Management of Anisometropic Amblyopia: a Case Report and Brief Review
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Management of fit with soft contact lenses to achieve optimal Anisometropic Amblyopia: vision and binocularity. Part-time occlusion therapy was also initiated, which was modified A Case Report and throughout the treatment period based on Brief Review clinical findings. She was also treated with Sung Hee (Kelly) Lee, OD, FAAO 19 sessions of office-based vision therapy in order to maximize the success of amblyopia Graham B. Erickson, OD, FAAO, treatment. At the completion of the treatment, FCOVD this patient showed significant improvement in her visual acuity and other non-acuity factors, including contrast sensitivity and binocularity. ABSTRACT Background Conclusions ARTICLE Unilateral functional amblyopia due The successful treatment of this patient with to anisometropia is a common cause anisometropic amblyopia was achieved by of vision loss in children. There has been a the combination of active vision therapy with significant amount of research recently to evidence-based management strategies, determine the most effective management consisting of optical correction and occlusion strategies for such cases, and it is important therapy. for clinicians to determine how to apply these findings clinically. INTRODUCTION Anisometropia is a common cause of Case Report functional amblyopia. It is often difficult to A 6-year-old female presented for her first detect without an effective vision screening or comprehensive eye exam after failing a school a comprehensive eye examination, as there are vision screening. She was diagnosed with typically no symptoms or obvious manifesting significant anisometropia with anisometropic signs. amblyopia in her left eye. She was treated with A generally accepted definition of aniso- spectacle correction initially, and was eventually metropia is at least 1D difference of sphere or cylinder power between each eye.1,2,3,4 The Correspondence regarding this article should be potential amblyogenic amount of anisometropia emailed to Sung Hee (Kelly) Lee, OD, FAAO, at is suggested to be 1D for hyperopia, 3D [email protected]. All state ments are the authors’ 5 personal opinions and may not reflect the opinions of for myopia, and 1.5D for astigmatism. The the College of Optometrists in Vision Development, reported incidence of amblyopia is 100% with Vision Development & Rehabilitation or any institution hyperopic anisometropia of 3.5D or higher, or organization to which the authors may be affiliated. Permission to use reprints of this article must be obtained and in myopic anisometropia of 6.5D or from the editor. Copyright 2019 College of Optometrists higher.1,2,6,7 in Vision Development. VDR is indexed in the Directory of Open Access Journals. Online access is available at In anisometropic amblyopia, visual depriv- covd.org. https://doi.org/10.31707/VDR2019.5.2.p100 ation and the subsequent lack of adequate retinal stimulus are caused by optical defocus Lee SHK, Erickson GB. Management of anisometropic amblyopia: A case report and brief review. Vision Dev & and abnormal binocular inhibition in the Rehab 2019;5(2):100-12. more ametropic eye.1,3,6,8,9 In addition to acuity loss, these mechanisms also affect the normal development of other vision factors Keywords: Amblyopia; Anisometropia; including contrast sensitivity, accommodation, Vision Therapy oculomotor function, and eye-hand coordina- 100 Vision Development & Rehabilitation Volume 5, Issue 2 • June 2019 tion.1,2,3,6,10 Another considerable factor is the no afferent pupillary defect in both eyes. The compromised binocularity in these patients. confrontation visual fields were grossly full, Even after improvement of vision and deficient and extraocular muscle motilities were full vision skills in the amblyopic eye, aniseikonia and unrestricted in each eye. Cover testing and binocular inhibition patterns can remain as revealed ortho alignment at distance and obstacles for obtaining sensory fusion without 6Δ exophoria at near. No stereo acuity was further intervention. reported with the Lang I stereoacuity test. The In addition to recognizing the risk factors following are the results of objective refraction: and clinical findings described above, the appropriate evidence-based management Dry Retinoscopy: strategies that should be considered for OD: +1.00D patients with anisometropic amblyopia include OS: +8.50-1.25x004 optical correction and occlusion. Further, active vision therapy (VT) should also be considered Wet Retinoscopy to potentially improve the efficacy and (1gtt 1% cyclopentolate OU): facilitate the efficiency of the treatment. This OD: +2.00D case report demonstrates an effective course OS: +9.00-1.00x175 of treatment for anisometropic amblyopia using all of these strategies. Anterior and posterior segment ocular health were unremarkable. CASE Based on the findings, AC was diagnosed AC, a 6-year-old female, presented for her with refractive