The Lymphatic System and the Cardiovascular System Are Closely Related Structures That Are Joined by a Capillary System
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
29 Assessing the Cardiovascular and Lymphatic Systems
29 Assessing the Cardiovascular and Lymphatic Systems LEARNING OUTCOMES 1. Describe the anatomy, physiology, and functions of the 5. Explain techniques used to assess cardiovascular and cardiovascular and lymphatic systems. lymphatic structure and function. 2. Describe normal variations in cardiovascular assessment 6. Identify manifestations of impaired cardiovascular structure findings for the older adult. and functions. 3. Give examples of genetic disorders of the cardiovascular system. 4. Identify specific topics for consideration during a health history assessment interview of the patient with cardiovascu- lar or lymphatic disorders. CLINICAL COMPETENCIES 1. Complete a health history for patients having alterations in 3. Assess an ECG strip and identify normal rhythm and cardiac the structure and functions of the cardiovascular or lymphatic events and abnormal cardiac rhythm. systems. 4. Monitor the results of diagnostic tests and communicate 2. Conduct and document a physical assessment of cardiovas- abnormal findings within the interprofessional team. cular and lymphatic status. MAJOR CHAPTER CONCEPTS • Correct structure and function of the cardiovascular and • Manifestations of dysfunction, injury, and disorders affecting lymphatic systems are vital to the transport of oxygen and the cardiovascular and lymphatic systems may be detected carbon dioxide throughout the body and for the return of during a general health assessment as well as during focused excess tissue fluids back to the bloodstream. cardiovascular and lymphatic system -
Lymphatic Dysregulation in Patients with Heart Failure JACC Review Topic of the Week
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY VOL. 78, NO. 1, 2021 ª 2021 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION PUBLISHED BY ELSEVIER THE PRESENT AND FUTURE JACC REVIEW TOPIC OF THE WEEK Lymphatic Dysregulation in Patients With Heart Failure JACC Review Topic of the Week a,b c d e Marat Fudim, MD, MHS, Husam M. Salah, MD, Janarthanan Sathananthan, MBCHB, MPH, Mathieu Bernier, MD, f g e,h i Waleska Pabon-Ramos, MD, MPH, Robert S. Schwartz, MD, Josep Rodés-Cabau, MD, PHD, François Côté, MD, j d a,b Abubaker Khalifa, MD, Sean A. Virani, MD, MSC, MPH, Manesh R. Patel, MD ABSTRACT The lymphatic system is an integral part of the circulatory system and plays an important role in the volume homeostasis of the human body. The complex anatomy and physiology paired with a lack of simple diagnostic tools to study the lymphatic system have led to an underappreciation of the contribution of the lymphatic system to acute and chronic heart failure (HF). Herein, we discuss the physiological role of the lymphatic system in volume management and the evidence demonstrating the dysregulation of the lymphatic system in HF. Further, we discuss the opportunity to target the lymphatic system in the management of HF and different potential approaches to accessing the lymphatic system. (J Am Coll Cardiol 2021;78:66–76) © 2021 by the American College of Cardiology Foundation. he circulatory system consists of the cardio- lead to interstitial edema with clinical manifestations T vascular system and the lymphatic system. such as extremity and tissue edema, including pulmo- The cardiovascular system is a closed, high- nary edema. -
Cancer and Lymphatics: Part I
Cancer And Lymphatics: Part I Jassin M. Jouria, MD Dr. Jassin M. Jouria is a medical doctor, professor of academic medicine, and medical author. He graduated from Ross University School of Medicine and has completed his clinical clerkship training in various teaching hospitals throughout New York, including King’s County Hospital Center and Brookdale Medical Center, among others. Dr. Jouria has passed all USMLE medical board exams, and has served as a test prep tutor and instructor for Kaplan. He has developed several medical courses and curricula for a variety of educational institutions. Dr. Jouria has also served on multiple levels in the academic field including faculty member and Department Chair. Dr. Jouria continues to serves as a Subject Matter Expert for several continuing education organizations covering multiple basic medical sciences. He has also developed several continuing medical education courses covering various topics in clinical medicine. Recently, Dr. Jouria has been contracted by the University of Miami/Jackson Memorial Hospital’s Department of Surgery to develop an e-module training series for trauma patient management. Dr. Jouria is currently authoring an academic textbook on Human Anatomy & Physiology. ABSTRACT In the human body, cells receive nutrition and oxygen from lymph, a fluid that is recirculated through the body via an extensive network of vessels. Upon arriving at one of many nodes found within the body, the lymph is filtered to discern healthy cells from those carrying disease or infection. However, cancer can either develop in the lymph nodes around the body, or it can travel there via the lymphatic vessel network. -
