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Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 Review on the Third International Neuroinflammation Congress and Student Fes tival of Neuroscience in Mashhad University of Medical Sciences 1 2 1, 3* Sayed Mos tafa Modarres Mousavi , Sajad Sahab Negah , Ali Gorji 1Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran 2Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran 3 Epilepsy Research Center, Department of Neurology and Neurosurgery, Wes tfälische Wilhelms-Universität Müns ter, Müns ter, Germany Article Info: Received: 11 June 2019 Revised: 12 June 2019 Accepted: 13 June 2019 ABSTRACT Introduction: Neuroinflammation congress was the third in a series of annual events aimed to facilitate the inves tigative and analytical discussions on a range of neuroinflammatory diseases. The neuroinflammation congress focused on various neuroinflammatory disorders, including multiple sclerosis, brain tumors, epilepsy, and neurodegenerative diseases. The conference was held in June 11-13, 2019 and organized by Mashhad University of Medical Sciences and Muns ter University, which aimed to shed light on the causes of neuroinflammatory diseases and uncover new treatment pathways. Conclusion: Through a comprehensive scientific program with a broad basic and clinical aspects, we discussed the basic aspects of neuroinflammation and neurodegeneration up to the s tate-of-the-art treatments. In this congress, 334 scientific topics were presented and discussed. Key words: 1. Nervous Sys tem Diseases 2. Inflammation Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] 3. Congress 4. Iran 5. Germany *Corresponding Author: Ali Gorji E-mail: gorjial@uni-muens ter.de 111 دوره هفتم، شماره سوم، تابستان 1398 مروری بر سومين همايش بين المللی التهاب سيستم عصبی و سومين فستيوال دانشجويی علوم اعصاب در دانشگاه علوم پزشکی مشهد سيد مصطفی مدرس موسوی1، سجاد سحاب نگاه2، علی گرجی3 ،1* 1مرکز تحقیقات علوم اعصاب شفا، بیمارستان خاتم اﻻنبیا، تهران، ایران 2گروه علوم اعصاب، دانشگاه علوم پزشکی مشهد، مشهد، ایران 3مرکز تحقیقات صرع، گروه نورولوژی و جراحی مغز و اعصاب، دانشگاه مونستر، مونستر، آلمان اطﻻعات مقاله: تاريخ دريافت: 21 خرداد 1398 اصﻻحيه: 22 خرداد 1398 تاريخ پذيرش: 23 خرداد 1398 چــــــــكيد ه مقدمه: همایش التهاب سیستم عصبي سومین سري از رویدادهاي ساﻻنه است که بررسي و تجزیه و تحلیل بحث طیف بیماري هاي التهاب عصبي را تسهیل مي کند. همایش التهاب سیستم عصبي بر روي اختﻻﻻت التهاب عصبي از قبیل مالتیپل اسکلروز، تومورهاي مغزي، صرع و اختﻻﻻت تحلیل برندة سیستم عصبي تمرکز دارد. همایش در 23-21 خرداد 1398 توسط دانشگاه علوم پزشکي مشهد و دانشگاه مونستر برگزار شد که هدف آن روشن ساختن علت بیماري هاي التهاب عصبي و کشف مسیرهاي جدید درمان بود. نتيجهگيري: ما در مورد جنبه هاي اصلي التهاب عصبي و بیماري هاي تحلیل برندة عصبي توسط یك برنامة علمي جامع با تمرکز بر وضعیت پایه و بالیني، تا مرحلة پیشرفتة درمان بحث کردیم. در این همایش 334 عنوان علمي ارائه و بحث گردید. كليد واژه ها: 1. بیماریهــای سیســتم عصبــی 2. التهاب [ Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 3. همایش 4. ایران 5. آلمان * نويسنده مسئول: علی گرجی آدرس الکترونيکي: gorjial@uni-muens ter.de 112112112 Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 مقدمه نتيجه گيری ایــن همایــش کــه توســط دانشــکده پزشــکی دانشــگاه علــوم در ایــن همایــش در دو بخــش ســخنرانی ها و پوســترها پزشــکی مشــهد و دانشــگاه مونســتر آلمــان برگــزار گردیــد، جنبه هــای مختلــف التهــاب در بیماری هــای عصبــی در بــه بررســی نقــش التهــاب در بیماریهــای سیســتم عصبــی گســتره علــوم پایــه و بالینــی توســط محققــان مختلفــی از مرکــزی از قبیــل مالتیپــل اســکلروز، صــرع، آنســفالیت مغــزی، کشــورهای ایــران و آلمــان مــورد بحــث و تبــادل نظــر قــرار تومورهــای مغــزی و بیماریهــای تحلیــل برنــده سیســتم گرفــت، کــه خﻻصــه مقــاﻻت آنهــا در ادامــه جهــت مطالعــة عصبــی میپــردازد. همچنیــن بــه نقــش ســلولهای بنیــادی، عﻻقه منــدان و بازگشــایی افقهــای جدیــد تحقیقاتــی و نانوتکنولــوژی و هنــر درمانــی در درمــان بیماریهــای سیســتم بالینــی پیــش روی پژوهشــگران علــوم اعصــاب آورده شــده عصبــی مرکــزی بــا زمینــه التهابــی پرداخته شــده اســت )7-1(. اســت. Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] 113 دوره هفتم، شماره سوم، تابستان 1398 The Neuroscience Journal of Shefaye Khatam Meeting Abstracts Open Access rd Abs tract Book of The 3 International Neuroinflammation rd Congress & The 3 Student Fes tival of Neuroscience 11-13 June, 2019, Mashhad, Iran. Oral Presentations O1 O2 Evaluation of Effects on Improvement of Muscle Cytotoxic T-Cells Cause Hippocampal Sclerosis in an Strength, Prevention of Oligodendrocytes and Myelin Animal Model of Autoimmune Limbic Encephalitis Damage in Brain, Animal Model of MS Disease Marco Gallus1*, Andre Dik1, Veno Narayanan1, Alireza Lotfi1, Nazem Ghasemi2, Zahra Abroodi2 Gordon Hicking1, Tobias Ruck1, ManuelaCerina1, Lydia Wachsmuth2, Cornelius Faber2, Sven G Meuth1, Department of Anatomical Sciences, Faculty of Medicine, Isfahan Nico Melzer1 University of Medical Sciences, Isfahan, Iran 1Institute of Translational Neurology, Department of Neurology, The Neuroscience Journal of Shefaye Khatam, 2019; 7(3): O1 University of Münster, Münster, Germany multiple sclerosis (MS) is a disorder with autoimmune 2Department of Radiology, University of Münster, Münster, pathophysiology which is accompanied by neurological Germany disability. Astaxanthin (AST) can be effective in The Neuroscience Journal of Shefaye Khatam, 2019; 7(3): O2 prevention of this abnormal conditions because of its ability to cross the blood brain barrier and the other Autoimmune limbic encephalitis (ALE) describes reasons are antioxidant and nerve protection effect. The group of autoimmune inflammatory syndromes, purpose of this study is to evaluate AST effect on MS often associated with cancer and characterized by prevention by appraising the muscle strength, prevention neurocognitive impairment, psychiatric symptoms like of oligodendrocyte cells and myelin degradation in Rat depression and mesial temporal lobe epilepsy. Magnetic brain. 4o wistar rats were divided into four experimental resonance imaging (MRI) initially shows an edema groups: control, cuprizone, sham (cuprizone + DMSO) with swelling and T2-signal increase of the amygdala and astaxanthin. AST group received cuprizone and hippocampus which subsequently may turn into (0.6%) and AST (3mg/Kg) coincidently for four hippocampal sclerosis with atrophy and persisting T2- weeks by gavaging. During the study we evaluate signal increase. In some patients autoantibodies against muscle strength by using a behavioral basket test, the intracellular neural antigens can be detected in serum percentage of cell expressing A2B5 and MOG markers and cerebrospinal fluid. In these cases, cytotoxic Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] by immunohistochemistry technique. Myelin density T cells (CTL) are thought to cause lysis of neurons was evaluated by luxal fast blue staining. We use RT which liberate intracellular antigens that trigger a B PCR in order to measuring MBP, MOG and PDGFr cell response with formation of autoantibodies. To gene expression. Using Image J and SPSS softwares,the better understand the pathophysiological mechanisms, results were analyzed by one-way ANOVA test. our data the goal of this study was to develop a CTL-mediated in immunochemistry and other evaluation techniques animal model of ALE. To that aim, we took advantage showed that the percentage of mature oligodendrocytes of the Combined Adjuvant for Synergistic Activation of and oligodendrocyte progenitor cells in the AST