DOCSLIB.ORG

EGE TIP DERGİSİ / EGE JOURNAL of MEDICINE Ege Üniversitesi Tıp Fakültesi Resmi Yayın Organıdır

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
EGE TIP DERGİSİ / EGE JOURNAL of MEDICINE Ege Üniversitesi Tıp Fakültesi Resmi Yayın Organıdır ISSN 1016 - 9113 EGE TIP DERGİSİ / EGE JOURNAL OF MEDICINE Ege Üniversitesi Tıp Fakültesi Resmi Yayın Organıdır. The Official Publication of Ege University Faculty of Medicine. Cilt / Volume: 58 Ek Sayı / Supplement Ekim / October 2019 Sayfa / Pages: 1-74 Editör / Editor Okan BĠLGE - Ege Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı / Dept. of Anatomy, Ġzmir, Türkiye Ege Üniversitesi Tıp Fakültesi Yayın Kurulu / Publication Committee of Ege University Faculty of Medicine AyĢegül AKGÜN - Nükleer Tıp Anabilim Dalı / Dept. of Nuclear Medicine, Ġzmir, Türkiye Gül AKTAN - Çocuk Sağlığı ve Hastalıkları Anabilim Dalı / Dept. of Pediatrics, Ġzmir, Türkiye Raika DURUSOY - Halk Sağlığı Anabilim Dalı / Dept. of Public Health, Ġzmir, Türkiye Yusuf ÖZBEL- Tıbbi Parazitoloji Anabilim Dalı / Dept. of Medical Parasitology, Ġzmir, Türkiye Semra KARAMAN - Anesteziyoloji ve Reanimasyon Anabilim Dalı / Dept. of Anestesiology and Reanimation, Ġzmir, Türkiye Gülgün KAVUKÇU - Radyodiagnostik Anabilim Dalı / Dept. of Radiodiagnostics, Ġzmir, Türkiye Altuğ YAVAġOĞLU - Histoloji ve Embriyoloji Anabilim Dalı / Dept. of Histology and Embryology, Ġzmir, Türkiye Biyoistatistik Uzmanları / Biostatistician Timur KÖSE - Ege Üniversitesi Tıp Fakültesi, Bioistatistik ve Tıbbi BiliĢim Anabilim Dalı / Ege University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Ġzmir, Türkiye Mehmet N. ORMAN - Ege Üniversitesi Tıp Fakültesi, Bioistatistik ve Tıbbi BiliĢim Anabilim Dalı / Ege University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Ġzmir, Türkiye Uluslararası Editör ve Danışma Kurulu / International Editors and Advisory Board AyĢe Nur OKTAY ALFATLI - Ege University Faculty of Medicine, Dept. of Radiodiagnostics, Izmir, Turkey Juzar ALI - LSU Health Care Network Clinics & Interim LSU Hospital Clinics, Chief Medical Officer, New Orleans, United States J Patrick BARBET - University of Paris Descartes AP, Dept. of Anatomy, Histology and Embryology, Paris, France Ali BAġÇI - Ege University Faculty of Medicine, Dept. of Internal Medicine, Izmir, Turkey Mustafa ÇIKIRIKÇIOĞLU - University Hospitals of Geneva, Division of Cardiovascular Surgery, Geneva, Switzerland Stephen KANTROW - Louisiana State University School of Medicine, Associate Professor of Medicine, New Orleans, Louisiana, United States Jose A. KARAM - MD Anderson Cancer Center, Dept. of Urology, Texas, United States Eduardo Weruaga PRIETO - Universidad de Salamanca, Instituto de Neurociencias de Castilla y León, Lab. Plasticidad Neuronal y Neurorreparación Dpto. Biología Celular y Patología, Salamanca, Spain Metin ÖZDEMĠRLĠ - Medstar Georgetown University Hospital, Dept. of Pathology, Washington D.C., United States Hasan TEKGÜL - Ege University Faculty of Medicine, Dept. of Pediatrics, Izmir, Turkey Tarık TIHAN - University of California San Francisco, Dept. of Pathology, California, United States Utku YAVUZ - Bernstein Center for Computational Neuroscience, Dept. of Orthobionic / Dept. of Neurorehabilitation Engineering, Göttingen, Germany Yazışma Adresi / Address for Correspondence : Hülya SEZGĠN, Ege Üniversitesi Tıp Fakültesi Yayın Bürosu, Bornova 35100, Ġzmir, Türkiye Telefon / Phone : +90 232 390 31 03 E-posta / E-mail : [email protected] Web adresi / URL : www.egetipdergisi.com.tr / www.dergipark.gov.tr/etd T.C. Kültür ve Turizm Bakanlığı / Republic of Turkey Ministry of Culture and Tourism Sertifika / Certificate No. 18679 Basım / Press Ege Üniversitesi Rektörlüğü Basımevi Müdürlüğü No: 172/134 Kampüs içi Bornova – ĠZMĠR Tel: 0232 311 18 19 e-mail: [email protected] Basım Tarihi / Date of Press 25.10.2019 Yıllık abone ücreti 100 TL, tek sayı bedeli 25 TL’dir. The annual subscription fee is 100 TL, the single issue fee is 25 TL. Abone ve tek sayı istekleri için [email protected] adresine mesaj gönderebilir ya da 232.3903103 / 232.3903186 numaralı telefonu arayabilirsiniz. For annual subscription or single issue requests, you may mail to [email protected] or you may call +902323903103 / +902323903186 Bu sayıda yer alan tüm yazarların ORCID (Open Researcher and Contributor ID) bilgisine web adresinde makalenin elektronik kopyasında yazar adı üzerindeki simgesine tıklanarak eriĢilebilir. ORCID (Open Researcher and Contributor ID) information of each author in this issue can be obtained by clicking the icon above the author name through the electronic copy of the manuscript on the web site. Ege Tıp Dergisi / Ege Journal of Medicine 2019: 58; Ek Sayı / Supplement Değerli Okuyucu, İlki 1991 yılında yapılan, sonra her iki yılda bir düzenlenmeye devam edilen ve ulusal anlamda en eski romatoloji toplantılarından birisi olan Ege Romatoloji Günleri’nin on beşincisini 15-18 Kasım tarihleri arasında Denizli’de düzenledik. Bilimsel içeriği ve konuların işlenme şekli ile romatolojinin farklı alanlarına ilgi duyan tüm hekimlerimize yönelik bir toplantı gerçekleştirdik. Bu toplantıda tartışılan konuların daha geniş kitlelere ulaşabilmesi için Ege Tıp Dergisi Ek Sayısı çıkarmaya karar verdik. Bu sayıya katkıda bulunan tüm yazarlara ve emeği geçenlere çok teşekkür ediyorum. Ek sayının ilgili hekimlere faydalı ve yol gösterici bir kaynak olmasını diliyorum. T.C. Kültür ve Turizm Bakanlığı / Republic of Turkey Ministry of Culture and Tourism Sertifika / Certificate No. 18679 Doç. Dr. Gonca Karabulut Basım / Press Romatoloji Ek Sayısı Misafir Editörü Ege Üniversitesi Rektörlüğü Basımevi Müdürlüğü Ekim 2019 No: 172/134 Kampüs içi Bornova – İZMİR Tel: 0232 311 18 19 e-mail: [email protected] Basım Tarihi / Date of Press 20.10.2019 Yıllık abone ücreti 100 TL, tek sayı bedeli 25 TL’dir. The annual subscription fee is 100 TL, the single issue fee is 25 TL. Abone ve tek sayı istekleri için [email protected] adresine mesaj gönderebilir ya da 232.3903103 / 232.3903186 numaralı telefonu arayabilirsiniz. For annual subscription or single issue requests, you may mail to [email protected] or you may call +902323903103 / +902323903186 Bu sayıda yer alan tüm yazarların ORCID (Open Researcher and Contributor ID) bilgisine web adresinde makalenin elektronik kopyasında yazar adı üzerindeki simgesine tıklanarak erişilebilir. ORCID (Open Researcher and Contributor ID) information of each author in this issue can be obtained by clicking the icon above the author name through the electronic copy of the manuscript on the web site. Ege Tıp