Structure, Function, and Molecular Control of the Skin Lymphatic System
CORE Metadata, citation and similar papers at core.ac.uk Provided by Elsevier - Publisher Connector Structure, Function, and Molecular Control of the Skin Lymphatic System Mihaela Skobe and Michael Detmar Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, U.S.A. The mechanisms of angiogenesis have been studied phatic vasculature and the differences between blood extensively over the past years. The focus, however, and lymphatic vessels. Special attention has been has been almost exclusively on blood vessels, whereas given to the methods employed in research of the little effort has been directed toward understanding lymphatic system. Finally, we describe molecular lymphangiogenesis and the role of lymphatic vessels mechanisms involved in the regulation of lymphan- in physiology and pathology. The lymphatic system, giogenesis. Vascular endothelial growth factor and acting in concert with the blood vascular system, is vascular endothelial growth factor-C, expressed by of fundamental importance in maintaining tissue distinct skin cell populations, play an important role homeostasis, and disorders of the lymphatic system in the molecular control of skin angiogenesis and are common, often resulting in chronic, disabling lymphangiogenesis. Key words: lymphatic vessels/lymph- conditions. This overview summarizes the most angiogenesis/skin/VEGF-C. Journal of Investigative important aspects of the structure and function of Dermatology Symposium Proceedings 5:14±19, 2000 the lymphatic system with emphasis on the skin lym- ur understanding of the biology of the lymphatic covered'' (Bartels, 1909). The ancient Greeks observed structures system is well illustrated by the word lymphatic containing colorless ¯uid (Hippocrates spoke of ``white blood'') but itself; the derivation of the latin word lymphaticus their function was not understood and the signi®cance of the signi®es ``distracted and confused'' (Witte et al, ®nding was not recognized. -
Lymphatic Tissue Engineering and Regeneration Laura Alderfer1, Alicia Wei1 and Donny Hanjaya-Putra1,2,3,4,5,6*
Alderfer et al. Journal of Biological Engineering (2018) 12:32 https://doi.org/10.1186/s13036-018-0122-7 REVIEW Open Access Lymphatic Tissue Engineering and Regeneration Laura Alderfer1, Alicia Wei1 and Donny Hanjaya-Putra1,2,3,4,5,6* Abstract The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the molecular mechanisms and underlying disease pathology largely remain to be understood which has hindered advancements in therapeutic options for lymphatic disorders. Dysfunction of the lymphatic system is associated with a wide range of disease phenotypes and has also been speculated as a route to rescue healthy phenotypes in areas including cardiovascular disease, metabolic syndrome, and neurological conditions. This review will discuss lymphatic system functions and structure, cell sources for regenerating lymphatic vessels, current approaches for engineering lymphatic vessels, and specific therapeutic areas that would benefit from advances in lymphatic tissue engineering and regeneration. Keywords: Lymphangiogenesis, Tissue Engineering, Disease Modeling, Wound Healing, Lymphedema, Stem Cells, Biomaterials, Interstitial Fluid, Regeneration I. Introduction to the Lymphatic System and its role Interstitial fluid (IF) is a plasma filtrate that is generated Function by transcapillary filtration and is governed by Starling The lymphatic system is nearly ubiquitous in the human forces, the net difference between hydrostatic and body, present in all tissues except the epidermis, cartil- osmotic pressures, at the microcirculatory level [9]. In age, eye lens, cornea, retina, and bone marrow [1, 2]. order to maintain fluid homeostasis, lymph formation in The main functions of the lymphatic system include the initial lymphatic vessels must be balanced by the net fluid homeostasis and interstitial fluid drainage, immune flux of plasma being filtered out [4]. -
Anatomy and Physiology in Relation to Compression of the Upper Limb and Thorax
Clinical REVIEW anatomy and physiology in relation to compression of the upper limb and thorax Colin Carati, Bren Gannon, Neil Piller An understanding of arterial, venous and lymphatic flow in the upper body in normal limbs and those at risk of, or with lymphoedema will greatly improve patient outcomes. However, there is much we do not know in this area, including the effects of compression upon lymphatic flow and drainage. Imaging and measuring capabilities are improving in this respect, but are often expensive and time-consuming. This, coupled with the unknown effects of individual, diurnal and seasonal variances on compression efficacy, means that future research should focus upon ways to monitor the pressure delivered by a garment, and its effects upon the fluids we are trying to control. More is known about the possible This paper will describe the vascular Key words effects of compression on the anatomy of the upper limb and axilla, pathophysiology of lymphoedema when and will outline current understanding of Anatomy used on the lower limbs (Partsch and normal and abnormal lymph drainage. It Physiology Junger, 2006). While some of these will also explain the mechanism of action Lymphatics principles can be applied to guide the use of compression garments and will detail Compression of compression on the upper body, it is the effects of compression on fluid important that the practitioner is movement. knowledgeable about the anatomy and physiology of the upper limb, axilla and Vascular drainage of the upper limb thorax, and of the anatomical and vascular It is helpful to have an understanding of Little evidence exists to support the differences that exist between the upper the vascular drainage of the upper limb, use of compression garments in the and lower limb, so that the effects of these since the lymphatic drainage follows a treatment of lymphoedema, particularly differences can be considered when using similar course (Figure 1). -
