Moocs: Expectations and Reality. Full Report

Total Page:16

File Type:pdf, Size:1020Kb

Moocs: Expectations and Reality. Full Report MOOCs: Expectations and Reality Full Report May 2014 Fiona M. Hollands, Ph.D. Devayani Tirthali, Ed.D. Center for Benefit-Cost Studies of Education Teachers College, Columbia University Table of Contents Acknowledgements ....................................................................................................................................... 6 Purpose of the Study and Intended Audience .............................................................................................. 6 Executive Summary ....................................................................................................................................... 7 Introduction ................................................................................................................................................ 18 Methods ...................................................................................................................................................... 22 What is a MOOC? Definitions and Characteristics ...................................................................................... 25 Definition of “MOOC” ............................................................................................................................. 25 Characteristics of MOOCs ....................................................................................................................... 30 Origins of the cMOOC: George Siemens ................................................................................................. 31 Origins of the cMOOC: Stephen Downes ................................................................................................ 33 Origins of the Modern MOOC (xMOOC): Article contributed by Andrew Ng and Jennifer Widom ...... 34 MOOC Derivatives ................................................................................................................................... 48 How and Why are Institutions Engaging with MOOCs? .............................................................................. 49 Goal 1: Extending Reach and Access ........................................................................................................... 53 Case 1: Virology for the Masses: Vincent Racaniello, Columbia University ............................................ 63 Case 2: Developmental Education MOOCs: Cuyahoga Community College’s Pre-Algebra CCC ............. 65 Goal 2: Building and Maintaining Brand ..................................................................................................... 67 Case 3: MOOCs to Increase Visibility: American Museum of Natural History MOOC Initiative ............. 71 Case 4: MOOCs for Recruitment: Academic Partnerships MOOC2Degree Initiative ............................. 72 Goal 3: Improving Economics: Reducing Costs or Increasing Revenues ..................................................... 74 Potential Cost Savings from MOOCs ....................................................................................................... 75 MOOCs as a Source of Revenue .............................................................................................................. 81 Case 5: Georgia Tech’s Online Master of Science in Computer Science Program .................................. 87 Goal 4: Improving Educational Outcomes .................................................................................................. 90 Case 6: Course Re-design to a Mastery-Based Model: Michael Cima, MIT .......................................... 100 Case 7: Re-designing Introduction to Circuit Analysis: Khosrow Ghadiri, San José State University .... 103 Goal 5: Innovation in Teaching and Learning ........................................................................................... 106 Case 8: Maximizing the Use of Technology in Learning: University of Oklahoma ................................ 110 Goal 6: Research on Teaching and Learning ............................................................................................. 112 Case 9: RELATE at MIT ........................................................................................................................... 119 Examples of Research being Conducted with MOOCs.............................................................................. 121 Types of Data Available from MOOCs ....................................................................................................... 127 Where are we with Data Mining, Learning Analytics, and MOOCs? ........................................................ 130 Resource Requirements and Costs of MOOCs .......................................................................................... 134 Hollands & Tirthali: MOOCs: Expectations and Reality May 2014 2 Case 10: Cost Analysis for Development and Delivery of Connectivism and Connected Knowledge (a cMOOC) ................................................................................................................................................. 141 Case 11: Costs of MOOC Production at a Large Midwestern University ............................................. 144 Case 12: American Museum of Natural History MOOC Initiative: Resource Requirements and Expected Benefits.................................................................................................................................. 146 Case 13: Time-by-Task and Cost Analysis for Big Data in Education Development and Delivery ........ 148 Where are MOOCs Going over the Next Five Years? ................................................................................ 