah Clay, 496-6832, and ask for pose another one using a vector like a affairs, acts as an employment agency, supply­ information on the infant study.□ parvovirus-well you know that's the whole ing Chinese agencies with names of people The Record page 15 September 29, 1992

TRAINING TIPS Training Center Mourns Roy Chisholm The NIH Training Center, Division of Leroy C. Chisholm, Jr., an employee graduated from Frederick Douglass High Personnel Management, offers the following development specialise with the NIH Training School in Upper Marlboro, Md., and lacer "hands-on" IBM and Macintosh computer Center, Division of Personnel Management, served in the U.S. Navy, from which he was courses: died suddenly on Thursday, Sepe. 3, at age 46. honorably discharged in 1973. He was a Better known as Roy, he began his career at graduate of Howard University, earning a Personal Computing Training 496-6211 NIH with the National Cancer Institute in bachelor of science degree and a master's Course Titles Starting Dates 1972. Since 1974 he has been with the NIH degree in guidance and counseling. Lacer he Welcome co Macintosh 11/9 Training Center, where he assumed responsi­ earned another master's degree in adulc Advanced Macintosh Techniques 11/18 bility for a number of programs including education from the University of the District MacWrite 11/30 Upward Mobility College, career planning and of Columbia and was enrolled in doctoral Intro co WordPerfect 2.0 (Mac) 11/17 development, and supervisory and manage­ study at Grambling University. Excel-Level I 11/16 ment development. In 1992 he received an His professional affiliations included the Excel-Level 2 I 1/15 3Com PC Network-Level I 11/16 NIH Merit Award. American Society for Training and Develop­ Intro to Personal Computing Chisholm was known for his hardworking ment, the American Society for Personnel forNew Users I 0/30, I 1/20 professionalism and his warm and caring Administration, and the National Association Disaster Recovery and Data Retrieval manner both at NIH and throughout the of Adule Educators. Chisholm was in demand for the PC I 1/13 Washington area. His attention co detail, as a speaker on career change and was also Intro co Windows 11/'), 11/23 follow through, and personal commitment employed part-time as a real estate associate. WordPerfect for Windows 11/10, 11/17 endeared him to clients and colleagues alike, Several hundred people including relatives, WordPerfect 5.1 - Advanced Topics I 1/16 Intro to DOS 5.0 11/2 many of whom credit him for their career friends and coworkers gathered on Sept. 9 at Intro to WordPerfect 5.1 I 1/3 successes. Sc. Paul United Methodist Church in Oxon Intro to Paradox 10/27 A native of Washington, D.C., Chisholm Hill, Md., co bid him farewell. Advanced Paradox 11/24 Intro to dBASE IV 10/28 Intro to dBASE III+ 11/4 NCI Retired Scientist Delta Uphoff Dies IMPACT System for Personnel Staff 10/15, I 1/3 Delea Emma Uphoff, 70, an NCI scientist Uphoffwas born in Brooklyn, graduated IMPACT System for for more than 40 years, died Aug. 24 of lung from Russell Sage College in 1944 and Administrative Staff I 0/2'>, I 1/23 cancer. received her M.S. degree from the University IMPACT System for She started working at NCI in 1949 as a Rochester in 1947. In 1982, Uphoffs alma Professional Staff I 0/2'>, I 1/23 of Intro to CRISP 10/30 research biologist in the Laboratory of macer, Russell Sage College, awarded her with Biophysics with Egon Lorenz on radiation an honorary doctorate of science. Uphoff Theatre Group Presents Kern Gala biology. Uphoff did pioneering work on the officially retired from DCBDC in December The NIH R&W Theatre Group will present restoration of mice after lethal doses of 1989, and then became a guest researcher in The Melody Lingers On, on Nov. 6, 7, 13, 14, radiation. Uphoff and Lorenz were the first co January 1990. 20 and 21 at 8 p.m., and Nov. 8 and 15 at 3 demonstrate chat bone marrow cells could Uphoffslacer research interests focused p.m. in Masur Auditorium, Bldg. 10. protect lethally irradiated mice from certain primarily on the immunogenetics of bone The production is a journey through Jerome death. Uphoffdetermined the number of marrow transplantation. She noticed chat Kern's vision of a musical revue of his finest bone marrow cells chat were required for when bone marrow cells from a parental strain songs, including "Why Was I Born?", "Smoke protection. This work foreshadowed a whole were transplanted into appropriately irradiated Gets In Your Eyes," "She Didn't Say Yes," 'The field of research on the mammalian hemato­ hybrid offspring, a lethal syndrome was Lase Time I Saw Paris," and many ochers, plus poiecic seem cells, which are found in greatest thought co be a result of the graft rejecting the selections from Showboat. Larry Salkin and abundance in the bone marrow. Working host. Her work provided further early Gary Daum are directing a talented cast of with Drosophila, Uphoff and associates also evidence of graft versus hose tissue interac­ actors, singers and dancers. discovered there was no threshold for tions. Uphoff maintained one of the most Ticket prices are $7 for adults, $5 for seniors, radiation's ability co rearrange chromosomes or strictly controlled mouse colonies on the and $3 for children 12 and under. damage genes. Even the lowest doses can campus. She also investigated the long-term The Theatre Group is an ensemble of NIH cause changes. genetic effects of ova transplantation. employees and community members who each year present a musical revue and a dramatic production for the benefit of the NIH Patient Water/Steam Pipes To Be Laid Between Buildings 13, 5 and Center Drive Emergency Fund. For information and tickets, call Brenda Merson, 496-4835, or (301) 253- This fall, the Division of Engineering Services meet future campus needs. 3511. 0 will begin construction of an underground Construction is expected co cake approxi­ utility tunnel for chilled water and steam piping mately a year and a half and will scare with an Blood Donations Needed at NIH between Bldgs. 13, 5 and Center Drive. open cut excavation through parking lot 13C, Now chat summer has drawn co a close and This construction is pare of the Infrastructure from west to east. Small portions of the lot (30- most employees are back co work, the NIH Modernization and Improvement Program co 70 parking spaces) will be closed at any time, Blood Donor Center reminds NIH'ers chat it replace aging campus infrastructure systems chat depending on construction phasing. still needs blood. The center did well during are becoming more inefficient. DES regrets any inconvenience that may be the prime vacation months in maintaining an By replacing the chilled water and steam caused by these improvements. 0 adequate supply of blood for patient care. Bue lines, an improved, more reliable heating and it reminds employees co put blood donation on cooling service will be provided co current their "co do" lists for autumn. To make an campus buildings and will permit DES co better appointment, call 496-1048. 0 The Record page 16

