PM10CH08-Ingber ARI 2 December 2014 10:14 Engineered In Vitro Disease Models Kambez H. Benam,1 Stephanie Dauth,1,2 Bryan Hassell,1,2 Anna Herland,1 Abhishek Jain,1 Kyung-Jin Jang,1 Katia Karalis,1,3,4 Hyun Jung Kim,1 Luke MacQueen,1,2 Roza Mahmoodian,1,2 Samira Musah,1 Yu-suke Torisawa,1 Andries D. van der Meer,1 Remi Villenave,1 Moran Yadid,1,2 Kevin K. Parker,1,2 and Donald E. Ingber1,2,5 1Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115; email:
[email protected] 2Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts 02139 3Division of Endocrinology, Boston Children’s Hospital, Boston, Massachusetts 02115 4Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens (BRFAA), 11527 Athens, Greece 5Vascular Biology Program and Departments of Pathology and Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 Annu. Rev. Pathol. Mech. Dis. 2015. 10:195–262 Keywords The Annual Review of Pathology: Mechanisms of disease model, tissue engineering, 3D culture, organ-on-a-chip, Disease is online at pathol.annualreviews.org microfluidic, in vitro tool This article’s doi: 10.1146/annurev-pathol-012414-040418 Abstract Copyright c 2015 by Annual Reviews. The ultimate goal of most biomedical research is to gain greater insight into All rights reserved mechanisms of human disease or to develop new and improved therapies or diagnostics. Although great advances have been made in terms of developing disease models in animals, such as transgenic mice, many of these models fail to faithfully recapitulate the human condition.