Final Report Table of Contents

General Remarks______3 Committees______5 Attendance______9 Abstracts______12 Posters______13 Registration Fees______14 Scientific Sessions______15 Program Overview______15 Plenary Lectures______17 Awards______19 Opening & Closing Sessions______21 Services______23 SpecificActivities ______26 Biochemistry in the City______32 Biochemistry in Cuisine______32 Genes in a Bottle______33 Meeting with Nobel Laureates______34 Lectures Open to the Public______36 Young Scientists Forum/Program______39 Bursaries______41 Sponsors______42 Exhibitors______43 Website______45 Special Issues______48 Media______49 Social Events______51 Financial Report______54

— 2 — General Remarks

The joint 22nd IUBMB & 37th FEBS Congress was held from 4th to 9th September 2012 in Sevilla, Spain. The meeting was organized by the Spanish Society for Biochemistry and Molecular Biology (SEBBM), along with the Portuguese Society for Biochemistry (SPB) as a partner society. The main theme of the Congress was “From Single Molecules to Systems Biology”. Recent spectacular advances in “-omic” disciplines and information technology have led to multidisciplinarity and integration becoming key features of post-genomic and proteomic research. Genes, gene products, their regulatory networks and their interactions with their environment must be analyzed not only at the molecular level, but also as components of higher order structures, metabolic pathways or entire cells and organisms. This branch of research, termed “Systems Biology”, combines concepts in a holistic approach from molecular biology, engineering sciences, mathematics and information technology to complex biological systems such as living cells. We would like to praise the excellent scientific level of all abstracts submitted. With a total of 1,854 abstracts approved, 1,689 posters and 122 oral communications were presented. We would also like to highlight the awarding of registration fee waivers to 498 PhD students and young scientists. The Congress brought together 59 exhibitors and 2,454 participants from 73 different countries spanning five continents. Events and speakers reflected great geographical diversity as well as the important contributions made by both sexes. The female:male participant ratio was 55:45. A total of 20 plenary lectures, including those of six Nobel Laureates, and 137 symposium and workshop lectures were delivered by internationally renowned experts in their fields. Of particular note is that both the European Molecular Biology Organization (EMBO) and the European Research Council (ERC) organized sessions during the congress, thus strengthening FEBS’ and IUBMB’ links and collaboration with these major European science organizations. The program of the meeting followed the standard format for typical FEBS and IUBMB Congresses, with morning and evening sessions running over six days. Additionally, it incorporated the main events of the SEBBM Congress, including the meetings of its 20 scientific groups and lectures delivered by researchers from Argentina, Chile and Mexico. As local organizers, we intended to add value to the Congress experience by developing new ideas and creating novel activities, such as the ‘Biochemistry in Cuisine’ to show scientific principles underlying modern gastronomy, the ‘Guided Poster Tour’ to facilitate the exchange between speakers and poster presenters, and the ‘Portrait Gallery’ to honor 24 outstanding female scientists. Also worth a special mention is the ‘Abstract Search Online Service’ by which all approved abstracts were made available on the official website about a month prior to the congress, allowing participants to comfortably decide in advance which poster to visit and which presentation to attend. Other novel Services such as the Conference App, the Child Care at the venue, or the Poster Printing On Site were also very much appreciated.

— 3 — General Remarks

Immediately prior to the Congress, the 12th FEBS Young Scientists’ Forum was held as a joint event with the IUBMB Young Scientists Program, and also along with the FEBS Fellows Meeting for the first time, involving circa 150 outstanding young scientists. The joint meeting took place from 1st to 4th September 2012 in Costa Ballena, on the Southern Coast of Spain. With the goal of bringing science closer to a wider audience, a number of activities took place under the umbrella of the ‘Biochemistry in the City’ initiative – namely two ‘Round-Tables Open to the Public’ (one on cancer and one on functional food), a course entitled ‘And You? Me, a Biochemist!’ to encourage high school students to study science at university, an Introductory Course in Biochemical Research as well as the science for non-scientists activity ‘Genes in a bottle’ where passers-by could isolate DNA molecules from a buccal swab. In addition, a ‘Meeting with Nobel Laureates’ was held at a downtown hotel with the aim of making people realize how crucial Science is for the future development of the knowledge-based economy. Under the theme “From Single Molecules to Systems Biology”, we hope to have fulfilled delegates’ expectations by providing a quality program and a good arena for expanding knowledge and networking.

