Green Pit Viper Antivenom from Thailand and Agkistrodon Halys
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COTTONMOUTH Agkistrodon Piscivorus
COTTONMOUTH Agkistrodon piscivorus Agkistrodon is derived from ankistron and odon which in Greek mean “fishhook” and “tooth or teeth;” referring to the curved fangs of this species. Piscivorus is derived from piscis and voro which in Latin mean “fish” and “to eat”. Another common name for cottonmouth is water moccasin. The Cottonmouth is venomous. While its bite is rarely fatal, tissue damage is likely to occur and can be severe if not treated promptly. IDENTIFICATION Appearance: The cottonmouth is a stout- bodied venomous snake that reaches lengths of 30 to 42 inches as adults. Most adults are uniformly dark brown, olive, or black, tending to lose the cross banded patterning with age. Some individuals may have a dark cheek stripe (upper right image). The cottonmouth has the diagnostic features of the pit-viper family such as a wedge-shaped head, sensory pits between the eyes and nostrils, and vertical “cat-like” pupils. Juveniles are lighter and more boldly patterned with a yellow coloration toward the tip of the tail (lower right image). Dorsal scales are weakly keeled, and the subcaudal scales form only one row. Cottonmouths also have a single anal Mike Redmer plate. Subspecies: There are three subspecies of the cottonmouth. The Western Cottonmouth (A. p. leucostoma) is the only subspecies found in the Midwest. The term leucostoma refers to the white interior of mouth. Confusing Species: The non-venomous watersnakes (Nerodia) are commonly confused with Cottonmouths across their range, simply because they are snakes in water. Thus it is important to note that Cottonmouths are only found in southernmost Midwest. -
WHO Guidance on Management of Snakebites
GUIDELINES FOR THE MANAGEMENT OF SNAKEBITES 2nd Edition GUIDELINES FOR THE MANAGEMENT OF SNAKEBITES 2nd Edition 1. 2. 3. 4. ISBN 978-92-9022- © World Health Organization 2016 2nd Edition All rights reserved. Requests for publications, or for permission to reproduce or translate WHO publications, whether for sale or for noncommercial distribution, can be obtained from Publishing and Sales, World Health Organization, Regional Office for South-East Asia, Indraprastha Estate, Mahatma Gandhi Marg, New Delhi-110 002, India (fax: +91-11-23370197; e-mail: publications@ searo.who.int). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. -
Venomous Snakes of Texas.Pub
Price, Andrew. 1998. Poisonous Snakes of Texas. Texas Parks and Wildlife Department. Distributed by University of Texas Press, Austin, Texas. Tenant, Alan. 1998. A Field Guide to Texas Snakes. Gulf Publishing Com- pany, Houston, Texas. Texas Coral Snake, Micrurus fulvius Werler, John E. & James R. Dixon. tenere. This species averages 20 2000. Texas Snakes: Identification, inches (record 47 inches). Slender, Distribution, and Natural History. Uni- brightly colored snake with red, black versity of Texas Press, Austin, Texas. and yellow bands that completely en- circle the body. Red and yellow color touch. Venomous Snakes of East Texas Additional, more in depth information Written by: Gordon B. Henley, Jr. Zoo on snakes of Texas, in particular the Director venomous species, can be found in Photos by: Celia K. Falzone, General the following publications: Curator Editorial Assistance provided by: Conant, Roger & Joseph T. Collins. J. Colin Crawford, Education Assistant 1998. A Field Guide to Reptile and Amphibians: Eastern and Central North America. Houghton Mifflin Provided as a Public Service Company, Boston, Massachusetts. by Dixon, James R. 1987. Amphibians and Reptiles of Texas. Texas A&M University Press, College Station, Texas. (2nd Edition 2000). Venomous Snakes of East Texas with Emphasis on Angelina County Texas provides habitat for approximately 115 species of snakes with nearly 44 spe- cies found in the piney woods region of East Texas. Fifteen species of venomous snakes are found throughout the state while only 5 venomous species are found Southern Copperhead, Agkistrodon in the East Texas pine forests: two spe- contortrix contortrix. This species aver- cies of rattlesnakes; a copperhead; the ages 24 inches (record 52 inches). -