Dergisi / Ege Journal of Medicine 2019; 58: Ek Sayı / Supplement İÇİNDEKİLER (CONTENTS) TNF-Alfa inhibitörleri ıle tedavi seyrinde gelişen alerjik reaksiyonlar Hypersensitivity reactions to TNF-Α inhibitors Sevim Bavbek 1 Anti-TNF tedavisi seyrinde gelişen üveitler: primer hastalıktan mı ilaçtan mı? Uveitis under anti-TNF therapy: Adverse effect or disease course? Didem Arslan 6 Anti-TNF tedavi seyrinde gelişen otoimmün hastalıklar: Eşlik eden hastalık mı? İlaca mı bağlı? Autoimmune diseases during anti-TNF therapy: Coexisting disease? Drug-induced? Selda Çelik 8 Biyolojik ajanların pulmoner komplikasyonları Pulmonary complications of biological agents M. Sezai Taşbakan 11 Osteoartrozda yeni tedavi yöntemleri New therapy methods in osteoarthritis Diren Özer Sibel Eyigör 14 Romatizmal ağrıların palyasyonunda girişimsel ağrı tedavisi yöntemleri Interventional pain treatment modalities in palliation of rheumatic pains İdris Şevki Köken Can Eyigör 22 Hastalığı modifiye eden antiromatizmal ilaçlarla etkileşimler bakımından analjezik ilaçların akılcı kullanımı Rational use of analgesics with regard to the interactions with disease-modifying anti-rheumatic drugs Aytül Önal 27 İmmun checkpoint inhibitörleri ilişkili bağ dokusu hastalıkları Immune checkpoint ınhibitors related connective tissue diseases Ayten Yazıcı 34 Romatolojik hastalıklarda fibromiyaljinin payı The role of fibromyalgia in rheumatic diseases Arzu On 38 Fibromiyaljide güncel ilaç tedavisi Current drug treatment in fibromyalgia Seval Pehlevan 43 Psoriatik artritin tedavisinde yeni ilaçlarin karşılaştırması The comparison of new biologic treatments in psoriatic arthritis Figen Yargucu Zihni 48 Ege Tıp Dergisi / Ege Journal of Medicine 2019; 58: Ek Sayı / Supplement İÇİNDEKİLER (CONTENTS) TNF-Alfa inhibitörleri ıle tedavi seyrinde gelişen alerjik reaksiyonlar Hypersensitivity reactions to TNF-Α inhibitors Sevim Bavbek 1 Anti-TNF tedavisi seyrinde gelişen üveitler: primer hastalıktan mı ilaçtan mı? Uveitis under anti-TNF therapy: Adverse effect or disease course? Didem Arslan 6 Anti-TNF tedavi seyrinde gelişen otoimmün hastalıklar: Eşlik eden hastalık mı? İlaca mı bağlı? Autoimmune diseases during anti-TNF therapy: Coexisting disease? Drug-induced? Selda Çelik 8 Biyolojik ajanların pulmoner komplikasyonları Pulmonary complications of biological agents M. Sezai Taşbakan 11 Osteoartrozda yeni tedavi yöntemleri New therapy methods in osteoarthritis Diren Özer Sibel Eyigör 14 Romatizmal ağrıların palyasyonunda girişimsel ağrı tedavisi yöntemleri Interventional pain treatment modalities in palliation of rheumatic pains İdris Şevki Köken Can Eyigör 22 Hastalığı modifiye eden antiromatizmal ilaçlarla etkileşimler bakımından analjezik ilaçların akılcı kullanımı Rational use of analgesics with regard to the interactions with disease-modifying anti-rheumatic drugs Aytül Önal 27 İmmun checkpoint inhibitörleri ilişkili bağ dokusu hastalıkları Immune checkpoint ınhibitors related connective tissue diseases Ayten Yazıcı 34 Romatolojik hastalıklarda fibromiyaljinin payı The role of fibromyalgia in rheumatic diseases Arzu On 38 Fibromiyaljide güncel ilaç tedavisi
Load more

Recommended publications
  • Summary Analgesics Dec2019