group Cellular immunity (CASAC) to induce a CTL-mediated were remarkable higher than those in the sham and answer against ovalbumin expressing hippocampal cuprizone group. In addition, myelin density and muscle CA1 neurons, created via stereotaxic injection of strength in AST group were higher than the those an adenovirus vector encoding for ovalbumin or cuprizone and sham group. (p≤0.05). this study confirms a control protein under the control of a synapsin the positive effects of AST and natural compounds promoter. Immunohistochemical staining showed containing AST in the prevention of oligodendrocytes infiltrations of CTLs in the hippocampus leading to and myelin ddestruction in the people susceptible to MS. astrocytosis, microglia activation and neuronal death. 114114114 Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 This corresponds to an antigen-dependent hippocampal Spatial learning and memory was evaluated using atrophy as demonstrated by MRI and memory Morris water maze test after the 11th PTZ injection. disturbance as revealed by the Novel Object Recognition Animals have received 13 injections of PTZ and then, Test in mice. Taken together, we demonstrate that CTL brain tissues were removed. Immunostaining against can cause hippocampal sclerosis in an animal model of NeuN and GFAP respectively as mature neuronal and ALE. astrocyte markers were performed on brain sections. High performance liquid chromatography (HPLC) was O3 performed to measure the ursin content in hippocampus. Art and Epilepsy Our results showed that ursin administration reduced the seizures behavior and prevented cognitive impairment Shaghayegh Gorji in fully kindled animals. The results of HPLC analysis Epilepsy Research
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    Molecules and Cells Minireview Transient Receptor Potential Channels and Metabolism Subash Dhakal and Youngseok Lee* Department of Bio and Fermentation Convergence Technology, Kookmin University, BK21 PLUS Project, Seoul 02707, Korea *Correspondence: [email protected] https://doi.org/10.14348/molcells.2019.0007 www.molcells.org Transient receptor potential (TRP) channels are nonselective Montell, 2007). These cationic channels were first charac- cationic channels, conserved among flies to humans. Most terized in the vinegar fly, Drosophila melanogaster. While TRP channels have well known functions in chemosensation, a visual mechanism using forward genetic screening was thermosensation, and mechanosensation. In addition to being studied, a mutant fly showed a transient response to being sensing environmental changes, many TRP channels constant light instead of the continuous electroretinogram are also internal sensors that help maintain homeostasis. response recorded in the wild type (Cosens and Manning, Recent improvements to analytical methods for genomics 1969). Therefore, the mutant was named as transient recep- and metabolomics allow us to investigate these channels tor potential (trp). In the beginning, researchers had spent in both mutant animals and humans. In this review, we two decades discovering the trp locus with the germ-line discuss three aspects of TRP channels, which are their role transformation of the genomic region (Montell and Rubin, in metabolism, their functional characteristics, and their 1989). Using a detailed structural permeation property anal- role in metabolic syndrome. First, we introduce each TRP ysis in light-induced current, the TRP channel was confirmed channel superfamily and their particular roles in metabolism. as a six transmembrane domain protein, bearing a structural Second, we provide evidence for which metabolites TRP resemblance to a calcium-permeable cation channel (Mon- channels affect, such as lipids or glucose.
