JOURNAL OF VOLUME 62 * SEPTEMBER 1988 * NUMBER 9 Arnold J. Levine, Editor in Chief Thomas E. Shenk, Editor (1989) (1989) Princeton University Princeton University Princeton, N.J. Princeton, N.J. Michael B. A. Oldstone, Editor (1993) Anna Marie Skalka, Editor (1989) Bernard N. Fields, Editor (1993) Scripps Clinic & Research Fox Chase Cancer Center Harvard Medical School Foundation Philadelphia, Pa. Boston, Mass. La Jolla, Calif. George F. Vande Woude, Editor (1992) Robert A. Lamb Editor (1992) NCI-Frederick Cancer Research Facility Northwestern University Frederick Md. Evanston, Ill. EDITORIAL BOARD James Alwine (1988) Mary-Jane Gething (1990) Malcolm Martin (1989) Norman P. Salzman (1990) (1990) Joseph C. Glorioso (1989) Robert Martin (1990) Joseph Sambrook (1988) Amiya K. Banerjee (1990) Stephen P. Goff (1988) Warren Masker (1990) Charles E. Samuel (1989) Tamar Ben-Porat (1990) Larry M. Gold (1988) James McDougall (1990) Priscilla A. Schaffer (1990) Kenneth I. Berns (1988) Hidesaburo Hanafusa (1989) Thomas Merigan (1989) Sondra Schlesinger (1989) Michael Botchan (1989) John Hassell (1989) Lois K. Miller (1988) Manfred Schubert (1988) Thomas J. Braciale (1988) William S. Hayward (1990) Peter Model (1989) Bart Sefton (1988) Joan Brugge (1988) Ari H. Helenius (1990) Bernard Moss (1989) Bert L. Semler (1989) Michael J. Buchmeier (1989) Roger Hendrix (1990) Opendra Narayan (1988) Charles J. Sherr (1990) Barrie J. Carter (1990) John J. Holland (1990) Joseph R. Nevins (1988) Saul J. Silverstein (1988) Sherwood Casjens (1990) Nancy Hopkins (1989) Erling Norrby (1989) Patricia G. Spear (1990) John M. Coffin (1989) Alice S. Huang (1990) Nancy G. Nossal (1990) Bruce Stillman (1988) Charles N. Cole (1989) Steve Hughes (1988) Dennis O'Callaghan (1989) Mark F. Stinski (1989) Neal Copeland (1989) Eric Hunter (1990) Joseph Pagano (1990) James Strauss (1990) Donald Court (1990) Tony Hunter (1989) Takis Papas (1990) F. William Studier (1990) Richard Courtney (1989) Richard Hyman (1989) J. Thomas Parsons (1989) Lawrence S. Sturman (1988) Clyde S. Crumpacker II Nancy Jenkins (1989) Ulf G. Pettersson (1989) Bill Sugden (1990) (1988) Richard A. Katz (1990) Lennart Philipson (1990) John M. Taylor (1990) Bryan R. Cullen (1990) Jack D. Keene (1988) Lewis I. Pizer (1990) Howard M. Temin (1988) Thomas Curran (1988) Thomas J. Kelly, Jr. (1988) Carol Prives (1989) Inder Verma (1989) Walter Doerfler (1989) Eli Keshet (1990) Vincent Racaniello (1990) Volker M. Vogt (1990) Elvera Ehrenfeld (1989) Elliott Kieff (1990) R. Frank Ramig (1988) Edward K. Wagner (1989) Robert N. Eisenman (1988) David Knipe (1988) Fred Rapp (1990) Raymond M. Welsh, Jr. (1988) Suzanne U. Emerson (1989) Daniel Kolakofsky (1989) Dan S. Ray (1989) Gail Wertz (1988) Mary K. Estes (1989) Hsing-Jien Kung (1990) Solon L. Rhode (1989) Reed B. Wickner (1988) Ellen Fanning (1988) Ching-Juh