    Status as of December 31, 2019 UPDATE STATUS: N = New, A = Advanced, C = Changed, S = Same (No Change), D = Discontinued Update Emerging treatments for acute and chronic pain Development Status, Route, Contact information Status Agent Description / Mechanism of Opioid Function / Target Indication / Other Comments Sponsor / Originator Status Route URL Action (Y/No) 2019 UPDATES / CONTINUING PRODUCTS FROM 2018 Small molecule, inhibition of 1% diacerein TWi Biotechnology / caspase-1, block activation of 1 (AC-203 / caspase-1 inhibitor Inherited Epidermolysis Bullosa Castle Creek Phase 2 No Topical www.twibiotech.com NLRP3 inflamasomes; reduced CCP-020) Pharmaceuticals IL-1beta and IL-18 Small molecule; topical NSAID Frontier 2 AB001 NSAID formulation (nondisclosed active Chronic low back pain Phase 2 No Topical www.frontierbiotech.com/en/products/1.html Biotechnologies ingredient) Small molecule; oral uricosuric / anti-inflammatory agent + febuxostat (xanthine oxidase Gout in patients taking urate- Uricosuric + 3 AC-201 CR inhibitor); inhibition of NLRP3 lowering therapy; Gout; TWi Biotechnology Phase 2 No Oral www.twibiotech.com/rAndD_11 xanthine oxidase inflammasome assembly, reduced Epidermolysis Bullosa Simplex (EBS) production of caspase-1 and cytokine IL-1Beta www.arraybiopharma.com/our-science/our-pipeline AK-1830 Small molecule; tropomyosin Array BioPharma / 4 TrkA Pain, inflammation Phase 1 No Oral www.asahi- A (ARRY-954) receptor kinase A (TrkA) inhibitor Asahi Kasei Pharma kasei.co.jp/asahi/en/news/2016/e160401_2.html www.neurosmedical.com/clinical-research;
    [Show full text]
  • Classification Decisions Taken by the Harmonized System Committee from the 47Th to 60Th Sessions (2011
    CLASSIFICATION DECISIONS TAKEN BY THE HARMONIZED SYSTEM COMMITTEE FROM THE 47TH TO 60TH SESSIONS (2011 - 2018) WORLD CUSTOMS ORGANIZATION Rue du Marché 30 B-1210 Brussels Belgium November 2011 Copyright © 2011 World Customs Organization. All rights reserved. Requests and inquiries concerning translation, reproduction and adaptation rights should be addressed to [email protected]. D/2011/0448/25 The following list contains the classification decisions (other than those subject to a reservation) taken by the Harmonized System Committee ( 47th Session – March 2011) on specific products, together with their related Harmonized System code numbers and, in certain cases, the classification rationale. Advice Parties seeking to import or export merchandise covered by a decision are advised to verify the implementation of the decision by the importing or exporting country, as the case may be. HS codes Classification No Product description Classification considered rationale 1. Preparation, in the form of a powder, consisting of 92 % sugar, 6 % 2106.90 GRIs 1 and 6 black currant powder, anticaking agent, citric acid and black currant flavouring, put up for retail sale in 32-gram sachets, intended to be consumed as a beverage after mixing with hot water. 2. Vanutide cridificar (INN List 100). 3002.20 3. Certain INN products. Chapters 28, 29 (See “INN List 101” at the end of this publication.) and 30 4. Certain INN products. Chapters 13, 29 (See “INN List 102” at the end of this publication.) and 30 5. Certain INN products. Chapters 28, 29, (See “INN List 103” at the end of this publication.) 30, 35 and 39 6. Re-classification of INN products.