152 I. How MOOCs will Evolve as Courses ................................................................................................... 155 II. How MOOCs could Affect the Economic Model of Higher Education .............................................. 160 III. How MOOCs can Facilitate Relationships among Institutions ......................................................... 164 Conclusions and Recommendations ......................................................................................................... 167 References ................................................................................................................................................ 171 Appendices ................................................................................................................................................ 180 Appendix I: Institutional Affiliations and Roles of Interviewees ........................................................... 180 Appendix II: MOOCs: Expectations and Reality Interview Protocol ...................................................... 181 Appendix III: What Institutions are Doing in the MOOCspace.............................................................. 182 Appendix IV: Costs of Online Video Production .................................................................................... 197 Appendix V: Sample Pre- and Post-MOOC Participant Surveys ............................................................ 200 Appendix VI: List of Interviewees .......................................................................................................... 208 Hollands & Tirthali: MOOCs: Expectations and Reality May 2014 3 List of Tables Table ES 1: Institutional Goals for Developing and Delivering or Using MOOCs .......................................... 8 Table ES 2: Estimated Costs of MOOC Production and Delivery at Four Institutions ................................. 12 Table ES 3: Ideas Raised by Interviewees about MOOCs in the Future of Education................................. 14 Table 1: Institutional Affiliations of Interviewees ....................................................................................... 24 Table 2: Institutional Goals for Developing and Delivering or Using MOOCs ............................................. 50 Table 3: Preliminary Instructional and Support Staffing Plans for Georgia Tech’s OMSCS Program ......... 88 Table 4: Summary Projected Costs and Revenues for Georgia Tech’s OMSCS Program ............................ 89 Table 5: Estimated Costs of MOOC Production and Delivery at Four Institutions ................................... 139 Table 6: Estimated Replication Costs for the First Run of CCK08 and Re-run .......................................... 142 Table 7: Range of Hours Spent per MOOC on Design, Production, and Delivery at a Large Midwestern University .................................................................................................................................................. 144 Table 8: Range of Estimated Personnel Costs per MOOC for Design, Production, and Delivery at a Large Midwestern University .............................................................................................................................. 144 Table 9: Personnel Hours Spent by AMNH to Develop Three MOOCs ..................................................... 147 Table 10: Personnel Costs for Big Data in Education Development and Delivery .................................... 150 Table 11: Estimated Replication Costs of Big Data in Education under Various Assumptions................. 151 Table 12: Professional Productivity Changes as a Result of Time Devoted to Big Data in Education ...... 151 Table 13: Ideas Raised by Interviewees about MOOCs in the Future of Education ................................. 154 Table A.1 Institutional Affiliations and Roles of Interviewees
Recommended publications
  • CVM-Enews 2017 Mar.Pdf (970.1Kb)
    CVM eNews - March 2017 http://campaign.r20.constantcontact.com/render?m=1106633030128&c... March 2017 eNews March 2017 Consultant Launches an App Cornell Consultant, the diagnostic support search engine, and arguably the primary trusted knowledge-base for veterinarians around the world is now available as an app. READ MORE Diversity Town Hall Nearly 100 members of the CVM community attended a Diversity Town Hall in February. The event was hosted by VOICE and led by Lisa Greenhill, who oversees the DiVersity Matters initiative for the AAVMC READ MORE Don Smith Memorial Service Please join us for a memorial service for Professor and Dean Emeritus Donald F. Smith on Monday, March 27th at the Moakley House. READ MORE International Programs CVM welcomed international colleagues to give seminars in February, including faculty from City University at Hong Kong and Obihiro University of Agriculture and Veterinary Medicine. READ MORE 1 of 3 3/8/2017 4:53 PM CVM eNews - March 2017 http://campaign.r20.constantcontact.com/render?m=1106633030128&c... Baker Pet Talks - Tips from Cornell Experts Dr. Dan Fletcher will lecture on the basics of Pet CPR. READ MORE Class Expansion Construction Update Construction of the new cafeteria continues and the new curtain wall is being installed on the new Library wing and courtyard side of the new Atrium. Learn about the progress. READ MORE Hellos and Goodbyes Meet the new employees who joined us in February. READ MORE Upcoming Events Date Event 3/9 Thu Trans 101: Gender Identity Concepts and Terminology, Caitlin Hepps Keeney, DVM'18 (11:30-12:30 pm, LH3) 3/9 Thu Van Gogh Vets (8:00 am - 7:00 pm, The Old Breezeway) 3/9 Thu Students vs.