  • 7Th World Congress on ADHD: from Child to Adult Disorder

    7Th World Congress on ADHD: from Child to Adult Disorder

    ADHD Atten Def Hyp Disord (2019) 11(Suppl 1):S1–S89 https://doi.org/10.1007/s12402-019-00295-7 ABSTRACTS Ó Springer-Verlag GmbH Austria, part of Springer Nature 2019 7th World Congress on ADHD: From Child to Adult Disorder 25th–28th April, Lisbon Portugal Editors: Manfred Gerlach, Wu¨rzburg Peter Riederer, Wu¨rzburg Andreas Warnke, Wu¨rzburg Luis Rohde, Porto Alegre 123 S2 ABSTRACTS Introduction Dear Colleagues and Friends, We are pleased to have received more than 180 poster abstracts as well as more than 100 poster abstracts from young scientists and clinicians (\ 35 years) who applied for our Young Scientists’ Award. Of all abstracts submitted by our young colleagues, the Scientific Programme Committee has selected the best eight. The authors have been invited to give a presentation as part of our two Young Scientist Award Sessions and to receive a prize money in the amount of 500 Euros. With this approach, we intend to highlight the importance of original scientific contributions, especially from our young colleagues. In this volume, the abstracts of our two Young Scientist Award Sessions come first, followed by regular poster abstracts. These have been organized by topics: Aetiology, Autism Spectrum Disorders, Co-morbidity, Diagnosis, Electrophysiology, Epidemiology, Experimental Models, Genetics, Neuroimaging, Non-pharmacological Treatment, Pathophysiology, Pharmacological Treatment, Quality of Life/Caregiver Burden, Substance Use Disorders and Miscellaneous. Submitted abstracts have not been modified in any way. Please, do not just read the selected poster abstracts, we also encourage you to actively discuss and share your ideas with our young colleagues. Finally, we would like thank all our speakers, contributors and sponsors of our 7th World Congress on ADHD: from Childhood to Adult Disease, and welcome you to join—what we are sure will be—a very enjoyable and highly informative event.
  • Download Product Insert (PDF)

    Download Product Insert (PDF)

    PRODUCT INFORMATION Terpene Screening Library Item No. 9003370 • Batch No. 0611615 Panels are routinely re-evaluated to include new catalog introductions as the research evolves. Page 1 of 4 Plate Well Contents Item Number 1 A1 Unused 1 A2 Ursolic Acid 10072 1 A3 Forskolin 11018 1 A4 Betulin 11041 1 A5 Lupeol 11215 1 A6 Paxilline 11345 1 A7 β-acetyl-Boswellic Acid 11674 1 A8 Andrographolide 11679 1 A9 Bakuchiol 11684 1 A10 Betulinic Acid 11686 1 A11 β-Elemonic Acid 11712 1 A12 Unused 1 B1 Unused 1 B2 Oleanolic Acid 11726 1 B3 Neoandrographolide 11742 1 B4 Asiatic Acid 11818 1 B5 Madecassic Acid 11854 1 B6 Cafestol 13999 1 B7 Ingenol 14031 1 B8 Bilobalide 14272 1 B9 (−)-Huperzine A 14620 1 B10 Ginkgolide B 14636 1 B11 Cucurbitacin B 14820 1 B12 Unused 1 C1 Unused 1 C2 Cucurbitacin E 14821 1 C3 Polygodial 14979 1 C4 Zerumbone 15400 1 C5 Ingenol-3-angelate 16207 1 C6 Ferutinin 16554 1 C7 Limonin 16932 1 C8 Phytol 17401 1 C9 Dehydrocostus lactone 18485 1 C10 β-Elemene 19641 1 C11 Juvenile Hormone III 19646 1 C12 Unused WARNING CAYMAN CHEMICAL THIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. 1180 EAST ELLSWORTH RD SAFETY DATA ANN ARBOR, MI 48108 · USA This material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly after handling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution.
