University of Michigan DEPARTMENT OF Chemistry NEWSLETTER

Letter from the Chair

It’s a pleasure for me to send you greet- carry out faculty searches in organic chem- spring, Mary Browning, Lauren Meyers ings from Ann Arbor and to highlight istry, analytical chemistry, and theoreti- and Phyllis Peters retired from the Uni- some of the exciting news from the De- cal physical chemistry. versity and this summer Wayne Burkhardt partment of Chemistry in the last year. Graduate student recruitment during retired as supervisor of the electronic shop. Faculty and graduate student recruitment the past year has been better than ever in There have been a number of new staff remains a high priority for the Depart- both quality and quantity. In addition to hires in the last year. In the technical area, ment. This past year has been an out- the new students that come with Profes- Dr. Todd Raeker joined the Department as standing one in both areas. sors Fierke and Yaghi, we will have 56 system manager in computing and In January, Professor Edwin Vedejs, new graduate students. It is also encour- Mohammed Hague in the area of NMR. the Moses Gomberg Professor of Chemis- aging to note that at least 15 new entering Diane Viebahn and Laura Martinez joined try, arrived in Ann Arbor from Wisconsin students have research interests in inor- the business office; Jacqueline Kuehn re- with some of his research group. Ed has ganic chemistry. This past year, the De- placed Phyllis Peters and Karen Sturtz now settled in and has put together a partment was successful in obtaining an began as secretary to Professor Vedejs. research group numbering eighteen al- NSF IGERT grant for $2.5 M over five On the University front, a major new ready. Renovations of laboratories for years jointly with the Department of Ma- research initiative has been launched, and Professor Carol Fierke will be completed terials Science in Engineering to train it is called the Life Sciences Institute. in August, and Carol and her group will graduate students in materials science. Last spring, President Bollinger an- arrive then. Another exciting new senior Other news in the Department includes nounced a Life Sciences Commission hire in the past year is Professor Omar the promotions of Dr. Mark Banaszak chaired by Bill Roush from chemistry and Yaghi from Arizona State University. Holl and Dr. Roseanne Sension to Associ- Huda Akil from neurosciences to analyze Omar’s research interests center around ate Professor with tenure. Associate Pro- the status of Life Sciences research at inorganic and materials chemistry. He fessor Gary Glick was promoted to Pro- Michigan and make recommendations for will be a very significant addition to our fessor and named to a Collegiate Chair, a comprehensive initiative. The report of efforts towards materials chemistry. Omar which will be named the Werner this Commission resulted in the projec- has already moved to Ann Arbor and his Bachmann Professor of Chemistry. Pro- tion of a $200 million-dollar investment research group arrives in August. A fourth fessor Mark Meyerhoff finishes his term in the Life Sciences beginning with a 90 addition to our faculty in 1999 is Assis- as Associate Chair for Graduate Student million dollar building to be the first of a tant Professor Nils G. Walter who re- Affairs and will take a sabbatical leave Life Sciences Institute. A search for a ceived his Ph.D. from the Max-Planck- next year. The Department and I are most director will begin this fall. Institute for Biophysical Chemistry in grateful to Mark for the outstanding and In the College, interim Dean Patricia Gottingen, Germany. He will arrive in effective job that he has done. I am Gurin is completing her year as Dean. Pat Ann Arbor from a postdoctoral stay in the pleased to announce that Professor Dimitri has been very supportive of the Department of Microbiology and Molecu- Coucouvanis has agreed to succeed Pro- Department’s efforts in faculty hiring. We lar Genetics at the University of Vermont. fessor Meyerhoff as Associate Chair. appreciate all the hard work she has done Nils’ research plans will focus on the During the past year, Professor Thomas this past year. In August, Professor Shirley structure and dynamics in small catalytic Dunn retired and Professor Richard Neuman from the University of British RNA. His research interests span a vari- Lawton began a retirement furlough year. Columbia will begin her term as Dean of ety of biophysical problems in chemical the College of LS&A. Currently, Profes- biology. In the coming year, we plan to There have been a number of changes and retirements on the staff side. This past sor Neuman is Dean of Arts at British

1999 U-M DEPARTMENT OF CHEMISTRY Columbia. We also have a new Vice- department during the past year. We are Contents President for Research. He is Professor fortunate to have such a loyal group of Fuwwaz Ulaby from the Department of alums. We do plan to have a private Electrical Engineering and Computer Sci- alumni reception at the next national meet- Letter from the Chair ...... 1 ence. He is very interested in preparing a ing of the American Chemical Society in coherent science agenda for LS&A with San Francisco on March 27, 2000. I hope Symposia and Seminars ...... 2 input from the science chairs. to see some of you on this occasion. Spotlight Profiles ...... 3 I would like to thank all of you for your New Faculty ...... 4 generous gifts and financial support to the J. P. Marino Faculty News...... 6 Special Events ...... 7 Graduate Program News Graduate Awards ...... 8 Doctoral Degrees ...... 11 Undergraduate Program News ...13 Undergraduate Awards...... 15 ter Schultz (Berkeley) opened the morn- Summer Research Programs ....17 Symposia/ ing with Functional Molecules: A Lesson Undergraduate Degrees ...... 18 from Nature. Chaitan Khosla (Stanford) Seminars followed with Assembly Line Synthesis Gifts...... 19 The visit of Nobel laureate, Professor Using Modular Enzymes. The afternoon Alumni News ...... 21 Thomas Cech, on May 19 to present the presentations were given by Jack Szostak (Massachusetts General Hospital) In Memoriam ...... 28 annual Bachmann Lecture was one of the high points of the seminar program this RIVA-Protein Fusions: Applications to Faculty Listing ...... 29 year. Professor Cech gave a compelling Directed Protein Evolution and Func- tional Genomics, and Jonathan Ellman Conference Announcements...... 30 review of the discovery of catalytic RNA chemistry and recent results from his labo- (Berkeley) From Small Molecule Librar- Alumni Reply ratory. The lecture and traditional ies to Function. Form...... inside back cover celebratory dinner were among the most The Moses Gomberg Lecture series, stimulating departmental events this year. coordinated by the assistant professors, It has become customary to hold sev- and sponsored by the Dow Chemical Co. eral of the special lectures in May when continued its tradition of inviting distin- The guished leaders from across chemistry Department of Chemistry scheduling is more propitious. In this vein, the Elving Lecture was held the throughout the year. The series began in Newsletter previous week. This biennial affair hon- October with Jon Clardy (Cornell) dis- cussing Natural Products and Their Pro- is published once a year by the Depart- ors an analytical chemist. Dr. Janet ment of Chemistry at the University of Osteryoung who is the director of the tein Targets. In November, Stephen Michigan, Ann Arbor, MI 48109-1055 chemistry program at the National Sci- Benkovic (Penn State) spoke on Enzyme ence Foundation presented this year’s Assembly. Josef Michl (Colorado) spoke lecture. She maintains close ties with her in January on Localization and Delocal- home department and electrochemistry ization of Electron Excitation in Sigma Frameworks. The February lecture was Printed on Recycled Paper oriented research group at North Caro- lina State University. given by Robert Shulman (Yale) on Let Us Do Biochemistry In Vivo. Carl On May 7 the Fifth Annual Michigan Lineberger spoke in March on Organic Chair: Joseph P. Marino Symposium on Contemporary Challenges Radicals, Reactive Intermediates, and Editor: Doreen Fussman in Molecular Medicine was held in the Transition States: Spectroscopy of the Asst. Editor: Agnes Soderbeck department co-hosted with Parke-Davis Reaction Coordinate. In successive weeks Alumni News: Robert C. Taylor Pharmaceutical Research. This year’s in April, lectures were presented by Nicho- theme was “Molecular Diversity at the las Turro (Columbia) Stable Radicals Re- Interface of Chemistry and Biology”. Pe- visited: Supramolecular Stabilization, and The Regents of the University of Michigan: by Yves Chabal (Bell Labs/Lucent) Semi- David A. Brandon, Laurence B. Deitch, Daniel conductor Surface Passivation: The Ubiq- D. Horning, Olivia P. Maynard, Rebecca McGowan, Andrea Fischer Newman, S. Martin uitous Role of Oxygen and Hydrogen. Taylor, Katherine E. White, Lee C. Bollinger, ex World Wide Web Address: officio. Lee C. Bollinger, president. http://www.umich.edu/~michchem The University of Michigan is an equal opportunity/ affirmative action employer. E-mail: [email protected]

2 1999 The annual Floyd Bartell Memorial Lecture, which brings a distinguished Gomberg 2000 Conference physical chemist to the campus, was held in April. The Alpha Chi Sigma fraternity VIIIth International Symposium on Organic Free Radicals selects this speaker and acts as host. This June 25 – 29, 2000 year, Dr. Stephen Berry (Chicago) spoke 1900 2000 on Topographies and Dynamics in Many University of Michigan, Ann Arbor, Mi Dimensions: From Clusters to Proteins. Masato Koreeda, [email protected] These lectures as well as many others http://www.umich.edu/~michchem/gomberg/2000 throughout the academic year provides a rich intellectual feast at the frontiers of the discipline. These seminars are essen- tial to providing a stimulating and vibrant 16th Biennial Conference on program for our students. They are sup- Chemical Education ported by the various corporate sponsors and named endowment funds and also by BCCE July 30 – August 3, 2000 a variety of internal sources including the University of Michigan, Ann Arbor, MI annual alumni and alumnae gifts to the 2000MM department. We are grateful to the many M Rich Rothrock (734) 763-9069 Email: [email protected] supporters of this important activity. http://www.umich.edu/~bcce

has been spending his time studying the rather than e-mail, discussions. His re- Spotlight Profiles details of high-field EPR (electron para- search interests continue to focus on un- magnetic resonance) spectroscopy as op- derstanding the structure of the metal on Faculty, posed to his usual interest in high-energy sites in metalloproteins. His group is particularly interested in the bioinorganic Graduate Students chemistry of Mn and Zn, and has been very active over the last year, even in and Prof. Penner-Hahn’s absence. The nine graduate students and postdocs have made Undergraduates numerous trips to synchrotron laborato- ries across the country and now have a We highlight one faculty member, one large amount of data waiting for his re- graduate student and one undergraduate turn. student to let you know of their special For most of his time at Michigan, Prof. accomplishments in the past year. Al- Penner-Hahn has taught general, physi- though the choice is difficult, consider- cal, or inorganic chemistry courses. This ing the numbers of outstanding people in Fall will see a change, as he works on Chemistry at Michigan, we hope you developing an exciting new “Projects agree this group deserves merit. Laboratory” for biochemistry under- James Penner-Hahn graduates. This course, whose initial development is being supported by the Faculty Member Howard Hughes Medical Institute, will (i.e., x-ray) spectroscopy. Instead of teach- Professor James Penner-Hahn has been provide a structured research opportunity ing classes in introductory chemistry, he for the increasing number of biochemis- at the University of Michigan for the last has been taking classes in introductory 15 years, since joining the faculty in the try concentrators at the University of French. Although the latter have only Michigan. Fall of 1985. He has only been sighted been modestly successful (after a year in briefly in Ann Arbor for the last 12 months the French schools, his children now rou- Professor Penner-Hahn’s sabbatical spending his time at the Centre d’ Etude tinely correct his pronunciation and gram- marked the end of a three-year stint as the Atomique laboratory in Saclay, on the mar) the research has been very success- Associate Chair for the Undergraduate outskirts of Paris, France. Professor ful and has given exciting new insight into Program. Now, refreshed by his leave, he Penner-Hahn has been on a sabbatical the structure of manganese redox enzymes. is looking forward to jumping back into leave in the Department de Biologie University business, as a member of the Cellulaire et Moléculaire, supported by a Although it is with some regret that he departmental Executive Committee and Senior International Fellowship from the will bid adieu to Paris, he is looking for- Graduate Committee, as chair of the physi- Fogarty Center. Thus, for the last year he ward to rejoining his group for personal, cal chemistry search committee, and as a

U-M DEPARTMENT OF CHEMISTRY 3 member of the Rackham Executive Board department of Neurotoxicology, Heather dent study began with the palladium cata- and the University Senate Assembly. In has applied the sensors to single neural lyzed coupling of terminal acetylenes to addition to his University service, Profes- cells, and studied calcium release from halogenated aromatic compounds. He sor Penner-Hahn remains very involved mitochondria during the mitochondrial then pur- in international activities, as chairman of permeability transition. sued re- the International Union of Crystallogra- She has authored and co-authored many search on phy Commission on XAFS, vice-chair of publications, focusing on methods for in- the total the International XAFS Society, co-edi- tracellular analysis, including “Optical synthesis tor of the Journal of Synchrotron Radia- Nanosensors for Chemical Analysis in- of LL- tion, and a member of the editorial boards side Single Living Cells. Part 1: Fabrica- Z1220, a of the Journal of Biological Inorganic tion, Characterization and Methods for fungal Chemistry and the Journal of Inorganic Intracellular Delivery”, and “Part 2: Sen- product Biochemistry. sors Specific for pH and Calcium and the possessing Intracellular Application of PEBBLE Sen- antibacte- sors”, both in press for Analytical Chem- rial prop- Graduate Student istry. Her work has also been featured in erties, un- Heather Clark (Kopelman) is a researcher several magazines, including Science, der a sum- who has focused on the design and appli- Analytical Chemistry, The Economist and mer fel- cation of optical sensors to the analysis of Business Week. The PEBBLE project is lowship single cells. This has led to the develop- scheduled to appear this fall on the ABC from ment of the Nightly News. David White Pfizer. His Honors smallest sen- Heather will begin postdoctoral stud- sors available, thesis is entitled “Organoborane Medi- ies at the University of Connecticut Health ated Asymmetric Reduction of TBDMS each only 20 Center this fall in the Center for Biomedi- nanometers in Protected -hydroxy Ketones.” David will cal Imaging Technology, where she will continue his organic research at Harvard diameter, be studying calcium levels in neural cells called this fall under a National Defense Science using near-field optical microscopy. Her and Engineering Graduate Fellowship. At PEBBLEs husband, Roger, will begin a position at (Probes En- Michigan, his honors include a Goldwater Bayer Pharmaceuticals in combinatorial Scholarship, three summer research fel- capsulated By chemistry. Biologically lowships, a National Starch Scholarship, Localized and the American Institute of Chemists Chemistry Award. If past honors are an Embedding). Undergraduate Student These tiny Heather Clark indication, we should look forward to sensors have David White (honors chemistry, Koreeda) David’s future accomplishments while proven to be a non-invasive method to August 1999 pursuing his Ph.D. and thereafter in academia or industry. measure ion concentrations inside single David has participated in Prof. cells. In collaboration with a group in the Koreeda’s lab for three years. Indepen-

New Faculty

Carol A. Fierke, Professor We are elucidating the catalytic mecha- Biological Catalysis: Molecular Recog- nism and molecular recognition of medi- nition, Enzyme Engineering cally important metalloenzymes, includ- Ph.D., Brandeis University ing carbonic anhydrase (CAII), protein Our goal is to comprehend the high farnesyltransferase, and UDP-3-O-acyl- efficiency and specificity of biological GlcNAC deacetylase. Structure-function catalysts, both proteins and nucleic ac- relationships are being investigated using ids. An understanding of these principles mutagenesis, kinetic analysis, alternative is essential for: interpreting biological substrates, X-ray crystallography, and catalysis in vivo, designing inhibitors for NMR spectroscopy to enhance our under- therapeutic use, and developing novel standing of catalytic zinc sites and our catalysts for a variety of tasks, including ability to design inhibitors useful for the organic synthesis and analysis of com- treatment of glaucoma, cancer and bacte- plex mixtures. rial infections.

