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US 20190281835A1 ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0281835 A1 SAELINGER et al. (43 ) Pub . Date : Sep . 19 , 2019 ( 54 ) METHOD AND PESTICIDAL MIXTURES Publication Classification FOR CONTROLLING PENTATOMIDAE (51 ) Int. Cl. PESTS AOIN 65 /00 ( 2006 .01 ) AOIN 47 / 20 ( 2006 . 01) ( 71 ) Applicant : BASF SE , Ludwigshafen (DE ) AOIN 43 /22 ( 2006 .01 ) ( 72 ) Inventors : Daniel SAELINGER , Ludwigshafen AOIN 43 /56 ( 2006 .01 ) (DE ) ; Joachim DICKHAUT, AOIN 43 / 90 (2006 .01 ) Heidelberg (DE ) : Karsten KOERBER . (52 ) U . S . Cl. Eppelheim (DE ) ; Wolfgang VON CPC .. .. .. A01N 65 / 00 (2013 . 01 ) ; AOIN 47 /20 DEYN , Neustadt (DE ) ; Raffael ( 2013 . 01 ) ; A01N 43/ 22 ( 2013. 01 ) ; Y024 KOLLER , Zuerich (CH ) ; Arun 50 /322 ( 2018 .01 ) ; A01N 43 /90 (2013 .01 ) ; NARINE , Mannheim (DE ) ; Jean - Yves YO2A 50 /354 ( 2018 . 01 ) ; YO2A 50 / 352 WACH , Zuerich ( CH ) ; Jochen DIETZ , (2018 . 01 ) ; A01N 43 / 56 ( 2013 . 01 ) Karlsruhe (DE ) ; Diana LONDONO , Apex , NC (US ) (57 ) ABSTRACT (21 ) Appl . No .: 16 /422 , 090 The invention relates to a method for controlling pests from (22 ) Filed : May 24 , 2019 the family of Pentatonidae , comprising the step of contact ing the pests , their food supply , habitat or breeding grounds Related U . S . Application Data with a pesticidal mixture comprising as active compound I at least one component of the ginkgo tree I , selected from the (63 ) Continuation of application No . 15 /519 , 278 , filed on group consisting of bilobalide, ginkgolide A , ginkgolide B , Apr. 14 , 2017 , now Pat. No. 10 ,334 ,859 , filed as ginkgolide C , ginkgolide J and ginkgolide M , and at least application No . PCT/ EP2015 /074067 on Oct . 16 , one pesticidally active compound II and / or at least one 2015 . fungicidally active compound III , as defined in the descrip (60 ) Provisional application No . 62/ 064, 493 , filed on Oct . tion , in a synergistically effective amount. 16 , 2014 . The invention further relates to certain of these mixtures . US 2019 / 0281835 A1 Sep . 19 , 2019 METHOD AND PESTICIDAL MIXTURES [0011 ] There also exists the need for pest control agents FOR CONTROLLING PENTATOMIDAE that combine knock -down activity with prolonged control, PESTS that is , fast action with long lasting action . [0012 ] Another difficulty in relation to the use of pesti CROSS -REFERENCE TO RELATED cides is that the repeated and exclusive application of an APPLICATIONS individual pesticidal compound leads in many cases to a rapid selection of pests which have developed natural or [0001 ] This application is a continuation of U . S . applica adapted resistance against the active compound in question . tion Ser . No . 15 / 519 , 278 , filed Apr. 14 , 2017 , the entire contents of which are hereby incorporated herein by refer Therefore there is a need for pest control agents that help ence . U . S . application Ser. No. 15 /519 , 278 is a National prevent or overcome resistance . Stage application of International Application No . PCT/ [ 0013 ] It was therefore an object of the present invention EP2015 /074067 , filed Oct . 16 , 2015 , which claims the to provide pesticidal mixtures for the control of Pentatomi benefit of U . S . Provisional Application No .62 / 064 , 493, filed dae pests which solve at least one of the discussed problems Oct . 16 , 2014 , the entire contents of both of which are such as reducing the dosage rate , enhancing the spectrum of hereby incorporated herein by reference . activity or combining knock - down activity with prolonged [0002 ] The invention relates to a method for controlling control or as to resistance management. Pentatomidae pests , particularly in soybean crops, by apply [ 0014 ] It has been found that this object is in part or in ing a pesticidalmixture comprising insecticidal components whole achieved by applying the combination of active of the ginkgo tree . The invention further relates to pesticidal components of the ginkgo tree and further pesticides defined mixtures comprising insecticidal components of the ginkgo below . tree , their production and uses thereof. [0015 ] Further it has been found that mixtures of the [0003 ] Stink bugs (order of Hemiptera, family of Pentato specific active components of the ginkgo tree and further midae ) are animal pests and true bugs . They are probably insecticidal and /or fungicidal compounds show synergistic one of the most common pest problems in soybean (Stewart effect in the contest of various pests and fungi. et al. , Soybean Insects — Stink