The Journalof

VOLUME263 PHARMACOLOGY 1992 AND EXPERIMENTAL THERAPEUTICS

Contents

ANALGESICS Hemodynamic Effects of GI 87084B, an Ultra-Short Acting Michael K. James, Alain Vuong, 84 Mu-Opioid Analgesic, in Anesthetized Dogs Mary K. Grizzle, Suzanne V. Schuster and Joel E. Shaffer Antinociceptive Actions of Spinal Nonsteroidal Anti- Annika B. Malmberg and Tony L. Yaksh 136 Inflammatory Agents on the Formalin Test in the Rat

Modulation of Mu-Mediated Antinociception in the Mouse F. Porreca, A. E. Takemori, M. Sultana, 147 Downloaded from Involves Opioid Delta-2 Receptors P. S. Portoghese, W. D. Bowen and H. I. Mosberg Involvement of Supraspinal and Opioid Receptors in Jimmy Y. Xu, James M. Fujimoto and 246 Inhibition of the Tail-Flick Response Induced by Etorphine in Leon F. Tseng the Mouse

Isobolographic and Dose-Response Analyses of the Annika B. Malmberg and Tony L. Yaksh 264 jpet.aspetjournals.org Interaction Between Intrathecal Mu and Delta Agonists: Effects of Naltrindole and Its Benzofuran Analog (NTB) Chronic Cocaine Treatment Suppresses Basal Expression of Ratan V. Bhat, Andrew J. Cole and 343 zif268 in Rat Forebrain: In Situ Hybridization Studies Jay M. Baraban AUTONOMIC PHARMACOLOGY Nicotinic Receptor-Evoked Release of Acetylcholine and Toku Takahashi, Yasuhiro Tsunoda, 1 at ASPET Journals on September 28, 2021 Somatostatin in the Myenteric Plexus is Coupled to Calcium Yuanxu Lu, John Wiley and Influx via N-Type Calcium Channels Chung Owyang Serotonin-Induced Relaxation in Canine Coronary Artery Daniel J. Cushing and Marlene L. Cohen 123 Smooth Muscle Characterization of [3H1YM617, R4-)-5-2-(2[Ethoxyring(n)- Hidenori Yazawa, Masahiro Takanashi, 201 3H1 (o-ethoxyphenoxy)ethylJamino-propyl-2- Katsumi Sudoh, Osamu Inagaki and methoxybenzenesulfonamide HO, a Potent and Selective Kazuo Honda Alpha4 Adrenoceptor Radioligand Selective Inhibitory Effects of Calcium Channel Antagonists Fumiaki Hata, Akikazu Fujita, 214 on the Two Components of the Neurogenic Response of Kazuko Saeki, Isao Kishi, Guinea Pig Vas Deferens Tadayoshi Takeuchi and Osamu Yagasaki Evidence that S-Nitrosothiols are Responsible for the Smooth Steven W. Kerr, Lewis V. Buchanan, 285 Muscle Relaxing Activity of the Bovine Retractor Penis Stuart Bunting and W. Rodney Mathews Inhibitory Factor The Role of Adrenergic Receptors in the Initiation of I. M. Lang and S. K. Sarna 395 Vomiting and Its Gastrointestinal Motor Correlates

BEHAVIORAL PHARMACOLOGY The Discriminative Stimulus Effects of Clozapine in Pigeons: Eric M. Hoenicke, Susan A. Vanecek 276 Involvement of 5-Hydroxytryptamine, and 5- and James H. Woods Hydroxytryptamine2 Receptors Tolerance and Cross-Tolerance to the Activating Effects of Clifton W. Callaway and Mark A. Geyer 318 3,4-Methylenedioxymethamphetamine and a 5- Hydroxytryptamine,5 Agonist

