(12) United States Patent (10) Patent No.: US 9,114,138 B2 Cid-Nunez Et Al
USOO9114138B2 (12) United States Patent (10) Patent No.: US 9,114,138 B2 Cid-Nunez et al. (45) Date of Patent: Aug. 25, 2015 (54) 1',3'-DISUBSTITUTED-4-PHENYL-3,4,5,6- (58) Field of Classification Search TETRAHYDRO-2H, 1'H-14' CPC .......................... A61K 31/4545; CO7D 401/04 BPYRIDINYL-2'-ONES USPC ........................................... 546/194; 514/318 (75) Inventors: Jose Maria Cid-Nunez, Toledo (ES); See application file for complete search history. Andres Avelino Trabanco-Suarez, (56) References Cited Toledo (ES); Gregor James MacDonald, Beerse (BE); Guillaume U.S. PATENT DOCUMENTS Albert Jacques Duvey, Geneva (CH): 4,051,244. A 9/1977 Mattioda et al. Robert Johannes Lutjens, Geneva 4,066,651 A 1/1978 Brittain et al. (CH); Terry Patrick Finn, Geneva (CH) (Continued) (73) Assignees: Janssen Pharmaceuticals, Inc., FOREIGN PATENT DOCUMENTS Titusville, NJ (US); Addex Pharma SA, BE 841390 11, 1976 Geneva (CH) CA 1019323 1Of 1977 (*) Notice: Subject to any disclaimer, the term of this (Continued) patent is extended or adjusted under 35 OTHER PUBLICATIONS U.S.C. 154(b) by 287 days. Adam, Octavian R. “Symptomatic Treatment of Huntington Dis (21) Appl. No.: 12/677,618 ease” Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics Apr. 2008, vol. 5, 181-197.* (22) PCT Filed: Sep. 12, 2008 Hook V. Y.H. “Neuroproteases in Peptide Neurotransmission and Neurodegenerative Diseases Applications to Drug Discovery (86). PCT No.: PCT/EP2008/007551 Research” Biodrugs 2006, 20, 105-119.* 371 1 Conn, P.J. “Activation of metabotropic glutamate receptors as a novel S (c)(1), approach for the treatment of schizophrenia.” Trends in Pharmaco (2), (4) Date: Jun.
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