4 1999 To identify the catalytic modes used by tion of both the prokaryotic and eukary- including a CAII-based metal ion biosen- ribozymes in comparison to protein cata- otic holoenzymes using crosslinking, crys- sor. We are using “directed evolution” lysts, we are investigating the mechanism tallography, spectroscopy, kinetic analy- approaches to alter (i) the substrate speci- of ribonuclease P, a ribonucleoprotein sis and synthesis of modified RNA mol- ficity of aldolases for use as biocatalysts complex where the RNA component cata- ecules. in organic synthetic reactions and (ii) the lyzes the cleavage of tRNA precursors. Finally, we are rationally redesigning catalytic mechanism of trypsin to provide We are determining the structure and func- proteins for optimization of biosensors, insights into molecular evolution.

tions in the absence of proteins, disman- the spliceosome. As the common tling the dogma that protein enzymes are nucleobases do not fluoresce, we incor- the sole biological carriers of catalytic porate fluorophores into RNA by chemi- activity. As such catalysts, ribozymes cal methods. Steady-state and time-re- need to be extremely dynamic. Their struc- solved fluorescence measurements of tures and interactions with substrates and these site-specifically modified RNAs al- cofactors, such as metal ions and pro- low us to ask questions such as: What is teins, undergo substantial changes over the distance between the attachment sites time scales of microseconds to hours. The of a fluorophore and its quencher (e.g., a major goal of our group is to understand second, so-called acceptor fluorophore)? these dynamics by the combined use of Are there conformationally distinct RNA state-of-the-art chemical, molecular bi- molecules present in solution, so that sepa- ology, and biophysical approaches. In rate distance distributions are observed? particular, we employ fluorescence based How do these distances change over time? techniques to acquire unique kinetic data What influence do cofactors and sequence that allow to dissect the reaction path- modifications have? Our studies help, first, ways of ribozymes. In addition, we are to understand the principles of structure folding in RNA and ribonucleoprotein Nils G. Walter, Assistant Professor extending these techniques both to the complexes and, second, to illuminate the Chemical Biology single-molecule level and to studies in molecular basis of catalysis by RNA. Ap- Ph.D., Max-Planck Institute, Technical live cells. plications include the identification and University of Darmstadt The systems we study range from small RNA catalysts, such as the hammerhead optimization of ribozymes for gene The discovery of catalytic RNAs, or therapy applications within cells and the ribozymes, in the early 1980s was a land- and hepatitis delta virus ribozymes, to large RNA-protein complexes, such as exploration of novel applications for RNA, mark in the biological sciences. RNA was e.g., as biosensor. found to catalyze complex chemical reac-

Omar M. Yaghi, Professor classes of materials, where the molecular Materials Design and Discovery Group: properties have been translated into the Materials Chemistry of Molecular and designed solids, which are then examined Extended Organic and Inorganic Solids for their use in catalysis, sensors, separa- Ph.D., University of Illinois-Urbana tions, transport and information storage. Controlling the atomic structure, to- Specifically, the research efforts in pology and function of extended solid my group include: (1) designing porous state materials is one of the most chal- metal-organic crystals by the copolymer- lenging issues facing chemistry. Our ization of metal ions with organic mol- approach toward addressing this chal- ecules such as 1,4-benzenedicarboxylate, lenge has involved developing synthetic where their multidentate functionalities strategies to the design of extended net- allow the formation of stable open net- works from soluble molecules with spe- works in which highly selective molecu- cial emphasis on the synthesis of inor- lar recognition and sensing is achieved; ganic and organic porous materials. Us- (2) the assembly of inorganic metal ox- ing this molecular building block ap- ide, sulfide and nitride networks with proach, it is possible to tailor the pore unprecedented porosity and the use of shape, size and function, thus it has been their voids as microvessels for the syn- possible for my group to generate new thesis and study of unusual compounds;

U-M DEPARTMENT OF CHEMISTRY 5 (3) synthesis of organic zeolites con- Graduate students and postdoctoral fel- Gary Glick was promoted to Werner structed mainly by C-C, C-N, and C-O lows in my group receive training across Bachmann Professor of Chemistry. He bonds by applying ordinary organic reac- several disciplines including organic, in- received funding from NIH to study the tions to the solid state; (4) probing the organic, and materials chemistry with spe- “synthesis of disulfide cross-linked chemical environment within the pores cial attention given to synthesis, struc- nucleic acids.” by gas sorption and liquid sorption iso- ture, and properties. These projects are Richard Goldstein completed five therm measurements in order to design interdisciplinary and provide unique train- months at the Newton Institute at Cam- metal Lewis acid sites for catalysis of ing in molecular and solid state chemis- bridge University (England) attending a organic reactions; (5) preparation of metal- try, with working knowledge and exper- workshop titled “Biomolecular Function organic porous thin films for device ap- tise in several laboratory techniques in- and Evolution in the Context of the Ge- plications and their study by atomic force cluding single crystal and powder diffrac- nome Project.” microscopy. In addition, this group has tion, solution and solid state NMR, ther- recently embarked on a collaborative pro- mal gravimetry, FTIR, UV-Vis, gas chro- Nancy Konigsberg Kerner received the gram aimed at employing theory toward matography, HPLC, electrochemistry, gas 1999 Computerworld Smithsonian Award understanding and predicting framework sorption, BET, electron microscopy, and for her work with CoLABnet. structure, host-guest and template inter- molecular modeling. Raoul Kopelman, the Kasimir Fajans actions, pore reactivity, and structure sta- Collegiate Professor of Chemistry, Phys- bility. ics and Applied Physics, was involved in the organization of and gave presenta- tions at various international conferences in Europe, Japan, and North America. In addition, Professor Kopelman received funding from Media Sense for work on “Glucose NanoSensors for Diabetics” and funding from DARPA for “Dynamic Nano-Platforms for Cancer Detection and Remediation” and NSF/DNR (5 year grant) on “Excitations and Kinetics in Faculty News NanoStructures”. Robert Kuczkowski has been elected a member of the International Advisory Committee of the Ohio State University Arthur Ashe received a provisional U.S. Dimitri Coucouvanis participated in International Symposium on Molecular Patent for “Electron Rich Bridged many international lectures including the Spectroscopy. Metallocenes.” Industrial Applications of Bioinorganic Lawrence Lohr (with John Barker et. Mark Banaszak Holl was promoted to Chemistry at Corfu, Greece (plenary al.) received a three year grant from NASA associate professor with tenure and re- speaker), the International Conference on to work on “State-to-State Rate Constants ceived the prestigious Alfred P. Sloan Bioinorganic Chemistry in Florence, Italy for Computation of Non-LTE Infrared Research Fellowship this year. He re- as well as many national lectures. Radiative Transfer in the Middle Atmo- ceived the Research Corporation General M. David Curtis (with Richard Laine) sphere.” He was the keynote speaker at Award to study “the nature of the chemi- was named co-PI for a National Science the Third Turkish National Chemical cal bonding between two ortho-CF groups Foundation training grant. This grant 3 Physics Meeting at Bogazici University and germanium.” will provide funding for an initial five in Istanbul, Turkey. Professor Emeritus L. S. Bartell pre- year period in the new Integrated Gradu- Neil Marsh received funding from NSF sented seminars on electron diffraction ate Education and Research Training pro- (along with co-P.I. Jim Penner-Hahn) and nucleation at the University of Akron gram. The training grant is a collabora- for the purchase of fermentation equip- and the Universities of North Carolina at tive effort with groups of various Univer- ment. Wilmington and at Charlotte. sity of Michigan faculty as well as indus- trial and government participants. In ad- Mark Meyerhoff completed his term as Larry Beck completed his first year at dition, Professor Curtis received funding Associate Chair for Graduate Affairs. He Michigan as an assistant professor. He from the Department of Energy to con- will begin a year-long sabbatical to re- was awarded an NSF grant to study the tinue his work on reactivity and safety. fresh and restore himself. During the “design and characterization of porous year, he received a U.S. Patent for “Uni- materials for heterogeneous catalysis”. B.J. Evans received a Presidential Award for Excellence in Science, Mathematics tary Sandwich Enzyme Immunoassay Cas- Brian Coppola, as co-PI, received a NSF and Engineering Mentoring from Presi- sette Device and Method of Use”. He is grant for his work on “ChemSense: Pro- dent Bill Clinton at a White House cer- co-investigator with Elzbieta Malinowska moting Representational Competence to emony. Evans was honored for his work on a U.S.-Polish Maria Sklodowska-Cu- Facilitate Understanding and Epistemo- with U of M’s program in scholarly re- rie Joint Fund award. logical Thinking in Chemistry”. He also search for urban minority students. This Michael Morris received funding from traveled to various universities to give award is funded through the National Sci- NIH to study DNA Capillary electrophore- presentations on undergraduate curricu- ence Foundation. sis protocols and processes. He received lum development.

6 1999 the Distinguished Faculty Achievement A. Ramamoorthy received a career de- with two ultra-high-speed temperature- Award from the University of Michigan velopment award from NSF. Addition- programmed ovens. for recognition of his numerous and inno- ally, he was nominated for the Lucille Roseanne Sension was promoted to asso- vative scientific contributions, his extraor- Packard Fellowship for Science and En- ciate professor with tenure. In addition, dinary mentoring of students and his many gineering for 1999. she was elected member-at-large to the years of loyal service to the University. William Roush assumed the position of Division of Chemical Physics of the After an invigorating sabbatical, Will Associate Editor of the Journal of the American Physical Society. Pearson rejoined the faculty to teach, Amiercan Chemical Society. Edwin Vedejs completed his first winter continue research and share his knowl- Richard Sacks received a grant from semester with the Department. The Moses edge from his time away. NIOSH with Ted Zellers for “microana- Gomberg Professor of Chemistry com- Vincent Pecoraro received funding from lytical system for indoor VOC monitor- pleted moving his lab and his group from NIH for his work on “structural models ing.” He was instrumental in obtaining a Wisconsin while obtaining a new grant for multinuclear manganese enzymes”. time-of-flight mass spectrometer with HP from NSF to study “Chiral Nucleophiles 6890 GC and auto injector as well as a GC and Electrophiles in Relay Catalysis”.

Special Events

Sokol Tea On November 3, 1998, the Department hosted a Tea Party with our special guest of honor, Mrs. Margaret Sokol. Profes- sor Joe Marino welcomed all to a feast of pear walnut sandwiches, fruit, chocolate truffles and of course Earl Grey tea. Each year Mrs. Sokol visits the Department to meet with recipients of the Margaret and Herman Sokol Fellowship. The Depart- ment selects two graduate student fel- lows and eight undergraduate fellows. In Sokol Awardees. (back row left to right) Adam Janco (97), Brian addition, the Rackham Graduate School Clarke (98), Erik Hofer (97), Zain Bengali (97), Russell Miller (98), selects a faculty member from the sci- Erik Kornmiller (98). (front left to right) Kendra Frederick (96), ences to receive a Margaret and Herman Angkana Roy (97), Mrs. Margaret Sokol, Joseph Wachter (98), Sokol Faculty Award in the Sciences. Marieke Gilmartin (96) Professor Dimitri Coucouvanis received this award in the fall of 1997. We’ve included his picture this year. We invite all past fellowship recipients to the tea each year. The 1998-99 undergraduate awardees were: Aparna Arunkumar, Jennifer Baker, Brian Clarke, Erik Kornmiller, Russell Miller, Danielle Sgambati, Timothy Stucka, and Joseph Wachter. Prof. Dimitri Coucouvanis and The 1998-99 graduate stu- Mrs. Margaret Sokol dent fellows were Ting-Lan Chiu and Mark Mowery. Xinggao Fang (97), Mrs. Margaret Sokol, Ting-Lan Chiu (98)

U-M DEPARTMENT OF CHEMISTRY 7 tric oxide release technology. These poly- mer materials have many biomedical ap- Graduate Program News plications, including utility for fabricat- ing implantable sensors and as coatings for tubings and catheters which are ex- posed to blood during surgery. This re- search has been the focus of 5 papers 56 Entering Graduate within the last year, and 9 publications Students for Fall, 1999 during her time here at Michigan. The Department anticipates a welcome Ms. Peariso’s research been on the ap- addition of 56 new faces to the graduate plication Application of x-ray absorption program for the Fall 1999 year. With so spectroscopy to the characterization of many new ideas, thoughts, and research spectroscopically ‘silent’ metal ions, with concepts floating about, the Chemistry a primary focus on Zn(II). The majority Building will be THE place to be on of this research has been focused in two campus. areas: 1) mechanistic and geometric stud- ies of the zinc catalyzed methyl transfer reaction carried out by methionine syn- New Program - CSIE thase enzymes; and 2) examining the spa- GSI Award - Jose Santos, Prof. tial and temporal changes in zinc ligand The Department implemented a new Robert Kuczkowski environments during the early develop- Chemical Sciences at the Interface of ment of Zebrafish embryos using x-ray Education(CSIE) program this past year. Award winners were: Dan Hutta, Jose fluorescence microprobe imaging and mi- CSIE is a Graduate Assistance in the Area Santos, Deanne Taylor. cro-XANES spectroscopy. Current ef- of National Need Grant sponsored by the forts are also being placed into determin- Department of Education. The CSIE vi- ing the effect of ligand exchange versus sion is to create an infrastructure for the Outstanding Graduate geometric changes in x-ray absorption scholarship of teaching by broadening near edge structure spectroscopy. the research training. Professor Brian Student Research Coppola is leading this program and has Award implemented CSIE as part of his work as American Chemical a 1998-99 Pew Scholar in the Carnegie Foundation Fellows Program. Society Outstanding Graduate Student Departmental Awards Award for Research and Ceremony and Ice Teaching Cream Social This award is given by the Huron Valley Section of the American Chemical Soci- The Department hosted the annual awards ety. It is intended to recognize achieve- ceremony on May 26, 1999. Our special ment in teaching and research by a gradu- guest was Professor Milton Tamres who ate student. The 1998-99 award winner was on hand to give the Milton Tamres was Heather Clark (Kopelman). Ms. Outstanding Teaching Award. Students, Clark’s research has focused on the de- faculty, staff and postdocs filled up on ice velopment and application of submicron cream sundaes and took delight in the Outstanding Graduate Student recognition of outstanding colleagues. Research - Kelly Mowery, Prof. Mark Meyerhoff This award is given to those students that Outstanding Graduate demonstrate superior research skills and Student Instructor recognizes the creativity of the students and the uniqueness of their topic. Win- Award (GSI) ners of this award have several publica- The Department of Chemistry provides tions and have presented at major national awards annually to outstanding graduate conferences. The 1998-99 Outstanding student instructors. Award recipients are Research Award winners were: Kelly chosen for their contributions to innova- Mowery (Meyerhoff) and Katrina Peariso tion in the lab or classroom, teaching (Penner-Hahn). evaluations, and written recommendations Ms. Mowery’s research has been on ACS Research and Teaching of faculty supervisors. The 1998-99 Out- the development of more biocompatible Award - Heather Clark, Prof. Raoul standing Graduate Student Instructor polymer materials through the use of ni- Kopelman