CARDIOVASCULAR PHARMACOLOGY Inhibition of Human Cardiac Cyclic AMP- Didier de Chaffoy de Courcelles, 6 Phosphodiesterases by R 80 122, a New Selective Cyclic Katrien de Loore, Eddy Freyne and AMP-Phosphodiesterase III Inhibitor: A Comparison with Paul A. J. Janssen Other Cardiotonic Compounds

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Flavonoid Potentiation of Contractile Responses in Rat Blood Morris E. Berger, Michael S. Golub, 78 Vessels Chwen-Tzuei Chang, Jawad A. Al-Kharouf, Michael D. Nyby, Mark Hori, Arnold S. Brickman and Michael L. Tuck Carvedilol, a New Vasodilator and Beta Adrenoceptor Tian-Li Yue, Hung-Yuan Cheng, 92 Antagonist, is an Antioxidant and Free Radical Scavenger Paul G. Lysko, Patrick J. McKenna, Ron Feuerstein, Juan-Li Gu, Kathryn A. Lysko, Louisa L. Davis and Giora Feuerstein

A Comparison of the Potency of Selective L-Calcium Channel Th#{234}ophileGodfraind, Chantal Dessy and 112 Blockers In Human Coronary and Internal Mammary Arteries Salvatore Salomone Exposed to Serotonin Aldose Reductase and Myo-Inositol in Endothelial Cell Belay Tesfamariam, Michael L. Brown 153 Dysfunction Caused by Elevated Glucose and Richard A. Cohen Enhanced Blood Pressure and Renal Hemodynamic Effect of All F. Hajj-ali and Ben G. Zimmerman 158 Chronic vs. Acute Usinopril Administration in the Rabbit Downloaded from Cardiac Effects of 3,5-Dliodothyropropionic Acid, a Thyroid Gregory D. Pennock, Thomas E. Raya, 163 Joseph J. Bahi, Steven Goldman and Hormone Analog with Inotropic Selectivity Eugene Morkin Methylene Blue Inhibits Nitrovasodilator- and Endothelium- Nandor Marczin, Una S. Ryan and 170 Derived Relaxing Factor-Induced Cyclic GMP Accumulation John D. Catravas in Cultured Pulmonary Arterial Smooth Muscle CeUs via jpet.aspetjournals.org Generation of Superoxide Anion

CELLULAR AND MOLECULAR PHARMACOLOGY Effect of Ambasilide, a New Class III Agent, on Plateau Zhi-Hao Zhang, Christopher H. Foilmer, 40 Currents in Isolated Guinea Pig Ventricular Myocytes: Block Jonnalagedda S. M. Sarma, Fuhua Chen of Delayed Outward Potassium Currents and Bramah N. Singh

Imipramine’s Selective Suppression of an L-Type Calcium Jay J. Choi, Guo-Jie Huang, 49 at ASPET Journals on September 28, 2021 Channel in Neurons of Murine Dorsal Root Ganglia Involves Elizabeth Shafik, Wen-Hsien Wu and C Proteins Joseph J. McArdle Effects of ft-Endorphin on Mu and Delta Opioid Receptor- Dana E. Selley and Jean M. Bidlack 99 Coupled C-Protein ActivIty Low-K GTPase Studies On the Mechanism of Papaverine Inhibition of the Voltage- Man Iguchi, Toshiaki Nakajima, 194 Dependent Ca Current in Isolated Smooth Muscle Cells Tetsuya Hisada, Tsuneaki Sugimoto and from the Guinea Pig Trachea Yoshihisa Kurachi Block of Voltage-Gated Potassium Currents by Yu Zhu, Haesook K. Im and 207 Anticonvulsant U-54494A In Mouse Neuroblastoma Cells Wha Bin Im Specific Inhibition of Isoproterenol-Stimulated Cyclic AMP Michael T. Griffin and 221 Accumulation by M2 MuscarinIc Receptors in Rat Intestinal Frederick J. Ehiert Smooth Muscle Characterization of 1’IIAcidic Fibroblast Growth Factor Michael F. Jarvis, George W. Gessner, 253 Binding to the Cloned Human Fibroblast Growth Factor Gregory E. Martin, Michael Jaye, Receptor, FGF-flg, on NIH 3T3 Cell Membranes: Inhibitory Mark W. Ravera and Craig A. Dionne Effects of Heparin, Pertussis Toxin and Guanine Nucleotides Neuromedin B Binds with High Affinity, Elevates Cytosolic Terry W. Moody, Julie Staley, Farah Zia, 311 Calcium and Stimulates the Growth of Small-Cell Lung David H. Coy and Robert T. Jensen Cancer Cell Lines