    [Show full text]
  • JOURNAL of VIROLOGY VOLUME 62 * SEPTEMBER 1988 * NUMBER 9 Arnold J
    JOURNAL OF VIROLOGY VOLUME 62 * SEPTEMBER 1988 * NUMBER 9 Arnold J. Levine, Editor in Chief Thomas E. Shenk, Editor (1989) (1989) Princeton University Princeton University Princeton, N.J. Princeton, N.J. Michael B. A. Oldstone, Editor (1993) Anna Marie Skalka, Editor (1989) Bernard N. Fields, Editor (1993) Scripps Clinic & Research Fox Chase Cancer Center Harvard Medical School Foundation Philadelphia, Pa. Boston, Mass. La Jolla, Calif. George F. Vande Woude, Editor (1992) Robert A. Lamb Editor (1992) NCI-Frederick Cancer Research Facility Northwestern University Frederick Md. Evanston, Ill. EDITORIAL BOARD James Alwine (1988) Mary-Jane Gething (1990) Malcolm Martin (1989) Norman P. Salzman (1990) David Baltimore (1990) Joseph C. Glorioso (1989) Robert Martin (1990) Joseph Sambrook (1988) Amiya K. Banerjee (1990) Stephen P. Goff (1988) Warren Masker (1990) Charles E. Samuel (1989) Tamar Ben-Porat (1990) Larry M. Gold (1988) James McDougall (1990) Priscilla A. Schaffer (1990) Kenneth I. Berns (1988) Hidesaburo Hanafusa (1989) Thomas Merigan (1989) Sondra Schlesinger (1989) Michael Botchan (1989) John Hassell (1989) Lois K. Miller (1988) Manfred Schubert (1988) Thomas J. Braciale (1988) William S. Hayward (1990) Peter Model (1989) Bart Sefton (1988) Joan Brugge (1988) Ari H. Helenius (1990) Bernard Moss (1989) Bert L. Semler (1989) Michael J. Buchmeier (1989) Roger Hendrix (1990) Opendra Narayan (1988) Charles J. Sherr (1990) Barrie J. Carter (1990) John J. Holland (1990) Joseph R. Nevins (1988) Saul J. Silverstein (1988) Sherwood Casjens (1990) Nancy Hopkins (1989) Erling Norrby (1989) Patricia G. Spear (1990) John M. Coffin (1989) Alice S. Huang (1990) Nancy G. Nossal (1990) Bruce Stillman (1988) Charles N.
    [Show full text]
  • A Compendium of Case Studies and Interviews with Experts About Open Education Practices and Resources
    A Compendium of Case Studies and Interviews with Experts about Open Education Practices and Resources A Compendium of Case Studies and Interviews with Experts Practices about Open Education 1 To read the full report, please visit: www.openmedproject.eu This work is licensed under a Creative Commons Attribution 4.0 Inter- national License (CC BY 4.0). This means that you are free to: • Share – copy and redistribute the material in any medium or format • Adapt – remix, transform, and build upon the material You may do so for any purpose, even commercially. However, you must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Please credit this Executive Summary of the report to: Wimpenny, K., Merry, S.K., Tombs, G. & Villar-Onrubia, D. (eds) (2016), Opening Up Education in South Mediterranean Countries: A Compendi- um of Case Studies and Interviews with Experts about Open Education- al Practices and Resources. OpenMed, ISBN 978-1-84600-0 The European Commission support for the production of this publication does not con- stitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein. 2 Introduction OpenMed is an international cooperation project co-funded by the Erasmus + Capacity Building in HE programme of the European Union during the period 15 October 2015 - 14 October 2018 involving five partners from Europe and eight from South-Mediterranean (S-M) countries (Morocco, Palestine, Egypt and Jordan).