Miguel A. De la Rosa, Chair of Organizing Committee Joan Guinovart, Chair of Scientific Committee Irene Díaz-Moreno, Secretary of Organizing Committee Idalino Rocha, Chair’s Office

— 4 — Committees

Presidency Their Royal Highnesses the Prince and the Princess of Asturias

Members President of the Government of Spain (Spanish Prime Minister) President of the Andalusian Autonomous Government Minister of Economy and Competitiveness Minister of Education, Culture & Sports Mayor, City of Sevilla Secretary of State for Research, Development and Innovation Regional Minister of Economy, Innovation and Science President, Sevilla Provincial Council President, Spanish National Research Council

Honorary Committee President, Universidad de Sevilla President, Universidad Internacional de Andalucía President, Universidad Pablo de Olavide President, Sevillian Academy of Sciences President, Cartuja Scientific and Technological Park Deputy Master, Royal Cavalry Armory of Sevilla

— 5 — Committees

Andrés Aguilera Spain Catalina Alarcón Spain Jesús Angulo Spain Joaquim Ariño Spain Patricia Boya Spain Miguel Castanho Portugal F. Javier Cejudo Spain Sebastián Chávez Spain Emilio Fernández-Reyes Spain Antonio Ferrer-Montiel Spain F. Javier Florencio Spain José M. García-Fernández Spain Miguel García-Guerrero Spain Carlos Gómez-Moreno Spain Victoria Guixé Chile Ángel Herráez Spain Manuel Hervás Spain Abdelaziz Hmyene Morocco Alberto R. Kornblihtt Argentina Catalina Lara Spain José López-Barneo Spain Luis Mayorga Argentina F. Molina-Heredia Spain Fernando Moreno Spain Helena Nader Brazil Organizing Committee Secretary: Irene Díaz-Moreno Chair: Miguel Ángel de la Rosa José Á. Navarro Spain Treasurer: Antonio Díaz-Quintana Treasurer: Plácido Navas-Lloret Spain Pedro M. Nieto Spain JA Olate Aravena Chile Manuel Pérez Spain Elizabeth Pintado Spain Juan Luis Ramos Spain Luis C. Romero Spain Joaquim Ros Spain Enrique de la Rosa Spain Manuela Rueda Spain Rafael Salto Spain Pilar Santisteban Spain Arantxa Tabernero Spain Jorge Vázquez Ramos Mexico José Mª. Vega Spain Agustín Vioque Spain

— 6 — Committees

Cecilia Arraiano Portugal Dario Alessi United Kingdom Alicia Alonso Spain Mariano Barbacid Spain Miguel Beato Spain María A. Blasco Spain M. Leonor Cancela Portugal Julio E. Celis Denmark Ilona I. Grabinger Chile Daniela Corda Italy Frédéric Dardel France Ana Belén Elgoyhen Argentina Ernesto Freire United States Ramón Gomis Spain Fotis C. Kafatos United Kingdom Maria Leptin Germany Carlos López-Otín Spain Federico Mayor Spain

Chair: Joan Guinovart M. Teresa Miras Portugal Scientific Committee Ángela Nieto Spain Mary Osborn Germany Montserrat Pagés Spain Richard. N. Perham United Kingdom Francesc Posas Spain Catarina Resende Portugal Isabel Varela-Nieto Spain William J. Whelan United States Felix Wieland Germany Shi Yigong China

— 7 — Committees

Carlos E. Argaraña Argentina Jesús Ávila Spain Angelo Azzi United States Jorge Babul Chile M. Luz Cárdenas France Khalid Fares Morocco Debora Foguel Brazil Masamitsu Futai Japan Carlos Gancedo Spain Cristina Garmendia Spain Efstathios Gonos Greece Félix Goñi Spain Robert Huber Germany Nai-He Jing China Karl Kuchler Austria Fernando López-Casillas Mexico Carlos Martínez-Alonso Spain Iain Mattaj Germany Phillip Nagley Australia Yogeshkumar S. Naik Zimbabwe Uhtaek Oh South Korea Glaucius Oliva Brazil Advisory Committee Sergio Papa Italy Iqbal Parker South Africa Israel Pecht Israel Gregory A. Petsko United States Claudina Rodrigues-Pousada Portugal Vicente Rubio Spain Margarita Salas Spain Willy Stalmans Belgium Adam Szewczyk Poland Kenneth N. Timmis Germany Jia-Rui Wu China Kurt Wüthrich Switzerland Bianca Zingales Brazil

— 8 — Attendance

2,454 registered attendees in total

73 participant countries spanning five continents

— 9 — Attendance

Top 24 Countries by Number of Participants

Spain 1023 South Korea 43

Turkey 123 United States 43

Portugal 105 Chile 29

Poland 104 Romania 29

Italy 79 Hungary 26

United Kingdom 76 Australia 24

Russia 73 Switzerland 21

Japan 64 Serbia 20

Brazil 52 Greece 20

Germany 58 Sweden 19

Czech Republic 50 Israel 18

France 47 Netherlands 18

— 10 — Attendance

— 11 — Abstracts

Volume 279 Supplement 1 September 2012 Volume 279 Supplement 1 September 2012 pp.1–600