September 29, 1992

Dogs, Frogs Hog the Show

NilI's 2-Day Open House Draws Thousands OctoberLow CostIs Breast Mammography Cancer Awareness Month N Screening Available at NIH early 4,000 visitors got a taste of NIH D two weekends ago when the agency ue to its popularity and importance, low­ cost mammography screening will be presented its first open house in 5 years. Of the offered twice each year, in the fall and spring. more than 40 exhibits gathered in a humongous This service is coordinated through the Office tent adjacent to the Stone House, the animal of Disease Prevention of the Office of the presentations were the most popular. Director. The cost of $60 is reimbursable "The two biggest hits were the frogs and the through any health insurance company in the dogs," said Thomas Flavin, NIH special project State of Maryland that also pays for breast officer, whose office coordinated the event. The cancer treatment. A mammogram is a low dose koi-koi frog exhibit allowed visitors to examine x-ray that can detect breast cancer at its earliest, poisonous amphibians under study at NIH; the most treatable stage-up to 3 years before other methods. The mobile screening program will be provided by the University of Maryland Cancer Center, whose technique and equipment have Vernon Williams, a ninth grader at Paul Junior been accredited by the American College of High School in the District, got a kick out ofthe Radiology. Female radiology technologists will "Path ofPain" exhibit during NIH'sfirst open perform clinical breast exams and conduct the house in 5 years. mammograms. This combination achieves maximum detection rates. The procedure itself may cause brief, slight discomfort, but is not to get a feel for the research atmosphere. Many painful. The results will be read by a board­ seemed surprised, he continued, that NIH is so certified radiologist and sent to each woman much more than laboratories and microscopes. and her physician of choice. The NCI recom­ Another offering that drew large crowds was mends that all women get a mammogram every the Healing Garden, a collection of plants being 2 years between ages of 40-49 and annually studied for their therapeutic value. In addition thereafter. To be eligible to use this service women must: eBe asymptomatic-experiencing no current breasteNot problems (not have a lump, or nipple Students from Paul junior High and Flint Hill discharge and no history of breast cancer); School were among the more than 2,000 visitors eNot have had a mammogram within the last from 25 schools to gather literature and other 12eNot months; materials from 40 exhibits and institute booths have breast implants; during the finalday ofopen house. be pregnant or nursing. The appointment will take approximately 20 minutes. Appointments may be made by dogs-Nicky, a narcotics detector, and Turbo, a calling the University of Maryland Cancer bomb specialist-performed under the direction Center, 1-800-787-0506. Payment options of NIH's police department. include a personal check, money order, Visa or According to Flavin, many of the visiting Mastercard. Space is limited and requests will families brought their young aspiring scientists be handled on a first-come, first-served basis. For more information call OMS, 496-4411, Dates and Locations Officer Pat Pozar and bomb-detector dog Turbo and ask forthe triage nurse. (1) and Officer Gerald Watson and narcotics­ detector dog Nicky presented one ofthe most Thursday, Oct. 15 All Day Bldg. 31 popular demonstrations at NIH's open house held Friday, Oct. 16 All Day Bldg. 10 in an enormous tent on parking lot 16. Monday, Oct. 19 All Day Bldg. 10 Tuesday, Oct. 20 8:30 a.m.-12:30 p.m. Westwood NormalThursday, Oct.Volunteers 22 1-5 p.m. Needed EPN&S

to standing displays under the tent, bus tours of the campus grounds were led by NIH employ­ The voice and speech section, NIDCD, needs ees. Outside the tent, the NIH fire department healthy, nonmedicated, males and females ages gave hands-on tours of a fire engine and 20-60 to participate in a PET scan study to demonstrated safety equipment and procedures. determine which areas of the brain are involved On Monday, Sept. 14, the open house in speech production. Subjects will be seen continued for local school children. About three times; a neurological evaluation and speech task training prior to the scan for 1 '12 NCNR's Suzie Watson (l) staffed her center's 2,000 students from 25 schools, mainly middle hours. Subjects will be paid a total of $300. If booth in the big open house tent that stood through and junior high schools, were ushered through interested, call Dr. Allen Braun, 496-7492, or more than 4,000 visitors over 2 days. the "big top," where they collected hats, posters, U.S. GOVERNMENT PRINTING OFFICE 1992-281-825/!,0027 stickers and bags emblazoned with NIH Geralyn Schulz, 496-9365. D programs and services.-Carla Garnett D