    [Show full text]
  • 5 Michael Schreiber Dissertation V3-NLM Formatted Illustrated
    Determinants of Human Rhinovirus Cellular Tropism in Monocyte-Lineage Cells Michael Schreiber Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy under the Executive Committee of the Graduate School of Arts and Sciences COLUMBIA UNIVERSITY 2016 © 2016 Michael Schreiber All rights reserved ABSTRACT Determinants of Human Rhinovirus Cellular Tropism in Monocyte-Lineage Cells Michael Schreiber Human rhinovirus (HRV) is responsible for the majority of common cold infections and asthma exacerbations. HRV predominantly replicates in the epithelial cells of the upper airway, where common cold symptoms are produced. However, HRV also enters the lower airway, encountering the epithelial cells and alveolar macrophages thought to produce inflammatory responses during HRV-induced asthma exacerbations. Notably, alveolar macrophages release inflammatory mediators such as MCP1/CCL2 and RANTES/CCL5 in response to HRV despite the fact that limited if any HRV replication occurs in these cells. The present study seeks to address the mechanism by which alveolar macrophages are susceptible but not permissive to HRV replication and to identify the step in the HRV replication cycle that restricts HRV to abortive replication in macrophages. Evidence presented herein demonstrates that major-group (ICAM-1 tropic) HRV replicate with limited success in cell line-derived macrophages, whereas minor-group (LDLR tropic) HRV do not replicate in these monocyte-lineage cells. In contrast, neither major- nor minor-group HRV replicate in primary human PBMC-derived macrophages. Capsid swap experiments demonstrated that difference in replicative capacity between major- and minor-group HRV is mediated at the level of permissiveness rather than susceptibility. RNA- Seq gene expression studies identified candidate host genes that may act to regulate HRV replication.
    [Show full text]
  • Hepatitis C Virus Utilizes VLDLR As a Novel Entry Pathway
    Hepatitis C virus utilizes VLDLR as a novel entry pathway Saneyuki Ujinoa,1, Hironori Nishitsujia, Takayuki Hishikib, Kazuo Sugiyamac, Hiroshi Takakud, and Kunitada Shimotohnoa,1 aResearch Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, 272-8516 Japan; bLaboratory of Primate Model, Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto, 606-8507 Japan; cDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582 Japan; and dResearch Institute, Chiba Institute of Technology, Tsudanuma, Narashino, Chiba 275-0016 Japan Edited by Vincent Racaniello, Columbia University College of Physicians/Surgeons, New York, NY, and accepted by the Editorial Board December 2, 2015 (received for review April 2, 2015) Various host factors are involved in the cellular entry of hepatitis C controls without liver disease (17). In vitro analysis has shown virus (HCV). In addition to the factors previously reported, we that during the early stage of infection HCV recognizes lipo- discovered that the very-low-density lipoprotein receptor (VLDLR) protein receptors such as SR-BI and LDLR on target cells via mediates HCV entry independent of CD81. Culturing Huh7.5 cells the association of the virus with apolipoprotein E (ApoE) or under hypoxic conditions significantly increased HCV entry as a other related ligands (18). However, the cell lines that have been result of the expression of VLDLR, which was not expressed under widely used for the analysis of HCV infection/replication (i.e., normoxic conditions in this cell line. Ectopic VLDLR expression Huh7 and its derivatives) do not express VLDLR under con- conferred susceptibility to HCV entry of CD81-deficient Huh7.5 cells.
