Anti-TEP1 (N-Terminal) Polyclonal Antibody (DPABH-16917) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use
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Anti-TEP1 (N-terminal) polyclonal antibody (DPABH-16917) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase- associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist. Immunogen A 20 amino acid synthetic peptide from near the amino terminus of Human TEP1. Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Rat, Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, IHC-P Format Liquid Size 50 μg Buffer Constituents: PBS Preservative 0.02% Sodium Azide Storage Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name TEP1 telomerase-associated protein 1 [ Homo sapiens ] Official Symbol TEP1 Synonyms TEP1; telomerase-associated protein 1; telomerase protein component 1; p240; TLP1; TP1; TROVE domain family; member 1; TROVE1; VAULT2; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1; Entrez Gene ID 7011 Protein Refseq NP_009041 UniProt ID Q99973 Chromosome Location 14q11.2 Function ATP binding; RNA binding; nucleotide binding; contributes_to telomerase activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.