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Annual Report 2011.Pdf Annual Report 2011 DEPARTMENT OF MEDICAL RESEARCH i Annual Report 2011 ision of the Department of Medical Research (Lower Myanmar) ♦ Achieving a healthier nation through application of research findings ims of the Department of Medical Research (Lower Myanmar) 1. To undertake research that contributes to the improvement of the health of the people of Myanmar 2. To conduct research utilizing new scientific knowledge and technologies in solving health problems of Myanmar 3. To improve scientific knowledge in the country by capacity building of resources, introducing new technologies, providing research training and by promoting research culture in academic institutions 4. To contribute towards socioeconomic development of the country through appropriate medical research ission Statement of the Department of Medical Research (Lower Myanmar) ♦ To develop and promote solutions to the major health problems of Myanmar ii Annual Report 2011 issions of the Department of Medical Research (Lower Myanmar) Mission Number 1 To investigate communicable diseases with emphasis on emerging and re-emerging diseases affecting health of the people Mission Number 2 To investigate non-communicable diseases affecting National Health Mission Number 3 To investigate nutritional factors and life style changes affecting health Mission Number 4 To strengthen research capacity through development of infrastructure and human resources, necessary for medical research Mission Number 5 To carry out health systems research highlighting effective and efficient health delivery systems including reproductive health Mission Number 6 To promote research on accidental, occupational, environmental and climatic factors affecting human health Mission Number 7 To carry out research on traditional medicine for safe and effective utilization within the existing health care system Mission Number 8 To promote research culture at medical and related health institutions and to provide academic and technical training for post graduate students Mission Number 9 To enhance technology development and analytical services applicable in the diagnosis, management and control of common diseases or conditions iii Annual Report 2011 FOREWORD The Annual Report for the Department of Medical Research (Lower Myanmar) covers the period April 2011 to March 2012. During the reporting period, genetic and amino acid sequencers were installed leading to a significant milestone in the development of research laboratories at the Department of Medical Research (Lower Myanmar). Moreover, establishment of new laboratories in collaboration with various funding agencies has been achieved; advanced molecular biology laboratory with the support of equipment by the Japanese International Co-operation Agency (JICA) Ex- participant Grant, and antivenom laboratory with the equipment donated under the Japan’s Grassroot Grant Assistance. Major cooperation with several International Agencies has been observed, especially with the Korean International Cooperation Agency (KOICA), and the International Atomic Energy Agency (IAEA). One of the major achievements during the year was the presentation of Emeritus Researcher Award to five distinguished reseachers and the celebration of the 48th Anniversary of the Department of Medical Research. This could be regarded as a major step in the preparation of the 50th Anniversary of the Department of Medical Research which will be in 2013. I also particularly support the service and collaboration provided by our scientists to the postgraduate students from the various universities. More than 50 masters and doctoral candidates are officially listed as post graduate students working together with DMR scientists in various disciplines of research to fulfil their research work. A Clinical Research Unit for Oral Medicine was also established, marking the collaboration with the University of Dental Medicine. Substantial increase in research collaboration with overseas universities both near and far was also observed. Another important milestone is the upgrading of the Institutional Ethical Review Board to the International Stage, having received recognitions and Fedearal Assurance Approval for the protection of human subjects from the Office of Human Research Protection, United States Department of Health and Human Services. I wish to praise the scientists and the staff for their utmost efforts in the conduct of the planned research activities during the reporting period and their consolidated efforts in drawing up of the 2011-2016, five-year Health Research Plan in line with the National Health Plan (2011-2016). I wish all the best for the coming year in the accomplishment of the research projects to attain our motto of “Fostering health and longevity