    [Show full text]
  • 2016 Guide-On-Moocs-For-Policy
    United Nations Educational, Scientific and Cultural Organization Making Sense of MOOCs A Guide for Policy-Makers in Developing Countries Mariana Patru and Venkataraman Balaji Editors Published by the United Nations Educational, Scientic and Cultural Organization (UNESCO), 7, place de Fontenoy, 75352 Paris 07 SP, France, and Commonwealth of Learning (COL), 4710 Kingsway, Suite 2500, Burnaby, BC V5H 4M2, Canada © UNESCO and Commonwealth of Learning, 2016 ISBN 978-92-3-100157-4 This publication is available in Open Access under the Attribution-ShareAlike 3.0 IGO (CC-BY-SA 3.0 IGO) license (http://creativecommons.org/licenses/by-sa/3.0/igo/). By using the content of this publication, the users accept to be bound by the terms of use of the UNESCO Open Access Repository (http://www.unesco.org/open-access/terms-use-ccbysa-en) and the Co-Publisher Open Access Repository (http://oasis.col.org). The designations employed and the presentation of material throughout this publication do not imply the expression of any opinion whatsoever on the part of UNESCO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The ideas and opinions expressed in this publication are those of the authors; they are not necessarily those of UNESCO or COL and do not commit the Organizations. Editors: Mariana Patru and Venkataraman Balaji Cover design: Aurelia Mazoyer Cover photo: ©shutterstock/Katty2016 Designed and printed by UNESCO Printed in France Foreword by the President and CEO, Commonwealth of Learning COL’s interest in massive open online courses (MOOCs) is rooted in its mission to increase access to quality education and training in an equitable and affordable manner.
    [Show full text]
  • Engineered in Vitro Disease Models Kambez H
    PM10CH08-Ingber ARI 2 December 2014 10:14 Engineered In Vitro Disease Models Kambez H. Benam,1 Stephanie Dauth,1,2 Bryan Hassell,1,2 Anna Herland,1 Abhishek Jain,1 Kyung-Jin Jang,1 Katia Karalis,1,3,4 Hyun Jung Kim,1 Luke MacQueen,1,2 Roza Mahmoodian,1,2 Samira Musah,1 Yu-suke Torisawa,1 Andries D. van der Meer,1 Remi Villenave,1 Moran Yadid,1,2 Kevin K. Parker,1,2 and Donald E. Ingber1,2,5 1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115; email: [email protected] 2Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts 02139 3Division of Endocrinology, Boston Children’s Hospital, Boston, Massachusetts 02115 4Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens (BRFAA), 11527 Athens, Greece 5Vascular Biology Program and Departments of Pathology and Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 Annu. Rev. Pathol. Mech. Dis. 2015. 10:195–262 Keywords The Annual Review of Pathology: Mechanisms of disease model, tissue engineering, 3D culture, organ-on-a-chip, Disease is online at pathol.annualreviews.org microfluidic, in vitro tool This article’s doi: 10.1146/annurev-pathol-012414-040418 Abstract Copyright c 2015 by Annual Reviews. The ultimate goal of most biomedical research is to gain greater insight into All rights reserved mechanisms of human disease or to develop new and improved therapies or diagnostics. Although great advances have been made in terms of developing disease models in animals, such as transgenic mice, many of these models fail to faithfully recapitulate the human condition.
