Saurashtra University Re – Accredited Grade ‘B’ by NAAC (CGPA 2.93) Pandya, Nilay U., 2010, “Synthesis and Pharmacological Study of some New Chemical Entities”, thesis PhD, Saurashtra University http://etheses.saurashtrauniversity.edu/id/eprint/434 Copyright and moral rights for this thesis are retained by the author A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the Author. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the Author When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given. Saurashtra University Theses Service http://etheses.saurashtrauniversity.edu [email protected] © The Author “Synthesis and pharmacological Study of some New Chemical Entities” A THESIS SUBMITTED TO THE SAURASHTRA UNIVERSITY IN THE FACULTY OF SCIENCE FOR THE DEGREE OF Doctor of Philosophy IN CHEMISTRY BY Nilay U. Pandya UNDER THE GUIDANCE OF PROF. ANAMIK SHAH DEPARTMENT OF CHEMISTRY (DST-FIST FUNDED AND UGC-SAP SPONSORED) SAURASHTRA UNIVERSITY RAJKOT – 360 005 GUJARAT (INDIA) APRIL- 2010 — ´O: xaiNtrNtir(a xaiNt: p<$vI xaiNtrap: xaiNtrO86ay: xaiNtvnSpty xaiNtivRXve deva: xaiNtb/R½a xaiNt: svR xaiNt: xaiNtrev xaiNt: sa ma xaiNtrei6 ˜ — xaiNt: xaiNt: xaiNt: — Namaste I bow down and honor the place in you, in which the entire universe dwells. I bow down and honor the place in you, which is of love, of truth, of light and of peace. When you are in that place inside you and I am in that place inside me, we are one. Dedicated With Lots of Love, Respect and Gratitude to… Mummy, Pappa, Anshul and Vijeta. -Nilay Statement under O. Ph. D. 7 of Saurashtra University The work included in the thesis is done by me under the supervision of Prof. Anamik K. Shah and the contribution made thereof is my own work. Date: Place: Nilay U. Pandya Certificate This is to certify that the present work submitted for the Ph.D. Degree of Saurashtra University by Mr. Nilay U. Pandya has been the result of work carried out under my supervision and is a good contribution in the field of organic, heterocyclic and synthetic medicinal chemistry. Date: Place: Prof. Anamik K. Shah ACKNOWLEDGEMENT It is a moment of gratification and pride to look back with a sense of contentment at the long traveled path, to be able to recapture some of the fine moments, to be thankful to several people, some who were with me from the beginning, some who joined me at different stages during this journey, whose kindness, love and blessings, who in some way or the other have brought me to this day. I wish to thank each and every one of them from the very bottom of my heart. Therefore, first and foremost I bow my head with sheer respect and convey my pleasant regards to my most adorable Mummy-Pappa, Mrs. Panna U. Pandya and Dr. Upendra H. Pandya without whom I would have been absolutely nothing. Whatever I am today and whatever I am capable of is only because of their unfailing blessings, never ending hard work and endless love. Although one can never repay the debt towards their parents, I take this small and humble opportunity to say that I love you and thank you for all that you people have done for me. I respect you for nurturing us with such great love, patience, hard work and instilling the best of Sanskaras in us. Anshul, my little brother has always been a pillar of support whenever I needed him the most. Although younger to me he has taught me a lot of things which are important in life. I thank him immensely from the bottom of my heart. No word in the dictionary would be able to express my gratitude towards my very beloved wife Dr. Vijeta (Verma) Pandya. As aptly said “Wives are always the better halves of the husbands” she has actually been that better half of me. I am indebted by her unconditional love, never ending support and unfaltering faith that she has shown in me during these days of my work and career. I would also like to thank her for all the expert support as well as for burning the mid night oil during this thesis writing. I sincerely admit that I could not have found a better life partner than her. I now bow my head with absolute respect and pleasantly convey my heartfelt thanks to my research guide and thesis supervisor, Prof. Anamik Shah, who has helped me at each and every stage of my tenure of research work with a lot of patience and enthusiasm. I am much indebted to him for