Lai (1990) Harriet Robinson (1988) Eckard Wimmer (1988) Emanuel A. Faust (1990) Michael Lai (1988) William S. Robinson (1989) Owen Witte (1989) S. Jane Flint (1990) Robert A. Lazzarini (1990) Bernard Roizman (1988) Charles Hamish Young (1989) Donald Ganem (1988) Myron Levine (1988) John K. Rose (1988) Harald zur Hausen (1989) Costa Georgopolous (1989) Maxine Linial (1988) Naomi Rosenberg (1989) Walter Gerhard (1989) Douglas R. Lowy (1989) Roland R. Rueckert (1988) Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director of Publications Linda M. Illig, Managing Editor, Journals Judith Nedrow, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for , 1913 I St., N.W., Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, , morphology, physiology, and pathogenesis and . Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, one volume per year. The nonmember subscription price is $350 per year; single copies are $30. The member subscription price is $41 (foreign, $63 [air drop shipping]) per year; single copies are $8.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., N.W., Washington, DC 20006 (phone: 202 833-9680). 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Ahmed, Rafi, 3301 Geballe, Adam P., 3334 Li, Ruo-ping, 3233 Sato, Hiroshi, 3288 Alwine, James C., 3182 Geiduschek, E. Peter, 3455 Satoh, Shuichi, 3517 Anderson, Garth R., 3540 Glorioso, Joseph C., 3274 Mackow, Erich R., 3509 Sayre, Michael H., 3455 Ansorge, Wilhelm, 3341 Gompels, Ursula A., 3250 Manly, Kenneth F., 3540 Schickedanz, Jorg, 3341 Goodall, Jonathan, 3527 Manuelidis, Elias E., 3103 Scraba, Douglas G., 3474 Baglia, Laurel A., 3415 Gouilloud, Evelyne, 3328 Manuelidis, Laura, 3103 Sen, Ganes C., 3175 Barbosa, Miguel S., 3242 Greenberg, Harry B., 3509 Markowitz, Rhea-Beth, 3388 Senkowski, Andrea, 3527 Baumbach, William R., 3151 Guetta, E., 3438 Matloubian, Mehrdad, 3301 Shaw, George M., 3501 Bello, Leonard J., 3319 Guillon, Jean-Claude, 3484 Matsuda, Keizaburoh, 3517 Shaw, James E., 3415 Berman, Phillip W., 3135 McGuire, Travis C., 3488 Shaw, Robert D., 3509 Biempica, Luis, 3422 Haffar, Omar K., 3135 Melief, C. J. M., 3156 Shepard, Alyssa, 3364 Blais, Bruce P., 3431 Hahn, Beatrice H., 3501 Mdric, Claude, 3328 Simon, Richard S., 3301 Bockman, Jeffrey M., 3120 Harty, John T., 3210 Miller, Lois K., 3109 Smith, Frances I., 3084 Britt, William J., 3309 Hayami, Masanori, 3506 Minson, Anthony C., 3274 Snyder, Robert, 3422 Brown, David W., 3431 Hemstrom, Catharina, 3258 Mocarski, Edward S., 3334 Southern, Peter J., 3301 Byrn, Randal A., 3274 Henner, Dennis J., 3193 Monroe, James E., 3497 Spahr, Pierre-Frangois, 3328 Byrne, Janet C., 3143 Henry, Catherine, 3233 Morgan, William C., 3407 Spalholz, Barbara A., 3143 Herr, Winship, 3364 Morrow, Casey D., 3501 Spector, Deborah H., 3463 Calender, Alain, 3497 Hilgers, Jo, 3506 Muggeridge, Martin I., 3274 