    [Show full text]
  • Persistent Infections Lecture 17 Biology 3310/4310 Virology Spring 2017
    Persistent Infections Lecture 17 Biology 3310/4310 Virology Spring 2017 Paralyze resistance with persistence –WOODY HAYES Acute vs persistent infections • Acute infection - rapid and self-limiting • Persistent infection - long term, life of host • Stable, characteristic for each virus • Most persistent infections probably begin as an acute infection Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University General patterns of infection Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Principles of Virology, ASM Press Persistent infections • Occur when primary infection is not cleared by immune response • Virions, protein, genomes continue to be produced • Viral genomes may remain after proteins are not detected Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Persistent infections • No single mechanism • When cytopathic effects are absent and host defenses are reduced, persistent infection is likely • Viral immune modulation Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Persistent human infections * * * * * * * * * Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Principles of Virology, ASM Press The cytotoxic T lymphocyte response Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Principles of Virology, ASM Press Modulation of MHC I system Virology Lectures 2017 • Prof. Vincent Racaniello • Columbia University Principles of Virology, ASM Press CTL escape mutants • Herpes simplex virus • Hepatitis C virus Changes
    [Show full text]
  • Understanding the Biden Win from an Aesthetic Perspective Pierce Henderson 8
    PRESIDENT FOX NEWS SHUTDOWNS MODERNAPRESIDENT FOX NEWS SHUTDOWNS MODERNA ELECTION BELFER CENTER FOR SCIENCE ELECTION& BELFER CENTER FOR SCIENCE & INTERNATIONAL AFFAIRS CONGRESS JOSEPH R. INTBIDEERNATIONALN AFFAIRS CONGRESSIn This Issue: JOSEPH R. BIDEN Kennedy 8 | Understanding the Biden Win from TRUTH CONSERVATIVE ZOOM CHINA AMERI TRUTHCAN CONSERVATIVE ZOOMan Aesthetic CHINA Perspective AMERICAN ENTERPRISE INSTITUTE SENATE85 | OF A Clash betweenTHE Classical UNITED Liberalism, STATES ENTERPRISE INSTITUTE SENATE OF THE UNITED STATESSchool Public Health, and the Constitution SCHOOLS NANCY PELOSI WALL STREET JOUR SCHOOLSNAL NANCY PELOSI 56 |WALL On Race, Womanhood, STREET and Medicine JOURNAL LOCKDOWN JOHNSON & JOHNSON CENTER LOCKDOWNFORReview JOHNSON & JOHNSON CENTER FOR AMERICAN PROGRESS SOCIAL DISTANCING AM FERICANREE PROGRESS SOCIAL DISTANCING FREE MARKETS MIKE PENCE WASHINGTON POST RECESSMAIORKETSN MIKE PENCE WASHINGTON POST RECESSION STIMULUS VOTING MASKS CAPITOL HILL HERIT STAGEIMULUS VOTING MASKS CAPITOL HILL HERITAGE FOUNDATION WUHAN RESTORE THE SOUL OFFO UNDATIONTHE WUHAN RESTORE THE SOUL OF THE COUNTRY NEW YORK TIMES MITCH MCCONNELLCO CNUNTRYN NEW20 YORK TIMES MITCH20 MCCONNELL CNN JOURNALIST IN-PERSON FREEDOM HOUSE J OURNALISTOF IN-PERSON FREEDOM HOUSE OF REPRESENTATIVES VACCINE DIPLOMACY PROGRESREPRESENTATIVESSIVE VACCINE DIPLOMACY PROGRESSIVE ECONOMY JUSTICE RECALL SHORENSTEIN CEN ECONOMYTER 20JUSTICE RECALL SHORENSTEIN21 CENTER INSURRECTION LIBERTY EQUALITY SPACE FORCE INPRSURRECTIONESS LIBERTY EQUALITY SPACE FORCE PRESS CORPS
    [Show full text]
  • Mapping of Shared Economy Platforms
    Mapping of Shared Economy Platforms The Mapping of Shared Economy Platforms has been produced with the technical assistance of 1 TABLE OF CONTENT A. Background and Context B. Purpose of the mission C. Methodology D. Preliminary Findings E. Selection of platforms for further analysis F. Analysis of the platforms G. Recommendations H. About Jamaity The Mapping of Shared Economy Platforms has been produced with the technical assistance of 2 A. Background and Context Within the framework of developing the second generation of the Sharing Economy Platform Youth Without Borders (YWB) in coordination with the Innovation for Change MENA Hub, a mapping will be conducted with the objective of analyzing and understanding the existing similar platforms in the MENA region (their work, target, challenges faced, needs, contain and potential growth and development.). The second generation of the Sharing Economy Platform will be developed to create an inclusive and supportive space. Comprised of civil society organizations from the MENA region, this generation will promote the exchange of services and knowledge among the to strengthen their capacities and encourage dynamic fundraising that enables civic activism across the MENA region. By Conducting a comparative analysis of the existing Sharing Economy Platforms in the MENA region and an assessment of potential features to be developed, this mapping will help form the following: a clear understanding on how to build and manage a platform, a deeper idea on how to set the objectives of the platform, the services, the rules and the benefits of the members. B. Purpose of the mission This mission consists in conducting a mapping on the Sharing Economy Platforms exiting in the MENA region.