List of Abstracts W07 – W08 Science and Society 42 Volume 279 Supplement 1 September 2012 | ISSN 1742-464X www.febsjournal.org PL – Plenary Lectures W07 AIDS: Perspectives and New Therapies 42 W08 Malaria in the Developing World 43 S – Symposia 6 W09 – Science in School 44 S01 Single Molecules 6 W10 – W11 Biochemical Education 45 S01.1 Protein-Nucleic Acid interactions 6 W10 Teaching Molecular Evolution: a Unifying S01.2 Protein Interactions and Networks 7 Principle of Biochemistry 45 S01.3 Membranes and Proteins 8 W11 Research into Effective Teaching Strategies: S01.4 Intrinsically Disordered Proteins 9 what Biochemistry is Learning from S01.5 Engineering and Design 10 Other Sciences 46 S02 Trends in Biochemistry 12 W12 Women in Biochemistry: from Past to Future 47 Abstracts S02.1 Genome Dynamics 12 S02.2 Transcription and Chromatin 13 Special Events 48 S02.3 RNA Biogenesis and Processing 14 SEBBM Congress 48 Plenary Lectures 48 S02.4 Autophagy and Protein Homeostasis 15 nd S02.5 Integrated Cell Structure and Function 16 Spanish-Mexican Symposium 48 22 IUBMB & S03 Beyond Biochemistry 18 NMR in Biology 50 th S03.1 Ageing 18 Poster Presentations 52 37 FEBS Congress S03.2 Global Regulation and Cell Reprogramming 19 P01 Apoptosis 52 S03.3 Artificial Cells and Genomes 20 P02 Biochemical Education 65 S03.4 Computing with Molecules and Cells 21 P03 Biochemistry and Molecular Biology of Plants 67 S03.5 Dealing with Errors and Evolution 21 P04 Biochemistry in Medical Diagnosis and Therapy 86 S04 Molecular Bases of Diseases 23 P05 Biomembranes and Bioenergetics 119 Seville, Spain S04.1 Neurodegenerative and Organ Degenerative P06 Cell Signaling 136 September 4–9, 2012 Diseases 23 P07 Developmental Biology 185 S04.2 Inflammation and Diseases 24 P08 Free Radicals and Oxidative Stress 192 S04.3 Stem Cells and Their Niches 25 P09 Genomics and Proteomics 224 S04.4 Cancer Genomics and Biomarkers 26 P10 Glycobiology 241 S04.5 Role of Hypoxia in Pathogenesis of P11 Membrane Transporters 253 Inflammation in Cancer 27 P12 Metabolic Regulation 264 S05 Environmental Biochemistry 29 P13 Molecular Bases of Pathology 288 S05.1 Oxidative Stress: Dealing with Oxygen P14 Molecular Biotechnology 329 (Portuguese-Brazilian Conference) 29 P15 Molecular Parasitology 352 S05.2 Dealing with Osmotic Stress 30 P16 Neuroscience 362 S05.3 Life in Extreme Environments P17 Nitrogen Biochemistry and Metabolism 389 (in Memoriam of Costas Drainas) 31 P18 Nutritional Biochemistry 395 S05.4 Responding to Environmental Perception 32 P19 Perinatal Biochemistry 406 S05.5 Molecular Clocks and Cell Cycling 33 P20 Protein Structure and Function 408 P21 Regulation of Gene Expression and Genome Dynamics 479 W – Workshops 35 W01 – W03 Omic Sciences 35 P22 RNA Biology 506 W01 Functional Genomics 35 P23 Single Molecules 512 W02 Proteomics and Signal Transduction 36 P24 Systems Biology 518 W03 Metabolomics 37 P25 Theoretical Molecular Biology 528 W04 Biochemistry in Medical Diagnosis and Therapy 38 P26 Transgenesis in Mammals 535 W05 Forum for Bioentrepreneurs: Successful Technology P27 Others 538 Transfer: from Test Tubes to Industrial Applications 39 Author index 577 W06 Systems Biology 41 Keyword index 599

FEBS_v279_s1_oc.indd 1 8/25/2012 6:17:12 AM

Plenary Lecturers 18 Symposium Speakers 100 Workshop Speakers 33 Posters 1,689

SEBBM Plenary Lectures 2 Spanish-Mexican Speakers 4 Oral Communications* 122

*Selected from posters and not included in the total number of abstracts

NMR in Biology 8

Total Number of Abstracts 1,854

— 12 — Posters

1,689 posters presented during three sessions

Total Day Poster Group Nº per day

SEP 5 05. Biomembranes & Bioenergetics 54 SEP 5 08. Free Radicals & Oxidative Stress 101 SEP 5 11. Membrane Transporters 35 SEP 5 14. Molecular Biotechnology 73 SEP 5 15. Molecular Parasitology 29 SEP 5 18. Nutritional Biochemistry 33 SEP 5 19. Perinatal Biochemistry 5 SEP 5 20. Protein Structure & Function 233 563

SEP 6 01. Apoptosis 42 SEP 6 02. Biochemical Education 5 SEP 6 06. Cell signaling 160 SEP 6 07. Developmental Biology 23 SEP 6 09. Genomics & Proteomics 55 SEP 6 12. Metabolic Regulation 73 SEP 6 16. Neuroscience 83 SEP 6 17. Nitrogen Biochemistry & Metabolism 19 SEP 6 21. Regulation of Gene Expresssion & Genome Dynamics 92 SEP 6 25. Theoretical Molecular Biology 21 SEP 6 26. Transgenesis in Mammals 7 580