Lymph and Lymphatic Vessels
Cardiovascular System LYMPH AND LYMPHATIC VESSELS Venous system Arterial system Large veins Heart (capacitance vessels) Elastic arteries Large (conducting lymphatic vessels) vessels Lymph node Muscular arteries (distributing Lymphatic vessels) system Small veins (capacitance Arteriovenous vessels) anastomosis Lymphatic Sinusoid capillary Arterioles (resistance vessels) Postcapillary Terminal arteriole venule Metarteriole Thoroughfare Capillaries Precapillary sphincter channel (exchange vessels) Copyright © 2010 Pearson Education, Inc. Figure 19.2 Regional Internal jugular vein lymph nodes: Cervical nodes Entrance of right lymphatic duct into vein Entrance of thoracic duct into vein Axillary nodes Thoracic duct Cisterna chyli Aorta Inguinal nodes Lymphatic collecting vessels Drained by the right lymphatic duct Drained by the thoracic duct (a) General distribution of lymphatic collecting vessels and regional lymph nodes. Figure 20.2a Lymphatic System Outflow of fluid slightly exceeds return Consists of three parts 1. A network of lymphatic vessels carrying lymph 1. Transports fluid back to CV system 2. Lymph nodes 1. Filter the fluid within the vessels 3. Lymphoid organs 1. Participate in disease prevention Lymphatic System Functions 1. Returns interstitial fluid and leaked plasma proteins back to the blood 2. Disease surveillance 3. Lipid transport from intestine via lacteals Venous system Arterial system Heart Lymphatic system: Lymph duct Lymph trunk Lymph node Lymphatic collecting vessels, with valves Tissue fluid Blood Lymphatic capillaries Tissue cell capillary Blood Lymphatic capillaries capillaries (a) Structural relationship between a capillary bed of the blood vascular system and lymphatic capillaries. Filaments anchored to connective tissue Endothelial cell Flaplike minivalve Fibroblast in loose connective tissue (b) Lymphatic capillaries are blind-ended tubes in which adjacent endothelial cells overlap each other, forming flaplike minivalves. -
Functions of Lymphatic System
Lymphatic system The lymphatic system contains three parts, a network of lymphatic vessels, a fluid inside of the vessels called lymph, and lymph nodes that cleanse the lymph while it passes through. Functions of Lymphatic system: 1. Draining excess interstitial fluid-It is responsible for the removal of interstitial fluid from tissues 2. Transporting dietary lipids-It absorbs and transports fatty acids and fats as chyle from the digestive system 3. Carrying out immune response- It transports white blood cells to and from the lymph nodes into the bones. The lymph transports antigen-presenting cells, such as dendritic cells, to the lymph nodes where an immune response is stimulated. 4. The lymphatic system returns fluids that have leaked from the blood (vascular system) back to the blood. Without it, our cardiovascular and immune systems would begin to shut down. FLOW OF LYMPH Lymphatic Capillaries Lymphatic capillaries merge together into larger lymphatic vessels to carry lymph through the body. The structure of lymphatic vessels closely resembles that of veins: they both have thin walls and carrying fluids under low pressure. Lymph is transported through lymphatic vessels by the skeletal muscle pump— contractions of skeletal muscles constrict the vessels to push the fluid forward. Check valves prevent the fluid from flowing back toward the lymphatic capillaries. The sequence of fluid flow is blood capillaries (blood) interstitial spaces (interstitial fluid) lymphatic capillaries (lymph) lymphatic vessels (lymph) lymphatic ducts (lymph) junction of the internal jugular and subclavian veins (blood). The interstitial fluid picked up by lymphatic capillaries is known as lymph. Lymph very closely resembles the plasma found in the veins: it is a mixture of about 90% water and 10% solutes such as proteins, cellular waste products, dissolved gases, and hormones. -
Lymphatic System Urls