    [Show full text]
  • Perspektive 2023
    Perspektive 2023 Neue Medikamente in Entwicklung Inhalt 2 Neue Medikamente in Sicht 6 Neue Wege 8 Neue Chancen für Krebspatienten 10 Entzündungen zum Erliegen bringen 13 Infektionen bekämpfen 14 Gegen Krankheiten unterschiedlichster Art 16 Kindermedikamente und Orphan Drugs 19 Medikamente für Männer und Frauen 20 Die neuen Wirkstoffe 23 Der Beitrag Deutschlands 26 Projekte, die bis 2023 zu einer Zulassung führen können 44 Schwerpunkte der vfa-Mitglieder 46 Kontakt Blick voraus Mehr als zehn Jahre dauert es von der Idee bis zur Zulassung, manch- mal mehr als zwanzig. Erfolge mit neuen Medikamenten kann also nur ernten, wer lange vorher gesät hat. Das haben die forschenden Pharma-Unternehmen des vfa in den späten 2000er- und frühen 2010er-Jahren reichlich getan, so dass nun besonders viele Medika- mente in ihrer Erprobung weit fort geschritten sind. Welche es noch vor Ende 2023 bis zu einer Zulassung oder Zulassungserweiterung schaffen könnten, zeigt diese Veröffentlichung. Sie macht deutlich, dass zahlreiche Patientinnen und Patienten gute Aussichten auf bessere Behandlungsmöglich keiten für ihre Leiden haben. vfa – die forschenden Pharma-Unternehmen Perspektive 2023 Neue Medikamente in Sicht Viele Krankheiten sind in den letzten Jahren besser behandelbar geworden, und Patienten und Ärzte hoffen, dass dieser Strom des Fortschritts nicht abreißt. Die Chancen dafür stehen gut. Denn forschende Pharma-Unternehmen entwickeln derzeit gegen mehr als 145 Krankheiten Medikamente, die bis spätestens Ende 2023 die Zulassung erhalten könnten. Das zeigt eine Erhebung des vfa bei seinen Mitgliedsunter nehmen vom Oktober 2019. Demnach könnten bis Ende 2023 insgesamt 434 Sämtliche Projekte, die in der Erhebung erfasst ihrer Projekte zu einer Zulassung oder Zulassungs- wurden, sind ab S.
    [Show full text]
  • DMM Model of Osteoarthritis
    WHY DOES MY JOINT HURT: UNDERSTANDING DISEASE PHENOTYPE AND PAIN RELATIONSHIPS USING MOUSE MODELS OF ARTHRITIS Sanaa Zaki A thesis submitted in fulfilment of requirements for the degree of Doctor of Philosophy Faculty of Medicine (Sydney Medical School) The University of Sydney November 2016 i PREFACE The research embodied in this thesis was conducted at the Raymond Purves Laboratories of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney at the Royal North Shore Hospital, St Leonards, Australia. Institutional ethics committee approval was sought and obtained prior to the commencement of all animal experiments. The research was partly funded by Arthritis Australia. I certify that the intellectual content of this thesis is the product of my own work, including the design, conduct and analysis of experiments presented in this thesis. Contributions of other researchers and all the assistance received in preparing this thesis and relevant sources have been acknowledged. This thesis has not been submitted for any degree or other purpose. Sanaa Zaki ii ACKNOWLEDGEMENTS My PhD candidature has been a very long journey and I have many colleagues, friends and family that I need to acknowledge for their contribution. Firstly, I am forever indebted to the support and mentorship of my two supervisors, Mark Connor and Chris Little. They graciously bestowed me with the freedom to pave my own path of scientific discovery, while always being there to guide and redirect me when I needed it the most. I am truly indebted to their academic brilliance, scientific rigor and boundless patience. They are truly inspirational researchers that I can only hope to, one day, emulate.