SEP 8 03. Biochemistry and Molecular Biology of Plants 60 SEP 8 04. Biochemistry in Medical Diagnosis & Therapy 104 SEP 8 10. Glycobiology 35 SEP 8 13. Molecular Basis of Pathology 126 SEP 8 22. RNA Biology 18 SEP 8 23. Single Molecules 18 SEP 8 24. Systems Biology 31 SEP 8 27. Others 128 SEP 8 28. Late abstracts 26 546

TOTAL 1,689

— 13 — Registration Fees

Late and Early Regular On-site Registration Registration Registration (15 May 2012) (30 June 2012) (1 July on) Academic & Researcher 450 € 500 € 550 € Student 1 200 € 225 € 250 € Non-academic 600 € 700 € 800 € Invited Speaker Free YSP Fellowship Winner 2 Free IUBMB/FEBS/SEBBM Bursary Winner3 Select your fee On-site-1-day registration 150 € Members of Biochemical Societies Reduction of 50% from HINARI B Countries 4 Companion 100 € 150 € 200 €

1Participants claiming this fee had to submit proof of their PhD, MSc or Undergraduate Student status. 2Participants claiming this fee had to submit proof of being a YSP Fellowship Winner. 3IUBMB/FEBS/SEBBM Bursary recipients were entitled to be reimbursed congress registration fee upon check-in in person at the Congress venue (4-9 September 2012. Sevilla, Spain). 4Participants claiming this fee had to submit proof of membership to one of the HINARI B countries Biochemical Societies.

— 14 — Scientific Sessions

Program Overview CONGRESS PROGRAM OVERVIEW

Tuesday, September 4th Wednesday, September 5th Thursday, September 6th 8:30 8:308 8:30 S01 Single Molecules 01.1 Protein-Nucleic Acid Interactions S01 Single Molecules 01.2 Protein Networks 9 S02 Trends in Biochemistry 9 9 02.1 Genome Dynamics S02 Trends in Biochemistry 02.2 Transcription and Chromatin S03 Beyond Biochemistry 03.1 Ageing S03 Beyond Biochemistry 9:30 9:30 9:309 03.2 Global Regulation and Cell Reprogramming S04 Molecular Bases of Diseases 04.1 Neurodegenerative and Organ S04 Molecular Bases of Diseases 04.2 Infl ammation and Diseases 10 10 Degenerative Diseases 101 S05 Environmental Biochemistry S05 Environmental Biochemistry 05.1 Oxidative Stress: Dealing with Oxygen 05.2 Dealing with Osmotic Stress 10:30 10:30 10:3010

11 11 111

11:30 11:30 PL03 Osamu Hayaishi 11:3011 PL07 IUBMB Life

12 12 121

12:30 12:30 PL04 Theodor Bucher 12:3012 PL08 FEBS Journals Awards

13 13 131

13:30 13:30 13:3013

14 14 141

14:30 14:30 Poster Sessions & Specific Activities 14:3014 Poster Sessions & Specific Activities BE 15 15 151

15:30 15:30 15:3015 W01 Functional Genomics W02 Proteomics and Signal Transduction

16 W04 Biochemistry in Medical Diagnosis 161 W05 Forum for Bioentrepreneurs 16 and Therapy W08 Malaria in the Developing World W07 AIDS: Perspectives and New Therapies 16:30 16:3016 W11 Research into Effective Teaching 16:30 W10 Teaching Molecular Evolution: Strategies: What Biochemistry BE a Unifying Principle of Biochemistry BE Is Learning from Other Sciences 17 117 171

17:30 Opening Session 1717:30 PL05 Chester Beatty 17:3017 PL09 EMBO

18 118 181

PL01 IUBMB PL06 Prakash S. Datta SEBBM 01 18:30 1818:30 18:3018 Hermann Niemeyer

19 119 191

19:30 PL02 FEBS 1919:30 19:3019 SEBBM Groups 220 202 20 SEBBM Spanish-Mexican Groups 20:30 2020:30 Symposium 20:3020 Reception 21 221 212

21:30 2121:30 21:3021

22 22 22

16 22:30 22:30 22:30

— 15 — Scientific Sessions

Program Overview

Friday, September 7th Saturday, September 8th Sunday, September 9th 88:30 8:308 S01 Single Molecules S01 Single Molecules 8:308 01.3 Membranes and Proteins S01 Single Molecules 01.4 Intrinsically Disordered Proteins 01.5 Engineering and Design S02 Trends in Biochemistry 9 9 S02 Trends in Biochemistry 02.3 RNA Biogenesis and Processing S02 Trends in Biochemistry 9 02.4 Autophagy and Protein Homeostasis 02.5 Integrated Cell Structure and Function S03 Beyond Biochemistry S03 Beyond Biochemistry 03.3 Artifi cial Cells and Genomes S03 Beyond Biochemistry 99:30 03.4 Computing with Molecules and Cells 99:30 03.5 Dealing with Errors and Evolution 9:309 S04 Molecular Bases of Diseases S04 Molecular Bases of Diseases 04.3 Stem Cells and their Niches S04 Molecular Bases of Diseases 04.4 Cancer Genomics and Biomarkers 04.5 Role of Hypoxia in Pathogenesis of S05 Environmental Biochemistry 110 110 Infl ammation in Cancer 101 05.3 Life in Extreme Environments S05 Environmental Biochemistry 05.4 Responding to Environmental Perception S05 Environmental Biochemistry (In memoriam of Costas Drainas) 05.5 Molecular Clocks and Cell Cycling 1010:30 1010:30 10:301 BE 111 111 PL15 Edward Wood 111 PL10 FEBS/EMBO 1111:30 PL12 Severo Ochoa 1111:30 Women in Science Award 11:301

