Management of Antibiotic-Resistant Helicobacter Pylori Infection: Perspectives from Vietnam
Gut and Liver, Vol. 13 No. 5, September 2019, pp. 483-497 Review Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam Vu Van Khien1, Duong Minh Thang1, Tran Manh Hai2,3, Nguyen Quang Duat4, Pham Hong Khanh4, Dang Thuy Ha5, Tran Thanh Binh6, Ho Dang Quy Dung6, Tran Thi Huyen Trang2, and Yoshio Yamaoka7 Departments of 1GI Endoscopy and 2Molecular Biology, 108 Central Hospital, 3University of Science and Technology of Hanoi, 4Department of Gastroenterology, 103 Hospital, 5Department of Gastroenterology, National Children Hospital, Hanoi, 6Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Vietnam, and 7Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Oita, Japan Antibiotic resistance is the most important factor leading to ithromycin; Metronidazole the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary INTRODUCTION resistance to clarithromycin, metronidazole, amoxicillin, levo- floxacin, tetracycline, and multidrug in Vietnam. We searched In 1983, Marshall and Warren1 discovered Helicobacter py- the PubMed, EMBASE, Vietnamese National Knowledge lori–a gram-negative bacillus that infects the human stomach Infrastructure, and Vietnamese Biomedical databases from mucosa. Further studies confirmed that H. pylori is the main January 2000 to December 2016. The search terms in- cause of chronic gastritis, peptic ulcer disease, gastric marginal cluded the following: H. pylori infection, antibiotic (including zone/mucosa-associated lymphoid tissue (MALT) lymphoma clarithromycin, metronidazole, amoxicillin, levofloxacin, tetra- and gastric carcinoma.2-7 Recently, it has been suggested that H. cycline, and multidrug) resistance in Vietnam. The data were pylori may be associated with extraintestinal diseases, including summarized in an extraction table and analyzed manually.
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