8 1999 sized optical sensors for the analysis of leader of many. The person takes an is currently developing a novel conver- intracellular ion concentrations. These active role in the Department giving extra gent approach to tetrahydrofurans em- sensors, called PEBBLEs (Probes Encap- time assisting with graduate recruitments, ploying bifunctional allylic organometal- sulated By Biologically Localized Em- working lics. He is also developing a synthetic bedding) are small enough to be con- with fac- route to another anticancer marine mac- tained entirely within a single cell, and ulty and rolide, Pectenotoxin II employing the have proven to be non-invasive. She is staff to newly developed tetrahydrofuran synthe- the co-author of 8 publications. Ms. Clark provide a sis. has taught a variety of courses for the better en- department during her tenure as a gradu- viron- ate student. She has had an appreciable ment for ACS Analytical impact on the lives of many undergradu- graduate Division Fellowship ate students here. students, and also This year, we were fortunate to have a serves as a 1999-00 ACS Analytical Division Full Milton Tamres morale Year Fellowship winner. Jerilyn Timlin and wel- (Morris) received this award and is spon- Outstanding Teaching Leadership Award - fare sup- sored by Proctor and Gamble. Her re- Prof. Mark Meyerhoff, Award port re- search focuses on developing Raman spec- Jenny Holt source for troscopic imaging as a tool for character- the graduate students. The 1998-99 win- izing the chemical microstructure of bone. ner was Jennifer Holt. Using multivariate image processing tech- niques, her group has identified at least In addition to the Departmental awards, three unique mineral species present in we wish to recognize three additional bone and have mapped their distribution awards given to our students this year. in mature and newly formed bone trabe- cular and cortical bone. Correlating these spectroscopic changes with physiological Roche Award microstructure will have a wide-spread (Spring 1999) impact in the biomedical community aid- ing in fracture repair, bone replacement, This is an external award given by the and development of new techniques such Hoffmann-La Roche Company for Excel- as gene-therapy. Milton Tamres Outstanding lence in Organic Chemistry. Teaching Award - Prof. Milton The Department chose one student to Tamres, Prof. Lawrence Bartell, be nominated for this award. The 1998- James Zimmerman Union Carbide 99 winner, Glenn Micalizio (Roush), was Corporation Kenan This award was established in the name of Emeritus Professor Milton Tamres. This Award award recognizes outstanding cumulative This award is given for outstanding gradu- teaching service. ate students working in the field of mea- James Zimmerman (Sacks/Becchetti surement science. (Physics)) was the 1998-99 winner. Since Jeongim Park (Zellers) was the 1999 1994, Jim has been involved in the teaching recipient of the Union Carbide Corpora- of multiple terms of CHEM 106, 125, 130, tion Kenan Award from Michigan. The 462 and 480. He has also been involved in goal of her research is to develop an in- the design of the websites for CHEM 106 strument small enough to be worn by a and CHEM 130. Jim assisted with the worker that can provide selective, simul- departmental GSI training for two years. taneous measurement of personal expo- Jim’s research at Michigan has been prima- sures to organic vapors. The instrument rily focussed on Neutron-Halo Radioactive employs an array of surface-acoustic-wave Nuclear Beams and has also exposed him to (SAW) sensors as well as a thermally the areas of gamma-ray spectroscopy as Roche Award - Dr. Lee E. Babiss, desorbable adsorbent preconcentrator. By well as chemical separation techniques of Glenn C. Micalizio using sensors with different polymer coat- naturally occurring radioisotopes. one of a select few graduate students in ings in the array, it is possible to produce chemistry from top-ranking universities a pattern of responses that can be used to chosen to receive this honor. Glenn’s identify the vapor. Quantification is Leadership Award research focuses on the total synthesis of achieved by calibrating the response peaks against known test-atmosphere concen- The leadership award is given to a gradu- Spongistatin 1, hailed to be one of the trations. ate student who has shown the skills of a most potent inhibitors of cancer cell growth discovered to date. In addition, he

U-M DEPARTMENT OF CHEMISTRY 9 Graduate Fellowships In addition to the awards, the Department provides fellowships to out- standing students. Fellowships given during the past year by the Depart- ment, the College and the Rackham Graduate School include:

Samuel H. Baer Fellows: Joseph Gardner, Katherine Henzler Chemical Biology Interdisciplinary (CBI) Training Grant Samuel H. Baer Fellows - Fellows: Beth Knapp, Nicholas Knuth, Craig McClure, Katherine Henzler, Joseph Jessica Pankuch, Jennifer Pickett Gardner Dow Britton Fellows: Steven Clarke, Joseph Gardner Graduate Degrees for Minorities in Engineering and Science (GEM) Fellow: Jason Brown Graduate Assistance in the Area of National Need (GAANN) Fellows: Melissa Batchelor, Tino Caviggiola, Brett Duersch, Cory Emal, Ashley Holleman, Roxanne Kunz, Stacey Nevins Hughes Predoctoral Fellow: Katherine Henzler Medical Scientist Training Program (MSTP) Fellows: Jeffrey Bednarski, Neal Blatt Pharmacia & Upjohn Fellow: Stephanie Chervin Rackham Merit Fellows: Murphy Brasuel, Jason Brown, Millicent Weldon Rackham One Term Dissertation Fellows: Joan Esson, Neal Blatt GAANN Fellows - Melissa Batchelor, Ashley Holleman, Cory Emal, Rackham Predoctoral Fellow: Laurie Yoder Roxanne Kunz, Stacey Nevins Regents’ Fellows: Jeffrey Bednarski, Neal Blatt, Matthew Hartman, Morris Slutsky, Ryan Sweeder, Craig Vanderkooi, Neal Yakelis Schalon Fellows: Karla Miller, Kimberley O’Neil, Lloyd Simons Sloan Fellows: Angela Carden, Jennifer Holt, Xiaoying Jin, Amy Koren, Carrie Leonard, Rebecca Peebles, Ipsita Roymoulik, Xiaoying Yu Sokol Graduate Fellows: Ting-Lan Chiu, Mark Mowery Walter Yates Fellow: Kirk Hering

These fellowships recognize the academic, research, and teaching excel- lence of our graduate students.

Rackham Merit Fellows - Murphy Brasuel, Jason Brown

Schalon Fellows - Karla Miller, Sloan Fellows - Angela Carden, Carrie Sokol Graduate Fellows - Kimberley O’Neil Leonard, Xiaoying Jin, Jenny Holt Ting-Lan Chiu, Mark Mowery

10 1999 Doctoral Degrees August, December, 1998 and May, 1999

Susan Barker (Kopelman) Investigator at the Eisai Research Institute in Wilmington, Development of Anion and Nitric Oxide Selective Chemical Massachusetts. Sensors and Biosensors. Dr. Barker has accepted a position at the National Institute of Standards and Technology Geoffrey Gardner (Lee) (NIST) in Gaithersburg, Maryland. Porous Coordination Networks Based on Trigonal Ligand Topologies and Silver(I) Trifluoromethanesulfonate. Adam Capitano (Gland) Exploring New Reactions and Establishing Structure/ Shirley Hoenigman (Evans, C.) Reactivity Relationships for Gas-Phase Hydrogen Radicals on Metal Surfaces. Dr. Capitano has accepted a post- Spectroscopic Studies of Pressure-Induced Peturbation in doctoral research position at the Massachusetts Institute of Inclusion Complexation Equilibria. Dr. Hoenigman has Technology. accepted a position as an Assistant Professor of Chemistry at Neumann College in Aston, Pennsylvania.

Jiong Chen (Townsend) Nancy Jestel (Morris) Synthetic Studies of Pyrazine, Indole and Quinoline Nucleo- sides and Related Chemistry. Dr. Chen is a Research Raman Microspectroscopy and Hyperspectral Raman Line Chemist at Pharmacia & Upjohn, Inc. in Kalamazoo, Imaging of Hydrothermal Aluminosilicate Glasses. Dr. Michigan. Jestel is employed as a research scientist for General Electric Plastics in Evansville, Indiana.

David Coutant (Meyerhoff) Neil Law (Pecoraro) The Characterization and Application of Hydroxphenyltriphenylporphyrin- Silica Phases. Properties and Reactivity of Model Manganese Complexes Dr. Coutant is employed by Eli Lilly and Company in for the Oxygen Evolving Complex of Photosystem II. Indianapolis, Indiana. Dr. Law is a post-doctoral researcher at Princeton Univer- sity in New Jersey.

Brett Donovan (Sension) Kyle Litz (Banaszak-Holl) Characterization of the Primary Processes in the Photosys- tem II Relaxation Center by Ultrafast Laser Spectroscopy. Germylenes as Active Ligands on Group-10 Metals

Michael Ducey (Meyerhoff) Hong-Jun Liu (Sension) Characterization and Applications of Microporous Gold The Vibrational Energy Relaxation of Iodine-Aromatic Electrodes in Bioanalysis. Dr. Ducey is currently a post- Hydrocarbon Charge-Transfer Complexes doctoral researcher at the University of Arizona. Emily Maglott (Glick) Xinggao Fang (Ashe) Structural and Kinetic Studies of Tertiary Folding of an Aromatic Boron Heterocycles and Their Metal Complexes. Unmodified Transfer RNA. Dr. Fang is currently a post-doctoral researcher at Los Dr. Maglott is a staff scientist at Avery Dennison in Alamos National Laboratory, New Mexico. Painesville, Ohio.

Brian Gallagher (Pearson) Michael Migawa (Townsend) The Reactions of Alkyl Azides with Alkenes and Alcohols; Synthesis and Reactivity of Novel Pyrrolo[2,3,- Rearrangements Involving Electron Deficient Nitrogen d][1,2,3]Triazine. Dr. Migawa is employed as a Scientist at Atoms: I. Design and Synthesis of Potential Dopamine Isis Pharmaceuticals in Carlsbad, California. Analogs. II. An Approach to the Total Synthesis of (-) – Pictamine. Dr. Gallagher is employed as a Research

U-M DEPARTMENT OF CHEMISTRY 11 Ramasubramanian Narayanan (Laine) Larry Walker (Sension) Novel Routes to Metalloorganics Containing Aluminum Ultrafast Transient Absorption Studies of Vitamin B12 from Minerals. Coenzyemes: Investigation of the Cobalt-Carbon Bond in Alkylcobalamins. Dr. Walker is employed as a Staff Scientist at Clark-MXR Inc. in Dexter, Michigan. James Pennington (Koreeda) Application of α-OXA-αSilyl Radical Cyclization to the Stereocontrolled Synthesis of Trans-α-Lactones. Dr. Patrick Walker (Morris) Pennington is a lecturer at the Department of Chemistry at On-Line Normal Raman Spectroscopic Monitoring of Texas A & M University in College Station, Texas. Isotachophoretic Separations. Dr. Walker is employed as a research scientist for BetzDearborn in Trevose, Pennsylva- nia. Stuart Pullen (Sension) Ultrafast Time-Resolved Spectroscopy of Polyene Reaction Dynamics in Solution: 1,3,5-CIS-Hexatriene and 1,3- Yamin Wang (Koreeda) Cyclohexadiene in Cyclohexane and Hexadecane Solvent. 1. The Total Synthesis of Thiarubrine C, A DNA -Cleaving Dr. Pullen is employed as a Process Evaluation Scientist at Natural1,2-Dithiin 2. Application of Magellan Laboratories Inc., Research Triangle Park, North (Alkoxycarbonylamino)methyl Radical Cyclization to the Carlonia. Total Synthesis of ( ) Sibirine. Dr. Wang is a research scientist at Bayer Corporation Pharmaceutical Division in West Haven, Connecticut. Narayanan Ramamurthy (Meyerhoff) Development and Biomedical Applications of an Improved Polycation-Sensitive Membrane Electrode. Robb Wilson (Kuczkowski) Dr. Ramamurthy is employed by Medtronic Inc. in Parker, Fourier-Transform Microwave Spectroscopy: A Study in Colorado. Spectrometer Automation, Testing and Application. Dr. Wilson has accepted a position as an Assistant Professor at Louisiana State University – Shreveport. Dell Rosa (Coucouvanis) Benzo-Crown Ether, and Catechol Functionalized Salicilyideneimine Complexes and Their Transport Proper- Jin-Hai Yang (Koreeda) ties as a New Class of Supramolecular Complexes. Synthesis of Optically Active trans-Dihydrodial and syn- Dr. Rosa is a post-doctoral researcher in the Chemistry and anti-Diol Epoxide Metabolities of Polycyclic Aromatic Department at the University of Michigan. Hydrocarbons. Dr. Yang is a post-doctoral researcher at Pennsylvania State University. Trevor Rudalevige (Francis) The Study of Fullerene Aggregates in Solution. Kefei Zheng (Lubman) Dr. Rudalevige has accepted a position at the University of Capillary Liquid Chromatography and Mass Spectrometry Massachusetts in Boston, Massachusetts. Study of Biological Molecules. Dr. Zheng is a post- doctoral researcher at the University of California - San Diego Veterans Hospital. Heather Smith (Sacks) Vector Modeling and Tunable Selectivity Strategies for High Speed Gas Chromatography. Yongdong Zhu (Lubman) Fundamental Studies of Matrix-assisted Laser Desorption/ Ionization Time-of-Flight Mass Spectrometry (MALDI- Glen Southard (Curtis) TOF/MS) and its Applications to the Analysis of Biological Conjugated Organometallic Polymers: Materials. Dr. Zhu is employed at Quest Pharmaceutical Poly(Metallocenylene Arene)S and an Acetylide Bridged Services in Delaware. Decamethylhafnocene Acetylide Dimer. Dr. Southard is a post-doctoral researcher at the Coatings Institute at Eastern Michigan University in Ypsilanti, Michigan.