    [Show full text]
  • This Year 2017 in Aperplexing World
    sph this year 2017 in a perplexing world. in aperplexing THOUGHT “ Our core purpose commits us to redouble our eort to ensure that we narrow these divides to produce the science and scholarship that contributes to a better, healthier world for all.” DEAR COLLEAGUES: WELCOME TO SPH THIS YEAR, our School’s us to always ask what the role of public health is in annual report. these changing times. To that end, while in this issue Our School’s core purpose is “Think. Teach. Do. of SPH This Year we feature the work of the School, For the health of all.” This aims to describe and we also feature 23 deans and program directors of animate what we do: we generate ideas through our other schools and programs talking about the role scholarship and research, think; we transmit this of public health in these times—their comments knowledge to the next generation, teach; and we work are captured on pages 46 to 49 of this issue and on to communicate these ideas and be a part of the the web at bu.edu/sph/thisyear17—who create a action that contributes to a healthier world, do. This compelling portrait of the central role that academic issue of SPH This Year focuses on our scholarship at public health stands to play in the years ahead. Thank a time when thought and science have become more you to all of our colleagues who participated in these important than ever. interviews; we learned from all your comments and Over the past year, we have seen the country— are excited to work together in the coming years.
    [Show full text]
  • A Patient's Guide to Living with Osteoarthritis
    Raising the Voice of Patients A PATIENT’S GUIDE TO LIVING WITH OSTEOARTHRITIS First Edition ©2017 GLOBAL HEALTHY LIVING FOUNDATION, INC. Welcome to the first edition of CreakyJoints’ patient guidelines for osteoarthritis (OA). It is designed to help raise your voice with the decision-makers you’ll encounter while living with this condition. This guide is the first of its kind, and it is developed by leading experts including doctors, patients, and other healthcare providers. It’s meant to serve as a roadmap to help you navigate your OA, while helping you get what you want, need and deserve from your treatment journey. It offers detailed, accessible explanations of symptoms and what causes them, treatment plans, treatment options, integrated medicines and therapies, diet and exercise, as well as how to talk to your insurance company, and your family and friends about your disease and the ways in which it impacts your life. This first edition has been edited by leading doctors and healthcare experts, and will be updated and improved regularly as new research, information, and treatments on OA become available. p The information in these guidelines should never replace the information and advice from your treating physician. It is meant to inform the discussion that you have with healthcare professionals, as well as others who play a role in your care and well-being. Table of Contents 2 PART ONE Patient Charter 4 PART TWO Introduction 6 PART THREE Treatment Guidelines 9 PART FOUR Osteoarthritis Overview 11 PART FIVE Monitoring 14 PART SIX
    [Show full text]
  • TRPA1 As a Novel Factor and Drug Target in Osteoarthritis
    ELINA NUMMENMAA TRPA1 as a Novel Factor and Drug Target in Osteoarthritis Tampere University Dissertations 210 Tampere University Dissertations 210 ELINA NUMMENMAA TRPA1 as a Novel Factor and Drug Target in Osteoarthritis ACADEMIC DISSERTATION To be presented, with the permission of the Faculty of Medicine and Health Technology of Tampere University, for public discussion in the auditorium F115 of the Arvo building, Arvo Ylpön katu 34, Tampere, on 7 February 2020, at 12 o’clock. ACADEMIC DISSERTATION The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University Tampere University Hospital Coxa Hospital for Joint Replacement Finland Responsible Professor Eeva Moilanen supervisor Tampere University and Custos Finland Supervisor Docent Katriina Vuolteenaho Tampere University Finland Pre-examiners Professor Jari Arokoski Ari-Pekka Koivisto, PhD University of Helsinki Stockholm University Finland Sweden Opponent Professor Ali Mobasheri State Research Institute Centre for Innovative Medicine Lithuania The originality of this thesis has been checked using the Turnitin OriginalityCheck service. Copyright ©2020 author Cover design: Roihu Inc. ISBN 978-952-03-1434-7 (print) ISBN 978-952-03-1435-4 (pdf) ISSN 2489-9860 (print) ISSN 2490-0028 (pdf) http://urn.fi/URN:ISBN:978-952-03-1435-4 PunaMusta Oy – Yliopistopaino Tampere 2020 CONTENTS LIST OF ORIGINAL COMMUNICATIONS ................................................................. 6 ABBREVIATIONS .........................................................................................................
