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Cervical Cancer (Borja Otero) LiFE Literature for ENYGO Issue No 1, October 2015 Kristina Lindemann Kamil Zalewski Michael J. Halaska ENYGO EEG with support of ESGO www.esgo.org CONTENT LiFE Literature for ENYGO Content Ovarian cancer Screening for ovarian and fallopian tube cancer (Lucas Minig) .................................................................................................................................3 Hereditary ovarian cancer (BRCA1/2 mutation, genetic counseling, management) (Sara Giovannoni) ...................................................................4 Surgical treatment of recurrent ovarian cancer (Patriciu Achimas-Cadariu) ............................................................................................................6 Medical treatment of recurrent ovarian cancer (Elisabeth Chereau) ........................................................................................................................8 Treatment of ovarian tumors of low malignant potential (borderline ovarian tumors) (Ignacio Zapardiel) ...............................................................9 Emerging molecular-targeted therapies or early preclinical trials in ovarian cancer (Muhammed Rizki Yaznil) ......................................................10 Endometrial cancer Treatment of endometrial hyperplasia (biology, conservative and definitive treatment, follow-up) (Kastriot Dallaku and Elko Gliozheni) ...................12 Pathology in endometrial cancer (prognostic factors, EIN, EIC) (Santiago Scasso) ...................................................................................................15 Medical (chemo- and radiotherapy) treatment of primary uterine cancer (David Lindquist) .....................................................................................17 Surgical treatment of primary uterine cancer (Piotr Lepka) .......................................................................................................................................18 Surgical treatment of recurrent uterine cancer (Arun Kalpdev) .................................................................................................................................20 Medical (chemo and radiotherapy) treatment of recurrent uterine cancer (Ewa Surynt) ..........................................................................................21 Emerging molecular-targeted therapies or early preclinical trials in endometrial cancer (Ines Vasconcelos) ..........................................................23 Cervical cancer Cervical pre-invasive disease (diagnosis, management, follow-up) (Geanina Dragnea) ...........................................................................................24 Pathology of cervical cancer (Borja Otero)..................................................................................................................................................................26 Surgical treatment of primary cervical cancer (Matteo Morotti and Aljosa Mandic) ................................................................................................28 Medical treatment of primary and recurrent cervical cancer (Kristina Lindemann) .................................................................................................30 Vulvar cancer Preinvasive disease of vulva and vagina (etiology, diagnosis, management, follow-up) (Kamil Zalewski) ..............................................................32 Pathology of epithelial and non-epithelial malignant tumours of the vulva and vagina (Kamil Zalewski) ...............................................................33 Treatment of recurrent vulvar cancer (Maria de los Reyes Oliver) .............................................................................................................................34 Surgical management Minimal invasive surgery in gynaecological cancer (laparoscopy, robotics) (Marc Barahona Orpinell) ....................................................................36 Prevention and management of complications in surgical treatment of gyneacological malignancies (ie lymphocele, urological, wound, etc) (Elisa Piovano)..............................................................................................................................................39 Sentinel node mapping in gynaecological malignancies (Anton Ilin).........................................................................................................................41 Miscellaneous Fertility sparing treatment in gynecological malignancies (Dimitris Papatheodorou) ...............................................................................................43 Treatment of elderly patients with gynaecological cancers (Alex Mutombo) ............................................................................................................45 Nutritional support/status in gynaecological cancer (Jiri Presl) ...............................................................................................................................47 Follow-up after gyneacological malignancies (Anne van Altena) ..............................................................................................................................48 Gestational trophoblastic disease management (pathology, diagnosis, follow-up, pregnancies) (Manuela Undurraga) .........................................50 Quality of life in gynaecological cancers/Palliative care (Stef Cosyns) .....................................................................................................................52 Immunotherapy in gynaecological cancers (Zoltan Novak) ........................................................................................................................................54 Cancer in pregnancy (Michael J. Halaska) .................................................................................................................................................................55 List of contributors, acknowledgments.......................................................................................................................................................................56 www.esgo.org Page 2 « Back to Content OVARIAN CANCER LiFE Literature for ENYGO Screening for ovarian and fallopian tube cancer Editor Lucas Minig Descriptive summary The main publications regarding ovarian cancer screening include less mortality is under investigation. In this regard, should the UKC- a publication of the results of the United Kingdom Collaborative TOCS report a negative outcome, then other screening strategies Trial of Ovarian Cancer Screening (UKCTOCS). This is the largest will need to be considered and developed. published randomized trial where the combination of transvagina A sub-analysis of the same trial, demonstrated that sixteen percent ultrasound and CA-125, called multimodal strategy (MMS), was test- (3499/21,733) of women requiring a repeat screening test in addition ed in 46,237 women older than 50 years. MMS was compared with to annual screen withdrew from the study: 12.9% (1560/12,073) pelvic ultrasound or no screening, and a specific algorithm (ROCA) from the multimodal group and 20.1% (1939/9660) from the US established the risk of ovarian cancer. Thus, annual screening was group. An estimated relative risk of withdrawal is 1.46 (95% offered to women with normal ROCA value; CA-125 was repeated confidence interval, 1.36-1.56; P<0.001) for the US arm. High anxiety 12-weeks later in women with intermediate risk; and a second MMS trait and increased psychological morbidity significantly influenced was done 6 weeks later in case of high risk. If high risk persisted, withdrawal, even when age, screening center, and group were taken women were clinically evaluated. Specificity was lower for ultra- into account (P< 0.001). sound compared to MMS, resulting in nine times as many surgeries performed in the ultrasound group to detect one cancer. MMS had Cancer precursor lesions in the BRCA population at the time of a sensitivity and specificity to detect ovarian cancer of 85.8% (95% prophylactic salpingo-oophorectomy are another potential surrogate CI, 79.3% to 90.9%) and 99.8% (95% CI, 99.8% to 99.8%), respec- marker for ovarian cancer prevention. As Lheureux L et al. states in tively, with 4.8 surgeries per ovarian cancer diagnosed. Of the 155 an interesting clinical commentary, the most reproducible interpre- women with ovarian cancer, ROCA detected 86.4%, whereas using tation and optimal identification of carcinomas and precursor lesions annual serum CA-125 fixed cut-offs of more than 35, more than 30, from samples obtained from women who have undergone risk and more than 22 U/mL would have identified only 41.3%, 48.4%, reduction salpingo-oophorectomy with germline BRCA1/2 mutations and 66.5%, respectively. The area under the curve for ROCA was require comprehensive processing (SEE-FIM) alongside the use of significantly higher than that for a single-threshold rule (0.869 versus a validated diagnostic algorithm that combines histologic features 0.915; p=0.0027). Therefore, CA-125 rise within normal range can (routine H&E morphological assessment) and immunohistochemical be detected by ROCA long before any abnormality is detected with expression of p53 and Ki-67. Future large and prospective preventive trans-svaginal ultrasound. However, whether this is associated with trial in HGSOC, should consider these aspects. Relevant articles retrieved May-Aug 2015 No Title Authors Journal Link
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