bioRxiv preprint doi: https://doi.org/10.1101/018929; this version posted June 19, 2015. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. A Chronological Atlas of Natural Selection in the Human Genome during the Past Half-million Years Hang Zhou1,2,10, Sile Hu1,2,10, Rostislav Matveev3,4, Qianhui Yu1,2, Jing Li1, Philipp Khaitovich1, Li Jin1,5, Michael Lachmann3,6, Mark Stoneking3, Qiaomei Fu7,8,9 & Kun Tang1 1Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China. 2University of Chinese Academy of Sceiences, Beijing 100049, China. 3Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany. 4Max Planck Institute for Mathematics in the Sciences, D-04103 Leipzig, Germany. 5MOE Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai 200433, China. 6Santa Fe Institute, Santa Fe, New Mexico 87501, USA. 7Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. 8Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA 9Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, IVPP, CAS, Beijing 100044, China. 10These authors contributed equally to this work. Correspondence could be addressed to K.T. (
[email protected]) bioRxiv preprint doi: https://doi.org/10.1101/018929; this version posted June 19, 2015. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.