112 112 PL16 Sir Hans Krebs 121

PL11 Alberto Sols-Fundación BBVA1212:30 PL13 PABMB-Fundación Ramón Areces 1212:30 12:301 Closing Session 113 113 131

1313:30 1313:30 13:30

114 114 14

1414:30 Poster Sessions & Specific Activities 1414:30 14:30

115 115 15

1515:30 1515:30 15:30 W03 Metabolomics 116 116 W06 Systems Biology 16 W09 Science in School BE NMR in Biology 1616:30 1616:30 W12 Women in Biochemistry: from Pastast to FFuture 16:30 117 117 17

1717:30 PL14 Edward C. Slater 1717:30 17:30

118 118 18 SEBBM02 1818:30 Luis Federico Leloir 1818:30 18:30

119 119 19

1919:30 SEBBM Prizes 1919:30 19:30

220 220 20

20:30 20:30 20:30

21 221 21

21:30 2121:30 21:30 Congress Dinner 22 222 22 BE : Biochemical Education 22:30 2222:30 activities 22:30 17

— 16 — Scientific Sessions

Plenary Lectures PLENARY LECTURES

Tuesday, September 4, 2012

17:30 – 17:45 PL00 Opening Lecture Auditorium The ERC - funding frontier research in times of austerity Helga Nowotny (Vienna, AT)

18:00 – 19:00 PL01 IUBMB Auditorium Chair: Carlos Gancedo (Madrid, ES). Laudator: Angelo Azzi (Boston, MA, US) Switches and latches: the control of entry into mitosis Tim Hunt (Hertfordshire, UK)

19:00 – 20:00 PL02 FEBS Auditorium Chair: Sergio Papa (Bari, IT). Laudator: Jaak Järv (Tallinn, EE) Towards a comprehensive description of the proteome by high resolution mass spectrometry Mathias Mann (Martinsried, DE)

Wednesday, September 5, 2012

11:00 – 12:00 PL03 Osamu Hayaishi Auditorium Chair: Miguel G. Guerrero (Sevilla, ES). Laudator: Greg Petsko (Boston, MA, US) Discovery of nitric oxide and cyclic GMP in cell signaling and their role in drug development Ferid Murad (Washington, DC, US)

12:00 – 13:00 PL04 Theodor Bucher Auditorium Chair: Vito Turk (Ljubljana, SI). Laudator: Israel Pecht (Rehovot, IL) Fuzziness of globular and aggregating proteins in neurodegeneration: an NMR spectroscopic view Christian Griesinger (Göttingen, DE)

17:00 – 18:00 PL05 Chester Beatty Auditorium Chair: José M. Vega (Sevilla, ES). Laudator: Stahis Gonos (Athens, GR) Protein quality control by the unfolded protein response Kazutoshi Mori (Kyoto, JP)

18:00 – 19:00 PL06 Prakash S. Datta Auditorium Chair: José M. Mato (Bilbao, ES). Laudator: Adam Szewczyk (Warsaw, PL) Life: expectancies & origins Ada Yonath (Rehovot, IL)

Thursday, September 6, 2012

11:00 – 12:00 PL07 IUBMB Life Auditorium Chair: Fernando Moreno (Oviedo, ES). Laudator: Iqbal Parker (Cape Town, ZA) Targeted therapy: the new lease on life for leukemia Sai-Juan Chen (Shanghai, CN)

12:00 – 12:30 PL08-1 FEBS Letters Award Auditorium Chair: Laszlo Fésüs (Debrecen, HU). Laudator: Felix Wieland (Heidelberg, DE) Oncogenic signaling pathway induced by myeloproliferative neoplasm-associated JAK2 V617F mutant 18 Megumi Funakoshi-Tago (Tokyo, JP)

— 17 — Scientific Sessions

Plenary Lectures PLENARY LECTURES

12:30 – 13:00 PL08-2 FEBS Journal Award Auditorium Chair: Laszlo Fésüs (Debrecen, HU). Laudator: Richard Perham (Cambridge, UK) Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-1-induced repression in kidney epithelial cells Rosemarie M. Carew (Dublin, IE)

17:00 – 18:00 PL09 EMBO Auditorium Chair: Margarita Salas (Madrid, ES). Laudator: Claudina Rodrigues-Pousada (Lisboa, PT) An expanding job description for the master transcriptional regulator Blimp1/Prdm1 during mammalian development Elizabeth Robertson (Oxford, UK)

Friday, September 7, 2012

11:00 – 12:00 PL10 FEBS/EMBO Women in Science Award Auditorium Chair: Lea Sistonen (Turku, FI). Laudator: Erich Nigg (Basel, CH) The dance of DNA: chromatin dynamics during DNA repair Susan M. Gasser (Basel, CH)