Spegelaere, P., 3438 Carter, Barrie J., 3356 Hintz, Ray, 3422 Mulder, Carel, 3497 Spivack, Jordan G., 3281, Celis, Esteban, 3128 Hodges, Robert S., 3474 Murdoch, Geoffrey, 3103 3493 Cheevers, William P., 3488 Holmes, Ian H., 3509 Spruyt, N., 3438 Chisholm, George E., 3193 Honess, Robert W., 3250 Nicholas, John, 3250 Staprans, Silvija I., 3463 Choubey, Divaker, 3175 Hood, Leroy E., 3501 Nordqvist, Katarina, 3258 Stehelin, Dominique, 3233 Claessens, Johnny A. J., 3092 Hovanessian, Ara G., 3077 Norton, Linda K., 3488 Steiner, Israel, 3493 Clarke, Jennifer, 3364 Hovi, Tapani, 3536 Nunes, Wylla M., 3135 Stephens, Edward B., 3309 Cohen, Gary H., 3274 Howley, Peter M., 3143 Stillman, Bruce, 3445 Cole, Michael D., 3151 O'Boyle, Donald R., II, 3493 Daniel 3540 Ohara, Yoshiro, 3527 Stoler, L., Colston, Elizabeth M., 3151 Isola, Vicki J., 3274 Strynadka, Natalie C. J., 3474 Cornelis, J. J., 3438 Ohori, Hitoshi, 3517 Su, Chun Yeh, 3422 Cotmore, S. F., 3438 Oleszak, Emilia L., 3103 Jameson, Bradford A., 3501 Subramani, Suresh, 3378 Craxton, Molly A., 3250 O'Reilly, David R., 3109 Summers, J., 3513 Crumpacker, Clyde S., 3224 J0rgensen, Eva C., 3217 Oroszlan, Stephen, 3167 J0rgensen, Poul, 3217 O'Rourke, Katherine I., 3488 Dabrowski, Christine, 3182 Ou, Dawei, 3128 Tal, J., 3438 Dales, S., 3371 Kano-Sueoka, Tamiko, 3201 Tong, Jennifer, 3265 Darawshi, T., 3438 Kaplan, David R., 3407 Pagano, Joseph S., 3288 Toth, Marcia, 3527 Debuire, Brigitte, 3233 Kappes, John C., 3501 Palese, Peter, 3084, 3348 Trempe, James P., 3356 de Goede, R. E. Y., 3156 Kasher, Mary S., 3295 Pallas, David C., 3407 Tsai, Wen-Po, 3167 Denton, Amy, 3445 Kent, Stephen B. H., 3501 Parker, J. M. Robert, 3474 Tucker, Thomas J., 3274 Derse, David, 3522 King, David M., 3201 Pedersen, Finn S., 3217 Deyerle, Karen L., 3378 Kingsbury, David T., 3120 Pepperkok, Rainer, 3341 Dietzschold, Bernhard, 3128 Kjeldgaard, Niels O., 3217 Pettersson, Ulf, 3258 van der Vliet, Peter C., 3092 Dorn, Patricia L., 3522 Klaman, Lori, 3527 Philipson, Lennart, 3341 van Miltenburg, Rob T., 3092 Dorsky, David I., 3224 Klein, Rudiger, 3341 Plagemann, Peter G. W., 3210 Vasmel, W. L. E., 3156 Duterque-Coquillaud, Martine, Koike, K., 3513 Pruijn, Ger J. M., 3092 Vazeille, Marie Christine, 3233 Kolhekar, Suhas R., 3301 Puchtler, Iris, 3530 3484 Dyall-Smith, Michael L., 3509 Koprowski, Hilary, 3128 Pugh, J. C., 3513 Virtanen, Anders, 3258 Dynan, William S., 3388 Koszinowski, Ulrich H., 3341 Vugler, Leone, 3309 Krystal, Mark, 3348 Raab-Traub, Nancy, 3288 Kumar, Rakesh, 3175 Rabert, Douglas K., 3463 Edbauer, Cheryl, 3265 Wettstein, Felix O., 3242 Eisenberg, Roselyn J., 3274 Kyuwa, Shigeru, 3506 Radaszkiewicz, T., 3156 Redmond, Mark J., 3474 Whitbeck, J. Charles, 3319 Fleckenstein, Bernhard, 3530 Lamberti, Carmela, 3265 Richter, Jutta, 3530 White, Eileen, 3445 Flenniken, Ann M., 3077 Lavi, Ehud, 3493 Roberts, Thomas