The Herpetological Journal
Volume 14, Number 1 January 2004 ISSN 0268-0130 THE HERPETOLOGICAL JOURNAL Published by the Indexed in BRITISH HERPETOLOGJCAL SOCIETY Current Contents HERPETOLOGICAL JOURNAL, Vol. 14, pp. 21-33 (2004) REASSESSMENT OF THE VALIDITY AND DIAGNOSIS OF THE PITVIPER TRIMERESUR US VE NUSTUS VOGEL, 1991 ANITA MALHOTRA AND ROGER S. THORPE School of Biological Sciences, University of Wa les Bangor, Bangor, UK Trimeresurus venustus Vogel, I 99 I was described from southern Thailand in I 991 ' and distinguished from the similar T. kanburiensis primarily by the following characters: 21 scale rows at midbody rather than I 9 and less irregular and indented supraoculars. However, very few specimens of T. kanburiensis were known at the time of this description, and the name T. venustus has not been universally accepted. Recently, live specimens from the type locality of T. kanburiensis in western Th ailand have become available, allowing a reassessment of the status -of the southern Thai population. Phylogenetic analysis of two mitochondrial gene regions indicated that specimens from south Thailand are genetically quite distinct from the specimen from the type locality, and the former are more closely related to T. macrops than to T. kanburiensis. We present a multivariate morphometric analysis of the six specimens of T. kanburiensis from the type locality that are now known and twenty specimens from southern Thai land. Despite the small sample size, it is clear that some of the diagnostic characteristics used to define T. venustus are invalid. We conclude that the current evidence indicates that T. venustus is a valid species, and present new diagnostic characters to separate it from T. -
(Gloydius Blomhoffii) Antivenom in Japan, Korea, and China
Jpn. J. Infect. Dis., 59, 20-24, 2006 Original Article Standardization of Regional Reference for Mamushi (Gloydius blomhoffii) Antivenom in Japan, Korea, and China Tadashi Fukuda*, Masaaki Iwaki, Seung Hwa Hong1, Ho Jung Oh1, Zhu Wei2, Kazunori Morokuma3, Kunio Ohkuma3, Lei Dianliang4, Yoshichika Arakawa and Motohide Takahashi Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208-0011; 3First, Production Department, Chemo-Sero-Therapeutic Research Institute, Kumamoto 860-8568, Japan; 1Korea Food and Drug Administration, Soul 122-704, Korea; 2Shanghai Institute of Biological Products, Shanghai 200052; and 4Department of Serum, National Institute for the Control of Pharmaceutical and Biological Products, Beijing 10050, People’s Republic of China (Received June 27, 2005. Accepted November 11, 2005) SUMMARY: The mamushi (Gloydius blomhoffii) snakes that inhabit Japan, Korea, and China produce venoms with similar serological characters to each other. Individual domestic standard mamushi antivenoms have been used for national quality control (potency testing) of mamushi antivenom products in these countries, because of the lack of an international standard material authorized by the World Health Organization. This precludes comparison of the results of product potency testing among countries. We established a regional reference antivenom for these three Asian countries. This collaborative study indicated that the regional reference mamushi antivenom has an anti-lethal titer of 33,000 U/vial and anti-hemorrhagic titer of 36,000 U/vial. This reference can be used routinely for quality control, including national control of mamushi antivenom products. reference antivenom. INTRODUCTION In the present study, the potency of a candidate regional Snakebites are a threat to human life in areas inhabited by reference mamushi antivenom produced by Shanghai Insti- poisonous snakes. -
