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Full-Text (PDF) Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 Review on the Third International Neuroinflammation Congress and Student Fes tival of Neuroscience in Mashhad University of Medical Sciences 1 2 1, 3* Sayed Mos tafa Modarres Mousavi , Sajad Sahab Negah , Ali Gorji 1Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran 2Department of Neuroscience, Mashhad University of Medical Sciences, Mashhad, Iran 3 Epilepsy Research Center, Department of Neurology and Neurosurgery, Wes tfälische Wilhelms-Universität Müns ter, Müns ter, Germany Article Info: Received: 11 June 2019 Revised: 12 June 2019 Accepted: 13 June 2019 ABSTRACT Introduction: Neuroinflammation congress was the third in a series of annual events aimed to facilitate the inves tigative and analytical discussions on a range of neuroinflammatory diseases. The neuroinflammation congress focused on various neuroinflammatory disorders, including multiple sclerosis, brain tumors, epilepsy, and neurodegenerative diseases. The conference was held in June 11-13, 2019 and organized by Mashhad University of Medical Sciences and Muns ter University, which aimed to shed light on the causes of neuroinflammatory diseases and uncover new treatment pathways. Conclusion: Through a comprehensive scientific program with a broad basic and clinical aspects, we discussed the basic aspects of neuroinflammation and neurodegeneration up to the s tate-of-the-art treatments. In this congress, 334 scientific topics were presented and discussed. Key words: 1. Nervous Sys tem Diseases 2. Inflammation Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] 3. Congress 4. Iran 5. Germany *Corresponding Author: Ali Gorji E-mail: gorjial@uni-muens ter.de 111 دوره هفتم، شماره سوم، تابستان 1398 مروری بر سومين همايش بين المللی التهاب سيستم عصبی و سومين فستيوال دانشجويی علوم اعصاب در دانشگاه علوم پزشکی مشهد سيد مصطفی مدرس موسوی1، سجاد سحاب نگاه2، علی گرجی3 ،1* 1مرکز تحقیقات علوم اعصاب شفا، بیمارستان خاتم اﻻنبیا، تهران، ایران 2گروه علوم اعصاب، دانشگاه علوم پزشکی مشهد، مشهد، ایران 3مرکز تحقیقات صرع، گروه نورولوژی و جراحی مغز و اعصاب، دانشگاه مونستر، مونستر، آلمان اطﻻعات مقاله: تاريخ دريافت: 21 خرداد 1398 اصﻻحيه: 22 خرداد 1398 تاريخ پذيرش: 23 خرداد 1398 چــــــــكيد ه مقدمه: همایش التهاب سیستم عصبي سومین سري از رویدادهاي ساﻻنه است که بررسي و تجزیه و تحلیل بحث طیف بیماري هاي التهاب عصبي را تسهیل مي کند. همایش التهاب سیستم عصبي بر روي اختﻻﻻت التهاب عصبي از قبیل مالتیپل اسکلروز، تومورهاي مغزي، صرع و اختﻻﻻت تحلیل برندة سیستم عصبي تمرکز دارد. همایش در 23-21 خرداد 1398 توسط دانشگاه علوم پزشکي مشهد و دانشگاه مونستر برگزار شد که هدف آن روشن ساختن علت بیماري هاي التهاب عصبي و کشف مسیرهاي جدید درمان بود. نتيجهگيري: ما در مورد جنبه هاي اصلي التهاب عصبي و بیماري هاي تحلیل برندة عصبي توسط یك برنامة علمي جامع با تمرکز بر وضعیت پایه و بالیني، تا مرحلة پیشرفتة درمان بحث کردیم. در این همایش 334 عنوان علمي ارائه و بحث گردید. كليد واژه ها: 1. بیماریهــای سیســتم عصبــی 2. التهاب [ Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 3. همایش 4. ایران 5. آلمان * نويسنده مسئول: علی گرجی آدرس الکترونيکي: gorjial@uni-muens ter.de 112112112 Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 مقدمه نتيجه گيری ایــن همایــش کــه توســط دانشــکده پزشــکی دانشــگاه علــوم در ایــن همایــش در دو بخــش ســخنرانی ها و پوســترها پزشــکی مشــهد و دانشــگاه مونســتر آلمــان برگــزار گردیــد، جنبه هــای مختلــف التهــاب در بیماری هــای عصبــی در بــه بررســی نقــش التهــاب در بیماریهــای سیســتم عصبــی گســتره علــوم پایــه و بالینــی توســط محققــان مختلفــی از مرکــزی از قبیــل مالتیپــل اســکلروز، صــرع، آنســفالیت مغــزی، کشــورهای ایــران و آلمــان مــورد بحــث و تبــادل نظــر قــرار تومورهــای مغــزی و بیماریهــای تحلیــل برنــده سیســتم گرفــت، کــه خﻻصــه مقــاﻻت آنهــا در ادامــه جهــت مطالعــة عصبــی میپــردازد. همچنیــن بــه نقــش ســلولهای بنیــادی، عﻻقه منــدان و بازگشــایی افقهــای جدیــد تحقیقاتــی و نانوتکنولــوژی و هنــر درمانــی در درمــان بیماریهــای سیســتم بالینــی پیــش روی پژوهشــگران علــوم اعصــاب آورده شــده عصبــی مرکــزی بــا زمینــه التهابــی پرداخته شــده اســت )7-1(. اســت. Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] 113 دوره هفتم، شماره سوم، تابستان 1398 The Neuroscience Journal of Shefaye Khatam Meeting Abstracts Open Access rd Abs tract Book of The 3 International Neuroinflammation rd Congress & The 3 Student Fes tival of Neuroscience 11-13 June, 2019, Mashhad, Iran. Oral Presentations O1 O2 Evaluation of Effects on Improvement of Muscle Cytotoxic T-Cells Cause Hippocampal Sclerosis in an Strength, Prevention of Oligodendrocytes and Myelin Animal Model of Autoimmune Limbic Encephalitis Damage in Brain, Animal Model of MS Disease Marco Gallus1*, Andre Dik1, Veno Narayanan1, Alireza Lotfi1, Nazem Ghasemi2, Zahra Abroodi2 Gordon Hicking1, Tobias Ruck1, ManuelaCerina1, Lydia Wachsmuth2, Cornelius Faber2, Sven G Meuth1, Department of Anatomical Sciences, Faculty of Medicine, Isfahan Nico Melzer1 University of Medical Sciences, Isfahan, Iran 1Institute of Translational Neurology, Department of Neurology, The Neuroscience Journal of Shefaye Khatam, 2019; 7(3): O1 University of Münster, Münster, Germany multiple sclerosis (MS) is a disorder with autoimmune 2Department of Radiology, University of Münster, Münster, pathophysiology which is accompanied by neurological Germany disability. Astaxanthin (AST) can be effective in The Neuroscience Journal of Shefaye Khatam, 2019; 7(3): O2 prevention of this abnormal conditions because of its ability to cross the blood brain barrier and the other Autoimmune limbic encephalitis (ALE) describes reasons are antioxidant and nerve protection effect. The group of autoimmune inflammatory syndromes, purpose of this study is to evaluate AST effect on MS often associated with cancer and characterized by prevention by appraising the muscle strength, prevention neurocognitive impairment, psychiatric symptoms like of oligodendrocyte cells and myelin degradation in Rat depression and mesial temporal lobe epilepsy. Magnetic brain. 4o wistar rats were divided into four experimental resonance imaging (MRI) initially shows an edema groups: control, cuprizone, sham (cuprizone + DMSO) with swelling and T2-signal increase of the amygdala and astaxanthin. AST group received cuprizone and hippocampus which subsequently may turn into (0.6%) and AST (3mg/Kg) coincidently for four hippocampal sclerosis with atrophy and persisting T2- weeks by gavaging. During the study we evaluate signal increase. In some patients autoantibodies against muscle strength by using a behavioral basket test, the intracellular neural antigens can be detected in serum percentage of cell expressing A2B5 and MOG markers and cerebrospinal fluid. In these cases, cytotoxic Downloaded from shefayekhatam.ir at 21:50 +0330 on Tuesday October 5th 2021 [ DOI: 10.29252/shefa.7.3.111 ] by immunohistochemistry technique. Myelin density T cells (CTL) are thought to cause lysis of neurons was evaluated by luxal fast blue staining. We use RT which liberate intracellular antigens that trigger a B PCR in order to measuring MBP, MOG and PDGFr cell response with formation of autoantibodies. To gene expression. Using Image J and SPSS softwares,the better understand the pathophysiological mechanisms, results were analyzed by one-way ANOVA test. our data the goal of this study was to develop a CTL-mediated in immunochemistry and other evaluation techniques animal model of ALE. To that aim, we took advantage showed that the percentage of mature oligodendrocytes of the Combined Adjuvant for Synergistic Activation of and oligodendrocyte progenitor cells in the AST group Cellular immunity (CASAC) to induce a CTL-mediated were remarkable higher than those in the sham and answer against ovalbumin expressing hippocampal cuprizone group. In addition, myelin density and muscle CA1 neurons, created via stereotaxic injection of strength in AST group were higher than the those an adenovirus vector encoding for ovalbumin or cuprizone and sham group. (p≤0.05). this study confirms a control protein under the control of a synapsin the positive effects of AST and natural compounds promoter. Immunohistochemical staining showed containing AST in the prevention of oligodendrocytes infiltrations of CTLs in the hippocampus leading to and myelin ddestruction in the people susceptible to MS. astrocytosis, microglia activation and neuronal death. 114114114 Review ARticle دوره هفتم، شماره سوم، تابستان 1398 دوره هفتم، شماره سوم، تابستان 1398 This corresponds to an antigen-dependent hippocampal Spatial learning and memory was evaluated using atrophy as demonstrated by MRI and memory Morris water maze test after the 11th PTZ injection. disturbance as revealed by the Novel Object Recognition Animals have received 13 injections of PTZ and then, Test in mice. Taken together, we demonstrate that CTL brain tissues were removed. Immunostaining against can cause hippocampal sclerosis in an animal model of NeuN and GFAP respectively as mature neuronal and ALE. astrocyte markers were performed on brain sections. High performance liquid chromatography (HPLC) was O3 performed to measure the ursin content in hippocampus. Art and Epilepsy Our results showed that ursin administration reduced the seizures behavior and prevented cognitive impairment Shaghayegh Gorji in fully kindled animals. The results of HPLC analysis Epilepsy Research
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