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • De Videnskabsetiske Komiteers Fælles Årsberetning 2013 Appendiks
    De Videnskabsetiske Komiteers fælles årsberetning 2013 Appendiks Oversigt over anmeldte nye forskningsprojekter til komitésystemet i 2013 APPENDIKS FÆLLES ÅRSBERETNING 2013 INDHOLDSFORTEGNELSE Oversigt over projekter anmeldt til: Side Den Videnskabsetiske Komité for Region Nordjylland 3 ‐ 8 De Videnskabsetiske Komiteer for Region Midtjylland 9 ‐ 26 De Videnskabsetiske Komiteer for Region Syddanmark 27 ‐ 37 Den Videnskabsetiske Komité for Region Sjælland 38 ‐ 40 De Videnskabsetiske Komiteer for Region Hovedstaden 41 ‐ 80 Den Nationale Videnskabsetiske Komité 81 ‐ 84 2 APPENDIKS FÆLLES ÅRSBERETNING 2013 Projekter anmeldt til Den Videnskabsetiske Komité for Region Nordjylland Projekt‐ID Projekttitel N‐20130001 Neuropsykologisk undersøgelse med computerbaseret skærmtest før og efter ventilanlæggelse for idiopatisk Normaltrykshydrocephalus N‐20130002 Et randomiseret, dobbeltblindet, placebokontrolleret parallelgruppeforsøg om effekten og sikkerheden af pregabalin (to gange daglig) hos forsøgsdeltagere med posttraumatiske perifere neuropatiske smerter N‐20130003 MOMSAS – klinisk forskningsprojekt om anvendelse af lyd til analyse af gennemstrømning i blodkar til moderkagen N‐20130004 Facilitering af et kutant vasomotorisk respons ved lokal varmestimulering i et UVB‐ bestrålet område: Et mekanistisk studie med raske mennesker N‐20130005 Undersøgelse af topikalt L‐mentol og cinnamaldehyde som surrogatmodel for kulde‐ hypersensitivitet og sekundær hyperalgesi – simulering af neuropatiske symptomer N‐20130006 Udvikling af metode til individuel vurdering
    [Show full text]
  • Cartilage-Targeting Drug Delivery: Can Electrostatic Interactions Help?
