Corporate Information / Stock Information As of March 31, 2015

Corporate Headquarters Santen Pharmaceutical Co., Ltd. Composition of Shareholders Grand Front Tower A, By number of shares By number of shareholders 4-20 Ofuka-cho, Kita-ku, Osaka 530-8552, Individual 0.0% 0.6% Financial institutions investors Treasury stock 0.0% 0.3% Treasury stock URL: http://www.santen.com 9.0 Securities firms TEL: +81-6-6321-7000 (Main) % 1.1% 36.4% Other institutions +81-6-4802-9360 (PR and IR) Financial 4.2% institutions E-MAIL: [email protected] 44.0% Foreign investors Foreign 93.8% Individual Established 1890 investors 1.1% investors 9.5% Paid-in Capital ¥7,383 million Securities firms Other institutions Number of Shareholders 11,368 Major Shareholders Stock Exchange Listings Tokyo Number of Percentage of Ticker Code 4536 Name shares held ownership Thousands Transfer Agent Osaka Corporate Agency Division, State Street Bank and Trust Company 505223 5,709of shares 6.9% Mitsubishi UFJ Trust and Banking Corporation Japan Trustee Service Bank, Ltd. 5,587 6.8 6-3, Fushimi-cho 3-chome, Chuo-ku, The Master Trust Bank of Japan, Ltd. 3,432 4.2 Osaka 541-8502, Japan Development Bank of Japan Inc. 3,310 4.0 Nippon Life Insurance Company 2,132 2.6 Major Offices Sendai, Tokyo, Nagoya, Osaka and Fukuoka The Bank of Tokyo-Mitsubishi UFJ, Ltd. 2,121 2.6 Manufacturing Plants Noto and Shiga Ono Pharmaceutical Co., Ltd. 1,861 2.3 Daiichi Sankyo Company, Ltd. 1,836 2.2 Research Laboratory Nara Research and Development Center National Mutual Insurance Federation of Number of Employees 3,230 (non-consolidated: 1,899) Agricultural Cooperatives 1,438 1.7 Number of Shares Issued 82,653,103 Trust & Custody Services Bank, Ltd. as trustee for Eisai Company, Limited Retirement Benefit Trust Account re-entrusted by Mizuho Trust and Banking Co., Ltd 1,373 1.7

Stock Price Range (Yen) Monthly basis

2,000

1,500

TOPIX (Tokyo stock price index) 1,000

500

0 2010/4 2011/4 2012/4 2013/4 2014/4 2015/4 (Year/Month)

Trading Volume (Thousands of shares) Monthly basis

48,000

36,000

24,000

12,000

0 2010/4 2011/4 2012/4 2013/4 2014/4 2015/4 (Year/Month)

Yearly High and Low Prices

2011 2012 2013 2014 2015 High (yen) 689 731 1,010 1,230 1,892 Low (yen) 546.2 555.6 666 813 1,262

Notes 1: Calendar years. 2: Stock prices for 2015 are for the period to the end of June. 3: Stock price and trading volume from July 16, 2013 are those listed on the ; prior to this date are those listed on the Osaka Securities Exchange. 4. Santen conducted a 5-for-1 stock split of ordinary shares on the effective date of April 1, 2015. Figures for stock price and trading volume from before the stock split have been adjusted using the stock split ratio.

SantenSanten Pharmaceutical Pharmaceutical Co., Co., Ltd. Ltd. Annual Annual ReportReport 2015 113113 Business Bases As of August 2015

Corporate Headquarters and Subsidiaries Location

Corporate Headquarters Japan

Claire Co., Ltd. Japan

Santen Holdings U.S. Inc. U.S.A.

Santen Inc. U.S.A.

Advanced Vision Science, Inc. U.S.A.

Santen Holdings EU B.V.

Santen Oy

Santen S.A.S.

Santen GmbH

SantenPharma AB

Santen SA Switzerland

Santen S.r.l. Italy

Santen UK Limited U.K.

Santen Pharmaceutical , S.L. Spain

Santen Pharmaceutical () Co., Ltd. China

Santen Pharmaceutical Sales & Marketing (Suzhou) Co., Ltd. China

Santen Pharmaceutical Korea Co., Ltd. Korea

Taiwan Santen Pharmaceutical Co., Ltd.

Santen Private Limited India

Santen Pharmaceutical Asia Pte. Ltd.

SANTEN () CO., LTD. Thailand

SANTEN PHARMA SDN. BHD. Malaysia

SANTEN INC. Philippines

Other Office

Beijing Representative Office (China) Ho Chi Minh City Representative Office (Vietnam)

114 Santen Pharmaceutical Co., Ltd. Annual Report 2015 Plants and Laboratories

Noto Plant (Japan) Shiga Product Supply Center (Japan) Tampere Plant (Finland)

Suzhou Plant (China) Nara Research and Development Center (Japan)

Santen Pharmaceutical Co., Ltd. Annual Report 2015 115