through research”. Dr. Myo Khin Acting Director-General iv Annual Report 2011 BOARD OF DIRECTORS Dr. Myo Khin - Chairperson Dr. Ye Htut - Member Dr. San Shwe - Member Dr. Khin May Oo - Member Dr. Win Aung - Member Dr. Hlaing Myat Thu - Member Annual Report 2011 Dr. Myat Phone Kyaw - Member Department of Medical Research Dr. Ye Tint Lwin - Secretary (Lower Myanmar) PUBLISHED BY Department of Medical Research (LOWER MYANMAR) No.5, Ziwaka Road, Dagon P.O. Yangon 11191 v Annual Report 2011 CONTENTS Highlights of Research Findings viii Organization Profile xvi Department of Medical Research (Lower Myanmar) Layout Plan xvii Organizational Structure xviii Board of Directors xix Division Activities and Research Findings xx Bacteriology Research Division 1 Biochemistry Research Division 7 Biological Toxicology Research Division 10 Blood Programming Division 15 Blood Research Division 19 Chemical Toxicology Research Division 22 Clinical Research Division 26 Clinical Research Unit (Cerebral & Complicated Malaria - NOGH) 30 Clinical Research Unit (Haematology) 31 Clinical Research Unit (HIV / AIDS) 32 Clinical Research Unit (Malaria - Defence Services General Hospital, Mingaladon) 35 Clinical Research Unit (Malaria - No. 2 Military Hospital (500 bedded) Yangon) 37 Clinical Research Unit (Oncology) 39 Clinical Research Unit (Oral Medicine) 41 Clinical Research Unit (Snake Bite) 42 Clinical Research Unit (Toxicology) 43 Clinical Research Unit (Traditional Medicine) 44 Clinical Research Unit (University of Medicine - 2, Yangon) 47 Epidemiology Research Division 49 Experimental Medicine Research Division 55 Health Systems Research Division 59 Immunology Research Division 69 Medical Entomology Research Division 73 Medical Statistics Division 78 Nuclear Medicine Research Division 82 Nutrition Research Division 84 Parasitology Research Division 87 Pathology Research Division 93 Pharmaceutical Toxicology Research Division 97 Pharmacology Research Division 103 Physiology Research Division 109 Radiation Toxicology Research Division 113 Virology Research Division 115 Supporting Divisions Central Biomedical Library 120 Computer Division 123 Instrumentation Division 126 vi Annual Report 2011 Laboratory Animal Services Division 128 Publication Division 131 Administrative Department 134 General Administrative Division 134 Budget and Accounts Division 135 Stores and Procurement Division 135 Research Students 136 Consultants/Advisors to DMR (Lower Myanmar) 144 International Seminars/Workshops/Short Training Courses 146 International Fellowships and Training Courses 148 Local Seminars/Workshops/Short Training Courses 149 List of Publications 158 List of Papers Presented 164 Academic Activities of the Executive Board 172 Institutional Ethical Review Committee 176 DMR External Grant Reviewing Committee 176 Academic Committee 176 Scientific Talks in 2011 177 Protocols reviewed by the Protocol and Ethical Review Committee 177 Scientific Groups 180 Scientific Group on Malaria Research 180 Scientific Group on Traditional Medicine Research 180 Scientific Group on Snakebite Research 180 Scientific Group on HIV Research 180 Scientific Group on Liver and Gastrointestinal Diseases Research 181 Scientific Group on Growth and Nutrition Research 181 Scientific Group on Arboviral Diseases Research 181 Scientific Group on Nuclear Medicine Research 181 Scientific Group on Health and Social Medical Research 181 Scientific Group on Tuberculosis and Respiratory Diseases Research 182 Scientific Group on Poison Research 182 Scientific Group on Blood Research 182 Scientific Group on Information and Technology Research 182 Myanmar Health Sciences Research Journal Editorial Board 183 Department of Medical Research (LM) (Bulletin) Editorial Board 183 Department of Medical Research (LM) (E Newsletter) Editorial Committee 183 vii Annual Report 2011 HIGHLIGHTS OF RESEARCH FINDINGS HIV/AIDS Tuberculosis was still the most problematic opportunistic infection though unmasking effect of ART (antiretroviral therapy) in HIV-infected patients might be the cause of increased prevalence. At the end of 6 months follow up period, 83.6% (275/329) were survived, of whom 56.4% (155/275) received ART. A two-year prospective study in 280 HIV-infected patients at Specialist Hospital, Waibergi, Yangon revealed that immune reconstitution required sufficient time although ART has started. CD4 status before ART was found significantly associated with episodes of opportunistic infections during follow up period (Pearson chi-square, p=0.022). A significant correlation was also found between CD4 count and total lymphocyte count (Fisher’s Exact Test, p=0.0005). The existing situation of NGOs’ activities for HIV prevention and control at the township level in Dala and Thaketa townships revealed that most NGOs
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