    PERSPECTIVES and/or synovium. These techniques might OPINION be useful for delivering drugs for relieving pain and joint inflammation. However, Cartilage-targeting drug delivery: these approaches do not guarantee drug penetration into cartilage (or other target tissues) or reversible binding of drugs inside can electrostatic interactions help? cartilage. Both mechanisms are necessary to elicit the prolonged biological response Ambika G. Bajpayee and Alan J. Grodzinsky needed for cartilage protection. Abstract | Current intra-articular drug delivery methods do not guarantee Drug penetration and retention inside cartilage is a challenging problem. The sufficient drug penetration into cartilage tissue to reach cell and matrix targets at tissue’s ECM contains densely packed, highly the concentrations necessary to elicit the desired biological response. Here, we negatively charged aggrecan proteoglycans provide our perspective on the utilization of charge–charge (electrostatic) enmeshed within a complex collagen interactions to enhance drug penetration and transport into cartilage, and to network23; the ECM prevents sufficient enable sustained binding of drugs within the tissue’s highly negatively charged drug penetration, thereby enabling rapid clearance of the drug from the joint space24. extracellular matrix. By coupling drugs to positively charged nanocarriers that In this Perpsectives article, we first have optimal size and charge, cartilage can be converted from a drug barrier into describe candidate drugs for the treatment a drug reservoir
    [Show full text]
  • Novartis Floats 'Bold' Value-Based Reimbursement Idea in Migraine
    17 November 2017 No. 3880 Scripscrip.pharmaintelligence.informa.com Pharma intelligence | informa to file for approval of a CGRP therapy in the US and EU. Erenumab is on track for a po- tential first-in-class launch in 2018, with the proposed brand name Aimovig. Eli Lilly & Co. and Teva Pharmaceuti- cal Industries Ltd. are just behind with the CGRP inhibitors galcanezumab and freman- ezumab, respectively. (Also see “Lilly Breath- ing Down Amgen/Novartis’s Necks With Three Phase III Migraine Wins” Scrip, 12 May, 2017.) Teva has closed the gap, however, and may be the closest to beating Novartis and Amgen to the market. The company filed a biologic license application (BLA) with the FDA in October and used a priority review voucher to expedite the application’s review, which would position Teva’s freman- ezumab neck and neck in the US with Am- Shutterstock: Johan Swanepoel Shutterstock: gen/Novartis’ erenumab. Novartis believes the value case for a product like erenumab will be enhanced Novartis Floats ‘Bold’ Value-Based if the drug can be targeted to the patients that respond the best to treatment. Some migraine sufferers responded better to Reimbursement Idea In Migraine treatment in clinical trials than others, but JESSICA MERRILL [email protected] no biomarker has been identified to help target the drug to the right patients. ovartis AG has been one of the highlighting just how critical market access For example, among patients with epi- more proactive pharmaceutical and reimbursement has become to the spe- sodic migraines – those that experience Nmanufacturers when it comes to cialty drug segment.
    [Show full text]
  • Study on Osteoarthritis at Tertiary Care Centre and How to Diagnose
    International Journal of Science and Research (IJSR) ISSN: 2319-7064 ResearchGate Impact Factor (2018): 0.28 | SJIF (2018): 7.426 Study on Osteoarthritis at Tertiary Care Centre and How to Diagnose and to Differentiate Primary from Secondary Osteoarthritis and Methods of Managements and Prevention and Rationale of NSAIDs Prescriptions in Osteoarthritis Samikrishnan Perumal1, Senthakrishna Thangaraj2 1Senior Assistant Professor of Rheumatology, Government Mohan Kumaramangalam Medical College, Salem-30, Tamilnadu, India Email: drsamipk[at]gmail.com 2Medical Officer, Urban Health Centre, Salem Municipal Corporation, Salem, Tamilnadu, India Abstract: Aim: To evaluate the most useful and easily available diagnostic approaches on osteoarthritis. To identify quite beneficial modalities of non-pharmacologic management in osteoarthritis. To identify the suitable pharmacologic treatments of OA in above middle ages and in old ages. Objective of the Study: As everyone aware, osteoarthritis is a commonest disability prone disease. As against in the past, quite large number of cases are presenting with this disease, not just in old but from above Middle Ages. All over the globe, in both sexes, the life expectancy is being appreciably increased. Likewise, because of the rise in affluency and easy reach of opulent diets, most of them appears plumb and bellies and unfortunately, it’s all, often being seen in young and in middle ages. Thus, it ultimately leads to secondary flat foot and increase in intra-articular hypertension, medial and lateral tibiofemoral compartmental stress and repetitive injuries to internal structures of joints. When any one of these modifiable, non-modifiable and perpetual and repetitive causes are not removed, then, one must welcome, early onset of osteoarthritis.
    [Show full text]