CHEMOTHERAPY Tamoxifen-Reslstant Human Breast Cancer Cell Growth: Jeannine S. Strobl and 186 Inhibition by Thioridazine, Pimozide and the Calmodulin Virginia A. Peterson Antagonist, W-13

DRUG METABOLISM AND DISPOSITION Effects of Intrauterine Position on the Hepatic Microsomal Th. van der Hoeven, R. LeFevre and 32 Polysubstrate Monooxygenase and Cytosolic Glutathione 5- R. Mankes Transferase Activity, Plasma Sex Steroids and Relative Organ Weights in Adult Male and Female Long-Evans Rats

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Dose-Dependent Toxicokinetics of L-689,502, a Potent Jiunn H. Lin, 1-Wu Chen and 105 Human Immunodeficiency Virus Protease Inhibitor, in Rats Joyce King and Dogs Suppression of Hepatic Drug Metabolism by the Interferon Hirononi Sakai, Toshihiro Okamoto and 381 Yutaka Kikkawa Inducer, Polyriboinosinic Acid:Polyribocitidylic Acid

ENDOCRINE PHARMACOLOGY A Mechanistic Study on Enhancement of Rectal Permeability Akira Yamamoto, Eiji Hayakawa, 25 to Insulin in the Albino Rabbit Yasuki Kato, Akio Nishiura and Vincent H. L. Lee

GASTROINTESTINAL PHARMACOLOGY Prejunctional Muscarinic Receptors in the Deep Muscular Peter Kostka, Sultan Ahmad, 226 Plexus of Canine Ileum: Comparison with Smooth Muscle Chiu-Yin Kwan, Edwin E. Daniel, Receptors Richard K. Gordon and Peter K. Chiang Gastroprotective Effects of Thromboxane Receptor Martin L. Ogletree, Eugene H. O’Keefe, 374

Antagonists Stephen K. Durham, Bernard Rubin and Downloaded from Gunnar Aberg

NEUROPHARMACOLOGY Opioid Receptor Antagonists Discriminate between Anton N. M. Schoffelmeer, 20 Presynaptic Mu and Delta Receptors and the Adenylate Taco J. Dc Vries, Francois Hogenboom, Cyclase-Coupled Opioid Receptor Complex in the Brain Victor J. Hruby, Philip S. Portoghese and Anie H. Mulder jpet.aspetjournals.org Release of Endogenous Norepinephrine from Rat Patrizio Blandina, David Johnson, 61 Hypothalamus by Stimulation of N-Methyl-r-Aspartic Acid Janice Walcott and Joseph Goldfanb Receptors The Effect of the Atypical Antipsychotic Drug, Amperozide, Bryan K. Yamamoto and 180 on Carrier-Mediated Striatal Dopamine Release Measured in Herbert Y. Meltzer Vivo at ASPET Journals on September 28, 2021 Lack of Tolerance and Physical Dependence upon Repeated Ghislaine Perrault, Eliane Morel, 298 Treatment with the Novel Hypnotic Zolpidem David J. Sanger and Branimir Zivkovic S42-(4-Imidazolyl)ethylsothiourea, a Highly Specific and M. Garbang, J.-M. Arrang, A. Rouleau, 304 Potent Histamine H3 Receptor Agonist X. Ligneau, M. Dam Trung Tuong, J. C. Schwartz and C. R. Ganellin N-Methyl-i-Aspartic Acid (NMDA) and Non-NMDA Anna Pittaluga and Maunizio Raiteri 327 Receptors Regulating Hippocampal Norepinephrine Release. III. Changes in the NMDA Receptor Complex Induced by Their Functional Cooperation Comparison of 5-HydroxytryptaminelA-Mediated Sheryl G. Beck, Kue C. Choi and 350 Hyperpolarization in CAl and CA3 Hippocampal Pyramidal Troy J. List Cells Regulation of Cholecystokinin mRNA Content in Rat Xuan-Zhou Ding and halo Mocchetti 368 Striatum: A Glutamatergic Hypothesis PHARMACOLOGY OF SUBSTANCE ABUSE Membrane Potential in Myenteric Neurons Associated with Judith A. Leedham, Jian-Qiang Kong, 15 Tolerance and Dependence to Morphine David A. Taylor, Stephen M. Johnson and William W. Fleming Lipid Solubility of Sedative-Hypnotic Drugs Influences NancyEllen C. de Fiebre, 232 Hypothermic and Hypnotic Responses of Long-Sleep and Rodney J. Manley, Jeanne M. Wehner Short-Sleep Mice and Allan C. Collins