    [Show full text]
  • This Week in Virology Episode 3: Dengue
    This Week in Virology with Vincent Racaniello, Ph.D. and Dick Despommier, Ph.D. Episode 3: Dengue Aired 2 October 2008 http://www.twiv.tv/2008/10/02/twiv-3-dengue/ Vincent Racaniello: I'm Vincent Racaniello. Dick Despommier: And I'm Dick Despommier. Vincent: How have you been, Dick? Dick: I’ve been well, Vince. Did you have a good week? Vincent: Have you built any vertical farms? Dick: No. In my dreams. Vincent: Beautiful day. No rain today. Dick: Nope. Vincent: What are we talking about today? Dick: We had a little rain yesterday, though, so that might have jump started a few batches of mosquitoes. Yes, I think so. Vincent: Weather is hard to predict, isn’t it? Dick: It's impossible. Vincent: Dick, I know we are talking about Dengue today but before we do I found a new news item which we should discuss because it’s timely. Every day I scour the internet for articles on viruses. Do you know what most of the returns are about? Computer viruses. Dick: Hah, hah, hah. Vincent: Some of them are about the viruses that infect you which is what we talk about on this podcast. Listen to this headline: Researchers link home foreclosures to West Nile Virus outbreaks. So apparently you know we are having a financial crisis. Everyone seems to know except John McCain. We can't be political in this podcast otherwise people won’t listen to us. In California, a study was done. This is published in the journal called “Emerging Infectious Diseases,” which is a publication of the Centers for Disease Control and Prevention and we'll put the link in the show notes for this.
    [Show full text]
  • Picornaviruses: Pathogenesis and Molecular Biology
    UC Irvine UC Irvine Previously Published Works Title Picornaviruses: Pathogenesis and Molecular Biology Permalink https://escholarship.org/uc/item/9gk1997c ISBN 9780128012383 Authors Cathcart, AL Baggs, EL Semler, BL Publication Date 2014-12-15 DOI 10.1016/B978-0-12-801238-3.00272-5 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Picornaviruses: Pathogenesis and Molecular Biology AL Cathcart, EL Baggs, and BL Semler, University of California, Irvine, CA, USA Ó 2015 Elsevier Inc. All rights reserved. Glossary Cre (cis-acting replication element) An RNA hairpin in Positive-strand RNA An RNA molecule that is functional as picornavirus genomic RNA that acts as a template for mRNA and can be used in translation. Picornavirus uridylylation of VPg (viral protein, genome linked) to VPg- genomes exist as positive-sense RNAs. pU-pU by the RNA polymerase 3D. Quasi-species A collection of variant but related genotypes Enteric virus A virus that preferentially replicates in the or individuals that make up a species. In viruses, this refers intestine or gut of a host. For picornaviruses, these include to the genetic diversity that allows viral populations to poliovirus, coxsackievirus, echovirus, and enterovirus 71. adapt to changing environments. IRES (Internal Ribosome Entry Site) A highly structured Uridylylation The addition of uridylyl groups to a protein RNA element at the 50 end of some cellular and viral or nucleic acid. In the case of picornaviruses, the viral RNA mRNAs that directs translation via a cap-independent polymerase 3D uridylylates VPg using an RNA template for mechanism. use as a protein primer for replication.
    [Show full text]