Author Manuscript Published OnlineFirst on May 14, 2019; DOI: 10.1158/2326-6066.CIR-18-0500 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients Joseph Cursons1,2,†, Fernando Souza-Fonseca-Guimaraes2,3,†, Momeneh Foroutan1,4, Ashley Anderson1, Frédéric Hollande4, Soroor Hediyeh-Zadeh1, Andreas Behren5,6, Nicholas D. 2,3,7 , 1,2,8, , Huntington ^ *, Melissa J. Davis ^ * 1 Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research. Parkville, Victoria 3052, Australia 2 Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia 3 Division of Molecular Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia 4 Department of Clinical Pathology, The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, Victoria 3000, Australia 5 School of Cancer Medicine, La Trobe University, Melbourne, Victoria 3086, Australia 6 Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia 7 Biomedicine Discovery Institute and the Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia 8 Department of Biochemistry, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3010, Australia †,^ Authors have contributed equally to this work * Corresponding Authors Key words: natural killer cell, gene set scoring, TGFβ, transforming growth factor β, phenotype-switching, melanoma survival Running title: A gene signature for NK infiltration and melanoma survival Corresponding author contact details: Prof. Nicholas D Huntington Dr Melissa J Davis
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