12 1999 Undergraduate Program News

ACS Student Affiliates known “guilty” strand of DNA, was Student Affiliates chapter received an implemented as part of a six-session se- Outstanding Chapter Award for the 1997- This year, the American Chemical Soci- ries of classes for the KidSport summer 1998 academic year. ety Student Affiliates continued to bring camp hosted by the Kinesiology Depart- The newly elected officers for 1999- science to the community through their ment. expanded outreach program. In addition 2000 are: Jennifer Chang and Scott to the traditional National Chemistry Activity at ACS national meetings was Harrison—co-presidents; Benjamin Week event on the diag, the month of maintained this year, with Student Affili- Singer—Vice-President; Ross Smith— October was deemed National Chemistry ate posters being presented at the Boston Treasurer; Désirée Thayer—Secretary/ Month, which included a day of hands-on and Anaheim meetings. At the Boston Historian. Outgoing co-presidents, activities at the Ann Arbor Hands-On meeting, the ACS Phoenix Award was Suzanne Blum and Rebecca Ihrie, will be Museum and outreaches at several area presented to the UM Affiliates, who were completing their senior year and will con- schools. Also, a new DNA station, where recognized for their work on behalf of the tinue to contribute their experience and students extract DNA from bananas and Huron Valley Local Section during Na- advice to the group. use gel electrophoresis to identify an un- tional Chemistry Week. In Anaheim, our Website: http://www.lsa.umich.edu/saa/

Undergraduate lizing Protein of Spinach Photosystem II cross-ring naphthoquinones for testing Using Site-Directed Mutagenesis.” Scott against various cancer cell lines. Nation- Horizons is currently interning at Parke Davis where ally she presented research at the 1998 Our chemistry and biochemistry gradu- he is in a protein crystallography group, ACS spring and fall meetings. The De- ates pursue a number of different career with whom he had an opportunity to col- partment awarded her a Herman and Mar- paths: graduate school, MD/PhD pro- lect diffraction data at the Advanced Pho- garet Sokol Scholarship, a National Starch grams, industrial internships, medicine, ton Source at Argonne National Labora- Scholarship and the ACS Huron Valley public health, teaching, or employment tory. Scott has been recognized nation- Section Outstanding Leadership Award. in industry are a few examples. Some of ally as a Goldwater Scholar, and the de- She will attend UC Davis this fall to this year’s graduates are highlighted be- partment awarded him two summer fel- pursue her Ph.D in organic chemistry. low. For 1998-99 chemistry degrees to- lowships, a National Starch Scholarship, taled twenty-three, biochemistry had a Lubrizol Scholarship and the American Institute of Chemists Biochemistry Award. Amethyst Cook Smith (honors chemis- forty-eight, with five students concen- try biochemistry, C. Evans, May 1999) trating in both programs. He plans to pursue his biochemistry Ph.D. at the University of Wisconsin in a year Amethyst has been in Christine Evans’ and possibly join the ranks of academia. research group for three years, producing Scott Travis Lefurgy (honors biochem- an honors thesis entitled “Polydiacetylene istry, Yocum, May 1999) Monolayers: Electrochemical Character- Carolyn Elaine Owen (honors chemis- ization and Surface Design.” She had Scott, a dual degree student, earned an try, Toogood, December 1998) honors degree in biochemistry and also a two summer fellowships from the depart- degree in voice performance from the Carolyn has had experience in both ment, and a scholarship from the Lubrizol School of Music. His research started in academia and industry. She has had in- Corporation. She was recognized as the Prof. Coppola’s lab where he helped adapt ternships at 3M in optical materials chem- outstanding second year student, received CAChe software on molecular visualiza- istry and is currently at Pharmacia & the ACS Junior Analytical Award and tion for our structure and reactivity class. Upjohn in process development. At Michi- this year received the Seyhan N. Ege Later, he was part of a team to create a gan, she taught a first semester organic Award from the Women in Science and computer program that would teach high- chemistry lab, tutored organic chemistry, Engineering Program. Amethyst was an school students about chemistry by link- chaired the F.E. Bartell Memorial Lecture undergraduate student instructor for ing a manipulable visual model of a mol- for Alpha Chi Sigma Chemical Sciences Chemistry 210 and will continue teach- ecule to its chemical properties. He col- Fraternity, and pursued research for her ing chemistry and integrated physics/ laborated with programmers to design a honors thesis entitled, “The Synthesis of chemistry at Furr High School in Hous- molecule building interface. He then the Amino Hexanoic Acid Fragment of ton, TX through the Teach for America moved on to photosynthesis research in Keramamide J Containing R Stereochem- Program. She earned an honors chemis- Prof. Yocum’s lab where he produced a istry at the C-3 Center.” In the summer of try degree and also a biochemistry de- thesis entitled “Characterization of Struc- 1997, at the University of Minnesota, she gree. Amethyst intends to pursue a Ph.D. ture and Function of Manganese-Stabi- studied the total synthesis of substituted degree in two years.

U-M DEPARTMENT OF CHEMISTRY 13 Jean Dreyfus Boissevain Scholarship The Department received funding from the Camille and Henry Dreyfus Foundation for the Jean Dreyfus Boissevain Scholarship, a scholarship to recognize out- standing undergraduate re- search. Ms. Boissevain was President of the Camille and Henry Dreyfus Foundation from 1956 until 1991. The scholarship recipient for the summers of 1998 and 1999 was Aaron Daniel. Aaron worked with Professor Masato Koreeda during the Scholarships (front left to right) Sara Aeschliman, Ann summer of 1999. His re- Chopp, Angkana Roy, Shirley Lee (back left to right) Ian Aaron Daniel search during that period was Stewart, Jennifer Chang, Nick Keppeler, Jennifer Stahl, attempting to synthesize Desiree Thayer, Milike Bayram dithionate compounds through various reaction path- ways. In previous work, Mr. Daniel worked with Professor Jim Penner- Hahn to conduct research on the alkyl transfer reactions of Cu and Zn. Aaron plans to work for a year, Upperclass Awards then apply to graduate schools to (front left to right) Kevin pursue a Ph.D. in Chemistry. Oh, Laura Khoury, Professor Joseph Marino, Maggie Hui (back left to right) Omer Yilmaz, Michael Bruderly, Manish Sharma, Scott Lefurgy, David White

Margaret and Herman Sokol Scholars 1998-99 1999 Graduation Reception (front l to r) Elizabeth (back left to right) Russell Miller, Brian Clarke, Mieczkowski, Aaron Daniel, David White (middle) Joseph Wachter, Erik Kornmiller. (front left to right) Mindy Grunzke, Jordan Laser, Andrew Bolig, Jeffrey Jennifer Baker, Mrs. Margaret Sokol, Aparna Bryant, Ben Tourkow (back) Elizabeth Rieth, Miguel Arunkumar. (Not present) Timothy Stucka, Danielle Pereira, David Meyer, Kurt Morrison, Tim Murray, Scott Sgambati Lefurgy

14 1999 Undergraduate Awards The 1998-99 Undergraduate Awards ceremony in April 1999 at the Michigan League was well attended. Our guest speaker was Professor Robert Owen, Associate Dean for Undergraduate Education and Long Range Plan- ning in the College of Literature, Science and the Arts. Professor Owen regaled the audience with tales from his undergraduate career in Chemistry. In addition, our special guest of honor was Professor Wilbur Bigelow. Professor Bigelow is the benefactor of the Carlene Friedley Scholarship, which is given in memory of his wife, Alyce Carlene Friedley.

First Year Awards (front left to right) Russell Miller, Douglas Boyer, Samantha Tarras (back left to right) Eyad Abu-Isa, Prof. William Pearson, Ross Smith, Brian Clarke

ACS Leadership Award - Sara Roberts, Prof. Brian Coppola, Prof. Neil Marsh

Carlene Friedley Scholarship (left to right) Shirley Lee, Prof. Wilbur Bigelow, Desiree Thayer, Ann Chopp S.N. Ege WISE Award (left to right) Dr. Cinda Sue Davis, Amethyst Smith, Prof. Seyhan Ege

AXE Outstanding First Year Award (left to right) Erica Guice, Ross Smith, Prof. Brian Coppola

Summer Research Fellowships (front left to right) Rebecca Ihrie, Scott Harrison, Delia Chien, Sara Roberts (middle left to right) Clara Chen, Eric Budor, Ann Chopp, David White, Eric Hyun, (back left to right) Ian Stewart, Nicolas Keppeler, Jesse Kuiper, Jeffrey McMahon, Andrew Waltman

U-M DEPARTMENT OF CHEMISTRY 15 Undergraduate Awards and Sponsors – 1999

1998-99 Margaret and Herman Sokol Scholarships Aparna Arunkumar, Jennifer Baker, Brian Clarke, Erik Kornmiller, Russell Miller, Danielle Sgambati, Timothy Stucka, Joseph Wachter

CRC Outstanding Freshman Achievement Award Douglas Boyer

First Year Chemistry Achievement Awards Eyad Abu-Isa, Brian Clarke, Russell Miller, Ross Smith, Samantha Tarras

AXE Outstanding First Year Ross Smith

Summer Research Funding Abbott Labs Michael Asuncion PPG Industries Andrew Budor PPG Industries Clara Chen James E. Harris Delia Chien Pfizer Inc Ann Chopp Jean Dreyfus Boissevain Aaron Daniel Dow AgroSciences Scott Harrison Abbott Labs Eric Hyun Dow AgroSciences Rebecca Ihrie Pharmacia & Upjohn Fdn Nicholas Keppeler Pharmacia & Upjohn Fdn Jesse Kuiper Alumni Fund Roneil Malkani Amoco Foundation Jeffrey McMahon Pharmacia & Upjohn Fdn Sara Roberts Amoco Foundation Ian Stewart James E. Harris Scholarship Andrew Waltman Alumni Fund David White

Outstanding Second Year Student Eric Hyun

Honors College Vanko Award Michael Bruderly

Helen S. Schaefer Scholarship Sara Aeschliman , Angkana Roy, Jennifer Stahl

Carlene Friedley Scholarship Ann Chopp, Shirley Lee, Desiree Thayer

Lubrizol Scholarship Nick Keppeler

National Starch Scholarship Melike Bayram, Jennifer Chang, Ian Stewart

ACS Analytical Chemistry Award Laura Khoury

Merck Index Jeffrey Bryant, Aaron Daniel, Maggie Hui, Kevin Oh, Omer Yilmaz

Marc Feldmann Award Manish Sharma

ACS Outstanding Senior Leadership Award Sara Roberts

S.N. Ege WISE Award Amethyst Smith

AIC Chemistry Award David White

AIC Biochemistry Award Scott Lefurgy

16 1999 Research Experiences is one of the most effective techniques for program. REU students participated in attracting talented undergraduates to and the following activities which sought to for Undergraduates retaining them in careers in science. As enrich their research experience and bet- (REU) Program part of their research activities, REU stu- ter prepare them for their future careers: dents gain first-hand experience with state science and ethics, industry tours, ca- Summer 1999 of the art equipment and develop exper- reers and graduate school discussions, The Research Experiences for Under- tise in chemical data reduction and analy- research presentations, departmental graduates (REU) program funded by the sis. In this year’s ten-week program, pizza parties, and recreational outings. National Science Foundation (NSF) pro- students carried out research in biochem- The program also provided the opportu- vides opportunities for talented under- istry, analytical, inorganic, organic, and nity for students to co-author papers. To graduate students to participate in re- physical chemistry. maximize interactions between students, search projects during a 10-week period Our summer research program is de- students were housed together in Markley each summer. REU “sites” are estab- signed to match each student with a fac- Hall. A series of regularly scheduled lished by the NSF in all fields of science, ulty member to optimize the research meetings by faculty mentors were held to mathematics, and engineering at host in- experience for all participants. Students give students a broad perspective on cur- stitutions throughout the United States. are provided a stipend, and are assisted rent research directions in chemistry, and At Michigan the program provides un- with housing, parking, and travel ex- the opportunities available for careers in dergraduate students nationwide an op- penses. Those who are in groups tradi- this field. At the end of July 1999, stu- portunity to conduct research in ongoing tionally under-represented in science dents participated in a collective sympo- projects in Chemistry. It provides an ex- (women, members of under-represented sium of area REU sites hosted at Hope ceptional opportunity for undergradu- minorities, and those with disabilities) College, where students displayed post- ates considering a career in science to are particularly urged to apply. This year ers on their projects and, selected partici- engage in substantive research activities eleven undergraduate students were in- pants gave oral presentations on their with scientists working in the forefront vited by site director, Prof. Brian Coppola research. of chemistry. Active research experience to attend the Department of Chemistry’s

List of Summer 1999 REU Participants and their Project Titles

MATTHEW BOYD/Francis University of Michigan, Flint Classical Light Scattering of Polystyrene in Toluene SULIE CROAN/Townsend Southern California College Facile One Pot Conversion of 2-Aminopyridines into 2-Chloro-pyridines KATHERINE ELLISON/Sacks Scripps College Quantitative Analysis and Solvent Management with High Speed Gas Chromatography and Time-of-Flight Mass Spectrometry SATISH IYER/Goldstein University of Massachusetts, Boston A Computational Approach to Understanding Thermostability JENNIFER A. JAKUBOWSKI/Evans C. Union College Liposome Capillary Electrophoresis as a Tool for Analyzing Cell Membrane/Drug Interactions CHRISTOPHER JOHN/Banaszak Holl Muhlenberg College Chemistry Vapor Deposition of Tri-t-Butoxysilanol on Si I. CAGLAR TANRIKULU/Marsh Ohio Wesleyan University The Synthesis of Hexafluoroleucine for the Study of Fluorous Effects in Oligopeptides. TRACY J. TERRY/Coucouvanis University of the South Study of the Nitrogenase Enzymes: The Proposed Synthesis of a P-Cluster Analog SHERRY M. TSAI/Glick Yale University Autoantibody Levels in Lupus-prone mice: Elucidating the Mechanism of a Novel Drug ADAM VAN WYNSBERGHE/Kuczkowski Ohio Wesleyan University Structure Determination of 1,2-Dichlorotetrafluorocyclobutene by FT-MW Spectroscopy KEVIN A. WIER/Curtis Michigan Technical University Synthesis of Dialkoxy-Substituted Thiophenes

U-M DEPARTMENT OF CHEMISTRY 17 Bachelors Degrees August, December, 1998 and May, 1999