12:00 – 13:00 PL11 Alberto Sols-Fundación BBVA Auditorium Chair: Federico Mayor-Menéndez (Madrid, ES). Laudator: Miguel A. De la Rosa (Sevilla, ES) Exploring the cancer and aging hallmarks: from genes to genomes Carlos López-Otín (Oviedo, ES)

Saturday, September 8, 2012

11:00 – 12:00 PL12 Severo Ochoa Auditorium Chair: Jacques-Henry Weil (Strasbourg, FR). Laudator: Willy Stalmans (Leuven, BE) Mechanisms of cellular proteostasis: insights from single molecule approaches Carlos Bustamante (Berkeley, CA, US)

12:00 – 13:00 PL13 PABMB-Fundación Ramón Areces Auditorium Chair: Jorge Babul (Santiago, CL). Laudator: Joan J. Guinovart (Barcelona, ES) TGF- signaling in stem cells and cancer Joan Massagué (New York, NY, US)

17:00 – 18:00 PL14 Edward C. Slater Auditorium Chair: Irene Díaz-Moreno (Sevilla, ES). Laudator: Michael Walsh (Calgary, CA) Intracellular protease machines, structures, mechanisms and drug development Robert Huber (Martinsried, DE)

Sunday, September 9, 2012

10:30 – 11:30 BE PL15 Edward Wood Auditorium Chair: Miguel Castanho (Lisboa, PT). Laudator: Susan Hamilton (Brisbane, AU) Biology past and biology future: where have we been and where are we going? Bruce Alberts (San Francisco, CA, US)

11:30 – 12:30 PL16 Sir Hans Krebs Auditorium Chair: Vicente Rubio (Valencia, ES). Laudator: Alan Fersht (Cambridge, UK) Decoding of mRNA and quality control by the ribosome Venki Ramakrishnan (Cambridge, UK) 19

— 18 — Awards

Federico Mayor - FEBS Diplome d’Honneur

Santiago Grisolia - IUBMB Medal

— 19 — Awards

Angelo Azzi - SEBBM Honorary Member

Israel Pecht - SEBBM Honorary Member

— 20 — Opening & Closing Sessions

Opening

From left to right - FEBS General Secretary, University of Seville Chancellor, City of Sevi- lle Mayor, Andalusia Regional Government President, Spanish Research Council President, IUBMB President, FEBS-IUBMB 2012 Congress Chair

President of the European Research Council addresses the audience

— 21 — Opening & Closing Sessions

Closing

From left to right - FEBS-IUBMB 2012 Congress Chair, IUBMB President, Spanish Secretary of State for Research, FEBS General Secretary, Spanish Biochemical Society President

Organizers and assistants: (from right) Idalino Rocha, Chair’s Office; Miguel A. De la Rosa, Chair of Organizing Committee; Jesús Angulo, Member of Organizing Committee; Irene Díaz-Moreno, Secretary of Organizing Committee; Antonio Díaz-Quintana, Treasurer of Organizing Committee; Joan Guinovart, Chair of Scientific Committee; volunteers.

— 22 — Services

App (by Wiley-Blackwell)

Abstract Search

— 23 — Services

On Site Poster Printing

Child Care

— 24 — Services

Internet Point

— 25 — Specific Activities Speakers’ Corner

— 26 — Specific Activities

Guided Poster Tour

Corporate Seminars • HGE Seminar: How can we assure the quality of genetic testing

• ERC Seminar: The European Research Council, a great funding opportunity

• Workshop GE Healthcare: A closer look at Binding Interactions using SPR and ITC

• Cellectis Bioresearch: Seminar TALENTM, A new era of targeted gene editing

— 27 — Specific Activities Women Career Lunch

Portrait Gallery

— 28 — Specific Activities Science in School

CIENCIA EN LA ESCUELA

BIODIVERSIDAD Y EVOLUCIÓN

— 29 — Specific Activities

Course: And You? Me, a Biochemist!

Curso de introducción a la bioquímica y biología molecular para alumnos de bachillerato

¿Y TÚ?

Del 3 al 7 de septiembre de 2012

— 30 — Specific Activities

Introductory Course in Biochemical Research

Sede del curso: Salón de Actos del CIC-Cartuja Curso de (Sevilla) Iniciación

Fecha: a la Lunes 3 (tarde) y martes 4 Investigación (mañana) de septiembre de 2012 en Bioquímica y Biología Coordinadoras: Katiuska González Arzola (IBVF, Molecular cicCartuja) Natalia Pérez Hernández (IIQ, cicCartuja)

Sevilla, 3-4 de www.iubmb-febs-2012.org [email protected] septiembre de 2012

— 31 — Biochemistry in the City

Biochemistry in Cuisine

Calcium-oxide-treated orange wedge

Blood saussage macaron

Tube with false vanilla

Tube of chocolate and toffee paste

— 32 — Genes en el Bote ¿QuieresBiochemistry ver tu ADN? in the City

Genes in a Bottle

Would you like to see your DNA?