M., 3407 Williams, Bryan R. G., 3077 Flourens, Anne, 3233 Lawrence, William C., 3319 Robinson, Harriet L., 3431 Williams, Jim, 3265 Fraser, Nigel W., 3281, 3493 Lazdins, leva, 3509 Rogler, Charles E., 3422 Wilson, G. A. R., 3371 Freedman, Douglas M., 3301 Lee, Shei-Wen, 3501 Roivainen, Merja, 3536 Fu, Jianlin, 3527 Lee, Young, 3422 Roman, Ann, 3295 Yaginuma, K., 3513 Fu, Xi-xian, 3422 Leider, Jason M., 3084 Rommelaere, J., 3438 Yamaguchi, Kenjiro, 3506 Fujiwara, Kosaku, 3506 Lengyel, Peter, 3175 Roos, Raymond P., 3527 Yamashita, Makoto, 3348 Leprince, Dominique, 3233 Rosen, Leon, 3484 Galabru, Julien, 3077 Leung, Kiu, 3415 Rueckert, Roland R., 3399 Gallagher, Thomas M., 3399 Leupers, C. J. M., 3156 Rutherford, Michael N., 3077 Zijlstra, M., 3156 THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNOUNCES

The Second AACR Special Conference in Cancer Research THE ROLE OF DNA VIRUSES IN HUMAN TUMORS

January 22-26, 1989 Catamaran Resort Hotel, San Diego, California

PROGRAM COMMITTEE

Harald zur Hausen, Chairman George Miller Jesse Summers

SCIENTIFIC PROGRAM KEYNOTE ADDRESS (An Anniversary in Virus Research REGULATION OF VIRAL GENE EXPRESSION IN in Human Tumors) LATENTLY INFECTED CELLS "Twenty-five Years of Epstein-Barr Virus Research: J. Summers, Philadelphia, PA Present State and Perspectives," M. A. Epstein, E. Kieff, Boston MA Oxford, UK A. Sergeant, Lyon, France P. Howley, Bethesda, MD DNA TUMOR VIRUSES: CONCEPTS AND NEW DEVELOPMENTS MECHANISMS OF TRANSFORMATION AND R. Dulbecco, La Jolla, CA IMMORTALIZATION R. P. Beasley, San Francisco, CA L. Laimins, Chicago, IL H. zur Hausen, Heidelberg, FRG B. Sugden, Madison, WI R. C. Gallo, Bethesda, MD E. Schwarz, Heidelberg, FRG P. Tiollais, Paris, France VIRAL DNA IN HUMAN TUMORS G. Barbanti-Brodano, Ferrara, Italy VIRUSES WITH INITIATOR-LIKE FUNCTIONS G. Orth, Paris, France AND VIRUSES ACTING AS ANTICARCINOGENS E-M. de Villiers, Heidelberg, FRG J. Rommelaere, Brussels, Belgium K. Koike, Tokyo, Japan R. Heilbronn, Heidelberg, FRG 0. Yalkinoglu, Heidelberg, FRG VIRUS-HOST CELL INTERACTIONS IN E. Winocours, Rehovot, Israel ONCOGENESIS G. Miller, New Haven, CT IMMUNOLOGICAL CONTROL OF DNA TUMOR F. Wettstein, Los Afigeles, CA VIRUS INFECTION AND ONCOGENESIS F. V. Chisari, La Jolla, CA G. Klein, Stockholm, Sweden D. Lowy, Bethesda, MD A. Rickinson, Birmingham, UK S. Jablonska, Warsaw, Poland L. Gissmann, Heidelberg, FRG

INFORMATION AND APPLICATION FORMS American Association for Cancer Research Temple University School of Medicine (after October 1, 1988) West Building, Room 301, Philadelphia, PA 19140 530 Walnut Street, 10th Floor 215-221-4565 215-221-2688 (FAX) Philadelphia, PA 19106 Attendance is limited; applications will be accepted on a first-come, first-served basis. DEADLINE FOR REDUCED REGISTRATION FEE: OCTOBER 14, 1988 ADVANCE REGISTRATION ENDS: DECEMBER 5, 1988