bugs , University of Tennessee [0016 ] Accordingly , in one aspect of the invention there is Institute of Agriculture, W200 09 - 0098 ) . provided a method for controlling pests from the family of [ 0004 ] Stink bugs feed on over 52 plants , including native Pentatonidae, comprising the step of contacting the pests , and ornamental trees, shrubs, vines , weeds , and many cul their food supply , habitat or breeding grounds with a pesti tivated crops such as corn and cotton , as well as numerous cidal mixture comprising as active compounds uncultivated plants, and their preferred hosts are nearly all [0017 ] 1 ) at least one compound I , which is a component wild plants . They build up on these hosts and move to of the ginkgo tree selected from the group consisting of soybeans late in the season as their preferred foods mature . bilobalide , ginkgolide A , ginkgolide B , ginkgolide C , [0005 ] Stink bugs may feed on many parts of the plant, ginkgolide J and ginkgolide M , however they typically target developing seed including the [0018 ] and pods , meaning that injury to soybean seed is the primary [0019 ] at least one pesticidally active compound II problem associated with stink bug infestations . selected from groups M and / or L consisting of [0006 ] Control of stinkbugs in soybean is often vital to [ 0020 ] II - M . 1 Acetylcholine esterase inhibitors : prevent significant economic damage . [0021 ] II - M . 1A carbamates : aldicarb , alanycarb , bendio [ 0007 ] Insecticides commonly used to control stinkbugs carb , benfuracarb, butocarboxim , butoxycarboxim , car include pyrethroids, neonicotinoids and organophosphates, baryl, carbofuran , carbosulfan , ethiofencarb , fenobucarb , though pyrethroid insecticides are usually the method of formetanate , furathiocarb , isoprocarb , methiocarb , choice for controlling stink bugs in soybean . However, there methomyl, metolcarb , oxamyl , pirimicarb , propoxur, thio are increasing problems with insecticide resistance , particu dicarb , thiofanox , trimethacarb , XMC , xylylcarb and tri larly in brown stink bug populations and particularly to azamate ; and pyrethroids . Euschistus heros can also be difficult to manage [0022 ] II - M . 1B organophosphates, for example acephate , using organophosphates or endosulfan ( Sosa -Gomez et al . , azamethiphos , azinphos - ethyl , azinphosmethyl, cadusa 2009 ) . There is therefore a need for effective ecological fos, chlorethoxyfos , chlorfenvinphos, chlormephos , chlo methods of controlling stinkbugs in soybean . rpyrifos, chlorpyrifos -methyl , coumaphos, cyanophos, [0008 ] Particularly insecticides acting on the gamma demeton - S -methyl , diazinon , dichlorvos /DDVP , dicroto aminobutyric acid (GABA ) - gated chloride channel (dis phos, dimethoate , dimethylvinphos, disulfoton , EPN , closed in e . g . WO 2005 /085216 (EP1731512 ) , WO2009 / ethion , ethoprophos, famphur, fenamiphos , fenitrothion , 002809 and WO2009 /080250 ) seem to be effective for fenthion , fosthiazate , heptenophos , imicyafos , isofen controlling stinkbugs , especially in soybean such as phos, isopropyl O - (methoxyaminothio -phosphoryl ) described in WO2012/ 104331. salicylate , isoxathion , malathion , mecarbam , methami [ 0009 ] One typical problem arising in the field of pest dophos, methidathion , mevinphos ,monocrotophos , naled , control lies in the need to reduce the dosage rates of the omethoate , oxydemeton -methyl , parathion , parathion active ingredient in order to reduce or avoid unfavorable methyl, phenthoate , phorate , phosalone , phosmet, phos environmental or toxicological effects whilst still allowing phamidon , phoxim , pirimiphos -methyl , profenofos, pro effective pest control. petamphos , prothiofos, pyraclofos, pyridaphenthion , [0010 ] Another problem encountered concerns the need to quinalphos, sulfotep , tebupirimfos, temephos , terbufos, have available pest control agents which are effective tetrachlorvinphos , thiometon , triazophos , trichlorfon and against a broad spectrum of pests . vamidothion ; US 2019 /0281835 A1 Sep . 19 , 2019 [ 0023 ] II - M . 2 .GABA - gated chloride channel antagonists : [0048 ] II - M . 13 Uncouplers of oxidative phosphorylation [ 0024 ] II - M .2A cyclodiene organochlorine compounds: via disruption of the proton gradient : chlorfenapyr, endosulfan or chlordane; and DNOC , and sulfluramid ; [0025 ] II - M . 2B fiproles: ethiprole , fipronil, flufiprole , ( 0049 ] II - M . 14 Nicotinic acetylcholine receptor channel pyrafluprole and pyriprole ; blockers : bensultap , cartap hydrochloride , thiocyclam , [0026 ] II - M . 3 Sodium channel modulators : and thiosultap sodium ; [0027 ] II- M .3A pyrethroids: acrinathrin , allethrin , d -cis [0050 ] II - M . 15 Inhibitors of the chitin biosynthesis type 1 : trans allethrin , d - trans allethrin , bifenthrin , bioallethrin , bistrifluron , chlorfluazuron , diflubenzuron , flucycloxuron , bioallethrin S - cylclopentenyl, bioresmethrin , cyclopro flufenoxuron ,