CHEMISTRY DEGREES Michael Feld Renee A. Beardslee (Banaszak Holl) – Parke Davis Laura L. Fleischer (Thompson) – research assistant (UM Jeffrey R. Brender (Lohr) * Kellogg Eye Center) Michael I. Bruderly (Marsh) – medicine (UM)* Adam R. Geiger (Toogood) Jeffrey H. Bryant (Curtis) – materials science (U Florida) Robert M. Gomez Sang Ouk Chin (Zellers) Mindy Grunzke (Townsend) – medicine (Temple) Jacquelyne S. Chu (Lee) Maggie Hui (Coward) –human nutrition (UM SPH)* Christopher A. Conrad (Coppola) – Parke Davis Maria Jancevski (Vojtek) – medicine (Wayne State) Catherine E. DeLeeuw (Weiss/Toogood) – medical Sarah M. Johnson (Gafni) sciences (MCP Hahneman)* Shirley A. Kadoura Brian M. Eklov (Coppola) – organic (U Minnesota) Jordan S. Laser Mark A. Even (Meyerhoff) – analytical (UM) Cheong Lee Irwin Iskandar Scott T. Lefurgy (Yocum) –biochemistry (U Wisconsin)* David S. Lewy (Glick) – organic (Scripps Institute)* Irwin M. Liu (Coward) Claudia Lopez (Marino) – medicine (U Connecticut)* Claudia Lopez – medicine (U Connecticut) David R. Meyer – medicine Raymond J. Malewitz Kurt L. Morrison – medicine (Ft. Lauderdale) Jennifer L. Marti (Peliska) * Timiothy J. Murray (Laine) – Cayman Chemical Sarah McDonald Gisele A.Nishiguchi (Laine) – Parke Davis Bryan M. McCormick Carolyne E. Owen (Toogood) – organic (UC Davis)* Elizabeth Mieczkowski (Menon) – research assistant (UM Bharat R. Patel – employed pathology)* Ly Thi Pham – Parke Davis Christopher E. Millikin (Engelke) * Wendy M. Robertson (Glick) – Parke Davis Laquandra Nesbitt Amethyst C. Smith (C Evans) – Teach for America, Edward P. Nicholas (Gafni) Houston* Kevin Oh (Carter-Su) – medicine (UM) Lisa Viculis (Laine) – materials science (UCLA)* Timothy R. Peterson (I Goldstein) Monica V. Rader (Meyerhoff) – epidemiology (UM SPH) Junewai L. Reoma (Uhler) – medicine (UM)* Elizabeth F. Rieth (Franceschi) * BIOCHEMISTRY DEGREES Timothy R. Rozof (Townsend) Farrah Bagaman Bisan A. Salhhi (Thiele) – medicine Chad S. Brody (Andrews) – medicinal chemistry (UM) Manish R. Sharma (Ballou) – medicine (UM)* Michael I. Bruderly – medicine (UM) Michael H. Shaw (Peliska) Austin B. Capper – biomedical science (UM) Amy Y. Shih Jacquelyne S. Chu Amethyst C. Smith (C. Evans) –Teach for America Jason M. Coats David T. Stephensen (Engelke) Kevin D. Cox – public health (UM) Matthew A. Wheatley Emily C. Dawson (Cordes) Grace Shau-Moi Yee (Schacht) – Parke Davis Catherine E. DeLeeuw – medical sciences (MCP Omer H. Yilmaz (Gafni) – medicine (UM) Hahneman) Aidan C. Dysart (R. Goldstein) Angela N. Eickhorst (Kaufman) *Honors Degree (includes undergraduate thesis) Brandon Farley (Seaholtz) *

18 1999 Pui Fan Rees Makins G. Finch Jen-Jen Mao GIFTS Larry Fink Robert Maxwell Sister Suzanne Fleming Gary McClusky Donald Flowers Lowell McCoy Fluor Fdn* James McLean Contributions from private and cor- Gerald Fong Brett Mercer porate donors received from July 1, Ford Motor Co Fund* Merck Co Fdn* 1998 – June 30, 1999. Frances Hummel Seymour Estate Timothy Merkel (* Indicates corporate matching funds.) Phyllis Garland Donald Meyer Howard Garrett Mark Meyerhoff Alumni Gift Fund General Motors Fdn Inc* Veronica Miller Akzo Nobel Inc.* Thomas Giordano Monsanto Fund* American Home Products Corp.* Stewart Gloyer John Moote Theodore Anderson Steven Goates Michael Morris Norman Arends Bruce Goethe Annabel Muenter Herbert Bandes J. Goldberg Richard Neubig Charles Barclay Thomas Gougeon Harry Oswald BASF Corp. Hdq* Arthur Grand John Pendery John Bauman Philip Gravel Mary Perry Rene Bergero David Greenblatt Pharmacia & Upjohn Fdn* Wayne Bergstrom Robert Gregg Wayne Pletcher Richard Boice Ronald Greinke Eric Pohl Barbara Booker Dean Griffith Irvin Potts Steven Boskovich George Grove Margaret Price James Brewbaker Louise Hanson Procter & Gamble Fund* John Bruesch David Hart Edwin Przybylowicz Donald Brundage Steven Henry Ellen Racusin Leonard Bruner Mary Heyde James Reh Diane Burley Kurt Hillig Robert Reynolds Susan Butts Roland Hirsch Rhone-Poulenc Inc* Thomas Caughey Charles Horton Daniel Ricca Michael Chaykovsky Thomas Houser John Rosemergy John Chemerda Jeffrey Hsi Walter Rupprecht Julius Chikos Alan Hutchcroft Joel Schmiegel Gary Chipman James Jackson Erich Schulz Alice Cohen Theodore Jacob Ronald Seamans Jerry Cohen Steven Jordan Elaine Shafrin Michael Collison Jerome Karle Joseph Shepard Eunice Connors Glenn Karseboom Sherwin-Williams Co* Alice Corey John Kath Zhong Shi Ernest Cowell Norman Knight James Sommers Frederick Crane Thomas Korniski Gloria Stevens Renee Cribbins Robert Kuczkowski David Stewart Lyubica Dabich Edgardo Laborde Jack Sweet Scott Damask Robert Landowne Kumiko Takeuchi Scott Damask Carl Leach James Thirtle Merton Davis Ernest Levon Donald Thompson Harold Dawe Gloria Liskanich Richard Tomko Deloitte & Touche* Lockheed Martin Corp.* John Tomlinson Dow Chemical Co. Fdn.* Gordon Lockyer George Towe Roxanne Drnevich Richard Loeppky Mary Trawick Vincent Drnevich Leslie Loh Kelly Triplett David Ebdon Antone Lott Robert Tripp David Edwards George Lowrie Howard Un Edward Eggling Mary Lowther Warner Lambert* Eli Lilly & Company Fdn* Lubrizol Fdn* Toni White May and Walt Family Fund Lucent Technologies* Raymond Wilkinson John MacConnell Joel Wolfe

U-M DEPARTMENT OF CHEMISTRY 19 Katherina Woodward Dow Britton Fellowship Helen Schwartz Schaefer Scholarship Otto Wurzburg Dow Chemical Co Fdn Helen Schwartz Schaefer Arthur Zambito Equipment Fund P.A.S. Smith Scholarship Bachmann Memorial Lecture Fund Lawrence Bartell Elmer Carlson BP Exploration* David Reed Robert Edgerton Wayne Cole David Emerson Monsanto Fund* James E. Harris Scholarship Jerome Horwitz Patrick Mosier Marian Harris Norman Jensen Leland Pence Lawrence Mitchell John Petrasky Kent P. Lanini Memorial Fund Roy Pointer Shell Oil Company Fdn* Dow Chemical Co. Fdn.* Peter Smith Evelyn Tyner Stephen Gaudioso USX Fdn Inc.* Special Scholarships Lawrence Wick Library Fund Abbott Laboratories Fund Frederick Wiselogle Richard Bard American Chemical Society John Callen American Home Products Corp. Biennial Conference Janet Haartz Dow AgroSciences Dow Chemical Co. Fdn. Robert Karpiuk Richard Doyle Minnesota Mining and Manufacturing Irene Piscopo John Griffin Warner Lambert Fdn John Quin Elizabeth Hugel World Heritage Foundation Helen Schaefer National Starch Pfizer Chair Discretionary Fund Parry Scholarship Pharmacia & Upjohn Ayco Charitable Fdn. David Berman PPG Industries Fdn Dan Chapel C Heitsch Samuel Root Robert Damrauer Alfred Kiessel Shell Oil Company Fdn* E.I. DuPont DeNemours & Co* Joseph Morse Melvin Friedland Karen Morse Student Affiliates Carl Johnson Monsanto Fund* Saline Area Schools Minnesota Mining and Manufacturing Robert Paine Procter & Gamble* Duward Shriver Willard Memorial Fund Edwin Przybylowicz Masanobu Yamauchi Taft Toribara John Yoke

Research Laboratory

Chemistry Building atrium

1988 Willard H. Teaching Dow Chemistry Laboratory Laboratory

20 1999 nal chemist and lives in West Chester, a nice note from his home in Oak Ridge Alumni PA. reminiscing about the period in the fifties Albert E. Taylor (PhD 1945, Willard) when Prof. Willard consulted for the Oak recently sent the Department a copy of his Ridge laboratories. Dr. Horton retired News from the Union Carbide Corp. in Oak Ridge. E-Mail: [email protected] Enver Mehmedbasich (BS 1954; PhD 1961, Wayne State U. (Organic)) retired from the Chevron Research & Technol- ogy Corp. in California and has moved to BEFORE 1940 Grand Junction, CO. Robert K. Mueller (MS 1935) has re- Roberta G. (Wood) Pourcho (BS 1954; tired from Arthur D. Little in Boston and PhD 1972, Wayne State U. (Anatomy)) is is now consulting. He is the author of a Professor of Anatomy and Cell Biology seventeen books on management and cor- in the Wayne State School of Medicine porate governance. and received the Gershenson Distin- Albert Taylor and Taft Toribara mak- guished Faculty Fellowship in 1997. David W. Stewart (PhD 1939, Fajans) ing preparations for a party at the Richard W. Robertson (BS 1950, MBA recalls that he was a post doc with Harold laboratory. Urey at Columbia Univ. from 1939 to 1957) has retired from the Dow Chemical 1941 engaged in isotope separation, a letter to Taft Y. Toribara (PhD 1942, Co. and moved to Florida. “hot” topic at the time. During WWII he Willard) in which he reminisces about Ellen S. (Eckwall) Schwartz (BS 1957; was Superintendent of Process Improve- their time in graduate school together. PhD 1970, Wayne State Univ. (Phys. ment on the Manhatten Project at Oak Dr. Taylor lives in Pocatello, ID. He Chem.)), is presently employed by Gen- Ridge and afterwards went to work for the retired from Idaho State University and eral Motors Research Laboratories where Eastman Kodak Co. from where he re- still does some cross country skiing at age she is a Senior Staff Research Scientist. tired as Head of the Analytical Labora- 90. Dr. Toribara recently retired as Pro- Bernard J. Sivak (BA 1950; MD, New tory in 1975. He still lives in Rochester, fessor of Biophysics and Toxicology at York Coll. of Med.) retired as Associate NY. His wife, Gretchen B. (Mueller) the University of Rochester Medical Cen- Professor and Adjunct Physician at Wayne Stewart (PhD 1940, Fajans) passed away ter. State University. in 1989. Horst D. Weinberg (BS 1949; MD 1953, Norman R. Smith (BSC 1955; JD, MS Howard E. Winters (MS 1938) retired U. of Chicago) has retired and is living in (Educ), PhD) is President of Catalytica, from Henry Ford Community College in Long Branch, NJ. Inc., in Mountain View, CA. Illinois in 1973. He writes and enjoys reading the news of the Department. Martha B. (Wells) Stiles (BS 1954) sent us the advance publication notice of her 1950 - 1959 first adult novel, “Lonesome Road”, which appeared in late 1998. She is the author of 1940 - 1949 Robert E. Bacon (BSC, BSE 1956; PhD ten books for juveniles. Her husband, R. 1960, MIT (Phys Chem)) has retired and Paul H. Cardwell (PhD 1941, F.E. is living in Darien, IL. Bartell) is living in Williamsburg, VA. Arthur C. Bond, Jr. (PhD 1952, Julius F. Chikos (BS 1949; DDS 1954, Brockway) recently moved from Dela- U. of Detroit) has retired from the prac- ware to Cary, NC. tice of dentistry and is living in Dearborn, Lyubica Dabich (BSC 1950, MD 1963) MI. has retired as Associate Professor from Andre S. Dreiding (PhD 1948, the Internal Medicine Department of the Bachmann) was honored by the Ameri- University of Michigan. She still lives in can Chemical Society in 1998 as a fifty Ann Arbor. year member. He is Professor Extraordi- Elmer S. Dupre (MS 1956) has retired nary at the University of Zurich. from Akzo Nobel Chemicals, Inc. and Martin Stiles on his Kentucky Helen G. (Shulman) Jaspen (BS 1943) moved to Florida. Thoroughbred farm has retired and moved to Bellevue, WA. David W. Emerson (PhD 1958, Smith) retired from the University of Nevada at Martin Stiles, was Professor of Chemis- Charles F. Krecke (BS 1948, MD 1953) try at Michigan from 1955 until 1979 and is retired and living in Pentwater, FL. Las Vegas last year. He is an active member of the regional accrediting com- is a former editor of the Journal of the Patricia G. (Bierregaard) Lavanchy (BS mittee and tutors in organic chemistry. American Chemical Society. 1943; MS 1946, Brooklyn Polytechnic) Clarence G. Thornton (BS 1949, PhD has retired from her position as a medici- Charles A. Horton (PhD 1950, Willard), one of Prof. Willard’s last students, wrote 1953, Brockway) retired as Director of