VICERRECTORADO DE RELACIONES INSTITUCIONALES VICERRECTORADO DE INVESTIGACIÓN

— 33 — Biochemistry in the City

Meeting with Nobel Laureates

— 34 — Biochemistry in the City

Meeting with Nobel Laureates

— 35 — Biochemistry in the City

Lectures Open to the Public

BIOQUÍMICA en la CALLE

— 36 — Biochemistry in the City

Lectures on Cancer — New Discoveries and Therapies

— 37 — Biochemistry in the City

Lectures on Functional Food — Health and Aging

— 38 — Young Scientists Forum/Program

Costa Ballena, Cádiz, Spain

— 39 — Young Scientists Forum/Program

Costa Ballena, Cádiz, Spain

— 40 — Bursaries

Number Budget

246 72,700 €

58 15,155 €

194 48,375 €

Total 498 136,230 €

— 41 — Sponsors

Institutions

VIP Sponsors Privileged Sponsors Strategic Sponsors

General Sponsors SEBBM Long Term Sponsors

Exhibitors

Other Sponsors

— 42 — EXHIBITORS Exhibitors

Booths No.

ACS Publications 1 Agilent Technologies 31 American Association for the Advancement of Science (AAAS) 47-48 American Society for Biochemistry and Molecular Biology (ASBMB) 3 Biochemical Society 24 Bioline 7 Bio-Rad 26-27-28 Bruker Española S.A. 42-43-44 Cayman Chemical 14 Cell Signaling Technology & New England BioLabs (CST) 39 Cellectis bioresearch 25 cicCartuja (Scientifi c Research Center Isla de la Cartuja) 12 De Gruyter 11 Deutsche Forschungsgemeinschaft (DFG) - German Research Foundation 5 ELGA LabWater 30 eLife 41 Elsevier 9 Eppendorf 17-18-19 European Molecular Biology Laboratory (EMBL) 49 European Molecular Biology Organization (EMBO) 50 European Research Council (ERC) 36 Federation of European Biochemical Societies (FEBS) 21 Human Frontier Science Program (HFSP) 8 International Union of Biochemistry and Molecular Biology (IUBMB) 34 Laboratorios Conda 4 Merck Millipore 2 Novusbio 38 Panreac 32 Portuguese Biochemical Society (SPB) 23 Progenika Biopharma S.A. 29 Royal Society 6 Sarstedt 10 Sigma 33 Sistemas Genómicos 40 Sociedad Española de Bioquímica y Biología Molecular (SEBBM) 22 Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq) 35 Springer 15-16 St. Jude Children’s Research Hospital 45 Takara Bio Europe 13 The Crystalization Factory 37 Tocris Bioscience 46 Vitro, S.A. 20 Wiley-Blackwell 53-54 10 Wisepress Medical Bookshop 59

— 43 — EXHIBITOR & POSTER AREAExhibitors

Pavilion 3

56 55 57

CATERING b b c c

35 344

CATERING CATERING

333

CHILD CARE SERVICEVIC 30 29

CATERING CATERING Ë b MEETING POINT b Ë c c KE

SPEAKERS’CORNER

26 INTERNET POINT 255

CATERING CATERING

59

Access to the Congress Area (Auditorium, Rooms, Registration Desk) 11

— 44 — Website

— 45 — Website

Clicks on FEBS Journal - Volume 279, Issue Supplement s1 from the 22nd IUBMB & 37th FEBS Congress Website

Locations: 53 Countries

Country Clicks Cyprus ( CY ) 5 Slovakia ( SK ) 5 Country Clicks Netherlands ( NL ) 4 Spain ( ES ) 273 Armenia ( AM ) 4 Poland ( PL ) 45 Hungary ( HU ) 3 Turkey ( TR ) 44 Serbia ( RS ) 3 Portugal ( PT ) 31 Chile ( CL ) 3 France ( FR ) 25 Australia ( AU ) 3 Germany ( DE ) 23 Bulgaria ( BG ) 2 Brazil ( BR ) 23 Latvia ( LV ) 2 Italy ( IT ) 23 Iceland ( IS ) 2 Russian Federation ( RU ) 21 Morocco ( MA ) 2 Romania ( RO ) 19 Uruguay ( UY ) 2 United Kingdom ( GB ) 16 Malaysia ( MY ) 2 Japan ( JP ) 13 Denmark ( DK ) 1 Korea, Republic of ( KR ) 12 Croatia ( HR ) 1 Lithuania ( LT ) 11 Belarus ( BY ) 1 United States ( US ) 11 Nigeria ( NG ) 1 Switzerland ( CH ) 10 Cuba ( CU ) 1 Greece ( GR ) 10 Bolivia ( BO ) 1 Czech Republic ( CZ ) 9 Iran ( IR ) 1 Finland ( FI ) 7 South Africa ( ZA ) 1 Taiwan ( TW ) 7 Tunisia ( TN ) 1 Canada ( CA ) 6 Ukraine ( UA ) 1 Austria ( AT ) 6 Israel ( IL ) 1 Mexico ( MX ) 6 Norway ( NO ) 1 China ( CN ) 5 Kazakhstan ( KZ ) 1 Thailand ( TH ) 5 Unknown 101 — 46 — Website

