Anti-TEP1 (N-Terminal) Polyclonal Antibody (DPABH-16917) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-TEP1 (N-terminal) polyclonal antibody (DPABH-16917) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase- associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Immunogen A 20 amino acid synthetic peptide from near the amino terminus of Human TEP1.

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, IHC-P

Format Liquid

Size 50 μg

Buffer Constituents: PBS

Preservative 0.02% Sodium Azide

Storage Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol TEP1

Synonyms TEP1; telomerase-associated protein 1; telomerase protein component 1; p240; TLP1; TP1; TROVE domain family; member 1; TROVE1; VAULT2; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1;

Entrez Gene ID 7011

Protein Refseq NP_009041

UniProt ID Q99973

Chromosome Location 14q11.2

Function ATP binding; RNA binding; nucleotide binding; contributes_to telomerase activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]