U-M DEPARTMENT OF CHEMISTRY 21 the Electronics and Power Sources Sec- John G. MacConnell (PhD 1969, Mar- tion of the U.S. Army Research Laborato- 1960 - 1969 tin) retired from Merck and Co. in 1993 ries in New Jersey. and is now living in rural North Carolina. Norman P. Arends (BS 1967) lives in Mary E. (Hall) Ware (MS 1956) retired France where he is an international con- Eugenia (Pann) Parcus (BS 1962; MD from the Grant-Blackford Mental Health sultant for medium and high tech compa- 1966, Med. Coll. of Pennsylvania) is a Hospital in Indiana as a therapist. nies in France and North America. pediatrician in private practice in Newtonville, MA. John E. Bauman (PhD 1962, Atkinson) ______retired as Professor of Chemistry at the Lowell R. McCoy (PhD 1967, H.B.Mark) University of Missouri/Columbia. He retired from Atomics International in Cali- The following alumni all were honored by teaches in summer institutes and assists fornia. the American Chemical Society in 1998 with alumni activities. as fifty year members: Lawrence C. Mitchell (BSC 1958, PhD Alan E. Brandt (BSC 1966, PhD 1972 1962, Smith) retired from Avery Interna- Donald R. Baer (PhD 1953, Smith) re- (Biochem)) moved Insect Biotechnology, tional Corp. in 1998, as Vice President tired from the Jackson Laboratory of the a company he cofounded and of which he and General Manager of the Engineered DuPont Co. is president, to North Carolina, near Re- Coatings Division. Max Boudakian (MS 1950; PhD 1955, search Triangle Park. Masayoshi Morimoto (PhD 1969, Purdue U.) was named “Inventor of the Yondani C.C. Butt (MS 1968; PhD) re- Overberger) has retired from the Kajima Year” by the Rochester Patent Law Assoc. ceived acclaim as an orchestral conductor Technical Research Institute in Japan and in 1981 and was employed by the Olin and musician. He is resident conductor of has accepted a position as Professor at Corporation. the Victoria International Festival in Purim in Kuala Lumpur, Malaysia. George F. Dasher (PhD 1950, F.E. Canada and has received numerous awards Leonard N. Schoenberg (PhD 1966, Bartell) retired from the Alberto-Culver for recordings made with the Royal Phil- Cooke) took early retirement from the Co., where he was vice president for re- harmonic and London Symphony Orches- Bell Laboratories and is now working for search and development. He lives in Ver- tras. Viasystems Technologies in New Jersey. mont. James H. Carter (PhD 1963, Smith) re- James M. Scofield (BSC 1968, MD 1972) Simon Frank (PhD 1951, Smith) retired tired from Barnard College of Columbia is a family practice physician in Glendale, from American Cyanamid Co. in 1985. University where he was Director of the CA. George G. Hazen (PhD 1952, Bachmann/ Organic Chemistry Laboratories. He has moved to Florida. Michael W. Stanton (BS 1968, MD 1972) Dreiding) retired from Merck Sharpe & is a cardiothoracic surgeon and president Dohme as Associate Director of their re- Dan G. Chapel (BSC, BSE 1960; MSE of the Northern Colorado Heart and Lungs search laboratories. 1962, U. of Southern Calif. (Chem. Eng.)) Clinic in Greeley. was recently promoted to Senior Vice Milton D. Heller (PhD 1952, Bachmann/ Janice R. (Bellinger) Ugolini (MS 1969) Dreiding) retired from Lederle Laborato- President of the Technology and Energy group at Fluor Daniel Corp. in Irvine, CA. is a senior programmer at Keane, Inc., in ries, a division of American Cyanamid New York. Co. He was a senior scientist engaged in David D. Dexter (BSC 1963; PhD 1968, chemical and clinical research. Georgetown Univ.) has moved to Basil H Vassos (PhD 1965, H.B. Mark) is Professor of Analytical Chemistry at the William B. Hillig (PhD 1954, Fajans) Earlysville, VA, in order to participate in the growing wine industry there. University of Puerto Rico, Rio Piedras. retired from the research laboratories of His wife, Aurora I. (Rincon) Vassos the General Electric Co. in Schenectady. Dolores G. (Novak) Eaton (MS 1967) is (BSC 1965) is an Associate Professor of Jerome P. Horwitz (PhD 1950, Smith) is president and CEO of Diagnostic Assay Chemistry there. a Professor of Hematology and Oncology Services, a clinical laboratory, in Mary- land. David S-N. Wang (BSC 1961) retired as at the Detroit Institute for Cancer Re- a supervisor from the Boeing Co. in 1998. search, associated with Wayne State Uni- David W. Ebdon (BSC 1961; PhD 1967, He now lives in California. versity. U. of Maryland) retired as Associate Dean Bruce H. Wark (PhD 1960, Elderfield) John T. Yoke, III (PhD 1954, Parry) is of the College of Sciences, Eastern Illi- nois University in Charleston. retired from Lehn and Fink Products Co., Professor Emeritus at the Oregon State a Division of Eastman Kodak, and is now University in Corvallis, OR. Bruce F. Hiscock (BSC 1962; PhD 1966, living in New Jersey. Masao Yoshimine (PhD 1956, Vaughan) Cornell Univ.) writes and illustrates retired as a research chemist for the Dow children’s books in Porter Corners, NY. Chemical Co. in Midland, MI. His most recent book is “The Big Rivers”. David R. Ingrum (BSC 1968, MD 1972) 1970 - 1979 is now a member of the Scripps Occupa- tional Health System in San Diego, CA. Samuel E. Backos (BSC 1978) lives in Clinton Township, Michigan, and is self Richard N. Loeppky (PhD 1963, Smith) employed. was named the first Schlundt Distin- guished Professor of Chemistry at the John E. Bercaw (PhD 1971, Brintzinger) University of Missouri/Columbia in 1998. was honored by the American Chemical

22 1999 Society with its 1999 George A. Olah University of Heidelberg, specializing in Jeffrey D. Peters (BS 1973; MBA 1980, Award for significant contributions to solid state NMR. Florida Inst. Technol.) is President and hydrocarbon chemistry. Dr. Bercaw is Arthur C. Guterl (PhD 1977, Overberger) CEO of the Interactive Pictures Corp. in Professor of Chemistry at the California retired from the Gencorp Polymer Prod- Lenoir City, TN. Institute of Technology. ucts Co. in June of 1997 and has moved to Irvin W. Potts, Jr., (PhD 1971, Stiles) is David A. Binstock (MS 1970; PhD Duke New Jersey. now R&D Director for the Dow Chemical Univ.) is a research chemist at the Re- Thomas J. Haas (MS 1976; MS 1981, Co. at their Lake Jackson, Texas installa- search Triangle Institute in North Caro- Rennselaer Polytechnic U. (Management); tion. lina. PhD 1987, U. of Connecticut) was re- Gregory R. Quinting (BSC 1979; PhD Peter J. Bonk (BSC 1975; PhD 1985, U. cently appointed Dean of Academics at 1985, Wisconsin) is involved in the appli- of Wisconsin) is a senior research devel- the U.S. Coast Guard Academy in New cation of NMR for educational purposes opment chemist for Abbott Laboratories. London, CT. with Anasazi Instruments, Inc., in India- napolis. Larry E. Brown (MS 1971; MD 1980, Steven W. Kaiser (PhD 1975, Rasmussen) Loyola Univ. of Chicago) is an emer- is Technology Manager in surfactants for Linda J. (Wolpert) Ray (MS 1971; MS gency medical physician at the Pullman the Union Carbide Corporation in West (Telecommunications)) manages techni- Memorial Hospital in the state of Wash- Virginia. cal publications for Lucent Technologies ington. Ruth E. Kelly (BSC 1979; PhD 1986, in Boulder, CO. William R. Buslee (MS 1979) is Vice Wayne State U.) is a staff scientist for David P. Richardson (BSC 1979; PhD President of Marketing for ReliaStar Life Bayer USA in California. 1984, U. of Calif./Berkeley) has recently Insurance Co. of New York. Jolanta (Jazwinski) Lott (BSC 1977, been promoted to full professor at Will- iams College in Massachusetts. Robert D. Chirico (PhD 1979, Westrum) BSE 1983) is a materials engineer for the has moved to the Washington, DC area Ford Motor Co. She writes that in her Steven C. Rifkin (BSC 1971; PhD 1976, where he will be a research chemist at the spare time she’s a soccer mom. Wisconsin) is senior principal consultant National Institute of Standards and Tech- John G. McGrew, II for the Oracle Corp. in New Jersey. nology. (PhD 1972, Green) is Thomas M. Rosseel Robert C. Dieterle (BSC 1975, MS 1979 Assoc. Professor of (BSC 1975; PhD 1981, (Bioengin.)) is the Senior Vice President Computer Science and U. of Wisconsin) has been and General Manager for the Cerner Corp. Dept. Chair at Carthage named Manager of the in Kansas. College in Wisconsin. Steel Irradiation Program in the Metals and Ceram- William D. Fetchik (BSC 1976; DO, Des Barry J. Meneghelli ics Division of the Oak Moines Coll. Osteopathic Med.) is a phy- (PhD 1977, Rudolph) Ridge National Labora- sician in Quarryville, PA. was recently honored for his role in the NASA tory. Thomas J. Giordano (PhD 1974; MBA Michael J. Sayers (BSC 1990, Colorado State U.) is a staff envi- Space Flight Awareness 1975; PhD 1980, MIT ronmental engineer concerned with water Program as an employee of Dynacs Engineering, (Phys. Chem.)) is an In- quality for the Lockheed Margin Astro- structor in technical train- nautics Co. in Inc., where he is a prin- ing for Navisys, Inc., in Denver. cipal investi- gator in their Edison, NJ. John A. Gladysz applied Vivian (Yang) Steger (BSC 1971; PhD chemistry Barry Meneghelli (BSC 1972) is living in 1974, Stanford) laboratory. San Diego and is a part has accepted the time teacher on the adjunct faculty of Chair of Organic Andrea B. Miller (BS 1978; National University. Chemistry at the MD 1998, McGill University, Canada) has completed her MD University of James H. Thirtle (PhD 1974, Dunn) re- Erlangen, degree and has accepted a po- tired after twenty years with the Dupont Nuremberg, Ger- sition in Tucson, Arizona. Corporation and is now a technical con- many, where he Anne E. Missavage (BSC sultant living in Rochester, NY. succeeds Paul von 1976; MD 1980, Wayne State Peter L. Thomas (BSC 1975, BSE 1978 Schleyer. John and Univ.) is a general surgeon liv- (Elec. Eng); PhD 1997, U. of Northern Janet Bluemel ing in Chesterfield, MO. Colorado (Educ.)) has accepted a teach- were married in Ronald V. Perkins (BS 1979; ing position at the University of Science December of MS, Calif. State Univ.) is a and the Arts in Chickasha, OK 1997. She holds a scientist employed by Thermo position as Asso- Michael Van der Puy (PhD 1975, Groves) Quest, a supplier of software is a Senior Principal Scientist for the Al- ciate Professor of for HPLC systems located in Chemistry at the lied Signal Corp. in Buffalo, NY. John Gladysz and Janet California. Bluemel

U-M DEPARTMENT OF CHEMISTRY 23 John T. Warsop (MS 1975) is a research Edward G. Ludwig (PhD 1984, Ashe) chemist for the Cyprus Foote Mineral has moved to Iowa City, IA. 1986 - 1989 Corporation in North Carolina. David P. Michelin (BS 1984, MS 1986 Richard N. Andrew (BS 1987, MBA David B. Whyte (BSC 1979; PhD 1987, (Pub. Health); MD 1990, Michigan State 1990) is a senior chemist with Ann Arbor U. of Calif./San Francisco (Biophys.)) is U.) is now a physician at the Munson Technical Services concerned with envi- a senior group leader in molecular gener- Medical Center in Traverse City, MI. ronmental waste water problems. ics for Sugen, Inc., in San Francisco. Mark O. Neisser (PhD 1981, Marino) has Christopher B. Bookout (BS 1986; MD William A. Wood, III, (BSC 1973; PhD left IBM and is now manager of deep UV 1990) is an orthopedic surgeon with the 1977, Univ. of Calif./Berkely; MS 1983, technology for Olin Microelectronic Ma- U.S. Navy stationed in Florida. Fuller Theological Seminary, (Divinity)) terials in Rhode Island. His wife, has accepted the post of pastor at the First Guillermina Avaria-Neisser (PhD 1984, Ruth A. Bucsh (MS 1986) has enrolled in Presbyterian Church of Santa Monica, CA. Groves) is a senior regional medical asso- a Clinical Research Administration pro- ciate for SmithKline Beecham. gram at Eastern Michigan University and Maw Sheng Wu (MS 1971, PhD 1976 is employed by the University of Michi- (Pharm. Chem.)) is Director of Product Paul J. Nowak (BSC 1982; MS) is an gan in their Cancer Center Clinical Trials. Development for the Bayer Co. in New Automotive Sales Manager at Engelhard Jersey. Corporation in Bay City, MI. Charles H. Chanpagne (MS 1989; MBA 1997, U. of Chicago) is a senior planner Jerome C. Pando (BS 1984; PhD 1989, with the Mobil Oil Corp. in Washington, West Virginia U. (Organic)) is a Senior DC. Projects Chemist for Merck & Company 1980 - 1985 in Pennsylvania. Mark A. Holmes (BSC 1987) is a re- search chemist with the Merck & Co. Sultan T. Abu-Orabi (PhD 1982, Ashe) Gary L. Parenteau (BS 1982, MD 1986) research laboratories in New Jersey. after two years as Visiting Professor at is a cardiac/thoracic surgeon in Toledo, Kira D. (Oswell) Hutchinson (BS 1986; King Fahd University in Saudi Arabia, OH. PhD 1990) is a Drug Sciences Officer at has returned to Yarmouk University in David P. Recker (Ex 1980, MD 1983) is DEA. She comments that life is some- Jordan where he is the Head of the Depart- Medical Director for Searle & Company what peaceful. ment of Chemistry. in Illinois. Ira Finkelstein (BS, BSE 1987; JD 1998) Andrew F. Childs (PhD 1985, Francis; Charles E. Schmidt (PhD 1980, Sacks) is an Associate with the law firm of Arnold, MD 1998, Univ. of Connecticut) has com- operates his own firm, C. E. Schmidt En- White and Durkee in Houston, TX. pleted his MD degree and is a resident in vironmental Consulting, in Red Bluff, CA. diagnostic radiology at the Yale-New Val S. Goodfellow (PhD 1986, Lawton) Haven Hospital. Olga I. Shamraj (BDC 1983; PhD 1994, is Project Team Manager for the Systems U. of Cincinnati (Mol. Biol.)) is an execu- Integration Drug Discovery Company, a Carl C. Correll (BSC 1984, PhD 1992 tive recruiter for the Madison-Davis Group subsidiary of Asahi Chemical and lives in (Biochem.)) has been appointed an Assis- in New York. Tucson, AZ. tant Professor in the Biochemistry/Mo- lecular Biology Department of the Uni- Marjorie S. Soloman (BSC 1983; PhD, Jeffrey A. Henchel (BS 1987) is a con- versity of Chicago and is engaged in es- Univ. of Washington) is a research scien- sultant to the automotive paint and plas- tablishing protein-RNA recognition prin- tist for Millennium Pharmaceuticals in tics industry and lives in North Carolina. Somerville, MA. ciples using X-ray crystallography and Kenneth J. Henry, Jr. (BSC 1987; PhD biophysical solution techniques. Birgit M. Stengren-Roy (BSC 1983) is a 1993, Indiana Univ.) accepted a position Thomas L. Cupps (PhD 1982, Townsend) molecular biologist with the Wyeth-Ayerst in drug discovery with Eli Lilly & Co. in is Associate Director of Chemical Devel- Research Laboratories in New Jersey. Indianapolis. His wife, Cynthia L. (Long) opment for Procter & Gamble Pharma- Gloria J. Stevens (BSC 1981; MD 1985, Henry (BSC 1987; MS 1990, Indiana ceuticals in Norwich, CT. Wayne State Univ.) is a dermatologist in Univ.) is enjoying raising their two young children. Barbara L. (Ruppel) De Clerck (BSC Upland, CA. and a Clinical Assistant Pro- 1983; MS 1993, U. of Oklahoma (Meteo- fessor at the University of Southern Cali- Carol A. (Laubach) Hoag (BS 1988) is rology)) writes that she is a “stay at home fornia. leading the commercialization of silicone mom,” in Fort Leavenworth, KS. Nguyen Van-Det (PhD 1980, Longone) rheology modifiers for the Dow Corning Company. Kathy J. (Dien) Hillig (PhD 1983, Mor- is a Senior R&D Associate with the B. F. ris) currently represents the chemical in- Goodrich Co. in Brecksville, OH. John C. Kacoyannakis (MS 1985; JD dustry on the EPA Environmental Advi- Ronald A. Voice (BS 1984, MS 1988 1990, Boston Univ.) is an attorney with sory Board and is employed at the BASF (Toxicology), MD 1992) is a physician/ Palmer & Dodge in Boston. Corporation in Wyandotte, MI. cardiologist in Okemos, MI. Julianne L. (Groh) Kampling (BSC, BSE Kevan R. Kreitman (BSC 1983; DPM 1987, MBA 1992) is Strategy and Alli- 1987, Pennsylvania Coll. of Podiatric ance Manager for the Amoco Oil Cmpany Medicine) is a podiatrist and owner of in Georgia. Kevan Kreitman DPM in Roseville, MI. James Ing Hui Lee (PhD 1989, Meyerhoff) is a Research Fellow in