Clicks on the Congress Picture Gallery

Locations: 58 Countries

Country Clicks Country Clicks Spain ( ES ) 406 Ukraine ( UA ) 7 Portugal ( PT ) 52 Estonia ( EE ) 5 Poland ( PL ) 50 Bulgaria ( BG ) 4 Turkey ( TR ) 41 Denmark ( DK ) 4 Germany ( DE ) 36 Taiwan ( TW ) 4 United Kingdom ( GB ) 33 Canada ( CA ) 4 Italy ( IT ) 25 Cyprus ( CY ) 4 United States ( US ) 25 Thailand ( TH ) 3 Japan ( JP ) 24 South Africa ( ZA ) 3 France ( FR ) 23 Australia ( AU ) 3 Russian Federation ( RU ) 20 Korea, Republic of ( KR ) 3 Czech Republic ( CZ ) 20 Slovenia ( SI ) 3 Brazil ( BR ) 18 Croatia ( HR ) 2 Romania ( RO ) 18 Nigeria ( NG ) 2 Switzerland ( CH ) 12 Latvia ( LV ) 2 Mexico ( MX ) 12 Iceland ( IS ) 2 Netherlands ( NL ) 10 Ireland ( IE ) 2 Greece ( GR ) 10 Kazakhstan ( KZ ) 2 Serbia ( RS ) 9 Belarus ( BY ) 1 Israel ( IL ) 9 New Zealand ( NZ ) 1 Hungary ( HU ) 8 Bolivia ( BO ) 1 China ( CN ) 8 Argentina ( AR ) 1 Lithuania ( LT ) 8 India ( IN ) 1 Slovakia ( SK ) 8 Bosnia and Herzegovina ( BA ) 1 Sweden ( SE ) 8 Uruguay ( UY ) 1 Finland ( FI ) 7 Morocco ( MA ) 1 Austria ( AT ) 7 Singapore ( SG ) 1 Chile ( CL ) 7 Malaysia ( MY ) 1 Norway ( NO ) 7 Unknown 173 — 47 — Special Issues kjl

— 48 — Media

Before the congress

— 49 — Media

During and after the congress

— 50 — Social Events

Welcome Reception

— 51 — Social Events

Congress Dinner

— 52 — SOCIAL PROGRAM AND TOURS

Social Program

Social Events

Welcome Reception Congress Dinner Tuesday, 4 September Social EventsSaturday, 8 September 20:00 - 21:30 h 21:00 - 22:30 h Conference and Exhibition Centre - FIBES Square Previous registration ( 70). Tours Tours Event Tuersday Wednesday Friday Thursday Saturday Sept. 4 Sept. 5 Sept. 6 Sept. 7 Sept.8

WALKING TOUR OF SEVILLE  Starting time: 10:00 am (2 hours) (morning) (morning) (morning) (morning) (morning) Meeting point: Virgen de los Reyes Square, behind the Cathedral

SEVILLIAN TAPAS TOUR  Starting time: 10:30 pm (2 hours) (night) (night) (night) (night) (night) Meeting point: Virgen de los Reyes Square, behind the Cathedral

FLAMENCO SHOW & DINNER  Starting time: 07:00 pm or 09:30 pm (1h 30 min aprox) (evening) (evening) (evening) (evening) (evening) Meeting point: Main entrance of the Palacio Andaluz

SEVILLE ON BIKE  Starting time: 10:30 am – 02:00 pm (aprox) (morning) (morning) (morning) (morning) (morning) Meeting point: NH Plaza de Armas Hotel - Main door

VISIT TO ITALICA AND CARMONA  Starting time: 08:00 am (half-day) (half-day) (half-day) (half-day) (half-day) Meeting point: Conference and Exhibition Center - FIBES Center

VISIT TO WINE CELLAR  Starting time: 10:00 am (half-day) (half-day) (half-day) (half-day) (half-day) Meeting point: Conference and Exhibition Center - FIBES Center

DAY TRIP TO CORDOBA  Starting time: 08:30 am (lunch NOT included) SOCIALMeeting point: PROGRAM Conference and Exhibition AND Center TOURS - FIBES Center

DAY TRIP TO JEREZ  StartingEvent time: 08:30 am (lunch NOT included) Tuersday Wednesday (EquestrianFriday showsThursday only on Saturday)Saturday Sept. 4 Sept. 5 Sept. 6 Sept. 7 Sept.8 14 Meeting point: Conference and Exhibition Center - FIBES Center DAY TRIP TO CADIZ  Starting time: 08:30 am (lunch NOT included) Meeting point: Conference and Exhibition Center - FIBES Center

2 DAYS TRIP TO RONDA AND MALAGA  Starting time: 08:00 am (meals NOT included) Meeting point: Conference and Exhibition Center - FIBES Center

2 DAYS TRIP TO GRANADA  Starting time: 08:30 am (meals NOT included) Meeting point: Conference and Exhibition Center - FIBES Center

— 53 —

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