  • (12) Patent Application Publication (10) Pub. No.: US 2015/0038576A1 Timokhina Et Al

    (12) Patent Application Publication (10) Pub. No.: US 2015/0038576A1 Timokhina Et Al

    US 20150.038576A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0038576A1 Timokhina et al. (43) Pub. Date: Feb. 5, 2015 (54) COMPOSITIONS AND THEIR USE FOR A24F 47/00 (2006.01) SMOKING CESSATION AND OTHER A63L/2 (2006.01) TREATMENTS A63L/II (2006.01) (71) Applicant: SENTIENS, LLC, Charlotte, NC (US) A6M I5/00 (2006.01) A63L/25 (2006.01) (72) Inventors: Inna S. Timokhina, Potomac, MD (US); A63L/343 (2006.01) Reid von Borstel, Potomac, MD (US); (52) U.S. Cl DennisMSG Tan, Weddington,NEW, NC 'S(US): CPCAV e. we............... A24B 15/16 (2013.01); A61 K3I/125 s s (2013.01); A61 K3I/05 (2013.01); A61 K (73) Assignee: SENTIENS, LLC, Charlotte, NC (US) 3 1/343 (2013.01); A61 K31/12 (2013.01); A6 IK3I/II (2013.01); A61M 15/009 (21) Appl. No.: 14/449,533 (2013.01); A24F 47/008 (2013.01) USPC ........... 514/470; 13 1/270; 13 1/273: 514/692; (22) Filed: Aug. 1, 2014 514/731: 514/678; 514/701: 128/200.14; 128/202.21 Related U.S. Application Data (60) Provisional application No. 61/861,865, filed on Aug. 2, 2013. (57) ABSTRACT Publication Classification A composition includes a liquid. The liquid aerosolizes for (51) Int. Cl. delivery to a user by an airway. The liquid includes an agent A24B 15/16 (2006.01) that activates a TRPV3 channel. The agent includes a terpe A6 IK3I/05 (2006.01) noid compound. Patent Application Publication Feb. 5, 2015 US 2015/0038576 A1 covC s US 2015/0038576 A1 Feb.
  • Camphor Elicits Up-Regulation of Hepatic and Pulmonary Pro

    Camphor Elicits Up-Regulation of Hepatic and Pulmonary Pro

    Pathophysiology 26 (2019) 305–313 Contents lists available at ScienceDirect Pathophysiology jo urnal homepage: www.elsevier.com/locate/pathophys Camphor elicits up-regulation of hepatic and pulmonary pro-inflammatory cytokines and chemokines via activation of NF-kB in rats a,∗ b a a Oluwatobi T. Somade , Babajide O. Ajayi , Nurudeen O. Tajudeen , Eniola M. Atunlute , a a Adewale S. James , Samuel A. Kehinde a Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria b Department of Biochemistry, Bowen University, Iwo, Nigeria a r t i c l e i n f o a b s t r a c t Article history: Consumption of camphor infusions is widely used as an aphrodisiac in preparation for sexual intercourse, Received 10 April 2019 to boost performance. There is dearth of information associating or relating its consumption to liver or Received in revised form 8 May 2019 lung inflammation. Therefore, we investigated the effect of various doses of camphor in an acute study, Accepted 28 July 2019 on hepatic and pulmonary levels of some pro-inflammatory cytokines and chemokines in male wistar rats. Following administration, 2000 and 4000 mg/kg body weight camphor significantly increase liver Keywords: and lung levels of tumor necrosis factor alpha (TNF-␣), interleukin 1 beta (IL-1␤) and interleukin 6 (IL-6) Camphor in a dose dependent manner compared with control, while interleukin 10 (IL-10) levels were significantly Chemokines Cytokines increased only by 1000 and 4000 mg/kg body weight camphor in liver and lung respectively, compared Hepatic with control. Also compared with control, camphor administration resulted in a significant increase in the Pro-inflammation expressions of hepatic and pulmonary nuclear factor kappa B (NFkB), cyclooxygenase 2 (COX-2), regulated Pulmonary upon activation normal T cell expressed and secreted (RANTES) or CCL5, and monocyte chemo-attractant protein 1 (MCP-1) in a dose dependent manner.