24 1999 bioanalytical research with the Merck Pin-Pin Wu (MS 1985, PhD 1989, Filisko Matthew T. DesJardins (BS 1993; MD Corporation in Pennsylvania. (Macromol. Sci.)) is a principal plastics 1998, Wayne State Univ.) is a resident Ping Li (PhD 1989, Curtis) is a staff engineer for the Medtronic Interventional physician at the Wake Forest University engineer for Seagate Technology in Cali- Vascular Corporation in San Diego, CA. Baptist Medical Center in North Caro- fornia. lina. Daniel J. Link (BS 1988, MD 1992) is David J. Detlefsen (PhD 1990, Pecoraro) an anesthesiologist in Las Vegas, NV. is a senior research investigator in the 1990 – 1995 Pharmaceutical Research Institute of Josef K. Ludwig (BSC 1989; MBA 1995, Bristol-Myers Squibb in Pennsylvania. Ill. Inst. Technology) is principal chem- Saleem A. Al-Ahmad (PhD 1990, ist and coordinator for Lancaster Labo- Coucouvanis) is a research chemist with John M. Ellison (MS 1992) is Manager ratories in Lancaster, PA. the Lubrizol Corporation in Wickliffe, of Technical Publications for LifeScan, OH. Inc. in California. Norman J. Meluch (BSC 1987) is man- ager of Directory Services for the Gen- Valarie I. Benezra (BSC 1993; PhD 1998, Scott T. Fountain (PhD 1994, Lubman) eral Motors Corporation. MIT (Materials Sci.)) is employed as a is a senior scientist in the pharmacokinet- staff scientist by Choate Hall & Stewart in ics and metabolism division of Warner- Michael V. Milburn (BSC 1986; PhD Boston. Lambert Parke-Davis Co. in Ann Arbor. 1991, Univ. of Calif./Berkeley) is De- partment Head of Structural Chemistry Jason A. Berner (BSC 1994; MD 1998, Bin Fu (PhD 1994, Meyerhoff) is a senior at Glaxo Wellcome Inc., in North Caro- Wayne State Univ.) is a resident physi- scientist and group leader for the Bayer lina. cian in internal medicine at Emory Uni- Corporation in New York state. versity in Atlanta, GA. James S. Newhouse (PhD 1985, Brent M. Fuller (BSC 1993; MD 1997, Kopelman) is in Hawaii where he is se- Paul D. Boyce (BSC 1994; MD 1998, Wayne State Univ.) is a resident physi- nior scientist at the High Performance Emory Univ.) is a resident physician at cian at William Beaumont Hospital in Computing Center on Maui, associated the Emory University Medical School. Royal Oak. with the University of New Mexico. He Kelvin R. Bray (BSC 1994; MD 1998, Patricia F. (Yocum) Gaskamp (BS 1995) and his wife, Elizabeth (PhD 1986, Morehouse Univ.) is a resident physician is an English language teacher in Korea. Kopelman), recently adopted a Roma- at the Alton Ochsner Medical Foundation Ramesh Gopalaswamy (PhD 1993, nian orphan. Hospital in Louisiana. Koreeda) is a research chemist with Chris J. Noah (BSC 1987; MD 1994, Nicole M. Budrys (BSC 1993) is a vali- Glycosyn Pharmaceuticals, Inc., in Cary, Wayne State Univ.) is a family practice dation specialist with Baxter Healthcare NC. physician at the Midland (Michigan) Re- in Michigan. Eva J. Gordon (BS 1993; PhD 1998, gional Medical Center. Venus M. Buller (BS 1995) is self em- Univ. of Wisconsin/Madison) is a Andrew J. Patterson (BSC 1987; MD ployed and living in Virginia Beach, VA. Postdoctoral Fellow at the Harvard Medi- 1991, Emory Univ.) has joined the staff cal School. of Stanford University as a physician. Mark R. Burns (PhD 1993, Coward) is a senior scientist for the Oridigm Corp. in Daniel W. Grossman (MS 1993) is an Vassiliki Roulia (BSC 1986, MS 1988 Washington state. analytical chemist with the Diamond (Pharmacology); MBA 1997, U. of Vogel Paint Company in Iowa. Florida) is Program Manager of Clinical Benjamin M. Chien (PhD 1994, Lubman) is President and CEO of Quest Pharma- Carl W. Hahn (BS 1991; PhD 1997, Research Trials for the Neuroscience De- Princeton Univ.) is a senior chemist for partment at the University of Florida. ceutical Services located in Newark, Dela- ware. Nalco-Exxon Energy Chemicals in Ashis K. Saha (PhD 1986, Marino/Wuts) Sugarland, TX. Stephen S. Y. Cho (BS 1991) is a gradu- is a Principal Scientist for the Janssen Benjamin E. Haithcock (BS 1993; MD Research Foundation in Pennsylvania and ate student with Barry Trost at Stanford University. 1998, Michigan State Univ.) is now a is engaged in applying combinatorial resident in surgery at Henry Ford Hospi- chemistry in their Medicinal Chemistry Inchan Choi (PhD 1995, Kopelman) is a tal in Detroit. Department. Senior Research Chemist with Bisco Inc., in Naperville, IL. Michael D. Harvey (BS 1993) is a senior Kristi Ann (Dell) Snell (BSC 1989; PhD chemist for Ann Arbor Technical Ser- 1993, Purdue Univ.) is a research scien- Joe S. Chomchai (BSC 1990; MD 1994, vices. tist with Metabolix, Inc., in Massachu- Wayne State Univ.) is a physician spe- setts. cializing in otolaryngology at Central Laura M. Hoistad (PhD 1993, Lee) is an Michigan Community Hospital in Mount Assistant Professor of Chemistry at the Daniel J. Vargo (BSC 1987; MD 1992, University of Northern Iowa. Baylor Univ.) is a surgeon specializing Pleasant, MI. in trauma and critical care for the Uni- Julie Ann Church (BS 1993; MD 1997, Jeffrey D. Hsi (PhD 1990, Koreeda; JD, versity of California at Davis. Wayne State Univ.) is engaged in medical Rutgers Univ.) is a patent counsel with practice in Rochester Hills, MI. Kinetics Pharmaceuticals, Inc., of John R. Wagner (MS 1986; MD 1993, Medford, MA. St. Louis Univ.) is an orthopedic surgeon Konstantinos Demadis (PhD 1995) is with the Mayo Clinic in Rochester, MN. with the Nalco Chemical Co. in Naperville, IL.

U-M DEPARTMENT OF CHEMISTRY 25 Omar M. Javaid (BS 1995) consults for Jamey A. Nelson (BSC 1991; MS, Trin- Deloitte & Touche in Detroit. ity Lutheran Seminary (Divinity)) is a 1996 – 1999 pastor of the Faith Evangelical Lutheran Kirk W. Jobe (BSC 1993; MD 1997, Tracy L. (Rapp) Brice (PhD 1997, Mor- Church in Saginaw. Wayne State U.) is a resident in surgery at ris) works as a research chemist for the Wayne State. Gregory T. Randall (BS 1993, DDS Abbott Laboratories in Illinois. 1997) is a dentist in Berrien Springs, MI. Dennis H. Kim (BS 1995; MS 1998, E. Joseph Campbell (BS 1997) is at- UCLA) has entered the Albany Medical Pamela J. Riggs-Gelasco (PhD 1995, tending graduate school in Chemistry at College as a medical student. Penner-Hahn) is an Assistant Professor of Northwestern University. Chemistry at the College of Charleston, Will K. Kowalchyk (PhD 1995, Morris) Jiong “Jack” Chen (PhD 1998, South Carolina. Her husband, Andrew K. is an applications scientist with Kaiser Townsend) is doing research for Gelasco (PhD 1995, Pecoraro) is a re- Optical Systems in Ann Arbor. Pharmacia & Upjohn in Kalamazoo, MI. search scientist in pharmacology at the Traci J. Lee (BS 1993, PhD 1997 (Phar- Medical University of South Carolina in Wonyoung Choe (PhD 1998, Lee) is a macy)) is an Associate Drug Information Charleston. postdoctoral fellow at Iowa State Univer- Product Manager for SmithKline sity in Ames, IA. Michael R. Savina (PhD 1995, Francis) Beecham Pharmaceuticals in Pennsylva- Melvin C. Dacres (BS 1997) is employed nia. is an assistant chemist at the Argonne National Laboratory in Illinois. at the Detroit Waste Water Treatment Andrew K. Lesko (PhD 1994, Francis) plant as a junior chemist. Jason L. Schweitzer (BS 1995) is EDI works for Praegitzer Industries, Inc. in Sanmitra S. Deo (MS 1998) is with the Dallas, OR as Chemical Engineer Man- Coordinator for the Robert Bosch Foun- Advisory Board Company in Virginia. ager. dation in Chicago. Cathy L. (Lobach) Scott (BS 1994) was Michael W. Ducey, Jr. (PhD 1998, Thomas H-C. Li (BS 1992, MS 1994 Meyerhoff) is a Postdoctoral Research (Epidemiology); MD 1998, Wayne State a lab supervisor for the Cayman Chemical Associate at the University of Arizona in Univ.) is a resident physician in internal Co. but now lives in Dexter, MI. Tucson. medicine at the William Beaumont Hos- Karen E. (Ramos) Sexton (BSC 1995) is pital in Detroit. a Senior Assistant Chemist in medicinal Christopher A. Engel (BSC 1996) is a chemist with the Henkel Surface Tech- James H. Lindner (PhD 1990, (Chem. chemistry with the Parke-Davis Research Laboratories in Ann Arbor. nology Corp. in Michigan. Engin.), Postdoctoral 1991-4, Gland) is with the Environmental Protection Scott P. Sibley (PhD 1993, Francis) is an Kelly A. (Daly) Flynn (PhD 1998, Agency in Gainesville, FL. Assistant Professor of Chemistry at Penner-Hahn) is employed by Energy Goucher College in Maryland. He and Conversion Devices in Troy, MI. Bryan E. Little (BS 1994; MD 1998, Wayne State Univ.) is a resident orthope- Sharon M. Pan (BS 1992) were married Thaddeus H. Fox (BS 1998) is attending dic surgeon for Northwestern University. in 1998. graduate school in business at University Andreas I. Toupadakis (PhD 1990, of California-Berkeley. Larry J. Markosi (BS 1994) is an aca- demic professional with the University Coucouvanis) is a senior staff scientist at Alois M. Gerlach, Jr. (BSC 1997) is of Illinois in Urbana. the Lawrence Livermore National Labo- engaged in strategy and operations man- ratory in California. agement for the chemical industry at the Rachele A. Mastromatteo (BS 1995; Arthur D. Little Co. MS (Physical Therapy)) lives in Roseville, Gregory W. Wells (BSC 1993; PhD 1998, MI, where she is a physical therapist. Wayne State U.) is a senior research chem- Brent J. Hamstra (PhD 1998, Pecoraro) ist with the Wyckoff Chemical Co. in is a postdoctoral associate at the Univer- Randolph P. Matthews (BS 1990; PhD South Haven, MI. sity of Notre Dame, working with another 1996, MD 1998, Univ. of Washington) is Michigan graduate, Prof. Walter Scheidt a resident physician in pediatric medi- Mary Ann Wemple (BS 1991; MD 1995, Univ. of Washington) is a Rheumatology (PhD 1968). cine at the Childrens Hospital of Phila- delphia. Fellow at the University of Washington Ramy A. Hassan (BS 1998) is a Drug Medical Center in Seattle. Safety Coordinator for the Parke-Davis Shahid M. Maturza (BS 1994) is a gradu- Zhifu Xu (PhD 1992, Moore) is a senior Pharmaceutical Co. ate in chemistry at Pennsylvania State University. research scientist with S. C. Johnson & Brent H. Hilbert (MS 1997) is a chemist Son, Polymer Division, in Racine, WI. with Beckman & Coulter in Chaska, MN. Brett T. Mercer (BS 1993) is pursuing Louis K. Zweig (BS 1992; MD 1996, an MBA degree at Purdue University. Tracy M. Hobson (BS 1998) is an asso- Ohio State U.) is a physician at ciate scientist with the DuPont Pharma- Patrick E. Mosier (PhD 1995, Georgetown University in Washington, ceutical Co. in Wilmington, DE. Coucouvanis) works for B.P. Chemicals DC. in Ohio as a SeniorAssociate engaged in Shirley M. Hoenigman (PhD 1998, C. E. catalyst research. His wife, Gayatry Evans) is an Assistant Professor of Chem- Jacob-Mosier (PhD 1995, Lawton) is istry at Newman University in Witchita, raising their two daughters, ages 5 and 1. KS.