his inspiring guidance, affection, generosity, love and everlasting supportive nature. The freedom he enjoys giving, made me think independently and efficiently in order to tackle multidisciplinary projects. If I could acquire 50% of his immense patience I would be a better person. I feel privileged to be closely associated with him and I sincerely thank him from the bottom of my heart for believing in me and my capabilities. Thank You very much Sir. At this juncture, I thank my whole family for encouraging me and providing emotional support at each and every stage to fulfill this task. I would also like to convey my pleasant regards and thankfulness to my Baa and Dadaji, Deepu kaka, Harsha Kaki, Kruti, Nikki, Mota Faiba, Shobha Faiba, Amit Bhai, Kinnar, Rakhee ben, Apurva Jijaji. It would have been a difficult task for me to settle in Rajkot if it were not for my maternal family. I bow my head with respect to my Naniji (Rajkot Baa), Asit mama, Meera mami, Bharat Mama, Chetna mami, Meet and Maitree. A very special mention and my heart full of gratitude and respect also goes towards my dearest Riddhi masi as well as the ever smiling and ever encouraging Ketan Masa, whose blessings have always been our strength and I thank GOD that I have another set of parents who love me, if not equally, but as much as my own parents. I would also like to thank my brother Karn for being there besides me always whenever I needed him and my small little Mauli whose smile has always been like a ray of sunshine amidst the clouds. I’ am truly lucky to have you guys around. I am also indebted towards my Father in Law Mr. Raj Kumar Verma (Papa) for being so kind, helpful and patient with me during this tenure of my career. I would never be able to thank him enough for, he has put faith in me when no father would have dared to put faith in a situation like mine. Thank you Papa, may GOD give me the strength to fulfill your faith in me. I would also like to thank my Sister in law, Priyanka for providing me with reasons to smile and laugh and joke which I needed often. I also bow my head with respect and gratitude towards Babu (Grand father in law) as well as Choti Mummy (Grand mother in law) who have showered love, support and blessings all through out my tenure here. I also Thank my Chacha, Chachi and Preeti for being just like a family and supporting us all through. Sant Kabir had once aptly said “if I have to choose between GURU and GOVIND I will undoubtedly choose my GURU by whose kind blessings I have attained the power of knowledge and freedom”. At this occasion I very humbly bow my head with utter respect and gratitude to all my teachers who at every stage have shaped my life and given me the power of knowledge. Since I cannot write all the names of my teachers I very specially would like to mention a few teachers who have left an unfailing mark over me. With all due respect and gratitude I would humbly like to thank Dr. Urvish Pandya (my Urvish Bhai), as well as Dr. Shashi Pandya (Bhabhi) who apart from being my family members have also been excellent teachers and torch bearers of Chemistry. Hardly would one come across a teacher of the caliber of Prof. Deepak Rawal (Deepak mama), I was lucky that I got a chance to learn the ropes of this science from him, I am obliged to have him as my teacher. These three people have together laid a strong foundation on which I am going to build my career. I can never thank them enough. If they have laid the foundation Dr. Nishith Desai (Nishith Sir) as well as Ms. Ela Desai (Ela Miss) have put the first bricks into that foundation of chemistry. I thank them both for being so kind to share their knowledge with me and helping me in shaping my future. I would also like to thank Miss Saroj for being such an excellent teacher. I am totally indebted to two Sisters from different cities. Firstly I would like to thank Sr. Fatima (Bhavnagar), who taught us so many important things in life that I still remember them. The power of prayer, the power of faith and the importance of smile are all gifts of this kind lady. Nonetheless, I am also indebted to Sr. Jancy (Rajkot), who has revealed me the power of selfless love and service. Her one single opinion was enough to change my whole life without which it would have been totally different.