PULMONARY PHARMACOLOGY Pulmonary Accumulation of Propranolol in Vivo: Sites and Ralph E. Howell and Paul N. Lanken 130 Physiochemical Mechanism

RENAL PHARMACOLOGY Renal Organic Acid Transport: Uptake by Rat Kidney Slices Simon J. Henderson and 54 of a Furan Dicarboxylic Acid Which Inhibits Plasma Protein W. Edward Lindup Binding of Acidic Ligands in Uremia

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Pharmacological Profile of HS.-142-l, a Novel Nonpeptide Shoji Oda, Tomoyuki Sano, 241 Atrial Natriuretic Peptide (ANP) Antagonist of Microbial Yoshikazu Morishita and Origin. II. Restoration by HS-142-l of ANP-Induced Yuzunu Matsuda Inhibition of Aldosterone Production in Adrenal Glomerulosa Cells Gentamicin-Induced Hypercalciuria in the Rat: Assessment of Hugh 0. Garland, Donna J. Phipps and 293 Nephron Site Involved Ernest S. Harpur Effect of Thrombin on Proliferation, Contraction and Christine R. Albrightson, Ponnal Nambi, 404 Prostaglandin Production of Rat Glomerular Mesangial Cells Bodgan Zabko-Potapovich, In Culture George Dytko and Todd Groom

TOXICOLOGY Mechanism for the Hepatotoxicity of the Antiandrogen, Daniel Fau, Main Berson, 69 Nilutamide. Evidence Suggesting that Redox Cycling of this Dominique Eugene, Bernard Fromenty, Nitroaromatic Drug Leads to Oxidative Stress In Isolated Cecile Fisch and Dominique Pessayre Hepatocytes

In Vitro and in Vivo Biotransformation and Covalent Binding Zhuohan Hu and Peter G. Wells 334 Downloaded from of Benzo(a)pyrene in Gunn and RHA Rats with a Genetic Deficiency In Bilirubin Uridine Diphosphate- Glucuronosvltransferase Human Anti-Cytochrome P450 Antibodies in Aromatic J. Steven Leeder, Robert J. Riley, 360 Antlconvulsant-Induced Hypersensitivity Reactions Vicki A. Cook and Stephen P. Spielberg

Ca-Activated DNA Fragmentation and Sidhantha D. Ray, Christopher L. Sorge, 387 jpet.aspetjournals.org Dimethylnitrosamine-Induced Hepatic Necrosis: Effects of Lisa M. Kamendulis and Ca-Endonuclease and Poly(ADP-Ribose) Polymerase George B. Corcoran Inhibitors In Mice at ASPET Journals on September 28, 2021