Venomics of Trimeresurus (Popeia) Nebularis, the Cameron Highlands Pit Viper from Malaysia: Insights Into Venom Proteome, Toxicity and Neutralization of Antivenom
toxins Article Venomics of Trimeresurus (Popeia) nebularis, the Cameron Highlands Pit Viper from Malaysia: Insights into Venom Proteome, Toxicity and Neutralization of Antivenom Choo Hock Tan 1,*, Kae Yi Tan 2 , Tzu Shan Ng 2, Evan S.H. Quah 3 , Ahmad Khaldun Ismail 4 , Sumana Khomvilai 5, Visith Sitprija 5 and Nget Hong Tan 2 1 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; 2 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; [email protected] (K.Y.T.); [email protected] (T.S.N.); [email protected] (N.H.T.) 3 School of Biological Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia; [email protected] 4 Department of Emergency Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala Lumpur, Malaysia; [email protected] 5 Thai Red Cross Society, Queen Saovabha Memorial Institute, Bangkok 10330, Thailand; [email protected] (S.K.); [email protected] (V.S.) * Correspondence: [email protected] Received: 31 December 2018; Accepted: 30 January 2019; Published: 6 February 2019 Abstract: Trimeresurus nebularis is a montane pit viper that causes bites and envenomation to various communities in the central highland region of Malaysia, in particular Cameron’s Highlands. To unravel the venom composition of this species, the venom proteins were digested by trypsin and subjected to nano-liquid chromatography-tandem mass spectrometry (LC-MS/MS) for proteomic profiling. Snake venom metalloproteinases (SVMP) dominated the venom proteome by 48.42% of total venom proteins, with a characteristic distribution of P-III: P-II classes in a ratio of 2:1, while P-I class was undetected. -
Pit Vipers: from Fang to Needle—Three Critical Concepts for Clinicians
Tuesday, July 28, 2021 Pit Vipers: From Fang to Needle—Three Critical Concepts for Clinicians Keith J. Boesen, PharmD & Nicholas B. Hurst, M.D., MS Disclosures / Potential Conflicts of Interest • Keith Boesen and Nicholas Hurst are employed by Rare Disease Therapeutics, Inc. (RDT) • RDT is a U.S. company working with Laboratorios Silanes, S.A. de C.V., a company in Mexico • Laboratorios Silanes manufactures a variety of antivenoms Note: This program may contain the mention of suppliers, brands, products, services or drugs presented in a case study or comparative format using evidence-based research. Such examples are intended for educational and informational purposes and should not be perceived as an endorsement of any particular supplier, brand, product, service or drug. 2 Learning Objectives At the end of this session, participants should be able to: 1. Describe the venom variability in North American Pit Vipers 2. Evaluate the clinical symptoms associated with a North American Pit Viper envenomation 3. Develop a treatment plan for a North American Pit Viper envenomation 3 Audience Poll Question: #1 of 5 My level of expertise in treating Pit Viper Envenomation is… a. I wouldn’t know where to begin! b. I have seen a few cases… c. I know a thing or two because I’ve seen a thing or two d. I frequently treat these patients e. When it comes to Pit Viper envenomation, I am a Ssssuper Sssskilled Ssssnakebite Sssspecialist!!! 4 PIT VIPER ENVENOMATIONS PIT VIPERS Loreal Pits Movable Fangs 1. Russel 1983 -Photo provided by the Arizona Poison and Drug Information Center 1. -
Ecology, Behavior and Conservation of the Japanese Mamushi Snake, Gloydius Blomhoffii: Variation in Compromised and Uncompromised Populations