26 1999 Heather L. (Smith) Holmes (PhD 1998, Cola Co. in New York State. His wife, Karen E. (Guzdial) Spiteri (BSC 1996) Sacks) is an Assisant Professor of Chem- Elizabeth Todd Milne (PhD 1996, Mor- works as a research chemist in the New istry at Eastern Michigan University. ris) is a self employed technical writer. Technologies Division of ND Industries Maria Jancevski (BS 1998) is a graduate Anil Mitra (BSC 1997) is an associate near Detroit. student in basic medical sciences. chemist at Dupont-Merck in Philadelphia. Tresa M. Staeven (BSC, BSE 1997) is a Nancy L. Jestel (PhD 1998, Morris) is a Brian T. Molenda (BS 1997) is working report coordinator for Weyco, Inc., in research chemist for the General Electric as a bench chemist with Philips Industrial Grand Rapids. Co., Plastics Division. Services in Detroit. Joseph W. Styrna (BS 1998 (Chem., Sarah L. Jouppi (BSC 1996; MS 1998, Michael Molinier (Postdoctoral 1998, Econ.)) runs his own investment office in Univ. of Massachusetts) is a senior re- Curtis) is a research chemist with the Walled Lake, MI as an affiliate of Edward search associate with CombiMatrix Corp. Allied Signal Environmental Catalyst Jones Investments. in Santa Clara, CA. Corp. in Tulsa, OK. Jack R. Waas (PhD 1997, Ashe) will be Ricky Tsz Lam Li (BSC, BSE 1997) is a Ramasubramanian Narayanan (PhD starting a tenure track position at Bethel member of the technical staff for Lucent 1998, Laine) is a research chemist for College in Arden Hills, MN, in the fall of Technologies in New Jersey. TAL Materials in Ann Arbor. 1999. David J. Lieberman (BS 1998) is a re- Carolyn E. Owen (BS 1998) is attending Patrick A. Walker, III (PhD 1998, Mor- search chemist with the Great Lakes graduate school in chemistry at the Uni- ris) is a senior scientist with Betz Dearborn Chemical Co. in West Lafayette, IN. versity of California-Irvine. in Pennsylvania. Kyle E. Litz (PhD 1998, Banaszak-Holl) Adarsh D. Pandit (BS 1998) works at the Brent W. Warner (MS 1996; MS 1997, has accepted a position as a staff chemist Brigham and Women’s Hospital in Bos- West Virginia Univ. (Safety Manage- with the General Electric Corp. in ton, MA. ment)) is working for the Dick Corpora- tion as a safety representative. Schenectady, NY. James D. Pennington (PhD 1998, Honjun Liu (PhD 1998, Sension) is a Koreeda) is a Lecturer and Postdoctoral Robb J. Wilson (PhD 1998, Kuczkowski) Research Assistant at the Scripps Re- Scholar at Texas A&M University in Col- has accepted a tenure track position as search Institute in La Jolla, CA. lege Station, TX. Assistant Professor of Physical Chemis- try at Louisiana State University at Shreve- Hui Liu (PhD 1997, Rasmussen) is a Moira C. Ringo (PhD 1999, CE Evans) port. Senior Application Chemist at Solutia, will be a research chemist in their analyti- Inc., in Springfield, MA. cal sciences division with the Glaxo- Jinhai Yang (PhD 1998, Koreeda) is a Wellcome Corp. in New Jersey. Postdoctoral Fellow at the Pensylvania M. Adnan Mansour (PhD 1996, Curtis) State University. is a Postdoctoral Associate with Elf Dell T. Rosa (PhD 1998, Coucouvanis) is Atochem North America, Inc. in their continuing as a postdoctoral scholar at the Shuliang Zhang (PhD 1994, Univ. of strategic research division. University of Michigan. Alberta; Postdoc 1997, Morris) has ac- cepted a position as a research scientist Leah M. Meeuwenberg (MS 1998) is a Arif M. Sitabkhan (BSC 1998) has joined with Unilever Research in New Jersey. failure analysis engineer for Smartflex Blue Coral-Slick 50 in Westlake, OH, as Systems in Tustin, CA. a R&D chemist. Valentin R. Zhelyaskov (PhD 1989, Sofia Univ.; Postdoctoral 1996, Morris) is a Paul Milne (PhD 1996, Lubman) is a John P. Snow (BS 1998) is a Research senior scientist with World Precision In- Senior Research Specialist for the Pepsi Associate at the University of Michigan. struments in Sarasota, FL.

U-M DEPARTMENT OF CHEMISTRY 27 In Memoriam

We were sorry to learn of the deaths of ences and Humanities at Iowa State Uni- Administration in Washington, DC, at the following alumni, alumnae and versity, where he had taught for 40 years; the time of his death. friends of the Department. a former Chair of the Chemistry Depart- Rees T. Makins (MS 1937) died July 7, ment, he had also served as Director of the 1998 in Deerfield Beach, FL. He founded AEC Ames Laboratory. His area of re- M-W Laboratories of Chicago, an elec- David B. Andrews (PhD 1938, search was surface chemistry, particu- troplating company. He retired in 1986 Schoepfle) died September 16, 1997, in larly adsorption, catalysis, interfacial ten- and moved to Florida. Maryville, TN. Dr. Andrews retired from sion and structure. the Koppers Company as Vice President Terrell C. Myers (PhD 1952, Bachmann/ Raymond E. Hoffman, Jr. (BSC 1965, of their International Division. Prior to Dreiding) died August 6, 1997 in Chi- MD 1969) died unexpectedly July 23, that he was employed at the General cago. He had been a Professor of Bio- 1997 from a cardiac arryhmia. He was a Aniline Company, leaving in 1959. He chemistry at the University of Illinois practicing surgeon with the Rockford Sur- was the first chairman of the Air Quality Medical Center in Chicago. Commission of the Manufacturing Chem- gical Service in Rockford, IL. He is sur- Donald O. Niederhauser (PhD 1947, ists Association. vived by his wife Nancy and their two children. F.E.Bartell) died July 20, 1997 in Stanton, Karen G. (Kammann) Cuneo (BSC/ DE. He retired from the Textile Division Teresa C. Hsu (BS 1998) passed away on BSE 1985) passed away March 18, 1996 of the DuPont Co. where he was a senior May 5, 1999, while a student at the Cali- in Albuquerque, NM. She was previ- research supervisor and had generated fornia Institute of Technology in Pasa- ously employed at Honeywell Defense 12 patents during his career. In the 1960’s, dena, CA. Avionics Corp. he had led a successful drive for the Robert O. Eberbach (BS 1937) died in Charles K. Hunt (PhD 1934, Schoepfle) reapportionment of the General Assem- Ann Arbor on June 27, 1999. Mr. died March 24, 1998, in Hinsdale, IL. He bly in Delaware. was an Emeritus Professor of Chemistry Eberbach was a member of the family Ralph W. Raiford (PhD 1955, Halford) at the University of Illinois, Chicago. Prior that owned the Eberbach Scientific Co. died in Ann Arbor February 19, 1999. to his academic career he worked for the which, for many years, was the supplier After a period in industry, Ralph super- Mellon Institute, Gulf R&D Corp., Pitts- of scientific apparatus and chemicals to vised the University of Michigan Chem- burgh Plate Glass Co., and Sharples the University. istry Store until its close, moving to Gen- Chemical Co., where he was a research eral Stores until his retirement Henry C. Godt, Jr. (PhD 1953 (Pharm. director. He served as Chair for both the Chem.)) died January 29, 1998 in St. Detroit and Chicago Section of the Ameri- Esther M. Rice (MS 1931), one of our Louis, MO. He retired from Monsanto can Chemical Society. older alumnae, died March 12, 1999, in Chemical Co. having spent his entire Dallas, TX. career with that company. His area of Walter E. Kester (BS 1950) died Decem- James E. Scott (BS 1940) died Novem- research was the oxidation of ber 17, 1996 in Midland, MI. He was a ber 22, 1998 in Minneapolis, MN. After cyclohexanol to adipic acid and the de- member of the analytical research depart- graduation, he joined the General Elec- velopment of new insecticides. In 1970, ment of the Dow Chemical Co. for 31 tric Co. and then, after the war, the he became the technology appraisal man- years when he retired in 1982. Nuclear Materials and Equipment Corp. ager and was involved in the evaluation Beatrys L. A. (DeSmet) Kolaitis (MS where he specialized in spectrographic of the environmental impact of the 1984) died unexpectedly at age 37 in analysis of nuclear materials. Later he company’s products and collection of the Meise, Belgium, on June 18, 1998. She was involved in combustion engineering data necessary to submit to the govern- had been a Product Development Man- and retired as supervisor of analytical ment to satisfy the Toxic Substances Con- ager with Procter & Gamble in Brussels. services. His son, David and David’s trol Act. She leaves her husband, Leonidas Kolaitis wife, Andrea, both Michigan alums have (PhD 1987, Lubman), and two children, Ira E. Halt, Jr. (BSC 1948) died No- established an endowment to fund the ages 6 and 3. vember 3, 1997, in Chesterland, OH. He Scott-Larsen Professorship in Chemistry retired from the Lamp Division of the Robert E. Machol (PhD 1958, Westrum) in honor of their parents. Andrea’s father General Electric Co. in Cleveland. died on November 12, 1998. He had left is John A. Larsen, a graduate of the Uni- Robert S. Hansen (PhD 1948, FE Bartell) the field of chemistry and held the post of versity in Civil Engineering. chief scientist for the Federal Aviation died June 16, 1998 in Ames, IA. He was Walter J. Warzybok (BS 1967) died Emeritus Distinguished Professor of Sci- September 22, 1998 in Hamtramck, MI.

28 1999 Gary D. Glick, Werner Bachmann Profes- William H. Pearson, Professor. Synthetic sor. Bioorganic Chemistry, Molecular Organic Chemistry. FACULTY Recognition. Vincent L. Pecoraro, Professor. Synthetic Richard A. Goldstein, Associate Professor Inorganic and Bioinorganic Chemistry. and Research Scientist, Chemistry and James E. Penner-Hahn, Professor. Bio- Biophysics Research Division. Compu- physical Chemistry and Inorganic Spec- Arthur J. Ashe III, Professor. Organome- tational Molecular Biophysics, Physical troscopy. tallic Chemistry. Chemistry. A. Ramamoorthy, Assistant Professor and Mark M. Banaszak Holl, Associate Profes- Adon A. Gordus, Professor. Radioanalytical- Research Scientist, Chemistry and Bio- sor. Synthetic and Mechanistic Solu- Radiation Chemistry. physics Research Division. Structural tion, Surface, and Solid State Chemistry. Henry C. Griffin, Professor. Nuclear Chem- Studies of Biological Molecules. John R. Barker, Professor, Chemistry and istry: Gamma-Ray Spectroscopy of Paul G. Rasmussen, Professor. Polymer/ Atmospheric, Oceanic and Space Sci- “Hot” and “Cold” Nuclei. Inorganic Chemistry. ences. Chemical Kinetics, Atmospheric Nancy K. Kerner, Lecturer, Coordinator of William R. Roush, Warner Lambert/Parke Chemistry. General Chemistry Laboratory. Chemi- Davis Professor. Organic Chemistry. Larry W. Beck, Assistant Professor. Ana- cal Education : Learning and Instruc- Richard D. Sacks, Professor. High Speed lytical NMR spectroscopy of Materials; tional Methods. Analytical Separations. Zeolite Catalysis. Raoul Kopelman, Kasimir Fajans Profes- Roseanne J. Sension, Associate Professor. Mary Anne Carroll, Associate Professor, sor. Chemistry, Applied Physics, and Physical Chemistry, Ultrafast Laser Spec- Chemistry and Atmospheric, Oceanic Physics. Analytical/Physical/Biophysi- troscopy. cal Chemistry. and Space Sciences. Atmospheric Chem- Robert R. Sharp, Professor. Multidimen- istry. Masato Koreeda, Professor. Chemistry and sional and Multiquantum NMR of Para- Brian P. Coppola, Associate Professor, Or- Medicinal Chemistry, Synthesis of Natu- magnetic Systems. ganic Chemistry. Coordinator of Un- ral Products. Small Molecule-DNA In- teraction, Chemical Carcinogenesis, Leroy B. Townsend, Professor, Medicinal dergraduate Organic Chemistry Curricu- Chemistry and Chemistry. Design Syn- Glycobiology. lum. Science Learning and Instructional thesis and Biological Evaluation of Het- Methods. Robert L. Kuczkowski, Professor. Micro- erocycles and Nucleosides. Gene H. Cordes, Professor, Chemistry and wave Spectroscopy of Weakly Bonded Complexes. Edwin Vedejs, Moses Gomberg Professor. Medicinal Chemistry. Molecular De- Organic Chemistry. sign; Enzymatic Reaction Mechanisms; Richard M. Laine, Associate Professor, Ma- Nils G. Walter, Assistant Professor. Chemi- Biochemistry. terials Science and Engineering and cal Biology. Dimitri Coucouvanis, Professor. Synthesis, Chemistry. Materials Chemistry. Barbara J. Weathers, Lecturer, and Lec- Structures and Reactivities of Metal Clus- Richard G. Lawton, Professor. Organic ters and Supramolecules. Chemistry. turer in Comprehensive Studies Program. John R. Wiseman, Professor. Synthetic Or- James K. Coward, Professor, Medicinal Lawrence L. Lohr, Professor. Theoretical Chemistry and Chemistry. Bioorganic Studies of Molecular Structure and Re- ganic Chemistry and Mechanisms of Chemistry and Medicinal Chemistry. activity. Chemical Reactions. M. David Curtis, Professor. Organometal- David M. Lubman, Professor. Biological Omar Yaghi, Professor. Materials Chemis- lic and Conducting Polymers. Mass Spectrometry, Spectroscopy and try. Seyhan N. Ege, Professor. Heterocyclic Re- Instrumentation. Charles F. Yocum, Professor, Biological active Intermediates. Joseph P. Marino, Professor and Chair. Sciences and Chemistry. Biological Chemistry of Photosynthesis. B. J. Evans, Professor. Solid State Chemis- Chemistry and Medicinal Chemistry. try: Electronic and Magnetic Materials. New Synthetic Methods and Strategies Edward T. Zellers, Associate Professor, for Natural Product Synthesis. Chemistry and Environmental and In- Christine E. Evans, Assistant Professor. Ana- dustrial Health. Environmental-Analyti- lytical/Physical Chemistry. E. Neil G. Marsh, Assistant Professor. En- zymes: Structure, Mechanism, and Speci- cal Chemistry. Carol Fierke, Professor, Biological Chemis- Erik R. P. Zuiderweg, Professor, Chemistry try. ficity; Protein Engineering and Molecu- lar Recognition. and Biophysics. NMR Studies of Anthony H. Francis, Arthur F. Biomacromolecular Conformation and Mark E. Meyerhoff, Professor. Bioanalytical ThurnauProfessor. Magnetic Resonance, Dynamics in Solution. Vibrational and Electronic Spectroscopy Chemistry, Electrochemical and Opti- of Materials. cal Sensors. Professors Emeriti: Lawrence S. Bartell, S. John L. Gland, Professor, Chemistry, Chemi- Michael D. Morris, Professor. Analytical Laser Spectroscopy and Imaging; Elec- M. Blinder, Thomas M. Dunn, Daniel cal Engineering, and Applied Physics. T. Longone, Christer E. Nordman, Solid State and Surface Chemistry, Physi- trophoretic Separations. Kathleen V. Nolta, Lecturer III. Organic Lawrence J. Oncley, Peter A. S. Smith, cal Chemistry. Milton Tamres, Robert C. Taylor, Biochemistry. Edgar F. Westrum, Jr.

U-M DEPARTMENT OF CHEMISTRY 29 Gomberg 2000 Conference VIIIth International Symposium on Organic Free Radicals June 25 – 29, 2000

University of Michigan, Ann Arbor, Mi

Contact Masato Koreeda, [email protected] Web: http://www.umich.edu/~michchem/gomberg/2000

1900 2000

The VIIIth International Symposium on Organic Free Radicals will be held June 25-29, 2000 in Ann Arbor, Michigan. This symposium will celebrate 100 years since Moses Gomberg’s publication on triphenylmethyl. The conference will emphasize all aspects of organic radicals – mechanism and theory, synthesis, free radicals in Biology and Polymers.

16th biennial conference on chemical education BCCE lighting the way to the future C H 2000MM University of Michigan M Ann Arbor, Michigan E D July 30 – August 3, 2000

Supported by: Warner-Lambert Parke-Davis Dow Chemical Company General Motors Corporation 3M Corporation Pharmacia & Upjohn World Heritage Foundation • American Chemical Society, Detroit Section Department of Chemistry, University of Michigan • Division of Chemical Education, American Chemical Society

Contact Rich Rothrock (734) 763-9069 E-mail: [email protected] Web: http://www.umich.edu/~bcce 30 1999 Alumni-Alumnae Reply Form Please complete and return this form for our alumni files; include news of your current activities or suggestions for the next Newsletter:

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