amblyopia in the left eye first comprehensive eye exam after failing a secondary to high hyperopic anisometropia school vision screening. This first grader was of 6.5D (equivalent sphere). A spectacle told that her left eye was not “focusing” as correction was chosen over contact lenses since well as the right eye. Another optometrist protection of the sound eye was one of the at the clinic initiated the vision care of AC, treatment goals due to the severe amblyopia. before care was transferred to the authors. However, contact lenses to minimize anisei- AC’s mother reported no noticeable problems konia were strongly recommended as a future regarding her eyes or vision and AC never option as the amblyopia resolves. A spectacle reported any complaints. AC’s health history prescription of +1.00D OD and +8.00- was unremarkable and the pregnancy and 1.00x175 OS was provided for full time wear. birth histories were normal. She was meeting The importance of compliance with spectacle normal developmental milestones and not wear was emphasized and she was advised to experiencing any difficulties at school. She return to the clinic in 6 weeks for a follow-up reported an allergy to penicillin that causes evaluation of her prescription and amblyopia. a rash, and was taking no medication other than a multivitamin supplement. There was no Follow-Up Visit #1 known family history of any ocular conditions. AC’s mother reported good compliance with spectacle wear. The corrected distance Initial Exam visual acuities were 20/20 (1.0MAR) OD and AC’s uncorrected vision in the right eye 20/125- (6.3-MAR) OS with isolated single line was 20/20 (1.0MAR) at both distance and near; Snellen acuity. She demonstrated 400 arc however, the left eye was 20/250- (12.5-MAR) seconds of local stereo acuity with Wirt-type at distance and 20/200- (10.0-MAR) at near. circles on the Randot steroacuity test. The The pupils were equally reactive to light with over-retinoscopy findings through the current 101 Vision Development & Rehabilitation Volume 5, Issue 2 • June 2019 spectacles revealed +1.25D OD and +0.25- with the Snellen single line, 20/50 (2.0MAR) 0.25x180 OS. The prescription was not modified with single letter, and 20/60- (3.0- MAR) with at this time, and it was decided to monitor. crowded Lea symbols. She reported no global AC’s optometrists at this visit initiated 2 hours stereo with the Randot butterfly stereoacuity of daily patching of the right eye with a Patch- test and 100 arc seconds of local stereo with works eye patch to expedite the recovery of the animals on the Randot test. The 3-Figure visual acuity. AC was recommended to engage Worth test revealed suppression of the left eye in eye-hand coordination activities at near at distances farther than 1 meter. Visuoscopy while patching. A follow-up appointment was testing showed steady central fixation in the scheduled in 1 month. right eye and unsteady central fixation in the left eye. The clinical findings measured at Follow-Up Visit #2 this visit are summarized in Table 2. AC was AC still reported good compliance with recommended to attempt increasing patching spectacle wear. However, patching was to 2 hours a day while engaging in near eye- reported to be extremely difficult, and it could hand activities. The option of a contact lens only be done for about 30 minutes each day. correction was discussed again. AC’s mother The corrected distance visual acuity in the left was informed about the option of active vision eye improved to 20/80- (4.0-MAR) with Snellen therapy to potentially increase the efficacy of single line and 20/70 (3.5MAR) with Snellen occlusion therapy, decrease the treatment isolated letter. Over-retinoscopy results were duration, train the vision skill deficits in the consistent with the first follow-up visit, so the amblyopic eye, and maximize binocularity. right eye’s prescription was updated to +2.00D After the discussion, it was decided to pursue from +1.00D. The left eye’s prescription a contact lens correction and initiate a weekly remained unchanged. She was recommended vision therapy program. to try patching the right eye for 2 hours/ day, 7 days/week, and was educated on the Active Vision Therapy Program (28 weeks) importance of compliance with occlusion Active Vision Therapy therapy for maximum benefit. The next follow- Weekly 45-minute in-office vision therapy up visit was scheduled in 1 month. sessions were conducted, and AC’s visual acuity in her left eye was measured at Follow-Up Visits #3-5 each visit. In addition to daily patching, These follow-up visits were conducted in approximately 35 minutes of home therapy monthly intervals. AC had difficulty and poor was prescribed for 5 days each week. The compliance with the patching regimen of 2 compliance with in-office visits was good, with hours per day that was prescribed. For follow- moderate compliance with the prescribed up visits #3 and #4, minimal improvement home therapy activities. Progress evaluations of the VA in the left eye was measured.