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  • Ginkgolide B Modulates BDNF Expression in Acute Ischemic Stroke

    Ginkgolide B Modulates BDNF Expression in Acute Ischemic Stroke

    Laboratory Investigation J Korean Neurosurg Soc 60 (4) : 391-396, 2017 https://doi.org/10.3340/jkns.2016.1010.018 pISSN 2005-3711 eISSN 1598-7876 Ginkgolide B Modulates BDNF Expression in Acute Ischemic Stroke Hu Wei, M.D.,1 Tao Sun, M.D.,2 Yanghua Tian, M.D.,3 Kai Wang, M.D.3 Department of Neurology,1 Affiliated Provincial Hospital of Anhui Medical University, Hefei, China Department of Neurology,2 Nanjing General Hospital of Nanjing Command, Nanjing, China Department of Neurology,3 the First Hospital of Anhui Medical University, Hefei, China Objective : To investigate the neuroprotective effects of Ginkgolide B (GB) against ischemic stroke-induced injury in vivo and in vitro, and further explore the possible mechanisms concerned. Methods : Transient middle cerebral artery occlusion (tMCAO) mice and oxygen-glucose deprivation/reoxygenation (OGD/R)- treated N2a cells were used to explore the neuroprotective effects of GB. The expression of brain-derived neurotrophic factor (BDNF) was detected via Western blot and qRT-PCR. Results : GB treatment (4 mg/kg, i. p., bid) significantly reduced neurological deficits, water content, and cerebral infarct volume in tMCAO mice. GB also significantly increased Bcl-2/Bax ratio, reduced the expression of caspase-3, and protected against OGD/ R-induced neuronal apoptosis. Meanwhile, GB caused the up-regulation of BDNF protein in vivo and in vitro. Conclusion : Our data suggest that GB might protect the brain against ischemic insult partly via modulating BDNF expression. Key Words : Stroke · Ginkgolide B · Brain-derived neurotrophic factor · Apoptosis. INTRODUCTION detailed understanding of the mechanisms involved will have a substantial effect in the optimization and development of Ischemic stroke is the most common acute neurologic dis- treatment strategies.
  • Options for Managing Antestiopsis Thunbergii (Hemiptera: Pentatomidae) and the Relationship of Bug Density to the Occurrence of Potato Taste Defect in Coffee

    Options for Managing Antestiopsis Thunbergii (Hemiptera: Pentatomidae) and the Relationship of Bug Density to the Occurrence of Potato Taste Defect in Coffee

    Options for Managing Antestiopsis thunbergii (Hemiptera: Pentatomidae) and the Relationship of Bug Density to the Occurrence of Potato Taste Defect in Coffee Authors: Joseph Bigirimana, Andrew Gerard, David Mota-Sanchez, and Larry J. Gut Source: Florida Entomologist, 101(4) : 580-586 Published By: Florida Entomological Society URL: https://doi.org/10.1653/024.101.0418 BioOne Complete (complete.BioOne.org) is a full-text database of 200 subscribed and open-access titles in the biological, ecological, and environmental sciences published by nonprofit societies, associations, museums, institutions, and presses. Your use of this PDF, the BioOne Complete website, and all posted and associated content indicates your acceptance of BioOne’s Terms of Use, available at www.bioone.org/terms-of-use. Usage of BioOne Complete content is strictly limited to personal, educational, and non-commercial use. Commercial inquiries or rights and permissions requests should be directed to the individual publisher as copyright holder. BioOne sees sustainable scholarly publishing as an inherently collaborative enterprise connecting authors, nonprofit publishers, academic institutions, research libraries, and research funders in the common goal of maximizing access to critical research. Downloaded From: https://bioone.org/journals/Florida-Entomologist on 1/24/2019 Terms of Use: https://bioone.org/terms-of-use Options for managing Antestiopsis thunbergii (Hemiptera: Pentatomidae) and the relationship of bug density to the occurrence of potato taste defect in coffee Joseph Bigirimana1,*, Andrew Gerard2, David Mota-Sanchez1, and Larry J. Gut1 Abstract Potato taste defect is a potato-like smell found in green and roasted coffee beans. Potato taste defect reduces the flavor experience of finished coffee and causes it to be rejected by consumers.