Lymphatic System URLs Human Anatomy & Physiology 16 http://www.howstuffworks.com/immune-system.htm http://www.thebody.com/step/immune.html http://www.emc.maricopa.edu/faculty/farabee/BIOBK/ BioBookIMMUN.html & http://www.cayuga-cc.edu/about/facultypages/greer/ r http://www.acm.uiuc.edu/sigbio/project/updated- lymphatic/lymph1.html http://www.pblsh.com/Healthworks/lymphart.html Karen Webb Smith Unit Fou Introduction A. The lymphatic system is closely associated with the cardiovascular system and is comprised of a network of vessels that circulate body fluids. B. Lymphatic vessels transport excess fluid away from interstitial spaces between cells in most tissues & return it to the bloodstream. C. Lymphatic vessels called lacteals (located in the in the lining of the smallsmall intestine) absorb fats resulting from digestion, & then transport fats to the circulatory system. D. The organs of the lymphatic system help defend Lymphatic vessels against disease. transporting fluid from interstitial spaces to the bloodstream Lymphatic Pathways A. Lymphatic pathways start as lymphatic capillaries that merge to form larger vessels that empty into the circulatory system. (This is key to understanding this chapter.) B. Lymphatic Capillaries *are microscopic, close-ended tubes that extend into interstitial spaces forming networks that parallel the networks of the blood capillaries *walls consist of single layer squamous epithelial cells which enables interstitial fluid to enter the lymphatic capillaries *lymph – the fluid inside a lymph capillary C. Lymphatic Vessels *walls of lymphatic vessels are thinner than walls of veins * have semilunar valves to prevent backflow of lymph *lymph nodes – specialized lymph organs that are composed of a mass of lymphoid tissue located along the course of a lymphatic vessel D. -
Circulatory and Lymphatic System Infections 1105
Chapter 25 | Circulatory and Lymphatic System Infections 1105 Chapter 25 Circulatory and Lymphatic System Infections Figure 25.1 Yellow fever is a viral hemorrhagic disease that can cause liver damage, resulting in jaundice (left) as well as serious and sometimes fatal complications. The virus that causes yellow fever is transmitted through the bite of a biological vector, the Aedes aegypti mosquito (right). (credit left: modification of work by Centers for Disease Control and Prevention; credit right: modification of work by James Gathany, Centers for Disease Control and Prevention) Chapter Outline 25.1 Anatomy of the Circulatory and Lymphatic Systems 25.2 Bacterial Infections of the Circulatory and Lymphatic Systems 25.3 Viral Infections of the Circulatory and Lymphatic Systems 25.4 Parasitic Infections of the Circulatory and Lymphatic Systems Introduction Yellow fever was once common in the southeastern US, with annual outbreaks of more than 25,000 infections in New Orleans in the mid-1800s.[1] In the early 20th century, efforts to eradicate the virus that causes yellow fever were successful thanks to vaccination programs and effective control (mainly through the insecticide dichlorodiphenyltrichloroethane [DDT]) of Aedes aegypti, the mosquito that serves as a vector. Today, the virus has been largely eradicated in North America. Elsewhere, efforts to contain yellow fever have been less successful. Despite mass vaccination campaigns in some regions, the risk for yellow fever epidemics is rising in dense urban cities in Africa and South America.[2] In an increasingly globalized society, yellow fever could easily make a comeback in North America, where A. aegypti is still present. -
Human and Nonhuman Primate Meninges Harbor Lymphatic Vessels
SHORT REPORT Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI Martina Absinta1†, Seung-Kwon Ha1†, Govind Nair1, Pascal Sati1, Nicholas J Luciano1, Maryknoll Palisoc2, Antoine Louveau3, Kareem A Zaghloul4, Stefania Pittaluga2, Jonathan Kipnis3, Daniel S Reich1* 1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States; 2Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, United States; 3Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, United States; 4Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States Abstract Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents. In primates, *For correspondence: meningeal -
New Brain Lymphatic Vessels Drain Old Concepts
EBioMedicine 2 (2015) 776–777 Contents lists available at ScienceDirect EBioMedicine journal homepage: www.ebiomedicine.com In Focus New Brain Lymphatic Vessels Drain Old Concepts Lasse Dissing-Olesen, Soyon Hong, Beth Stevens⁎ Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA The brain has traditionally been considered an immune privileged vessels above the dcLN completely abolished drainage of dye to these organ, in part due to the lack of evidence for lymphatic vasculature lymph nodes and additionally, increased the diameter of the meningeal (Galea et al., 2007). Two centuries ago, the existence of lymphatic ves- lymphatic vessels, indicating that these vessels drain to the dcLN. The sels on the surface of the human brain was proposed but it has since Alitalo lab further demonstrated that dye injected into the brain paren- been widely dismissed (Lukic et al., 2003). Therefore, while T cells chyma was absorbed by lymphatic vessels and preferentially drained leave all other organs via the lymphatic system to reach nearby lymph into the ipsilateral dcLN from the base of the brain. Surprisingly, Kipnis' nodes, the prevailing view has been that infiltrated T cells exit the lab excluded the best-known route of drainage into the dcLN, via the brain via venous blood circulation, circumventing the lymph nodes nasal cavity's cribriform plate and the nasal mucosa (Kida et al., 1995), (Ransohoff and Engelhardt, 2012). The recent evidence for the existence as they failed