ECOLOGY, BEHAVIOR AND CONSERVATION OF THE JAPANESE MAMUSHI SNAKE, GLOYDIUS BLOMHOFFII: VARIATION IN COMPROMISED AND UNCOMPROMISED POPULATIONS By KIYOSHI SASAKI Bachelor of Arts/Science in Zoology Oklahoma State University Stillwater, OK 1999 Submitted to the Faculty of the Graduate College of the Oklahoma State University in partial fulfillment of the requirements for the Degree of DOCTOR OF PHILOSOPHY December, 2006 ECOLOGY, BEHAVIOR AND CONSERVATION OF THE JAPANESE MAMUSHI SNAKE, GLOYDIUS BLOMHOFFII: VARIATION IN COMPROMISED AND UNCOMPROMISED POPULATIONS Dissertation Approved: Stanley F. Fox Dissertation Adviser Anthony A. Echelle Michael W. Palmer Ronald A. Van Den Bussche A. Gordon Emslie Dean of the Graduate College ii ACKNOWLEDGMENTS I sincerely thank the following people for their significant contribution in my pursuit of a Ph.D. degree. I could never have completed this work without their help. Dr. David Duvall, my former mentor, helped in various ways until the very end of his career at Oklahoma State University. This study was originally developed as an undergraduate research project under Dr. Duvall. Subsequently, he accepted me as his graduate student and helped me expand the project to this Ph.D. research. He gave me much key advice and conceptual ideas for this study. His encouragement helped me to get through several difficult times in my pursuit of a Ph.D. degree. He also gave me several books as a gift and as an encouragement to complete the degree. Dr. Stanley Fox kindly accepted to serve as my major adviser after Dr. Duvall’s departure from Oklahoma State University and involved himself and contributed substantially to this work, including analysis and editing. -
Long-Term Effects of Snake Envenoming
toxins Review Long-Term Effects of Snake Envenoming Subodha Waiddyanatha 1,2, Anjana Silva 1,2 , Sisira Siribaddana 1 and Geoffrey K. Isbister 2,3,* 1 Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Saliyapura 50008, Sri Lanka; [email protected] (S.W.); [email protected] (A.S.); [email protected] (S.S.) 2 South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya 20400, Sri Lanka 3 Clinical Toxicology Research Group, University of Newcastle, Callaghan, NSW 2308, Australia * Correspondence: [email protected] or [email protected]; Tel.: +612-4921-1211 Received: 14 March 2019; Accepted: 29 March 2019; Published: 31 March 2019 Abstract: Long-term effects of envenoming compromise the quality of life of the survivors of snakebite. We searched MEDLINE (from 1946) and EMBASE (from 1947) until October 2018 for clinical literature on the long-term effects of snake envenoming using different combinations of search terms. We classified conditions that last or appear more than six weeks following envenoming as long term or delayed effects of envenoming. Of 257 records identified, 51 articles describe the long-term effects of snake envenoming and were reviewed. Disability due to amputations, deformities, contracture formation, and chronic ulceration, rarely with malignant change, have resulted from local necrosis due to bites mainly from African and Asian cobras, and Central and South American Pit-vipers. Progression of acute kidney injury into chronic renal failure in Russell’s viper bites has been reported in several studies from India and Sri Lanka. Neuromuscular toxicity does not appear to result in long-term effects. -
Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln US Army Research U.S. Department of Defense 2013 Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan Jason D. Heiner University of Washington - Seattle Campus, [email protected] Vikhyat S. Bebarta San Antonio Military Medical Center Shawn M. Varney San Antonio Military Medical Center Jason D. Bothwell Madigan Army Medical Center Aaron J. Cronin Womack Army Medical Center Follow this and additional works at: https://digitalcommons.unl.edu/usarmyresearch Heiner, Jason D.; Bebarta, Vikhyat S.; Varney, Shawn M.; Bothwell, Jason D.; and Cronin, Aaron J., "Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan" (2013). US Army Research. 198. https://digitalcommons.unl.edu/usarmyresearch/198 This Article is brought to you for free and open access by the U.S. Department of Defense at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in US Army Research by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. WILDERNESS & ENVIRONMENTAL MEDICINE, ], ]]]–]]] (2013) BRIEF REPORT Clinical Effects and Antivenom Use for Snake Bite Victims Treated at Three US Hospitals in Afghanistan Jason D. Heiner, MD; Vikhyat S. Bebarta, MD; Shawn M. Varney, MD; Jason D. Bothwell, MD; Aaron J. Cronin, PA-C From the University of Washington, Seattle, WA (Dr Heiner); the San Antonio Military Medical Center, Fort Sam Houston, TX (Drs Heiner, Bebarta, and Varney); the Madigan Army Medical Center, Joint Base Lewis-McCord, WA (Dr Bothwell); and the Womack Army Medical Center, Fort Bragg, NC (Mr Cronin). -
