medRxiv preprint doi: https://doi.org/10.1101/2020.05.31.20118323; this version posted April 12, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. 1 2 Cortical re-organization after traumatic brain injury elicited using 3 functional electrical stimulation therapy: A case report 4 5 6 Matija Milosevic1,†,*, Tomoya Nakanishi2,3,†, Atsushi Sasaki2,3, Akiko Yamaguchi2, Taishin 7 Nomura1, Milos R. Popovic4,5,6, Kimitaka Nakazawa2 8 9 † Equally contributing authors. 10 11 1 Graduate School of Engineering Science, Department of Mechanical Science and 12 Bioengineering, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan. 13 2 Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8- 14 1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan. 15 3 Japan Society for the Promotion of Science, Kojimachi, Chiyoda-ku, Tokyo, Japan. 16 4 Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, 17 Ontario, M5S 3G9, Canada. 18 5 KITE, Toronto Rehabilitation Institute - University Health Network, 550 University Ave., 19 Toronto, ON, M5G 2A2, Canada. 20 6 CRANIA, University Health Network, 550 University Ave., Toronto, ON, M5G 2A2, Canada. 21 22 Correspondence: 23 *Matija Milosevic, PhD 24 Assistant Professor - Osaka University 25 Graduate School of Engineering Science 26 1-3 Machikaneyama-cho, Building J 27 Toyonaka, Osaka 560-8531, Japan 28 Phone: +81-6-6850-6536; Fax: +81-6-6850-6534 29 E-mail:
[email protected] 30 Web: www.neuromet.org 31 32 Running title: FES therapy elicited cortical re-organization 33 34 Keywords: brain injury; functional electrical stimulation; functional electrical stimulation 35 therapy; neuroplasticity; rehabilitation.