2019 Fry Trimeresurus Genus.Pdf
Toxicology Letters 316 (2019) 35–48 Contents lists available at ScienceDirect Toxicology Letters journal homepage: www.elsevier.com/locate/toxlet Clinical implications of differential antivenom efficacy in neutralising coagulotoxicity produced by venoms from species within the arboreal T viperid snake genus Trimeresurus ⁎ Jordan Debonoa, Mettine H.A. Bosb, Nathaniel Frankc, Bryan Frya, a Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD, 4072, Australia b Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands c Mtoxins, 1111 Washington Ave, Oshkosh, WI, 54901, USA ARTICLE INFO ABSTRACT Keywords: Snake envenomation globally is attributed to an ever-increasing human population encroaching into snake Venom territories. Responsible for many bites in Asia is the widespread genus Trimeresurus. While bites lead to hae- Coagulopathy morrhage, only a few species have had their venoms examined in detail. We found that Trimeresurus venom Fibrinogen causes haemorrhaging by cleaving fibrinogen in a pseudo-procoagulation manner to produce weak, unstable, Antivenom short-lived fibrin clots ultimately resulting in an overall anticoagulant effect due to fibrinogen depletion. The Phylogeny monovalent antivenom ‘Thai Red Cross Green Pit Viper antivenin’, varied in efficacy ranging from excellent neutralisation of T. albolabris venom through to T. gumprechti and T. mcgregori being poorly neutralised and T. hageni being unrecognised by the antivenom. While the results showing excellent neutralisation of some non-T. albolabris venoms (such as T. flavomaculaturs, T. fucatus, and T. macrops) needs to be confirmed with in vivo tests, conversely the antivenom failure T. -
Snakebite: the World's Biggest Hidden Health Crisis
Snakebite: The world's biggest hidden health crisis Snakebite is a potentially life-threatening neglected tropical disease (NTD) that is responsible for immense suffering among some 5.8 billion people who are at risk of encountering a venomous snake. The human cost of snakebite Snakebite Treatment Timeline Each year, approximately 5.4 million people are bitten by a snake, of whom 2.7 million are injected with venom. The first snake antivenom This leads to 400,000 people being permanently dis- produced, against the Indian Cobra. abled and between 83,000-138,000 deaths annually, Immunotherapy with animal- mostly in sub-Saharan Africa and South Asia. 1895 derived antivenom has continued to be the main treatment for snakebite evenoming for 120 years Snakebite: both a consequence and a cause of tropical poverty The Fav-Afrique antivenom, 2014 produced by Sanofi Pasteur (France) Survivors of untreated envenoming may be left with permanently discontinued amputation, blindness, mental health issues, and other forms of disability that severely affect their productivity. World Health Organization Most victims are agricultural workers and children in 2018 (WHO) lists snakebite envenoming the poorest parts of Africa and Asia. The economic as a neglected tropical disease cost of treating snakebite envenoming is unimaginable in most communities and puts families and communi- ties at risk of economic peril just to pay for treatment. WHO launches a strategy to prevent and control snakebite envenoming, including a program targeting affected communities and their health systems Global antivenom crisis 2019 The world produces less than half of the antivenom it The Scientific Research Partnership needs, and this only covers 57% of the world’s species for Neglected Tropical Snakbites of venomous snake.